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Gerrit Los
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Research Profile (preview)
Chemicals & Drugs
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Procedures
Physiology
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Network (preview)
18
Howell, Stephen
7
Christen, RD
5
de las Alas, Maida
5
PINEDO, HERBERT
4
Aebi, Stefan
4
Orloff, Lisa
4
Robbins, Thomas
4
Ruevekamp, Marjan
4
Kirmani, S
3
Gately, DP
3
Breaux, James
3
Manorek, Gerald
3
Vermeulen, Nico
3
Jones, Jeffrey
2
Alton, Gordon
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Geonetwork of Gerrit Los (preview)
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All Publications
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2008: Zhang Cathy; Lundgren Karen; Yan Zhengming; Arango Maria E; Price Sharon; Huber Andrea; Higgins Joseph; Troche Gabriel; Skaptason Judith; Koudriakova Tatiana; Nonomiya Jim; Yang Michelle; O'Connor Patrick; Bender Steve; Los Gerrit; Lewis Cristina; Jessen Bart
Pharmacologic properties of AG-012986, a pan-cyclin-dependent kinase inhibitor with antitumor efficacy.
Molecular cancer therapeutics 2008;7(4):818-28.
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2007: Christensen James G; Zou Helen Y; Arango Maria E; Li Qiuhua; Lee Joseph H; McDonnell Scott R; Yamazaki Shinji; Alton Gordon R; Mroczkowski Barbara; Los Gerrit
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.
Molecular cancer therapeutics 2007;6(12 Pt 1):3314-22.
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2007: Zou Helen Y; Li Qiuhua; Lee Joseph H; Arango Maria E; McDonnell Scott R; Yamazaki Shinji; Koudriakova Tatiana B; Alton Gordon; Cui Jingrong J; Kung Pei-Pei; Nambu Mitchell D; Los Gerrit; Bender Steven L; Mroczkowski Barbara; Christensen James G
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Cancer research 2007;67(9):4408-17.
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2005: Bauer Joshua A; Trask Douglas K; Kumar Bhavna; Los Gerrit; Castro Jason; Lee Julia Shin-Jung; Chen Jianyong; Wang Shaomeng; Bradford Carol R; Carey Thomas E
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.
Molecular cancer therapeutics 2005;4(7):1096-104.
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2005: Samimi Goli; Manorek Gerald; Castel Rob; Breaux James K; Cheng Tim C; Berry Charles C; Los Gerrit; Howell Stephen B
cDNA microarray-based identification of genes and pathways associated with oxaliplatin resistance.
Cancer chemotherapy and pharmacology 2005;55(1):1-11.
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2005: Breaux James K; Los Gerrit
Gene expression profiling to characterize anticancer drug sensitivity.
Methods in molecular medicine 2005;111():197-231.
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2003: Cruz-Monserrate Zobeida; Vervoort Hélène C; Bai Ruoli; Newman David J; Howell Stephen B; Los Gerrit; Mullaney Jeffrey T; Williams Michael D; Pettit George R; Fenical William; Hamel Ernest
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
Molecular pharmacology 2003;63(6):1273-80.
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2002: de las Alas Maida M; Los Gerrit; Lin Xinjian; Kurdi-Haidar Buran; Manorek Gerald; Howell Stephen B
Identification of transdominant-negative genetic suppressor elements derived from hMSH2 that mediate resistance to 6-thioguanine.
Molecular pharmacology 2002;62(5):1198-206.
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2002: Los Gerrit; Yang Fei; Samimi Goli; Manorek Gerald; Guerorguieva Ivelina M; Howell Stephan; van Erp Nielka; Breaux James K
Using mRNA expression profiling to determine anticancer drug efficacy.
Cytometry 2002;47(1):66-71.
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2001: Johnsson A; Byrne P; de Bruin R; Weiner D; Wong J; Los G
Identification of gene clusters differentially expressed during the cellular injury responses (CIR) to cisplatin.
British journal of cancer 2001;85(8):1206-10.
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2001: Onoda N; Nehmi A; Weiner D; Mujumdar S; Christen R; Los G
Nicotine affects the signaling of the death pathway, reducing the response of head and neck cancer cell lines to DNA damaging agents.
Head & neck 2001;23(10):860-70.
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2001: Lin X; Gately D P; Hom D; Mishima M; Los G; Howell S B
Quantification of tumor cell injury in vitro and in vivo using expression of green fluorescent protein under the control of the GADD153 promoter.
