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Klaus Aktories

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
64
Just, Ingo
30
Barth, Holger
27
Schmidt, Gudula
20
Hofmann, Franz
12
Jank, Thomas
12
Selzer, J
10
Orth, Joachim
10
Giesemann, Torsten
10
Wilde, Christian
9
Busch, Christian
9
Meyer, Dieter
9
Schirmer, Jörg
8
Sehr, Peter
7
Vogelsgesang, Martin
7
Schulz, Georg

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Publications

TOP 3
Schwan Carsten; Stecher Bärbel; Tzivelekidis Tina; van Ham Marco; Rohde Manfred; Hardt Wolf-Dietrich; Wehland Jürgen; Aktories Klaus
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.
Belyi Yury; Stahl Michael; Sovkova Irina; Kaden Peter; Luy Burkhard; Aktories Klaus
Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.
Knust Zeynep; Blumenthal Britta; Aktories Klaus; Schmidt Gudula
Cleavage of Escherichia coli cytotoxic necrotizing factor 1 is required for full biologic activity.

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All Publications

2009: Schwan Carsten; Stecher Bärbel; Tzivelekidis Tina; van Ham Marco; Rohde Manfred; Hardt Wolf-Dietrich; Wehland Jürgen; Aktories Klaus
Clostridium difficile toxin CDT induces formation of microtubule-based protrusions and increases adherence of bacteria.
PLoS pathogens 2009;5(10):e1000626.
2009: Belyi Yury; Stahl Michael; Sovkova Irina; Kaden Peter; Luy Burkhard; Aktories Klaus
Region of elongation factor 1A1 involved in substrate recognition by Legionella pneumophila glucosyltransferase Lgt1: identification of Lgt1 as a retaining glucosyltransferase.
The Journal of biological chemistry 2009;284(30):20167-74.
2009: Knust Zeynep; Blumenthal Britta; Aktories Klaus; Schmidt Gudula
Cleavage of Escherichia coli cytotoxic necrotizing factor 1 is required for full biologic activity.
Infection and immunity 2009;77(5):1835-41.
2009: Orth Joachim H C; Preuss Inga; Fester Ines; Schlosser Andreas; Wilson Brenda A; Aktories Klaus
Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7179-84.
2009: Preuss Inga; Kurig Barbara; Nürnberg Bernd; Orth Joachim H C; Aktories Klaus
Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins.
Cellular signalling 2009;21(4):551-8.
2009: Egerer Martina; Giesemann Torsten; Herrmann Christian; Aktories Klaus
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate.
The Journal of biological chemistry 2009;284(6):3389-95.
2008: Lang Alexander E; Neumeyer Tobias; Sun Jianjun; Collier R John; Benz Roland; Aktories Klaus
Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin.
Biochemistry 2008;47(32):8406-13.
2008: Treiber Nora; Reinert Dirk J; Carpusca Irina; Aktories Klaus; Schulz Georg E
Structure and mode of action of a mosquitocidal holotoxin.
Journal of molecular biology 2008;381(1):150-9.
2008: Orth Joachim H C; Fester Ines; Preuss Inga; Agnoletto Laura; Wilson Brenda A; Aktories Klaus
Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin.
The Journal of biological chemistry 2008;283(34):23288-94.
2008: Büch Thomas R H; Biebermann Heike; Kalwa Hermann; Pinkenburg Olaf; Hager Denise; Barth Holger; Aktories Klaus; Breit Andreas; Gudermann Thomas
G13-dependent activation of MAPK by thyrotropin.
The Journal of biological chemistry 2008;283(29):20330-41.
2008: Jank Thomas; Ziegler Mathias O P; Schulz Georg E; Aktories Klaus
Inhibition of the glucosyltransferase activity of clostridial Rho/Ras-glucosylating toxins by castanospermine.
FEBS letters 2008;582(15):2277-82.
2008: Giesemann Torsten; Egerer Martina; Jank Thomas; Aktories Klaus
Processing of Clostridium difficile toxins.
Journal of medical microbiology 2008;57(Pt 6):690-6.
2008: Giesemann Torsten; Guttenberg Gregor; Aktories Klaus
Human alpha-defensins inhibit Clostridium difficile toxin B.
Gastroenterology 2008;134(7):2049-58.
2008: Jank Thomas; Aktories Klaus
Structure and mode of action of clostridial glucosylating toxins: the ABCD model.
Trends in microbiology 2008;16(5):222-9.
2008: Ziegler Mathias O P; Jank Thomas; Aktories Klaus; Schulz Georg E
Conformational changes and reaction of clostridial glycosylating toxins.
Journal of molecular biology 2008;377(5):1346-56.
2008: Vogelsgesang Martin; Stieglitz Benjamin; Herrmann Christian; Pautsch Alex; Aktories Klaus
Crystal structure of the Clostridium limosum C3 exoenzyme.
FEBS letters 2008;582(7):1032-6.
2008: Belyi Yury; Tabakova Irina; Stahl Michael; Aktories Klaus
Lgt: a family of cytotoxic glucosyltransferases produced by Legionella pneumophila.
Journal of bacteriology 2008;190(8):3026-35.
2008: Sun Jianjun; Lang Alexander E; Aktories Klaus; Collier R John
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(11):4346-51.
2008: Hennig Britta; Orth Joachim; Aktories Klaus; Diener Martin
Anion secretion evoked by Pasteurella multocida toxin across rat colon.
European journal of pharmacology 2008;583(1):156-63.
2008: Neumeyer Tobias; Schiffler Bettina; Maier Elke; Lang Alexander E; Aktories Klaus; Benz Roland
Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel.
The Journal of biological chemistry 2008;283(7):3904-14.
2007: Jank Thomas; Giesemann Torsten; Aktories Klaus
Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding.
The Journal of biological chemistry 2007;282(48):35222-31.
2007: Orth Joachim H C; Lang Simona; Preuss Inga; Milligan Graeme; Aktories Klaus
Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors.
Cellular signalling 2007;19(10):2174-82.
2007: Egerer Martina; Giesemann Torsten; Jank Thomas; Satchell Karla J Fullner; Aktories Klaus
Auto-catalytic cleavage of Clostridium difficile toxins A and B depends on cysteine protease activity.
The Journal of biological chemistry 2007;282(35):25314-21.
