FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Andrew Ayrton

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

Physiology

Procedures

Mutagenicity Tests

Co-author Network

Publications

TOP 3
Melanie Z Sakatis; Maxine A Taylor; Eric Y Yang; Jeffrey L Ambroso; Andrew Ayrton; Ian A Baines; Jackie C Bloomer; Liangfu Chen; Harma M Ellens; Andrew W Harrell; Cerys A Lovatt; Melinda J Reese; Stephen E Clarke
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Ziqiang Cheng; Chen-bing Guan; Houfu Liu; Qian Liu; Fei Wang; Yan Xu; Na Yu; Gang An; Andrew Ayrton
Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier.
Melinda Reese; Melanie Sakatis; Jeffrey Ambroso; Andrew Harrell; Eric Yang; Liangfu Chen; Maxine Taylor; Ian Baines; Lei Zhu; Andrew Ayrton; Stephen Clarke
An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Andrew Ayrton (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Melanie Z Sakatis; Maxine A Taylor; Eric Y Yang; Jeffrey L Ambroso; Andrew Ayrton; Ian A Baines; Jackie C Bloomer; Liangfu Chen; Harma M Ellens; Andrew W Harrell; Cerys A Lovatt; Melinda J Reese; Stephen E Clarke
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Chemical research in toxicology 2012;25(10):2067-82.
2012: Ziqiang Cheng; Chen-bing Guan; Houfu Liu; Qian Liu; Fei Wang; Yan Xu; Na Yu; Gang An; Andrew Ayrton
Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier.
Xenobiotica; the fate of foreign compounds in biological systems 2012;42(9):880-90.
2011: Melinda Reese; Melanie Sakatis; Jeffrey Ambroso; Andrew Harrell; Eric Yang; Liangfu Chen; Maxine Taylor; Ian Baines; Lei Zhu; Andrew Ayrton; Stephen Clarke
An integrated reactive metabolite evaluation approach to assess and reduce safety risk during drug discovery and development.
Chemico-biological interactions 2011;192(1-2):60-4.
2010: Annie Albin Lumen; Poulomi Acharya; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
If the KI is defined by the free energy of binding to P-glycoprotein, which kinetic parameters define the IC50 for the Madin-Darby canine kidney II cell line overexpressing human multidrug resistance 1 confluent cell monolayer?
Drug metabolism and disposition: the biological fate of chemicals 2010;38(2):260-9.
2009: Victoria E Thiel-Demby; Joan E Humphreys; Lisa A St John Williams; Harma M Ellens; Nipa Shah; Andrew Ayrton; Joseph W Polli
Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay.
Molecular pharmaceutics 2009;6(1):11-8.
2008: Dorien Groenendaal; Jan Freijer; Andrea Rosier; Dennis de Mik; Glynis Nicholls; Anne Hersey; Andrew Ayrton; Meindert Danhof; Elizabeth C M de Lange
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008;34(2-3):149-63.
2008: Andrew Ayrton; P Morgan
Role of transport proteins in drug discovery and development: a pharmaceutical perspective.
Xenobiotica; the fate of foreign compounds in biological systems 2008;38(7-8):676-708.
2008: Poulomi Acharya; Michael P O'Connor; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(2):452-60.
2006: Poulomi Acharya; Thuy T Tran; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
P-Glycoprotein (P-gp) expressed in a confluent monolayer of hMDR1-MDCKII cells has more than one efflux pathway with cooperative binding sites.
Biochemistry 2006;45(51):15505-19.
2006: Sandra J Baldwin; Jo L Bramhall; Charlotte A Ashby; Lin Yue; Paul R Murdock; Steven Hood; Andrew Ayrton; Stephen E Clarke
Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).
Drug metabolism and disposition: the biological fate of chemicals 2006;34(6):1063-9.
2005: Joe Bentz; Thuy Thanh Tran; Joseph W Polli; Andrew Ayrton; Harma Ellens
The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.
Pharmaceutical research 2005;22(10):1667-77.
