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Alan Lehmann

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Sharada Ramasubramanyan; Stephane Coulon; Robert P Fuchs; Alan Lehmann; Catherine Green
Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe.
Pierre-Olivier Mari; Vincent Verbiest; Simone Sabbioneda; Audrey M Gourdin; Nils Wijgers; Christoffel Dinant; Alan Lehmann; Wim Vermeulen; Giuseppina Giglia-Mari
Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes.
Stephanie Brown; Atsuko Niimi; Alan Lehmann
Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.

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All Publications

2010: Sharada Ramasubramanyan; Stephane Coulon; Robert P Fuchs; Alan Lehmann; Catherine Green
Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe.
DNA repair 2010;9(7):777-84.
2010: Pierre-Olivier Mari; Vincent Verbiest; Simone Sabbioneda; Audrey M Gourdin; Nils Wijgers; Christoffel Dinant; Alan Lehmann; Wim Vermeulen; Giuseppina Giglia-Mari
Influence of the live cell DNA marker DRAQ5 on chromatin-associated processes.
DNA repair 2010;9(7):848-55.
2009: Stephanie Brown; Atsuko Niimi; Alan Lehmann
Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.
Cell cycle (Georgetown, Tex.) 2009;8(5):689-92.
2009: Simone Sabbioneda; Catherine Green; Marzena Bienko; Patricia Kannouche; Ivan Dikic; Alan Lehmann
Ubiquitin-binding motif of human DNA polymerase eta is required for correct localization.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):E20; author reply E21.
2008: Simone Sabbioneda; Audrey Gourdin; Catherine Green; Angelika Zotter; Giuseppina Giglia-Mari; Adriaan Houtsmuller; Wim Vermeulen; Alan Lehmann
Effect of proliferating cell nuclear antigen ubiquitination and chromatin structure on the dynamic properties of the Y-family DNA polymerases.
Molecular biology of the cell 2008;19(12):5193-202.
2008: Alan Lehmann
XPD structure reveals its secrets.
DNA repair 2008;7(11):1912-5.
2008: Atsuko Niimi; Stephanie Brown; Simone Sabbioneda; Patricia Kannouche; Andrew Scott; Akira Yasui; Catherine Green; Alan Lehmann
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16125-30.
2008: Anu Anttinen; Leena Koulu; Eeva Nikoskelainen; Raija Portin; Timo Kurki; Matti Erkinjuntti; Nicolaas G J Jaspers; Anja Raams; Michael H L Green; Alan Lehmann; Jonathan F Wing; Colin F Arlett; Reijo J Marttila
Neurological symptoms and natural course of xeroderma pigmentosum.
Brain : a journal of neurology 2008;131(Pt 8):1979-89.
2008: Wim J Kleijer; Vincent Laugel; Mark Berneburg; Tiziana Nardo; Heather Fawcett; Alexei Gratchev; Nicolaas G J Jaspers; Alain Sarasin; Miria Stefanini; Alan Lehmann
Incidence of DNA repair deficiency disorders in western Europe: Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
DNA repair 2008;7(5):744-50.
2008: EM Taylor; Alice C Copsey; JJ Hudson; Susanne Vidot; Alan Lehmann
Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.
Molecular and cellular biology 2008;28(4):1197-206.
2008: Colin F Arlett; Michael H L Green; PB Rogers; Alan Lehmann; PN Plowman
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
The British journal of radiology 2008;81(961):51-8.
2007: Alan Lehmann; Atsuko Niimi; Tomoo Ogi; Stephanie Brown; Simone Sabbioneda; Jonathan F Wing; Patricia Kannouche; Catherine Green
Translesion synthesis: Y-family polymerases and the polymerase switch.
DNA repair 2007;6(7):891-9.
2007: Elena Botta; Judith Offman; Tiziana Nardo; Roberta Ricotti; Giovanna Zambruno; Daniela Sansone; Paolo Balestri; Anja Raams; Wim J Kleijer; Nicolaas G J Jaspers; Alain Sarasin; Alan Lehmann; Miria Stefanini
Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.
Human mutation 2007;28(1):92-6.
2006: Alan Lehmann; Robert Fuchs
Gaps and forks in DNA replication: Rediscovering old models.
DNA repair 2006;5(12):1495-8.
2006: Jan Palecek; Susanne Vidot; Min Feng; Aidan J Doherty; Alan Lehmann
The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits.
The Journal of biological chemistry 2006;281(48):36952-9.
2006: Alan Lehmann
New functions for Y family polymerases.
Molecular cell 2006;24(4):493-5.
2006: Alan Lehmann
Translesion synthesis in mammalian cells.
Experimental cell research 2006;312(14):2673-6.
2006: Errol C Friedberg; Andres Aguilera; Martin Gellert; Philip C Hanawalt; John B Hays; Alan Lehmann; Tomas Lindahl; Noel Lowndes; Alain Sarasin; Richard D Wood
DNA repair: from molecular mechanism to human disease.
DNA repair 2006;5(8):986-96.
2006: Jaan-Olle Andressoo; James R Mitchell; Jan de Wit; Deborah Hoogstraten; Marcel Volker; Wendy Toussaint; Ewoud Speksnijder; Rudolf B Beems; Harry van Steeg; Judith Jans; Chris I De Zeeuw; Nicolaas G J Jaspers; Anja Raams; Alan Lehmann; Wim Vermeulen; Jan H J Hoeijmakers; Gijsbertus T J van der Horst
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.
Cancer cell 2006;10(2):121-32.
2006: Rachel U Sidwell; A Sandison; Jonathan F Wing; Heather Fawcett; JE Seet; C Fisher; Tiziana Nardo; Miria Stefanini; Alan Lehmann; J J Cream
A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma.
The British journal of dermatology 2006;155(1):81-8.
2006: Jonathan Frampton; Anja Irmisch; Catherine Green; Andrea Neiss; Michelle Trickey; Helle D Ulrich; Kanji Furuya; Felicity Z Watts; Antony M Carr; Alan Lehmann
Postreplication repair and PCNA modification in Schizosaccharomyces pombe.
Molecular biology of the cell 2006;17(7):2976-85.
2006: Tomoo Ogi; Alan Lehmann
The Y-family DNA polymerase kappa (pol kappa) functions in mammalian nucleotide-excision repair.
Nature cell biology 2006;8(6):640-2.
2006: Colin F Arlett; PN Plowman; PB Rogers; C N Parris; F Abbaszadeh; Michael H L Green; T J McMillan; C Bush; Nicolas Foray; Alan Lehmann
Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum.
