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Ole Isacson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Astradsson Arnar; Jenkins Bruce G; Choi Ji-Kyung; Hallett Penelope J; Levesque Michele A; McDowell Jack S; Brownell Anna-Liisa; Spealman Roger D; Isacson Ole
The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.
Cooper Oliver; Astradsson Arnar; Hallett Penny; Robertson Harold; Mendez Ivar; Isacson Ole
Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.
Chung Chee Yeun; Koprich James B; Siddiqi Hasan; Isacson Ole
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

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All Publications

2009: Astradsson Arnar; Jenkins Bruce G; Choi Ji-Kyung; Hallett Penelope J; Levesque Michele A; McDowell Jack S; Brownell Anna-Liisa; Spealman Roger D; Isacson Ole
The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.
Neurobiology of disease 2009;35(3):348-51.
2009: Cooper Oliver; Astradsson Arnar; Hallett Penny; Robertson Harold; Mendez Ivar; Isacson Ole
Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.
Journal of neurology 2009;256 Suppl 3():310-6.
2009: Chung Chee Yeun; Koprich James B; Siddiqi Hasan; Isacson Ole
Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(11):3365-73.
2009: Soldner Frank; Hockemeyer Dirk; Beard Caroline; Gao Qing; Bell George W; Cook Elizabeth G; Hargus Gunnar; Blak Alexandra; Cooper Oliver; Mitalipova Maisam; Isacson Ole; Jaenisch Rudolf
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.
Cell 2009;136(5):964-77.
2009: Zhang Jingping; Xu Tai-Xiang; Hallett Penelope J; Watanabe Masahiko; Grant Seth G N; Isacson Ole; Yao Wei-Dong
PSD-95 uncouples dopamine-glutamate interaction in the D1/PSD-95/NMDA receptor complex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(9):2948-60.
2009: Lin Ling; Lesnick Timothy G; Maraganore Demetrius M; Isacson Ole
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Trends in neurosciences 2009;32(3):142-9.
2009: Pruszak Jan; Isacson Ole
Molecular and cellular determinants for generating ES-cell derived dopamine neurons for cell therapy.
Advances in experimental medicine and biology 2009;651():112-23.
2008: Isacson Ole; Kordower Jeffrey H
Future of cell and gene therapies for Parkinson's disease.
Annals of neurology 2008;64 Suppl 2():S122-38.
2008: Hedlund Eva; Isacson Ole
ALS model glia can mediate toxicity to motor neurons derived from human embryonic stem cells.
Cell stem cell 2008;3(6):575-6.
2008: Vinuela A; Hallett P J; Reske-Nielsen C; Patterson M; Sotnikova T D; Caron M G; Gainetdinov R R; Isacson O
Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
Brain : a journal of neurology 2008;131(Pt 12):3361-79.
2008: Seo Hyemyung; Kim Woori; Isacson Ole
Compensatory changes in the ubiquitin-proteasome system, brain-derived neurotrophic factor and mitochondrial complex II/III in YAC72 and R6/2 transgenic mice partially model Huntington's disease patients.
Human molecular genetics 2008;17(20):3144-53.
2008: de Chevigny Antoine; Cooper Oliver; Vinuela Angel; Reske-Nielsen Casper; Lagace Diane C; Eisch Amelia J; Isacson Ole
Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum.
Stem cells (Dayton, Ohio) 2008;26(9):2349-60.
2008: Sanchez-Pernaute Rosario; Lee Hyojin; Patterson Michaela; Reske-Nielsen Casper; Yoshizaki Takahito; Sonntag Kai C; Studer Lorenz; Isacson Ole
Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease.
Brain : a journal of neurology 2008;131(Pt 8):2127-39.
2008: Sanchez-Pernaute R; Wang J-Q; Kuruppu D; Cao L; Tueckmantel W; Kozikowski A; Isacson O; Brownell A-L
Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates.
NeuroImage 2008;42(1):248-51.
2008: Viaro Riccardo; Sanchez-Pernaute Rosario; Marti Matteo; Trapella Claudio; Isacson Ole; Morari Michele
Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism.
Neurobiology of disease 2008;30(3):430-8.
2008: Hedlund Eva; Pruszak Jan; Lardaro Thomas; Ludwig Wesley; Viñuela Angel; Kim Kwang-Soo; Isacson Ole
Embryonic stem cell-derived Pitx3-enhanced green fluorescent protein midbrain dopamine neurons survive enrichment by fluorescence-activated cell sorting and function in an animal model of Parkinson's disease.
Stem cells (Dayton, Ohio) 2008;26(6):1526-36.
2008: Mendez Ivar; Viñuela Angel; Astradsson Arnar; Mukhida Karim; Hallett Penelope; Robertson Harold; Tierney Travis; Holness Renn; Dagher Alain; Trojanowski John Q; Isacson Ole
Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years.
Nature medicine 2008;14(5):507-9.
2008: Wernig Marius; Zhao Jian-Ping; Pruszak Jan; Hedlund Eva; Fu Dongdong; Soldner Frank; Broccoli Vania; Constantine-Paton Martha; Isacson Ole; Jaenisch Rudolf
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(15):5856-61.
2008: Hong Sunghoi; Kang Un Jung; Isacson Ole; Kim Kwang-Soo
Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons.
Journal of neurochemistry 2008;104(2):316-24.
2008: Redmond D E; Vinuela A; Kordower J H; Isacson O
Influence of cell preparation and target location on the behavioral recovery after striatal transplantation of fetal dopaminergic neurons in a primate model of Parkinson's disease.
Neurobiology of disease 2008;29(1):103-16.
2008: Astradsson Arnar; Cooper Oliver; Vinuela Angel; Isacson Ole
Recent advances in cell-based therapy for Parkinson disease.
Neurosurgical focus 2008;24(3-4):E6.
2008: Koprich James B; Reske-Nielsen Casper; Mithal Prabhakar; Isacson Ole
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease.
Journal of neuroinflammation 2008;5():8.
