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Iris Lindberg

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Michael Helwig; Akina Hoshino; Sang-Nam Lee; Casey Berridge; Jason L Eriksen; Nikolai Lorenzen; Daniel E Otzen; Iris Lindberg
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.
Austin B Yongye; Mirella Vivoli; Jon R Appel; Richard A Houghten; Iris Lindberg; Karina Martinez-Mayorga
Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study.
Lindsay A Pickett; R Sergio Solorzano-Vargas; Michael Yourshaw; Valeria Albornoz; Zijun Chen; Martín G Martín; Stanley F Nelson; Iris Lindberg
Functional consequences of a novel variant of PCSK1.

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All Publications

2013: Michael Helwig; Akina Hoshino; Sang-Nam Lee; Casey Berridge; Jason L Eriksen; Nikolai Lorenzen; Daniel E Otzen; Iris Lindberg
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins.
The Journal of biological chemistry 2013;288(2):1114-24.
2013: Austin B Yongye; Mirella Vivoli; Jon R Appel; Richard A Houghten; Iris Lindberg; Karina Martinez-Mayorga
Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study.
PloS one 2013;8(2):e56957.
2013: Lindsay A Pickett; R Sergio Solorzano-Vargas; Michael Yourshaw; Valeria Albornoz; Zijun Chen; Martín G Martín; Stanley F Nelson; Iris Lindberg
Functional consequences of a novel variant of PCSK1.
PloS one 2013;8(1):e55065.
2013: Baozhi Yuan; Robert D Blank; Stephen Bowman; Jian Q Feng; Iris Lindberg; Ying Liu; Marc K Drezner
Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(1):56-72.
2012: Jingjing Zhu; Guido David; Jeroen Declercq; Gholamreza H Ghassabeh; Jörg Kinne; Iris Lindberg; Sandra M P Meulemans; Serge Muyldermans; Bart Roucourt; Wim J M Van De Ven; Alphons J M Vermorken; John W M Creemers
Generation and characterization of non-competitive furin-inhibiting nanobodies.
The Biochemical journal 2012;448(1):73-82.
2012: Indrani Dasgupta; Jan J Enghild; Laura Sanglas; Iris Lindberg
The neuroendocrine protein 7B2 is intrinsically disordered.
Biochemistry 2012;51(38):7456-64.
2012: Gero L Becker; Robert Day; Wolfgang Garten; Kornelia Hardes; Christine Levesque; Iris Lindberg; Yinghui Lu; Kirsten Sandvig; Udo Bakowsky; Boris Strehlow; Torsten Steinmetzer
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
The Journal of biological chemistry 2012;287(26):21992-2003.
2012: Mirella Vivoli; Karina Martínez-Mayorga; Thomas R Caulfield; Guan-Sheng Jiao; Alan T Johnson; Iris Lindberg
Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives.
Molecular pharmacology 2012;81(3):440-54.
2012: Lawrence Toll; Shainnel O Eans; Taline V Khroyan; Iris Lindberg; Jay P McLaughlin; Akihiko Ozawa; Amir A Shahien; Kemal Sonmez; Daniel R Kapusta
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(2):947-54.
2011: Michael Helwig; Jae Ryoung Hwang; Sang-Nam Lee; Juan F Medrano; Akihiko Ozawa; Iris Lindberg
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
The Journal of biological chemistry 2011;286(49):42504-13.
2011: Miriam Kuester; Iris Lindberg; Torsten Steinmetzer; Gero L Becker; Kornelia Hardes; Manuel E Than
Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors.
Biological chemistry 2011;392(11):973-81.
2011: Michael Helwig; Lloyd D Fricker; Mirella Vivoli; Iris Lindberg
Regulation of neuropeptide processing enzymes by catecholamines in endocrine cells.
Molecular pharmacology 2011;80(2):304-13.
2011: Akihiko Ozawa; Adam N Lick; Iris Lindberg
Processing of proaugurin is required to suppress proliferation of tumor cell lines.
Molecular endocrinology (Baltimore, Md.) 2011;25(5):776-84.
2011: Akina Hoshino; Dorota Kowalska; François Jean; Claude Lazure; Iris Lindberg
Modulation of PC1/3 activity by self-interaction and substrate binding.