The British journal of radiology 2006;79(942):510-7.
2006: Alan Lehmann
Clubbing together on clamps: The key to translesion synthesis.
DNA repair 2006;5(3):404-7.
2005: Marzena Bienko; Catherine Green; Nicola Crosetto; Fabian Rudolf; Grzegorz Zapart; Barry Coull; Patricia Kannouche; Gerhard Wider; Matthias Peter; Alan Lehmann; Kay Hofmann; Ivan Dikic
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science (New York, N.Y.) 2005;310(5755):1821-4.
2005: Mark Albertella; Catherine Green; Alan Lehmann; Mark J O'Connor
A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.
Cancer research 2005;65(21):9799-806.
2005: Therina Theron; Maria Fousteri; Marcel Volker; Lorna W Harries; Elena Botta; Miria Stefanini; Mitsuo Fujimoto; Jaan-Olle Andressoo; Jay Mitchell; Nicolaas G J Jaspers; Lisa D McDaniel; Leon H F Mullenders; Alan Lehmann
Transcription-associated breaks in xeroderma pigmentosum group D cells from patients with combined features of xeroderma pigmentosum and Cockayne syndrome.
Molecular and cellular biology 2005;25(18):8368-78.
2005: Mitsuo Fujimoto; Suzanne N Leech; Therina Theron; Masato Mori; Heather Fawcett; Elena Botta; Yasuyuki Nozaki; Takanori Yamagata; Shigeru Moriwaki; Miria Stefanini; Mariko Y Momoi; Hidemi Nakagawa; Sam Shuster; Celia Moss; Alan Lehmann
Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features.
The Journal of investigative dermatology 2005;125(1):86-92.
2005: Errol C Friedberg; Alan Lehmann; Robert Fuchs
Trading places: how do DNA polymerases switch during translesion DNA synthesis?
Molecular cell 2005;18(5):499-505.
2005: Alan Lehmann
The role of SMC proteins in the responses to DNA damage.
DNA repair 2005;4(3):309-14.
2005: Alan Lehmann
Replication of damaged DNA by translesion synthesis in human cells.
FEBS letters 2005;579(4):873-6.
2005: Catherine Green; Alan Lehmann
Translesion synthesis and error-prone polymerases.
Advances in experimental medicine and biology 2005;570():199-223.
2005: Emily A Andrews; Jan Palecek; John Sergeant; Elaine Taylor; Alan Lehmann; Felicity Z Watts
Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage.
Molecular and cellular biology 2005;25(1):185-96.
2005: John Sergeant; Elaine Taylor; Jan Palecek; Maria Fousteri; Emily A Andrews; Sara Sweeney; Hideo Shinagawa; Felicity Z Watts; Alan Lehmann
Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.
Molecular and cellular biology 2005;25(1):172-84.
2005: Tomoo Ogi; Patricia Kannouche; Alan Lehmann
Localisation of human Y-family DNA polymerase kappa: relationship to PCNA foci.
Journal of cell science 2005;118(Pt 1):129-36.
2004: Antonio E Vidal; Patricia Kannouche; Vladimir N Podust; WEI YANG; Alan Lehmann; Roger Woodgate
Proliferating cell nuclear antigen-dependent coordination of the biological functions of human DNA polymerase iota.
The Journal of biological chemistry 2004;279(46):48360-8.
2004: Agnes TISSIER; Patricia Kannouche; Marie-Pierre Reck; Alan Lehmann; Robert Fuchs; Agnès Cordonnier
Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.
DNA repair 2004;3(11):1503-14.
2004: Yosef Shiloh; Alan Lehmann
Maintaining integrity.
Nature cell biology 2004;6(10):923-8.
2004: Patricia Kannouche; Alan Lehmann
Ubiquitination of PCNA and the polymerase switch in human cells.
Cell cycle (Georgetown, Tex.) 2004;3(8):1011-3.
2004: Patricia Kannouche; Jonathan F Wing; Alan Lehmann
Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.
Molecular cell 2004;14(4):491-500.
2004: Alexandra Vaisman; Alan Lehmann; Roger Woodgate
DNA polymerases eta and iota.
Advances in protein chemistry 2004;69():205-28.
2003: Ewan R Taylor; Edward S Dornan; Winifred Boner; Julie A Connolly; Shona McNair; Patricia Kannouche; Alan Lehmann; Iain M Morgan
The fidelity of HPV16 E1/E2-mediated DNA replication.
The Journal of biological chemistry 2003;278(52):52223-30.
2003: Alan Lehmann
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
Biochimie 2003;85(11):1101-11.
2003: Alan Lehmann
Replication of damaged DNA.
Cell cycle (Georgetown, Tex.) 2003;2(4):300-2.
2003: Anne Stary; Patricia Kannouche; Alan Lehmann; Alain Sarasin
Role of DNA polymerase eta in the UV mutation spectrum in human cells.
The Journal of biological chemistry 2003;278(21):18767-75.
2003: Patricia Kannouche; Antonio R Fernández de Henestrosa; Barry Coull; Antonio E Vidal; Colin Gray; Daniel Zicha; Roger Woodgate; Alan Lehmann
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.
The EMBO journal 2003;22(5):1223-33.
2002: Alan Lehmann
Replication of damaged DNA in mammalian cells: new solutions to an old problem.
Mutation research 2002;509(1-2):23-34.
2002: Patricia Kannouche; Antonio R Fernández de Henestrosa; Barry Coull; Antonio E Vidal; Colin Gray; Daniel Zicha; Roger Woodgate; Alan Lehmann
Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.
The EMBO journal 2002;21(22):6246-56.
2002: Elena Botta; Tiziana Nardo; Alan Lehmann; Jean-Marc Egly; Antonia M Pedrini; Miria Stefanini
Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy.
Human molecular genetics 2002;11(23):2919-28.
2002: Bernard C Broughton; Agnes M Cordonnier; Wim J Kleijer; Nicolaas G J Jaspers; Heather Fawcett; Anja Raams; Victor H Garritsen; Anne Stary; Marie-Françoise Avril; François Boudsocq; Chikahide Masutani; Fumio Hanaoka; Robert Fuchs; Alain Sarasin; Alan Lehmann
Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):815-20.
2001: Vip Viprakasit; Richard J Gibbons; Bernard C Broughton; J L Tolmie; D Brown; P Lunt; Robin M Winter; S Marinoni; Miria Stefanini; Louise A Brueton; Alan Lehmann; Douglas R Higgs
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Human molecular genetics 2001;10(24):2797-802.
