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Santiago Cal

Research Profile

Chemicals & Drugs

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Publications

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Rocio G Urdinguio; Teresa Bernal; Felix Bonilla; Santiago Cal; Gemma Dominguez; Agustin F Fernandez; Cecilia Ferrero; Covadonga Huidobro; Carlos Lopez-Otin; Pablo Martinez-Camblor; Xavier Matias-Guiu; Angela Moncada-Pazos; Alvaro J Obaya; Adolfo Parra-Blanco; Luis Rodrigo; Ramon M Rodriguez; Maria Santacana; Beatriz Soldevilla; Mario F Fraga
Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.
Alvaro J Obaya; Susana Rua; Angela Moncada-Pazos; Santiago Cal
The dual role of fibulins in tumorigenesis.
Angela Moncada-Pazos; Agnès Noël; Alvaro J Obaya; María F Suárez; Santiago Cal; Enrique Colado; Ritva Heljasvaara; Maria Llamazares; Carlos López-Otín
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.

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All Publications

2013: Rocio G Urdinguio; Teresa Bernal; Felix Bonilla; Santiago Cal; Gemma Dominguez; Agustin F Fernandez; Cecilia Ferrero; Covadonga Huidobro; Carlos Lopez-Otin; Pablo Martinez-Camblor; Xavier Matias-Guiu; Angela Moncada-Pazos; Alvaro J Obaya; Adolfo Parra-Blanco; Luis Rodrigo; Ramon M Rodriguez; Maria Santacana; Beatriz Soldevilla; Mario F Fraga
Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors.
Cancer research 2013;73(1):395-405.
2012: Alvaro J Obaya; Susana Rua; Angela Moncada-Pazos; Santiago Cal
The dual role of fibulins in tumorigenesis.
Cancer letters 2012;325(2):132-8.
2012: Angela Moncada-Pazos; Agnès Noël; Alvaro J Obaya; María F Suárez; Santiago Cal; Enrique Colado; Ritva Heljasvaara; Maria Llamazares; Carlos López-Otín
ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
The Journal of biological chemistry 2012;287(47):39554-63.
2012: Agnès Noel; Nor Eddine SOUNNI; Ida K Lund; Erik Maquoi; Niels Behrendt; Santiago Cal; Ana Gutiérrez-Fernández; Gunilla Hoyer-Hansen; Carlos López-Otín
New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.
Frontiers in pharmacology 2012;3():140.
2011: Angela Moncada-Pazos; Alvaro J Obaya; Cristina G Viloria; Carlos López-Otín; Santiago Cal
The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.
Journal of molecular medicine (Berlin, Germany) 2011;89(6):611-9.
2009: Angela Moncada-Pazos; Alvaro J Obaya; Mario F Fraga; Cristina G Viloria; Gabriel Capellá; Mireia Gausachs; Manel Esteller; Carlos López-Otín; Santiago Cal
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
Journal of cell science 2009;122(Pt 16):2906-13.
2009: Cristina G Viloria; Alvaro J Obaya; Angela Moncada-Pazos; María Llamazares; AURORA ASTUDILLO; Gabriel Capellá; Santiago Cal; Carlos López-Otín
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.
Cancer research 2009;69(11):4926-34.
2007: Maria Llamazares; Alvaro J Obaya; Angela Moncada-Pazos; Ritva Heljasvaara; Jesús Espada; Carlos López-Otín; Santiago Cal
The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.
Journal of cell science 2007;120(Pt 20):3544-52.
2007: Cristina G Viloria; Juan Peinado; AURORA ASTUDILLO; Olivia García-Suárez; M V González; C Suárez; Santiago Cal
Human DESC1 serine protease confers tumorigenic properties to MDCK cells and it is upregulated in tumours of different origin.
British journal of cancer 2007;97(2):201-9.
2007: Santiago Cal; Angela Moncada-Pazos; Carlos Lopez-Otin
Expanding the complexity of the human degradome: polyserases and their tandem serine protease domains.
Frontiers in bioscience : a journal and virtual library 2007;12():4661-9.
2006: L González; José M P Freije; Santiago Cal; Carlos López-Otín; M Serrano; Ignacio Palmero
A functional link between the tumour suppressors ARF and p33ING1.
Oncogene 2006;25(37):5173-9.
2006: Santiago Cal; Juan Peinado; Maria Llamazares; Víctor Quesada; Angela Moncada-Pazos; Cecilia Garabaya; Carlos López-Otín
Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain.
BMC biochemistry 2006;7():9.
2005: Zhenyin Tao; Yuandong Peng; Leticia Nolasco; Santiago Cal; Carlos Lopez-Otin; Renhao Li; Joel L Moake; José A López; Jing-fei Dong
Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Blood 2005;106(13):4139-45.
2005: Santiago Cal; Víctor Quesada; Maria Llamazares; Araceli Díaz-Perales; Cecilia Garabaya; Carlos López-Otín
Human polyserase-2, a novel enzyme with three tandem serine protease domains in a single polypeptide chain.
The Journal of biological chemistry 2005;280(3):1953-61.
2004: Víctor Quesada; Araceli Díaz-Perales; Ana Gutiérrez-Fernández; Cecilia Garabaya; Santiago Cal; Carlos López-Otín
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases.
Biochemical and biophysical research communications 2004;314(1):54-62.
2003: Santiago Cal; Víctor Quesada; Cecilia Garabaya; Carlos Lopez-Otin
Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(16):9185-90.
2003: Maria Llamazares; Santiago Cal; Víctor Quesada; Carlos López-Otín
Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.
The Journal of biological chemistry 2003;278(15):13382-9.
2002: Gloria Velasco; Santiago Cal; Víctor Quesada; Luis M Sánchez; Carlos López-Otín
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.
The Journal of biological chemistry 2002;277(40):37637-46.
2002: Santiago Cal; Alvaro J Obaya; Maria Llamazares; Cecilia Garabaya; Víctor Quesada; Carlos López-Otín
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Gene 2002;283(1-2):49-62.
2001: Santiago Cal; J M Arguelles; Pedro L Fernandez; Carlos López-Otín
Identification, characterization, and intracellular processing of ADAM-TS12, a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.
The Journal of biological chemistry 2001;276(21):17932-40.
2000: Santiago Cal; José M P Freije; J M López; Yoshikazu Takada; Carlos López-Otín
ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism.
Molecular biology of the cell 2000;11(4):1457-69.
2000: Gloria Velasco; Santiago Cal; Anna Merlos-Suárez; Adolfo Ferrando; S Alvarez; A Nakano; Joaquín Arribas; Carlos López-Otín
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.
Cancer research 2000;60(4):877-82.