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Richard Jove

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Chemicals & Drugs

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Sangkil Nam; Anne Schroeder; Wei Wen; Hua Yu; Yate-Ching Yuan; Xinlai Cheng; Gerhard Eisenbrand; Andreas Herrmann; Hongzhi Li; Karl-Heinz Merz; Richard Jove
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
Hong Xin; Chunyan Zhang; Wang Zhang; Jiehui Deng; Stephen Forman; Richard Jove; Heehyoung Lee; Yong Liu; Rongze Lu; Shudan Shen; Kay-Uwe Wagner; Hua Yu
G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells.
Liang Lu; Sangkil Nam; Wei Zhang; David A Horne; Richard Jove; Rich G Carter
Amphidinolide B: total synthesis, structural investigation, and biological evaluation.

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2013: Sangkil Nam; Anne Schroeder; Wei Wen; Hua Yu; Yate-Ching Yuan; Xinlai Cheng; Gerhard Eisenbrand; Andreas Herrmann; Hongzhi Li; Karl-Heinz Merz; Richard Jove
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
Molecular oncology 2013;7(3):369-78.
2013: Hong Xin; Chunyan Zhang; Wang Zhang; Jiehui Deng; Stephen Forman; Richard Jove; Heehyoung Lee; Yong Liu; Rongze Lu; Shudan Shen; Kay-Uwe Wagner; Hua Yu
G-protein-coupled Receptor Agonist BV8/Prokineticin-2 and STAT3 Protein Form a Feed-forward Loop in Both Normal and Malignant Myeloid Cells.
The Journal of biological chemistry 2013;288(19):13842-9.
2013: Liang Lu; Sangkil Nam; Wei Zhang; David A Horne; Richard Jove; Rich G Carter
Amphidinolide B: total synthesis, structural investigation, and biological evaluation.
The Journal of organic chemistry 2013;78(6):2213-47.
2013: John E DeLorbe; David Horne; Richard Jove; Steven M Mennen; Sangkil Nam; Fang-Li Zhang; Larry E Overman
General approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors: enantioselective total syntheses of (+)- and (-)-gliocladine C, (+)-leptosin D, (+)-T988C, (+)-bionectin A, and (+)-gliocladin A.
Journal of the American Chemical Society 2013;135(10):4117-28.
2013: Anna Scuto; Mark Kirschbaum; M Kujawski; Peter Atadja; R Buettner; J M Cermak; Richard Jove
SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells.
Cell death & disease 2013;4():e635.
2012: Sharad S Singhal; Jyotsana Singhal; Sanjay Awasthi; James Figarola; B Gabriel Gugiu; David Horne; Richard Jove; Kathryn Leake; Christopher Lincoln; Lokesh Prasad Gowda Dalasanur Nagaprashantha; Samuel Rahbar
1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma.
Biochemical pharmacology 2012;84(11):1419-27.
2012: Mardi de Veuve Alexis; Karl-Henrik Grinnemo; Richard Jove
The international translational regenerative medicine center.
Regenerative medicine 2012;7(6 Suppl):74-5.
2012: Lucy Liu; Prokopios Magiatis; Sangkil Nam; Leandros Skaltsounis; Yan Wang; Jun Wu; Fan Yang; Ralf Buettner; Nicolas Gaboriaud; Marina Kritsanida; Richard Jove
A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling.
Cancer biology & therapy 2012;13(13):1255-61.
2012: Sangkil Nam; Angela Perkins; Yan Wang; Jun Wu; Jun Xie; Rong-Zhen Xu; Fan Yang; David A Horne; Wendong Huang; Yuelong Ma; Richard Jove
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.
Molecular oncology 2012;6(5):484-93.
2012: Michael S Christodoulou; Nikolas Fokialakis; Richard Jove; Sangkil Nam; Alexios-Leandros Skaltsounis; Serkos A Haroutounian
Synthesis and in vitro biological evaluation of novel pyrazole derivatives as potential antitumor agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2012;8(5):779-88.
2012: Eirini Kouloura; Marie-Christine Lallemand; Marc Litaudon; Sangkil Nam; Khalijah Awang; Hamid A Hadi; Maria Halabalaki; Richard Jove; Alexios-Leandros Skaltsounis
Cytotoxic prenylated acetophenone dimers from Acronychia pedunculata.
Journal of natural products 2012;75(7):1270-6.
2012: Sangkil Nam; Sungman Park; Anna Scuto; Fan Yang; Hwa-Seung Yoo; Ravi Bhatia; Wenyong Chen; Xinlai Cheng; Gerhard Eisenbrand; Heiko Konig; Karl-Heinz Merz; Richard Jove
Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.
Molecular oncology 2012;6(3):276-83.
2012: Jiehui Deng; Robert A Figlin; Stephen Forman; Andreas Herrmann; Dave S B Hoon; Richard Jove; Maciej Kujawski; Heehyoung Lee; Jie Liu; Yong Liu; Sumanta K Pal; Saul J Priceman; Andrew Raubitschek; Shudan Shen; Chunyan Zhang; Wang Zhang; Hua Yu
S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites.
Cancer cell 2012;21(5):642-54.
2012: Heehyoung Lee; Arthur D Riggs; Zhenghe Wang; Hong Xin; Chunmei Yang; Stephen J Forman; Andreas Herrmann; Dave S B Hoon; Richard Jove; Peng Zhang; Hua Yu
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(20):7765-9.
2012: Fan Yang; Hua Yu; Tasnim Ara; Ralf Buettner; Yves A DeClerck; Veronica Jove; Sangkil Nam; Robert C Seeger; Yan Wang; Jun Wu; Hong Xin; Yibing Xu; Richard Jove
Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.
Cancer biology & therapy 2012;13(7):534-41.
2012: Fan Yang; Yun Yen; M L Richard Yip; Ralf Buettner; Shirley Chang; Michael Hedvat; Veronica Jove; Lucy Liu; Anna Scuto; Yan Tian; Timothy E van Meter; Wei Wen; Richard Jove
Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor.
Cancer biology & therapy 2012;13(6):349-57.
2012: Yan Tian; Fumiko Yakushijin; Kenichi Yakushijin; Fan Yang; Wei Liang; Lucy Liu; Yuelong Ma; Sangkil Nam; Ralf Buettner; David Horne; Richard Jove
Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells.
PloS one 2012;7(11):e49306.
2011: Hong Xin; Chunyan Zhang; Wang Zhang; Michael Zinda; Zhu A Cao; Robert Figlin; Michael Hedvat; Andreas Herrmann; Dennis Huszar; Richard Jove; Wei Liang; Deborah Morosini; Sumanta Pal; Karen Reckamp; Anna Scuto; Shaobu Weng; Hua Yu
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.
