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Hyacinth Akunne

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Michael J Konkel; Bharat Lagu; Lakmal W Boteju; Hermogenes Jimenez; Stewart Noble; Mary Walker; Gamini Chandrasena; Thomas Blackburn; Sham S Nikam; Jon L Wright; Brian E Kornberg; Tracy Gregory; Thomas A Pugsley; Hyacinth Akunne; Kim Zoski; Lawrence D Wise
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Thomas A Pugsley; Yu Hsin Shih; Steven Whetzel; Kim Zoski; Don Van Leeuwen; Hyacinth Akunne; Robert George MacKenzie; Thomas G Heffner; David J Wustrow; Lawrence D Wise
The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists.
Hyacinth Akunne; Kim Zoski; Steven Whetzel; J J Cordon; R M Brandon; F Roman; Thomas A Pugsley
Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant.

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2006: Michael J Konkel; Bharat Lagu; Lakmal W Boteju; Hermogenes Jimenez; Stewart Noble; Mary Walker; Gamini Chandrasena; Thomas Blackburn; Sham S Nikam; Jon L Wright; Brian E Kornberg; Tracy Gregory; Thomas A Pugsley; Hyacinth Akunne; Kim Zoski; Lawrence D Wise
3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists.
Journal of medicinal chemistry 2006;49(13):3757-8.
2002: Thomas A Pugsley; Yu Hsin Shih; Steven Whetzel; Kim Zoski; Don Van Leeuwen; Hyacinth Akunne; Robert George MacKenzie; Thomas G Heffner; David J Wustrow; Lawrence D Wise
The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists.
Progress in neuro-psychopharmacology & biological psychiatry 2002;26(2):219-26.
2001: Hyacinth Akunne; Kim Zoski; Steven Whetzel; J J Cordon; R M Brandon; F Roman; Thomas A Pugsley
Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant.
Neuropharmacology 2001;41(1):138-49.
2000: Hyacinth Akunne; Kim Zoski; Michael Davis; L W Cooke; Leonard T Meltzer; Steven Whetzel; Yu Hsin Shih; David J Wustrow; Lawrence D Wise; Robert George MacKenzie; LM Georgic; Thomas G Heffner; Thomas A Pugsley
PD 158771, a potential antipsychotic agent with D(2)/D(3) partial agonist and 5-HT(1A) agonist actions. I. Neurochemical effects.
Neuropharmacology 2000;39(7):1197-210.
1999: Thomas R Belliotti; David J Wustrow; W A Brink; Kim Zoski; Yu Hsin Shih; Steven Whetzel; LM Georgic; AE Corbin; Hyacinth Akunne; Thomas G Heffner; Thomas A Pugsley; Lawrence D Wise
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.
Journal of medicinal chemistry 1999;42(25):5181-7.
1998: David J Wustrow; Thomas Capiris; R Rubin; J A Knobelsdorf; Hyacinth Akunne; Michael Davis; Robert George MacKenzie; Thomas A Pugsley; Kim Zoski; Thomas G Heffner; Lawrence D Wise
Pyrazolo[1,5-a]pyrimidine CRF-1 receptor antagonists.
Bioorganic & medicinal chemistry letters 1998;8(16):2067-70.
1998: David J Wustrow; Thomas R Belliotti; SA Glase; S R Kesten; D Johnson; N Colbry; R Rubin; A Blackburn; Hyacinth Akunne; AE Corbin; Michael Davis; LM Georgic; Steven Whetzel; Kim Zoski; Thomas G Heffner; Thomas A Pugsley; L Wise
Aminopyrimidines with high affinity for both serotonin and dopamine receptors.
Journal of medicinal chemistry 1998;41(5):760-71.
1998: AE Corbin; Thomas A Pugsley; Hyacinth Akunne; Steven Whetzel; Kim Zoski; LM Georgic; C B Nelson; Jon L Wright; Lawrence D Wise; Thomas G Heffner
Pharmacological characterization of PD 152255, a novel dimeric benzimidazole dopamine D3 antagonist.
Pharmacology, biochemistry, and behavior 1998;59(2):487-93.
1997: Steven Whetzel; Yu Hsin Shih; LM Georgic; Hyacinth Akunne; Thomas A Pugsley
Effects of the dopamine D3 antagonist PD 58491 and its interaction with the dopamine D3 agonist PD 128907 on brain dopamine synthesis in rat.
Journal of neurochemistry 1997;69(6):2363-8.
1997: SA Glase; Hyacinth Akunne; LM Georgic; Thomas G Heffner; Robert George MacKenzie; P J Manley; Thomas A Pugsley; Lawrence D Wise
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: selective dopamine D4 agonists.
Journal of medicinal chemistry 1997;40(12):1771-2.