2007: Blumenthal Britta; Hoffmann Claudia; Aktories Klaus; Backert Steffen; Schmidt Gudula
The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol.
Infection and immunity 2007;75(7):3344-53.
2007: Aktories Klaus
Self-cutting to kill: new insights into the processing of Clostridium difficile toxins.
ACS chemical biology 2007;2(4):228-30.
2007: Hoffmann Claudia; Aktories Klaus; Schmidt Gudula
Change in substrate specificity of cytotoxic necrotizing factor unmasks proteasome-independent down-regulation of constitutively active RhoA.
The Journal of biological chemistry 2007;282(14):10826-32.
2007: Pust Sascha; Hochmann Henrike; Kaiser Eva; von Figura Guido; Heine Karin; Aktories Klaus; Barth Holger
A cell-permeable fusion toxin as a tool to study the consequences of actin-ADP-ribosylation caused by the salmonella enterica virulence factor SpvB in intact cells.
The Journal of biological chemistry 2007;282(14):10272-82.
2007: Jank Thomas; Giesemann Torsten; Aktories Klaus
Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function.
Glycobiology 2007;17(4):15R-22R.
2007: Orth Joachim H C; Aktories Klaus; Kubatzky Katharina F
Modulation of host cell gene expression through activation of STAT transcription factors by Pasteurella multocida toxin.
The Journal of biological chemistry 2007;282(5):3050-7.
2007: Vogelsgesang Martin; Pautsch Alexander; Aktories Klaus
C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins.
Naunyn-Schmiedeberg's archives of pharmacology 2007;374(5-6):347-60.
2006: Majumder Shubhra; Schmidt Gudula; Lohia Anuradha; Aktories Klaus
EhRho1, a RhoA-like GTPase of Entamoeba histolytica, is modified by clostridial glucosylating cytotoxins.
Applied and environmental microbiology 2006;72(12):7842-8.
2006: Schleberger Christian; Hochmann Henrike; Barth Holger; Aktories Klaus; Schulz Georg E
Structure and action of the binary C2 toxin from Clostridium botulinum.
Journal of molecular biology 2006;364(4):705-15.
2006: Carpusca Irina; Jank Thomas; Aktories Klaus
Bacillus sphaericus mosquitocidal toxin (MTX) and pierisin: the enigmatic offspring from the family of ADP-ribosyltransferases.
Molecular microbiology 2006;62(3):621-30.
2006: Kaiser Eva; Haug Gerd; Hliscs Marion; Aktories Klaus; Barth Holger
Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction.
Biochemistry 2006;45(44):13361-8.
2006: Belyi Yury; Niggeweg Ricarda; Opitz Bastian; Vogelsgesang Martin; Hippenstiel Stefan; Wilm Matthias; Aktories Klaus
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16953-8.
2006: Lessmann Eva; Grochowy Gordon; Weingarten Lars; Giesemann Torsten; Aktories Klaus; Leitges Michael; Krystal Gerald; Huber Michael
Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway.
Experimental hematology 2006;34(11):1532-41.
2006: Jank Thomas; Pack Ulrike; Giesemann Torsten; Schmidt Gudula; Aktories Klaus
Exchange of a single amino acid switches the substrate properties of RhoA and RhoD toward glucosylating and transglutaminating toxins.
The Journal of biological chemistry 2006;281(28):19527-35.
2006: Molinari Gabriella; Rohde Manfred; Wilde Christian; Just Ingo; Aktories Klaus; Chhatwal Gursharan S
Localization of the C3-Like ADP-ribosyltransferase from Staphylococcus aureus during bacterial invasion of mammalian cells.
Infection and immunity 2006;74(6):3673-7.
2006: Loucks F Alexandra; Le Shoshona S; Zimmermann Angela K; Ryan Kristen R; Barth Holger; Aktories Klaus; Linseman Daniel A
Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival.
Journal of neurochemistry 2006;97(4):957-67.
2006: Giesemann Torsten; Jank Thomas; Gerhard Ralf; Maier Elke; Just Ingo; Benz Roland; Aktories Klaus
Cholesterol-dependent pore formation of Clostridium difficile toxin A.
The Journal of biological chemistry 2006;281(16):10808-15.
2006: Reinert Dirk J; Carpusca Irina; Aktories Klaus; Schulz Georg E
Structure of the mosquitocidal toxin from Bacillus sphaericus.
Journal of molecular biology 2006;357(4):1226-36.
2006: Fueller Florian; Bergo Martin O; Young Stephen G; Aktories Klaus; Schmidt Gudula
Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.
Infection and immunity 2006;74(3):1712-7.
2006: Blöcker Dagmar; Berod Luciana; Fluhr Joachim W; Orth Joachim; Idzko Marco; Aktories Klaus; Norgauer Johannes
Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis.
International immunology 2006;18(3):459-64.
2006: Hochmann Henrike; Pust Sascha; von Figura Guido; Aktories Klaus; Barth Holger
Salmonella enterica SpvB ADP-ribosylates actin at position arginine-177-characterization of the catalytic domain within the SpvB protein and a comparison to binary clostridial actin-ADP-ribosylating toxins.
Biochemistry 2006;45(4):1271-7.
2006: Vogelsgesang Martin; Aktories Klaus
Exchange of glutamine-217 to glutamate of Clostridium limosum exoenzyme C3 turns the asparagine-specific ADP-ribosyltransferase into an arginine-modifying enzyme.
Biochemistry 2006;45(3):1017-25.
2006: Haug Gerd; Barth Holger; Aktories Klaus
Purification and activity of the Rho ADP-ribosylating binary C2/C3 toxin.
Methods in enzymology 2006;406():117-27.
2005: Fortemaison Nathalie; Blancquaert Sara; Dumont Jacques E; Maenhaut Carine; Aktories Klaus; Roger Pierre P; Dremier Sarah
Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis.
Endocrinology 2005;146(12):5485-95.
2005: Jank Thomas; Reinert Dirk J; Giesemann Torsten; Schulz Georg E; Aktories Klaus
Change of the donor substrate specificity of Clostridium difficile toxin B by site-directed mutagenesis.
The Journal of biological chemistry 2005;280(45):37833-8.
2005: Orth Joachim H C; Lang Simona; Taniguchi Masatoshi; Aktories Klaus
Pasteurella multocida toxin-induced activation of RhoA is mediated via two families of G{alpha} proteins, G{alpha}q and G{alpha}12/13.
