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subash sad

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Fanny Tzelepis; Rafick-Pierre Sekaly; Fabien Agenes; Renu Dudani; Elias K Haddad; Julie Joseph; Susanne MacLean; Stanford L Peng; subash sad
Intrinsic role of FoxO3a in the development of CD8+ T cell memory.
Fanny Tzelepis; Kevin G Young; Ahmed Zafer; Valeria Alcon; Renu Dudani; Ellen S Everson; Komal Gurnani; Lakshmi Krishnan; Holger Rüssmann; subash sad
Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.
Nirmal Robinson; Renu Dudani; Lakshmi Krishnan; Scott McComb; Rebecca Mulligan; subash sad
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.

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All Publications

2013: Fanny Tzelepis; Rafick-Pierre Sekaly; Fabien Agenes; Renu Dudani; Elias K Haddad; Julie Joseph; Susanne MacLean; Stanford L Peng; subash sad
Intrinsic role of FoxO3a in the development of CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1066-75.
2012: Fanny Tzelepis; Kevin G Young; Ahmed Zafer; Valeria Alcon; Renu Dudani; Ellen S Everson; Komal Gurnani; Lakshmi Krishnan; Holger Rüssmann; subash sad
Modulation of antigenic location converts chronic into acute infection by forcing CD8+ T cell recognition.
Cell reports 2012;2(6):1710-21.
2012: Nirmal Robinson; Renu Dudani; Lakshmi Krishnan; Scott McComb; Rebecca Mulligan; subash sad
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium.
Nature immunology 2012;13(10):954-62.
2012: Greg Hussack; Artine Keklikian; Roger MacKenzie; subash sad; Jawaher Alsughayyir; Mehdi Arbabi-Ghahroudi; Pejman Hanifi-Moghaddam; Sheng T Hou; Henk van Faassen; Jamshid Tanha
A V(L) single-domain antibody library shows a high-propensity to yield non-aggregating binders.
Protein engineering, design & selection : PEDS 2012;25(6):313-8.
2012: Felicity Stark; subash sad; Komal Gurnani; Lakshmi Krishnan
Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.
PloS one 2012;7(2):e32211.
2011: Kevin G Young; Renu Dudani; Lakshmi Krishnan; Susanne MacLean; subash sad
CD8+ T cells primed in the periphery provide time-bound immune-surveillance to the central nervous system.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(3):1192-200.
2010: Anindita Chattopadhyay; Nirmal Robinson; Jagdeep K Sandhu; B Brett Finlay; subash sad; Lakshmi Krishnan
Salmonella enterica serovar Typhimurium-induced placental inflammation and not bacterial burden correlates with pathology and fatal maternal disease.
Infection and immunity 2010;78(5):2292-301.
2010: Scott McComb; Rebecca Mulligan; subash sad
Caspase-3 is transiently activated without cell death during early antigen driven expansion of CD8(+) T cells in vivo.
PloS one 2010;5(12):e15328.
2010: Lakshmi Krishnan; Branka Pejcic-Karapetrovic; Komal Gurnani; Ahmed Zafer; subash sad
Pregnancy does not deter the development of a potent maternal protective CD8+ T-cell acquired immune response against Listeria monocytogenes despite preferential placental colonization.
American journal of reproductive immunology (New York, N.Y. : 1989) 2010;63(1):54-65.
2009: Marsha S Russell; Renu Dudani; Lakshmi Krishnan; subash sad
IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):7710-8.
2009: Christine E Wong; subash sad; Brian K Coombes
Salmonella enterica serovar typhimurium exploits Toll-like receptor signaling during the host-pathogen interaction.
Infection and immunity 2009;77(11):4750-60.
2009: Homam Albaghdadi; Nirmal Robinson; Brett Finlay; Lakshmi Krishnan; subash sad
Selectively reduced intracellular proliferation of Salmonella enterica serovar typhimurium within APCs limits antigen presentation and development of a rapid CD8 T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(6):3778-87.
2009: Felicity Stark; subash sad; Lakshmi Krishnan
Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection.
Cancer research 2009;69(10):4327-34.
2008: Renu Dudani; Kaja Murali-Krishna; Lakshmi Krishnan; subash sad
IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1700-9.
2008: subash sad; Renu Dudani; Komal Gurnani; Marsha Russell; Henk van Faassen; Brett Finlay; Lakshmi Krishnan
Pathogen proliferation governs the magnitude but compromises the function of CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):5853-61.
2008: Renu Dudani; Marsha Russell; Henk van Faassen; Lakshmi Krishnan; subash sad
Mutation in the Fas pathway impairs CD8+ T cell memory.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2933-41.
2007: Branka Pejcic-Karapetrovic; Komal Gurnani; Marsha S Russell; B Brett Finlay; subash sad; Lakshmi Krishnan
Pregnancy impairs the innate immune resistance to Salmonella typhimurium leading to rapid fatal infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6088-96.
