FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

John Pichardo

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Procedures

Genes & Molecular Sequences

Molecular Structure

Phenomena

Co-author Network

Publications

TOP 3
Xiao Tong; Ashok Arasappan; Frank Bennett; Robert Chase; B Feld; Zhuyan Guo; A Hart; Vincent Madison; Bruce A Malcolm; John Pichardo; Andrew Prongay; Robert Ralston; Angela Skelton; Ellen Xia; Rumin Zhang; F George Njoroge
Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
Frank Bennett; Yuhua Huang; Siska Hendrata; Raymond G Lovey; Stéphane L Bogen; Weidong Pan; Zhuyan Guo; Andrew Prongay; Kevin X Chen; Ashok Arasappan; Srikanth Venkatraman; Francisco Velazquez; Latha Nair; Mousumi Sannigrahi; Xiao Tong; John Pichardo; Kuo-Chi Cheng; Viyyoor Girijavallabhan; Anil K Saksena; F George Njoroge
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Srikanth Venkatraman; Mellissa Blackman; Wanli Wu; Latha Nair; Ashok Arasappan; Angela Padilla; Stéphane Bogen; Frank Bennett; Kevin Chen; John Pichardo; Xiao Tong; Andrew Prongay; Kuo-Chi Cheng; Viyyoor Girijavallabhan; F George Njoroge
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of John Pichardo (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2010: Xiao Tong; Ashok Arasappan; Frank Bennett; Robert Chase; B Feld; Zhuyan Guo; A Hart; Vincent Madison; Bruce A Malcolm; John Pichardo; Andrew Prongay; Robert Ralston; Angela Skelton; Ellen Xia; Rumin Zhang; F George Njoroge
Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
Antimicrobial agents and chemotherapy 2010;54(6):2365-70.
2010: Frank Bennett; Yuhua Huang; Siska Hendrata; Raymond G Lovey; Stéphane L Bogen; Weidong Pan; Zhuyan Guo; Andrew Prongay; Kevin X Chen; Ashok Arasappan; Srikanth Venkatraman; Francisco Velazquez; Latha Nair; Mousumi Sannigrahi; Xiao Tong; John Pichardo; Kuo-Chi Cheng; Viyyoor Girijavallabhan; Anil K Saksena; F George Njoroge
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorganic & medicinal chemistry letters 2010;20(8):2617-21.
2009: Srikanth Venkatraman; Mellissa Blackman; Wanli Wu; Latha Nair; Ashok Arasappan; Angela Padilla; Stéphane Bogen; Frank Bennett; Kevin Chen; John Pichardo; Xiao Tong; Andrew Prongay; Kuo-Chi Cheng; Viyyoor Girijavallabhan; F George Njoroge
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
Bioorganic & medicinal chemistry 2009;17(13):4486-95.
2009: Francisco Velázquez; Srikanth Venkatraman; Melissa Blackman; Patrick Pinto; Stéphane L Bogen; Mousumi Sannigrahi; Kevin Chen; John Pichardo; A Hart; Xiao Tong; Viyyoor Girijavallabhan; F George Njoroge
Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.
Journal of medicinal chemistry 2009;52(3):700-8.
2009: Srikanth Venkatraman; Francisco Velazquez; Wanli Wu; Melissa Blackman; Kevin X Chen; Stéphane L Bogen; Latha Nair; Xiao Tong; Robert Chase; A Hart; Sony Agrawal; John Pichardo; Andrew Prongay; Kuo-Chi Cheng; Viyyoor Girijavallabhan; John J Piwinski; Neng-Yang Shih; F George Njoroge
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
Journal of medicinal chemistry 2009;52(2):336-46.
2008: Vincent Madison; Andrew Prongay; Zhuyan Guo; Nanhua Yao; John Pichardo; Thierry Fischmann; Corey Strickland; Joseph Myers; Patricia C Weber; Brian M Beyer; Richard Ingram; Zhi Hong; Winifred W Prosise; Lata Ramanathan; S Shane Taremi; Taisa Yarosh-Tomaine; Rumin Zhang; Mary Senior; Rong Sheng Yang; Bruce Malcolm; Ashok Arasappan; Frank Bennett; Stephane L Bogen; Kevin Chen; Edwin Jao; Yi Tsung Liu; Raymond G Lovey; Anil K Saksena; Srikanth Venkatraman; Viyyoor Girijavallabhan; F George Njoroge
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034.
Journal of synchrotron radiation 2008;15(Pt 3):204-7.
2008: Cheng Li; Latha Nair; Tongtong Liu; Fangbiao Li; John Pichardo; Sony Agrawal; Robert Chase; Xiao Tong; Annette S Uss; Stéphane L Bogen; F George Njoroge; Richard A Morrison; Kuo-Chi Cheng
Correlation between PAMPA permeability and cellular activities of hepatitis C virus protease inhibitors.
Biochemical pharmacology 2008;75(5):1186-97.
