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Claus-Michael Lehr
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40
Schaefer, Ulrich
18
Ehrhardt, Carsten
17
Bakowsky, Udo
11
Lamprecht, Alf
10
Kneuer, Carsten
10
Kostka, Karl-Heinz
10
Kim, Kwang-Jin
9
Baldes, Christiane
8
Taetz, Sebastian
8
Neumann, Dirk
7
Netzlaff, Frank
7
Schäfer, Ulrich
7
Schneider, Marc
6
Sameti, Mohammad
6
Bock, Udo
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All Publications
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2009: Nafee Noha; Schneider Marc; Schaefer Ulrich F; Lehr Claus-Michael
Relevance of the colloidal stability of chitosan/PLGA nanoparticles on their cytotoxicity profile.
International journal of pharmaceutics 2009;381(2):130-9.
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2009: Melero A; Garrigues T M; Alós M; Kostka K H; Lehr C M; Schaefer U F
Nortriptyline for smoking cessation: release and human skin diffusion from patches.
International journal of pharmaceutics 2009;378(1-2):101-7.
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2009: Bur Michael; Henning Andreas; Hein Stephanie; Schneider Marc; Lehr Claus-Michael
Inhalative nanomedicine--opportunities and challenges.
Inhalation toxicology 2009;21 Suppl 1():137-43.
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2009: Taetz Sebastian; Bochot Amélie; Surace Claudio; Arpicco Silvia; Renoir Jack-Michel; Schaefer Ulrich F; Marsaud Véronique; Kerdine-Roemer Saadia; Lehr Claus-Michael; Fattal Elias
Hyaluronic acid-modified DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells.
Oligonucleotides 2009;19(2):103-16.
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2009: Lehr Claus-Michael
Biological barriers and nanomedicine--timely challenges in advanced drug delivery research.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;72(2):287-8.
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2009: Hansen Steffi; Naegel Arne; Heisig Michael; Wittum Gabriel; Neumann Dirk; Kostka Karl-Heinz; Meiers Peter; Lehr Claus-Michael; Schaefer Ulrich F
The role of corneocytes in skin transport revised--a combined computational and experimental approach.
Pharmaceutical research 2009;26(6):1379-97.
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2009: Bur Michael; Rothen-Rutishauser Barbara; Huwer Hanno; Lehr Claus-Michael
A novel cell compatible impingement system to study in vitro drug absorption from dry powder aerosol formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;72(2):350-7.
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2009: Taetz S; Nafee N; Beisner J; Piotrowska K; Baldes C; Mürdter T E; Huwer H; Schneider M; Schaefer U F; Klotz U; Lehr C-M
The influence of chitosan content in cationic chitosan/PLGA nanoparticles on the delivery efficiency of antisense 2'-O-methyl-RNA directed against telomerase in lung cancer cells.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;72(2):358-69.
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2009: Beisner Julia; Dong Meng; Taetz Sebastian; Piotrowska Kamilla; Kleideiter Elke; Friedel Godehard; Schaefer Ulrich; Lehr Claus-Michael; Klotz Ulrich; Mürdter Thomas E
Efficient telomerase inhibition in human non-small cell lung cancer cells by liposomal delivery of 2'-O-methyl-RNA.
Journal of pharmaceutical sciences 2009;98(5):1765-74.
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2009: Meier Katharina; Lehr Claus-Michael; Daum Nicole
Differentiation potential of human pancreatic stem cells for epithelial- and endothelial-like cell types.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2009;191(1):70-82.
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2009: Daum Nicole; Neumeyer Andrea; Wahl Birgit; Bur Michael; Lehr Claus-Michael
In vitro systems for studying epithelial transport of macromolecules.
Methods in molecular biology (Clifton, N.J.) 2009;480():151-64.
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2008: Bur Michael; Lehr Claus-Michael
Pulmonary cell culture models to study the safety and efficacy of innovative aerosol medicines.
Expert opinion on drug delivery 2008;5(6):641-52.
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2008: Taetz S; Mürdter T E; Zapp J; Boettcher S; Baldes C; Kleideiter E; Piotrowska K; Schaefer U F; Klotz U; Lehr C-M
Decomposition of the telomere-targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential.
International journal of pharmaceutics 2008;357(1-2):6-14.
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2008: Melero Ana; Garrigues T M; Almudever P; Villodre A Marti N; Lehr C M; Schäfer U
Nortriptyline hydrochloride skin absorption: development of a transdermal patch.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;69(2):588-96.
