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Paul Cairns

Research Profile

Genes & Molecular Sequences

Genes, Tumor Suppressor

Chemicals & Drugs

Physiology

Disorders

Procedures

Anatomy

Chromosomes, Human, Pair 9

Co-author Network

Publications

TOP 3
Hua Li; Marie E Maradeo; Michael Slifker; Peter J Tummino; Vinod Vathipadiekal; Michael J Birrer; Benjamin G Bitler; Paul Cairns; Caretha L Creasy; Rugang Zhang
ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.
Marie E Maradeo; Paul Cairns
Translational application of epigenetic alterations: ovarian cancer as a model.
Amanda M Hoffman; Paul Cairns
Epigenetics of kidney cancer and bladder cancer.

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All Publications

2012: Hua Li; Marie E Maradeo; Michael Slifker; Peter J Tummino; Vinod Vathipadiekal; Michael J Birrer; Benjamin G Bitler; Paul Cairns; Caretha L Creasy; Rugang Zhang
ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.
Cancer prevention research (Philadelphia, Pa.) 2012;5(3):484-91.
2011: Marie E Maradeo; Paul Cairns
Translational application of epigenetic alterations: ovarian cancer as a model.
FEBS letters 2011;585(13):2112-20.
2011: Amanda M Hoffman; Paul Cairns
Epigenetics of kidney cancer and bladder cancer.
Epigenomics 2011;3(1):19-34.
2011: Ilsiya Ibragimova; Paul Cairns
Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy.
Methods in molecular biology (Clifton, N.J.) 2011;780():277-91.
2010: Gowrishankar Banumathy; Paul Cairns
Signaling pathways in renal cell carcinoma.
Cancer biology & therapy 2010;10(7):658-64.
2010: Ilsiya Ibragimova; Inmaculada Ibáñez de Cáceres; Amanda M Hoffman; Anna Potapova; Essel Dulaimi; Tahseen Al-Saleem; Gary R Hudes; Michael Ochs; Paul Cairns
Global reactivation of epigenetically silenced genes in prostate cancer.
Cancer prevention research (Philadelphia, Pa.) 2010;3(9):1084-92.
2010: Paul Cairns
Renal cell carcinoma.
Cancer biomarkers : section A of Disease markers 2010;9(1-6):461-73.
2009: Paul Cairns
5'-azacytidine expression arrays.
Methods in molecular biology (Clifton, N.J.) 2009;507():165-74.
2008: Anna Potapova; Amanda M Hoffman; Andrew K Godwin; Tahseen Al-Saleem; Paul Cairns
Promoter hypermethylation of the PALB2 susceptibility gene in inherited and sporadic breast and ovarian cancer.
Cancer research 2008;68(4):998-1002.
2008: Jian Fu; Kathryn Fong; Alfonso Bellacosa; Eric Ross; Sinoula Apostolou; Daniel E Bassi; Fang Jin; Jirong Zhang; Paul Cairns; Inmaculada Ibañez de Caceres; Karl-Heinz Braunewell; Andres J P Klein-Szanto
VILIP-1 downregulation in non-small cell lung carcinomas: mechanisms and prediction of survival.
PloS one 2008;3(2):e1698.
2007: Paul Cairns
Gene methylation and early detection of genitourinary cancer: the road ahead.
Nature reviews. Cancer 2007;7(7):531-43.
2006: Inmaculada Ibanez de Caceres; Essel Dulaimi; Amanda M Hoffman; Tahseen Al-Saleem; Robert G Uzzo; Paul Cairns
Identification of novel target genes by an epigenetic reactivation screen of renal cancer.
Cancer research 2006;66(10):5021-8.
2004: Paul Cairns; Paul D Adams
Clipped wings: epigenetic inactivation of APC.
Cancer biology & therapy 2004;3(10):965-6.
2004: Essel Dulaimi; Jeanne Hillinck; Inmaculada Ibanez de Caceres; Tahseen Al-Saleem; Paul Cairns
Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(18 Pt 1):6189-93.
2004: Inmaculada Ibanez de Caceres; Cristina Battagli; Manel Esteller; James G Herman; Essel Dulaimi; Mitchell I Edelson; Cynthia Bergman; Hormoz Ehya; Burton L Eisenberg; Paul Cairns
Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients.
Cancer research 2004;64(18):6476-81.
2004: Tahseen Al-Saleem; Paul Cairns; Essel Dulaimi; Madelyn Feder; Joseph R Testa; Robert G Uzzo
The genetics of renal oncocytosis: a possible model for neoplastic progression.
Cancer genetics and cytogenetics 2004;152(1):23-8.
2004: Essel Dulaimi; Inmaculada Ibanez de Caceres; Robert G Uzzo; Tahseen Al-Saleem; Richard E Greenberg; Thomas J Polascik; James S Babb; William E Grizzle; Paul Cairns
Promoter hypermethylation profile of kidney cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(12 Pt 1):3972-9.
2004: Paul Cairns
Detection of promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients.
Annals of the New York Academy of Sciences 2004;1022():40-3.
2004: Essel Dulaimi; Robert G Uzzo; Richard E Greenberg; Tahseen Al-Saleem; Paul Cairns