Endocrinology 2011;152(4):1402-11.
2011: Frank Sielaff; Manuel E Than; Dorian Bevec; Iris Lindberg; Torsten Steinmetzer
New furin inhibitors based on weakly basic amidinohydrazones.
Bioorganic & medicinal chemistry letters 2011;21(2):836-40.
2011: Iris Lindberg; Jon R Appel
Inhibitor screening of proprotein convertases using positional scanning libraries.
Methods in molecular biology (Clifton, N.J.) 2011;768():155-66.
2010: Mario A Izidoro; Diego M Assis; Vitor Oliveira; Jorge A N Santos; Maria A Juliano; Iris Lindberg; Luiz Juliano
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.
Biological chemistry 2010;391(9):1105-12.
2010: Akihiko Ozawa; Juan R Peinado; Iris Lindberg
Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis.
Endocrinology 2010;151(9):4437-45.
2010: Akihiko Ozawa; Iris Lindberg; Bryan Roth; Wesley K Kroeze
Deorphanization of novel peptides and their receptors.
The AAPS journal 2010;12(3):378-84.
2010: Gero L Becker; Frank Sielaff; Manuel E Than; Iris Lindberg; Sophie Routhier; Robert Day; Yinghui Lu; Wolfgang Garten; Torsten Steinmetzer
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Journal of medicinal chemistry 2010;53(3):1067-75.
2009: Mario A Izidoro; Iuri E Gouvea; Jorge A N Santos; Diego M Assis; Vitor Oliveira; Wagner A S Judice; Maria A Juliano; Iris Lindberg; Luiz Juliano
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions.
Archives of biochemistry and biophysics 2009;487(2):105-14.
2009: Dorota Kowalska; Jin Liu; Jon R Appel; Akihiko Ozawa; Adel Nefzi; Robert B Mackin; Richard A Houghten; Iris Lindberg
Synthetic small-molecule prohormone convertase 2 inhibitors.
Molecular pharmacology 2009;75(3):617-25.
2009: H Kudo; J Liu; E J R Jansen; Akihiko Ozawa; Pertti Panula; G J M Martens; Iris Lindberg
Identification of proSAAS homologs in lower vertebrates: conservation of hydrophobic helices and convertase-inhibiting sequences.
Endocrinology 2009;150(3):1393-9.
2009: Akihiko Ozawa; Richard B Speaker; Iris Lindberg
Enzymatic characterization of a human acyltransferase activity.
PloS one 2009;4(5):e5426.
2008: Sang-Nam Lee; Iris Lindberg
7B2 prevents unfolding and aggregation of prohormone convertase 2.
Endocrinology 2008;149(8):4116-27.
2008: Charles Farber; James Chitwood; Sang-Nam Lee; Ricardo Verdugo; Alma Islas-Trejo; Gonzalo Rincon; Iris Lindberg; Juan F Medrano
Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice.
BMC genetics 2008;9():34.
2007: Andreas Waha; Arend Koch; Wolfgang Hartmann; U Milde; Jörg Felsberg; A Hübner; Thomas Mikeska; Cynthia G Goodyer; Niels Sörensen; Iris Lindberg; Otmar D Wiestler; Torsten Pietsch; A Waha
SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas.
Oncogene 2007;26(38):5662-8.
2007: Akihiko Ozawa; Yang Cai; Iris Lindberg
Production of bioactive peptides in an in vitro system.
Analytical biochemistry 2007;366(2):182-9.
2007: Sang-Nam Lee; Magdalena Kacprzak; Robert Day; Iris Lindberg
Processing and trafficking of a prohormone convertase 2 active site mutant.
Biochemical and biophysical research communications 2007;355(3):825-9.
2007: Sang-Nam Lee; Bonnie Peng; Roxane Desjardins; John E Pintar; Robert Day; Iris Lindberg
Strain-specific steroidal control of pituitary function.
The Journal of endocrinology 2007;192(3):515-25.
2007: Martin Fugere; Jon Appel; Richard A Houghten; Iris Lindberg; Robert Day
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences.
