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Orhan Aktas

Research Profile

Disorders

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Frédéric Ebstein; Peter-M Kloetzel; Orhan Aktas; Ulrike Kuckelkorn; Nicole Lange; Timour Prozorovski; Friederike Schröter; Ulrike Seifert; Antje Voigt; Annika Warnatsch; Elke Krüger
Immunoproteasomes are important for proteostasis in immune responses.
Katharina Schregel; Jens Wuerfel; Eva Wuerfel; Orhan Aktas; Philippe Garteiser; Ines Gemeinhardt; Hartmut Merz; Dirk Petersen; Timour Prozorovski; Ralph Sinkus
Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography.
Timm Oberwahrenbrock; Friedemann Paul; Marius Ringelstein; S Schippling; Kim Lea Young; Hanna Zimmermann; Jens Harmel; Hans-Peter Hartung; Falko Kaufhold; Nazmiye Keser; Roland Martin; Orhan Aktas; Alexander U Brandt
Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography.

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All Publications

2013: Frédéric Ebstein; Peter-M Kloetzel; Orhan Aktas; Ulrike Kuckelkorn; Nicole Lange; Timour Prozorovski; Friederike Schröter; Ulrike Seifert; Antje Voigt; Annika Warnatsch; Elke Krüger
Immunoproteasomes are important for proteostasis in immune responses.
Cell 2013;152(5):935-7.
2012: Katharina Schregel; Jens Wuerfel; Eva Wuerfel; Orhan Aktas; Philippe Garteiser; Ines Gemeinhardt; Hartmut Merz; Dirk Petersen; Timour Prozorovski; Ralph Sinkus
Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):6650-5.
2012: Timm Oberwahrenbrock; Friedemann Paul; Marius Ringelstein; S Schippling; Kim Lea Young; Hanna Zimmermann; Jens Harmel; Hans-Peter Hartung; Falko Kaufhold; Nazmiye Keser; Roland Martin; Orhan Aktas; Alexander U Brandt
Retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography.
Multiple sclerosis international 2012;2012():530305.
2012: Alexander U Brandt; Orhan Aktas; David Finis; Christian Geis; Hans-Peter Hartung; Falko Kaufhold; Ilka Kleffner; Friedemann Paul; Julia Promesberger; E Bernd Ringelstein; Marius Ringelstein; S Schippling; Hanna Zimmermann; Jan Dörr
Patterns of retinal damage facilitate differential diagnosis between Susac syndrome and MS.
PloS one 2012;7(6):e38741.
2011: Katja Herges; Carmen Infante-Duarte; Jason M Millward; Orhan Aktas; Nicole Hentschel; Frauke Zipp
Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation.
PloS one 2011;6(10):e25456.
2011: Petra Huehnchen; Timour Prozorovski; Philipp Klaissle; Anne Lesemann; Jens Ingwersen; Susanne Wolf; Andreas Kupsch; Orhan Aktas; Barbara Steiner
Modulation of adult hippocampal neurogenesis during myelin-directed autoimmune neuroinflammation.
Glia 2011;59(1):132-42.
2010: Ulrike Seifert; Lukasz P Bialy; Frédéric Ebstein; Dawadschargal Bech-Otschir; Antje Voigt; Friederike Schröter; Timour Prozorovski; Nicole Lange; Janos Steffen; Melanie Rieger; Ulrike Kuckelkorn; Orhan Aktas; Peter-M Kloetzel; Elke Krüger
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress.
Cell 2010;142(4):613-24.
2009: Johannes Vogt; Friedemann Paul; Orhan Aktas; Kathrin Müller-Wielsch; Jan Dörr; Susanne Dörr; B Suman Bharathi; Robert Glumm; Christoph Schmitz; Harry Steinbusch; Cedric S Raine; Michael Tsokos; Robert Nitsch; Frauke Zipp
Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis.
Annals of neurology 2009;66(3):310-22.
2009: Judith Bellmann-Strobl; H Stiepani; Jens Wuerfel; Georg Bohner; Friedemann Paul; Carsten Warmuth; Orhan Aktas; Klaus-Peter Wandinger; Frauke Zipp; Randolf Klingebiel
MR spectroscopy (MRS) and magnetisation transfer imaging (MTI), lesion load and clinical scores in early relapsing remitting multiple sclerosis: a combined cross-sectional and longitudinal study.
