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Sadashiva Karnik

Research Profile

Chemicals & Drugs

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Publications

TOP 3
Hamiyet Unal; Kalyan Tirupula; Anushree Bhatnagar; Russell Desnoyer; Rajaganapathi Jagannathan; Sadashiva Karnik
Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor.
Anushree Bhatnagar; Russell Desnoyer; Zhong-Hui Duan; Rajaganapathi Jagannathan; Suma Kaveti; Michael Kinter; Hamiyet Unal; Amit Vasanji; Sandro Yong; Sadashiva Karnik
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation.
Sadashiva Karnik; Hamiyet Unal
Angiotensin II receptor-induced cardiac remodeling in mice without angiotensin II.

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All Publications

2013: Hamiyet Unal; Kalyan Tirupula; Anushree Bhatnagar; Russell Desnoyer; Rajaganapathi Jagannathan; Sadashiva Karnik
Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor.
The Journal of biological chemistry 2013;288(1):540-51.
2013: Anushree Bhatnagar; Russell Desnoyer; Zhong-Hui Duan; Rajaganapathi Jagannathan; Suma Kaveti; Michael Kinter; Hamiyet Unal; Amit Vasanji; Sandro Yong; Sadashiva Karnik
Interaction of G-protein βγ complex with chromatin modulates GPCR-dependent gene regulation.
PloS one 2013;8(1):e52689.
2012: Sadashiva Karnik; Hamiyet Unal
Angiotensin II receptor-induced cardiac remodeling in mice without angiotensin II.
Hypertension 2012;59(3):542-4.
2012: Yoshihiro Kiya; Yoshino Matsuo; Shin-Ichiro Miura; Sadashiva Karnik; Keijiro Saku
Abilities of candesartan and other AT(1) receptor blockers to impair angiotensin II-induced AT(1) receptor activation after wash-out.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2012;13(1):76-83.
2012: Hamiyet Unal; Sadashiva Karnik
Domain coupling in GPCRs: the engine for induced conformational changes.
Trends in pharmacological sciences 2012;33(2):79-88.
2012: Shin-Ichiro Miura; Naoki Nakao; Hiroaki Yanagisawa; Masahiro Fujino; Hiroyuki Hanzawa; Satoshi Imaizumi; Sadashiva Karnik; Yoshihiro Kiya; Hiroyuki Koike; Issei Komuro; Yoshino Matsuo; Keijiro Saku
Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.
PloS one 2012;7(6):e37974.
2011: Shin-Ichiro Miura; Sadashiva Karnik; Keijiro Saku
Review: angiotensin II type 1 receptor blockers: class effects versus molecular effects.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2011;12(1):1-7.
2010: Masahiro Fujino; Shin-Ichiro Miura; Yoshihiro Kiya; Yukio Tominaga; Yoshino Matsuo; Sadashiva Karnik; Keijiro Saku
A small difference in the molecular structure of angiotensin II receptor blockers induces AT₁ receptor-dependent and -independent beneficial effects.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(10):1044-52.
2010: Sathyamangla V Naga Prasad; Sadashiva Karnik
MicroRNAs--regulators of signaling networks in dilated cardiomyopathy.
Journal of cardiovascular translational research 2010;3(3):225-34.
2010: Hamiyet Unal; Rajaganapathi Jagannathan; Manjunatha B Bhat; Sadashiva Karnik
Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor.
The Journal of biological chemistry 2010;285(21):16341-50.
2010: Rajaganapathi Jagannathan; Suma Kaveti; RW Desnoyer; Belinda Willard; Michael Kinter; Sadashiva Karnik
AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling.
PloS one 2010;5(9):e12552.
2010: Yoshihiro Kiya; Shin-Ichiro Miura; Masahiro Fujino; Satoshi Imaizumi; Sadashiva Karnik; Keijiro Saku
Clinical and pharmacotherapeutic relevance of the double-chain domain of the angiotensin II type 1 receptor blocker olmesartan.
Clinical and experimental hypertension (New York, N.Y. : 1993) 2010;32(2):129-36.
2010: Shin-ichiro Miura; Yoshino Matsuo; Yoshihiro Kiya; Sadashiva Karnik; Keijiro Saku
Molecular mechanisms of the antagonistic action between AT1 and AT2 receptors.
Biochemical and biophysical research communications 2010;391(1):85-90.
2010: Hong Yue; Wei Li; Russell Desnoyer; Sadashiva Karnik
Role of nuclear unphosphorylated STAT3 in angiotensin II type 1 receptor-induced cardiac hypertrophy.
Cardiovascular research 2010;85(1):90-9.