2005: Tom D Heightman; Laramie M Gaster; Sarah L Pardoe; Jean-Pierre Pilleux; Michael S Hadley; Derek N Middlemiss; Gary W Price; Claire Roberts; Claire M Scott; Jeannette M Watson; Laurie J Gordon; Vicky Holland; Jenifer Powles; Graham J Riley; Tania O Stean; Brenda K Trail; Neil Upton; Nigel E Austin; Andrew Ayrton; Tanya Coleman; Leanne Cutler
8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.
Bioorganic & medicinal chemistry letters 2005;15(19):4370-4.
2005: Kevin J Spears; Jillian Ross; Alasdair Stenhouse; Clive J Ward; Lay-Beng Goh; C Roland Wolf; Paul Morgan; Andrew Ayrton; Thomas Friedberg
Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.
Biochemical pharmacology 2005;69(3):415-23.
2005: Thuy Thanh Tran; Aditya Mittal; Tanya Aldinger; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
The elementary mass action rate constants of P-gp transport for a confluent monolayer of MDCKII-hMDR1 cells.
Biophysical journal 2005;88(1):715-38.
2004: Thuy Thanh Tran; Aditya Mittal; Tracy Gales; Beverly Maleeff; Tanya Aldinger; Joseph W Polli; Andrew Ayrton; Harma Ellens; Joe Bentz
Exact kinetic analysis of passive transport across a polarized confluent MDCK cell monolayer modeled as a single barrier.
Journal of pharmaceutical sciences 2004;93(8):2108-23.
2003: KE Swales; Nick Plant; Andrew Ayrton; Steven Hood; Gordon Gibson
Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(7):703-16.
2002: Lay Beng Goh; Kevin J Spears; Denggao Yao; Andrew Ayrton; Paul Morgan; C Roland Wolf; Thomas Friedberg
Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.
Biochemical pharmacology 2002;64(11):1569-78.
2002: G Gordon Gibson; Nick Plant; KE Swales; Andrew Ayrton; Wafaa El-Sankary
Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(3):165-206.
2001: Y Y Deeni; Mark Paine; Andrew Ayrton; S E Clarke; RJ Chenery; C Roland Wolf
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein.
Archives of biochemistry and biophysics 2001;396(1):16-24.
2001: Wafaa El-Sankary; G Gordon Gibson; Andrew Ayrton; Nick Plant
Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(11):1499-504.
2001: Nigel E Austin; S J Baldwin; Leanne Cutler; Nigel J Deeks; P J Kelly; M Nash; C E Shardlow; Geoffrey Stemp; Kevin M Thewlis; Andrew Ayrton; Phillip Jeffrey
Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(8-9):677-86.
2001: Andrew Ayrton; P Morgan
Role of transport proteins in drug absorption, distribution and excretion.
Xenobiotica; the fate of foreign compounds in biological systems 2001;31(8-9):469-97.
1998: Jerry L Adams; Jeffrey C Boehm; Shouki Kassis; PD Gorycki; Edward F Webb; R Hall; M Sorenson; John Lee; Andrew Ayrton; Don E Griswold; TF Gallagher
Pyrimidinylimidazole inhibitors of CSBP/p38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes.
Bioorganic & medicinal chemistry letters 1998;8(22):3111-6.
1998: P R Tiller; A P Land; I Jardine; D M Murphy; R Sozio; Andrew Ayrton; W H Schaefer
Application of liquid chromatography-mass spectrometry(n) analyses to the characterization of novel glyburide metabolites formed in vitro.
Journal of chromatography. A 1998;794(1-2):15-25.
1995: S J Baldwin; J C Bloomer; G J Smith; Andrew Ayrton; Stephen E Clarke; R J Chenery
Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(3):261-70.
1994: J C Bloomer; S J Baldwin; G J Smith; Andrew Ayrton; Stephen E Clarke; R J Chenery
Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron.
British journal of clinical pharmacology 1994;38(6):557-66.
1994: Stephen E Clarke; S J Baldwin; J C Bloomer; Andrew Ayrton; R S Sozio; R J Chenery
Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes.
Chemical research in toxicology 1994;7(6):836-42.
1994: Stephen E Clarke; Andrew Ayrton; R J Chenery
Characterization of the inhibition of P4501A2 by furafylline.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(6):517-26.
1993: Costas Ioannides; Andrew Ayrton; David F V Lewis; R Walker
Extrapolation of in vitro antimutagenicity to the in vivo situation: the case for anthraflavic acid.