2001: Bernard C Broughton; Mark Berneburg; Heather Fawcett; EM Taylor; Colin F Arlett; Tiziana Nardo; Miria Stefanini; Emory Menefee; Vera H Price; S Queille; Alain Sarasin; E Bohnert; Jean Krutmann; R Davidson; Kenneth H Kraemer; Alan Lehmann
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Human molecular genetics 2001;10(22):2539-47.
2001: EM Taylor; J S Moghraby; J H Lees; B Smit; P B Moens; Alan Lehmann
Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex.
Molecular biology of the cell 2001;12(6):1583-94.
2001: Xianmin Zeng; David B Winter; Cynthia Kasmer; Kenneth H Kraemer; Alan Lehmann; Patricia J Gearhart
DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes.
Nature immunology 2001;2(6):537-41.
2001: Patricia Kannouche; Bernard C Broughton; Marcel Volker; F Hanaoka; Leon H F Mullenders; Alan Lehmann
Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.
Genes & development 2001;15(2):158-72.
2001: Alan Lehmann
The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases.
Genes & development 2001;15(1):15-23.
2001: Mark Berneburg; Alan Lehmann
Xeroderma pigmentosum and related disorders: defects in DNA repair and transcription.
Advances in genetics 2001;43():71-102.
2000: Alan Lehmann
Replication of UV-damaged DNA: new insights into links between DNA polymerases, mutagenesis and human disease.
Gene 2000;253(1):1-12.
2000: S Colella; Tiziana Nardo; Elena Botta; Alan Lehmann; Miria Stefanini
Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-cacchione variant of xeroderma pigmentosum.
Human molecular genetics 2000;9(8):1171-5.
2000: Annelies de Klein; Manja Muijtjens; RI van Os; Y Verhoeven; B Smit; A M Carr; Alan Lehmann; Jan H J Hoeijmakers
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.
Current biology : CB 2000;10(8):479-82.
2000: Maria Fousteri; Alan Lehmann
A novel SMC protein complex in Schizosaccharomyces pombe contains the Rad18 DNA repair protein.
The EMBO journal 2000;19(7):1691-702.
2000: F Chavanne; Bernard C Broughton; Daniela Pietra; Tiziana Nardo; A Browitt; Alan Lehmann; Miria Stefanini
Mutations in the XPC gene in families with xeroderma pigmentosum and consequences at the cell, protein, and transcript levels.
Cancer research 2000;60(7):1974-82.
2000: Mark Berneburg; Jillian E Lowe; Tiziana Nardo; S Araújo; Maria Fousteri; Michael H L Green; Jean Krutmann; Richard D Wood; Miria Stefanini; Alan Lehmann
UV damage causes uncontrolled DNA breakage in cells from patients with combined features of XP-D and Cockayne syndrome.
The EMBO journal 2000;19(5):1157-66.
2000: Mark Berneburg; Peter H Clingen; SA Harcourt; Jillian E Lowe; EM Taylor; Michael H L Green; Jean Krutmann; Colin F Arlett; Alan Lehmann
The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect.
Cancer research 2000;60(2):431-8.
2000: Carolino Monteiro; L A Marcelino; Ana R Conde; C Saraiva; Micheline Giphart-Gassler; AG de Nooij-van Dalen; Vera van Buuren-van Seggelen; Maarten van der Keur; C A May; J Cole; Alan Lehmann; H Steinsgrimsdottir; DM Beare; E Capulas; J A Armour
Molecular methods for the detection of mutations.
Teratogenesis, carcinogenesis, and mutagenesis 2000;20(6):357-86.
1999: John P McDonald; V Rapić-Otrin; Jonathan A Epstein; Bernard C Broughton; X Wang; Alan Lehmann; D J Wolgemuth; Roger Woodgate
Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.
Genomics 1999;60(1):20-30.
1999: Anneke Van Hoffen; W H Kalle; A de Jong-Versteeg; Alan Lehmann; Albert A van Zeeland; Leon H F Mullenders
Cells from XP-D and XP-D-CS patients exhibit equally inefficient repair of UV-induced damage in transcribed genes but different capacity to recover UV-inhibited transcription.
Nucleic acids research 1999;27(14):2898-904.
1999: Enriqueta Riballo; S E Critchlow; S H Teo; Aidan J Doherty; A Priestley; Bernard C Broughton; Boris Kysela; Heather Beamish; N Plowman; Colin F Arlett; Alan Lehmann; Stephen P Jackson; Penny A Jeggo
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.
Current biology : CB 1999;9(13):699-702.
1999: S Colella; Tiziana Nardo; D Mallery; C Borrone; R Ricci; G Ruffa; Alan Lehmann; Miria Stefanini
Alterations in the CSB gene in three Italian patients with the severe form of Cockayne syndrome (CS) but without clinical photosensitivity.
Human molecular genetics 1999;8(5):935-41.
1999: Agnes M Cordonnier; Alan Lehmann; Robert Fuchs
Impaired translesion synthesis in xeroderma pigmentosum variant extracts.
Molecular and cellular biology 1999;19(3):2206-11.
1998: Elena Botta; Tiziana Nardo; Bernard C Broughton; S Marinoni; Alan Lehmann; Miria Stefanini
Analysis of mutations in the XPD gene in Italian patients with trichothiodystrophy: site of mutation correlates with repair deficiency, but gene dosage appears to determine clinical severity.
American journal of human genetics 1998;63(4):1036-48.
1998: EM Taylor; Alan Lehmann
Conservation of eukaryotic DNA repair mechanisms.
International journal of radiation biology 1998;74(3):277-86.
1998: Penny A Jeggo; A M Carr; Alan Lehmann
Splitting the ATM: distinct repair and checkpoint defects in ataxia-telangiectasia.
Trends in genetics : TIG 1998;14(8):312-6.
1998: Jan de Boer; Jan de Wit; Harry van Steeg; Rob J W Berg; Hans Morreau; P Visser; Alan Lehmann; M Duran; Jan H J Hoeijmakers; Geert Weeda
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
Molecular cell 1998;1(7):981-90.
1998: Maria Svetlova; Lioudmila Solovjeva; Andrey Nikiforov; V A Chagin; Alan Lehmann; Nikolai Tomilin
Staurosporine-sensitive protein phosphorylation is required for postreplication DNA repair in human cells.