Cancer research 2011;71(21):6601-10.
2011: Wynn H Kao; Richard D Kennedy; Deepa S Kushwaha; Ralf Buettner; Clark C Chen; Alan D D'Andrea; Steven A Enkemann; Richard Jove; Kimberly Ng; Adam I Riker; Jorge L Sánchez; Néstor P Sánchez; Jaime L Villa; Pascal O Zinn; Jaime L Matta
Upregulation of Fanconi anemia DNA repair genes in melanoma compared with non-melanoma skin cancer.
The Journal of investigative dermatology 2011;131(10):2139-42.
2011: Yuelong Ma; Vinochani Pillay; Andrew J G Simpson; Piotr M Swiderski; Hua Yu; Otavia L Caballero; David A Horne; Richard Jove; Marcin Kortylewski; Claudia M Kowolik; Fook-Thean Lee; Andrew M Scott
Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.
ACS chemical biology 2011;6(9):962-70.
2011: Lucy Liu; Sangkil Nam; Yan Tian; Fan Yang; Jun Wu; Yan Wang; Anna Scuto; Panos Polychronopoulos; Prokopios Magiatis; Leandros Skaltsounis; Richard Jove
6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.
Cancer research 2011;71(11):3972-9.
2011: Leo Kretzner; Anna Scuto; Pamela M Dino; Claudia M Kowolik; Jun Wu; Patrick Ventura; Richard Jove; Stephen J Forman; Yun Yen; Mark Kirschbaum
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.
Cancer research 2011;71(11):3912-20.
2011: Ralf Buettner; Renzo Corzano; Rumana Rashid; Jianping Lin; Maheswari Senthil; Michael Hedvat; Anne Schroeder; Allen Mao; Andreas Herrmann; John Yim; Hongzhi Li; Yate-Ching Yuan; Kenichi Yakushijin; Fumiko Yakushijin; Nagarajan Vaidehi; Roger Moore; Gabriel Gugiu; Terry D Lee; Richard Yip; Yuan Chen; Richard Jove; David Horne; John C Williams
Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development.
ACS chemical biology 2011;6(5):432-43.
2011: Anna Scuto; Maciej Kujawski; Claudia M Kowolik; Ludmila Krymskaya; Lin Wang; Lawrence M Weiss; David Digiusto; Hua Yu; Stephen Forman; Richard Jove
STAT3 inhibition is a therapeutic strategy for ABC-like diffuse large B-cell lymphoma.
Cancer research 2011;71(9):3182-8.
2011: Anna Scuto; P Krejci; L Popplewell; J Wu; Y Wang; M Kujawski; Claudia M Kowolik; H Xin; Lieping Chen; Y Wang; L Kretzner; Hua Yu; W R Wilcox; Yun Yen; Stephen Forman; Richard Jove
The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.
Leukemia 2011;25(3):538-50.
2011: Rachel Haviland; Richard Jove; Yihong Ma; Susan Minton; Gregory Bloom; Steven Eschrich; W Douglas Cress
Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer.
PloS one 2011;6(10):e24923.
2010: Heehyoung Lee; Jiehui Deng; Maciej Kujawski; Chunmei Yang; Yong Liu; Andreas Herrmann; Marcin Kortylewski; David Horne; George Somlo; Stephen Forman; Richard Jove; Hua Yu
STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.
Nature medicine 2010;16(12):1421-8.
2010: Zhipeng Meng; Xianghui Fu; Xiaosong Chen; Samuel Zeng; Yan Tian; Richard Jove; Rongzhen Xu; Wendong Huang
miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice.
Hepatology (Baltimore, Md.) 2010;52(6):2148-57.
2010: Fan Yang; Christine Brown; Ralf Buettner; Michael Hedvat; Renate Starr; Anna Scuto; Anne Schroeder; Michael Jensen; Richard Jove
Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.
Molecular cancer therapeutics 2010;9(4):953-62.
2010: Jianming Lu; Keqiang Zhang; Sangkil Nam; Richard A Anderson; Richard Jove; Wei Wen
Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling.
Carcinogenesis 2010;31(3):481-8.
2010: Wei Liang; Maciej Kujawski; Jun Wu; Jianming Lu; Andreas Herrmann; Sofia Loera; Yun Yen; Frank Lee; Hua Yu; Wei Wen; Richard Jove
Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(3):924-35.
2010: Yuelong Ma; Sangkil Nam; Richard Jove; Kenichi Yakushijin; David A Horne
Synthesis and anticancer activities of ageladine A and structural analogs.
Bioorganic & medicinal chemistry letters 2010;20(1):83-6.
2009: Michael Hedvat; Dennis Huszar; Andreas Herrmann; Joseph M Gozgit; Anne Schroeder; Adam Sheehy; Ralf Buettner; David Proia; Claudia M Kowolik; Hong Xin; Brian Armstrong; Geraldine Bebernitz; Shaobu Weng; Lin Wang; Minwei Ye; Kristen McEachern; Huawei Chen; Deborah Morosini; Kirsten Bell; Marat Alimzhanov; Stephanos Ioannidis; Patricia McCoon; Zhu A Cao; Hua Yu; Richard Jove; Michael Zinda
The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.
Cancer cell 2009;16(6):487-97.
2009: Hua Yu; Drew M Pardoll; Richard Jove
STATs in cancer inflammation and immunity: a leading role for STAT3.
Nature reviews. Cancer 2009;9(11):798-809.
2009: Jianping Lin; Ralf Buettner; Yate-Ching Yuan; Richard Yip; David Horne; Richard Jove; Nagarajan Vaidehi
Molecular dynamics simulations of the conformational changes in signal transducers and activators of transcription, Stat1 and Stat3.
Journal of molecular graphics & modelling 2009;28(4):347-56.
2009: Marcin Kortylewski; Piotr Swiderski; Andreas Herrmann; Lin Wang; Claudia Kowolik; Maciej Kujawski; Heehyoung Lee; Anna Scuto; Yong Liu; Chunmei Yang; Jiehui Deng; Harris S Soifer; Andrew Raubitschek; Stephen Forman; John J Rossi; Drew M Pardoll; Richard Jove; Hua Yu
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.
Nature biotechnology 2009;27(10):925-32.
2009: Mulu Geletu; Chrystele Chaize; Rozanne Arulanandam; Adina Vultur; Claudia Kowolik; Aikaterini Anagnostopoulou; Richard Jove; Leda Raptis
Stat3 activity is required for gap junctional permeability in normal rat liver epithelial cells.
