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Rob Hoeben

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J de Vrij; Steve J Cramer; I J C Dautzenberg; Danijela Koppers-Lalic; Leif Lindholm; Maria K Magnusson; taco uil; S K van den Hengel; Jort Vellinga; C S Verissimo; Rob Hoeben
A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction.
Arnaud Zaldumbide; Shoshan Knaän-Shanzer; Bart O Roep; Emmanuel J H J Wiertz; Françoise Carlotti; Steve J Cramer; Manuel A F V Gonçalves; Rob Hoeben
Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.
Diana J M van den Wollenberg; Sanne K van den Hengel; Steve J Cramer; Iris J C Dautzenberg; Raoul J de Groot; Rob Hoeben
Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

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All Publications

2012: J de Vrij; Steve J Cramer; I J C Dautzenberg; Danijela Koppers-Lalic; Leif Lindholm; Maria K Magnusson; taco uil; S K van den Hengel; Jort Vellinga; C S Verissimo; Rob Hoeben
A cathepsin-cleavage site between the adenovirus capsid protein IX and a tumor-targeting ligand improves targeted transduction.
Gene therapy 2012;19(9):899-906.
2012: Arnaud Zaldumbide; Shoshan Knaän-Shanzer; Bart O Roep; Emmanuel J H J Wiertz; Françoise Carlotti; Steve J Cramer; Manuel A F V Gonçalves; Rob Hoeben
Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.
PloS one 2012;7(10):e48093.
2012: Diana J M van den Wollenberg; Sanne K van den Hengel; Steve J Cramer; Iris J C Dautzenberg; Raoul J de Groot; Rob Hoeben
Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.
PloS one 2012;7(10):e48064.
2012: Maria K Magnusson; N J Maitland; M Van der Kroeg; K A J Van Schie; W M van Weerden; C M A De Ridder; Rob Hoeben; Robert Kraaij; R M Leadley; Leif Lindholm
A transductionally retargeted adenoviral vector for virotherapy of Her2/neu-expressing prostate cancer.
Human gene therapy 2012;23(1):70-82.
2011: Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Leukemia 2011;25(9):1471-83.
2011: taco uil; Jort Vellinga; Jeroen de Vrij; Sanne K van den Hengel; Martijn J W E Rabelink; Steve J Cramer; Julia J M Eekels; Yavuz Ariyurek; Michiel van Galen; Rob Hoeben
Directed adenovirus evolution using engineered mutator viral polymerases.
Nucleic acids research 2011;39(5):e30.
2011: Jeroen de Vrij; Sanne K van den Hengel; taco uil; Danijela Koppers-Lalic; Iris J C Dautzenberg; Oscar M J A Stassen; Montserrat Bárcena; Masato Yamamoto; Corrina M A de Ridder; Robert Kraaij; Kitty M Kwappenberg; Marco W Schilham; Rob Hoeben
Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors.
Virology 2011;410(1):192-200.
2011: Anabel S de la Garza-Rodea; Marieke C Verweij; Hester Boersma; Ietje van der Velde-van Dijke; Antoine A F de Vries; Rob Hoeben; Dirk W van Bekkum; Emmanuel J H J Wiertz; Shoshan Knaän-Shanzer
Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants.
PloS one 2011;6(1):e14493.
2010: Derrick Louz; Hans E Bergmans; Birgit P Loos; Rob Hoeben
Emergence of viral diseases: mathematical modeling as a tool for infection control, policy and decision making.
Critical reviews in microbiology 2010;36(3):195-211.
2010: Jeroen de Vrij; Ralph A Willemsen; Leif Lindholm; Rob Hoeben; Chris H Bangma; Chris Barber; Jean-Paul Behr; Simon Briggs; Robert Carlisle; Wing-Shing Cheng; Iris J C Dautzenberg; Corrina de Ridder; Helena Dzojic; Patrick Erbacher; Magnus Essand; Kerry Fisher; April Frazier; Lindsay J Georgopoulos; Ian Jennings; Stefan Kochanek; Daniela Koppers-Lalic; Robert Kraaij; Florian Kreppel; Maria Magnusson; Norman Maitland; Patrick Neuberg; Regina Nugent; Manfred Ogris; Jean-Serge Remy; Michelle Scaife; Ellen Schenk-Braat; Erik Schooten; Len Seymour; Michael Slade; Pio Szyjanowicz; Thomas Totterman; Taco G Uil; Karel Ulbrich; Laura van der Weel; Wytske van Weerden; Ernst Wagner; Guy Zuber
Adenovirus-derived vectors for prostate cancer gene therapy.
Human gene therapy 2010;21(7):795-805.