Detection of bladder cancer in urine by a tumor suppressor gene hypermethylation panel.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(6):1887-93.
2004: Inmaculada Ibanez de Caceres; Natalya Frolova; Robert J Varkonyi; Essel Dulaimi; Neal J Meropol; Dominique Broccoli; Paul Cairns
Telomerase is frequently activated in tumors with microsatellite instability.
Cancer biology & therapy 2004;3(3):289-92.
2004: Rachel Krassenstein; Edward R Sauter; Essel Dulaimi; Cristina Battagli; Hormoz Ehya; Andres Klein-Szanto; Paul Cairns
Detection of breast cancer in nipple aspirate fluid by CpG island hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):28-32.
2003: Cristina Battagli; Robert G Uzzo; Essel Dulaimi; Inmaculada Ibanez de Caceres; Rachel Krassenstein; Tahseen Al-Saleem; Richard E Greenberg; Paul Cairns
Promoter hypermethylation of tumor suppressor genes in urine from kidney cancer patients.
Cancer research 2003;63(24):8695-9.
2003: Paul D Adams; Paul Cairns
Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells.
Cancer biology & therapy 2003;2(5):557-8.
2003: Robert G Uzzo; Paul Cairns; Tahseen Al-Saleem; Gary R Hudes; Naomi Haas; Richard E Greenberg; Vladimir Kolenko
The basic biology and immunobiology of renal cell carcinoma: considerations for the clinician.
The Urologic clinics of North America 2003;30(3):423-36.
2003: Amanda H Prowse; DC Schultz; S Guo; Lisa Vanderveer; J Dangel; Betsy Bove; Paul Cairns; Mary Daly; Andrew K Godwin
Identification of a splice acceptor site mutation in p16INK4A/p14ARF within a breast cancer, melanoma, neurofibroma prone kindred.
Journal of medical genetics 2003;40(8):e102.
2003: Mohammad Hoque; Chyi-Chia Richard Lee; Paul Cairns; Mark P Schoenberg; David Sidransky
Genome-wide genetic characterization of bladder cancer: a comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysis.
Cancer research 2003;63(9):2216-22.
2003: Abbas Abdollahi; Debra A Pisarcik; David Roberts; Jillian Weinstein; Paul Cairns; Thomas C Hamilton
LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer.
The Journal of biological chemistry 2003;278(8):6041-9.
2002: Thomas J Polascik; David G Bostwick; Paul Cairns
Molecular genetics and histopathologic features of adult distal nephron tumors.
Urology 2002;60(6):941-6.
2001: Paul Cairns; Manel Esteller; James G Herman; Mark P Schoenberg; Carmen Jeronimo; Montserrat Sanchez-Cespedes; N H Chow; M Grasso; LI WU; William H Westra; David Sidransky
Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(9):2727-30.
2000: K Yamaguchi; LI WU; Otavia L Caballero; Kenji Hibi; Barry Trink; Vicente A Resto; Paul Cairns; Kenji Okami; Wayne M Koch; David Sidransky; Jin Jen
Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2000;86(5):684-9.
2000: Montserrat Sanchez-Cespedes; Kenji Okami; Paul Cairns; David Sidransky
Molecular analysis of the candidate tumor suppressor gene ING1 in human head and neck tumors with 13q deletions.
Genes, chromosomes & cancer 2000;27(3):319-22.
1999: Kenji Okami; AL Reed; Paul Cairns; Wayne M Koch; William H Westra; Scott L Wehage; Jin Jen; David Sidransky
Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma.
Oncogene 1999;18(23):3541-5.
1998: Montserrat Sanchez-Cespedes; Paul Cairns; Jin Jen; David Sidransky
Degenerate oligonucleotide-primed PCR (DOP-PCR): evaluation of its reliability for screening of genetic alterations in neoplasia.
BioTechniques 1998;25(6):1036-8.
1998: N Halachmi; Sarel Halachmi; Ella Evron; Paul Cairns; Kenji Okami; Motoyasu Saji; William H Westra; Martha A Zeiger; Jin Jen; David Sidransky
Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.
Genes, chromosomes & cancer 1998;23(3):239-43.
1998: Paul Cairns; Ella Evron; Kenji Okami; N Halachmi; Manel Esteller; James G Herman; S Bose; SI Wang; Ramon Parsons; David Sidransky
Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers.
Oncogene 1998;16(24):3215-8.
1998: Barry Trink; Sara I Pai; S L Spunt; Venu Raman; Paul Cairns; Jin Jen; Edward Gabrielson; Saraswati Sukumar; David Sidransky
Absence of TSG101 transcript abnormalities in human cancers.
Oncogene 1998;16(21):2815-8.
1998: Kenji Okami; LI WU; Gregory J Riggins; Paul Cairns; Michael Goggins; Ella Evron; N Halachmi; Steven A Ahrendt; AL Reed; W Hilgers; Scott E Kern; Wayne M Koch; David Sidransky; Jin Jen
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.
Cancer research 1998;58(3):509-11.