The Journal of biological chemistry 2005;280(44):36701-7.
2005: Pautsch Alexander; Vogelsgesang Martin; Tränkle Jens; Herrmann Christian; Aktories Klaus
Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme.
The EMBO journal 2005;24(20):3670-80.
2005: Reinert Dirk J; Jank Thomas; Aktories Klaus; Schulz Georg E
Structural basis for the function of Clostridium difficile toxin B.
Journal of molecular biology 2005;351(5):973-81.
2005: Le Shoshona S; Loucks F Alexandra; Udo Hiroshi; Richardson-Burns Sarah; Phelps Reid A; Bouchard Ron J; Barth Holger; Aktories Klaus; Tyler Kenneth L; Kandel Eric R; Heidenreich Kim A; Linseman Daniel A
Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.
Journal of neurochemistry 2005;94(4):1025-39.
2005: Aktories Klaus; Barbieri Joseph T
Bacterial cytotoxins: targeting eukaryotic switches.
Nature reviews. Microbiology 2005;3(5):397-410.
2005: Aktories K; Just I
Clostridial Rho-inhibiting protein toxins.
Current topics in microbiology and immunology 2005;291():113-45.
2004: Averbeck Marco; Braun Thorsten; Pfeifer Gunther; Sleeman Jonathan; Dudda Jan; Martin Stefan F; Kremer Bernhard; Aktories Klaus; Simon Jan C; Termeer Christian
Early cytoskeletal rearrangement during dendritic cell maturation enhances synapse formation and Ca(2+) signaling in CD8(+) T cells.
European journal of immunology 2004;34(10):2708-19.
2004: Carpusca Irina; Schirmer Jörg; Aktories Klaus
Two-site autoinhibition of the ADP-ribosylating mosquitocidal toxin (MTX) from Bacillus sphaericus by its 70-kDa ricin-like binding domain.
Biochemistry 2004;43(38):12009-19.
2004: Barth Holger; Aktories Klaus; Popoff Michel R; Stiles Bradley G
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins.
Microbiology and molecular biology reviews : MMBR 2004;68(3):373-402, table of contents.
2004: Orth Joachim H C; Lang Simona; Aktories Klaus
Action of Pasteurella multocida toxin depends on the helical domain of Galphaq.
The Journal of biological chemistry 2004;279(33):34150-5.
2004: Pop Marius; Aktories Klaus; Schmidt Gudula
Isotype-specific degradation of Rac activated by the cytotoxic necrotizing factor 1.
The Journal of biological chemistry 2004;279(34):35840-8.
2004: Schirmer Jörg; Aktories Klaus
Large clostridial cytotoxins: cellular biology of Rho/Ras-glucosylating toxins.
Biochimica et biophysica acta 2004;1673(1-2):66-74.
2004: Haug Gerd; Aktories Klaus; Barth Holger
The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins.
Infection and immunity 2004;72(5):3066-8.
2004: Aktories Klaus; Barth Holger
The actin-ADP-ribosylating Clostridium botulinum C2 toxin.
Anaerobe 2004;10(2):101-5.
2004: Aktories Klaus; Barth Holger
Clostridium botulinum C2 toxin--new insights into the cellular up-take of the actin-ADP-ribosylating toxin.
International journal of medical microbiology : IJMM 2004;293(7-8):557-64.
2004: Hoffmann Claudia; Pop Marius; Leemhuis Jost; Schirmer Jörg; Aktories Klaus; Schmidt Gudula
The Yersinia pseudotuberculosis cytotoxic necrotizing factor (CNFY) selectively activates RhoA.
The Journal of biological chemistry 2004;279(16):16026-32.
2004: Leemhuis Jost; Boutillier Stephanie; Barth Holger; Feuerstein Thomas J; Brock Carsten; Nürnberg Bernd; Aktories Klaus; Meyer Dieter K
Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites.
The Journal of biological chemistry 2004;279(1):585-96.
2004: Aktories K; Wilde C; Vogelsgesang M
Rho-modifying C3-like ADP-ribosyltransferases.
Reviews of physiology, biochemistry and pharmacology 2004;152():1-22.
2003: Haug Gerd; Wilde Christian; Leemhuis Jost; Meyer Dieter K; Aktories Klaus; Barth Holger
Cellular uptake of Clostridium botulinum C2 toxin: membrane translocation of a fusion toxin requires unfolding of its dihydrofolate reductase domain.
Biochemistry 2003;42(51):15284-91.
2003: Pfeifer Gunther; Schirmer Jörg; Leemhuis Jost; Busch Christian; Meyer Dieter K; Aktories Klaus; Barth Holger
Cellular uptake of Clostridium difficile toxin B. Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells.
The Journal of biological chemistry 2003;278(45):44535-41.
2003: Bachmeyer Christoph; Orlik Frank; Barth Holger; Aktories Klaus; Benz Roland
Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis.
Journal of molecular biology 2003;333(3):527-40.
2003: Geyer Matthias; Wilde Christian; Selzer Jörg; Aktories Klaus; Kalbitzer Hans Robert
Glucosylation of Ras by Clostridium sordellii lethal toxin: consequences for effector loop conformations observed by NMR spectroscopy.
Biochemistry 2003;42(41):11951-9.
2003: Blöcker Dagmar; Pohlmann Kathrin; Haug Gerd; Bachmeyer Christoph; Benz Roland; Aktories Klaus; Barth Holger
Clostridium botulinum C2 toxin: low pH-induced pore formation is required for translocation of the enzyme component C2I into the cytosol of host cells.
The Journal of biological chemistry 2003;278(39):37360-7.
2003: Wilde Christian; Vogelsgesang Martin; Aktories Klaus
Rho-specific Bacillus cereus ADP-ribosyltransferase C3cer cloning and characterization.
Biochemistry 2003;42(32):9694-702.
2003: Sorg Isabel; Hoffmann Claudia; Dumbach Juergen; Aktories Klaus; Schmidt Gudula
The C terminus of YopT is crucial for activity and the N terminus is crucial for substrate binding.
Infection and immunity 2003;71(8):4623-32.
2003: Haug Gerd; Leemhuis Jost; Tiemann Dirk; Meyer Dieter K; Aktories Klaus; Barth Holger
The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol.