2007: Hedlund Eva; Hefferan Michael P; Marsala Martin; Isacson Ole
Cell therapy and stem cells in animal models of motor neuron disorders.
The European journal of neuroscience 2007;26(7):1721-37.
2007: Brunlid Gabriella; Pruszak Jan; Holmes Benjamin; Isacson Ole; Sonntag Kai-Christian
Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.
Stem cells (Dayton, Ohio) 2007;25(10):2551-8.
2007: Inoue Haruhisa; Lin Ling; Lee Xinhua; Shao Zhaohui; Mendes Shannon; Snodgrass-Belt Pamela; Sweigard Harry; Engber Tom; Pepinsky Blake; Yang Lichuan; Beal M Flint; Mi Sha; Isacson Ole
Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(36):14430-5.
2007: Hong Sunghoi; Hwang Dong-Youn; Yoon Soonsang; Isacson Ole; Ramezani Ali; Hawley Robert G; Kim Kwang-Soo
Functional analysis of various promoters in lentiviral vectors at different stages of in vitro differentiation of mouse embryonic stem cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(9):1630-9.
2007: Pruszak Jan; Sonntag Kai-Christian; Aung Moe Hein; Sanchez-Pernaute Rosario; Isacson Ole
Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations.
Stem cells (Dayton, Ohio) 2007;25(9):2257-68.
2007: Hemming Matthew L; Patterson Michaela; Reske-Nielsen Casper; Lin Ling; Isacson Ole; Selkoe Dennis J
Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.
PLoS medicine 2007;4(8):e262.
2007: Chung Chee Yeun; Koprich James B; Endo Shogo; Isacson Ole
An endogenous serine/threonine protein phosphatase inhibitor, G-substrate, reduces vulnerability in models of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(31):8314-23.
2007: Sánchez-Pernaute Rosario; Jenkins Bruce G; Choi Ji-Kyung; Iris Chen Yin-Ching; Isacson Ole
In vivo evidence of D3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias.
Neurobiology of disease 2007;27(2):220-7.
2007: Zhang Jingping; Vinuela Angel; Neely Mark H; Hallett Penelope J; Grant Seth G N; Miller Gregory M; Isacson Ole; Caron Marc G; Yao Wei-Dong
Inhibition of the dopamine D1 receptor signaling by PSD-95.
The Journal of biological chemistry 2007;282(21):15778-89.
2007: Hedlund Eva; Pruszak Jan; Ferree Andrew; Viñuela Angel; Hong Sunghoi; Isacson Ole; Kim Kwang-Soo
Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations.
Stem cells (Dayton, Ohio) 2007;25(5):1126-35.
2007: Sonntag Kai-Christian; Pruszak Jan; Yoshizaki Takahito; van Arensbergen Joris; Sanchez-Pernaute Rosario; Isacson Ole
Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin.
Stem cells (Dayton, Ohio) 2007;25(2):411-8.
2007: Isacson Ole
Ole Isacson: development of new therapies for Parkinson's disease (interview).
Journal of visualized experiments : JoVE 2007;(3):189.
2007: Seo Hyemyung; Sonntag Kai-Christian; Kim Woori; Cattaneo Elena; Isacson Ole
Proteasome activator enhances survival of huntington's disease neuronal model cells.
PloS one 2007;2(2):e238.
2006: Karki Shreeya; Pruszak Jan; Isacson Ole; Sonntag Kai C
ES cell-derived neuroepithelial cell cultures.
Journal of visualized experiments : JoVE 2006;(1):118.
2006: Lin Ling; Isacson Ole
Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.
Stem cells (Dayton, Ohio) 2006;24(11):2504-13.
2006: Ferrari Daniela; Sanchez-Pernaute Rosario; Lee Hyojin; Studer Lorenz; Isacson Ole
Transplanted dopamine neurons derived from primate ES cells preferentially innervate DARPP-32 striatal progenitors within the graft.
The European journal of neuroscience 2006;24(7):1885-96.
2006: Baker Kasey L; Daniels Stephen B; Lennington Jessica B; Lardaro Thomas; Czap Alexandra; Notti Ryan Q; Cooper Oliver; Isacson Ole; Frasca Salvatore; Conover Joanne C
Neuroblast protuberances in the subventricular zone of the regenerative MRL/MpJ mouse.
The Journal of comparative neurology 2006;498(6):747-61.
2006: Kelly B B; Hedlund E; Kim C; Ishiguro H; Isacson O; Chikaraishi D M; Kim K-S; Feng G
A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene.
Neuroscience 2006;142(2):343-54.
2006: Isacson Ole
What are the long-term effects of neural grafting in patients with Huntington's disease?
Nature clinical practice. Neurology 2006;2(9):470-1.
2006: Chung S; Shin B-S; Hedlund E; Pruszak J; Ferree A; Kang Un Jung; Isacson Ole; Kim Kwang-Soo
Genetic selection of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation.
Journal of neurochemistry 2006;97(5):1467-80.
2006: Chung Sangmi; Shin Byoung-Soo; Hwang Michelle; Lardaro Thomas; Kang Un Jung; Isacson Ole; Kim Kwang-Soo
Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro.
Stem cells (Dayton, Ohio) 2006;24(6):1583-93.
2006: Krichevsky Anna M; Sonntag Kai-C; Isacson Ole; Kosik Kenneth S
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Stem cells (Dayton, Ohio) 2006;24(4):857-64.
2006: Kim Dong-Wook; Chung Sangmi; Hwang Mikyeong; Ferree Andrew; Tsai Hsing-Chen; Park Jae-Joon; Chung Seungsoo; Nam Taick Sang; Kang Un Jung; Isacson Ole; Kim Kwang-Soo
Stromal cell-derived inducing activity, Nurr1, and signaling molecules synergistically induce dopaminergic neurons from mouse embryonic stem cells.
Stem cells (Dayton, Ohio) 2006;24(3):557-67.
2005: Sánchez-Pernaute Rosario; Brownell Anna-Liisa; Jenkins Bruce G; Isacson Ole
Insights into Parkinson's disease models and neurotoxicity using non-invasive imaging.