International journal of cancer. Journal international du cancer 2001;91(4):555-62.
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2000: Johnsson A; Zeelenberg I; Min Y; Hilinski J; Berry C; Howell S B; Los G
Identification of genes differentially expressed in association with acquired cisplatin resistance.
British journal of cancer 2000;83(8):1047-54.
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2000: de las Alas M M; Christen R D; Gately D P; Weiner D E; Benbatoul K; Kirmani S; D'Agostino H R; Plaxe S C; Darrah D; McClay E F; Aebi S; Howell S B; Los G
Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel.
Cancer chemotherapy and pharmacology 2000;45(5):381-8.
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1999: Bigio I J; Mourant J R; Los G
Noninvasive, in-situ measurement of drug concentrations in tissue using optical spectroscopy.
Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 1999;6(1):P173-5.
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1999: Los G; Benbatoul K; Gately D P; Barton R; Christen R; Robbins K T; Vicario D; Kirmani S; Orloff L A; Weisman R; Howell S B
Quantitation of the change in GADD153 messenger RNA level as a molecular marker of tumor response in head and neck cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1610-8.
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1999: Mourant J R; Johnson T M; Los G; Bigio I J
Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements.
Physics in medicine and biology 1999;44(5):1397-417.
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1999: Aebi S; Schnider T W; Los G; Heath D D; Darrah D; Kirmani S; McClay E F; D'Agostino H; Plaxe S C; Fink D; De las Alas M M; Howell S B; Christen R D
A phase II/pharmacokinetic trial of high-dose progesterone in combination with paclitaxel.
Cancer chemotherapy and pharmacology 1999;44(3):259-65.
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1999: Johnsson A; Strand C; Los G
Expression of GADD153 in tumor cells and stromal cells from xenografted tumors in nude mice treated with cisplatin: correlations with cisplatin-DNA adducts.
Cancer chemotherapy and pharmacology 1999;43(4):348-52.
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1998: de las Alas M M; de Bruin R A; Ten Eyck L; Los G; Howell S B
Prediction-based threading of the hMSH2 DNA mismatch repair protein.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998;12(9):653-63.
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1998: Weisman R A; Christen R; Los G; Jones V; Kerber C; Seagren S; Glassmeyer S; Orloff L A; Wong W; Kirmani S; Howell S
Phase I trial of retinoic acid and cis-platinum for advanced squamous cell cancer of the head and neck based on experimental evidence of drug synergism.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1998;118(5):597-602.
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1997: Aebi S; Kröning R; Cenni B; Sharma A; Fink D; Los G; Weisman R; Howell S B; Christen R D
all-trans retinoic acid enhances cisplatin-induced apoptosis in human ovarian adenocarcinoma and in squamous head and neck cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(11):2033-8.
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1997: de las Alas M M; Aebi S; Fink D; Howell S B; Los G
Loss of DNA mismatch repair: effects on the rate of mutation to drug resistance.
Journal of the National Cancer Institute 1997;89(20):1537-41.
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1996: Hettinga J V; Lemstra W; Meijer C; Los G; de Vries E G; Konings A W; Kampinga H H
Heat-shock protein expression in cisplatin-sensitive and -resistant human tumor cells.
International journal of cancer. Journal international du cancer 1996;67(6):800-7.
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1996: Robbins K T; Fontanesi J; Wong F S; Vicario D; Seagren S; Kumar P; Weisman R; Pellitteri P; Thomas J R; Flick P; Palmer R; Weir A; Kerber C; Murry T; Ferguson R; Los G; Orloff L; Howell S B
A novel organ preservation protocol for advanced carcinoma of the larynx and pharynx.
Archives of otolaryngology--head & neck surgery 1996;122(8):853-7.
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1996: Los G
Platinum dose-intensity.
The Journal of infusional chemotherapy 1996;6(2):64-8.
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1995: Kröning R; Jones J A; Hom D K; Chuang C C; Sanga R; Los G; Howell S B; Christen R D
Enhancement of drug sensitivity of human malignancies by epidermal growth factor.
British journal of cancer 1995;72(3):615-9.
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1995: Nakata B; Albright K D; Barton R M; Howell S B; Los G
Synergistic interaction between cisplatin and tamoxifen delays the emergence of cisplatin resistance in head and neck cancer cell lines.
Cancer chemotherapy and pharmacology 1995;35(6):511-8.