FEBS letters 1998;428(1-2):23-6.
1998: Alan Lehmann
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
BioEssays : news and reviews in molecular, cellular and developmental biology 1998;20(2):146-55.
1998: D L Mallery; B Tanganelli; S Colella; H Steingrimsdottir; Alain van Gool; C Troelstra; Miria Stefanini; Alan Lehmann
Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome.
American journal of human genetics 1998;62(1):77-85.
1997: EM Taylor; Bernard C Broughton; Elena Botta; Miria Stefanini; Alain Sarasin; Nicolaas G J Jaspers; Heather Fawcett; SA Harcourt; Colin F Arlett; Alan Lehmann
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8658-63.
1997: C Ahrens; Markus Grewe; Mark Berneburg; Susanne Grether-Beck; X Quilliet; M Mezzina; Alain Sarasin; Alan Lehmann; Colin F Arlett; Jean Krutmann
Photocarcinogenesis and inhibition of intercellular adhesion molecule 1 expression in cells of DNA-repair-defective individuals.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):6837-41.
1997: R Yonemasu; SJ McCready; J M Murray; F Osman; M Takao; K Yamamoto; Alan Lehmann; A Yasui
Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe.
Nucleic acids research 1997;25(8):1553-8.
1997: BK Singleton; A Priestley; H Steingrimsdottir; D Gell; T Blunt; Stephen P Jackson; Alan Lehmann; Penny A Jeggo
Molecular and biochemical characterization of xrs mutants defective in Ku80.
Molecular and cellular biology 1997;17(3):1264-73.
1997: Lisa D McDaniel; R Legerski; Alan Lehmann; Errol C Friedberg; Roger A Schultz
Confirmation of homozygosity for a single nucleotide substitution mutation in a Cockayne syndrome patient using monoallelic mutation analysis in somatic cell hybrids.
Human mutation 1997;10(4):317-21.
1996: Alan Lehmann; B A Bridges; P C Hanawalt; robert johnson; R Kanaar; H E Krokan; Soterios A Kyrtopoulos; B Lambert; D W Melton; E Moustacchi; A T Natarajan; M Radman; A Sarasin; E Seeberg; M J Smerdon; C A Smith; P J Smith; J Thacker; J Thomale; R Waters; G Weeda; S C West; A A van Zeeland; M Z Zdzienicka
Workshop on processing of DNA damage.
Mutation research 1996;364(3):245-70.
1996: S Moriwaki; M Stefanini; Alan Lehmann; Jan H J Hoeijmakers; J H Robbins; Isabelle Rapin; Elena Botta; B Tanganelli; Wim Vermeulen; Bernard C Broughton; Kenneth H Kraemer
DNA repair and ultraviolet mutagenesis in cells from a new patient with xeroderma pigmentosum group G and cockayne syndrome resemble xeroderma pigmentosum cells.
The Journal of investigative dermatology 1996;107(4):647-53.
1996: T Blunt; D Gell; M Fox; Guillermo E Taccioli; Alan Lehmann; Stephen P Jackson; Penny A Jeggo
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10285-90.
1996: Alan Lehmann
Molecular biology of DNA repair in the fission yeast Schizosaccharomyces pombe.
Mutation research 1996;363(3):147-61.
1996: H Steingrimsdottir; D Beare; J Cole; J F Leal; T Kostic; J Lopez-Barea; Gabriel Dorado; Alan Lehmann
Development of new molecular procedures for the detection of genetic alterations in man.
Mutation research 1996;353(1-2):109-21.
1996: M Stefanini; H Fawcett; Elena Botta; Tiziana Nardo; Alan Lehmann
Genetic analysis of twenty-two patients with Cockayne syndrome.
Human genetics 1996;97(4):418-23.
1996: Bernard C Broughton; H Steingrimsdottir; Alan Lehmann
Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene.
Mutation research 1996;362(2):209-11.
1996: K Takayama; Edmund P Salazar; Bernard C Broughton; Alan Lehmann; Alain Sarasin; Larry H Thompson; C A Weber
Defects in the DNA repair and transcription gene ERCC2(XPD) in trichothiodystrophy.
American journal of human genetics 1996;58(2):263-70.
1996: L V Solov'eva; Maria Svetlova; R Hancock; R Whittle; Alan Lehmann; D Bootsma; Nikolai Tomilin
[The dual function of the proliferating cell nuclear antigen (PCNA) in the response of human cells to UV damages].
Tsitologiia 1996;38(12):1294-302.
1995: D J Griffiths; N C Barbet; SJ McCready; Alan Lehmann; Antony M Carr
Fission yeast rad17: a homologue of budding yeast RAD24 that shares regions of sequence similarity with DNA polymerase accessory proteins.
The EMBO journal 1995;14(23):5812-23.
1995: Alan Lehmann; M Walicka; D J Griffiths; J M Murray; Felicity Z Watts; SJ McCready; Antony M Carr
The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair.
Molecular and cellular biology 1995;15(12):7067-80.
1995: Alan Lehmann
Nucleotide excision repair and the link with transcription.
Trends in biochemical sciences 1995;20(10):402-5.
1995: Alan Lehmann; A M Carr
The ataxia-telangiectasia gene: a link between checkpoint controls, neurodegeneration and cancer.
Trends in genetics : TIG 1995;11(10):375-7.
1995: S A Lynch; D de Berker; Alan Lehmann; Rodney J Pollitt; M M Reid; W H Lamb
Trichothiodystrophy with sideroblastic anaemia and developmental delay.
Archives of disease in childhood 1995;73(3):249-51.
1995: K A Henning; L Li; N Iyer; Lisa D McDaniel; M S Reagan; R Legerski; Roger A Schultz; M Stefanini; Alan Lehmann; L V Mayne; Errol C Friedberg
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
Cell 1995;82(4):555-64.
1995: H Steingrimsdottir; D Beare; Antony M Carr; J Cole; Alan Lehmann
U.v.-hypermutability of xeroderma pigmentosum cells demonstrated with a DNA-based mutation system.
Oncogene 1995;10(10):2057-66.
1995: Alan Lehmann
Workshop on eukaryotic DNA repair genes and gene products.
Cancer research 1995;55(4):968-70.
1995: KK Sanford; R Parshad; FM Price; Robert E Tarone; Alan Lehmann
G2 phase repair of X-ray-induced chromosomal DNA damage in trichothiodystrophy cells.
Mutation research 1995;346(2):107-14.