1997: Hyacinth Akunne; Steven Whetzel; JN Wiley; AE Corbin; FW Ninteman; H Tecle; Y Pei; Thomas A Pugsley; Thomas G Heffner
The pharmacology of the novel and selective sigma ligand, PD 144418.
Neuropharmacology 1997;36(1):51-62.
1996: L A van Vliet; P G Tepper; D Dijkstra; G Damsma; H Wikström; Thomas A Pugsley; Hyacinth Akunne; Thomas G Heffner; S A Glase; Lawrence D Wise
Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.
Journal of medicinal chemistry 1996;39(21):4233-7.
1996: S A Glase; Hyacinth Akunne; Thomas G Heffner; JC Jaen; Robert George MacKenzie; Leonard T Meltzer; Thomas A Pugsley; S J Smith; Lawrence D Wise
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Journal of medicinal chemistry 1996;39(16):3179-87.
1996: Hyacinth Akunne; S Darling; Kim Zoski; A M Sefler; JX He; T K Sawyer; Thomas A Pugsley; Wayne L Cody
Functional activity of new C-terminal cyclic-neurotensin fragment analogs.
Neuropeptides 1996;30(3):213-8.
1995: Thomas A Pugsley; Michael Davis; Hyacinth Akunne; Robert George MacKenzie; Yu Hsin Shih; G Damsma; H Wikstrom; Steven Whetzel; LM Georgic; L W Cooke
Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.
The Journal of pharmacology and experimental therapeutics 1995;275(3):1355-66.
1995: L H Claye; Hyacinth Akunne; Michael Davis; S DeMattos; Karam Soliman
Behavioral and neurochemical changes in the dopaminergic system after repeated cocaine administration.
Molecular neurobiology 1995;11(1-3):55-66.
1995: T A Rugsley; Michael Davis; Hyacinth Akunne; L W Cooke; Steven Whetzel; Robert George MacKenzie; Yu Hsin Shih; D H van Leeuwen; S B DeMattos; LM Georgic
CI-1007, a dopamine partial agonist and potential antipsychotic agent. I. Neurochemical effects.
The Journal of pharmacology and experimental therapeutics 1995;274(2):898-911.
1995: Hyacinth Akunne; S B Demattos; Steven Whetzel; David J Wustrow; D M Davis; Lawrence D Wise; Wayne L Cody; Thomas A Pugsley; Thomas G Heffner
Agonist properties of a stable hexapeptide analog of neurotensin, N alpha MeArg-Lys-Pro-Trp-tLeu-Leu (NT1).
Biochemical pharmacology 1995;49(8):1147-54.
1995: A M Sefler; JX He; T K Sawyer; K E Holub; D O Omecinsky; M D Reily; V Thanabal; Hyacinth Akunne; Wayne L Cody
Design and structure-activity relationships of C-terminal cyclic neurotensin fragment analogues.
Journal of medicinal chemistry 1995;38(2):249-57.
1995: Thomas A Pugsley; Hyacinth Akunne; Steven Whetzel; S Demattos; AE Corbin; J N Wiley; David J Wustrow; Lawrence D Wise; Thomas G Heffner
Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists.
Peptides 1995;16(1):37-44.
1995: Hyacinth Akunne; P Towers; G J Ellis; D Dijkstra; H Wikström; Thomas G Heffner; Lawrence D Wise; Thomas A Pugsley
Characterization of binding of [3H]PD 128907, a selective dopamine D3 receptor agonist ligand, to CHO-K1 cells.
Life sciences 1995;57(15):1401-10.
1994: D L Heyl; A M Sefler; JX He; T K Sawyer; David J Wustrow; Hyacinth Akunne; Michael Davis; Thomas A Pugsley; Thomas G Heffner; AE Corbin
Structure-activity and conformational studies of a series of modified C-terminal hexapeptide neurotensin analogues.
International journal of peptide and protein research 1994;44(3):233-8.
1994: Hyacinth Akunne; Karam Soliman
Serotonin modulation of pain responsiveness in the aged rat.
Pharmacology, biochemistry, and behavior 1994;48(2):411-6.
1993: JC Jaen; B W Caprathe; Thomas A Pugsley; Lawrence D Wise; Hyacinth Akunne
Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and sigma receptors.
Journal of medicinal chemistry 1993;36(24):3929-36.
1990: J V Lee; Hyacinth Akunne; Karam Soliman
Involvement of the brain cholinergic system in the rapid development of tolerance to glucose-induced analgesia.
Archives internationales de pharmacodynamie et de thérapie 1990;306():34-44.
1988: Hyacinth Akunne; Karam Soliman
Hyperglycemic suppression of morphine withdrawal signs in the rat.
Psychopharmacology 1988;96(1):1-6.
1987: Hyacinth Akunne; Karam Soliman
The role of opioid receptors in diabetes and hyperglycemia-induced changes in pain threshold in the rat.
Psychopharmacology 1987;93(2):167-72.