The Journal of biological chemistry 2003;278(34):32266-74.
2003: Genth Harald; Gerhard Ralf; Maeda Akio; Amano Mutsuki; Kaibuchi Kozo; Aktories Klaus; Just Ingo
Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex.
The Journal of biological chemistry 2003;278(31):28523-7.
2003: Gerhard Ralf; John Harald; Aktories Klaus; Just Ingo
Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases.
Molecular pharmacology 2003;63(6):1349-55.
2003: Blöcker Dagmar; Bachmeyer Christoph; Benz Roland; Aktories Klaus; Barth Holger
Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo.
Biochemistry 2003;42(18):5368-77.
2003: Orth Joachim H C; Blöcker Dagmar; Aktories Klaus
His1205 and His1223 are essential for the activity of the mitogenic Pasteurella multocida toxin.
Biochemistry 2003;42(17):4971-7.
2003: Aktories Klaus; Schmidt Gudula
A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors.
Trends in microbiology 2003;11(4):152-5.
2003: Djouder Nabil; Aneiros Eduardo; Cavalié Adolfo; Aktories Klaus
Effects of large clostridial cytotoxins on activation of RBL 2H3-hm1 mast cells indicate common and different roles of Rac in FcepsilonRI and M1-receptor signaling.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1243-50.
2003: Genth Harald; Schmidt Martina; Gerhard Ralf; Aktories Klaus; Just Ingo
Activation of phospholipase D1 by ADP-ribosylated RhoA.
Biochemical and biophysical research communications 2003;302(1):127-32.
2003: Srinivasan Supriya; Wang Fei; Glavas Suzana; Ott Alexander; Hofmann Fred; Aktories Klaus; Kalman Daniel; Bourne Henry R
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis.
The Journal of cell biology 2003;160(3):375-85.
2003: Frisch Cornelia; Gerhard Ralf; Aktories Klaus; Hofmann Fred; Just Ingo
The complete receptor-binding domain of Clostridium difficile toxin A is required for endocytosis.
Biochemical and biophysical research communications 2003;300(3):706-11.
2002: Barth Holger; Blöcker Dagmar; Aktories Klaus
The uptake machinery of clostridial actin ADP-ribosylating toxins--a cell delivery system for fusion proteins and polypeptide drugs.
Naunyn-Schmiedeberg's archives of pharmacology 2002;366(6):501-12.
2002: Schirmer Jörg; Wieden Hans-Joachim; Rodnina Marina V; Aktories Klaus
Inactivation of the elongation factor Tu by mosquitocidal toxin-catalyzed mono-ADP-ribosylation.
Applied and environmental microbiology 2002;68(10):4894-9.
2002: Lerm Maria; Pop Marius; Fritz Gerhard; Aktories Klaus; Schmidt Gudula
Proteasomal degradation of cytotoxic necrotizing factor 1-activated rac.
Infection and immunity 2002;70(8):4053-8.
2002: Carton Iris; Trouet Dominique; Hermans Diane; Barth Holger; Aktories Klaus; Droogmans Guy; Jorgensen Nanna K; Hoffmann Else K; Nilius Bernd; Eggermont Jan
RhoA exerts a permissive effect on volume-regulated anion channels in vascular endothelial cells.
American journal of physiology. Cell physiology 2002;283(1):C115-25.
2002: Kerkhoff Eugen; Leberfinger Cornelia B; Schmidt Gudula; Aktories Klaus; Rapp Ulf R
Diverse effects of RacV12 on cell transformation by Raf: partial inhibition of morphological transformation versus deregulation of cell cycle control.
Biochimica et biophysica acta 2002;1589(2):151-9.
2002: Wilde Christian; Barth Holger; Sehr Peter; Han Li; Schmidt Martina; Just Ingo; Aktories Klaus
Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA.
The Journal of biological chemistry 2002;277(17):14771-6.
2002: Li Xiaodong; Saint-Cyr-Proulx Etienne; Aktories Klaus; Lamarche-Vane Nathalie
Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells.
The Journal of biological chemistry 2002;277(17):15207-14.
2002: Riese Matthew J; Goehring Udo-Michael; Ehrmantraut Mary E; Moss Joel; Barbieri Joseph T; Aktories Klaus; Schmidt Gudula
Auto-ADP-ribosylation of Pseudomonas aeruginosa ExoS.
The Journal of biological chemistry 2002;277(14):12082-8.
2002: Schirmer Jörg; Just Ingo; Aktories Klaus
The ADP-ribosylating mosquitocidal toxin from Bacillus sphaericus: proteolytic activation, enzyme activity, and cytotoxic effects.
The Journal of biological chemistry 2002;277(14):11941-8.
2002: Wilde Christian; Just Ingo; Aktories Klaus
Structure-function analysis of the Rho-ADP-ribosylating exoenzyme C3stau2 from Staphylococcus aureus.
Biochemistry 2002;41(5):1539-44.
2002: Barth Holger; Roebling Robert; Fritz Michaela; Aktories Klaus
The binary Clostridium botulinum C2 toxin as a protein delivery system: identification of the minimal protein region necessary for interaction of toxin components.
The Journal of biological chemistry 2002;277(7):5074-81.
2002: Wilde Christian; Chhatwal Gursharan S; Aktories Klaus
C3stau, a new member of the family of C3-like ADP-ribosyltransferases.
Trends in microbiology 2002;10(1):5-7.
2002: Barbieri Joseph T; Riese Matthew J; Aktories Klaus
Bacterial toxins that modify the actin cytoskeleton.
Annual review of cell and developmental biology 2002;18():315-44.
2001: Schmidt G; Goehring U M; Schirmer J; Uttenweiler-Joseph S; Wilm M; Lohmann M; Giese A; Schmalzing G; Aktories K
Lysine and polyamines are substrates for transglutamination of Rho by the Bordetella dermonecrotic toxin.
Infection and immunity 2001;69(12):7663-70.
2001: Sorg I; Goehring U M; Aktories K; Schmidt G
Recombinant Yersinia YopT leads to uncoupling of RhoA-effector interaction.
Infection and immunity 2001;69(12):7535-43.
2001: Wilde C; Aktories K
The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases.
Toxicon : official journal of the International Society on Toxinology 2001;39(11):1647-60.