1995: Alan Lehmann
The molecular biology of nucleotide excision repair and double-strand break repair in eukaryotes.
Genetic engineering 1995;17():1-19.
1994: Penny Jeggo; Antony M Carr; Alan Lehmann
Cloning human DNA repair genes.
International journal of radiation biology 1994;66(5):573-7.
1994: Guillermo E Taccioli; Tanya Gottlieb; T Blunt; A Priestley; Jocelyne Demengeot; R Mizuta; Alan Lehmann; F W Alt; Stephen P Jackson; Penny A Jeggo
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination.
Science (New York, N.Y.) 1994;265(5177):1442-5.
1994: M Mezzina; Eric Eveno; O Chevallier-Lagente; A Benoit; M Carreau; Wim Vermeulen; Jan H J Hoeijmakers; M Stefanini; Alan Lehmann; C A Weber
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells.
Carcinogenesis 1994;15(8):1493-8.
1994: J M Murray; M Tavassoli; R al-Harithy; K S Sheldrick; Alan Lehmann; Antony M Carr; F Z Watts
Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.
Molecular and cellular biology 1994;14(7):4878-88.
1994: Alan Lehmann; D Bootsma; S G Clarkson; J E Cleaver; P J McAlpine; K Tanaka; L H Thompson; R D Wood
Nomenclature of human DNA repair genes.
Mutation research 1994;315(1):41-2.
1994: Bernard C Broughton; H Steingrimsdottir; C A Weber; Alan Lehmann
Mutations in the xeroderma pigmentosum group D DNA repair/transcription gene in patients with trichothiodystrophy.
Nature genetics 1994;7(2):189-94.
1994: Chiara Mondello; Tiziana Nardo; S Giliani; J E Arrand; C A Weber; Alan Lehmann; Fiorella Nuzzo; M Stefanini
Molecular analysis of the XP-D gene in Italian families with patients affected by trichothiodystrophy and xeroderma pigmentosum group D.
Mutation research 1994;314(2):159-65.
1994: F al-Khodairy; E Fotou; K S Sheldrick; D J Griffiths; Alan Lehmann; Antony M Carr
Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.
Molecular biology of the cell 1994;5(2):147-60.
1994: Alan Lehmann; Antony M Carr
DNA damage, repair and the cell cycle.
Trends in cell biology 1994;4(1):24-6.
1994: John Tolmie; D de Berker; R Dawber; C Galloway; D W Gregory; Alan Lehmann; J McClure; Rodney J Pollitt; John Stephenson
Syndromes associated with trichothiodystrophy.
Clinical dysmorphology 1994;3(1):1-14.
1994: Wim Vermeulen; A J van Vuuren; M Chipoulet; L Schaeffer; Esther Appeldoorn; Geert Weeda; Nicolaas G J Jaspers; A Priestley; C F Arlett; Alan Lehmann
Three unusual repair deficiencies associated with transcription factor BTF2(TFIIH): evidence for the existence of a transcription syndrome.
Cold Spring Harbor symposia on quantitative biology 1994;59():317-29.
1993: C L Doe; J M Murray; M Shayeghi; M Hoskins; Alan Lehmann; Antony M Carr; Felicity Z Watts
Cloning and characterisation of the Schizosaccharomyces pombe rad8 gene, a member of the SNF2 helicase family.
Nucleic acids research 1993;21(25):5964-71.
1993: Alan Lehmann
Duplicated region of sequence similarity to the human XRCC1 DNA repair gene in the Schizosaccharomyces pombe rad4/cut5 gene.
Nucleic acids research 1993;21(22):5274.
1993: SJ McCready; Antony M Carr; Alan Lehmann
Repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in the fission yeast Schizosaccharomyces pombe.
Molecular microbiology 1993;10(4):885-90.
1993: D F Muris; Kees Vreeken; Antony M Carr; Bernard C Broughton; Alan Lehmann; Paul H M Lohman; Albert Pastink
Cloning the RAD51 homologue of Schizosaccharomyces pombe.
Nucleic acids research 1993;21(19):4586-91.
1993: M Hafezparast; Pali Kaur; Malgorzata Z Zdzienicka; Raghbir S Athwal; Alan Lehmann; Penny A Jeggo
Subchromosomal localization of a gene (XRCC5) involved in double strand break repair to the region 2q34-36.
Somatic cell and molecular genetics 1993;19(5):413-21.
1993: Alan Lehmann; A F Thompson; S A Harcourt; M Stefanini; P G Norris
Cockayne's syndrome: correlation of clinical features with cellular sensitivity of RNA synthesis to UV irradiation.
Journal of medical genetics 1993;30(8):679-82.
1993: M Stefanini; P Lagomarsini; S Giliani; Tiziana Nardo; Elena Botta; A Peserico; W J Kleijer; Alan Lehmann; Alain Sarasin
Genetic heterogeneity of the excision repair defect associated with trichothiodystrophy.
Carcinogenesis 1993;14(6):1101-5.
1993: John Berth-Jones; J Cole; Alan Lehmann; C F Arlett; R A C Graham-Brown
Xeroderma pigmentosum variant: 5 years of tumour suppression by etretinate.
Journal of the Royal Society of Medicine 1993;86(6):355-6.
1993: H Steingrimsdottir; G Rowley; Alastair Waugh; D Beare; I Ceccherini; J Cole; Alan Lehmann
Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors.
Mutation research 1993;294(1):29-41.
1993: Antony M Carr; K S Sheldrick; J M Murray; R al-Harithy; F Z Watts; Alan Lehmann
Evolutionary conservation of excision repair in Schizosaccharomyces pombe: evidence for a family of sequences related to the Saccharomyces cerevisiae RAD2 gene.
Nucleic acids research 1993;21(6):1345-9.
1993: Tomas Lindahl; claude prigent; Deborah E Barnes; Alan Lehmann; M S Satoh; E Roberts; R A Nash; Peter Robins; Graham Daly
DNA joining in mammalian cells.
Cold Spring Harbor symposia on quantitative biology 1993;58():619-24.
1992: A M Carr; M H Green; Alan Lehmann
Checkpoint policing by p53.
Nature 1992;359(6395):486-7.
1992: A D Webster; D E Barnes; C F Arlett; Alan Lehmann; T Lindahl
Growth retardation and immunodeficiency in a patient with mutations in the DNA ligase I gene.
Lancet 1992;339(8808):1508-9.