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2008: Kaca Monika; Bock Udo; Tawfik Jalal Mohamed; Harms Meike; Hoffmann Christine; Müller-Goymann Christel; Netzlaff Frank; Schäfer Ulrich; Lehr Claus-Michael; Haltner-Ukomadu Eleonore
The physicochemical parameters of marker compounds and vehicles for use in in vitro percutaneous absorption studies.
Alternatives to laboratory animals : ATLA 2008;36(2):189-200.
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2008: Schäfer-Korting Monika; Bock Udo; Diembeck Walter; Düsing Hans-Jürgen; Gamer Armin; Haltner-Ukomadu Eleonore; Hoffmann Christine; Kaca Monika; Kamp Hennicke; Kersen Silke; Kietzmann Manfred; Korting Hans Christian; Krächter Hans-Udo; Lehr Claus-Michael; Liebsch Manfred; Mehling Annette; Müller-Goymann Christel; Netzlaff Frank; Niedorf Frank; Rübbelke Maria K; Schäfer Ulrich; Schmidt Elisabeth; Schreiber Sylvia; Spielmann Horst; Vuia Alexander; Weimer Michaela
The use of reconstructed human epidermis for skin absorption testing: Results of the validation study.
Alternatives to laboratory animals : ATLA 2008;36(2):161-87.
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2008: Becker Ulrich; Ehrhardt Carsten; Schneider Marc; Muys Leon; Gross Dorothea; Eschmann Klaus; Schaefer Ulrich F; Lehr Claus-Michael
A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability.
Alternatives to laboratory animals : ATLA 2008;36(1):33-44.
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2008: Naegel Arne; Hansen Steffi; Neumann Dirk; Lehr Claus-Michael; Schaefer Ulrich F; Wittum Gabriel; Heisig Michael
In-silico model of skin penetration based on experimentally determined input parameters. Part II: mathematical modelling of in-vitro diffusion experiments. Identification of critical input parameters.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):368-79.
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2008: Hansen Steffi; Henning Andreas; Naegel Arne; Heisig Michael; Wittum Gabriel; Neumann Dirk; Kostka Karl-Heinz; Zbytovska Jarmila; Lehr Claus-Michael; Schaefer Ulrich F
In-silico model of skin penetration based on experimentally determined input parameters. Part I: experimental determination of partition and diffusion coefficients.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):352-67.
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2008: Henning A; Schneider M; Bur M; Blank F; Gehr P; Lehr C-M
Embryonic chicken trachea as a new in vitro model for the investigation of mucociliary particle clearance in the airways.
AAPS PharmSciTech 2008;9(2):521-7.
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2008: Henning A; Neumann D; Kostka K-H; Lehr C-M; Schaefer U F
Influence of human skin specimens consisting of different skin layers on the result of in vitro permeation experiments.
Skin pharmacology and physiology 2008;21(2):81-8.
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2007: Nafee Noha; Taetz Sebastian; Schneider Marc; Schaefer Ulrich F; Lehr Claus-Michael
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.
Nanomedicine : nanotechnology, biology, and medicine 2007;3(3):173-83.
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2007: Beck R C R; Pohlmann A R; Hoffmeister C; Gallas M R; Collnot E; Schaefer U F; Guterres S S; Lehr C M
Dexamethasone-loaded nanoparticle-coated microparticles: correlation between in vitro drug release and drug transport across Caco-2 cell monolayers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(1):18-30.
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2007: Weiss Barbara; Schneider Marc; Muys Leon; Taetz Sebastian; Neumann Dirk; Schaefer Ulrich F; Lehr Claus-Michael
Coupling of biotin-(poly(ethylene glycol))amine to poly(D,L-lactide-co-glycolide) nanoparticles for versatile surface modification.
Bioconjugate chemistry 2007;18(4):1087-94.
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2007: Steimer Anne; Franke Helmut; Haltner-Ukomado Eleonore; Laue Michael; Ehrhardt Carsten; Lehr Claus-Michael
Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(3):372-82.
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2007: Collnot Eva-Maria; Baldes Christiane; Wempe Michael F; Kappl Reinhard; Hüttermann Jürgen; Hyatt John A; Edgar Kevin J; Schaefer Ulrich F; Lehr Claus-Michael
Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: influence on ATPase activity and membrane fluidity.
Molecular pharmaceutics 2007;4(3):465-74.
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2007: Lademann Juergen; Richter Heike; Teichmann Alexa; Otberg Nina; Blume-Peytavi Ulrike; Luengo Javiana; Weiss Barbara; Schaefer Ulrich F; Lehr Claus-Michael; Wepf Roger; Sterry Wolfram
Nanoparticles--an efficient carrier for drug delivery into the hair follicles.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(2):159-64.