2010: Arnaud Zaldumbide; Susan Weening; Steve J Cramer; Martijn J W E Rabelink; Joost Verhaagen; Rob Hoeben
A potentially immunologically inert derivative of the reverse tetracycline-controlled transactivator.
Biotechnology letters 2010;32(6):749-54.
2009: Diana J M van den Wollenberg; Sanne K Van Den Hengel; Iris J C Dautzenberg; Onno Kranenburg; Rob Hoeben
Modification of mammalian reoviruses for use as oncolytic agents.
Expert opinion on biological therapy 2009;9(12):1509-20.
2009: Xiaoli Wang; Roger A Herr; Martijn Rabelink; Rob Hoeben; Emmanuel J H J Wiertz; Ted H Hansen
Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates.
The Journal of cell biology 2009;187(5):655-68.
2009: taco uil; Jeroen de Vrij; Jort Vellinga; Martijn J W E Rabelink; Steve J Cramer; On Ying A Chan; Margherita Pugnali; Maria Magnusson; Leif Lindholm; Pierre Boulanger; Rob Hoeben
A lentiviral vector-based adenovirus fiber-pseudotyping approach for expedited functional assessment of candidate retargeted fibers.
The journal of gene medicine 2009;11(11):990-1004.
2009: Ulrike Bernhardt; Françoise Carlotti; Rob Hoeben; Hans-Georg Joost; Hadi Al-Hasani
A dual role of the N-terminal FQQI motif in GLUT4 trafficking.
Biological chemistry 2009;390(9):883-92.
2009: H Bea Kuiperij; Melissa van Pel; Karien E de Rooij; Rob Hoeben; Willem E Fibbe
Serpina1 (alpha1-AT) is synthesized in the osteoblastic stem cell niche.
Experimental hematology 2009;37(5):641-7.
2008: Diana J M van den Wollenberg; S K van den Hengel; I J C Dautzenberg; Steve J Cramer; O Kranenburg; Rob Hoeben
A strategy for genetic modification of the spike-encoding segment of human reovirus T3D for reovirus targeting.
Gene therapy 2008;15(24):1567-78.
2008: Alexandra Chadt; Katja Leicht; Atul Deshmukh; Lake Q Jiang; Stephan Scherneck; Ulrike Bernhardt; Tanja Dreja; Heike Vogel; Katja Schmolz; Reinhart Kluge; Juleen R Zierath; Claus Hultschig; Rob Hoeben; Annette Schürmann; Hans-Georg Joost; Hadi Al-Hasani
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity.
Nature genetics 2008;40(11):1354-9.
2008: Jolanda J de Poorter; Rob Hoeben; Wim R Obermann; Tom W J Huizinga; Rob G H H Nelissen
Gene therapy for the treatment of hip prosthesis loosening: adverse events in a phase 1 clinical study.
Human gene therapy 2008;19(10):1029-38.
2008: Ruben Eggers; William Hendriks; Martijn R Tannemaat; Joop J Van Heerikhuize; Chris W Pool; Thomas P Carlstedt; Arnaud Zaldumbide; Rob Hoeben; Gerard J Boer; Joost Verhaagen
Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots.
Molecular and cellular neurosciences 2008;39(1):105-17.
2008: Frederik H E Schagen; Harm C A Graat; Jan E Carette; Jort Vellinga; Michael A van Geer; Rob Hoeben; Terence S Dermody; Victor W van Beusechem
Replacement of native adenovirus receptor-binding sites with a new attachment moiety diminishes hepatic tropism and enhances bioavailability in mice.
Human gene therapy 2008;19(8):783-94.
2008: J de Vrij; taco uil; S K van den Hengel; Steve J Cramer; Danijela Koppers-Lalic; M C Verweij; Emmanuel J H J Wiertz; Jort Vellinga; R A Willemsen; Rob Hoeben
Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX.
Gene therapy 2008;15(13):978-89.
2008: Françoise Carlotti; Arnaud Zaldumbide; Halima Charif; Eelco J de Koning; Theo M Luider; Rob Hoeben
The 45-kDa form of Pdx-1 does not result from post-translational modifications.
Biochemical and biophysical research communications 2008;370(2):225-9.
2008: W J van Houdt; Niels Smakman; Diana J M van den Wollenberg; B L Emmink; Liesbeth M Veenendaal; Paulus van Diest; Rob Hoeben; Inne H M Borel Rinkes; Onno Kranenburg
Transient infection of freshly isolated human colorectal tumor cells by reovirus T3D intermediate subviral particles.
Cancer gene therapy 2008;15(5):284-92.
2008: Mohamed Hamdi; Herman E Popeijus; Françoise Carlotti; Josephine M Janssen; Corina van der Burgt; Paulien Cornelissen-Steijger; Bob van de Water; Rob Hoeben; Koichi Matsuo; Hans van Dam
ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses.