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1995: Los G; Blommaert f A; Barton R; Heath D D; den Engelse L; Hanchett C; Vicario D; Weisman R; Robbins K T; Howell S B
Selective intra-arterial infusion of high-dose cisplatin in patients with advanced head and neck cancer results in high tumor platinum concentrations and cisplatin-DNA adduct formation.
Cancer chemotherapy and pharmacology 1995;37(1-2):150-4.
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1994: Gately D P; Jones J A; Christen R; Barton R M; Los G; Howell S B
Induction of the growth arrest and DNA damage-inducible gene GADD153 by cisplatin in vitro and in vivo.
British journal of cancer 1994;70(6):1102-6.
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1994: Robbins K T; Vicario D; Seagren S; Weisman R; Pellitteri P; Kerber C; Orloff L; Los G; Howell S B
A targeted supradose cisplatin chemoradiation protocol for advanced head and neck cancer.
American journal of surgery 1994;168(5):419-22.
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1994: Robbins K T; Storniolo A M; Kerber C; Vicario D; Seagren S; Shea M; Hanchett C; Los G; Howell S B
Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(10):2113-20.
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1994: Christen R D; Isonishi S; Jones J A; Jekunen A P; Hom D K; Kröning R; Gately D P; Thiebaut F B; Los G; Howell S B
Signaling and drug sensitivity.
Cancer metastasis reviews 1994;13(2):175-89.
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1994: Los G; Muggia F M
Platinum resistance. Experimental and clinical status.
Hematology/oncology clinics of North America 1994;8(2):411-29.
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1994: Los G; van Vugt M J; Pinedo H M
Response of peritoneal solid tumours after intraperitoneal chemohyperthermia treatment with cisplatin or carboplatin.
British journal of cancer 1994;69(2):235-41.
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1994: Oldenburg J; Begg A C; van Vugt M J; Ruevekamp M; Schornagel J H; Pinedo H M; Los G
Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro.
Cancer research 1994;54(2):487-93.
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1993: Los G; van Vugt M J; den Engelse L; Pinedo H M
Effects of temperature on the interaction of cisplatin and carboplatin with cellular DNA.
Biochemical pharmacology 1993;46(7):1229-37.
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1993: Muggia F M; Los G
Platinum resistance: laboratory findings and clinical implications.
Stem cells (Dayton, Ohio) 1993;11(3):182-93.
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1993: Vermeulen N P; Baldew G S; Los G; McVie J G; De Goeij J J
Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):30-6.
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1993: Los G; Tuyt L; van Vugt M; Schornagel J; Pinedo H M
Combination treatment of cis- and carboplatin in cancers restricted to the peritoneal cavity in the rat.
Cancer chemotherapy and pharmacology 1993;32(6):425-33.
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1993: Kerr D J; Los G
Pharmacokinetic principles of locoregional chemotherapy.
Cancer surveys 1993;17():105-22.
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1992: Hodes T J; Underberg W J; Los G; Beijnen J H
Platinum antitumour agents: a review of (bio)analysis.
Pharmaceutisch weekblad. Scientific edition 1992;14(3):61-77.
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1992: Los G; Smals O A; van Vugt M J; van der Vlist M; den Engelse L; McVie J G; Pinedo H M
A rationale for carboplatin treatment and abdominal hyperthermia in cancers restricted to the peritoneal cavity.
Cancer research 1992;52(5):1252-8.
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1992: Sminia P; Los G; Hendriks J J; van Vugt M J; Haveman J; González González D
The influence of hyperthermia on the uptake of cisplatin in the rat cervical spinal cord.
European journal of cancer (Oxford, England : 1990) 1992;28A(6-7):1139-43.
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1991: Los G; Verdegaal E; Noteborn H P; Ruevekamp M; de Graeff A; Meesters E W; ten Bokkel Huinink D; McVie J G
Cellular pharmacokinetics of carboplatin and cisplatin in relation to their cytotoxic action.
Biochemical pharmacology 1991;42(2):357-63.
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1991: Los G; Kop W; Deurloo M J
Antitumour response and nephrotoxicity following intraperitoneal administration of a slow release formulation of cisplatin to rats bearing cancers restricted to the peritoneal cavity.
British journal of cancer 1991;64(1):90-2.
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1991: Los G; Verdegaal E M; Mutsaers P H; McVie J G
Penetration of carboplatin and cisplatin into rat peritoneal tumor nodules after intraperitoneal chemotherapy.
Cancer chemotherapy and pharmacology 1991;28(3):159-65.