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2007: Motz Stephan A; Schaefer Ulrich F; Balbach Stefan; Eichinger Thomas; Lehr Claus-Michael
Permeability assessment for solid oral drug formulations based on Caco-2 monolayer in combination with a flow through dissolution cell.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(2):286-95.
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2007: Becker Ulrich; Ehrhardt Carsten; Daum Nicole; Baldes Christiane; Schaefer Ulrich F; Ruprecht Klaus W; Kim Kwang-Jin; Lehr Claus-Michael
Expression of ABC-transporters in human corneal tissue and the transformed cell line, HCE-T.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2007;23(2):172-81.
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2007: Zurdo Schroeder Ines; Franke Patrick; Schaefer Ulrich F; Lehr Claus-Michael
Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(2):196-203.
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2007: Endter Sibylle; Becker Ulrich; Daum Nicole; Huwer Hanno; Lehr Claus-Michael; Gumbleton Mark; Ehrhardt Carsten
P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers.
Cell and tissue research 2007;328(1):77-84.
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2007: Netzlaff Frank; Kaca Monika; Bock Udo; Haltner-Ukomadu Eleonore; Meiers Peter; Lehr Claus-Michael; Schaefer Ulrich F
Permeability of the reconstructed human epidermis model Episkin in comparison to various human skin preparations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;66(1):127-34.
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2007: Motz Stephan A; Klimundová Jana; Schaefer Ulrich F; Balbach Stefan; Eichinger Thomas; Solich Petr; Lehr Claus-Michael
Automated measurement of permeation and dissolution of propranolol HCl tablets using sequential injection analysis.
Analytica chimica acta 2007;581(1):174-80.
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2007: Zurdo Schroeder Ines; Franke Patrick; Schaefer Ulrich F; Lehr Claus-Michael
Development and characterization of film forming polymeric solutions for skin drug delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;65(1):111-21.
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2007: Betz Thomas; Bakowsky Udo; Müller Michael R; Lehr Claus-Michael; Bernhardt Ingolf
Conformational change of membrane proteins leads to shape changes of red blood cells.
Bioelectrochemistry (Amsterdam, Netherlands) 2007;70(1):122-6.
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2006: Anabousi Samah; Bakowsky Udo; Schneider Marc; Huwer Hanno; Lehr Claus-Michael; Ehrhardt Carsten
In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(5):367-74.
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2006: Sigurdsson Hakon H; Loftsson Thorsteinn; Lehr Claus-Michael
Assessment of mucoadhesion by a resonant mirror biosensor.
International journal of pharmaceutics 2006;325(1-2):75-81.
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2006: Netzlaff Frank; Schaefer Unlrich F; Lehr Claus-Michael; Meiers Peter; Stahl Jessica; Kietzmann Manfred; Niedorf Frank
Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments.
Alternatives to laboratory animals : ATLA 2006;34(5):499-513.
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2006: Stracke Frank; Weiss Barbara; Lehr Claus-Michael; König Karsten; Schaefer Ulrich F; Schneider Marc
Multiphoton microscopy for the investigation of dermal penetration of nanoparticle-borne drugs.
The Journal of investigative dermatology 2006;126(10):2224-33.
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2006: Löhbach Christoph; Neumann Dirk; Lehr Claus-Michael; Lamprecht Alf
Human vascular endothelial cells in primary cell culture for the evaluation of nanoparticle bioadhesion.
Journal of nanoscience and nanotechnology 2006;6(9-10):3303-9.
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2006: Weiss Barbara; Schaefer Ulrich F; Zapp Josef; Lamprecht Alf; Stallmach Andreas; Lehr Claus-Michael
Nanoparticles made of fluorescence-labelled Poly(L-lactide-co-glycolide): preparation, stability, and biocompatibility.
Journal of nanoscience and nanotechnology 2006;6(9-10):3048-56.
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2006: Anabousi Samah; Kleemann Elke; Bakowsky Udo; Kissel Thomas; Schmehl Thomas; Gessler Tobias; Seeger Werner; Lehr Claus-Michael; Ehrhardt Carsten
Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant.
Journal of nanoscience and nanotechnology 2006;6(9-10):3010-6.
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2006: Kneuer Carsten; Ehrhardt Carsten; Bakowsky Heike; Kumar M N V Ravi; Oberle Volker; Lehr Claus M; Hoekstra Dick; Bakowsky Udo
The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: a comparative study.
Journal of nanoscience and nanotechnology 2006;6(9-10):2776-82.
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2006: Steimer Anne; Laue Michael; Franke Helmut; Haltner-Ukomado Eleonore; Lehr Claus-Michael
Porcine alveolar epithelial cells in primary culture: morphological, bioelectrical and immunocytochemical characterization.