DNA repair 2008;7(3):487-96.
2008: Arnaud Zaldumbide; Rob Hoeben
How not to be seen: immune-evasion strategies in gene therapy.
Gene therapy 2008;15(4):239-46.
2008: Jolanda J de Poorter; Rob Hoeben; Simone Hogendoorn; Vivien Mautner; John Ellis; Wim R Obermann; Tom W J Huizinga; Rob G H H Nelissen
Gene therapy and cement injection for restabilization of loosened hip prostheses.
Human gene therapy 2008;19(1):83-95.
2008: Derrick Louz; Hans E Bergmans; Birgit P Loos; Rob Hoeben
Reappraisal of biosafety risks posed by PERVs in xenotransplantation.
Reviews in medical virology 2008;18(1):53-65.
2007: Maarten ter Horst; Eric Brouwer; Suzanne M Verwijnen; Mark Rodijk; Marion De Jong; Rob Hoeben; Bertie de Leeuw; Peter Sillevis Smitt
Targeting malignant gliomas with a glial fibrillary acidic protein (GFAP)-selective oncolytic adenovirus.
The journal of gene medicine 2007;9(12):1071-9.
2007: Ellen A M Schenk-Braat; Leonie C M Kaptein; Marcella M Hallemeesch; Chris H Bangma; Rob Hoeben
Gene therapy in The Netherlands: highlights from the Low Countries.
The journal of gene medicine 2007;9(10):895-903.
2007: Laura Kakkola; Johanna Tommiska; Linda C L Boele; Simo Miettinen; Tea Blom; Tuija Kekarainen; Jianming Qiu; David J Pintel; Rob Hoeben; Klaus Hedman; Maria Söderlund-Venermo
Construction and biological activity of a full-length molecular clone of human Torque teno virus (TTV) genotype 6.
The FEBS journal 2007;274(18):4719-30.
2007: Jolanda J de Poorter; Kai S Lipinski; Rob G H H Nelissen; Tom W J Huizinga; Rob Hoeben
Optimization of short-term transgene expression by sodium butyrate and ubiquitous chromatin opening elements (UCOEs).
The journal of gene medicine 2007;9(8):639-48.
2007: Martine Ossevoort; Arnaud Zaldumbide; Aartjan J W te Velthuis; Mark Melchers; Maaike E Ressing; Emmanuel J H J Wiertz; Rob Hoeben
The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.
Molecular immunology 2007;44(14):3588-96.
2007: Maria K Magnusson; Petra Henning; Susanna Myhre; Maria Wikman; taco uil; M Friedman; K M E Andersson; Saw See Hong; Rob Hoeben; N A Habib; S Ståhl; Pierre Boulanger; Leif Lindholm
Adenovirus 5 vector genetically re-targeted by an Affibody molecule with specificity for tumor antigen HER2/neu.
Cancer gene therapy 2007;14(5):468-79.
2007: Jort Vellinga; J de Vrij; Susanna Myhre; taco uil; P Martineau; Leif Lindholm; Rob Hoeben
Efficient incorporation of a functional hyper-stable single-chain antibody fragment protein-IX fusion in the adenovirus capsid.
Gene therapy 2007;14(8):664-70.
2007: Eric Brouwer; Menzo J E Havenga; Olga J A E Ophorst; Bertie de Leeuw; L Gijsbers; Gert Gillissen; Rob Hoeben; Maarten ter Horst; Dharmin Nanda; C Dirven; Cees J J Avezaat; Jaap Goudsmit; Peter A E Sillevis Smitt
Human adenovirus type 35 vector for gene therapy of brain cancer: improved transduction and bypass of pre-existing anti-vector immunity in cancer patients.
Cancer gene therapy 2007;14(2):211-9.
2007: Arnaud Zaldumbide; Martine Ossevoort; Emmanuel J H J Wiertz; Rob Hoeben
In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus.
Molecular immunology 2007;44(6):1352-60.
2007: William Hendriks; Ruben Eggers; Thomas P Carlstedt; Arnaud Zaldumbide; Martijn R Tannemaat; Frits J Fallaux; Rob Hoeben; Gerard J Boer; Joost Verhaagen
Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene.
Restorative neurology and neuroscience 2007;25(5-6):585-99.
2007: Heleen Lie-Venema; Nynke M S van den Akker; Noortje A M Bax; Elizabeth M Winter; Saskia Maas; Tuija Kekarainen; Rob Hoeben; Marco C deRuiter; Robert E Poelmann; Adriana C Gittenberger-de Groot
Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development.
TheScientificWorldJournal 2007;7():1777-98.