2001: Gülke I; Pfeifer G; Liese J; Fritz M; Hofmann F; Aktories K; Barth H
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Infection and immunity 2001;69(10):6004-11.
2001: Bachmeyer C; Benz R; Barth H; Aktories K; Gilbert M; Popoff M R
Interaction of Clostridium botulinum C2 toxin with lipid bilayer membranes and Vero cells: inhibition of channel function by chloroquine and related compounds in vitro and intoxification in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(9):1658-60.
2001: Busch C; Orth J; Djouder N; Aktories K
Biological activity of a C-terminal fragment of Pasteurella multocida toxin.
Infection and immunity 2001;69(6):3628-34.
2001: Blöcker D; Behlke J; Aktories K; Barth H
Cellular uptake of the Clostridium perfringens binary iota-toxin.
Infection and immunity 2001;69(5):2980-7.
2001: Barth H; Pfeifer G; Hofmann F; Maier E; Benz R; Aktories K
Low pH-induced formation of ion channels by clostridium difficile toxin B in target cells.
The Journal of biological chemistry 2001;276(14):10670-6.
2001: Wilde C; Chhatwal G S; Schmalzing G; Aktories K; Just I
A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.
The Journal of biological chemistry 2001;276(12):9537-42.
2001: Djouder N; Schmidt G; Frings M; Cavalié A; Thelen M; Aktories K
Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1627-34.
2000: Busch C; Schömig K; Hofmann F; Aktories K
Characterization of the catalytic domain of Clostridium novyi alpha-toxin.
Infection and immunity 2000;68(11):6378-83.
2000: Busch C; Aktories K
Microbial toxins and the glycosylation of rho family GTPases.
Current opinion in structural biology 2000;10(5):528-35.
2000: Krall R; Schmidt G; Aktories K; Barbieri J T
Pseudomonas aeruginosa ExoT is a Rho GTPase-activating protein.
Infection and immunity 2000;68(10):6066-8.
2000: Meyer D K; Olenik C; Hofmann F; Barth H; Leemhuis J; Brünig I; Aktories K; Nörenberg W
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6743-51.
2000: Lerm M; Schmidt G; Aktories K
Bacterial protein toxins targeting rho GTPases.
FEMS microbiology letters 2000;188(1):1-6.
2000: Djouder N; Prepens U; Aktories K; Cavalie A
Inhibition of calcium release-activated calcium current by Rac/Cdc42-inactivating clostridial cytotoxins in RBL cells.
The Journal of biological chemistry 2000;275(25):18732-8.
2000: Barth H; Blocker D; Behlke J; Bergsma-Schutter W; Brisson A; Benz R; Aktories K
Cellular uptake of Clostridium botulinum C2 toxin requires oligomerization and acidification.
The Journal of biological chemistry 2000;275(25):18704-11.
2000: Wilde C; Genth H; Aktories K; Just I
Recognition of RhoA by Clostridium botulinum C3 exoenzyme.
The Journal of biological chemistry 2000;275(22):16478-83.
2000: Busch C; Hofmann F; Gerhard R; Aktories K
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.
The Journal of biological chemistry 2000;275(18):13228-34.
2000: Genth H; Selzer J; Busch C; Dumbach J; Hofmann F; Aktories K; Just I
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infection and immunity 2000;68(3):1094-101.
2000: Eckhardt M; Barth H; Blöcker D; Aktories K
Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates.
The Journal of biological chemistry 2000;275(4):2328-34.
2000: Schmidt G; Aktories K
Rho GTPase-activating toxins: cytotoxic necrotizing factors and dermonecrotic toxin.
Methods in enzymology 2000;325():125-36.
2000: Just I; Hofmann F; Aktories K
Molecular mode of action of the large clostridial cytotoxins.
Current topics in microbiology and immunology 2000;250():55-83.
1999: Goehring U M; Schmidt G; Pederson K J; Aktories K; Barbieri J T
The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases.
The Journal of biological chemistry 1999;274(51):36369-72.
1999: Schmidt G; Goehring U M; Schirmer J; Lerm M; Aktories K
Identification of the C-terminal part of Bordetella dermonecrotic toxin as a transglutaminase for rho GTPases.
The Journal of biological chemistry 1999;274(45):31875-81.
1999: Genth H; Aktories K; Just I
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling.
The Journal of biological chemistry 1999;274(41):29050-6.
1999: Lerm M; Schmidt G; Goehring U M; Schirmer J; Aktories K
Identification of the region of rho involved in substrate recognition by Escherichia coli cytotoxic necrotizing factor 1 (CNF1).
The Journal of biological chemistry 1999;274(41):28999-9004.
1999: Barth H; Klingler M; Aktories K; Kinzel V
Clostridium botulinum C2 toxin delays entry into mitosis and activation of p34cdc2 kinase and cdc25-C phosphatase in HeLa cells.
Infection and immunity 1999;67(10):5083-90.
1999: Barth H; Olenik C; Sehr P; Schmidt G; Aktories K; Meyer D K
Neosynthesis and activation of Rho by Escherichia coli cytotoxic necrotizing factor (CNF1) reverse cytopathic effects of ADP-ribosylated Rho.
The Journal of biological chemistry 1999;274(39):27407-14.
1999: Nörenberg W; Hofmann F; Illes P; Aktories K; Meyer D K
Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA.
British journal of pharmacology 1999;127(5):1060-3.
1999: Olenik C; Aktories K; Meyer D K
Differential expression of the small GTP-binding proteins RhoA, RhoB, Cdc42u and Cdc42b in developing rat neocortex.
Brain research. Molecular brain research 1999;70(1):9-17.
1999: Pederson K J; Vallis A J; Aktories K; Frank D W; Barbieri J T
The amino-terminal domain of Pseudomonas aeruginosa ExoS disrupts actin filaments via small-molecular-weight GTP-binding proteins.
Molecular microbiology 1999;32(2):393-401.
1999: Nilius B; Voets T; Prenen J; Barth H; Aktories K; Kaibuchi K; Droogmans G; Eggermont J
Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells.
The Journal of physiology 1999;516 ( Pt 1)():67-74.
1999: Lerm M; Selzer J; Hoffmeyer A; Rapp U R; Aktories K; Schmidt G
Deamidation of Cdc42 and Rac by Escherichia coli cytotoxic necrotizing factor 1: activation of c-Jun N-terminal kinase in HeLa cells.