Pharmaceutical research 2006;23(9):2078-93.
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2006: Schäfer-Korting Monika; Bock Udo; Gamer Armin; Haberland Annekathrin; Haltner-Ukomadu Eleonore; Kaca Monika; Kamp Hennicke; Kietzmann Manfred; Korting Hans Christian; Krächter Hans-Udo; Lehr Claus-Michael; Liebsch Manfred; Mehling Annette; Netzlaff Frank; Niedorf Frank; Rübbelke Maria K; Schäfer Ulrich; Schmidt Elisabeth; Schreiber Sylvia; Schröder Klaus-Rudolf; Spielmann Horst; Vuia Alexander
Reconstructed human epidermis for skin absorption testing: results of the German prevalidation study.
Alternatives to laboratory animals : ATLA 2006;34(3):283-94.
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2006: Bur Michael; Huwer Hanno; Lehr Claus-Michael; Hagen Nina; Guldbrandt Mette; Kim Kwang-Jin; Ehrhardt Carsten
Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;28(3):196-203.
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2006: Taetz S; Baldes C; Mürdter T E; Kleideiter E; Piotrowska K; Bock U; Haltner-Ukomadu E; Mueller J; Huwer H; Schaefer U F; Klotz U; Lehr C-M
Biopharmaceutical characterization of the telomerase inhibitor BRACO19.
Pharmaceutical research 2006;23(5):1031-7.
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2006: Netzlaff Frank; Kostka Karl-Heinz; Lehr Claus-Michael; Schaefer Ulrich F
TEWL measurements as a routine method for evaluating the integrity of epidermis sheets in static Franz type diffusion cells in vitro. Limitations shown by transport data testing.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2006;63(1):44-50.
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2006: Collnot Eva-Maria; Baldes Christiane; Wempe Michael F; Hyatt John; Navarro Lisa; Edgar Kevin J; Schaefer Ulrich Friedrich; Lehr Claus-Michael
Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):35-40.
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2006: Ehrhardt Carsten; Collnot Eva-Maria; Baldes Christiane; Becker Ulrich; Laue Michael; Kim Kwang-Jin; Lehr Claus-Michael
Towards an in vitro model of cystic fibrosis small airway epithelium: characterisation of the human bronchial epithelial cell line CFBE41o-.
Cell and tissue research 2006;323(3):405-15.
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2006: Baldes C; Koenig P; Neumann D; Lenhof H-P; Kohlbacher O; Lehr C-M
Development of a fluorescence-based assay for screening of modulators of human organic anion transporter 1B3 (OATP1B3).
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2006;62(1):39-43.
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2006: Lehr Claus-Michael; Bur Michael; Schaefer Ulrich F
Cell culture models of the air-blood barrier for the evaluation of aerosol medicines.
ALTEX : Alternativen zu Tierexperimenten 2006;23 Suppl():259-64.
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2006: Luengo J; Weiss B; Schneider M; Ehlers A; Stracke F; König K; Kostka K-H; Lehr C-M; Schaefer U F
Influence of nanoencapsulation on human skin transport of flufenamic acid.
Skin pharmacology and physiology 2006;19(4):190-7.
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2005: Piotrowska Kamilla; Kleideiter Elke; Mürdter Thomas E; Taetz Sebastian; Baldes Christiane; Schaefer Ulrich; Lehr Claus-Michael; Klotz Ulrich
Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors.
Laboratory investigation; a journal of technical methods and pathology 2005;85(12):1565-9.
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2005: Anabousi Samah; Laue Michael; Lehr Claus-Michael; Bakowsky Udo; Ehrhardt Carsten
Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;60(2):295-303.
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2005: Netzlaff Frank; Lehr C-M; Wertz P W; Schaefer U F
The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;60(2):167-78.
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2005: Lehr C M
Cell culture models and nanobiotechnology--contemporary topics in advanced drug delivery research.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;60(2):v-vi.
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2005: Becker Ulrich; Ehrhardt Carsten; Schaefer Ulrich F; Gukasyan Hovhannes J; Kim Kwang-Jin; Lee Vincent H L; Lehr Claus-Michael
Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2005;21(3):210-6.
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2005: Yu Fayou; Mücklich Frank; Li Ping; Shen Hao; Mathur Sanjay; Lehr Claus-Michael; Bakowsky Udo
In vitro cell response to a polymer surface micropatterned by laser interference lithography.
Biomacromolecules 2005;6(3):1160-7.
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2005: Yu Fayou; Li Ping; Shen Hao; Mathur Sanjay; Lehr Claus-Michael; Bakowsky Udo; Mücklich Frank
Laser interference lithography as a new and efficient technique for micropatterning of biopolymer surface.