2006: Vered Raz; Françoise Carlotti; Bart Vermolen; Egge van der Poel; Willem C R Sloos; Shoshan Knaän-Shanzer; Antoine A F de Vries; Rob Hoeben; Ian T Young; Hans J Tanke; Yuval Garini; Roeland W Dirks
Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells.
Journal of cell science 2006;119(Pt 20):4247-56.
2006: Maarten ter Horst; Suzanne M Verwijnen; Eric Brouwer; Rob Hoeben; Marion De Jong; Bertie de Leeuw; Peter A E Sillevis Smitt
Locoregional delivery of adenoviral vectors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(9):1483-9.
2006: Niels Smakman; J D W van der Bilt; Diana J M van den Wollenberg; Rob Hoeben; Inne H M Borel Rinkes; Onno Kranenburg
Immunosuppression promotes reovirus therapy of colorectal liver metastases.
Cancer gene therapy 2006;13(8):815-8.
2006: Martine Ossevoort; Arnaud Zaldumbide; Steve J Cramer; Ellen I H van der Voort; René E M Toes; Rob Hoeben
Characterization of an immuno 'stealth' derivative of the herpes simplex virus thymidine-kinase gene.
Cancer gene therapy 2006;13(6):584-91.
2006: Niels Smakman; Diana J M van den Wollenberg; Sjoerd G Elias; Takehiko Sasazuki; Senji Shirasawa; Rob Hoeben; Inne H M Borel Rinkes; Onno Kranenburg
KRAS(D13) Promotes apoptosis of human colorectal tumor cells by ReovirusT3D and oxaliplatin but not by tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research 2006;66(10):5403-8.
2006: Bertie de Leeuw; Mu Su; Maarten ter Horst; Shingo Iwata; Mark Rodijk; Rob Hoeben; Albee Messing; Peter Sillevis Smitt; Michael Brenner
Increased glia-specific transgene expression with glial fibrillary acidic protein promoters containing multiple enhancer elements.
Journal of neuroscience research 2006;83(5):744-53.
2006: Hendrik J Rademaker; Frits J Fallaux; Diana J M van den Wollenberg; Rob N de Jong; Peter C van der Vliet; Rob Hoeben
Relaxed template specificity in fowl adenovirus 1 DNA replication initiation.
The Journal of general virology 2006;87(Pt 3):553-62.
2006: Jort Vellinga; taco uil; Jeroen de Vrij; Martijn J W E Rabelink; Leif Lindholm; Rob Hoeben
A system for efficient generation of adenovirus protein IX-producing helper cell lines.
The journal of gene medicine 2006;8(2):147-54.
2005: Niels Smakman; Diana J M van den Wollenberg; Inne H M Borel Rinkes; Rob Hoeben; Onno Kranenburg
Sensitization to apoptosis underlies KrasD12-dependent oncolysis of murine C26 colorectal carcinoma cells by reovirus T3D.
Journal of virology 2005;79(23):14981-5.
2005: A Susanne M Zadelaar; Jan H von der Thüsen; Lianne S M Boesten; Rob Hoeben; Mark M Kockx; Marjan A Versnel; Theo Van berkel; Louis M Havekes; Erik A L Biessen; Bart J M van Vlijmen
Increased vulnerability of pre-existing atherosclerosis in ApoE-deficient mice following adenovirus-mediated Fas ligand gene transfer.
Atherosclerosis 2005;183(2):244-50.
2005: Mohamed Hamdi; Jaap Kool; Paulien Cornelissen-Steijger; Françoise Carlotti; Herman E Popeijus; Corina van der Burgt; Josephine M Janssen; Akira Yasui; Rob Hoeben; Carrol Terleth; Leon H F Mullenders; Hans van Dam
DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1.
Oncogene 2005;24(48):7135-44.
2005: Jolanda J de Poorter; Tanja C A Tolboom; Martijn J W E Rabelink; Elsbet Pieterman; Rob Hoeben; Rob G H H Nelissen; Tom W J Huizinga
Towards gene therapy in prosthesis loosening: efficient killing of interface cells by gene-directed enzyme prodrug therapy with nitroreductase and the prodrug CB1954.
The journal of gene medicine 2005;7(11):1421-8.
2005: Derrick Louz; Hans E Bergmans; Birgit P Loos; Rob Hoeben
Cross-species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live-virus vaccines.
The journal of gene medicine 2005;7(10):1263-74.
2005: Graham Bottley; Graham P Cook; Josephine L Meade; John R Holt; Rob Hoeben; G Eric Blair
Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to lymphokine-activated killer (LAK) cells.
Virology 2005;338(2):297-308.
2005: Françoise Carlotti; Arnaud Zaldumbide; Patrick Martin; Kim E Boulukos; Rob Hoeben; Philippe Pognonec
Development of an inducible suicide gene system based on human caspase 8.