Infection and immunity 1999;67(2):496-503.
1998: Barth H; Preiss J C; Hofmann F; Aktories K
Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis.
The Journal of biological chemistry 1998;273(45):29506-11.
1998: Gerhard R; Schmidt G; Hofmann F; Aktories K
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.
Infection and immunity 1998;66(11):5125-31.
1998: Busch C; Hofmann F; Selzer J; Munro S; Jeckel D; Aktories K
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
The Journal of biological chemistry 1998;273(31):19566-72.
1998: Schmidt G; Aktories K
Bacterial cytotoxins target Rho GTPases.
Die Naturwissenschaften 1998;85(6):253-61.
1998: Schmidt G; Selzer J; Lerm M; Aktories K
The Rho-deamidating cytotoxic necrotizing factor 1 from Escherichia coli possesses transglutaminase activity. Cysteine 866 and histidine 881 are essential for enzyme activity.
The Journal of biological chemistry 1998;273(22):13669-74.
1998: Sehr P; Joseph G; Genth H; Just I; Pick E; Aktories K
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.
Biochemistry 1998;37(15):5296-304.
1998: Barth H; Hofmann F; Olenik C; Just I; Aktories K
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin.
Infection and immunity 1998;66(4):1364-9.
1998: Prepens U; Barth H; Wilting J; Aktories K
Influence of Clostridium botulinum C2 toxin on Fc epsilonRI-mediated secretion and tyrosine phosphorylation in RBL cells.
Naunyn-Schmiedeberg's archives of pharmacology 1998;357(3):323-30.
1998: Hofmann F; Busch C; Aktories K
Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition.
Infection and immunity 1998;66(3):1076-81.
1997: Olenik C; Barth H; Just I; Aktories K; Meyer D K
Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain.
Brain research. Molecular brain research 1997;52(2):263-9.
1997: Koch G; Benz C; Schmidt G; Olenik C; Aktories K
Role of Rho protein in lovastatin-induced breakdown of actin cytoskeleton.
The Journal of pharmacology and experimental therapeutics 1997;283(2):901-9.
1997: Aktories K
Rho proteins: targets for bacterial toxins.
Trends in microbiology 1997;5(7):282-8.
1997: Schmidt G; Sehr P; Wilm M; Selzer J; Mann M; Aktories K
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.
Nature 1997;387(6634):725-9.
1997: Hofmann F; Busch C; Prepens U; Just I; Aktories K
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of the holotoxin.
The Journal of biological chemistry 1997;272(17):11074-8.
1997: Wex C B; Koch G; Aktories K
Effects of Clostridium difficile toxin B on activation of rat peritoneal mast cells.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(3):328-34.
1997: Wex C B; Koch G; Aktories K
Effects of Clostridium botulinum C2 toxin-induced depolymerisation of actin on degranulation of suspended and attached mast cells.
Naunyn-Schmiedeberg's archives of pharmacology 1997;355(3):319-27.
1997: Aktories K
Bacterial toxins that target Rho proteins.
The Journal of clinical investigation 1997;99(5):827-9.
1997: Prepens U; Just I; Hofmann F; Aktories K
ADP-ribosylating and glucosylating toxins as tools to study secretion in RBL cells.
Advances in experimental medicine and biology 1997;419():349-53.
1997: Aktories K
Identification of the catalytic site of clostridial ADP-ribosyltransferases.
Advances in experimental medicine and biology 1997;419():53-60.
1996: Sehr P; Just I; Aktories K
ADP-ribosylation of actin by Clostridium perfringens iota toxin and turkey erythrocyte ADP-ribosyltransferase A: effects on profilin-regulated nucleotide exchange and ATPase activity.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(6):693-7.
1996: Genth H; Hofmann F; Selzer J; Rex G; Aktories K; Just I
Difference in protein substrate specificity between hemorrhagic toxin and lethal toxin from Clostridium sordellii.
Biochemical and biophysical research communications 1996;229(2):370-4.
1996: Hofmann F; Rex G; Aktories K; Just I
The ras-related protein Ral is monoglucosylated by Clostridium sordellii lethal toxin.
Biochemical and biophysical research communications 1996;227(1):77-81.
1996: Selzer J; Hofmann F; Rex G; Wilm M; Mann M; Just I; Aktories K
Clostridium novyi alpha-toxin-catalyzed incorporation of GlcNAc into Rho subfamily proteins.
The Journal of biological chemistry 1996;271(41):25173-7.
1996: Geipel U; Just I; Aktories K
ADP-ribosylation of an approximately 70-kilodalton protein of Klebsiella pneumoniae.
Infection and immunity 1996;64(5):1720-3.
1996: Just I; Selzer J; Hofmann F; Green G A; Aktories K
Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation.
The Journal of biological chemistry 1996;271(17):10149-53.
1996: Prepens U; Just I; von Eichel-Streiber C; Aktories K
Inhibition of Fc epsilon-RI-mediated activation of rat basophilic leukemia cells by Clostridium difficile toxin B (monoglucosyltransferase)
The Journal of biological chemistry 1996;271(13):7324-9.
1996: Kiefer G; Lerner M; Sehr P; Just I; Aktories K
Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin.
Medical microbiology and immunology 1996;184(4):175-80.
1996: Ermert L; Rössig R; Hansen T; Schütte H; Aktories K; Seeger W
Differential role of actin in lung endothelial and epithelial barrier properties in perfused rabbit lungs.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(1):93-9.
1996: Böhmer J; Jung M; Sehr P; Fritz G; Popoff M; Just I; Aktories K
Active site mutation of the C3-like ADP-ribosyltransferase from Clostridium limosum--analysis of glutamic acid 174.
Biochemistry 1996;35(1):282-9.
1995: Fritz G; Kaina B; Aktories K
The ras-related small GTP-binding protein RhoB is immediate-early inducible by DNA damaging treatments.
The Journal of biological chemistry 1995;270(42):25172-7.
1995: Just I; Selzer J; Wilm M; von Eichel-Streiber C; Mann M; Aktories K
Glucosylation of Rho proteins by Clostridium difficile toxin B.
Nature 1995;375(6531):500-3.