DNA and cell biology 2009;28(7):319-27.
2009: Jade Homsi; Christopher L Cubitt; Shumin Zhang; Pamela N Munster; Hua Yu; Daniel M Sullivan; Richard Jove; Jane L Messina; Adil I Daud
Src activation in melanoma and Src inhibitors as therapeutic agents in melanoma.
Melanoma research 2009;19(3):167-75.
2009: Heehyoung Lee; Andreas Herrmann; Jie-Hui Deng; Maciej Kujawski; Guilian Niu; Zhiwei Li; Steve Forman; Richard Jove; Drew M Pardoll; Hua Yu
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
Cancer cell 2009;15(4):283-93.
2009: Kenneth H Shain; Danielle N Yarde; Mark B Meads; Mei Huang; Richard Jove; Lori A Hazlehurst; William S Dalton
Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation.
Cancer research 2009;69(3):1009-15.
2008: Joelle Anne Hillion; Surajit Dhara; Takita Felder Sumter; Mita Mukherjee; Francescopaolo Di Cello; Amy Belton; James Turkson; Souyma Jaganathan; Linzhao Cheng; Zhaohui Ye; Richard Jove; Peter Aplan; Ying-Wei Lin; Kelsey Wertzler; Ray Reeves; Ossama Elbahlouh; Jeanne Kowalski; Raka Bhattacharya; Linda M. Resar
The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?
Cancer research 2008;68(24):10121-7.
2008: Heiko Konig; Mhairi Copland; Su Chu; Richard Jove; Tessa L Holyoake; Ravi Bhatia
Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells.
Cancer research 2008;68(23):9624-33.
2008: Ralf Buettner; Tania Mesa; Adina Vultur; Frank Lee; Richard Jove
Inhibition of Src family kinases with dasatinib blocks migration and invasion of human melanoma cells.
Molecular cancer research : MCR 2008;6(11):1766-74.
2008: Fan Yang; Timothy E van Meter; Ralf Buettner; Michael Hedvat; Wei Liang; Claudia M Kowolik; Nilesh Mepani; Janni Mirosevich; Sangkil Nam; Mike Y Chen; Gary Tye; Mark Kirschbaum; Richard Jove
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
Molecular cancer therapeutics 2008;7(11):3519-26.
2008: José Cangiano; Barbara A Centeno; Christopher R Garrett; William Cáceres; Ana de Jesús; Ji-Hyun Lee; Orestes Pavía; Richard Jove; Luis Báez; Daniel M Sullivan; Carlos A Muro-Cacho; Teresita Muñoz-Antonia
Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies.
Digestive diseases and sciences 2008;53(8):2090-100.
2008: Guilian Niu; Jon Briggs; Jiehui Deng; Yihong Ma; Heehyoung Lee; Marcin Kortylewski; Maciej Kujawski; Heidi Kay; W.Douglas Cress; Richard Jove; Hua Yu
Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.
Molecular cancer research : MCR 2008;6(7):1099-105.
2008: Jane L Messina; Hua Yu; Adam I Riker; Pamela N Munster; Richard Jove; Adil Daud
Activated stat-3 in melanoma.
Cancer control : journal of the Moffitt Cancer Center 2008;15(3):196-201.
2008: Yukiyasu Ozawa; Ann H Williams; Myka L Estes; Norimasa Matsushita; Frank Boschelli; Richard Jove; Alan F List
Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).
Leukemia research 2008;32(6):893-903.
2008: Anna Scuto; Mark Kirschbaum; Claudia Kowolik; Leo Kretzner; Agnes Juhasz; Peter Atadja; Vinod Pullarkat; Ravi Bhatia; Stephen Forman; Yun Yen; Richard Jove
The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
Blood 2008;111(10):5093-100.
2008: Adina Vultur; Ralf Buettner; Claudia Kowolik; Wei Liang; David Smith; Frank Boschelli; Richard Jove
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.
Molecular cancer therapeutics 2008;7(5):1185-94.
2007: Khandaker Siddiquee; Patrick T Gunning; Matthew Glenn; William P Katt; Shumin Zhang; Christopher Schrock; Christopher Schroeck; Said M Sebti; Richard Jove; Andrew D Hamilton; James Turkson
An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.
ACS chemical biology 2007;2(12):787-98.
2007: Anna Scuto; Hongling Zhang; Haiyan Zhao; Maria Rivera; Timothy J Yeatman; Richard Jove; Javier F Torres-Roca
RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase.
Cancer research 2007;67(21):10317-24.
2007: Ralf Buettner; Mei Huang; Tanya Gritsko; Jim Karras; Steven A Enkemann; Tania Mesa; Sangkil Nam; Hua Yu; Richard Jove
Activated signal transducers and activators of transcription 3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity.
Molecular cancer research : MCR 2007;5(8):823-32.
2007: Khandaker Siddiquee; Shumin Zhang; Wayne C Guida; Michelle A Blaskovich; Benjamin Greedy; Harshani R Lawrence; M L Richard Yip; Richard Jove; Mark M McLaughlin; Nicholas J Lawrence; Said M Sebti; James Turkson
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7391-6.
2007: Sangkil Nam; Ann Williams; Adina Vultur; Alan List; Kapil N Bhalla; David Smith; Francis Y Lee; Richard Jove
Dasatinib (BMS-354825) inhibits Stat5 signaling associated with apoptosis in chronic myelogenous leukemia cells.
Molecular cancer therapeutics 2007;6(4):1400-5.
2007: Patrick T Gunning; William P Katt; Matthew Glenn; Khandaker Siddiquee; Khandaker Siddique; Joon S Kim; Richard Jove; Said M Sebti; James Turkson; Andrew D Hamilton
Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains.
Bioorganic & medicinal chemistry letters 2007;17(7):1875-8.
2007: Audrey C Shor; Elizabeth A Keschman; Francis Y Lee; Carlos Muro-Cacho; G Douglas Letson; Jonathan Trent; Warren Pledger; Richard Jove
Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival.
Cancer research 2007;67(6):2800-8.
2007: Javier F Torres-Roca; Michelle DeSilvio; Linda B Mora; Li-Yan Khor; Elizabeth Hammond; Nazeel Ahmad; Richard Jove; Jeffrey D Forman; R Jeffrey Lee; Howard Sandler; Alan Pollack
Activated STAT3 as a correlate of distant metastasis in prostate cancer: a secondary analysis of Radiation Therapy Oncology Group 86-10.
Urology 2007;69(3):505-9.