Cancer gene therapy 2005;12(7):627-39.
2005: Jort Vellinga; Stephanie Van der Heijdt; Rob Hoeben
The adenovirus capsid: major progress in minor proteins.
The Journal of general virology 2005;86(Pt 6):1581-8.
2005: Merlijn Bazuine; Françoise Carlotti; Martijn J W E Rabelink; Jort Vellinga; Rob Hoeben; J Antonie Maassen
The p38 mitogen-activated protein kinase inhibitor SB203580 reduces glucose turnover by the glucose transporter-4 of 3T3-L1 adipocytes in the insulin-stimulated state.
Endocrinology 2005;146(4):1818-24.
2005: Jort Vellinga; Diana J M van den Wollenberg; Stephanie van der Heijdt; Martijn J W E Rabelink; Rob Hoeben
The coiled-coil domain of the adenovirus type 5 protein IX is dispensable for capsid incorporation and thermostability.
Journal of virology 2005;79(5):3206-10.
2005: Rienk Offringa; Kitty Kwappenberg; Martijn Rabelink; Delphine Rea; Rob Hoeben
Adenoviral transduction of dendritic cells.
Methods in molecular medicine 2005;109():83-96.
2004: Nikita Avvakumov; A E Kajon; Rob Hoeben; Joe S Mymryk
Comprehensive sequence analysis of the E1A proteins of human and simian adenoviruses.
Virology 2004;329(2):477-92.
2004: Delphine Rea; Drake LaFace; Beth Hutchins; Kitty Kwappenberg; Cornelis J M Melief; Rob Hoeben; Rienk Offringa
Recombinant adenovirus-transduced human dendritic cells engineered to secrete interleukin-10 (IL-10) suppress Th1-type responses while selectively activating IL-10-producing CD4+ T cells.
Human immunology 2004;65(11):1344-55.
2004: Merlijn Bazuine; Françoise Carlotti; Roos S Jahangir Tafrechi; Rob Hoeben; J Antonie Maassen
Mitogen-activated protein kinase (MAPK) phosphatase-1 and -4 attenuate p38 MAPK during dexamethasone-induced insulin resistance in 3T3-L1 adipocytes.
Molecular endocrinology (Baltimore, Md.) 2004;18(7):1697-707.
2004: Frederik H E Schagen; Martine Ossevoort; René E M Toes; Rob Hoeben
Immune responses against adenoviral vectors and their transgene products: a review of strategies for evasion.
Critical reviews in oncology/hematology 2004;50(1):51-70.
2004: Jort Vellinga; Martijn J W E Rabelink; Steve J Cramer; Diana J M van den Wollenberg; Hans van der Meulen; Keith Leppard; Frits J Fallaux; Rob Hoeben
Spacers increase the accessibility of peptide ligands linked to the carboxyl terminus of adenovirus minor capsid protein IX.
Journal of virology 2004;78(7):3470-9.
2004: Suzanne M Verwijnen; Peter A E Sillevis Smith; Rob Hoeben; Martin J W E Rabelink; Leonard Wiebe; David T Curiel; Akseli Hemminki; Eric P Krenning; Marion De Jong
Molecular imaging and treatment of malignant gliomas following adenoviral transfer of the herpes simplex virus-thymidine kinase gene and the somatostatin receptor subtype 2 gene.
Cancer biotherapy & radiopharmaceuticals 2004;19(1):111-20.
2004: Françoise Carlotti; Merlijn Bazuine; Tuija Kekarainen; Jurgen Seppen; Philippe Pognonec; J Antonie Maassen; Rob Hoeben
Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;9(2):209-17.
2004: Igor Oruetxebarria; Francesca Venturini; Tuija Kekarainen; Ada Houweling; Lobke M P Zuijderduijn; Adone Mohd-Sarip; Robert G J Vries; Rob Hoeben; C Peter Verrijzer
P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells.
The Journal of biological chemistry 2004;279(5):3807-16.
2004: Marjolijn M van der Eb; Bertie de Leeuw; Alex J van der Eb; Rob Hoeben
Side effects of suicide gene therapy.
Methods in molecular medicine 2004;90():479-90.
2003: Marjolijn M van der Eb; Sacha Geutskens; André B P van Kuilenburg; Henk van Lenthe; Jan Hein van Dierendonck; Peter Kuppen; Hans van Ormondt; Cornelis J H van de Velde; Ronald J A Wanders; Albert H van Gennip; Rob Hoeben
Ganciclovir nucleotides accumulate in mitochondria of rat liver cells expressing the herpes simplex virus thymidine kinase gene.
The journal of gene medicine 2003;5(12):1018-27.