Biomaterials 2005;26(15):2307-12.
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2005: Nakamura Takayuki; Abu-Dahab Rana; Menger Michael D; Schäfer Ulrich; Vollmar Brigitte; Wada Hiromi; Lehr Claus-Michael; Schäfers Hans-Joachim
Depletion of alveolar macrophages by clodronate-liposomes aggravates ischemia-reperfusion injury of the lung.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005;24(1):38-45.
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2005: Kim Kwang-Jin; Borok Zea; Ehrhardt Carsten; Willis Brigham C; Lehr Claus-Michael; Crandall Edward D
Estimation of paracellular conductance of primary rat alveolar epithelial cell monolayers.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(1):138-43.
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2005: Haas Jochen; Ravi Kumar M N V; Borchard Gerrit; Bakowsky Udo; Lehr Claus-Michael
Preparation and characterization of chitosan and trimethyl-chitosan-modified poly-(epsilon-caprolactone) nanoparticles as DNA carriers.
AAPS PharmSciTech 2005;6(1):E22-30.
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2005: Steimer A; Haltner E; Lehr C-M
Cell culture models of the respiratory tract relevant to pulmonary drug delivery.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2005;18(2):137-82.
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2005: Ehrhardt Carsten; Kneuer Carsten; Bies Christiane; Lehr Claus-Michael; Kim Kwang-Jin; Bakowsky Udo
Salbutamol is actively absorbed across human bronchial epithelial cell layers.
Pulmonary pharmacology & therapeutics 2005;18(3):165-70.
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2005: Ehrhardt Carsten; Kim Kwang-Jin; Lehr Claus-Michael
Isolation and culture of human alveolar epithelial cells.
Methods in molecular medicine 2005;107():207-16.
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2004: Kumar M N V Ravi; Mohapatra S S; Kong X; Jena P K; Bakowsky U; Lehr C M
Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents.
Journal of nanoscience and nanotechnology 2004;4(8):990-4.
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2004: Ueda Mitsuhiro; Fuchs Sabine; Nakamura Takayuki; Schäfer Ulrich F; Lehr Claus M; Menger Michael D; Schäfers Hans-Joachim
Reoxygenation results in cell death of human alveolar epithelial cells.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2004;23(10):1198-204.
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2004: Ravi Kumar M N V; Sameti M; Mohapatra S S; Kong X; Lockey R F; Bakowsky U; Lindenblatt G; Schmidt H; Lehr C M
Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo.
Journal of nanoscience and nanotechnology 2004;4(7):876-81.
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2004: Tabatt Kerstin; Kneuer Carsten; Sameti Mohammad; Olbrich Carsten; Müller Rainer H; Lehr Claus-Michael; Bakowsky Udo
Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(2):321-32.
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2004: Ravi Kumar M N V; Bakowsky U; Lehr C M
Preparation and characterization of cationic PLGA nanospheres as DNA carriers.
Biomaterials 2004;25(10):1771-7.
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2004: Tabatt Kerstin; Sameti Mohammad; Olbrich Carsten; Müller Rainer H; Lehr Claus-Michael
Effect of cationic lipid and matrix lipid composition on solid lipid nanoparticle-mediated gene transfer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;57(2):155-62.
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2004: Neumann Dirk; Lehr Claus-Michael; Lenhof Hans-Peter; Kohlbacher Oliver
Computational modeling of the sugar-lectin interaction.
Advanced drug delivery reviews 2004;56(4):437-57.
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2004: Bies Christiane; Lehr Claus-Michael; Woodley John F
Lectin-mediated drug targeting: history and applications.
Advanced drug delivery reviews 2004;56(4):425-35.
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2004: Lehr Claus-Michael; Gabor Franz
Lectins and glycoconjugates in drug delivery and targeting.
Advanced drug delivery reviews 2004;56(4):419-20.
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2003: Sameti M; Bohr G; Ravi Kumar M N V; Kneuer C; Bakowsky U; Nacken M; Schmidt H; Lehr C-M
Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery.
International journal of pharmaceutics 2003;266(1-2):51-60.
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2003: Li Ping; Bakowsky Udo; Yu Fayou; Loehbach Christoph; Muecklich Frank; Lehr Claus-Michael
Laser ablation patterning by interference induces directional cell growth.
IEEE transactions on nanobioscience 2003;2(3):138-45.
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2003: Fiegel Jennifer; Ehrhardt Carsten; Schaefer Ulrich Friedrich; Lehr Claus-Michael; Hanes Justin
Large porous particle impingement on lung epithelial cell monolayers--toward improved particle characterization in the lung.