2006: Aikaterini Anagnostopoulou; Adina Vultur; Rozanne Arulanandam; Jun Cao; James Turkson; Richard Jove; Joon S Kim; Matthew Glenn; Andrew D Hamilton; Leda Raptis
Differential effects of Stat3 inhibition in sparse vs confluent normal and breast cancer cells.
Cancer letters 2006;242(1):120-32.
2006: Janni Mirosevich; Nan Gao; Aparna Gupta; Scott B Shappell; Richard Jove; Robert J Matusik
Expression and role of Foxa proteins in prostate cancer.
The Prostate 2006;66(10):1013-28.
2006: Lanxi Song; Mark Morris; Tapan Bagui; Francis Y Lee; Richard Jove; Eric Haura
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival.
Cancer research 2006;66(11):5542-8.
2006: Anupama Kotha; Madhavi Sekharam; Lucia Cilenti; Khandaker Siddiquee; Annette Khaled; Antonis S Zervos; Bradford Carter; James Turkson; Richard Jove
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein.
Molecular cancer therapeutics 2006;5(3):621-9.
2006: Nills Diaz; Susan Minton; Charles Cox; Tammy Bowman; Tanya Gritsko; Roy Garcia; Ibrahim Eweis; Marek Wloch; Sandy Livingston; Ed Seijo; Alan Cantor; Ji-Hyun Lee; Craig Beam; Daniel Sullivan; Richard Jove; Carlos Muro-Cacho
Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):20-8.
2006: Tanya Gritsko; Ann Williams; James Turkson; Satoshi Kaneko; Tammy Bowman; Mei Huang; Sangkil Nam; Ibrahim Eweis; Nils Diaz; Daniel Sullivan; Sean Yoder; Steven A Enkemann; Steven Eschrich; Ji-Hyun Lee; Craig Beam; Jin Cheng; Susan Minton; Carlos Muro-Cacho; Richard Jove
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):11-9.
2006: Adam I Riker; Richard Jove; Adil Daud
Immunotherapy as part of a multidisciplinary approach to melanoma treatment.
Frontiers in bioscience : a journal and virtual library 2006;11():1-14.
2005: Marcin Kortylewski; Maciej Kujawski; Tianhong Wang; Sheng Wei; Shumin Zhang; Shari Pilon-Thomas; Guilian Niu; Heidi Kay; James J Mulé; William G Kerr; Richard Jove; Drew M Pardoll; Hua Yu
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Nature medicine 2005;11(12):1314-21.
2005: Sungman Park; Donghwa Kim; Satoshi Kaneko; Kristen M Szewczyk; Santo V Nicosia; Hua Yu; Richard Jove; Jin Q Cheng
Molecular cloning and characterization of the human AKT1 promoter uncovers its up-regulation by the Src/Stat3 pathway.
The Journal of biological chemistry 2005;280(47):38932-41.
2005: Sangkil Nam; Donghwa Kim; Jin Q Cheng; Shumin Zhang; Ji-Hyun Lee; Ralf Buettner; Janni Mirosevich; Francis Y Lee; Richard Jove
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.
Cancer research 2005;65(20):9185-9.
2005: James Turkson; Shumin Zhang; Linda B Mora; Audrey Burns; Said Sebti; Richard Jove
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells.
The Journal of biological chemistry 2005;280(38):32979-88.
2005: Guilian Niu; Kenneth L Wright; Yihong Ma; Gabriela M Wright; Mei Huang; Rosalyn B Irby; Jon Briggs; James Karras; W.Douglas Cress; Drew M Pardoll; Richard Jove; Jiangdong Chen; Hua Yu
Role of Stat3 in regulating p53 expression and function.
Molecular and cellular biology 2005;25(17):7432-40.
2005: Qing Xu; Jon Briggs; Sungman Park; Guilian Niu; Marcin Kortylewski; Shumin Zhang; Tanya Gritsko; James Turkson; Heidi Kay; Gregg L Semenza; Jin Q Cheng; Richard Jove; Hua Yu
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways.
Oncogene 2005;24(36):5552-60.
2005: Javier F Torres-Roca; Steven Eschrich; Haiyan Zhao; Gregory C Bloom; Jimmy Sung; Susan McCarthy; Alan B Cantor; Anna Scuto; Changgong Li; Suming Zhang; Richard Jove; Timothy J Yeatman
Prediction of radiation sensitivity using a gene expression classifier.
Cancer research 2005;65(16):7169-76.
2005: Adina Vultur; Rozanne Arulanandam; James Turkson; Guilian Niu; Richard Jove; Leda Raptis
Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen.
Molecular biology of the cell 2005;16(8):3832-46.
2005: Eric Haura; James Turkson; Richard Jove
Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer.
Nature clinical practice. Oncology 2005;2(6):315-24.
2005: Marcin Kortylewski; Richard Jove; Hua Yu
Targeting STAT3 affects melanoma on multiple fronts.
Cancer metastasis reviews 2005;24(2):315-27.
2005: Daniel J Dauer; Bernadette Ferraro; Lanxi Song; Bin Yu; Linda B Mora; Ralf Buettner; Steven A Enkemann; Richard Jove; Eric Haura
Stat3 regulates genes common to both wound healing and cancer.
Oncogene 2005;24(21):3397-408.
2005: Jiazhi Sun; Michelle A Blaskovich; Richard Jove; Sandra K Livingston; Domenico Coppola; Said M Sebti
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity.
Oncogene 2005;24(20):3236-45.
2005: Sangkil Nam; Ralf Buettner; James Turkson; Donghwa Kim; Jin Q Cheng; Stephan Muehlbeyer; Frankie Hippe; Sandra Vatter; Karl-Heinz Merz; Gerhard Eisenbrand; Richard Jove
Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):5998-6003.
2005: Mohamed Rahmani; Erin Reese; Yun Dai; Cheryl Bauer; Lora B Kramer; Mei Huang; Richard Jove; Paul Dent; Steven Grant
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Molecular pharmacology 2005;67(4):1166-76.
2004: James Turkson; Shumin Zhang; Jay Palmer; Heidi Kay; Joseph Stanko; Linda B Mora; Said Sebti; Hua Yu; Richard Jove
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity.
Molecular cancer therapeutics 2004;3(12):1533-42.
2004: Joel G Turner; Roxanne Engel; Jennifer A Derderian; Richard Jove; Daniel M Sullivan
Human topoisomerase IIalpha nuclear export is mediated by two CRM-1-dependent nuclear export signals.
Journal of cell science 2004;117(Pt 14):3061-71.
2004: Adina Vultur; Jun Cao; Rozanne Arulanandam; James Turkson; Richard Jove; Peter Greer; Andrew Craig; Bruce Elliott; Leda Raptis
Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.