2003: Mohamed A I Abou El Hassan; M J W E Rabelink; Wim J F van der Vijgh; Aalt Bast; Rob Hoeben
A comparative study between catalase gene therapy and the cardioprotector monohydroxyethylrutoside (MonoHER) in protecting against doxorubicin-induced cardiotoxicity in vitro.
British journal of cancer 2003;89(11):2140-6.
2003: Martine Ossevoort; B M J Visser; Diana J M van den Wollenberg; Ellen I H van der Voort; R Offringa; Cornelis J M Melief; René E M Toes; Rob Hoeben
Creation of immune 'stealth' genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1.
Gene therapy 2003;10(24):2020-8.
2003: Leroy R Lard; Floris A van Gaalen; J J M Schonkeren; Elsbet Pieterman; G Stoeken; Koen Vos; Rob G H H Nelissen; Rudi G J Westendorp; Rob Hoeben; Ferdinand C Breedveld; René E M Toes; Tom W J Huizinga
Association of the -2849 interleukin-10 promoter polymorphism with autoantibody production and joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 2003;48(7):1841-8.
2003: Mohamed A I Abou El Hassan; M Heijn; M J W E Rabelink; Wim J F van der Vijgh; Aalt Bast; Rob Hoeben
The protective effect of cardiac gene transfer of CuZn-sod in comparison with the cardioprotector monohydroxyethylrutoside against doxorubicin-induced cardiotoxicity in cultured cells.
Cancer gene therapy 2003;10(4):270-7.
2002: Hendrik J Rademaker; Mohamed A Abou El Hassan; Gijs A Versteeg; Martijn J W E Rabelink; Rob Hoeben
Efficient mobilization of E1-deleted adenovirus type 5 vectors by wild-type adenoviruses of other serotypes.
The Journal of general virology 2002;83(Pt 6):1311-4.
2002: Jan H von der Thüsen; Bart J M van Vlijmen; Rob Hoeben; Mark M Kockx; Louis M Havekes; Theo Van berkel; Erik A L Biessen
Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53.
Circulation 2002;105(17):2064-70.
2002: Marjolijn M van der Eb; Alexandra M Pietersen; Frank M Speetjens; Peter Kuppen; Cornelis J H van de Velde; Mathieu H M Noteborn; Rob Hoeben
Gene therapy with apoptin induces regression of xenografted human hepatomas.
Cancer gene therapy 2002;9(1):53-61.
2001: Delphine Rea; Menzo J E Havenga; M van Den Assem; Roger P M Sutmuller; Angelique A C Lemckert; Rob Hoeben; Abraham Bout; Cornelis J M Melief; Rienk Offringa
Highly efficient transduction of human monocyte-derived dendritic cells with subgroup B fiber-modified adenovirus vectors enhances transgene-encoded antigen presentation to cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(8):5236-44.
2001: Frits J Fallaux; Rob Hoeben
Safety of recombinant adenoviruses produced on adenovirus-transformed human cells.
Developments in biologicals 2001;106():489-96; discussion 497, 501-11.
2001: Peter Kuppen; Marjolijn M van der Eb; Liesbeth E Jonges; Muriel A Hagenaars; Marianne Hokland; Ulf Nannmark; R H Goldfarb; Per H Basse; Gert Jan Fleuren; Rob Hoeben; Cornelis J H van de Velde
Tumor structure and extracellular matrix as a possible barrier for therapeutic approaches using immune cells or adenoviruses in colorectal cancer.
Histochemistry and cell biology 2001;115(1):67-72.
2000: Frederik H E Schagen; Hendrik J Rademaker; Steve J Cramer; Hans van Ormondt; Alex J van der Eb; P van de Putte; Rob Hoeben
Towards integrating vectors for gene therapy: expression of functional bacteriophage MuA and MuB proteins in mammalian cells.
Nucleic acids research 2000;28(23):E104.
2000: Frederik H E Schagen; Hendrik J Rademaker; Martijn J W E Rabelink; Hans van Ormondt; Frits J Fallaux; Alex J van der Eb; Rob Hoeben
Ammonium sulphate precipitation of recombinant adenovirus from culture medium: an easy method to increase the total virus yield.
Gene therapy 2000;7(18):1570-4.
2000: Sacha Geutskens; Marjolijn M van der Eb; A C Plomp; Liesbeth E Jonges; Steve J Cramer; N Geeske Ensink; Peter Kuppen; Rob Hoeben
Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells.
Gene therapy 2000;7(16):1410-6.
2000: Femke de Beer; Ko Willems van Dijk; Miek C Jong; LC van Vark; Anneke van Der Zee; Marten H Hofker; Frits J Fallaux; Rob Hoeben; August Smelt; Louis M Havekes
Apolipoprotein E2 (Lys146-->Gln) causes hypertriglyceridemia due to an apolipoprotein E variant-specific inhibition of lipolysis of very low density lipoproteins-triglycerides.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1800-6.