Pharmaceutical research 2003;20(5):788-96.
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2003: Ehrhardt Carsten; Kneuer Carsten; Laue Michael; Schaefer Ulrich Friedrich; Kim Kwang-Jin; Lehr Claus-Michael
16HBE14o- human bronchial epithelial cell layers express P-glycoprotein, lung resistance-related protein, and caveolin-1.
Pharmaceutical research 2003;20(4):545-51.
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2003: Wagner Heike; Kostka Karl Heinz; Lehr Claus Michael; Schaefer Ulrich F
pH profiles in human skin: influence of two in vitro test systems for drug delivery testing.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2003;55(1):57-65.
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2003: Ruppert Clemens; Markart Philipp; Schmidt Reinhold; Grimminger Friedrich; Seeger Werner; Lehr Claus-Michael; Günther Andreas
Chemical crosslinking of urokinase to pulmonary surfactant protein B for targeting alveolar fibrin.
Thrombosis and haemostasis 2003;89(1):53-64.
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2003: Fuchs Sabine; Hollins Andrew John; Laue Michael; Schaefer Ulrich Friedrich; Roemer Klaus; Gumbleton Mark; Lehr Claus-Michael
Differentiation of human alveolar epithelial cells in primary culture: morphological characterization and synthesis of caveolin-1 and surfactant protein-C.
Cell and tissue research 2003;311(1):31-45.
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2002: Wirth M; Kneuer C; Lehr C M; Gabor F
Lectin-mediated drug delivery: discrimination between cytoadhesion and cytoinvasion and evidence for lysosomal accumulation of wheat germ agglutinin in the Caco-2 model.
Journal of drug targeting 2002;10(6):439-48.
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2002: Wagner Heike; Kostka Karl-Heinz; Lehr Claus-Michael; Schaefer Ulrich F
Correlation between stratum corneum/water-partition coefficient and amounts of flufenamic acid penetrated into the stratum corneum.
Journal of pharmaceutical sciences 2002;91(8):1915-21.
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2002: Ruppert Clemens; Schmidt Reinhold; Grimminger Friedrich; Suzuki Yasuhiro; Seeger Werner; Lehr Claus-Michael; Günther Andreas
Chemical coupling of a monoclonal antisurfactant protein-B antibody to human urokinase for targeting surfactant-incorporating alveolar fibrin.
Bioconjugate chemistry 2002;13(4):804-11.
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2002: Ehrhardt Carsten; Kneuer Carsten; Fiegel Jennifer; Hanes Justin; Schaefer Ulrich Friedrich; Kim Kwang-Jin; Lehr Claus-Michael
Influence of apical fluid volume on the development of functional intercellular junctions in the human epithelial cell line 16HBE14o-: implications for the use of this cell line as an in vitro model for bronchial drug absorption studies.
Cell and tissue research 2002;308(3):391-400.
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2002: Haas Jochen; Lehr Claus-Michael
Developments in the area of bioadhesive drug delivery systems.
Expert opinion on biological therapy 2002;2(3):287-98.
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2002: Wagner Heike; Kostka Karl-Heinz; Lehr Claus-Michael; Schaefer Ulrich F
Human skin penetration of flufenamic acid: in vivo/in vitro correlation (deeper skin layers) for skin samples from the same subject.
The Journal of investigative dermatology 2002;118(3):540-4.
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2002: Neumann Dirk; Kohlbacher Oliver; Lenhof Hans-Peter; Lehr Claus-Michael
Lectin-sugar interaction. Calculated versus experimental binding energies.
European journal of biochemistry / FEBS 2002;269(5):1518-24.
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2002: Ehrhardt C; Fiegel J; Fuchs S; Abu-Dahab R; Schaefer U F; Hanes J; Lehr C-M
Drug absorption by the respiratory mucosa: cell culture models and particulate drug carriers.
Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 2002;15(2):131-9.
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2001: Voshaar T; App E M; Berdel D; Buhl R; Fischer J; Gessler T; Haidl P; Heyder J; Köhler D; Kohlhäufl M; Lehr C M; Lindemann H; Matthys H; Meyer T; Olschewski H; Paul K D; Rabe K; Raschke F; Scheuch G; Schmehl T; Schultze-Werninghaus G; Ukena D; Worth H;
[Recommendations for the choice of inhalatory systems for drug prescription]
Pneumologie (Stuttgart, Germany) 2001;55(12):579-86.
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2001: Olbrich C; Bakowsky U; Lehr C M; Müller R H; Kneuer C
Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA.
Journal of controlled release : official journal of the Controlled Release Society 2001;77(3):345-55.