European radiology 2009;19(8):2066-74.
2009: Ulf Schulze Topphoff; Alexandre Prat; Timour Prozorovski; Volker Siffrin; Magdalena Paterka; Josephine Herz; Ivo Bendix; Igal Ifergan; Ines Schadock; Marcelo A Mori; Jack Van Horssen; Friederike Schröter; Alina Smorodchenko; May Htwe Han; Michael Bader; Lawrence Steinman; Orhan Aktas; Frauke Zipp
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system.
Nature medicine 2009;15(7):788-93.
2009: Eva Tysiak; Patrick Asbach; Orhan Aktas; Helmar Waiczies; Maureen Smyth; Joerg Schnorr; Matthias Taupitz; Jens Wuerfel
Beyond blood brain barrier breakdown - in vivo detection of occult neuroinflammatory foci by magnetic nanoparticles in high field MRI.
Journal of neuroinflammation 2009;6():20.
2008: Friedemann Paul; Sven Jarius; R Glumm; Brigitte Wildemann; Frauke Zipp; Orhan Aktas
[Recent findings in pathogenesis, diagnostics and therapy of neuromyelitis optica].
Deutsche medizinische Wochenschrift (1946) 2008;133(21):1125-9.
2008: Ulf Schulze Topphoff; A Prat; M Bader; Frauke Zipp; Orhan Aktas
Roles of the kallikrein/kinin system in the adaptive immune system.
International immunopharmacology 2008;8(2):155-60.
2008: Friedemann Paul; Sonia Waiczies; Jens Wuerfel; Judith Bellmann-Strobl; Jan Dörr; Helmar Waiczies; Mareile Haertle; Klaus-Dieter Wernecke; Hans-Dieter Volk; Orhan Aktas; Frauke Zipp
Oral high-dose atorvastatin treatment in relapsing-remitting multiple sclerosis.
PloS one 2008;3(4):e1928.
2007: Friedemann Paul; Christian Veauthier; Georg Fritz; Thomas-Nicolas Lehmann; Orhan Aktas; Frauke Zipp; Heinz-Joachim Meencke
Perioperative fluctuations of lamotrigine serum levels in patients undergoing epilepsy surgery.
Seizure : the journal of the British Epilepsy Association 2007;16(6):479-84.
2007: Frauke Zipp; Sonia Waiczies; Orhan Aktas; Oliver Neuhaus; Bernhard Hemmer; Burkhard Schraven; Robert Nitsch; Hans-Peter Hartung
Impact of HMG-CoA reductase inhibition on brain pathology.
Trends in pharmacological sciences 2007;28(7):342-9.
2007: Olaf Hoffmann; Josef Priller; Timour Prozorovski; Ulf Schulze Topphoff; Nevena Baeva; Jan D Lunemann; Orhan Aktas; Cordula Mahrhofer; Sigmar Stricker; Frauke Zipp; Joerg R Weber
TRAIL limits excessive host immune responses in bacterial meningitis.
The Journal of clinical investigation 2007;117(7):2004-13.
2007: Sven Jarius; Friedemann Paul; Diego Franciotta; Orhan Aktas; Reinhard Hohlfeld; Frauke Zipp; Angela Vincent
Revised diagnostic criteria for neuromyelitis optica--incorporation of NMO-IgG status.
Nature clinical practice. Neurology 2007;3(5):E1.
2007: Friedemann Paul; Sven Jarius; Orhan Aktas; Martin Bluthner; Oliver Bauer; Heribert Appelhans; Diego Franciotta; Roberto Bergamaschi; Edward Littleton; Jacqueline Palace; Hans-Peter Seelig; Reinhard Hohlfeld; Angela Vincent; Frauke Zipp
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
PLoS medicine 2007;4(4):e133.
2007: Leman K Mutlu; Christine Brandt; Erik Kwidzinski; Birgit Sawitzki; Ulrike Gimsa; Jacqueline Mahlo; Orhan Aktas; Robert Nitsch; Marloes van Zwam; Jon D Laman; Ingo Bechmann
Tolerogenic effect of fiber tract injury: reduced EAE severity following entorhinal cortex lesion.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 2007;178(4):542-53.
2007: Orhan Aktas; Sonia Waiczies; Frauke Zipp
Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets.
Journal of neuroimmunology 2007;184(1-2):17-26.
2007: Orhan Aktas; Oliver Ullrich; Carmen Infante-Duarte; Robert Nitsch; Frauke Zipp
Neuronal damage in brain inflammation.