Oncogene 2004;23(15):2600-16.
2004: James Turkson; Joon S Kim; Shumin Zhang; Jing Yuan; Mei Huang; Matthew Glenn; Eric Haura; Said Sebti; Andrew D Hamilton; Richard Jove
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity.
Molecular cancer therapeutics 2004;3(3):261-9.
2004: Yuan Ren; Songshu Meng; Lin Mei; Zhizhuang Joe Zhao; Richard Jove; Jie Wu
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
The Journal of biological chemistry 2004;279(9):8497-505.
2004: Jason Savell; Yihong Ma; Kristin S Morrow; Richard Jove; Nancy Olashaw; Pope L Moseley; W.Douglas Cress; Walker Wharton
AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1.
Molecular cancer therapeutics 2004;3(2):205-13.
2004: Hua Yu; Richard Jove
The STATs of cancer--new molecular targets come of age.
Nature reviews. Cancer 2004;4(2):97-105.
2004: Tianhong Wang; Guilian Niu; Marcin Kortylewski; Lyudmila Burdelya; Kenneth Shain; Shumin Zhang; Raka Bhattacharya; Dmitry I Gabrilovich; Richard Heller; Domenico Coppola; William Dalton; Richard Jove; Drew M Pardoll; Hua Yu
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Nature medicine 2004;10(1):48-54.
2004: Yulia Nefedova; Mei Huang; Sergei Kusmartsev; Raka Bhattacharya; Pingyan Cheng; Raoul Salup; Richard Jove; Dmitry I Gabrilovich
Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):464-74.
2003: Subhra Mohapatra; Baoky Chu; Sheng Wei; Julie Y Djeu; Pearlie K Epling-Burnette; Thomas P Loughran; Richard Jove; Warren Pledger
Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2.
Cancer research 2003;63(23):8523-30.
2003: Mei Sun; Lin Yang; Richard I Feldman; Xiameng SUN; Kapil N Bhalla; Richard Jove; Santo V Nicosia; Jin Q Cheng
Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src.
The Journal of biological chemistry 2003;278(44):42992-3000.
2003: Shohreh Iravani; Hong Q Zhang; Zeng Q Yuan; Jin Q Cheng; Richard C Karl; Richard Jove; Domenico Coppola
Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia.
Human pathology 2003;34(10):975-82.
2003: Fengdong Cheng; Hong-Wei Wang; Alex Cuenca; Mei Huang; Tomar Ghansah; Jason Brayer; William G Kerr; Kiyoshi Takeda; Shizuo Akira; Stephen P Schoenberger; Hua Yu; Richard Jove; Eduardo M Sotomayor
A critical role for Stat3 signaling in immune tolerance.
Immunity 2003;19(3):425-36.
2003: Ramadevi Nimmanapalli; Lianne Fuino; Purva Bali; Maura Gasparetto; Michele Glozak; Jianguo Tao; Lynn Moscinski; Clayton Smith; Jie Wu; Richard Jove; Peter Atadja; Kapil N Bhalla
Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells.
Cancer research 2003;63(16):5126-35.
2003: Lanxi Song; James Turkson; James Karras; Richard Jove; Eric Haura
Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells.
Oncogene 2003;22(27):4150-65.
2003: Leda Raptis; Valerie Balboa; Tina Hsu; Adina Vultur; James Turkson; Richard Jove; Kevin L Firth
In situ electroporation of large numbers of cells using minimal volumes of material.
Analytical biochemistry 2003;317(1):124-8.
2003: Yihong Ma; Jing Yuan; Mei Huang; Richard Jove; W.Douglas Cress
Regulation of the cyclin D3 promoter by E2F1.
The Journal of biological chemistry 2003;278(19):16770-6.
2003: Michelle A Blaskovich; Jiazhi Sun; Alan Cantor; James Turkson; Richard Jove; Said M Sebti
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
Cancer research 2003;63(6):1270-9.
2003: Christopher Y Thomas; Michael Chouinard; Michael Cox; Sarah Parsons; Melody Stallings-Mann; Roy Garcia; Richard Jove; Robert Wharen
Spontaneous activation and signaling by overexpressed epidermal growth factor receptors in glioblastoma cells.
International journal of cancer. Journal international du cancer 2003;104(1):19-27.
2003: Sylvie Wittmann; Purva Bali; Sreenivasa Donapaty; Ramadevi Nimmanapalli; Fei Guo; Hirohito Yamaguchi; Mei Huang; Richard Jove; Hong-Gang Wang; Kapil N Bhalla
Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Cancer research 2003;63(1):93-9.
2002: Mei Huang; Jay F Dorsey; Pearlie K Epling-Burnette; Ramadevi Nimmanapalli; Terry Landowski; Linda B Mora; Guilian Niu; Dominic Sinibaldi; Fanqi Bai; Alan J Kraker; Hua Yu; Lynn Moscinski; Sheng Wei; Julie Y Djeu; William S Dalton; Kapil N Bhalla; Thomas P Loughran; Jie Wu; Richard Jove
Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells.
Oncogene 2002;21(57):8804-16.
2002: Linda B Mora; Ralf Buettner; John Seigne; Jose Diaz; Nazeel Ahmad; Roy Garcia; Tammy Bowman; Robert Falcone; Rita Fairclough; Alan Cantor; Carlos Muro-Cacho; Sandy Livingston; James Karras; Julio Pow-Sang; Richard Jove
Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.
Cancer research 2002;62(22):6659-66.
2002: Renae L Malek; Rosalyn B Irby; Qingbin M Guo; Kerry Lee; Sylvia Wong; Mei He; Jennifer Tsai; Bryan Frank; Edison Liu; John Quackenbush; Richard Jove; Timothy J Yeatman; Norman H Lee
Identification of Src transformation fingerprint in human colon cancer.
Oncogene 2002;21(47):7256-65.
2002: Ramadevi Nimmanapalli; Erica O'Bryan; Mei Huang; Purva Bali; Pearlie Kay Burnette; Thomas P Loughran; James Tepperberg; Richard Jove; Kapil N Bhalla
Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin.
Cancer research 2002;62(20):5761-9.
2002: Guilian Niu; Tammy Bowman; Mei Huang; Steve Shivers; Douglas Reintgen; Adil Daud; Alfred E Chang; Alan J Kraker; Richard Jove; Hua Yu
Roles of activated Src and Stat3 signaling in melanoma tumor cell growth.
Oncogene 2002;21(46):7001-10.
2002: Andrea Bild; Francisco J Mendoza; Erika M Gibson; Mei Huang; Jacylyn Villanueva; Timothy P Garrington; Richard Jove; Gary L Johnson; Spencer B Gibson
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage.