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2001: Lamprecht A; Ubrich N; Yamamoto H; Schäfer U; Takeuchi H; Maincent P; Kawashima Y; Lehr C M
Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease.
The Journal of pharmacology and experimental therapeutics 2001;299(2):775-81.
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2001: Wagner H; Kostka K H; Lehr C M; Schaefer U F
Interrelation of permeation and penetration parameters obtained from in vitro experiments with human skin and skin equivalents.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):283-95.
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2001: Abu-Dahab R; Schäfer U F; Lehr C M
Lectin-functionalized liposomes for pulmonary drug delivery: effect of nebulization on stability and bioadhesion.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;14(1):37-46.
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2001: Lizio R; Marx D; Nolte T; Lehr C M; Sarlikiotis A W; Borchard G; Jahn W; Klenner T
Development of a new aerosol delivery system for systemic pulmonary delivery in anaesthetized and orotracheal intubated rats.
Laboratory animals 2001;35(3):261-70.
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2001: Lizio R; Westhof A; Lehr C M; Klenner T
Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery.
Laboratory animals 2001;35(3):257-60.
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2001: Lamprecht A; Schäfer U; Lehr C M
Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa.
Pharmaceutical research 2001;18(6):788-93.
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2001: Lizio R; Klenner T; Sarlikiotis A W; Romeis P; Marx D; Nolte T; Jahn W; Borchard G; Lehr C M
Systemic delivery of cetrorelix to rats by a new aerosol delivery system.
Pharmaceutical research 2001;18(6):771-9.
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2001: Lamprecht A; Schäfer U; Lehr C M
Influences of process parameters on preparation of microparticle used as a carrier system for omega - 3 unsaturated fatty acid ethyl esters used in supplementary nutrition.
Journal of microencapsulation 2001;18(3):347-57.
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2001: Lamprecht A; Ubrich N; Yamamoto H; Schäfer U; Takeuchi H; Lehr C M; Maincent P; Kawashima Y
Design of rolipram-loaded nanoparticles: comparison of two preparation methods.
Journal of controlled release : official journal of the Controlled Release Society 2001;71(3):297-306.
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2001: Lizio R; Damm M; Sarlikiotis A W; Bauer H H; Lehr C M
Low-temperature micronization of a peptide drug in fluid propellant: case study cetrorelix.
AAPS PharmSciTech 2001;2(3):E12.
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2001: Brück A; Abu-Dahab R; Borchard G; Schäfer U F; Lehr C M
Lectin-functionalized liposomes for pulmonary drug delivery: interaction with human alveolar epithelial cells.
Journal of drug targeting 2001;9(4):241-51.
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2001: Gindorf C; Steimer A; Lehr C M; Bock U; Schmitz S; Haltner E
[Marker transport across biological barriers in vitro: comparison of cell culture models for the gastrointestinal barrier, the blood-brain barrier and the alveolar epithelium of the lung]
ALTEX : Alternativen zu Tierexperimenten 2001;18(3):155-64.
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2001: Zghoul N; Fuchs R; Lehr C M; Schaefer U F
Reconstructed skin equivalents for assessing percutaneous drug absorption from pharmaceutical formulations.
ALTEX : Alternativen zu Tierexperimenten 2001;18(2):103-6.
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2001: Lehr C M
[In vitro models of intestinal and alveolar epithelium cultures in pharmaceutical research]
ALTEX : Alternativen zu Tierexperimenten 2001;18(1):59-63.
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2000: Wagner H; Kostka K H; Lehr C M; Schaefer U F
Drug distribution in human skin using two different in vitro test systems: comparison with in vivo data.
Pharmaceutical research 2000;17(12):1475-81.
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2000: Gershanik T; Haltner E; Lehr C M; Benita S
Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity.
International journal of pharmaceutics 2000;211(1-2):29-36.
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2000: Lamprecht A; Rodero Torres H; Schäfer U; Lehr C M
Biodegradable microparticles as a two-drug controlled release formulation: a potential treatment of inflammatory bowel disease.
Journal of controlled release : official journal of the Controlled Release Society 2000;69(3):445-54.
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2000: Kneuer C; Sameti M; Bakowsky U; Schiestel T; Schirra H; Schmidt H; Lehr C M
A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro.
Bioconjugate chemistry 2000;11(6):926-32.
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2000: Kneuer C; Sameti M; Haltner E G; Schiestel T; Schirra H; Schmidt H; Lehr C M
Silica nanoparticles modified with aminosilanes as carriers for plasmid DNA.
International journal of pharmaceutics 2000;196(2):257-61.