Archives of neurology 2007;64(2):185-9.
2007: Orhan Aktas; Ulf Schulze Topphoff; Frauke Zipp
The role of TRAIL/TRAIL receptors in central nervous system pathology.
Frontiers in bioscience : a journal and virtual library 2007;12():2912-21.
2006: Frauke Zipp; Orhan Aktas
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases.
Trends in neurosciences 2006;29(9):518-27.
2006: Orhan Aktas; Timour Prozorovski; Frauke Zipp
Death ligands and autoimmune demyelination.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2006;12(4):305-16.
2006: Friedemann Paul; Orhan Aktas; F-J Dieste; P Kreitsch; HP Vogel; Frauke Zipp
[Relapsing reversible posterior leukoencephalopathy after chemotherapy with cisplatin and 5-fluorouracil].
Der Nervenarzt 2006;77(6):706-10.
2005: Carmen Infante-Duarte; Alexandra Weber; Jörn Krätzschmar; Timour Prozorovski; Susan Pikol; Isabell Hamann; Judith Bellmann-Strobl; Orhan Aktas; Jan Dörr; Jens Wuerfel; Claus-Steffen Stürzebecher; Frauke Zipp
Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(13):1902-4.
2005: Erik Kwidzinski; Jörg Bunse; Orhan Aktas; Daniel Richter; Leman K Mutlu; Frauke Zipp; Robert Nitsch; Ingo Bechmann
Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1347-9.
2005: Orhan Aktas; Alina Smorodchenko; Stefan Brocke; Carmen Infante-Duarte; Ulf Schulze Topphoff; Johannes Vogt; Timour Prozorovski; Susanne Meier; Venera Osmanova; Elena Pohl; Ingo Bechmann; Robert Nitsch; Frauke Zipp
Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.
Neuron 2005;46(3):421-32.
2005: Sonia Waiczies; Timour Prozorovski; Carmen Infante-Duarte; Astrid Hahner; Orhan Aktas; Oliver Ullrich; Frauke Zipp
Atorvastatin induces T cell anergy via phosphorylation of ERK1.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5630-5.
2004: Orhan Aktas; Timour Prozorovski; Alina Smorodchenko; Nicolai E Savaskan; Roland Lauster; Peter-M Kloetzel; Carmen Infante-Duarte; Stefan Brocke; Frauke Zipp
Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5794-800.
2004: Klaus Schmierer; Daniel R Altmann; Nadja Kassim; Hagen Kitzler; Christian M Kerskens; Claudia A Doege; Orhan Aktas; Jan D Lünemann; David H Miller; Frauke Zipp; Arno Villringer
Progressive change in primary progressive multiple sclerosis normal-appearing white matter: a serial diffusion magnetic resonance imaging study.
Multiple sclerosis (Houndmills, Basingstoke, England) 2004;10(2):182-7.
2004: Alexandra Weber; Klaus-Peter Wandinger; Wolf Mueller; Orhan Aktas; Oliver Wengert; Eva Grundström; Stefan Ehrlich; Christine Windemuth; Tanja Kuhlmann; Thomas F Wienker; Wolfgang Brück; Frauke Zipp
Identification and functional characterization of a highly polymorphic region in the human TRAIL promoter in multiple sclerosis.
Journal of neuroimmunology 2004;149(1-2):195-201.
2004: Robert Nitsch; Elena E Pohl; Alina Smorodchenko; Carmen Infante-Duarte; Orhan Aktas; Frauke Zipp
Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(10):2458-64.
2004: Jens Wuerfel; Judith Bellmann-Strobl; Peter Brunecker; Orhan Aktas; Henry McFarland; Arno Villringer; Frauke Zipp
Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study.
Brain : a journal of neurology 2004;127(Pt 1):111-9.
2003: Antje Diestel; Orhan Aktas; Dagmar Hackel; Ines Hake; Susanne Meier; Cedric S Raine; Robert Nitsch; Frauke Zipp; Oliver Ullrich
Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage.
The Journal of experimental medicine 2003;198(11):1729-40.
2003: Klaus-Peter Wandinger; Jan D Lünemann; Oliver Wengert; Judith Bellmann-Strobl; Orhan Aktas; Alexandra Weber; Eva Grundström; Stefan Ehrlich; Klaus-Dieter Wernecke; Hans-Dieter Volk; Frauke Zipp
TNF-related apoptosis inducing ligand (TRAIL) as a potential response marker for interferon-beta treatment in multiple sclerosis.