2009: Sathyamangla V Naga Prasad; Zhong-Hui Duan; Manveen K Gupta; Venkata Suresh K Surampudi; Stefano Volinia; George A Calin; Chang-gong liu; Ashwin Kotwal; Christine S Moravec; Randall C Starling; Dianne M Perez; Subha Sen; Qingyu Wu; Edward F Plow; Carlo M Croce; Sadashiva Karnik
Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks.
The Journal of biological chemistry 2009;284(40):27487-99.
2009: Sei-Heon Jang; Si Ae Hwang; Mijin Kim; Sung-Hae Yun; Moon-Sook Kim; Sadashiva Karnik; ChangWoo Lee
A protein tyrosine phosphatase inhibitor, pervanadate, inhibits angiotensin II-Induced beta-arrestin cleavage.
Molecules and cells 2009;28(1):25-30.
2008: ChangWoo Lee; Sumantha Bhatt; Anita Shukla; RW Desnoyer; Satya P Yadav; Mijin Kim; Sei-Heon Jang; Sadashiva Karnik
Site-specific cleavage of G protein-coupled receptor-engaged beta-arrestin. Influence of the AT1 receptor conformation on scissile site selection.
The Journal of biological chemistry 2008;283(31):21612-20.
2008: Shin-Ichiro Miura; Yoshihiro Kiya; Takanori Kanazawa; Satoshi Imaizumi; Masahiro Fujino; Yoshino Matsuo; Sadashiva Karnik; Keijiro Saku
Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state.
Molecular endocrinology (Baltimore, Md.) 2008;22(1):139-46.
2007: Preenie deS Senanayake; Judith A Drazba; Karen G Shadrach; Amy Milsted; Elisabeth Rungger-Brandle; Kazutoshi Nishiyama; Shin-Ichiro Miura; Sadashiva Karnik; Jonathan E Sears; Joe G Hollyfield
Angiotensin II and its receptor subtypes in the human retina.
Investigative ophthalmology & visual science 2007;48(7):3301-11.
2007: ChangWoo Lee; Si Ae Hwang; Sei-Heon Jang; Hye-Shin Chung; Manjunatha B Bhat; Sadashiva Karnik
Manifold active-state conformations in GPCRs: agonist-activated constitutively active mutant AT1 receptor preferentially couples to Gq compared to the wild-type AT1 receptor.
FEBS letters 2007;581(13):2517-22.
2006: Ramaswamy Ramchandran; Takanobu Takezako; Yasser Saad; Linda Stull; Bruno Fink; Hirotsugu Yamada; Sergey Dikalov; David G Harrison; Christine S Moravec; Sadashiva Karnik
Angiotensinergic stimulation of vascular endothelium in mice causes hypotension, bradycardia, and attenuated angiotensin response.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(50):19087-92.
2006: Shin-ichiro Miura; Masahiro Fujino; Hiroyuki Hanzawa; Yoshihiro Kiya; Satoshi Imaizumi; Yoshino Matsuo; Sayo Tomita; Yoshinari Uehara; Sadashiva Karnik; Hiroaki Yanagisawa; Hiroyuki Koike; Issei Komuro; Keijiro Saku
Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor.
The Journal of biological chemistry 2006;281(28):19288-95.
2006: Camelia Baleanu-Gogonea; Sadashiva Karnik
Model of the whole rat AT1 receptor and the ligand-binding site.
Journal of molecular modeling 2006;12(3):325-37.
2005: Ying-Hong Feng; Yaxian Ding; Shuo Ren; Lingyin Zhou; Chuan Xu; Sadashiva Karnik
Unconventional homologous internalization of the angiotensin II type-1 receptor induced by G-protein-independent signals.
Hypertension 2005;46(2):419-25.
2005: Dianne M Perez; Sadashiva Karnik
Multiple signaling states of G-protein-coupled receptors.
Pharmacological reviews 2005;57(2):147-61.
2005: Shin-Ichiro Miura; Sadashiva Karnik; Keijiro Saku
Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation.
The Journal of biological chemistry 2005;280(18):18237-44.
2004: Thomas J Pucadyil; Shanti Kalipatnapu; Kaleeckal harikumar; Nandini Rangaraj; Sadashiva Karnik; Amitabha Chattopadhyay
G-protein-dependent cell surface dynamics of the human serotonin1A receptor tagged to yellow fluorescent protein.
Biochemistry 2004;43(50):15852-62.
2004: Shin-ichiro Miura; Jingli Zhang; Yoshino Matsuo; Keijiro Saku; Sadashiva Karnik
Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(10):765-70.
2004: Takanobu Takezako; Camelia Gogonea; Yasser Saad; Keita Noda; Sadashiva Karnik
"Network leaning" as a mechanism of insurmountable antagonism of the angiotensin II type 1 receptor by non-peptide antagonists.
The Journal of biological chemistry 2004;279(15):15248-57.