2008: Kevin X Chen; Bancha Vibulbhan; Weiying Yang; Kuo-Chi Cheng; Rong Liu; John Pichardo; Nancy Butkiewicz; F George Njoroge
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue.
Bioorganic & medicinal chemistry 2008;16(4):1874-83.
2007: Lynn Miesel; Cynthia Kravec; Alan-Tianpei Xin; Patricia McMonagle; Sarah Ma; John Pichardo; Boris Feld; Ellen Barrabee; Robert Palermo
A high-throughput assay for the adenylation reaction of bacterial DNA ligase.
Analytical biochemistry 2007;366(1):9-17.
2007: Andrew Prongay; Zhuyan Guo; Nanhua Yao; John Pichardo; Thierry Fischmann; Corey Strickland; Joseph Myers; Patricia C Weber; Brian M Beyer; Richard Ingram; Zhi Hong; Winifred W Prosise; Lata Ramanathan; S Shane Taremi; Taisa Yarosh-Tomaine; Rumin Zhang; Mary Senior; Rong-Sheng Yang; Bruce Malcolm; Ashok Arasappan; Frank Bennett; Stephane L Bogen; Kevin Chen; Edwin Jao; Yi-Tsung Liu; Raymond G Lovey; Anil K Saksena; Srikanth Venkatraman; Viyyoor Girijavallabhan; F George Njoroge; Vincent Madison
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
Journal of medicinal chemistry 2007;50(10):2310-8.
2007: Rong Liu; Karim Abid; John Pichardo; Valerio Pazienza; Paul Ingravallo; Rong Kong; Sony Agrawal; Stéphane L Bogen; Anil K Saksena; Kuo-Chi Cheng; Andrew Prongay; F George Njoroge; Bahige M Baroudy; Francesco Negro
In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.
The Journal of antimicrobial chemotherapy 2007;59(1):51-8.
2006: Srikanth Venkatraman; Stéphane L Bogen; Ashok Arasappan; Frank Bennett; Kevin Chen; Edwin Jao; Yi-Tsung Liu; Raymond Lovey; Siska Hendrata; Yuhua Huang; Weidong Pan; Tejal Parekh; Patrick Pinto; Veljko Popov; Russel Pike; Sumei Ruan; Bama Santhanam; Bancha Vibulbhan; Wanli Wu; Weiying Yang; Jianshe Kong; Xiang Liang; Jesse Wong; Rong Liu; Nancy Butkiewicz; Robert Chase; Andrea Hart; Sony Agrawal; Paul Ingravallo; John Pichardo; Rong Kong; Bahige Baroudy; Bruce Malcolm; Zhuyan Guo; Andrew Prongay; Vincent Madison; Lisa Broske; Xiaoming Cui; Kuo-Chi Cheng; Yunsheng Hsieh; Jean-Marc Brisson; Danial Prelusky; Walter Korfmacher; Ronald White; Susan Bogdanowich-Knipp; Anastasia Pavlovsky; Prudence Bradley; Anil K Saksena; Ashit Ganguly; John Piwinski; Viyyoor Girijavallabhan; F George Njoroge
Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection.
Journal of medicinal chemistry 2006;49(20):6074-86.
2006: Ashok Arasappan; F George Njoroge; Kevin X Chen; Srikanth Venkatraman; Tejal N Parekh; Haining Gu; John Pichardo; Nancy Butkiewicz; Andrew Prongay; Vincent Madison; Viyyoor Girijavallabhan
P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease.
Bioorganic & medicinal chemistry letters 2006;16(15):3960-5.
2006: Stéphane L Bogen; Ashok Arasappan; Frank Bennett; Kevin Chen; Edwin Jao; Yi-Tsung Liu; Raymond G Lovey; Srikanth Venkatraman; Weidong Pan; Tejal N Parekh; Russel E Pike; Sumei Ruan; Rong Liu; Bahige M Baroudy; Sony Agrawal; Robert Chase; Paul Ingravallo; John Pichardo; Andrew Prongay; Jean-Marc Brisson; Tony Y Hsieh; Kuo-Chi Cheng; Scott J Kemp; Odile E Levy; Marguerita Lim-Wilby; Susan Y Tamura; Anil K Saksena; Viyyoor Girijavallabhan; F George Njoroge
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
Journal of medicinal chemistry 2006;49(9):2750-7.
2006: Srikanth Venkatraman; F George Njoroge; Wanli Wu; Viyyoor Girijavallabhan; Andrew Prongay; Nancy Butkiewicz; John Pichardo
Novel inhibitors of hepatitis C NS3-NS4A serine protease derived from 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid.
Bioorganic & medicinal chemistry letters 2006;16(6):1628-32.
2006: Stéphane L Bogen; Sumei Ruan; Rong Liu; Sony Agrawal; John Pichardo; Andrew Prongay; Bahige M Baroudy; Anil K Saksena; Viyyoor Girijavallabhan; F George Njoroge
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
Bioorganic & medicinal chemistry letters 2006;16(6):1621-7.
2006: Bruce A Malcolm; Rong Liu; Frederick C Lahser; Sony Agrawal; B Belanger; Nancy Butkiewicz; Robert Chase; Ferdous Gheyas; A Hart; David Hesk; Paul Ingravallo; C Jiang; R Kong; J Lu; John Pichardo; Andrew Prongay; Angela Skelton; Xiao Tong; Srikanth Venkatraman; Ellen Xia; Viyyoor Girijavallabhan; F George Njoroge
SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells.
Antimicrobial agents and chemotherapy 2006;50(3):1013-20.
2006: Kevin X Chen; F George Njoroge; Ashok Arasappan; Srikanth Venkatraman; Bancha Vibulbhan; Weiying Yang; Tejal N Parekh; John Pichardo; Andrew Prongay; Kuo-Chi Cheng; Nancy Butkiewicz; Nanhua Yao; Vincent Madison; Viyyoor Girijavallabhan
Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
Journal of medicinal chemistry 2006;49(3):995-1005.
2006: Kevin X Chen; F George Njoroge; John Pichardo; Andrew Prongay; Nancy Butkiewicz; Nanhua Yao; Vincent Madison; Viyyoor Girijavallabhan
Potent 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid-based macrocyclic inhibitors of hepatitis C virus NS3 protease.
Journal of medicinal chemistry 2006;49(2):567-74.
2005: Kevin X Chen; F George Njoroge; Bancha Vibulbhan; Andrew Prongay; John Pichardo; Vincent Madison; Alexei V Buevich; Tze-Ming Chan
Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
Angewandte Chemie (International ed. in English) 2005;44(43):7024-8.
2005: Stéphane L Bogen; Anil K Saksena; Ashok Arasappan; H Gu; F George Njoroge; Viyyoor Girijavallabhan; John Pichardo; Nancy Butkiewicz; Andrew Prongay; Vincent Madison
Hepatitis C virus NS3-4A serine protease inhibitors: use of a P2-P1 cyclopropyl alanine combination for improved potency.
Bioorganic & medicinal chemistry letters 2005;15(20):4515-9.
2005: Kevin X Chen; F George Njoroge; Andrew Prongay; John Pichardo; Vincent Madison; Viyyoor Girijavallabhan
Synthesis and biological activity of macrocyclic inhibitors of hepatitis C virus (HCV) NS3 protease.
Bioorganic & medicinal chemistry letters 2005;15(20):4475-8.
2005: Kevin X Chen; F George Njoroge; John Pichardo; Andrew Prongay; Nancy Butkiewicz; Nanhua Yao; Vincent Madison; Viyyoor Girijavallabhan
Design, synthesis, and biological activity of m-tyrosine-based 16- and 17-membered macrocyclic inhibitors of hepatitis C virus NS3 serine protease.
Journal of medicinal chemistry 2005;48(20):6229-35.
2005: Frank Bennett; Yi-Tsung Liu; Anil K Saksena; Ashok Arasappan; Nancy Butkiewicz; Bimalendu Dasmahapatra; John Pichardo; F George Njoroge; Naginbhai M Patel; Yuhua Huang; Xiaozheng Yang
Novel inhibitors of the hepatitis C virus NS3 proteinase.
Bioorganic & medicinal chemistry letters 2005;15(19):4275-8.
2005: A Arasappan; F G Njoroge; T-Y Chan; F Bennett; S L Bogen; K Chen; H Gu; L Hong; E Jao; Y-T Liu; R G Lovey; T Parekh; R E Pike; P Pinto; B Santhanam; S Venkatraman; H Vaccaro; H Wang; X Yang; Z Zhu; B Mckittrick; A K Saksena; V Girijavallabhan; John Pichardo; N Butkiewicz; R Ingram; B Malcolm; Andrew Prongay; N Yao; B Marten; V Madison; S Kemp; O Levy; M Lim-Wilby; S Tamura; A K Ganguly
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.
Bioorganic & medicinal chemistry letters 2005;15(19):4180-4.
2005: Srikanth Venkatraman; F George Njoroge; Viyyoor Girijavallabhan; Vincent Madison; Nanua H Yao; Andrew Prongay; Nancy Butkiewicz; John Pichardo
Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.
Journal of medicinal chemistry 2005;48(16):5088-91.
2004: Ashok Arasappan; F George Njoroge; Tejal N Parekh; Xiaozheng Yang; John Pichardo; Nancy Butkiewicz; Andrew Prongay; Nanhua Yao; Viyyoor Girijavallabhan
Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex.
Bioorganic & medicinal chemistry letters 2004;14(23):5751-5.
1999: Min Chu; Ronald Mierzwa; Ling He; A King; Mahesh Patel; John Pichardo; A Hart; Nancy Butkiewicz; Mohindar S Puar
Isolation and structure of SCH 351633: a novel hepatitis C virus (HCV) NS3 protease inhibitor from the fungus Penicillium griseofulvum.
Bioorganic & medicinal chemistry letters 1999;9(14):1949-52.
1996: Nancy Butkiewicz; M Wendel; Rumin Zhang; Ronald Jubin; John Pichardo; E B Smith; A M Hart; Richard N Ingram; James Durkin; P W Mui; MG Murray; Lata Ramanathan; B Dasmahapatra
Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity.
Virology 1996;225(2):328-38.