Oncogene 2002;21(43):6649-56.
2002: Sharlene Velichko; T Charis Wagner; James Turkson; Richard Jove; Ed Croze
STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues.
The Journal of biological chemistry 2002;277(38):35635-41.
2002: Lyudmila Burdelya; Robyn Catlett-Falcone; Alexander Levitzki; Fengdong Cheng; Linda B Mora; Eduardo M Sotomayor; Domenico Coppola; JiaZhi Sun; Said Sebti; William S Dalton; Richard Jove; Hua Yu
Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.
Molecular cancer therapeutics 2002;1(11):893-9.
2002: Jay F Dorsey; Jess M Cunnick; R Lanehart; M Huang; Alan J Kraker; Kapil N Bhalla; Richard Jove; Jie Wu
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors.
Leukemia 2002;16(9):1589-95.
2002: Andrea Bild; James Turkson; Richard Jove
Cytoplasmic transport of Stat3 by receptor-mediated endocytosis.
The EMBO journal 2002;21(13):3255-63.
2002: Pearlie K Epling-Burnette; Roy Garcia; Fanqi Bai; Sajid Ismail; Thomas P Loughran; Julie Y Djeu; Richard Jove; Sheng Wei
Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils.
Cellular immunology 2002;217(1-2):1-11.
2002: Ralf Buettner; Linda B Mora; Richard Jove
Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):945-54.
2002: Guilian Niu; Kenneth L Wright; Mei Huang; Lanxi Song; Eric Haura; James Turkson; Shumin Zhang; Tianhong Wang; Dominic Sinibaldi; Domenico Coppola; Richard Heller; Lee M Ellis; James Karras; Jacqueline F Bromberg; Drew M Pardoll; Richard Jove; Hua Yu
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.
Oncogene 2002;21(13):2000-8.
2002: Emmanuel N Lazaridis; Dominic Sinibaldi; Gregory C Bloom; Shrikant M Mane; Richard Jove
A simple method to improve probe set estimates from oligonucleotide arrays.
Mathematical biosciences 2002;176(1):53-8.
2002: Yu-Wen Zhang; Ling-Mei Wang; Richard Jove; George Vande Woude
Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis.
Oncogene 2002;21(2):217-26.
2001: MM Oshiro; Terry Landowski; Robyn Catlett-Falcone; Lori A Hazlehurst; M Huang; Richard Jove; William S Dalton
Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):4262-71.
2001: James Turkson; D Ryan; Joon S Kim; Y Zhang; Z Chen; Eric Haura; A Laudano; Said Sebti; Andrew D Hamilton; Richard Jove
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.
The Journal of biological chemistry 2001;276(48):45443-55.
2001: Linda B Mora; R Buettner; Nazeel Ahmad; Y Bassel; Richard Jove; John Seigne
Prostate adenocarcinoma: cellular and molecular abnormalities.
Cancer control : journal of the Moffitt Cancer Center 2001;8(6):551-61.
2001: M Sun; G Wang; June E Paciga; Richard I Feldman; Zeng-qiang Yuan; X L Ma; Sue A Shelley; Richard Jove; Philip Tsichlis; Santo V Nicosia; Jin Q Cheng
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells.
The American journal of pathology 2001;159(2):431-7.
2001: Tammy Bowman; Martin A Broome; Dominic Sinibaldi; Walker Wharton; Warren Pledger; J M Sedivy; R Irby; T Yeatman; SA Courtneidge; Richard Jove
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7319-24.
2001: Pearlie K Epling-Burnette; Bin Zhong; Fanqi Bai; Kun Jiang; Ratna D Bailey; R Garcia; Richard Jove; Julie Y Djeu; Thomas P Loughran; Sheng Wei
Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7486-95.
2001: Roy Garcia; Tammy Bowman; Guilian Niu; Hua Yu; Susan Minton; Carlos Muro-Cacho; C E Cox; R Falcone; R Fairclough; S Parsons; A Laudano; A Gazit; Alexander Levitzki; Alan J Kraker; Richard Jove
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.
Oncogene 2001;20(20):2499-513.
2001: Guilian Niu; Kenneth Shain; Mei Huang; Rajani Ravi; Atul Bedi; William S Dalton; Richard Jove; Hua Yu
Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest.
Cancer research 2001;61(8):3276-80.
2001: T Sakai; Richard Jove; R Fässler; D F Mosher
Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3808-13.
2001: Pearlie K Epling-Burnette; J H Liu; Robyn Catlett-Falcone; James Turkson; MM Oshiro; Ravi Kothapalli; Y Li; J M Wang; H F Yang-Yen; James Karras; Richard Jove; Thomas P Loughran
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
The Journal of clinical investigation 2001;107(3):351-62.
2000: James Turkson; Richard Jove
STAT proteins: novel molecular targets for cancer drug discovery.
Oncogene 2000;19(56):6613-26.
2000: Dominic Sinibaldi; Walker Wharton; James Turkson; Tammy Bowman; Warren Pledger; Richard Jove
Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling.
Oncogene 2000;19(48):5419-27.
2000: Y Zhang; James Turkson; Christin Carter-Su; Thomas E Smithgall; Alexander Levitzki; Alan J Kraker; J J Krolewski; P Medveczky; Richard Jove
Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of Jak1 kinase activity.
The Journal of biological chemistry 2000;275(32):24935-44.
2000: Jay F Dorsey; Richard Jove; Alan J Kraker; Jie Wu
The pyrido[2,3-d]pyrimidine derivative PD180970 inhibits p210Bcr-Abl tyrosine kinase and induces apoptosis of K562 leukemic cells.
Cancer research 2000;60(12):3127-31.
2000: Tammy Bowman; Roy Garcia; James Turkson; Richard Jove
STATs in oncogenesis.
Oncogene 2000;19(21):2474-88.
2000: Richard Jove
Preface: STAT signaling.
Oncogene 2000;19(21):2466-7.
2000: Y Z Wang; Walker Wharton; Roy Garcia; Alan J Kraker; Richard Jove; Warren Pledger
Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activity.
Oncogene 2000;19(17):2075-85.
1999: Troy Lund; C Coleman; Elizabeth Horvath; Bartholomew M Sefton; Richard Jove; Maria M Medveczky; Peter G Medveczky
The Src-family kinase Lck can induce STAT3 phosphorylation and DNA binding activity.
Cellular signalling 1999;11(11):789-96.
1999: Robyn Catlett-Falcone; William S Dalton; Richard Jove
STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription.
Current opinion in oncology 1999;11(6):490-6.
