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Nicoletta Pedemonte

Research Profile

Chemicals & Drugs

Disorders

Cystic Fibrosis

Anatomy

Living Beings

Physiology

Co-author Network

Publications

TOP 3
Paolo Scudieri; Elvira Sondo; Valeria Tomati; Olga Zegarra-Moran; Silvia Bruno; Emanuela Caci; Loretta Ferrera; Ambra Gianotti; Nicoletta Pedemonte; Roberto Ravazzolo; Federico Rea; Marco Schiavon; Luis J V Galietta
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.
Michele Giampieri; Maria Anzaldi; Luis J V Galietta; Marco T Mazzei; Erika Nieddu; Nicoletta Pedemonte; Christian Roussel; Nicolas Vanthuyne; Mauro Mazzei
Asymmetric 4-aryl-1,4-dihydropyridines potentiate mutant cystic fibrosis transmembrane conductance regulator (CFTR).
Sonja Visentin; Giuseppe Ermondi; Luis Galietta; Claudio Medana; Nicoletta Pedemonte; Giulia Caron
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators.

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All Publications

2012: Paolo Scudieri; Elvira Sondo; Valeria Tomati; Olga Zegarra-Moran; Silvia Bruno; Emanuela Caci; Loretta Ferrera; Ambra Gianotti; Nicoletta Pedemonte; Roberto Ravazzolo; Federico Rea; Marco Schiavon; Luis J V Galietta
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia.
The Journal of physiology 2012;590(Pt 23):6141-55.
2012: Michele Giampieri; Maria Anzaldi; Luis J V Galietta; Marco T Mazzei; Erika Nieddu; Nicoletta Pedemonte; Christian Roussel; Nicolas Vanthuyne; Mauro Mazzei
Asymmetric 4-aryl-1,4-dihydropyridines potentiate mutant cystic fibrosis transmembrane conductance regulator (CFTR).
ChemMedChem 2012;7(10):1799-807.
2012: Sonja Visentin; Giuseppe Ermondi; Luis Galietta; Claudio Medana; Nicoletta Pedemonte; Giulia Caron
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators.
European journal of medicinal chemistry 2012;55():188-94.
2012: Nicoletta Pedemonte; Luis J V Galietta
Pharmacological Correctors of Mutant CFTR Mistrafficking.
Frontiers in pharmacology 2012;3():175.
2011: Elvira Sondo; Valeria Tomati; Emanuela Caci; Alessia Isabella Esposito; Nicoletta Pedemonte; Ulrich Pfeffer; Luis J V Galietta
Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.
American journal of physiology. Cell physiology 2011;301(4):C872-85.
2011: Roberta Budriesi; Pierfranco Ioan; Alberto Leoni; Nicoletta Pedemonte; Alessandra Locatelli; Matteo Micucci; Alberto Chiarini; Luis J V Galietta
Cystic fibrosis: a new target for 4-Imidazo[2,1-b]thiazole-1,4-dihydropyridines.
Journal of medicinal chemistry 2011;54(11):3885-94.
2011: Nicoletta Pedemonte; Valeria Tomati; Elvira Sondo; Emanuela Caci; Enrico Millo; Andrea Armirotti; Gianluca Damonte; Olga Zegarra-Moran; Luis J V Galietta
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.
The Journal of biological chemistry 2011;286(17):15215-26.
2011: Nicoletta Pedemonte; Olga Zegarra-Moran; Luis J V Galietta
High-throughput screening of libraries of compounds to identify CFTR modulators.
Methods in molecular biology (Clifton, N.J.) 2011;741():13-21.
2010: Ori Kalid; Martin Mense; Sharon Fischman; Alina Shitrit; Hermann Bihler; Efrat Ben-Zeev; Nili Schutz; Nicoletta Pedemonte; Philip J Thomas; Robert J Bridges; Diana R Wetmore; Yael Marantz; Hanoch Senderowitz
Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.
Journal of computer-aided molecular design 2010;24(12):971-91.
2010: Nicoletta Pedemonte; Valeria Tomati; Elvira Sondo; Luis J V Galietta
Influence of cell background on pharmacological rescue of mutant CFTR.
American journal of physiology. Cell physiology 2010;298(4):C866-74.
2009: Francesca Cateni; Marina Zacchigna; Nicoletta Pedemonte; Luis J V Galietta; Marco T Mazzei; Paola Fossa; Michele Giampieri; Mauro Mazzei
Synthesis of 4-thiophen-2'-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel.
Bioorganic & medicinal chemistry 2009;17(23):7894-903.
2009: Antonella Caputo; Alexandre Hinzpeter; Emanuela Caci; Nicoletta Pedemonte; Nicole Arous; Marco Di Duca; Olga Zegarra-Moran; Pascale Fanen; Luis J V Galietta
Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators.
The Journal of pharmacology and experimental therapeutics 2009;330(3):783-91.
2009: Emanuela Caci; Raffaella Melani; Nicoletta Pedemonte; Guelnihal Yueksekdag; Roberto Ravazzolo; Joseph Rosenecker; Luis J V Galietta; Olga Zegarra-Moran
Epithelial sodium channel inhibition in primary human bronchial epithelia by transfected siRNA.
American journal of respiratory cell and molecular biology 2009;40(2):211-6.
2008: Antonella Caputo; Emanuela Caci; Loretta Ferrera; Nicoletta Pedemonte; Cristina Barsanti; Elvira Sondo; Ulrich Pfeffer; Roberto Ravazzolo; Olga Zegarra-Moran; Luis J V Galietta
TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity.
Science (New York, N.Y.) 2008;322(5901):590-4.