Molecular pharmacology 2007;71(1):323-32.
2006: Sang-Nam Lee; Jae-Ryoung Hwang; Iris Lindberg
Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway.
The Journal of biological chemistry 2006;281(6):3312-20.
2006: Sergey A Shiryaev; Boris I Ratnikov; Alexei V Chekanov; Sergey Sikora; Dmitri V Rozanov; Adam Godzik; Jun Wang; Jeffrey W Smith; Ziwei Huang; Iris Lindberg; Melanie A Samuel; Michael S Diamond; Alex Y Strongin
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase.
The Biochemical journal 2006;393(Pt 2):503-11.
2005: Iris Lindberg
Balancing risk and recovery.
Science (New York, N.Y.) 2005;310(5750):971.
2005: Magdalena Kacprzak; Manuel E Than; Luiz Juliano; Maria A Juliano; Wolfram Bode; Iris Lindberg
Mutations of the PC2 substrate binding pocket alter enzyme specificity.
The Journal of biological chemistry 2005;280(36):31850-8.
2005: Juan Peinado; Virginie Laurent; Sang-Nam Lee; Bonnie W Peng; John E Pintar; Donald F Steiner; Iris Lindberg
Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes.
Endocrinology 2005;146(8):3438-44.
2005: Stefan Henrich; Iris Lindberg; Wolfram Bode; Manuel E Than
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity.
Journal of molecular biology 2005;345(2):211-27.
2004: Juan Peinado; Magdalena Kacprzak; Stephen H Leppla; Iris Lindberg
Cross-inhibition between furin and lethal factor inhibitors.
Biochemical and biophysical research communications 2004;321(3):601-5.
2004: Magdalena Kacprzak; Juan Peinado; Manuel E Than; Jon Appel; Stefan Henrich; Gregory M Lipkind; Richard A Houghten; Wolfram Bode; Iris Lindberg
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.
The Journal of biological chemistry 2004;279(35):36788-94.
2004: Sang-Nam Lee; Emmanuel Prodhomme; Iris Lindberg
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS.
The Journal of endocrinology 2004;182(2):353-64.
2004: Virginie Laurent; Lisa Jaubert-Miazza; Roxane Desjardins; Robert Day; Iris Lindberg
Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice.
Endocrinology 2004;145(2):519-28.
2004: Miroslav S Sarac; Juan Peinado; Stephen H Leppla; Iris Lindberg
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
Infection and immunity 2004;72(1):602-5.
2003: Juan Peinado; Hong Li; Karla Johanning; Iris Lindberg
Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study.
Journal of neurochemistry 2003;87(4):868-78.
2003: Stefan Henrich; Angus Cameron; Gleb P Bourenkov; Reiner Kiefersauer; Robert Huber; Iris Lindberg; Wolfram Bode; Manuel E Than
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
Nature structural biology 2003;10(7):520-6.
2003: Gail A Cornwall; Angus Cameron; Iris Lindberg; Daniel M Hardy; Nathaly Cormier; Nelson Hsia
The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2.
Endocrinology 2003;144(3):901-8.
2003: Qiao-Ling Li; Syed Naqvi; Xiaoxiong Shen; Yanjun Liu; Iris Lindberg; Theodore C Friedman
Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues.
Regulatory peptides 2003;110(3):197-205.
2003: R Winsky-Sommerer; Dominique Grouselle; Catherine Rougeot; V Laurent; J-P David; André Delacourte; Pascal Dournaud; N G Seidah; Iris Lindberg; S Trottier; Jacques Epelbaum
The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease.
Neuroscience 2003;122(2):437-47.
2002: Jens F Rehfeld; Iris Lindberg; Lennart Friis-Hansen
Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals.
Journal of neurochemistry 2002;83(6):1329-37.
2002: Miroslav S Sarac; Angus Cameron; Iris Lindberg
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.
Infection and immunity 2002;70(12):7136-9.
2002: Andrea Laslop; Alexandra Becker; Iris Lindberg; Reiner Fischer-Colbrie
Proteolytic processing of chromogranins is modified in brains of transgenic mice.
Annals of the New York Academy of Sciences 2002;971():49-52.