1995: Just I; Wilm M; Selzer J; Rex G; von Eichel-Streiber C; Mann M; Aktories K
The enterotoxin from Clostridium difficile (ToxA) monoglucosylates the Rho proteins.
The Journal of biological chemistry 1995;270(23):13932-6.
1995: Fritz G; Schroeder P; Aktories K
Isolation and characterization of a Clostridium botulinum C2 toxin-resistant cell line: evidence for possible involvement of the cellular C2II receptor in growth regulation.
Infection and immunity 1995;63(6):2334-40.
1995: Ermert L; Brückner H; Walmrath D; Grimminger F; Aktories K; Suttorp N; Duncker H R; Seeger W
Role of endothelial cytoskeleton in high-permeability edema due to botulinum C2 toxin in perfused rabbit lungs.
The American journal of physiology 1995;268(5 Pt 1):L753-61.
1995: Just I; Selzer J; von Eichel-Streiber C; Aktories K
The low molecular mass GTP-binding protein Rho is affected by toxin A from Clostridium difficile.
The Journal of clinical investigation 1995;95(3):1026-31.
1995: Just I; Selzer J; Jung M; van Damme J; Vandekerckhove J; Aktories K
Rho-ADP-ribosylating exoenzyme from Bacillus cereus. Purification, characterization, and identification of the NAD-binding site.
Biochemistry 1995;34(1):334-40.
1995: Just I; Sehr P; Jung M; van Damme J; Puype M; Vandekerckhove J; Moss J; Aktories K
ADP-ribosyltransferase type A from turkey erythrocytes modifies actin at Arg-95 and Arg-372.
Biochemistry 1995;34(1):326-33.
1995: Aktories K; Jung M; Böhmer J; Fritz G; Vandekerckhove J; Just I
Studies on the active-site structure of C3-like exoenzymes: involvement of glutamic acid in catalysis of ADP-ribosylation.
Biochimie 1995;77(5):326-32.
1995: Aktories K; Just I
In vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases.
Methods in enzymology 1995;256():184-95.
1994: Aktories K
Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins.
Molecular and cellular biochemistry 1994;138(1-2):167-76.
1994: Fritz G; Just I; Wollenberg P; Aktories K
Differentiation-induced increase in Clostridium botulinum C3 exoenzyme-catalyzed ADP-ribosylation of the small GTP-binding protein Rho.
European journal of biochemistry / FEBS 1994;223(3):909-16.
1994: Just I; Richter H P; Prepens U; von Eichel-Streiber C; Aktories K
Probing the action of Clostridium difficile toxin B in Xenopus laevis oocytes.
Journal of cell science 1994;107 ( Pt 6)():1653-9.
1994: Fritz G; Aktories K
ADP-ribosylation of Rho proteins by Clostridium botulinum exoenzyme C3 is influenced by phosphorylation of Rho-associated factors.
The Biochemical journal 1994;300 ( Pt 1)():133-9.
1994: Koch G; Norgauer J; Aktories K
ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells.
The Biochemical journal 1994;299 ( Pt 3)():775-9.
1994: Just I; Wollenberg P; Moss J; Aktories K
Cysteine-specific ADP-ribosylation of actin.
European journal of biochemistry / FEBS 1994;221(3):1047-54.
1994: Just I; Fritz G; Aktories K; Giry M; Popoff M R; Boquet P; Hegenbarth S; von Eichel-Streiber C
Clostridium difficile toxin B acts on the GTP-binding protein Rho.
The Journal of biological chemistry 1994;269(14):10706-12.
1994: Schroeder P; Just I; Aktories K
Adenine nucleotides regulate ADP-ribosylation of membrane-bound actin and actin-binding to membranes.
European journal of cell biology 1994;63(1):3-9.
1994: Wegner A; Aktories K; Ditsch A; Just I; Schoepper B; Selve N; Wille M
Actin-gelsolin interaction.
Advances in experimental medicine and biology 1994;358():97-104.
1993: Jung M; Just I; van Damme J; Vandekerckhove J; Aktories K
NAD-binding site of the C3-like ADP-ribosyltransferase from Clostridium limosum.
The Journal of biological chemistry 1993;268(31):23215-8.
1993: Hinsch K D; Habermann B; Just I; Hinsch E; Pfisterer S; Schill W B; Aktories K
ADP-ribosylation of Rho proteins inhibits sperm motility.
FEBS letters 1993;334(1):32-6.
1993: Just I; Wille M; Chaponnier C; Aktories K
Gelsolin-actin complex is target for ADP-ribosylation by Clostridium botulinum C2 toxin in intact human neutrophils.
European journal of pharmacology 1993;246(3):293-7.
1993: Just I; Hennessey E S; Drummond D R; Aktories K; Sparrow J C
ADP-ribosylation of Drosophila indirect-flight-muscle actin and arthrin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
The Biochemical journal 1993;291 ( Pt 2)():409-12.
1993: Just I; Mohr C; Habermann B; Koch G; Aktories K
Enhancement of Clostridium botulinum C3-catalysed ADP-ribosylation of recombinant rhoA by sodium dodecyl sulfate.
Biochemical pharmacology 1993;45(7):1409-16.
1992: Aktories K; Wegner A
Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins.
Molecular microbiology 1992;6(20):2905-8.
1992: Koch G; Mohr C; Just I; Aktories K
Posttranslational isoprenylation of rho protein is a prerequisite for its interaction with mastoparan and other amphiphilic agents.
Biochemical and biophysical research communications 1992;186(1):448-54.
1992: Just I; Mohr C; Schallehn G; Menard L; Didsbury J R; Vandekerckhove J; van Damme J; Aktories K
Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum.
The Journal of biological chemistry 1992;267(15):10274-80.
1992: Koch G; Habermann B; Mohr C; Just I; Aktories K
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80.
European journal of pharmacology 1992;226(1):87-91.
1992: Just I; Schallehn G; Aktories K
ADP-ribosylation of small GTP-binding proteins by Bacillus cereus.
Biochemical and biophysical research communications 1992;183(3):931-6.
1992: Norgauer J; Eberle M; Lemke H D; Aktories K
Activation of human neutrophils by mastoparan. Reorganization of the cytoskeleton, formation of phosphatidylinositol 3,4,5-trisphosphate, secretion up-regulation of complement receptor type 3 and superoxide anion production are stimulated by mastoparan.