Toxicology and applied pharmacology 2005;207(2 Suppl):251-6.
2005: Sánchez-Pernaute Rosario; Studer Lorenz; Ferrari Daniela; Perrier Anselme; Lee Hyojin; Viñuela Angel; Isacson Ole
Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation.
Stem cells (Dayton, Ohio) 2005;23(7):914-22.
2005: Chung Chee Yeun; Seo Hyemyung; Sonntag Kai Christian; Brooks Andrew; Lin Ling; Isacson Ole
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.
Human molecular genetics 2005;14(13):1709-25.
2005: Mendez Ivar; Sanchez-Pernaute Rosario; Cooper Oliver; Viñuela Angel; Ferrari Daniela; Björklund Lars; Dagher Alain; Isacson Ole
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease.
Brain : a journal of neurology 2005;128(Pt 7):1498-510.
2005: Seo Hyemyung; Isacson Ole
Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice.
Experimental neurology 2005;193(2):469-80.
2005: Sonntag Kai-Christian; Simantov Rabi; Isacson Ole
Stem cells may reshape the prospect of Parkinson's disease therapy.
Brain research. Molecular brain research 2005;134(1):34-51.
2005: Lin Ling; Rao Yi; Isacson Ole
Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons.
Molecular and cellular neurosciences 2005;28(3):547-55.
2005: Sonntag Kai-Christian; Simantov Rabi; Björklund Lars; Cooper Oliver; Pruszak Jan; Kowalke Florian; Gilmartin Jocelyn; Ding Jixiang; Hu Ya-Ping; Shen Michael M; Isacson Ole
Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells.
Molecular and cellular neurosciences 2005;28(3):417-29.
2005: Chung S; Hedlund E; Hwang M; Kim D W; Shin B-S; Hwang D-Y; Jung Kang Un; Isacson Ole; Kim Kwang-Soo
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons.
Molecular and cellular neurosciences 2005;28(2):241-52.
2004: Kakinohana Osamu; Cizkova Dasa; Tomori Zoltan; Hedlund Eva; Marsala Silvia; Isacson Ole; Marsala Martin
Region-specific cell grafting into cervical and lumbar spinal cord in rat: a qualitative and quantitative stereological study.
Experimental neurology 2004;190(1):122-32.
2004: Jenkins Bruce G; Sanchez-Pernaute Rosario; Brownell Anna-Liisa; Chen Yin-Ching Iris; Isacson Ole
Mapping dopamine function in primates using pharmacologic magnetic resonance imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(43):9553-60.
2004: Cooper Oliver; Isacson Ole
Intrastriatal transforming growth factor alpha delivery to a model of Parkinson's disease induces proliferation and migration of endogenous adult neural progenitor cells without differentiation into dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(41):8924-31.
2004: Seo Hyemyung; Sonntag Kai-Christian; Isacson Ole
Generalized brain and skin proteasome inhibition in Huntington's disease.
Annals of neurology 2004;56(3):319-28.
2004: Isacson Ole
Problems and solutions for circuits and synapses in Parkinson's disease.
Neuron 2004;43(2):165-8.
2004: Sonntag Kai-Christian; Simantov Rabi; Kim Kwang-Soo; Isacson Ole
Temporally induced Nurr1 can induce a non-neuronal dopaminergic cell type in embryonic stem cell differentiation.
The European journal of neuroscience 2004;19(5):1141-52.
2003: Brownell Anna Liisa; Canales Kelly; Chen Y Iris; Jenkins Bruce G; Owen Christopher; Livni Elijahu; Yu Meixiang; Cicchetti Francesca; Sanchez-Pernaute Rosario; Isacson Ole
Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model.
NeuroImage 2003;20(2):1064-75.
2003: Isacson Ole
The production and use of cells as therapeutic agents in neurodegenerative diseases.
Lancet neurology 2003;2(7):417-24.
2003: Kim Kwang-Soo; Kim Chun-Hyung; Hwang Dong-Youn; Seo Hyemyung; Chung Sangmi; Hong Seok Jong; Lim Jin-Kyu; Anderson Therese; Isacson Ole
Orphan nuclear receptor Nurr1 directly transactivates the promoter activity of the tyrosine hydroxylase gene in a cell-specific manner.
Journal of neurochemistry 2003;85(3):622-34.
2003: Cicchetti F; Fodor W; Deacon T W; van Horne C; Rollins S; Burton W; Costantini L C; Isacson O
Immune parameters relevant to neural xenograft survival in the primate brain.
Xenotransplantation 2003;10(1):41-9.
2003: McNaught Kevin St P; Belizaire Roger; Isacson Ole; Jenner Peter; Olanow C Warren
Altered proteasomal function in sporadic Parkinson's disease.
Experimental neurology 2003;179(1):38-46.
2003: Isacson Ole; Bjorklund Lars M; Schumacher James M
Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.
Annals of neurology 2003;53 Suppl 3():S135-46; discussion S146-8.
2002: Chung Sangmi; Sonntag Kai-C; Andersson Therese; Bjorklund Lars M; Park Jae-Joon; Kim Dong-Wook; Kang Un Jung; Isacson Ole; Kim Kwang-Soo
Genetic engineering of mouse embryonic stem cells by Nurr1 enhances differentiation and maturation into dopaminergic neurons.
The European journal of neuroscience 2002;16(10):1829-38.
2002: Cicchetti F; Costantini L; Belizaire R; Burton W; Isacson O; Fodor W
Combined inhibition of apoptosis and complement improves neural graft survival of embryonic rat and porcine mesencephalon in the rat brain.
Experimental neurology 2002;177(2):376-84.
2002: Sánchez-Pernaute R; Brownell A L; Isacson O
Functional imaging of the dopamine system: in vivo evaluation of dopamine deficiency and restoration.
Neurotoxicology 2002;23(4-5):469-78.
2002: McNaught Kevin St P; Björklund Lars M; Belizaire Roger; Isacson Ole; Jenner Peter; Olanow C Warren
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats.
Neuroreport 2002;13(11):1437-41.