2007: Marsha S Russell; Monica Iskandar; Oksana L Mykytczuk; John H E Nash; Lakshmi Krishnan; subash sad
A reduced antigen load in vivo, rather than weak inflammation, causes a substantial delay in CD8+ T cell priming against Mycobacterium bovis (bacillus Calmette-Guérin).
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):211-20.
2007: Lakshmi Krishnan; Komal Gurnani; Chantal J Dicaire; Henk van Faassen; Ahmed Zafer; Carsten J Kirschning; subash sad; G Dennis Sprott
Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(4):2396-406.
2006: Rachel A Luu; Komal Gurnani; Renu Dudani; Rajagopal Kammara; Henk van Faassen; Jean-Claude Sirard; Lakshmi Krishnan; subash sad
Delayed expansion and contraction of CD8+ T cell response during infection with virulent Salmonella typhimurium.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1516-25.
2006: Kimika Saito; Toshiki Yajima; Shino Kumabe; Takehiko Doi; Hisakata Yamada; subash sad; Hao Shen; Yasunobu Yoshikai
Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2496-504.
2006: Florian Winau; Stephan Weber; subash sad; Juana de Diego; Silvia Locatelli Hoops; Bernadette Breiden; Konrad Sandhoff; Volker Brinkmann; Stefan H E Kaufmann; Ulrich E Schaible
Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.
Immunity 2006;24(1):105-17.
2006: Toshiki Yajima; Kazufumi Yoshihara; Kenji Nakazato; Shino Kumabe; Shigeo Koyasu; subash sad; Hao Shen; Hiroyuki Kuwano; Yasunobu Yoshikai
IL-15 regulates CD8+ T cell contraction during primary infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(1):507-15.
2005: Henk van Faassen; Marsha Saldanha; Deanna Gilbertson; Renu Dudani; Lakshmi Krishnan; subash sad
Reducing the stimulation of CD8+ T cells during infection with intracellular bacteria promotes differentiation primarily into a central (CD62LhighCD44high) subset.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(9):5341-50.
2005: Toshiki Yajima; Hitoshi Nishimura; subash sad; Hao Shen; Hiroyuki Kuwano; Yasunobu Yoshikai
A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3590-7.
2004: G Dennis Sprott; Chantal J Dicaire; Komal Gurnani; subash sad; Lakshmi Krishnan
Activation of dendritic cells by liposomes prepared from phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette-Guerin and adjuvant activity in vivo.
Infection and immunity 2004;72(9):5235-46.
2004: Komal Gurnani; Jessica Kennedy; subash sad; G Dennis Sprott; Lakshmi Krishnan
Phosphatidylserine receptor-mediated recognition of archaeosome adjuvant promotes endocytosis and MHC class I cross-presentation of the entrapped antigen by phagosome-to-cytosol transport and classical processing.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(1):566-78.
2004: Henk van Faassen; Renu Dudani; Lakshmi Krishnan; subash sad
Prolonged antigen presentation, APC-, and CD8+ T cell turnover during mycobacterial infection: comparison with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3491-500.
2003: Yvan Chapdelaine; Dean K Smith; Joao Pedras-Vasconcelos; Lakshmi Krishnan; subash sad
Increased CD8+ T cell memory to concurrent infection at the expense of increased erosion of pre-existing memory: the paradoxical role of IL-15.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5454-60.
2003: G Dennis Sprott; subash sad; L Perry Fleming; Chantal J Dicaire; Girishchandra B Patel; Lakshmi Krishnan
Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen.
Archaea (Vancouver, B.C.) 2003;1(3):151-64.
2003: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
Archaeosomes induce enhanced cytotoxic T lymphocyte responses to entrapped soluble protein in the absence of interleukin 12 and protect against tumor challenge.
Cancer research 2003;63(10):2526-34.
2003: subash sad; Lakshmi Krishnan
Maintenance and attrition of T-cell memory.
Critical reviews in immunology 2003;23(1-2):129-47.
2002: Dean K Smith; Renu Dudani; Joao Pedras-Vasconcelos; Yvan Chapdelaine; Henk van Faassen; subash sad
Cross-reactive antigen is required to prevent erosion of established T cell memory and tumor immunity: a heterologous bacterial model of attrition.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(3):1197-206.
2002: Joao Pedras-Vasconcelos; Yvan Chapdelaine; Renu Dudani; Henk van Faassen; Dean K Smith; subash sad
Mycobacterium bovis BCG-infected mice are more susceptible to staphylococcal enterotoxin B-mediated toxic shock than uninfected mice despite reduced in vitro splenocyte responses to superantigens.
Infection and immunity 2002;70(8):4148-57.