1999: James Turkson; Tammy Bowman; J Adnane; Y Zhang; Julie Y Djeu; Madhavi Sekharam; David A Frank; Lawrence B Holzman; Jie Wu; Said Sebti; Richard Jove
Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein.
Molecular and cellular biology 1999;19(11):7519-28.
1999: Guilian Niu; Richard Heller; Robyn Catlett-Falcone; Domenico Coppola; M Jaroszeski; William Dalton; Richard Jove; Hua Yu
Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo.
Cancer research 1999;59(20):5059-63.
1999: W S Dalton; Richard Jove
Drug resistance in multiple myeloma: approaches to circumvention.
Seminars in oncology 1999;26(5 Suppl 13):23-7.
1999: Rotem Karni; Richard Jove; Alexander Levitzki
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors.
Oncogene 1999;18(33):4654-62.
1999: RP de Groot; Jan A M Raaijmakers; Jan-Willem J Lammers; Richard Jove; Leo Koenderman
STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells.
Blood 1999;94(3):1108-12.
1999: Kenneth Shain; Richard Jove; Nancy Olashaw
Constitutive RelB activation in v-Src-transformed fibroblasts: requirement for IkappaB degradation.
Journal of cellular biochemistry 1999;73(2):237-47.
1999: RY Liu; C Fan; R Garcia; Richard Jove; Kenneth S Zuckerman
Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines.
Blood 1999;93(7):2369-79.
1999: Rosalyn B Irby; W Mao; Domenico Coppola; J Kang; J M Loubeau; W Trudeau; Richard C Karl; D J Fujita; Richard Jove; Timothy J Yeatman
Activating SRC mutation in a subset of advanced human colon cancers.
Nature genetics 1999;21(2):187-90.
1999: Joung H Lee; Jyoti Harwalkar; S S Bryant; V Sundaram; Richard Jove; Mladen Golubic
Inhibition of neurofibromin and p120 GTPase activating protein (GAP) by dietary fatty acids.
Advances in experimental medicine and biology 1999;469():391-8.
1999: Robyn Catlett-Falcone; Terry Landowski; MM Oshiro; James Turkson; Alexander Levitzki; Rocco Savino; Gennaro Ciliberto; Lynn Moscinski; J L Fernández-Luna; G Nuñez; William S Dalton; Richard Jove
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells.
Immunity 1999;10(1):105-15.
1998: A X Liu; J R Testa; T C Hamilton; Richard Jove; S V Nicosia; J Q Cheng
AKT2, a member of the protein kinase B family, is activated by growth factors, v-Ha-ras, and v-src through phosphatidylinositol 3-kinase in human ovarian epithelial cancer cells.
Cancer research 1998;58(14):2973-7.
1998: Jess M Cunnick; Jay F Dorsey; T Standley; James Turkson; Alan J Kraker; David W Fry; Richard Jove; Jie Wu
Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway.
The Journal of biological chemistry 1998;273(23):14468-75.
1998: James Turkson; Tammy Bowman; Roy Garcia; E Caldenhoven; RP de Groot; Richard Jove
Stat3 activation by Src induces specific gene regulation and is required for cell transformation.
Molecular and cellular biology 1998;18(5):2545-52.
1998: K L Nelson; JA Rogers; T L Bowman; Richard Jove; Thomas E Smithgall
Activation of STAT3 by the c-Fes protein-tyrosine kinase.
The Journal of biological chemistry 1998;273(12):7072-7.
1998: S Iravani; W Mao; L Fu; Richard C Karl; Timothy J Yeatman; Richard Jove; Domenico Coppola
Elevated c-Src protein expression is an early event in colonic neoplasia.
Laboratory investigation; a journal of technical methods and pathology 1998;78(3):365-71.
1998: Roy Garcia; Richard Jove
Activation of STAT transcription factors in oncogenic tyrosine kinase signaling.
Journal of biomedical science 1998;5(2):79-85.
1998: M Golubić; Jyoti Harwalkar; S S Bryant; V Sundaram; Richard Jove; Joung H Lee
Differential regulation of neurofibromin and p120 GTPase-activating protein by nutritionally relevant fatty acids.
Nutrition and cancer 1998;30(2):97-107.
1997: W Mao; Rosalyn B Irby; Domenico Coppola; L Fu; M Wloch; J Turner; H Yu; R Garcia; Richard Jove; Timothy J Yeatman
Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential.
Oncogene 1997;15(25):3083-90.
1997: Chao-Lan Yu; Richard Jove; Steven J Burakoff
Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5206-10.
1997: Rosalyn B Irby; W Mao; Domenico Coppola; Richard Jove; A Gamero; David Cuthbertson; D J Fujita; Timothy J Yeatman
Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(12):1287-95.
1997: Roy Garcia; C L Yu; A Hudnall; R Catlett; K L Nelson; Thomas E Smithgall; D J Fujita; Stephen Ethier; Richard Jove
Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(12):1267-76.
1997: Troy Lund; R Garcia; Maria M Medveczky; Richard Jove; Peter G Medveczky
Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck.
Journal of virology 1997;71(9):6677-82.
1997: Carolyn I Sartor; Michele L Dziubinski; CL Yu; Richard Jove; Stephen Ethier
Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells.
Cancer research 1997;57(5):978-87.
1997: L F Stancato; AM Silverstein; J K Owens-Grillo; Y H Chow; Richard Jove; William B Pratt
The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase.
The Journal of biological chemistry 1997;272(7):4013-20.
1997: GS Campbell; CL Yu; Richard Jove; Christin Carter-Su
Constitutive activation of JAK1 in Src-transformed cells.
The Journal of biological chemistry 1997;272(5):2591-4.
1997: MR Stofega; CL Yu; Jie Wu; Richard Jove
Activation of extracellular signal-regulated kinase (ERK) by mitogenic stimuli is repressed in v-Src-transformed cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(1):113-9.
1996: S S Bryant; A L Mitchell; F Collins; W Miao; M Marshall; Richard Jove
N-terminal sequences contained in the Src homology 2 and 3 domains of p120 GTPase-activating protein are required for full catalytic activity toward Ras.
The Journal of biological chemistry 1996;271(9):5195-9.
1995: C L Yu; Edward V Prochownik; Richard Jove
Proximal promoter region of the junB gene mediates attenuation of serum inducibility in Src-transformed cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1513-21.
1995: S S Bryant; SD Briggs; Thomas E Smithgall; G A Martin; F McCormick; J H Chang; S J Parsons; Richard Jove
Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein.
The Journal of biological chemistry 1995;270(30):17947-52.