2002: McNaught Kevin St P; Belizaire Roger; Jenner Peter; Olanow C Warren; Isacson Ole
Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's disease.
Neuroscience letters 2002;326(3):155-8.
2002: Isacson Ole
Models of repair mechanisms for future treatment modalities of Parkinson's disease.
Brain research bulletin 2002;57(6):839-46.
2002: Seo Hyemyung; Hong Seok Jong; Guo Su; Kim Hee-Sun; Kim Chun-Hyung; Hwang Dong-Youn; Isacson Ole; Rosenthal Arnon; Kim Kwang-Soo
A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity determination.
Journal of neurochemistry 2002;80(5):905-16.
2002: Cicchetti F; Brownell A L; Williams K; Chen Y I; Livni E; Isacson O
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.
The European journal of neuroscience 2002;15(6):991-8.
2002: Seo Hyemyung; Ferree Andrew W; Isacson Ole
Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice.
The European journal of neuroscience 2002;15(3):498-506.
2002: Isacson Ole; Seo Hyemyung; Lin Ling; Albeck David; Granholm Ann Charlotte
Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.
Trends in neurosciences 2002;25(2):79-84.
2002: Bjorklund Lars M; Sánchez-Pernaute Rosario; Chung Sangmi; Andersson Therese; Chen Iris Yin Ching; McNaught Kevin St P; Brownell Anna-Liisa; Jenkins Bruce G; Wahlestedt Claes; Kim Kwang-Soo; Isacson Ole
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2344-9.
2002: Björklund Lars M; Isacson Ole
Regulation of dopamine cell type and transmitter function in fetal and stem cell transplantation for Parkinson's disease.
Progress in brain research 2002;138():411-20.
2002: Costantini Lauren C; Fraefel Cornel; Breakefield Xandra O; Isacson Ole
Herpes simplex virus/adeno-associated virus hybrid vectors for gene transfer to neurons. Preparation and use.
Methods in molecular medicine 2002;69():461-79.
2002: Chung Sangmi; Andersson Therese; Sonntag Kai-C; Björklund Lars; Isacson Ole; Kim Kwang-Soo
Analysis of different promoter systems for efficient transgene expression in mouse embryonic stem cell lines.
Stem cells (Dayton, Ohio) 2002;20(2):139-45.
2001: Williams-Johnso M; Isacson O
Therapeutic approaches: session XI summary and research needs.
Neurotoxicology 2001;22(6):855-8.
2001: Moore A E; Cicchetti F; Hennen J; Isacson O
Parkinsonian motor deficits are reflected by proportional A9/A10 dopamine neuron degeneration in the rat.
Experimental neurology 2001;172(2):363-76.
2001: Hwang D Y; Carlezon W A; Isacson O; Kim K S
A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons.
Human gene therapy 2001;12(14):1731-40.
2001: McNaught K S; Olanow C W; Halliwell B; Isacson O; Jenner P
Failure of the ubiquitin-proteasome system in Parkinson's disease.
Nature reviews. Neuroscience 2001;2(8):589-94.
2001: Browne S E; Lin L; Mattsson A; Georgievska B; Isacson O
Selective antibody-induced cholinergic cell and synapse loss produce sustained hippocampal and cortical hypometabolism with correlated cognitive deficits.
Experimental neurology 2001;170(1):36-47.
2001: Isacson O; Bjorklund L; Pernaute R S
Parkinson's disease: interpretations of transplantation study are erroneous.
Nature neuroscience 2001;4(6):553.
2001: Costantini L C; Cole D; Chaturvedi P; Isacson O
Immunophilin ligands can prevent progressive dopaminergic degeneration in animal models of Parkinson's disease.
The European journal of neuroscience 2001;13(6):1085-92.
2001: Isacson O; van Horne C; Schumacher J M; Brownell A L
Improved surgical cell therapy in Parkinson's disease. Physiological basis and new transplantation methodology.
Advances in neurology 2001;86():447-54.
2001: Holm K H; Cicchetti F; Bjorklund L; Boonman Z; Tandon P; Costantini L C; Deacon T W; Huang X; Chen D F; Isacson O
Enhanced axonal growth from fetal human bcl-2 transgenic mouse dopamine neurons transplanted to the adult rat striatum.
Neuroscience 2001;104(2):397-405.
2000: Freeman T B; Cicchetti F; Hauser R A; Deacon T W; Li X J; Hersch S M; Nauert G M; Sanberg P R; Kordower J H; Saporta S; Isacson O
Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(25):13877-82.
2000: Haque N S; Isacson O
Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultures.
Cell transplantation 2000;9(5):623-7.
2000: Costantini L C; Isacson O
Immunophilin ligands and GDNF enhance neurite branching or elongation from developing dopamine neurons in culture.
Experimental neurology 2000;164(1):60-70.
2000: Emilien G; Ponchon M; Caldas C; Isacson O; Maloteaux J M
Impact of genomics on drug discovery and clinical medicine.
QJM : monthly journal of the Association of Physicians 2000;93(7):391-423.
2000: Fink J S; Schumacher J M; Ellias S L; Palmer E P; Saint-Hilaire M; Shannon K; Penn R; Starr P; VanHorne C; Kott H S; Dempsey P K; Fischman A J; Raineri R; Manhart C; Dinsmore J; Isacson O
Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary results.
Cell transplantation 2000;9(2):273-8.
2000: Schumacher J M; Ellias S A; Palmer E P; Kott H S; Dinsmore J; Dempsey P K; Fischman A J; Thomas C; Feldman R G; Kassissieh S; Raineri R; Manhart C; Penney D; Fink J S; Isacson O
Transplantation of embryonic porcine mesencephalic tissue in patients with PD.
Neurology 2000;54(5):1042-50.
2000: Costantini L C; Bakowska J C; Breakefield X O; Isacson O
Gene therapy in the CNS.
Gene therapy 2000;7(2):93-109.
2000: Isacson O; Lin L
Cholinergic modulation of amyloid processing and dementia in animal models of Alzheimer's disease.