2002: Virginie Laurent; Iris Lindberg
Mini-RIA: adaptation of conventional 125I-labeled radioimmunoassay to a 96-tube format.
Analytical biochemistry 2002;309(1):143-9.
2002: Xiaorong Zhu; An Zhou; Arunangsu Dey; Christina Norrbom; Raymond Carroll; Chunling Zhang; Virginie Laurent; Iris Lindberg; Randi Ugleholdt; Jens J Holst; Donald F Steiner
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10293-8.
2002: Miroslav S Sarac; Arthur W Zieske; Iris Lindberg
The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities.
Endocrinology 2002;143(6):2324-32.
2002: Miroslav S Sarac; Simon Windeatt; Maria G Castro; Iris Lindberg
Intrapituitary adenoviral administration of 7B2 can extend life span and reverse endocrinological deficiencies in 7B2 null mice.
Endocrinology 2002;143(6):2314-23.
2002: Virginie Laurent; A Kimble; B Peng; P Zhu; John E Pintar; Donald F Steiner; Iris Lindberg
Mortality in 7B2 null mice can be rescued by adrenalectomy: involvement of dopamine in ACTH hypersecretion.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3087-92.
2002: YOLANDA FORTENBERRY; Jae-Ryoung Hwang; Ekaterina V Apletalina; Iris Lindberg
Functional characterization of ProSAAS: similarities and differences with 7B2.
The Journal of biological chemistry 2002;277(7):5175-86.
2002: Jens F Rehfeld; Iris Lindberg; Lennart Friis-Hansen
Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2.
FEBS letters 2002;510(1-2):89-93.
2001: Jae-Ryoung Hwang; Iris Lindberg
Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site.
Journal of neurochemistry 2001;79(2):437-44.
2001: Cherian Zachariah; Angus Cameron; Iris Lindberg; Kuo-Jang Kao; M C Beinfeld; Arthur S Edison
Structural studies of a neuropeptide precursor protein with an RGD proteolytic site.
Biochemistry 2001;40(30):8790-9.
2001: Maria S Quinton; YOLANDA FORTENBERRY; Angus Cameron; Iris Lindberg
Tissue distribution and processing of proSAAS by proprotein convertases.
Journal of neurochemistry 2001;76(6):1833-41.
2000: L Muller; Angus Cameron; YOLANDA FORTENBERRY; Ekaterina V Apletalina; Iris Lindberg
Processing and sorting of the prohormone convertase 2 propeptide.
The Journal of biological chemistry 2000;275(50):39213-22.
2000: Angus Cameron; Jon Appel; Richard A Houghten; Iris Lindberg
Polyarginines are potent furin inhibitors.
The Journal of biological chemistry 2000;275(47):36741-9.
2000: Jae-Ryoung Hwang; D E Siekhaus; Robert S Fuller; Paul H Taghert; Iris Lindberg
Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion.
The Journal of biological chemistry 2000;275(23):17886-93.
2000: Angus Cameron; YOLANDA FORTENBERRY; Iris Lindberg
The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1.
FEBS letters 2000;473(2):135-8.
2000: Ekaterina V Apletalina; L Muller; Iris Lindberg
Mutations in the catalytic domain of prohormone convertase 2 result in decreased binding to 7B2 and loss of inhibition with 7B2 C-terminal peptide.
The Journal of biological chemistry 2000;275(19):14667-77.
2000: Ekaterina V Apletalina; Maria A Juliano; Luiz Juliano; Iris Lindberg
Structure-function analysis of the 7B2 CT peptide.
Biochemical and biophysical research communications 2000;267(3):940-2.
1999: YOLANDA FORTENBERRY; Jing Liu; Iris Lindberg
The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines.
Journal of neurochemistry 1999;73(3):994-1003.
1999: L Muller; P Zhu; Maria A Juliano; Luiz Juliano; Iris Lindberg
A 36-residue peptide contains all of the information required for 7B2-mediated activation of prohormone convertase 2.
The Journal of biological chemistry 1999;274(30):21471-7.
1999: CH Westphal; L Muller; A Zhou; Xiaoling Zhu; Susan Bonner-Weir; M Schambelan; D F Steiner; Iris Lindberg; Philip Leder
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease.