2000: Heinrich Kovar; Frits J Fallaux; I Pribill; D Jugovic; S Bartl; Peter F Ambros; Dave N T Aryee; J C Wiegant; Rob Hoeben
Adenovirus E1A does not induce the Ewing tumor-associated gene fusion EWS-FLI1.
Cancer research 2000;60(6):1557-60.
2000: Frederik H E Schagen; Hendrik J Rademaker; Frits J Fallaux; Rob Hoeben
Insertion vectors for gene therapy.
Gene therapy 2000;7(4):271-2.
1999: Delphine Rea; Frederik H E Schagen; Rob Hoeben; M Mehtali; Menzo J E Havenga; René E M Toes; Cornelis J M Melief; Rienk Offringa
Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset.
Journal of virology 1999;73(12):10245-53.
1999: Alexandra M Pietersen; Marjolijn M van der Eb; Hendrik J Rademaker; Diana J M van den Wollenberg; Martijn J W E Rabelink; Peter Kuppen; Jan Hein van Dierendonck; Hans van Ormondt; D Masman; Cornelis J H van de Velde; Alex J van der Eb; Rob Hoeben; Mathieu H M Noteborn
Specific tumor-cell killing with adenovirus vectors containing the apoptin gene.
Gene therapy 1999;6(5):882-92.
1999: Frederik H E Schagen; Anne Moor; S C Cheong; Steve J Cramer; Hans van Ormondt; Alex J van der Eb; Tom M A R Dubbelman; Rob Hoeben
Photodynamic treatment of adenoviral vectors with visible light: an easy and convenient method for viral inactivation.
Gene therapy 1999;6(5):873-81.
1999: Frits J Fallaux; Alex J van der Eb; Rob Hoeben
Who's afraid of replication-competent adenoviruses?
Gene therapy 1999;6(5):709-12.
1998: Frits J Fallaux; Abraham Bout; Ietje van der Velde; Diana J M van den Wollenberg; K M Hehir; J Keegan; C Auger; Steve J Cramer; Hans van Ormondt; Alex J van der Eb; Dinko Valerio; Rob Hoeben
New helper cells and matched early region 1-deleted adenovirus vectors prevent generation of replication-competent adenoviruses.
Human gene therapy 1998;9(13):1909-17.
1998: Marjolijn M van der Eb; Frederik H E Schagen; Hans van Ormondt; Rob Hoeben
[Gene therapy for hemophilia: feasible in principle but not yet clinically applicable].
Nederlands tijdschrift voor geneeskunde 1998;142(15):840-4.
1998: Marjolijn M van der Eb; Steve J Cramer; Y Vergouwe; Frederik H E Schagen; J H van Krieken; Alex J van der Eb; I H Borel Rinkes; Cornelis J H van de Velde; Rob Hoeben
Severe hepatic dysfunction after adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene and ganciclovir administration.
Gene therapy 1998;5(4):451-8.
1998: Marjolijn M van der Eb; Rob Hoeben; Cornelis J H van de Velde
Towards gene therapy for colorectal liver metastases.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;147():173-86.
1997: René E M Toes; Rob Hoeben; Ellen I H van der Voort; Maaike E Ressing; A J van der Eb; Cornelis J M Melief; Rienk Offringa
Protective anti-tumor immunity induced by vaccination with recombinant adenoviruses encoding multiple tumor-associated cytotoxic T lymphocyte epitopes in a string-of-beads fashion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(26):14660-5.
1997: Rob Hoeben; Frits J Fallaux; Frederik H E Schagen; Marjolijn M van der Eb; Hans van Ormondt; Alex J van der Eb
Factors impeding efficient expression of factor VIII complementary DNA minigenes.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8 Suppl 2():S15-21.
1997: René E M Toes; Stephen P Schoenberger; Ellen I H van der Voort; W Martin Kast; Rob Hoeben; Cornelis J M Melief; Rienk Offringa
Activation or frustration of anti-tumor responses by T-cell-based immune modulation.
Seminars in immunology 1997;9(5):323-7.
1997: W K de Roos; Frits J Fallaux; A W Marinelli; A Lazaris-Karatzas; A B von Geusau; Marjolijn M van der Eb; Steve J Cramer; Onno T Terpstra; Rob Hoeben
Isolated-organ perfusion for local gene delivery: efficient adenovirus-mediated gene transfer into the liver.
Gene therapy 1997;4(1):55-62.
1996: Frits J Fallaux; Rob Hoeben
Gene therapy for the hemophilias.
Current opinion in hematology 1996;3(5):385-9.