Annals of the New York Academy of Sciences 2000;920():309-14.
2000: Kordower J H; Isacson O; Leventhal L; Emerich D F
Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?
Progress in brain research 2000;127():414-30.
2000: Costantini L C; Isacson O
Neuroimmunophilin ligand enhances neurite outgrowth and effect of fetal dopamine transplants.
Neuroscience 2000;100(3):515-20.
1999: Costantini L C; Jacoby D R; Wang S; Fraefel C; Breakefield X O; Isacson O
Gene transfer to the nigrostriatal system by hybrid herpes simplex virus/adeno-associated virus amplicon vectors.
Human gene therapy 1999;10(15):2481-94.
1999: Lin L; Georgievska B; Mattsson A; Isacson O
Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12108-13.
1999: Chen Y I; Brownell A L; Galpern W; Isacson O; Bogdanov M; Beal M F; Livni E; Rosen B R; Jenkins B G
Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment.
Neuroreport 1999;10(14):2881-6.
1999: Kordower J H; Isacson O; Emerich D F
Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?
Experimental neurology 1999;159(1):4-20.
1999: Isacson O; Sladek J R
Cellular and molecular treatments of neurological diseases.
Experimental neurology 1999;159(1):1-3.
1999: Isacson O
The neurobiology and neurogenetics of stem cells.
Brain pathology (Zurich, Switzerland) 1999;9(3):495-8.
1999: Holm K; Isacson O
Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for BCL2?
Trends in neurosciences 1999;22(6):269-73.
1999: Brownell A L; Jenkins B G; Isacson O
Dopamine imaging markers and predictive mathematical models for progressive degeneration in Parkinson's disease.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 1999;53(3):131-40.
1999: Boonman Z; Isacson O
Apoptosis in neuronal development and transplantation: role of caspases and trophic factors.
Experimental neurology 1999;156(1):1-15.
1999: LeBlanc C J; Deacon T W; Whatley B R; Dinsmore J; Lin L; Isacson O
Morris water maze analysis of 192-IgG-saporin-lesioned rats and porcine cholinergic transplants to the hippocampus.
Cell transplantation 1999;8(1):131-42.
1999: Deacon T; Whatley B; LeBlanc C; Lin L; Isacson O
Pig fetal septal neurons implanted into the hippocampus of aged or cholinergic deafferented rats grow axons and form cross-species synapses in appropriate target regions.
Cell transplantation 1999;8(1):111-29.
1998: Brownell A L; Jenkins B G; Elmaleh D R; Deacon T W; Spealman R D; Isacson O
Combined PET/MRS brain studies show dynamic and long-term physiological changes in a primate model of Parkinson disease.
Nature medicine 1998;4(11):1308-12.
1998: Costantini L C; Chaturvedi P; Armistead D M; McCaffrey P G; Deacon T W; Isacson O
A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease.
Neurobiology of disease 1998;5(2):97-106.
1998: Brownell A L; Livni E; Galpern W; Isacson O
In vivo PET imaging in rat of dopamine terminals reveals functional neural transplants.
Annals of neurology 1998;43(3):387-90.
1998: Lin L; LeBlanc C J; Deacon T W; Isacson O
Chronic cognitive deficits and amyloid precursor protein elevation after selective immunotoxin lesions of the basal forebrain cholinergic system.
Neuroreport 1998;9(3):547-52.
1998: Deacon T; Dinsmore J; Costantini L C; Ratliff J; Isacson O
Blastula-stage stem cells can differentiate into dopaminergic and serotonergic neurons after transplantation.
Experimental neurology 1998;149(1):28-41.
1997: Isacson O; Deacon T
Neural transplantation studies reveal the brain's capacity for continuous reconstruction.
Trends in neurosciences 1997;20(10):477-82.
1997: Chen Y C; Galpern W R; Brownell A L; Matthews R T; Bogdanov M; Isacson O; Keltner J R; Beal M F; Rosen B R; Jenkins B G
Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997;38(3):389-98.
1997: Isacson O; Breakefield X O
Benefits and risks of hosting animal cells in the human brain.
Nature medicine 1997;3(9):964-9.
1997: Costantini L C; Lin L; Isacson O
Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts.
Neuroreport 1997;8(9-10):2253-7.
1997: Haque N S; LeBlanc C J; Isacson O
Differential dissection of the rat E16 ventral mesencephalon and survival and reinnervation of the 6-OHDA-lesioned striatum by a subset of aldehyde dehydrogenase-positive TH neurons.
Cell transplantation 1997;6(3):239-48.
1997: Freed W J; Isacson O
A special issue based on the third annual conference of the American Society for Neural Transplantation, 1996.
Cell transplantation 1997;6(3):201-2.
1997: Schumacher J M; Isacson O
Neuronal xenotransplantation in Parkinson's disease.
Nature medicine 1997;3(5):474-5.
1997: Haque N S; Borghesani P; Isacson O
Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder.
Molecular medicine today 1997;3(4):175-83.
1997: Haque N; Isacson O
Antisense gene therapy for neurodegenerative disease?
Experimental neurology 1997;144(1):139-46.
1997: Deacon T; Schumacher J; Dinsmore J; Thomas C; Palmer P; Kott S; Edge A; Penney D; Kassissieh S; Dempsey P; Isacson O
Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease.
Nature medicine 1997;3(3):350-3.
1996: Isacson O; Deacon T W
Specific axon guidance factors persist in the adult brain as demonstrated by pig neuroblasts transplanted to the rat.
Neuroscience 1996;75(3):827-37.
1996: Galpern W R; Matthews R T; Beal M F; Isacson O
NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.
Neuroreport 1996;7(15-17):2639-42.
1996: Galpern W R; Burns L H; Deacon T W; Dinsmore J; Isacson O
Xenotransplantation of porcine fetal ventral mesencephalon in a rat model of Parkinson's disease: functional recovery and graft morphology.
Experimental neurology 1996;140(1):1-13.
1996: Dinsmore J H; Pakzaban P; Deacon T W; Burns L; Isacson O
Survival of transplanted porcine neural cells treated with F(ab')2 antibody fragments directed against donor MHC class-I in a rodent model.