Lancet 2003;361(9374):2036-43.
2003: Paul Gniadek; Orhan Aktas; Klaus-Peter Wandinger; Judith Bellmann-Strobl; Oliver Wengert; Alexandra Weber; Peter von Wussow; Hans-Jürgen Obert; Frauke Zipp
Systemic IFN-beta treatment induces apoptosis of peripheral immune cells in MS patients.
Journal of neuroimmunology 2003;137(1-2):187-96.
2003: Orhan Aktas; Sonia Waiczies; Alina Smorodchenko; Jan Dorr; Bibiane Seeger; Timour Prozorovski; Stephanie Sallach; Matthias Endres; Stefan Brocke; Robert Nitsch; Frauke Zipp
Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin.
The Journal of experimental medicine 2003;197(6):725-33.
2003: Maike Rieks; Volker Hoffmann; Orhan Aktas; Miriam Juschka; Iris Spitzer; Nils Brune; Sebastian Schimrigk; Horst Przuntek; Dieter Pöhlau
Induction of apoptosis of CD4+ T cells by immunomodulatory therapy of multiple sclerosis with glatiramer acetate.
European neurology 2003;50(4):200-6.
2003: Erik Kwidzinski; Leman K Mutlu; Adam D Kovac; Jörg Bunse; Jana Goldmann; Jacqueline Mahlo; Orhan Aktas; F Zipp; T Kamradt; Robert Nitsch; Ingo Bechmann
Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model.
Journal of neural transmission. Supplementum 2003;(65):29-49.
2003: Orhan Aktas; Frauke Zipp
Regulation of self-reactive T cells by human immunoglobulins--implications for multiple sclerosis therapy.
Current pharmaceutical design 2003;9(3):245-56.
2002: Sonia Waiczies; Alexandra Weber; Jan D Lünemann; Orhan Aktas; Rolf Zschenderlein; Frauke Zipp
Elevated Bcl-X(L) levels correlate with T cell survival in multiple sclerosis.
Journal of neuroimmunology 2002;126(1-2):213-20.
2002: Jan Dörr; Ingo Bechmann; Sonia Waiczies; Orhan Aktas; Henning Walczak; Peter H Krammer; Robert Nitsch; Frauke Zipp
Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(4):RC209.
2002: Frauke Zipp; Orhan Aktas; Jan D Lünemann
The role of apoptosis in neuroinflammation.
Ernst Schering Research Foundation workshop 2002;(39):213-29.
2001: Orhan Aktas; N Ari; Maike Rieks; V Hoffmann; Sebastian Schimrigk; Horst Przuntek; Dieter Pöhlau
Multiple sclerosis: modulation of apoptosis susceptibility by glatiramer acetate.
Acta neurologica Scandinavica 2001;104(5):266-70.
2001: Jan D Lünemann; Orhan Aktas; P Gniadek; Rolf Zschenderlein; Frauke Zipp
Downregulation of transforming growth factor-beta1 in interferon-beta1a-treated MS patients.
Neurology 2001;57(6):1132-4.
2001: Orhan Aktas; Sonia Waiczies; U Grieger; Uwe Wendling; Rolf Zschenderlein; Frauke Zipp
Polyspecific immunoglobulins (IVIg) suppress proliferation of human (auto)antigen-specific T cells without inducing apoptosis.
Journal of neuroimmunology 2001;114(1-2):160-7.
2000: Orhan Aktas; Uwe Wendling; Rolf Zschenderlein; Frauke Zipp
[Apoptosis in multiple sclerosis. Etiopathogenetic relevance and prospects for new therapeutic strategies].
Der Nervenarzt 2000;71(10):767-73.
2000: Uwe Wendling; Orhan Aktas; Klaus Schmierer; Rolf Zschenderlein; Frauke Zipp
Partial synergy of bisindolylmaleimide with apoptotic stimulus in antigen-specific T cells--implications for multiple sclerosis.
Journal of neuroimmunology 2000;103(1):69-75.
1998: Dieter Pöhlau; Orhan Aktas; C Epplen; H P Hartung; Volker Hoffmann; Horst Przuntek
[Promoting remyelination as a future therapeutic principle in multiple sclerosis?].
Der Nervenarzt 1998;69(10):841-50.