2007: Nicoletta Pedemonte; Davide Boido; Oscar Moran; Michele Giampieri; Mauro Mazzei; Roberto Ravazzolo; Luis J V Galietta
Structure-activity relationship of 1,4-dihydropyridines as potentiators of the cystic fibrosis transmembrane conductance regulator chloride channel.
Molecular pharmacology 2007;72(1):197-207.
2007: Nicoletta Pedemonte; Emanuela Caci; Elvira Sondo; Antonella Caputo; Kerry Rhoden; Ulrich Pfeffer; Michele Di Candia; Roberto Bandettini; Roberto Ravazzolo; Olga Zegarra-Moran; Luis J V Galietta
Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(8):5144-53.
2007: Tullia Diena; Raffaella Melani; Emanuela Caci; Nicoletta Pedemonte; Elvira Sondo; Olga Zegarra-Moran; Luis J V Galietta
Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.
European journal of pharmacology 2007;560(2-3):127-31.
2007: Naoaki Fujii; Jose J Haresco; Kathleen A P Novak; Robert M Gage; Nicoletta Pedemonte; David Stokoe; Irwin D Kuntz; R Kiplin Guy
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.
Bioorganic & medicinal chemistry letters 2007;17(2):549-52.
2007: Giovanni Candiano; Maurizio Bruschi; Nicoletta Pedemonte; Luca Musante; Roberto Ravazzolo; Sabrina Liberatori; Luca Bini; Luis J V Galietta; Olga Zegarra-Moran
Proteomic analysis of the airway surface liquid: modulation by proinflammatory cytokines.
American journal of physiology. Lung cellular and molecular physiology 2007;292(1):L185-98.
2006: Xiaohui Fang; Yuanlin Song; Jan Hirsch; Luis J V Galietta; Nicoletta Pedemonte; Rachel L Zemans; Gregory M Dolganov; Alan S Verkman; Michael A Matthay
Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells.
American journal of physiology. Lung cellular and molecular physiology 2006;290(2):L242-9.
2005: Nicoletta Pedemonte; Tullia Diena; Emanuela Caci; Erika Nieddu; Mauro Mazzei; Roberto Ravazzolo; Olga Zegarra-Moran; Luis J V Galietta
Antihypertensive 1,4-dihydropyridines as correctors of the cystic fibrosis transmembrane conductance regulator channel gating defect caused by cystic fibrosis mutations.
Molecular pharmacology 2005;68(6):1736-46.
2005: Giovanni Candiano; Maurizio Bruschi; Nicoletta Pedemonte; Emanuela Caci; Sabrina Liberatori; Luca Bini; Carlo Pellegrini; Mario Viganò; Brian J O'Connor; Tak H Lee; Luis J V Galietta; Olga Zegarra-Moran
Gelsolin secretion in interleukin-4-treated bronchial epithelia and in asthmatic airways.
American journal of respiratory and critical care medicine 2005;172(9):1090-6.
2005: Nicoletta Pedemonte; Gergely L Lukacs; Kai Du; Emanuela Caci; Olga Zegarra-Moran; Luis J V Galietta; Alan S Verkman
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.
The Journal of clinical investigation 2005;115(9):2564-71.
2005: Meena Murthy; Nicoletta Pedemonte; Lesley MacVinish; Luis J V Galietta; Alan W Cuthbert
4-Chlorobenzo[F]isoquinoline (CBIQ), a novel activator of CFTR and DeltaF508 CFTR.
European journal of pharmacology 2005;516(2):118-24.
2005: Nicoletta Pedemonte; Nitin D Sonawane; Alessandro Taddei; Jie Hu; Olga Zegarra-Moran; Yat Fan Suen; Lori I Robins; Christopher W Dicus; Dan Willenbring; Michael H Nantz; Mark J Kurth; Luis J V Galietta; Alan S Verkman
Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating.
Molecular pharmacology 2005;67(5):1797-807.
2004: Danieli Salinas; Nicoletta Pedemonte; Chatchai Muanprasat; Walter F Finkbeiner; Dennis W Nielson; Alan S Verkman
CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor.
American journal of physiology. Lung cellular and molecular physiology 2004;287(5):L936-43.
2004: Yuanlin Song; Nitin D Sonawane; Danieli Salinas; Liman Qian; Nicoletta Pedemonte; Luis J V Galietta; Alan S Verkman
Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models.
The Journal of biological chemistry 2004;279(39):40629-33.
2004: Luis J V Galietta; Chiara Folli; Emanuela Caci; Nicoletta Pedemonte; Alessandro Taddei; Roberto Ravazzolo; Olga Zegarra-Moran
Effect of inflammatory stimuli on airway ion transport.
Proceedings of the American Thoracic Society 2004;1(1):62-5.
2003: Hong Yang; Anang A Shelat; R Kiplin Guy; Vadiraj S Gopinath; Tonghui Ma; Kai Du; Gergely L Lukacs; Alessandro Taddei; Chiara Folli; Nicoletta Pedemonte; Luis J V Galietta; Alan S Verkman
Nanomolar affinity small molecule correctors of defective Delta F508-CFTR chloride channel gating.
The Journal of biological chemistry 2003;278(37):35079-85.
2002: Stefania Deplano; Nicoletta Pedemonte
Spatial organization of displaced ganglion cells in the chick retina.
Visual neuroscience 2002;19(6):727-34.
2002: Tonghui Ma; L Vetrivel; Hong Yang; Nicoletta Pedemonte; Olga Zegarra-Moran; Luis J V Galietta; Alan S Verkman
High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening.
The Journal of biological chemistry 2002;277(40):37235-41.