2004: Mohammed Yousufuddin; Showkat A Haji; Randall C Starling; E Murat Tuzcu; Norman B Ratliff; Daniel Cook; Ashraf Abdo; Yasser Saad; Sadashiva Karnik; Duolao Wang; Patrick M McCarthy; James B Young; Mohamad H Yamani
Cardiac angiotensin II receptors as predictors of transplant coronary artery disease following heart transplantation.
European heart journal 2004;25(5):377-85.
2003: Shin-ichiro Miura; Keijiro Saku; Sadashiva Karnik
Molecular analysis of the structure and function of the angiotensin II type 1 receptor.
Hypertension research : official journal of the Japanese Society of Hypertension 2003;26(12):937-43.
2003: Sadashiva Karnik; Camelia Gogonea; Supriya Patil; Yasser Saad; Takanobu Takezako
Activation of G-protein-coupled receptors: a common molecular mechanism.
Trends in endocrinology and metabolism: TEM 2003;14(9):431-7.
2003: Huijun Wei; Seungkirl Ahn; Sudha K Shenoy; Sadashiva Karnik; László Hunyady; Louis M Luttrell; Robert J Lefkowitz
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10782-7.
2003: Shin-ichiro Miura; Jingli Zhang; John Boros; Sadashiva Karnik
TM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptor.
The Journal of biological chemistry 2003;278(6):3720-5.
2002: Shin-Ichiro Miura; Sadashiva Karnik
Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2.
The Journal of biological chemistry 2002;277(27):24299-305.
2002: Alice C Holloway; Hongwei Qian; Luisa Pipolo; James Ziogas; Shin-ichiro Miura; Sadashiva Karnik; Bridget R Southwell; Michael J Lew; Walter G Thomas
Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors.
Molecular pharmacology 2002;61(4):768-77.
2002: Sadashiva Karnik
Analysis of structure-function from expression of G protein-coupled receptor fragments.
Methods in enzymology 2002;343():248-59.
2000: Ying-Hong Feng; Yasser Saad; Sadashiva Karnik
Reversible inactivation of AT(2) angiotensin II receptor from cysteine-disulfide bond exchange.
FEBS letters 2000;484(2):133-8.
2000: Shin-Ichiro Miura; Sadashiva Karnik
Ligand-independent signals from angiotensin II type 2 receptor induce apoptosis.
The EMBO journal 2000;19(15):4026-35.
2000: Shin-Ichiro Miura; Jingli Zhang; Sadashiva Karnik
Angiotensin II type 1 receptor-function affected by mutations in cytoplasmic loop CD.
FEBS letters 2000;470(3):331-5.
2000: Walter G Thomas; H Qian; C S Chang; Sadashiva Karnik
Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state.
The Journal of biological chemistry 2000;275(4):2893-900.
1999: Ying-Hong Feng; Sadashiva Karnik
Role of transmembrane helix IV in G-protein specificity of the angiotensin II type 1 receptor.
The Journal of biological chemistry 1999;274(50):35546-52.
1999: Shin-Ichiro Miura; Ying-Hong Feng; A Husain; Sadashiva Karnik
Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor.
The Journal of biological chemistry 1999;274(11):7103-10.
1999: Shin-Ichiro Miura; Sadashiva Karnik
Angiotensin II type 1 and type 2 receptors bind angiotensin II through different types of epitope recognition.
Journal of hypertension 1999;17(3):397-404.
1998: Ying-Hong Feng; Shin-Ichiro Miura; A Husain; Sadashiva Karnik
Mechanism of constitutive activation of the AT1 receptor: influence of the size of the agonist switch binding residue Asn(111).
Biochemistry 1998;37(45):15791-8.
1997: S Acharya; Yasser Saad; Sadashiva Karnik
Transducin-alpha C-terminal peptide binding site consists of C-D and E-F loops of rhodopsin.
The Journal of biological chemistry 1997;272(10):6519-24.
1997: Y Liao; Taolin Yi; B D Hoit; R A Walsh; Sadashiva Karnik; A Husain
Selective reporter expression in mast cells using a chymase promoter.
The Journal of biological chemistry 1997;272(5):2969-76.
1997: S Sanker; Unni M Chandrasekharan; Dennis Wilk; M J Glynias; Sadashiva Karnik; A Husain
Distinct multisite synergistic interactions determine substrate specificities of human chymase and rat chymase-1 for angiotensin II formation and degradation.
The Journal of biological chemistry 1997;272(5):2963-8.
1996: K Noda; Ying-Hong Feng; X P Liu; Y Saad; A Husain; Sadashiva Karnik
The active state of the AT1 angiotensin receptor is generated by angiotensin II induction.
Biochemistry 1996;35(51):16435-42.
1996: S Acharya; Sadashiva Karnik
Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin.
The Journal of biological chemistry 1996;271(41):25406-11.