The Biochemical journal 1992;282 ( Pt 2)():393-7.
1992: Mohr C; Koch G; Just I; Aktories K
ADP-ribosylation by Clostridium botulinum C3 exoenzyme increases steady-state GTPase activities of recombinant rhoA and rhoB proteins.
FEBS letters 1992;297(1-2):95-9.
1992: Wille M; Just I; Wegner A; Aktories K
ADP-ribosylation of gelsolin-actin complexes by clostridial toxins.
The Journal of biological chemistry 1992;267(1):50-5.
1992: Aktories K; Wille M; Just I
Clostridial actin-ADP-ribosylating toxins.
Current topics in microbiology and immunology 1992;175():97-113.
1992: Aktories K; Mohr C; Koch G
Clostridium botulinum C3 ADP-ribosyltransferase.
Current topics in microbiology and immunology 1992;175():115-31.
1991: Koch G; Haberman B; Mohr C; Just I; Aktories K
Interaction of mastoparan with the low molecular mass GTP-binding proteins rho/rac.
FEBS letters 1991;291(2):336-40.
1991: Grimminger F; Sibelius U; Aktories K; Suttorp N; Seeger W
Inhibition of cytoskeletal rearrangement by botulinum C2 toxin amplifies ligand-evoked lipid mediator generation in human neutrophils.
Molecular pharmacology 1991;40(4):563-71.
1991: Grimminger F; Sibelius U; Aktories K; Just I; Seeger W
Suppression of cytoskeletal rearrangement in activated human neutrophils by botulinum C2 toxin. Impact on cellular signal transduction.
The Journal of biological chemistry 1991;266(29):19276-82.
1991: Suttorp N; Polley M; Seybold J; Schnittler H; Seeger W; Grimminger F; Aktories K
Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro.
The Journal of clinical investigation 1991;87(5):1575-84.
1991: Habermann B; Mohr C; Just I; Aktories K
ADP-ribosylation and de-ADP-ribosylation of the rho protein by Clostridium botulinum exoenzyme C3. Regulation by EDTA, guanine nucleotides and pH.
Biochimica et biophysica acta 1991;1077(3):253-8.
1990: Just I; Geipel U; Wegner A; Aktories K
De-ADP-ribosylation actin by Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin.
European journal of biochemistry / FEBS 1990;192(3):723-7.
1990: Geipel U; Just I; Aktories K
Inhibition of cytochalasin D-stimulated G-actin ATPase by ADP-ribosylation with Clostridium perfringens iota toxin.
The Biochemical journal 1990;266(2):335-9.
1990: Aktories K
Clostridial ADP-ribosyltransferases--modification of low molecular weight GTP-binding proteins and of actin by clostridial toxins.
Medical microbiology and immunology 1990;179(3):123-36.
1990: Aktories K; Geipel U; Wille M; Just I
Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.
Journal de physiologie 1990;84(4):262-6.
1989: Aktories K; Wegner A
ADP-ribosylation of actin by clostridial toxins.
The Journal of cell biology 1989;109(4 Pt 1):1385-7.
1989: Mauss S; Koch G; Kreye V A; Aktories K
Inhibition of the contraction of the isolated longitudinal muscle of the guinea-pig ileum by botulinum C2 toxin: evidence for a role of G/F-actin transition in smooth muscle contraction.
Naunyn-Schmiedeberg's archives of pharmacology 1989;340(3):345-51.
1989: Weigt C; Just I; Wegner A; Aktories K
Nonmuscle actin ADP-ribosylated by botulinum C2 toxin caps actin filaments.
FEBS letters 1989;246(1-2):181-4.
1989: Matter K; Dreyer F; Aktories K
Actin involvement in exocytosis from PC12 cells: studies on the influence of botulinum C2 toxin on stimulated noradrenaline release.
Journal of neurochemistry 1989;52(2):370-6.
1989: Geipel U; Just I; Schering B; Haas D; Aktories K
ADP-ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis.
European journal of biochemistry / FEBS 1989;179(1):229-32.
1989: Braun U; Habermann B; Just I; Aktories K; Vandekerckhove J
Purification of the 22 kDa protein substrate of botulinum ADP-ribosyltransferase C3 from porcine brain cytosol and its characterization as a GTP-binding protein highly homologous to the rho gene product.
FEBS letters 1989;243(1):70-6.
1989: Aktories K; Reuner K H; Presek P; Bärmann M
Botulinum C2 toxin treatment increases the G-actin pool in intact chicken cells: a model for the cytopathic action of actin-ADP-ribosylating toxins.
Toxicon : official journal of the International Society on Toxinology 1989;27(9):989-93.
1988: Aktories K; Just I; Rosenthal W
Different types of ADP-ribose protein bonds formed by botulinum C2 toxin, botulinum ADP-ribosyltransferase C3 and pertussis toxin.
Biochemical and biophysical research communications 1988;156(1):361-7.
1988: Norgauer J; Kownatzki E; Seifert R; Aktories K
Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils.
The Journal of clinical investigation 1988;82(4):1376-82.
1988: Wegner A; Aktories K
ADP-ribosylated actin caps the barbed ends of actin filaments.
The Journal of biological chemistry 1988;263(27):13739-42.
1988: Willuweit B; Aktories K
Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes.
Naunyn-Schmiedeberg's archives of pharmacology 1988;337(3):354-8.
1988: Vandekerckhove J; Schering B; Bärmann M; Aktories K
Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.
The Journal of biological chemistry 1988;263(2):696-700.
1988: Schering B; Bärmann M; Chhatwal G S; Geipel U; Aktories K
ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin.
European journal of biochemistry / FEBS 1988;171(1-2):225-9.
1987: Vandekerckhove J; Schering B; Bärmann M; Aktories K
Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.
FEBS letters 1987;225(1-2):48-52.
1987: Rösener S; Chhatwal G S; Aktories K
Botulinum ADP-ribosyltransferase C3 but not botulinum neurotoxins C1 and D ADP-ribosylates low molecular mass GTP-binding proteins.
FEBS letters 1987;224(1):38-42.
1987: Aktories K; Frevert J
ADP-ribosylation of a 21-24 kDa eukaryotic protein(s) by C3, a novel botulinum ADP-ribosyltransferase, is regulated by guanine nucleotide.
The Biochemical journal 1987;247(2):363-8.

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