Cell 1999;96(5):689-700.
1999: NS Lamango; Ekaterina V Apletalina; Jing Liu; Iris Lindberg
The proteolytic maturation of prohormone convertase 2 (PC2) is a pH-driven process.
Archives of biochemistry and biophysics 1999;362(2):275-82.
1999: L Muller; Iris Lindberg
The cell biology of the prohormone convertases PC1 and PC2.
Progress in nucleic acid research and molecular biology 1999;63():69-108.
1998: Ekaterina V Apletalina; Jon Appel; NS Lamango; Richard A Houghten; Iris Lindberg
Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library.
The Journal of biological chemistry 1998;273(41):26589-95.
1998: K Johanning; Maria A Juliano; Luiz Juliano; Claude Lazure; NS Lamango; Donald F Steiner; Iris Lindberg
Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates.
The Journal of biological chemistry 1998;273(35):22672-80.
1998: Iris Lindberg; B Tu; L Muller; Ian M Dickerson
Cloning and functional analysis of C. elegans 7B2.
DNA and cell biology 1998;17(8):727-34.
1998: Xiaoling Zhu; L Muller; Richard E Mains; Iris Lindberg
Structural elements of PC2 required for interaction with its helper protein 7B2.
The Journal of biological chemistry 1998;273(2):1158-64.
1998: Robert Day; Claude Lazure; Ajoy Basak; A Boudreault; P Limperis; Weijia Dong; Iris Lindberg
Prodynorphin processing by proprotein convertase 2. Cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity.
The Journal of biological chemistry 1998;273(2):829-36.
1997: L Muller; Xiaoling Zhu; Iris Lindberg
Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding.
The Journal of cell biology 1997;139(3):625-38.
1996: K Johanning; J P Mathis; Iris Lindberg
Processing site blockade results in more efficient conversion of proenkephalin to active opioid peptides.
The Journal of biological chemistry 1996;271(44):27871-8.
1996: Xiaoling Zhu; N S Lamango; Iris Lindberg
Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2.
The Journal of biological chemistry 1996;271(38):23582-7.
1996: N S Lamango; Xiaoling Zhu; Iris Lindberg
Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2.
Archives of biochemistry and biophysics 1996;330(2):238-50.
1996: Xiaoling Zhu; Y Rouille; N S Lamango; Donald F Steiner; Iris Lindberg
Internal cleavage of the inhibitory 7B2 carboxyl-terminal peptide by PC2: a potential mechanism for its inactivation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4919-24.
1996: K Johanning; J P Mathis; Iris Lindberg
Role of PC2 in proenkephalin processing: antisense and overexpression studies.
Journal of neurochemistry 1996;66(3):898-907.
1995: Y Zhou; C Rovere; Patrick Kitabgi; Iris Lindberg
Mutational analysis of PC1 (SPC3) in PC12 cells. 66-kDa PC1 is fully functional.
The Journal of biological chemistry 1995;270(42):24702-6.
1995: AM van Horssen; W H van den Hurk; E M Bailyes; J C Hutton; Gerard J M Martens; Iris Lindberg
Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2.
The Journal of biological chemistry 1995;270(24):14292-6.
1995: Xiaoling Zhu; Iris Lindberg
7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity.
The Journal of cell biology 1995;129(6):1641-50.
1995: M E Rothenberg; C D Eilertson; K Klein; Y Zhou; Iris Lindberg; J K McDonald; R B Mackin; B D Noe
Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.
The Journal of biological chemistry 1995;270(17):10136-46.
1995: Iris Lindberg; W H van den Hurk; C Bui; C J Batie
Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment.
Biochemistry 1995;34(16):5486-93.
1994: Iris Lindberg; S C Ahn; M B Breslin
Cellular distributions of the prohormone processing enzymes PC1 and PC2.
Molecular and cellular neurosciences 1994;5(6):614-22.
1994: Y Zhou; Iris Lindberg
Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion.
The Journal of biological chemistry 1994;269(28):18408-13.