2002: Renu Dudani; Yvan Chapdelaine; Henk van Faassen Hv; Dean K Smith; Hao Shen; Lakshmi Krishnan; subash sad
Multiple mechanisms compensate to enhance tumor-protective CD8(+) T cell response in the long-term despite poor CD8(+) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5737-45.
2002: Renu Dudani; Yvan Chapdelaine; Henk van Faassen; Dean K Smith; Hao Shen; Lakshmi Krishnan; subash sad
Preexisting inflammation due to Mycobacterium bovis BCG infection differentially modulates T-cell priming against a replicating or nonreplicating immunogen.
Infection and immunity 2002;70(4):1957-64.
2001: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
The potent adjuvant activity of archaeosomes correlates to the recruitment and activation of macrophages and dendritic cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(3):1885-93.
2000: Lakshmi Krishnan; subash sad; Girishchandra B Patel; G Dennis Sprott
Archaeosomes induce long-term CD8+ cytotoxic T cell response to entrapped soluble protein by the exogenous cytosolic pathway, in the absence of CD4+ T cell help.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5177-85.
2000: T Liu; Z Guo; Q Yang; subash sad; Harold J Jennings
Biochemical engineering of surface alpha 2-8 polysialic acid for immunotargeting tumor cells.
The Journal of biological chemistry 2000;275(42):32832-6.
1999: subash sad; Lakshmi Krishnan
Cytokine deprivation of naive CD8+ T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: a mechanism of self-regulation.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2443-51.
1997: subash sad; L Li; TR Mosmann
Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and Fas cytotoxicity but compromised long term killing of tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):606-13.
1997: L Li; subash sad; D Kägi; TR Mosmann
CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4152-61.
1997: TR Mosmann; L Li; subash sad
Functions of CD8 T-cell subsets secreting different cytokine patterns.
Seminars in immunology 1997;9(2):87-92.
1997: subash sad; Lakshmi Krishnan; R Chris Bleackley; D Kägi; H Hengartner; TR Mosmann
Cytotoxicity and weak CD40 ligand expression of CD8+ type 2 cytotoxic T cells restricts their potential B cell helper activity.
European journal of immunology 1997;27(4):914-22.
1997: TR Mosmann; L Li; H Hengartner; D Kagi; W Fu; subash sad
Differentiation and functions of T cell subsets.
Ciba Foundation symposium 1997;204():148-54; discussion 154-8.
1996: subash sad; D Kägi; TR Mosmann
Perforin and Fas killing by CD8+ T cells limits their cytokine synthesis and proliferation.
The Journal of experimental medicine 1996;184(4):1543-7.
1996: TR Mosmann; subash sad
The expanding universe of T-cell subsets: Th1, Th2 and more.
Immunology today 1996;17(3):138-46.
1995: subash sad; TR Mosmann
Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines.
The Journal of experimental medicine 1995;182(5):1505-15.
1995: L Krishnan; subash sad; Raj Raghupathy
Characterization of an immunosuppressive factor secreted by a human trophoblast-derived choriocarcinoma cell line.
Cellular immunology 1995;162(2):295-308.
1995: subash sad; R Marcotte; TR Mosmann
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines.
Immunity 1995;2(3):271-9.
1995: TR Mosmann; subash sad; L Krishnan; T G Wegmann; L J Guilbert; M Belosevic
Differentiation of subsets of CD4+ and CD8+ T cells.
Ciba Foundation symposium 1995;195():42-50; discussion 50-4.
1994: subash sad; TR Mosmann
Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(8):3514-22.
1993: subash sad; V S Chauhan; K Arunan; Raj Raghupathy
Synthetic gonadotrophin-releasing hormone (GnRH) vaccines incorporating GnRH and synthetic T-helper epitopes.
Vaccine 1993;11(11):1145-50.
1992: subash sad; K Rao; R Arora; GP Talwar; Raj Raghupathy
Bypass of carrier-induced epitope-specific suppression using a T-helper epitope.
Immunology 1992;76(4):599-603.
1991: subash sad; H M Gupta; GP Talwar; Raj Raghupathy
Carrier-induced suppression of the antibody response to a 'self' hapten.
Immunology 1991;74(2):223-7.
1991: subash sad; H M Gupta; GP Talwar; Raj Raghupathy
Hyporesponsiveness to a GnRH vaccine in a non-responder mouse strain is T-cell mediated.
Journal of reproductive immunology 1991;20(2):189-94.
1991: subash sad; GP Talwar; Raj Raghupathy
Influence of the genetic background and carrier protein on the antibody response to GnRH.
Journal of reproductive immunology 1991;19(2):197-207.
1989: GP Talwar; subash sad
Immunotherapy and fertility control by immunization against gonadotrophin-releasing hormone.
Current opinion in immunology 1989;2(5):733-5.