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Erinna Lee

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Chemicals & Drugs

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Genes & Molecular Sequences

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Publications

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Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Delphine Mérino; Belinda Phipson; Mikara Robati; Andrew W Roberts; Cassandra J Vandenberg; Chihunt Wong; Peng Yue; Daniel J Anderson; Lisa D Belmont; Kirsteen J Campbell; Suzanne Cory; W Douglas Fairlie; Stefan P Glaser; David C S Huang; Seong L Khaw; Erinna Lee; Mary J C Ludlam; Philippe Bouillet
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
J Hagen; W Douglas Fairlie; Erinna Lee; Bernd H Kalinna
Functional genomics approaches in parasitic helminths.

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All Publications

2013: Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell 2013;152(3):519-31.
2012: Delphine Mérino; Belinda Phipson; Mikara Robati; Andrew W Roberts; Cassandra J Vandenberg; Chihunt Wong; Peng Yue; Daniel J Anderson; Lisa D Belmont; Kirsteen J Campbell; Suzanne Cory; W Douglas Fairlie; Stefan P Glaser; David C S Huang; Seong L Khaw; Erinna Lee; Mary J C Ludlam; Philippe Bouillet
Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells.
Blood 2012;119(24):5807-16.
2012: J Hagen; W Douglas Fairlie; Erinna Lee; Bernd H Kalinna
Functional genomics approaches in parasitic helminths.
Parasite immunology 2012;34(2-3):163-82.
2012: Stefan P Glaser; Marco J Herold; David J Izon; Erinna Lee; Scott W Lowe; Amy R Rappaport; Lorraine Robb; Warren S Alexander; Philippe Bouillet; W Douglas Fairlie; Evelyn Trounson; Andrew Wei; Johannes Zuber; Andreas Strasser
Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia.
Genes & development 2012;26(2):120-5.
2012: C Wong; D J Anderson; W D Fairlie; Erinna Lee; M J C Ludlam
Direct visualization of Bcl-2 family protein interactions using live cell fluorescent protein redistribution assays.
Cell death & disease 2012;3():e288.
2011: Erinna Lee; Matthew A Perugini; Anne Pettikiriarachchi; Brian J Smith; Peter M Colman; Grant Dewson; C Dogovski; Marco Evangelista; W Douglas Fairlie
Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.
Structure (London, England : 1993) 2011;19(10):1467-76.
2011: Erinna Lee; Kelsey N Mayer; Brian J Smith; Peter M Colman; Marco Evangelista; Samuel H Gellman; W Seth Horne; W Douglas Fairlie
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design.
Chembiochem : a European journal of chemical biology 2011;12(13):2025-32.
2011: Erinna Lee; Oliver B Clarke; Marco Evangelista; Zhiping Feng; Terence P Speed; Elissaveta B Tchoubrieva; Andreas Strasser; Bernd H Kalinna; Peter M Colman; W Douglas Fairlie
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6999-7003.
2009: James E Vince; Delara Pantaki; Rebecca Feltham; Peter D Mace; Stephanie M Cordier; Anna C Schmukle; Angelina J Davidson; Bernard A Callus; Wendy Wei-Lynn Wong; Ian Gentle; Holly Carter; Erinna Lee; Henning Walczak; Catherine L Day; David L Vaux; John Silke
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
The Journal of biological chemistry 2009;284(51):35906-15.
2009: Erinna Lee; Anna Fedorova; Kerry Zobel; Michelle J Boyle; Hong Yang; Matthew A Perugini; Peter M Colman; David C S Huang; Kurt Deshayes; W Douglas Fairlie
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.
The Journal of biological chemistry 2009;284(45):31315-26.
2009: Delphine Mérino; Maybelline Giam; Peter D Hughes; Owen M Siggs; Klaus Heger; Lorraine A O'Reilly; Jerry M Adams; Andreas Strasser; Erinna Lee; W Douglas Fairlie; Philippe Bouillet
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins.
The Journal of cell biology 2009;186(3):355-62.
2008: Jamie I Fletcher; Sarina Meusburger; Christine J Hawkins; David T Riglar; Erinna Lee; W Douglas Fairlie; David C S Huang; Jerry M Adams
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18081-7.
2008: Erinna Lee; L Chen; H Yang; P M Colman; D C S Huang; W D Fairlie
EGL-1 BH3 mutants reveal the importance of protein levels and target affinity for cell-killing potency.
Cell death and differentiation 2008;15(10):1609-18.
2008: Catherine L Day; Callum Smits; F Cindy Fan; Erinna Lee; W Douglas Fairlie; Mark G Hinds
Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1.
Journal of molecular biology 2008;380(5):958-71.
2008: Erinna Lee; Peter Czabotar; Mark F Van Delft; Ewa M Michalak; Michelle J Boyle; Simon N Willis; Hamsa Puthalakath; Philippe Bouillet; Peter M Colman; David C S Huang; W Douglas Fairlie
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
The Journal of cell biology 2008;180(2):341-55.
2007: Erinna Lee; Peter Czabotar; Brian J Smith; Kurt Deshayes; Kerry Zobel; Peter M Colman; W Douglas Fairlie
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.
Cell death and differentiation 2007;14(9):1711-3.
2007: Peter Czabotar; Erinna Lee; Mark F Van Delft; Catherine L Day; Brian J Smith; David C S Huang; W Douglas Fairlie; Mark G Hinds; Peter M Colman
Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6217-22.
2007: Marc Kvansakul; Mark F Van Delft; Erinna Lee; Jacqueline M Gulbis; W Douglas Fairlie; David C S Huang; Peter M Colman
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Molecular cell 2007;25(6):933-42.
2007: Simon N Willis; Jamie I Fletcher; Thomas Kaufmann; Mark F Van Delft; Lin Chen; Peter Czabotar; Helen Ierino; Erinna Lee; W Douglas Fairlie; Philippe Bouillet; Andreas Strasser; Ruth M Kluck; Jerry M Adams; David C S Huang
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Science (New York, N.Y.) 2007;315(5813):856-9.
2005: Karen S Harris; Joanne L Casey; Andrew M Coley; Rosella Masciantonio; Jennifer K Sabo; David Keizer; Erinna Lee; Andrew McMahon; Raymond S Norton; Robin F Anders; Michael Foley
Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1.
Infection and immunity 2005;73(10):6981-9.
2004: W Douglas Fairlie; Alessandro D Uboldi; Joanne E McCoubrie; Chunxiao C Wang; Erinna Lee; Shenggen Yao; David P De Souza; Sandra Mifsud; Donald Metcalf; Nicos A Nicola; Raymond S Norton; Manuel Baca
Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.
The Journal of biological chemistry 2004;279(3):2125-34.
2003: David Keizer; Peter J. West; Erinna Lee; Doju Yoshikami; Baldomero M Olivera; Grzegorz Bulaj; Raymond S Norton
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA.
The Journal of biological chemistry 2003;278(47):46805-13.