1992: J M Murray; C L Doe; P Schenk; Antony M Carr; Alan Lehmann; Felicity Z Watts
Cloning and characterisation of the S. pombe rad15 gene, a homologue to the S. cerevisiae RAD3 and human ERCC2 genes.
Nucleic acids research 1992;20(11):2673-8.
1992: Deborah E Barnes; Alan E Tomkinson; Alan Lehmann; A D Webster; Tomas Lindahl
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.
Cell 1992;69(3):495-503.
1992: H Steingrimsdottir; G Rowley; Gabriel Dorado; J Cole; Alan Lehmann
Mutations which alter splicing in the human hypoxanthine-guanine phosphoribosyltransferase gene.
Nucleic acids research 1992;20(6):1201-8.
1992: Andrew R Timms; H Steingrimsdottir; Alan Lehmann; Bryn A Bridges
Mutant sequences in the rpsL gene of Escherichia coli B/r: mechanistic implications for spontaneous and ultraviolet light mutagenesis.
Molecular & general genetics : MGG 1992;232(1):89-96.
1992: Alan Lehmann; Jan H J Hoeijmakers; A A van Zeeland; C M Backendorf; Bryn A Bridges; A Collins; Robert Fuchs; G P Margison; R Montesano; Ethel Moustacchi
Workshop on DNA repair.
Mutation research 1992;273(1):1-28.
1991: M Fenech; Antony M Carr; J Murray; Felicity Z Watts; Alan Lehmann
Cloning and characterization of the rad4 gene of Schizosaccharomyces pombe; a gene showing short regions of sequence similarity to the human XRCC1 gene.
Nucleic acids research 1991;19(24):6737-41.
1991: Alan Lehmann; Antony M Carr; F Z Watts; J M Murray
DNA repair in the fission yeast, Schizosaccharomyces pombe.
Mutation research 1991;250(1-2):205-10.
1991: Alexander Anstey; Colin F Arlett; J Cole; P G Norris; A S Hamblin; G Astrid Limb; Alan Lehmann; J D Wilkinson; M Turner
Long-term survival and preservation of natural killer cell activity in a xeroderma pigmentosum patient with spontaneous regression and multiple deposits of malignant melanoma.
The British journal of dermatology 1991;125(3):272-8.
1991: Bernard C Broughton; N Barbet; J Murray; Felicity Z Watts; Marcel Koken; Alan Lehmann; Antony M Carr
Assignment of ten DNA repair genes from Schizosaccharomyces pombe to chromosomal NotI restriction fragments.
Molecular & general genetics : MGG 1991;228(3):470-2.
1991: J M Murray; Antony M Carr; Alan Lehmann; Felicity Z Watts
Cloning and characterisation of the rad9 DNA repair gene from Schizosaccharomyces pombe.
Nucleic acids research 1991;19(13):3525-31.
1991: P G Norris; C F Arlett; J Cole; Alan Lehmann; J L Hawk
Abnormal erythemal response and elevated T lymphocyte HRPT mutant frequency in Cockayne's syndrome.
The British journal of dermatology 1991;124(5):453-60.
1991: W J Muriel; john lamb; Alan Lehmann
UV mutation spectra in cell lines from patients with Cockayne's syndrome and ataxia telangiectasia, using the shuttle vector pZ189.
Mutation research 1991;254(2):119-23.
1991: Gabriel Dorado; H Steingrimsdottir; Colin F Arlett; Alan Lehmann
Molecular analysis of ultraviolet-induced mutations in a xeroderma pigmentosum cell line.
Journal of molecular biology 1991;217(2):217-22.
1990: Bryn A Bridges; A M Carr; Alan Lehmann
Possible methodologies for the detection and study of DNA sequence changes following mutagen exposure: magnetic enrichment in mutant DNA.
Mutagenesis 1990;5(6):523-4.
1990: Alan Lehmann; B A Bridges
Sunlight-induced cancer: some new aspects and implications of the xeroderma pigmentosum model.
The British journal of dermatology 1990;122 Suppl 35():115-9.
1990: Alan Lehmann; P G Norris
DNA repair deficient photodermatoses.
Seminars in dermatology 1990;9(1):55-62.
1990: Bernard C Broughton; Alan Lehmann; S A Harcourt; Colin F Arlett; Alain Sarasin; W J Kleijer; F A Beemer; R Nairn; D L Mitchell
Relationship between pyrimidine dimers, 6-4 photoproducts, repair synthesis and cell survival: studies using cells from patients with trichothiodystrophy.
Mutation research 1990;235(1):33-40.
1990: P G Norris; G Astrid Limb; A S Hamblin; Alan Lehmann; Colin F Arlett; J Cole; Alastair Waugh; J L Hawk
Immune function, mutant frequency, and cancer risk in the DNA repair defective genodermatoses xeroderma pigmentosum, Cockayne's syndrome, and trichothiodystrophy.
The Journal of investigative dermatology 1990;94(1):94-100.
1989: Alan Lehmann
Trichothiodystrophy and the relationship between DNA repair and cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 1989;11(6):168-70.
1989: Alan Lehmann; N G Jaspers; R A Gatti
Fourth International Workshop on Ataxia-Telangiectasia.
Cancer research 1989;49(21):6162-3.
1989: Alan Lehmann; P G Norris
DNA repair and cancer: speculations based on studies with xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy.
Carcinogenesis 1989;10(8):1353-6.
1989: john lamb; C Petit-Frère; Bernard C Broughton; Alan Lehmann; Michael H L Green
Inhibition of DNA replication by ionizing radiation is mediated by a trans-acting factor.
International journal of radiation biology 1989;56(2):125-30.
1989: S W Dean; L Kincla; H R Sykes; Alan Lehmann; I A Wise
Instability of extrachromosomal cosmid DNA in SV40-transformed human (ataxia-telangiectasia) cells.
Experimental cell research 1989;183(2):473-83.
1989: Alan Lehmann; Colin F Arlett; S A Harcourt; H Steingrimsdottir; M M Gebara
Mutagenic treatments result in inactivation of expression of a transfected bacterial gene integrated into a human cell line.
Mutation research 1989;220(2-3):255-62.
1988: Alan Lehmann; A E Willis; Bernard C Broughton; M R James; H Steingrimsdottir; S A Harcourt; Colin F Arlett; T Lindahl
Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome.
Cancer research 1988;48(22):6343-7.