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1991: Los G; Sminia P; Wondergem J; Mutsaers P H; Havemen J; ten Bokkel Huinink D; Smals O; Gonzalez-Gonzalez D; McVie J G
Optimisation of intraperitoneal cisplatin therapy with regional hyperthermia in rats.
European journal of cancer (Oxford, England : 1990) 1991;27(4):472-7.
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1990: Baldew G S; McVie J G; van der Valk M A; Los G; de Goeij J J; Vermeulen N P
Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.
Cancer research 1990;50(21):7031-6.
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1990: Los G; Mutsaers P H; Ruevekamp M; McVie J G
The use of oxaliplatin versus cisplatin in intraperitoneal chemotherapy in cancers restricted to the peritoneal cavity in the rat.
Cancer letters 1990;51(2):109-17.
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1990: Los G; Mutsaers P H; Lenglet W J; Baldew G S; McVie J G
Platinum distribution in intraperitoneal tumors after intraperitoneal cisplatin treatment.
Cancer chemotherapy and pharmacology 1990;25(6):389-94.
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1990: Nagel J D; Los G; Begg A C; McVie J G
A new intraperitoneal tumor model in the rat.
Cancer chemotherapy and pharmacology 1990;27(2):121-4.
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1990: Los G; Nagel J D; McVie J G
Anti-tumor effect of cisplatin, carboplatin, mitoxantrone, and doxorubicin on peritoneal tumor growth after intraperitoneal and intravenous chemotherapy: a comparative study.
Selective cancer therapeutics 1990;6(2):73-82.
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1990: Los G; McVie J G
Experimental and clinical status of intraperitoneal chemotherapy.
European journal of cancer (Oxford, England : 1990) 1990;26(6):755-62.
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1989: Los G; Ruevekamp M; Bosnie N; De Graaf P W; McVie J G
Intraperitoneal tumor growth and chemotherapy in a rat model.
European journal of cancer & clinical oncology 1989;25(12):1857-66.
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1989: Vandebriel R J; De Weger R A; Los G; Van Loveren H; Wiegers G J; Oude Weernink P A; Den Otter W
Two specific T cell factors that initiate immune responses in murine allograft systems. A comparison of biologic functions.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(1):66-73.
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1989: Los G; Mutsaers P H; van der Vijgh W J; Baldew G S; de Graaf P W; McVie J G
Direct diffusion of cis-diamminedichloroplatinum(II) in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy.
Cancer research 1989;49(12):3380-4.
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1989: Baldew G S; van den Hamer C J; Los G; Vermeulen N P; de Goeij J J; McVie J G
Selenium-induced protection against cis-diamminedichloroplatinum(II) nephrotoxicity in mice and rats.
Cancer research 1989;49(11):3020-3.
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1989: Van Loveren H; De Weger R A; Garssen J; Los G; Askenase P W
Impairment of allograft tumor immunity by isotype-like suppression of antigen-specific T cell factors.
Transplantation 1989;47(3):504-12.
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1988: Los G; Beijnen J H; Dubbelman R; ten Bokkel Huinink W W; McVie J G
[Ovarian carcinoma: various aspects of intraperitoneal chemotherapy]
Nederlands tijdschrift voor geneeskunde 1988;132(29):1347-50.
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1988: Los G; De Weger R A; Van den Berg D T; Sakkers R; Den Otter W
Macrophage infiltration in tumors and tumor-surrounding tissue: influence of serotonin and sensitized lymphocytes.
Cancer immunology, immunotherapy : CII 1988;26(2):145-52.
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1987: Sijens P E; Bovée W M; Seijkens D; Koole P; Los G; van Rijssel R H
Murine mammary tumor response to hyperthermia and radiotherapy evaluated by in vivo 31P-nuclear magnetic resonance spectroscopy.
Cancer research 1987;47(24 Pt 1):6467-73.
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1987: Los G; De Weger R A; Moberts R M; Van Loveren H; Sakkers R J; Den Otter W
The absence of delayed-type hypersensitivity reactivity in a syngeneic murine tumour system.
Immunology 1987;62(1):89-95.
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1986: Sijens P E; Bovée W M; Seijkens D; Los G; Rutgers D H
In vivo 31P-nuclear magnetic resonance study of the response of a murine mammary tumor to different doses of gamma-radiation.
Cancer research 1986;46(3):1427-32.
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1981: Mesland D A; Los G; Spiele H
Cytochalasin B disrupts the association of filamentous web and plasma membrane in hepatocytes.
Experimental cell research 1981;135(2):431-5.
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