1995: C L Yu; D J Meyer; G S Campbell; Andrew C Larner; Christin Carter-Su; Jessica Schwartz; Richard Jove
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein.
Science (New York, N.Y.) 1995;269(5220):81-3.
1995: H Yu; SJ Suchard; R Nairn; Richard Jove
Dissociation of mitogen-activated protein kinase activation from the oxidative burst in differentiated HL-60 cells and human neutrophils.
The Journal of biological chemistry 1995;270(26):15719-24.
1995: SD Briggs; S S Bryant; Richard Jove; Sam D Sanderson; Thomas E Smithgall
The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck.
The Journal of biological chemistry 1995;270(24):14718-24.
1995: Kevin Pumiglia; Harry LeVine; T Haske; T Habib; Richard Jove; S J Decker
A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase.
The Journal of biological chemistry 1995;270(24):14251-4.
1995: Y H Chow; Kevin Pumiglia; T H Jun; P Dent; Thomas W Sturgill; Richard Jove
Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase.
The Journal of biological chemistry 1995;270(23):14100-6.
1995: Kevin Pumiglia; Y H Chow; J Fabian; D Morrison; S Decker; Richard Jove
Raf-1 N-terminal sequences necessary for Ras-Raf interaction and signal transduction.
Molecular and cellular biology 1995;15(1):398-406.
1994: P Dent; Y H Chow; Jie Wu; Deborah K Morrison; Richard Jove; Thomas W Sturgill
Expression, purification and characterization of recombinant mitogen-activated protein kinase kinases.
The Biochemical journal 1994;303 ( Pt 1)():105-12.
1994: LF Stancato; Y H Chow; J K Owens-Grillo; Anthony W Yem; M R Deibel; Richard Jove; William B Pratt
The native v-Raf.hsp90.p50 heterocomplex contains a novel immunophilin of the FK506 binding class.
The Journal of biological chemistry 1994;269(35):22157-61.
1993: S Park; Richard Jove
Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells.
The Journal of biological chemistry 1993;268(34):25728-34.
1993: LF Stancato; Y H Chow; K A Hutchison; G H Perdew; Richard Jove; William B Pratt
Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.
The Journal of biological chemistry 1993;268(29):21711-6.
1993: K A Hutchison; L C Scherrer; Michael J Czar; LF Stancato; Y H Chow; Richard Jove; William B Pratt
Regulation of glucocorticoid receptor function through assembly of a receptor-heat shock protein complex.
Annals of the New York Academy of Sciences 1993;684():35-48.
1993: P E Gregory; David H Gutmann; A Mitchell; S Park; M Boguski; T Jacks; D L Wood; Richard Jove; Francis S Collins
Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules.
Somatic cell and molecular genetics 1993;19(3):265-74.
1993: C L Yu; Edward V Prochownik; Michael J Imperiale; Richard Jove
Attenuation of serum inducibility of immediate early genes by oncoproteins in tyrosine kinase signaling pathways.
Molecular and cellular biology 1993;13(4):2011-9.
1992: T Redmond; B K Brott; Richard Jove; Michael J Welsh
Localization of the viral and cellular Src kinases to perinuclear vesicles in fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(9):567-76.
1992: S Park; X Liu; T Pawson; Richard Jove
Activated Src tyrosine kinase phosphorylates Tyr-457 of bovine GTPase-activating protein (GAP) in vitro and the corresponding residue of rat GAP in vivo.
The Journal of biological chemistry 1992;267(24):17194-200.
1992: Ingrid J Apel; C L Yu; T Wang; C Dobry; M E Van Antwerp; Richard Jove; Edward V Prochownik
Regulation of the junB gene by v-src.
Molecular and cellular biology 1992;12(8):3356-64.
1992: K A Hutchison; LF Stancato; Richard Jove; William B Pratt
The protein-protein complex between pp60v-src and hsp90 is stabilized by molybdate, vanadate, tungstate, and an endogenous cytosolic metal.
The Journal of biological chemistry 1992;267(20):13952-7.
1992: S Park; M S Marshall; J B Gibbs; Richard Jove
Reconstitution of interactions between the Src tyrosine kinases and Ras GTPase-activating protein using a baculovirus expression system.
The Journal of biological chemistry 1992;267(16):11612-8.
1992: K A Hutchison; B K Brott; J H De Leon; G H Perdew; Richard Jove; William B Pratt
Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.
The Journal of biological chemistry 1992;267(5):2902-8.
1991: B K Brott; S Decker; M C O'Brien; Richard Jove
Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein.
Molecular and cellular biology 1991;11(10):5059-67.
1991: B K Brott; S Decker; J Shafer; J B Gibbs; Richard Jove
GTPase-activating protein interactions with the viral and cellular Src kinases.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):755-9.
1989: Richard Jove; T Hanafusa; M Hamaguchi; Hidesaburo Hanafusa
In vivo phosphorylation states and kinase activities of transforming p60c-src mutants.
Oncogene research 1989;5(1):49-60.
1987: Richard Jove; Sally Kornbluth; H Hanafusa
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region.
Cell 1987;50(6):937-43.
1987: Sally Kornbluth; Richard Jove; H Hanafusa
Characterization of avian and viral p60src proteins expressed in yeast.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(13):4455-9.
1987: D S Grass; Richard Jove; J L Manley
RNA polymerase II terminates transcription in vitro in the SV40 origin region.
Nucleic acids research 1987;15(11):4417-36.
1987: Georges Calothy; Danielle Laugier; F R Cross; Richard Jove; T Hanafusa; H Hanafusa
The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation.
Journal of virology 1987;61(5):1678-81.
1987: E A Garber; B J Mayer; Richard Jove; H Hanafusa
Analysis of p60v-src mutants carrying lesions involved in temperature sensitivity.
Journal of virology 1987;61(2):354-60.
1987: Richard Jove; Hidesaburo Hanafusa
Cell transformation by the viral src oncogene.
Annual review of cell biology 1987;3():31-56.
1986: B J Mayer; Richard Jove; J F Krane; F Poirier; Georges Calothy; H Hanafusa
Genetic lesions involved in temperature sensitivity of the src gene products of four Rous sarcoma virus mutants.
Journal of virology 1986;60(3):858-67.
1986: Richard Jove; E A Garber; H Iba; H Hanafusa
Biochemical properties of p60v-src mutants that induce different cell transformation parameters.
Journal of virology 1986;60(3):849-57.
1986: Richard Jove; B J Mayer; H Iba; Danielle Laugier; F Poirier; Georges Calothy; T Hanafusa; H Hanafusa
Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters.
Journal of virology 1986;60(3):840-8.