1998: H Suzuki; Diha Freije; D R Nusskern; Kenji Okami; Paul Cairns; David Sidransky; William B Isaacs; G Steven Bova
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
Cancer research 1998;58(2):204-9.
1997: Kenji Okami; Paul Cairns; William H Westra; Jürgen F Linn; Steven A Ahrendt; LI WU; David Sidransky; Jin Jen
Detailed deletion mapping at chromosome 9p21 in non-small cell lung cancer by microsatellite analysis and fluorescence in situ hybridization.
International journal of cancer. Journal international du cancer 1997;74(6):588-92.
1997: Paul Cairns; Kenji Okami; P King; JT Bonacum; Steven A Ahrendt; LI WU; Li Mao; Jin Jen; David Sidransky
Genomic organization and mutation analysis of Hel-N1 in lung cancers with chromosome 9p21 deletions.
Cancer research 1997;57(23):5356-9.
1997: Paul Cairns; Kenji Okami; Sarel Halachmi; N Halachmi; Manel Esteller; James G Herman; Jin Jen; William B Isaacs; G Steven Bova; David Sidransky
Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.
Cancer research 1997;57(22):4997-5000.
1997: SI Wang; Janusz Puc; Jing Li; J N Bruce; Paul Cairns; David Sidransky; Ramon Parsons
Somatic mutations of PTEN in glioblastoma multiforme.
Cancer research 1997;57(19):4183-6.
1997: Ella Evron; Paul Cairns; N Halachmi; Steven A Ahrendt; AL Reed; David Sidransky
Normal polymorphism in the incomplete trinucleotide repeat of the arginine-rich protein gene.
Cancer research 1997;57(14):2888-9.
1997: David F Jarrard; G Steven Bova; Charles M Ewing; Sokhom Pin; SH Nguyen; Stephen B Baylin; Paul Cairns; David Sidransky; James G Herman; William B Isaacs
Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer.
Genes, chromosomes & cancer 1997;19(2):90-6.
1996: G Steiner; Paul Cairns; TJ Polascik; Fray F Marshall; Jonathan I Epstein; David Sidransky; Mark P Schoenberg
High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2.
Cancer research 1996;56(21):5044-6.
1996: AL Reed; Joseph A Califano; Paul Cairns; William H Westra; R M Jones; Wayne M Koch; Steven A Ahrendt; Yolanda Eby; Duane A Sewell; H Nawroz; J Bartek; David Sidransky
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.
Cancer research 1996;56(16):3630-3.
1996: Mieke Schutte; Ralph Hruban; L Hedrick; Kathleen R Cho; G M Nadasdy; C L Weinstein; G Steven Bova; William B Isaacs; Paul Cairns; H Nawroz; David Sidransky; Robert A Casero; P S Meltzer; Stephan Hahn; Scott E Kern
DPC4 gene in various tumor types.
Cancer research 1996;56(11):2527-30.
1996: TJ Polascik; Paul Cairns; Jonathan I Epstein; L Fuzesi; J Y Ro; Fray F Marshall; David Sidransky; Mark P Schoenberg
Distal nephron renal tumors: microsatellite allelotype.
Cancer research 1996;56(8):1892-5.
1996: H Fujii; C Marsh; Paul Cairns; David Sidransky; Edward Gabrielson
Genetic divergence in the clonal evolution of breast cancer.
Cancer research 1996;56(7):1493-7.
1995: TJ Polascik; Paul Cairns; W Y Chang; Mark P Schoenberg; David Sidransky
Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma.
Cancer research 1995;55(22):5396-9.
1995: M P Rosin; Paul Cairns; Jonathan I Epstein; Mark P Schoenberg; David Sidransky
Partial allelotype of carcinoma in situ of the human bladder.
Cancer research 1995;55(22):5213-6.
1995: Paul Cairns; TJ Polascik; Yolanda Eby; K Tokino; Joseph A Califano; A Merlo; Li Mao; J Herath; R Jenkins; William H Westra
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours.
Nature genetics 1995;11(2):210-2.
1995: W Y Chang; Paul Cairns; Mark P Schoenberg; TJ Polascik; David Sidransky
Novel suppressor loci on chromosome 14q in primary bladder cancer.
Cancer research 1995;55(15):3246-9.
1995: Paul Cairns; K Tokino; Yolanda Eby; David Sidransky
Localization of tumor suppressor loci on chromosome 9 in primary human renal cell carcinomas.
Cancer research 1995;55(2):224-7.
1995: Mark P Schoenberg; Paul Cairns; J D Brooks; Fray F Marshall; Jonathan I Epstein; William B Isaacs; David Sidransky
Frequent loss of chromosome arms 8p and 13q in collecting duct carcinoma (CDC) of the kidney.
Genes, chromosomes & cancer 1995;12(1):76-80.
1994: Paul Cairns; Li Mao; A Merlo; D J Lee; D Schwab; Yolanda Eby; K Tokino; P van der Riet; J E Blaugrund; David Sidransky
Rates of p16 (MTS1) mutations in primary tumors with 9p loss.
Science (New York, N.Y.) 1994;265(5170):415-7.
1994: Paul Cairns; K Tokino; Yolanda Eby; David Sidransky
Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction.
Cancer research 1994;54(6):1422-4.