1996: Sadashiva Karnik; A Husain; R M Graham
Molecular determinants of peptide and non-peptide binding to the AT1 receptor.
Clinical and experimental pharmacology & physiology 1996;23 Suppl 3():S58-66.
1996: U M Chandrasekharan; S Sanker; M J Glynias; Sadashiva Karnik; A Husain
Angiotensin II-forming activity in a reconstructed ancestral chymase.
Science (New York, N.Y.) 1996;271(5248):502-5.
1996: Sadashiva Karnik; A Husain; R M Graham
Molecular determinants of peptide and non-peptide binding to the AT1 receptor.
Clinical and experimental pharmacology & physiology. Supplement 1996;3():S58-66.
1995: K Noda; Y Saad; Sadashiva Karnik
Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation.
The Journal of biological chemistry 1995;270(48):28511-4.
1995: Ying-Hong Feng; K Noda; Y Saad; X P Liu; A Husain; Sadashiva Karnik
The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism.
The Journal of biological chemistry 1995;270(21):12846-50.
1995: M Murakami; Sadashiva Karnik; A Husain
Human prochymase activation. A novel role for heparin in zymogen processing.
The Journal of biological chemistry 1995;270(5):2218-23.
1995: K Noda; Y Saad; A Kinoshita; T P Boyle; R M Graham; A Husain; Sadashiva Karnik
Tetrazole and carboxylate groups of angiotensin receptor antagonists bind to the same subsite by different mechanisms.
The Journal of biological chemistry 1995;270(5):2284-9.
1994: K Noda; Y Saad; R M Graham; Sadashiva Karnik
The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines.
The Journal of biological chemistry 1994;269(9):6743-52.
1993: H Urata; Sadashiva Karnik; R M Graham; A Husain
Dipeptide processing activates recombinant human prochymase.
The Journal of biological chemistry 1993;268(32):24318-22.
1993: Sadashiva Karnik; Kevin D Ridge; S Bhattacharya; H Gobind Khorana
Palmitoylation of bovine opsin and its cysteine mutants in COS cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(1):40-4.
1990: Sadashiva Karnik; T Doi; R Molday; H Gobind Khorana
Expression of the archaebacterial bacterio-opsin gene with and without signal sequences in Escherichia coli: the expressed proteins are located in the membrane but bind retinal poorly.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8955-9.
1990: Sadashiva Karnik; H Gobind Khorana
Assembly of functional rhodopsin requires a disulfide bond between cysteine residues 110 and 187.
The Journal of biological chemistry 1990;265(29):17520-4.
1988: Sadashiva Karnik; Thomas P Sakmar; H B Chen; H Gobind Khorana
Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8459-63.
1988: M Braiman; J Bubis; T Doi; H B Chen; S L Flitsch; R R Franke; M A Gilles-Gonzalez; R M Graham; Sadashiva Karnik; H Gobind Khorana
Studies on light transduction by bacteriorhodopsin and rhodopsin.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():355-64.
1987: Sadashiva Karnik; M Nassal; T Doi; E Jay; V Sgaramella; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. II. Improved expression of the bacterio-opsin gene in Escherichia coli.
The Journal of biological chemistry 1987;262(19):9255-63.
1987: M Nassal; Tatsushi Mogi; Sadashiva Karnik; H Gobind Khorana
Structure-function studies on bacteriorhodopsin. III. Total synthesis of a gene for bacterio-opsin and its expression in Escherichia coli.
The Journal of biological chemistry 1987;262(19):9264-70.
1986: L Ferretti; Sadashiva Karnik; H Gobind Khorana; M Nassal; D D Oprian
Total synthesis of a gene for bovine rhodopsin.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(3):599-603.
1983: Sadashiva Karnik; K P Gopinathan
Transfection of Mycobacterium smegmatis SN2 with mycobacteriophage I3 DNA.
Archives of microbiology 1983;136(4):275-80.
1983: Sadashiva Karnik; M Billeter
The lysis function of RNA bacteriophage Qbeta is mediated by the maturation (A2) protein.
The EMBO journal 1983;2(9):1521-6.
1981: Sadashiva Karnik; K P Gopinathan
Presence of nucleoside triphosphates and calcium associated with mycobacteriophage 13.
Archives of microbiology 1981;130(1):50-3.
1980: Sadashiva Karnik; K P Gopinathan
Possible involvement of a calcium-stimulated ATP-hydrolyzing activity associated with mycobacteriophage I3 in the DNA injection process.
Journal of virology 1980;33(3):969-75.
1976: P G Bhat; Sadashiva Karnik; T N Pattabiraman
Natural plant enzyme inhibitors: Part III-purification of protease inhibitors from Lathyrus sativus seeds.
Indian journal of biochemistry & biophysics 1976;13(4):339-43.