Basic life sciences 1993;61():103-10.
1992: Andrew Ayrton; David F V Lewis; R Walker; Costas Ioannides
Antimutagenicity of ellagic acid towards the food mutagen IQ: investigation into possible mechanisms of action.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(4):289-95.
1992: M Leist; Andrew Ayrton; Costas Ioannides
A cytosolic oxygenase activity involved in the bioactivation of 2-aminofluorene.
Toxicology 1992;71(1-2):7-20.
1992: Andrew Ayrton; S Neville; Costas Ioannides
Cytosolic activation of 2-aminoanthracene: implications in its use as diagnostic mutagen in the Ames test.
Mutation research 1992;265(1):1-8.
1991: Andrew Ayrton; Costas Ioannides; Dennis V Parke
Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity.
Biochemical pharmacology 1991;42(1):109-15.
1990: Costas Ioannides; Andrew Ayrton; A Keele; David F V Lewis; Peter R Flatt; R Walker
Mechanism of the in vitro antimutagenic action of retinol.
Mutagenesis 1990;5(3):257-62.
1990: Andrew Ayrton; M McFarlane; R Walker; S Neville; Costas Ioannides
The induction of P450 I proteins by aromatic amines may be related to their carcinogenic potential.
Carcinogenesis 1990;11(5):803-9.
1990: J N Smith; Andrew Ayrton; J Chown; David F V Lewis; Costas Ioannides
Feprazone: an inducer of the P450 II B family of proteins in the rat.
Journal of biochemical toxicology 1990;5(1):9-12.
1990: Andrew Ayrton; M McFarlane; R Walker; S Neville; MM Coombs; Costas Ioannides
Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: possible relationship to their carcinogenicity.
Toxicology 1990;60(1-2):173-86.
1989: Costas Ioannides; A D Rodrigues; Andrew Ayrton; C R Barnett; J Chown; Dennis V Parke
Induction of the rat hepatic microsomal mixed-function oxidases by cimetidine.
Toxicology letters 1989;49(1):61-8.
1989: A D Rodrigues; Andrew Ayrton; E J Williams; David F V Lewis; R Walker; Costas Ioannides
Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline.
European journal of biochemistry / FEBS 1989;181(3):627-31.
1989: Andrew Ayrton; E J Williams; A D Rodrigues; Costas Ioannides; R Walker
The food pyrolysis product IQ enhances its own activation.
Mutagenesis 1989;4(3):205-7.
1989: Peter R Flatt; S L Bass; Andrew Ayrton; J Trinick; Costas Ioannides
Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
Diabetologia 1989;32(2):135-9.
1988: Andrew Ayrton; J Trinick; B P Wood; J N Smith; Costas Ioannides
Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes. A comparison with their non-heterocyclic analogues.
Biochemical pharmacology 1988;37(23):4565-71.
1988: Andrew Ayrton; Costas Ioannides; R Walker
Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(11-12):909-15.
1988: R J Chenery; Andrew Ayrton; H G Oldham; S J Norman; P Standring
The interaction of omeprazole with rat liver cytochrome P450-mediated monooxygenase reactions in vitro and in vivo.
Biochemical pharmacology 1988;37(7):1407-14.
1988: Andrew Ayrton; Costas Ioannides; R Walker
Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action.
Mutation research 1988;207(3-4):121-5.
1988: Costas Ioannides; S L Bass; Andrew Ayrton; J Trinick; R Walker; Peter R Flatt
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Chemico-biological interactions 1988;68(3-4):189-202.
1987: Andrew Ayrton; David F V Lewis; Costas Ioannides; R Walker
Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity.
Biochimica et biophysica acta 1987;916(3):328-31.
1987: Andrew Ayrton; J N Smith; Costas Ioannides
Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction.
Carcinogenesis 1987;8(11):1691-5.
1987: R J Chenery; Andrew Ayrton; H G Oldham; P Standring; S J Norman; T Seddon; R Kirby
Diazepam metabolism in cultured hepatocytes from rat, rabbit, dog, guinea pig, and man.
Drug metabolism and disposition: the biological fate of chemicals 1987;15(3):312-7.