1988: Alan Lehmann; Colin F Arlett; Bernard C Broughton; S A Harcourt; H Steingrimsdottir; M Stefanini; A Malcolm; R Taylor; A T Natarajan; S Green
Trichothiodystrophy, a human DNA repair disorder with heterogeneity in the cellular response to ultraviolet light.
Cancer research 1988;48(21):6090-6.
1988: S W Dean; H R Sykes; Alan Lehmann
Inactivation by nitrogen mustard of plasmids introduced into normal and Fanconi's anaemia cells.
Mutation research 1988;194(1):57-63.
1988: Lynne V Mayne; T Jones; S W Dean; S A Harcourt; Jillian E Lowe; A Priestley; H Steingrimsdottir; H Sykes; Michael H L Green; Alan Lehmann
SV 40-transformed normal and DNA-repair-deficient human fibroblasts can be transfected with high frequency but retain only limited amounts of integrated DNA.
Gene 1988;66(1):65-76.
1988: C N Parris; C F Arlett; Alan Lehmann; M H Green; John R Masters
Differential sensitivities to gamma radiation of human bladder and testicular tumour cell lines.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1988;53(4):599-608.
1987: E C Friedberg; C Backendorf; J Burke; A Collins; L Grossman; J H Hoeijmakers; Alan Lehmann; E Seeberg; G P van der Schans; A A van Zeeland
Molecular aspects of DNA repair.
Mutation research 1987;184(2):67-86.
1987: W J Muriel; J Cole; Alan Lehmann
Molecular analysis of ouabain-resistant mutants of the mouse lymphoma cell line L5178Y.
Mutagenesis 1987;2(5):383-9.
1987: M M Gebara; C Drevon; S A Harcourt; H Steingrimsdottir; M R James; Julian Burke; Colin F Arlett; Alan Lehmann
Inactivation of a transfected gene in human fibroblasts can occur by deletion, amplification, phenotypic switching, or methylation.
Molecular and cellular biology 1987;7(4):1459-64.
1987: G Hilgers; Peter J Abrahams; R Schouten; J J Cornelis; Alan Lehmann; Alex J van der Eb; Jean Rommelaere
[Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus].
Comptes rendus des séances de la Société de biologie et de ses filiales 1987;181(4):432-8.
1987: Michael H L Green; Jillian E Lowe; Colin F Arlett; S A Harcourt; Julian Burke; M R James; Alan Lehmann; S M Povey
A gamma-ray-resistant derivative of an ataxia telangiectasia cell line obtained following DNA-mediated gene transfer.
Journal of cell science. Supplement 1987;6():127-37.
1986: Alan Lehmann; C F Arlett; J F Burke; M H Green; M R James; J E Lowe
A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.
International journal of radiation biology and related studies in physics, chemistry, and medicine 1986;49(4):639-43.
1985: Alan Lehmann
Use of recombinant DNA techniques in cloning DNA repair genes and in the study of mutagenesis in mammalian cells.
Mutation research 1985;150(1-2):61-7.
1985: V Poirier; M R James; C F Arlett; Alan Lehmann
NAD and the synthesis of (ADP-ribose)n in a human cell strain (46BR) hypersensitive to the lethal effects of 3-aminobenzamide.
Carcinogenesis 1985;6(6):837-41.
1985: leigh m henderson; Colin F Arlett; S A Harcourt; Alan Lehmann; Bernard C Broughton
Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchanges.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):2044-8.
1985: Alan Lehmann; A Oomen
Effect of DNA damage on the expression of the chloramphenicol acetyltransferase gene after transfection into diploid human fibroblasts.
Nucleic acids research 1985;13(6):2087-95.
1985: Alan Lehmann; A J Francis; F Giannelli
Prenatal diagnosis of Cockayne's syndrome.
Lancet 1985;1(8427):486-8.
1985: Alan Lehmann
Ageing, DNA repair of radiation damage and carcinogenesis: fact and fiction.
IARC scientific publications 1985;(58):203-13.
1984: Lynne V Mayne; Bernard C Broughton; Alan Lehmann
The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content.
American journal of human genetics 1984;36(2):311-9.
1984: Alan Lehmann; B C Broughton
Poly(ADP-ribosylation) reduces the steady-state level of breaks in DNA following treatment of human cells with alkylating agents.
Carcinogenesis 1984;5(1):117-9.
1983: I A Teo; Alan Lehmann; R Müller; M F Rajewsky
Similar rate of O6-ethylguanine elimination from DNA in normal human fibroblast and xeroderma pigmentosum cell strains not transformed by SV40.
Carcinogenesis 1983;4(8):1075-7.
1983: I A Teo; Bernard C Broughton; R S Day; M R James; P Karran; Lynne V Mayne; Alan Lehmann
A biochemical defect in the repair of alkylated DNA in cells from an immunodeficient patient (46BR).
Carcinogenesis 1983;4(5):559-64.
1982: Alan Lehmann
Three complementation groups in Cockayne syndrome.
Mutation research 1982;106(2):347-56.
1982: L V Mayne; Alan Lehmann; R Waters
Excision repair in Cockayne syndrome.
Mutation research 1982;106(1):179-89.
1982: M R James; Alan Lehmann
Role of poly(adenosine diphosphate ribose) in deoxyribonucleic acid repair in human fibroblasts.
Biochemistry 1982;21(17):4007-13.
1982: L V Mayne; Alan Lehmann
Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum.
Cancer research 1982;42(4):1473-8.
1981: Alan Lehmann
Cancer-associated human genetic diseases with defects in DNA repair.
Journal of cancer research and clinical oncology 1981;100(2):117-24.
1981: Alan Lehmann; P Karran
DNA repair.
International review of cytology 1981;72():101-46.
1980: Colin F Arlett; S A Harcourt; Alan Lehmann; S Stevens; M A Ferguson-Smith; W N Morley
Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.
Carcinogenesis 1980;1(9):745-51.
1980: Alan Lehmann
Early steps in excision repair.
Nature 1980;285(5767):614-5.
1980: A M Rogers; R Hill; Alan Lehmann; C F Arlett; V W Burns
The induction and characterization of mouse lymphoma L5178Y cell lines resistant to 1-beta-d-arabinofuranosylcytosine.
Mutation research 1980;69(1):139-48.
1980: Alan Lehmann; S Stevens
A rapid procedure for measurement of DNA repair in human fibroblasts and for complementation analysis of xeroderma pigmentosum cells.
Mutation research 1980;69(1):177-90.
1979: Alan Lehmann
The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibroblasts.