Transplantation proceedings 1996;28(2):817-8.
1996: Galpern W R; Frim D M; Tatter S B; Altar C A; Beal M F; Isacson O
Cell-mediated delivery of brain-derived neurotrophic factor enhances dopamine levels in an MPP+ rat model of substantia nigra degeneration.
Cell transplantation 1996;5(2):225-32.
1996: Dinsmore J; Ratliff J; Deacon T; Pakzaban P; Jacoby D; Galpern W; Isacson O
Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation.
Cell transplantation 1996;5(2):131-43.
1995: Freeman T B; Sanberg P R; Isacson O
Development of the human striatum: implications for fetal striatal transplantation in the treatment of Huntington's disease.
Cell transplantation 1995;4(6):539-45.
1995: Isacson O; Deacon T W; Pakzaban P; Galpern W R; Dinsmore J; Burns L H
Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres.
Nature medicine 1995;1(11):1189-94.
1995: Garcia A R; Deacon T W; Dinsmore J; Isacson O
Extensive axonal and glial fiber growth from fetal porcine cortical xenografts in the adult rat cortex.
Cell transplantation 1995;4(5):515-27.
1995: Isacson O
Behavioral effects and gene delivery in a rat model of Parkinson's disease.
Science (New York, N.Y.) 1995;269(5225):856-7.
1995: Tatter S B; Galpern W R; Hoogeveen A T; Isacson O
Effects of striatal excitotoxicity on huntingtin-like immunoreactivity.
Neuroreport 1995;6(8):1125-9.
1995: Pakzaban P; Deacon T W; Burns L H; Dinsmore J; Isacson O
A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system.
Neuroscience 1995;65(4):983-96.
1995: Burns L H; Pakzaban P; Deacon T W; Brownell A L; Tatter S B; Jenkins B G; Isacson O
Selective putaminal excitotoxic lesions in non-human primates model the movement disorder of Huntington disease.
Neuroscience 1995;64(4):1007-17.
1994: Deacon T W; Pakzaban P; Isacson O
The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence.
Brain research 1994;668(1-2):211-9.
1994: Deacon T W; Pakzaban P; Burns L H; Dinsmore J; Isacson O
Cytoarchitectonic development, axon-glia relationships, and long distance axon growth of porcine striatal xenografts in rats.
Experimental neurology 1994;130(1):151-67.
1994: Pakzaban P; Isacson O
Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers.
Neuroscience 1994;62(4):989-1001.
1994: Andersen J K; Frim D M; Isacson O; Beal M F; Breakefield X O
Elevation of neuronal MAO-B activity in a transgenic mouse model does not increase sensitivity to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
Brain research 1994;656(1):108-14.
1994: Frim D M; Wüllner U; Beal M F; Isacson O
Implanted NGF-producing fibroblasts induce catalase and modify ATP levels but do not affect glutamate receptor binding or NMDA receptor expression in the rat striatum.
Experimental neurology 1994;128(2):172-80.
1994: Pakzaban P; Geller A I; Isacson O
Effect of exogenous nerve growth factor on neurotoxicity of and neuronal gene delivery by a herpes simplex amplicon vector in the rat brain.
Human gene therapy 1994;5(8):987-95.
1994: Frim D M; Uhler T A; Galpern W R; Beal M F; Breakefield X O; Isacson O
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(11):5104-8.
1994: Isacson O
Clinical and preclinical PET correlates of parkinsonism with 11C-WIN 35,428.
Annals of neurology 1994;35(3):377-8.
1994: Uhler T A; Frim D M; Pakzaban P; Isacson O
The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum.
Neurosurgery 1994;34(1):122-7; discussion 127-8.
1993: Andersen J K; Frim D M; Isacson O; Breakefield X O
Herpesvirus-mediated gene delivery into the rat brain: specificity and efficiency of the neuron-specific enolase promoter.
Cellular and molecular neurobiology 1993;13(5):503-15.
1993: Burns L H; Sato K; Wüllner U; Isacson O
Intra-nigra infusion of AMPA attenuates dopamine-dependent rotation in the rat.
Neuroreport 1993;4(9):1075-8.
1993: Isacson O
On neuronal health.
Trends in neurosciences 1993;16(8):306-8.
1993: Frim D M; Simpson J; Uhler T A; Short M P; Bossi S R; Breakefield X O; Isacson O
Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF.
Journal of neuroscience research 1993;35(4):452-8.
1993: Wüllner U; Brouillet E; Isacson O; Young A B; Penney J B
Glutamate receptor binding sites in MPTP-treated mice.
Experimental neurology 1993;121(2):284-7.
1993: Frim D M; Yee W M; Isacson O
NGF reduces striatal excitotoxic neuronal loss without affecting concurrent neuronal stress.
Neuroreport 1993;4(6):655-8.
1993: Simpson J R; Isacson O
Mitochondrial impairment reduces the threshold for in vivo NMDA-mediated neuronal death in the striatum.
Experimental neurology 1993;121(1):57-64.
1993: Frim D M; Uhler T A; Short M P; Ezzedine Z D; Klagsbrun M; Breakefield X O; Isacson O
Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions.
Neuroreport 1993;4(4):367-70.
1993: Frim D M; Short M P; Rosenberg W S; Simpson J; Breakefield X O; Isacson O
Local protective effects of nerve growth factor-secreting fibroblasts against excitotoxic lesions in the rat striatum.
Journal of neurosurgery 1993;78(2):267-73.
1993: Bossi S R; Simpson J R; Isacson O
Age dependence of striatal neuronal death caused by mitochondrial dysfunction.
Neuroreport 1993;4(1):73-6.
1993: Yee W M; Frim D M; Isacson O
Relationships between stress protein induction and NMDA-mediated neuronal death in the entorhinal cortex.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1993;94(2):193-202.
1993: Pakzaban P; Deacon T W; Burns L H; Isacson O
Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1993;97(1):13-22.