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2000: Lamprecht A; Schäfer U F; Lehr C M
Visualization and quantification of polymer distribution in microcapsules by confocal laser scanning microscopy (CLSM).
International journal of pharmaceutics 2000;196(2):223-6.
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2000: Lamprecht A; Ubrich N; Hombreiro Pérez M; Lehr C; Hoffman M; Maincent P
Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique.
International journal of pharmaceutics 2000;196(2):177-82.
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2000: Lehr C M
Lectin-mediated drug delivery: the second generation of bioadhesives.
Journal of controlled release : official journal of the Controlled Release Society 2000;65(1-2):19-29.
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2000: Lamprecht A; Schäfer U F; Lehr C
Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2000;49(1):1-9.
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2000: Lizio R; Klenner T; Borchard G; Romeis P; Sarlikiotis A W; Reissmann T; Lehr C M
Systemic delivery of the GnRH antagonist cetrorelix by intratracheal instillation in anesthetized rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2000;9(3):253-8.
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2000: Lamprecht A; Schäfer U; Lehr C M
Structural analysis of microparticles by confocal laser scanning microscopy.
AAPS PharmSciTech 2000;1(3):E17.
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1999: Shen J; Elbert K J; Yamashita F; Lehr C M; Kim K J; Lee V H
Organic cation transport in rabbit alveolar epithelial cell monolayers.
Pharmaceutical research 1999;16(8):1280-7.
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1999: Lamprecht A; Ubrich N; Hombreiro Pérez M; Lehr C; Hoffman M; Maincent P
Biodegradable monodispersed nanoparticles prepared by pressure homogenization-emulsification.
International journal of pharmaceutics 1999;184(1):97-105.
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1999: Elbert K J; Schäfer U F; Schäfers H J; Kim K J; Lee V H; Lehr C M
Monolayers of human alveolar epithelial cells in primary culture for pulmonary absorption and transport studies.
Pharmaceutical research 1999;16(5):601-8.
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1998: Bock U; Kolac C; Borchard G; Koch K; Fuchs R; Streichhan P; Lehr C M
Transport of proteolytic enzymes across Caco-2 cell monolayers.
Pharmaceutical research 1998;15(9):1393-400.
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1997: Sattler S; Schaefer U; Schneider W; Hoelzl J; Lehr C M
Binding, uptake, and transport of hypericin by Caco-2 cell monolayers.
Journal of pharmaceutical sciences 1997;86(10):1120-6.
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1997: Christmann V; Rosenberg J; Seega J; Lehr C M
Simultaneous in vivo visualization and localization of solid oral dosage forms in the rat gastrointestinal tract by magnetic resonance imaging (MRI).
Pharmaceutical research 1997;14(8):1066-72.
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1997: Becker H; Hartmann R; Kallmayer H J; Lehr C M; Loth H; Maurer H H
[Pharmacy at the Univeristy of the Saarlands]
Pharmazie in unserer Zeit 1997;26(4):199-201.
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1996: Lehr C M
From sticky stuff to sweet receptors--achievements, limits and novel approaches to bioadhesion.
European journal of drug metabolism and pharmacokinetics 1996;21(2):139-48.
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1995: Luessen H L; Verhoef J C; Borchard G; Lehr C M; de Boer A G; Junginger H E
Mucoadhesive polymers in peroral peptide drug delivery. II. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin.
Pharmaceutical research 1995;12(9):1293-8.
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1994: Lehr C M; Lee Y H; Lee V H
Improved ocular penetration of gentamicin by mucoadhesive polymer polycarbophil in the pigmented rabbit.
Investigative ophthalmology & visual science 1994;35(6):2809-14.
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1994: Lehr C M
Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract.
Critical reviews in therapeutic drug carrier systems 1994;11(2-3):119-60.
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1993: Lehr C M; Lee V H
Binding and transport of some bioadhesive plant lectins across Caco-2 cell monolayers.
Pharmaceutical research 1993;10(12):1796-9.
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1992: Lehr C M; Bouwstra J A; Kok W; De Boer A G; Tukker J J; Verhoef J C; Breimer D D; Junginger H E
Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat.
The Journal of pharmacy and pharmacology 1992;44(5):402-7.
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1992: Lehr C M; Bouwstra J A; Kok W; Noach A B; de Boer A G; Junginger H E
Bioadhesion by means of specific binding of tomato lectin.
Pharmaceutical research 1992;9(4):547-53.
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1992: Lehr C M; Bouwstra J A; Boddé H E; Junginger H E
A surface energy analysis of mucoadhesion: contact angle measurements on polycarbophil and pig intestinal mucosa in physiologically relevant fluids.
Pharmaceutical research 1992;9(1):70-5.
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