1996: Frits J Fallaux; Rob Hoeben; Steve J Cramer; Diana J M van den Wollenberg; E Briët; Hans van Ormondt; Alex J van der Eb
The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of sodium butyrate.
Molecular and cellular biology 1996;16(8):4264-72.
1996: P A Roest; A C van der Tuijn; HB Ginjaar; Rob Hoeben; F B Hoger-Vorst; Egbert Bakker; Johan T den Dunnen; Gert-Jan B van Ommen
Application of in vitro Myo-differentiation of non-muscle cells to enhance gene expression and facilitate analysis of muscle proteins.
Neuromuscular disorders : NMD 1996;6(3):195-202.
1996: Frits J Fallaux; Onno Kranenburg; Steve J Cramer; A Houweling; Hans van Ormondt; Rob Hoeben; Alex J van der Eb
Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.
Human gene therapy 1996;7(2):215-22.
1995: Frits J Fallaux; Rob Hoeben; E Briët
State and prospects of gene therapy for the hemophilias.
Thrombosis and haemostasis 1995;74(1):266-73.
1995: Rob Hoeben; Frits J Fallaux; Steve J Cramer; Diana J M van den Wollenberg; Hans van Ormondt; E Briët; Alex J van der Eb
Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region.
Blood 1995;85(9):2447-54.
1995: Rob Hoeben
Gene therapy for the haemophilias: current status.
Biologicals : journal of the International Association of Biological Standardization 1995;23(1):27-9.
1994: Diana J M van den Wollenberg; Rob Hoeben; Hans van Ormondt; Alex J van der Eb
Insertion of the human cytomegalovirus enhancer into a myeloproliferative sarcoma virus long terminal repeat creates a high-expression retroviral vector.
Gene 1994;144(2):237-41.
1993: Rob Hoeben; Frits J Fallaux; N H Van Tilburg; Steve J Cramer; Hans van Ormondt; E Briët; Alex J van der Eb
Toward gene therapy for hemophilia A: long-term persistence of factor VIII-secreting fibroblasts after transplantation into immunodeficient mice.
Human gene therapy 1993;4(2):179-86.
1992: Rob Hoeben; Dinko Valerio; Alex J van der Eb; Hans van Ormondt
Gene therapy for human inherited disorders: techniques and status.
Critical reviews in oncology/hematology 1992;13(1):33-54.
1992: E Ben-Hur; Rob Hoeben; Hans van Ormondt; Tom M A R Dubbelman; J Van Steveninck
Photodynamic inactivation of retroviruses by phthalocyanines: the effects of sulphonation, metal ligand and fluoride.
Journal of photochemistry and photobiology. B, Biology 1992;13(2):145-52.
1992: Rob Hoeben; Mark Einerhand; E Briët; Hans van Ormondt; Dinko Valerio; Alex J van der Eb
Toward gene therapy in haemophilia A: retrovirus-mediated transfer of a factor VIII gene into murine haematopoietic progenitor cells.
Thrombosis and haemostasis 1992;67(3):341-5.
1991: Mathieu H M Noteborn; G F de Boer; D J van Roozelaar; C Karreman; Onno Kranenburg; J G Vos; Suzan H M Jeurissen; Rob Hoeben; Alt Zantema; G Koch
Characterization of cloned chicken anemia virus DNA that contains all elements for the infectious replication cycle.
Journal of virology 1991;65(6):3131-9.
1991: Rob Hoeben; A A Migchielsen; R C van der Jagt; Hans van Ormondt; Alex J van der Eb
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
Journal of virology 1991;65(2):904-12.
1990: Rob Hoeben; R C van der Jagt; F Schoute; N H van Tilburg; M P Verbeet; E Briët; Hans van Ormondt; Alex J van der Eb
Expression of functional factor VIII in primary human skin fibroblasts after retrovirus-mediated gene transfer.
The Journal of biological chemistry 1990;265(13):7318-23.
1989: H L Vos; D E Brough; F M Van der Lee; Rob Hoeben; G F Verheijden; D Dooijes; Daniel F Klessig; John S Sussenbach
Characterization of adenovirus type 5 insertion and deletion mutants encoding altered DNA binding proteins.
Virology 1989;172(2):634-42.
1987: R A Warringa; Rob Hoeben; J W Koper; J E Sykes; Lambert M G van Golde; M Lopes-Cardozo
Hydrocortisone stimulates the development of oligodendrocytes in primary glial cultures and affects glucose metabolism and lipid synthesis in these cultures.
Brain research 1987;431(1):79-86.
1986: J W Koper; Rob Hoeben; F M Hochstenbach; Lambert M G van Golde; M Lopes-Cardozo
Effects of triiodothyronine on the synthesis of sulfolipids by oligodendrocyte-enriched glial cultures.
Biochimica et biophysica acta 1986;887(3):327-34.