1992: Rosenberg W S; Breakefield X O; DeAntonio C; Isacson O
Authentic and artifactual detection of the E. coli lacZ gene product in the rat brain by histochemical methods.
Brain research. Molecular brain research 1992;16(3-4):311-5.
1992: Hantraye P; Leroy-Willig A; Denys A; Riche D; Isacson O; Maziere M; Syrota A
Magnetic resonance imaging to monitor pathology of caudate-putamen after excitotoxin-induced neuronal loss in the nonhuman primate brain.
Experimental neurology 1992;118(1):18-23.
1992: Isacson O; Sofroniew M V
Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems.
Experimental neurology 1992;117(2):151-75.
1992: Beal M F; Swartz K J; Isacson O
Developmental changes in brain kynurenic acid concentrations.
Brain research. Developmental brain research 1992;68(1):136-9.
1992: Hantraye P; Riche D; Maziere M; Isacson O
Intrastriatal transplantation of cross-species fetal striatal cells reduces abnormal movements in a primate model of Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):4187-91.
1992: Hantraye P; Brownell A L; Elmaleh D; Spealman R D; Wüllner U; Brownell G L; Madras B K; Isacson O
Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism.
Neuroreport 1992;3(3):265-8.
1992: Hantraye P; Loc'H C; Maziere B; Khalili-Varasteh M; Crouzel C; Fournier D; Yorke J C; Stulzaft O; Riche D; Isacson O
6-[18F]fluoro-L-dopa uptake and [76Br]bromolisuride binding in the excitotoxically lesioned caudate-putamen of nonhuman primates studied using positron emission tomography.
Experimental neurology 1992;115(2):218-27.
1992: Isacson O; Peschanski M
Is there capacity for anatomical and functional repair in the adult somatosensory thalamus?
Experimental neurology 1992;115(1):173-6.
1992: Schumacher J M; Hantraye P; Brownell A L; Riche D; Madras B K; Davenport P D; Maziere M; Elmaleh D R; Brownell G L; Isacson O
A primate model of Huntington's disease: functional neural transplantation and CT-guided stereotactic procedures.
Cell transplantation 1992;1(4):313-22.
1991: Levisohn L F; Isacson O
Excitotoxic lesions of the rat entorhinal cortex. Effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task.
Brain research 1991;564(2):230-44.
1991: Schumacher J M; Short M P; Hyman B T; Breakefield X O; Isacson O
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.
Neuroscience 1991;45(3):561-70.
1990: Hantraye P; Riche D; Maziere M; Isacson O
A primate model of Huntington's disease: behavioral and anatomical studies of unilateral excitotoxic lesions of the caudate-putamen in the baboon.
Experimental neurology 1990;108(2):91-104.
1990: O'Brien T S; Svendsen C N; Isacson O; Sofroniew M V
Loss of true blue labelling from the medial septum following transection of the fimbria-fornix: evidence for the death of cholinergic and non-cholinergic neurons.
Brain research 1990;508(2):249-56.
1990: Sofroniew M V; Galletly N P; Isacson O; Svendsen C N
Survival of adult basal forebrain cholinergic neurons after loss of target neurons.
Science (New York, N.Y.) 1990;247(4940):338-42.
1990: Sofroniew M V; Dunnett S B; Isacson O
Remodelling of intrinsic and afferent systems in neocortex with cortical transplants.
Progress in brain research 1990;82():313-20.
1990: Isacson O; Hantraye P; Maziere M; Sofroniew M V; Riche D
Apomorphine-induced dyskinesias after excitotoxic caudate-putamen lesions and the effects of neural transplantation in non-human primates.
Progress in brain research 1990;82():523-33.
1989: Dusart I; Isacson O; Nothias F; Gumpel M; Peschanski M
Presence of Schwann cells in neurodegenerative lesions of the central nervous system.
Neuroscience letters 1989;105(3):246-50.
1989: Dunnett S; Isacson O
Trophic mechanisms are not enough.
Trends in neurosciences 1989;12(7):257.
1989: Sofroniew M V; Isacson O; O'Brien T S
Nerve growth factor receptor immunoreactivity in the rat suprachiasmatic nucleus.
Brain research 1989;476(2):358-62.
1989: Wictorin K; Simerly R B; Isacson O; Swanson L W; Björklund A
Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--III. Efferent projecting graft neurons and their relation to host afferents within the grafts.
Neuroscience 1989;30(2):313-30.
1989: Isacson O; Riche D; Hantraye P; Sofroniew M V; Maziere M
A primate model of Huntington's disease: cross-species implantation of striatal precursor cells to the excitotoxically lesioned baboon caudate-putamen.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1989;75(1):213-20.
1988: Lams B E; Isacson O; Sofroniew M V
Loss of transmitter-associated enzyme staining following axotomy does not indicate death of brainstem cholinergic neurons.
Brain research 1988;475(2):401-6.
1988: Sofroniew M V; Isacson O
Distribution of degeneration of cholinergic neurons in the septum following axotomy in different portions of the fimbria-fornix: a correlation between degree of cell loss and proximity of neuronal somata to the lesion.
Journal of chemical neuroanatomy 1988;1(6):327-37.
1988: Wictorin K; Isacson O; Fischer W; Nothias F; Peschanski M; Björklund A
Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum--I. Subcortical afferents.
Neuroscience 1988;27(2):547-62.
1988: Nothias F; Wictorin K; Isacson O; Björklund A; Peschanski M
Morphological alteration of thalamic afferents in the excitotoxically lesioned striatum.
Brain research 1988;461(2):349-54.
1988: Peschanski M; Isacson O
Fetal homotypic transplant in the excitotoxically neuron-depleted thalamus: light microscopy.
The Journal of comparative neurology 1988;274(3):449-63.
1988: Brundin P; Barbin G; Strecker R E; Isacson O; Prochiantz A; Björklund A
Survival and function of dissociated rat dopamine neurones grafted at different developmental stages or after being cultured in vitro.
Brain research 1988;467(2):233-43.