Nucleic acids research 1979;7(7):1901-12.
1979: Alan Lehmann; S Kirk-Bell; L Mayne
Abnormal kinetics of DNA synthesis in ultraviolet light-irradiated cells from patients with Cockayne's syndrome.
Cancer research 1979;39(10):4237-41.
1979: D McGarva; O P Doubleday; Alan Lehmann; B A Bridges
Assays for the fidelity of DNA polymerases in cell-free extracts of Escherichia coli are complicated by contaminating nucleoside triphosphatases.
Biochimica et biophysica acta 1979;563(2):356-64.
1979: C F Arlett; Alan Lehmann
The UV-response in repair-deficient human syndromes.
Acta biologica et medica Germanica 1979;38(9):1277-83.
1979: Alan Lehmann; S Stevens
The response of ataxia telangiectasia cells to bleomycin.
Nucleic acids research 1979;6(5):1953-60.
1978: Alan Lehmann; S Kirk-Bell
DNA-binding proteins in xeroderma pigmentosum fibroblasts.
Experimental cell research 1978;114(1):197-201.
1978: C F Arlett; Alan Lehmann; F Giannelli; C A Ramsay
A human subject with a new defect in repair of ultraviolet damage.
The Journal of investigative dermatology 1978;70(4):173-7.
1978: Alan Lehmann; S Kirk-Bell
Pyrimidine dimer sites associated with the daughter DNA strands in UV-irradiated human fibroblasts.
Photochemistry and photobiology 1978;27(3):297-307.
1978: W A Cramp; W Köhnlein; Alan Lehmann
Biological functions of DNA and methods of testing.
Molecular biology, biochemistry, and biophysics 1978;27():255-60.
1978: C F Arlett; Alan Lehmann
Human disorders showing increased sensitivity to the induction of genetic damage.
Annual review of genetics 1978;12():95-115.
1978: Alan Lehmann
Repair processes for radiation-induced DNA damage.
Molecular biology, biochemistry, and biophysics 1978;27():312-34.
1977: Alan Lehmann; S Kirk-Bell; C F Arlett; S A Harcourt; E A de Weerd-Kastelein; W Keijzer; P Hall-Smith
Repair of ultraviolet light damage in a variety of human fibroblast cell strains.
Cancer research 1977;37(3):904-10.
1977: Alan Lehmann; C F Arlett
Human genetic disorders with defects in the repair of deoxyribonucleic acid [proceedings].
Biochemical Society transactions 1977;5(4):1199-203.
1977: Alan Lehmann; B A Bridges
DNA repair.
Essays in biochemistry 1977;13():71-119.
1976: C F Arlett; Alan Lehmann; P H Lohman; M C Paterson
Proceedings: Ataxia telangiectasia, radiosensitivity at the cellular and molecular level.
The British journal of radiology 1976;49(582):560-1.
1975: A M Taylor; D G Harnden; C F Arlett; S A Harcourt; Alan Lehmann; S Stevens; B A Bridges
Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity.
Nature 1975;258(5534):427-9.
1975: C F Arlett; D Turnbull; S A Harcourt; Alan Lehmann; C M Colella
A comparison of the 8-azaguanine and ouabain-resistance systems for the selection of induced mutant Chinese hamster cells.
Mutation research 1975;33(2-3):261-78.
1975: K Nilsson; Alan Lehmann
The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells.
Mutation research 1975;30(2):255-66.
1975: Alan Lehmann; S Stevens
Postreplication repair of DNA in chick cells: studies using photoreactivation.
Biochimica et biophysica acta 1975;402(2):179-87.
1975: Alan Lehmann
Postreplication repair of DNA in UV-irradiated mammalian cells.
Basic life sciences 1975;5B():617-23.
1975: Alan Lehmann; S Kirk-Bell; C F Arlett; M C Paterson; P H Lohman; E A de Weerd-Kastelein; D Bootsma
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
Proceedings of the National Academy of Sciences of the United States of America 1975;72(1):219-23.
1974: Alan Lehmann
Postreplication repair of DNA in mammalian cells.
Life sciences 1974;15(12):2005-16.
1974: M H Green; A S Medcalf; C F Arlett; S A Harcourt; Alan Lehmann
DNA strand breakage caused by dichlorvos, methyl methanesulphonate and iodoacetamide in Escherichia coli and cultured Chinese hamster cells.
Mutation research 1974;24(3):365-78.
1974: Alan Lehmann; S Kirk-Bell
Effects of caffeine and theophylline on DNA synthesis in unirradiated and UV-irradiated mammalian cells.
Mutation research 1974;26(2):73-82.
1974: Alan Lehmann; S Kirk-Bell; S Shall; W J Whish
The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells.
Experimental cell research 1974;83(1):63-72.
1972: Alan Lehmann
Post-replication repair of DNA in ultraviolet-irradiated mammalian cells. No gaps in DNA synthesized late after ultraviolet irradiation.
European journal of biochemistry / FEBS 1972;31(3):438-45.
1972: Alan Lehmann
Effect of caffeine on DNA synthesis in mammalian cells.
Biophysical journal 1972;12(10):1316-25.
1972: Alan Lehmann; S Shall
No inhibition of endogenous DNA polymerase by synthesis of poly (ADP-ribose) in nuclei from lymphoid cells.
FEBS letters 1972;26(1):181-4.
1972: Alan Lehmann
Postreplication repair of DNA in ultraviolet-irradiated mammalian cells.
Journal of molecular biology 1972;66(3):319-37.
1971: M G Ormerod; Alan Lehmann
Artefacts arising from the sedimentation of high molecular weight DNA on sucrose gradients.
Biochimica et biophysica acta 1971;247(3):369-72.
1971: M G Ormerod; Alan Lehmann
The release of high molecular weight DNA from a mammalian cell (L-5178Y). Attachment of the DNA to the nuclear membrane.
Biochimica et biophysica acta 1971;228(2):331-43.
1970: Alan Lehmann; M G Ormerod
Double-strand breaks in the DNA of a mammalian cell after x-irradiation.
Biochimica et biophysica acta 1970;217(2):268-77.
1970: Alan Lehmann; M G Ormerod
The replication of DNA in murine lymphoma cells (L5178Y). I. Rate of replication.
Biochimica et biophysica acta 1970;204(1):128-43.
1969: Alan Lehmann; M G Ormerod
Artefact in the measurement of the molecular weight of pulse labelled DNA.
Nature 1969;221(5185):1053-6.