1994: B F O'Hara; David M Donovan; Iris Lindberg; M T Brannock; D D Ricker; C A Moffatt; B A Klaunberg; C Schindler; T S Chang; R J Nelson
Proenkephalin transgenic mice: a short promoter confers high testis expression and reduced fertility.
Molecular reproduction and development 1994;38(3):275-84.
1994: Gerard J M Martens; J A Braks; D W Eib; Y Zhou; Iris Lindberg
The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(13):5784-7.
1994: Iris Lindberg
Evidence for cleavage of the PC1/PC3 pro-segment in the endoplasmic reticulum.
Molecular and cellular neurosciences 1994;5(3):263-8.
1994: A Dupuy; Iris Lindberg; Y Zhou; Huda Akil; Claude Lazure; Michel Chrétien; Nabil G Seidah; R Day
Processing of prodynorphin by the prohormone convertase PC1 results in high molecular weight intermediate forms. Cleavage at a single arginine residue.
FEBS letters 1994;337(1):60-5.
1993: M B Breslin; Iris Lindberg; S Benjannet; J P Mathis; C Lazure; N G Seidah
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
The Journal of biological chemistry 1993;268(36):27084-93.
1993: F S Shen; N G Seidah; Iris Lindberg
Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells.
The Journal of biological chemistry 1993;268(33):24910-5.
1993: Pamela Janet Hornby; S D Rosenthal; J P Mathis; O Vindrola; Iris Lindberg
Immunocytochemical localization of the neuropeptide-synthesizing enzyme PC1 in AtT-20 cells.
Neuroendocrinology 1993;58(5):555-63.
1993: O Vindrola; Iris Lindberg
Release of the prohormone convertase PC1 from AtT-20 cells.
Neuropeptides 1993;25(2):151-60.
1993: Y Zhou; Iris Lindberg
Purification and characterization of the prohormone convertase PC1(PC3).
The Journal of biological chemistry 1993;268(8):5615-23.
1992: J P Mathis; Iris Lindberg
Posttranslational processing of proenkephalin in AtT-20 cells: evidence for cleavage at a Lys-Lys site.
Endocrinology 1992;131(5):2287-96.
1992: O Vindrola; Iris Lindberg
Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells.
Molecular endocrinology (Baltimore, Md.) 1992;6(7):1088-94.
1992: Iris Lindberg; B Lincoln; Christopher J Rhodes
Fluorometric assay of a calcium-dependent, paired-basic processing endopeptidase present in insulinoma granules.
Biochemical and biophysical research communications 1992;183(1):1-7.
1992: S F Roberts; J W Irvine; Iris Lindberg
Characterization of proenkephalin-cleaving proteinases in bovine adrenal chromaffin granules using [35S]proenkephalin copolymerized into sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Journal of neurochemistry 1992;58(2):593-9.
1992: Iris Lindberg; E Shaw
Posttranslational processing of proenkephalin in SK-N-MC cells: evidence for phosphorylation.
Journal of neurochemistry 1992;58(2):448-53.
1991: Iris Lindberg
The new eukaryotic precursor processing proteinases.
Molecular endocrinology (Baltimore, Md.) 1991;5(10):1361-5.
1991: J W Irvine; Iris Lindberg
Partial purification and characterization of a putative prohormone-processing enzyme complex from bovine pituitary.
Endocrinology 1991;128(5):2345-52.
1991: Iris Lindberg; E Shaw; J Finley; D Leone; P Deininger
Posttranslational modifications of rat proenkephalin overexpressed in Chinese hamster ovary cells.
Endocrinology 1991;128(4):1849-56.
1990: J W Irvine; S F Roberts; Iris Lindberg
Electrophoretic analysis of proteinases in sodium dodecyl sulfate-polyacrylamide gels containing copolymerized radiolabeled protein substrates: application to proenkephalin processing enzymes.
Analytical biochemistry 1990;190(1):141-6.
1990: Iris Lindberg; Gary Thomas
Cleavage of proenkephalin by a chromaffin granule processing enzyme.
Endocrinology 1990;126(1):480-7.
1989: F S Shen; S F Roberts; Iris Lindberg
A putative processing enzyme for proenkephalin in bovine adrenal chromaffin granule membranes. Purification and properties.