1988: Dunnett S B; Isacson O; Sirinathsinghji D J; Clarke D J; Björklund A
Striatal grafts in rats with unilateral neostriatal lesions--III. Recovery from dopamine-dependent motor asymmetry and deficits in skilled paw reaching.
Neuroscience 1988;24(3):813-20.
1988: Sirinathsinghji D J; Dunnett S B; Isacson O; Clarke D J; Kendrick K; Björklund A
Striatal grafts in rats with unilateral neostriatal lesions--II. In vivo monitoring of GABA release in globus pallidus and substantia nigra.
Neuroscience 1988;24(3):803-11.
1988: Clarke D J; Dunnett S B; Isacson O; Sirinathsinghji D J; Björklund A
Striatal grafts in rats with unilateral neostriatal lesions--I. Ultrastructural evidence of afferent synaptic inputs from the host nigrostriatal pathway.
Neuroscience 1988;24(3):791-801.
1988: Gage F H; Brundin P; Strecker R; Dunnett S B; Isacson O; Bjorklund A
Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction.
Annals of the New York Academy of Sciences 1988;515():383-94.
1988: Björklund A; Brundin P; Isacson O
Neuronal replacement by intracerebral neural implants in animal models of neurodegenerative disease.
Advances in neurology 1988;47():455-92.
1988: Peschanski M; Rudin M; Isacson O; Delepierre M; Roques B P
Magnetic resonance imaging of intracerebral neural grafts.
Progress in brain research 1988;78():619-24.
1988: Wictorin K; Isacson O; Fischer W; Nothias F; Peschanski M; Björklund A
Studies on host afferent inputs to fetal striatal transplants in the excitotoxically lesioned striatum.
Progress in brain research 1988;78():55-60.
1988: Clarke D J; Dunnett S B; Isacson O; Björklund A
Striatal grafts in the ibotenic acid-lesioned neostriatum: ultrastructural and immunocytochemical studies.
Progress in brain research 1988;78():47-53.
1988: Fischer W; Wictorin K; Isacson O; Björklund A
Trophic effects on cholinergic striatal interneurons by submaxillary gland transplants.
Progress in brain research 1988;78():409-12.
1988: Dunnett S B; Isacson O; Sirinathsinghji D J; Clarke D J; Björklund A
Striatal grafts in the ibotenic acid-lesioned neostriatum: functional studies.
Progress in brain research 1988;78():39-45.
1988: Isacson O; Wictorin K; Fischer W; Sofroniew M V; Björklund A
Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neurochemical studies of trophic interactions.
Progress in brain research 1988;78():13-26.
1987: Isacson O; Dawbarn D; Brundin P; Gage F H; Emson P C; Björklund A
Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography.
Neuroscience 1987;22(2):481-97.
1987: Isacson O; Fischer W; Wictorin K; Dawbarn D; Björklund A
Astroglial response in the excitotoxically lesioned neostriatum and its projection areas in the rat.
Neuroscience 1987;20(3):1043-56.
1987: Isacson O; Pritzel M; Dawbarn D; Brundin P; Kelly P A; Wiklund L; Emson P C; Gage F H; Dunnett S B; Björklund A
Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects.
Annals of the New York Academy of Sciences 1987;495():537-55.
1987: Brundin P; Strecker R E; Lindvall O; Isacson O; Nilsson O G; Barbin G; Prochiantz A; Forni C; Nieoullon A; Widner H
Intracerebral grafting of dopamine neurons. Experimental basis for clinical trials in patients with Parkinson's disease.
Annals of the New York Academy of Sciences 1987;495():473-96.
1986: Sofroniew M V; Isacson O; Björklund A
Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage.
Brain research 1986;378(2):409-15.
1986: Dunnett S B; Whishaw I Q; Jones G H; Isacson O
Effects of dopamine-rich grafts on conditioned rotation in rats with unilateral 6-hydroxydopamine lesions.
Neuroscience letters 1986;68(1):127-33.
1986: Isacson O; Dunnett S B; Björklund A
Graft-induced behavioral recovery in an animal model of Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(8):2728-32.
1986: Brundin P; Isacson O; Gage F H; Prochiantz A; Björklund A
The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting.
Brain research 1986;366(1-2):346-9.
1986: Brundin P; Isacson O; Gage F H; Björklund A
Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells.
Brain research 1986;389(1-2):77-84.
1986: Zetterström T; Brundin P; Gage F H; Sharp T; Isacson O; Dunnett S B; Ungerstedt U; Björklund A
In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis.
Brain research 1986;362(2):344-9.
1986: Sofroniew M V; Pearson R C; Isacson O; Björklund A
Experimental studies on the induction and prevention of retrograde degeneration of basal forebrain cholinergic neurons.
Progress in brain research 1986;70():363-89.
1986: Pritzel M; Isacson O; Brundin P; Wiklund L; Björklund A
Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1986;65(1):112-26.
1985: Isacson O; Brundin P; Gage F H; Björklund A
Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting.
Neuroscience 1985;16(4):799-817.
1985: Brundin P; Barbin G; Isacson O; Mallat M; Chamak B; Prochiantz A; Gage F H; Björklund A
Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro.
Neuroscience letters 1985;61(1-2):79-84.
1985: Gage F H; Brundin P; Isacson O; Björklund A
Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage.
Neuroscience letters 1985;60(2):133-7.
1985: Brundin P; Isacson O; Björklund A
Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival.
Brain research 1985;331(2):251-9.
1985: Emson P C; Dawbarn D; Rossor M N; Rehfeld J F; Brundin P; Isacson O; Björklund A
Cholecystokinin content in the basal ganglia in Huntington's disease. The expression of cholecystokinin immunoreactivity in striatal grafts to ibotenic acid-lesioned rat striatum.
Annals of the New York Academy of Sciences 1985;448():488-94.
1984: Isacson O; Brundin P; Kelly P A; Gage F H; Björklund A
Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum.
Nature 1984;311(5985):458-60.
1983: Gage F H; Dunnett S B; Brundin P; Isacson O; Björklund A
Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application.
Developmental neuroscience 1983;6(3):137-51.

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