The Journal of biological chemistry 1989;264(26):15600-5.
1989: F S Shen; Iris Lindberg
Purification and assay of opioid activity of low molecular weight enkephalin-immunoreactive peptides generated by peptic digestion of rat plasma proteins.
Neuropeptides 1989;13(1):17-22.
1988: F S Shen; Iris Lindberg
Characterization of enkephalin-immunoreactive peptides generated by peptic digestion of rat plasma proteins.
Endocrinology 1988;122(6):2905-10.
1988: N B D'Souza; Iris Lindberg
Evidence for the phosphorylation of a proenkephalin-derived peptide, peptide B.
The Journal of biological chemistry 1988;263(5):2548-52.
1987: J C Byrd; J R Naranjo; Iris Lindberg
Proenkephalin gene expression in the PC12 pheochromocytoma cell line: stimulation by sodium butyrate.
Endocrinology 1987;121(4):1299-305.
1987: Pertti Panula; Iris Lindberg
Enkephalins in the rat pituitary gland: immunohistochemical and biochemical observations.
Endocrinology 1987;121(1):48-58.
1986: Iris Lindberg
Reserpine-induced alterations in the processing of proenkephalin in cultured chromaffin cells. Increased amidation.
The Journal of biological chemistry 1986;261(35):16317-22.
1986: Iris Lindberg; L White
Distribution of immunoreactive peptide B in the rat brain.
Biochemical and biophysical research communications 1986;139(3):1024-32.
1986: Iris Lindberg; L White
Reptilian enkephalins: implications for the evolution of proenkephalin.
Archives of biochemistry and biophysics 1986;245(1):1-7.
1986: Y N Wang; Iris Lindberg
Distribution and characterization of the opioid octapeptide met5-enkephalin-arg6-gly7-leu8 in the gastrointestinal tract of the rat.
Cell and tissue research 1986;244(1):77-85.
1985: Iris Lindberg; H Y Yang; E Costa
Release of high molecular weight forms of met5-enkephalin-arg6-gly7-leu8 from rat brain.
Neuropeptides 1985;5(4-6):541-4.
1984: Iris Lindberg; H Y Yang
Distribution of Met5-enkephalin-Arg6-Gly7-Leu8-immunoreactive peptides in rat brain: presence of multiple molecular forms.
Brain research 1984;299(1):73-8.
1984: Iris Lindberg; H Y Yang; E Costa
Further characterization of an enkephalin-generating enzyme from adrenal medullary chromaffin granules.
Journal of neurochemistry 1984;42(5):1411-9.
1983: Iris Lindberg; H Y Yang; E Costa
A high molecular weight form of met5-enkephalin-arg6-gly7-leu8 in rat brain and bovine adrenal chromaffin granules.
Life sciences 1983;33 Suppl 1():5-8.
1982: J L Dahl; Miles L Epstein; B L Silva; Iris Lindberg
Multiple immunoreactive forms of met- and leu-enkephalin in fetal and neonatal rat brain and in rat gut.
Life sciences 1982;31(16-17):1853-6.
1982: Iris Lindberg; H Y Yang; E Costa
Characterization of a partially purified trypsin-like enkephalin-generating enzyme in bovine adrenal medulla.
Life sciences 1982;31(16-17):1713-6.
1982: Iris Lindberg; H Y Yang; E Costa
An enkephalin-generating enzyme in bovine adrenal medulla.
Biochemical and biophysical research communications 1982;106(1):186-93.
1982: Iris Lindberg; H Y Yang; E Costa
Enzymatic production of Met5- and Leu5-enkephalin in adrenal chromaffin granules.
Advances in biochemical psychopharmacology 1982;33():183-91.
1981: Iris Lindberg; J L Dahl
Characterization of enkephalin release from rat striatum.
Journal of neurochemistry 1981;36(2):506-12.
1981: Miles L Epstein; Iris Lindberg; J L Dahl
Development of enkephalinergic neurons in the gut of the chick.
Peptides 1981;2(3):271-6.
1979: Iris Lindberg; S J Smythe; J L Dahl
Regional distribution of enkephalin in bovine brain.
Brain research 1979;168(1):200-4.