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Paul Tulkens

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Anatomy

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Microbial Sensitivity Tests

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Hydrogen-Ion Concentration

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Co-Publications
Name
74
Van Bambeke, Françoise
60
Mingeot-Leclercq, Marie-Paule
24
Laurent, Guy
14
Lemaire, Sandrine
12
Brasseur, Robert
10
Carryn, Stéphane
10
Heuson-Stiennon, JA
10
Toubeau, Gérard
9
Chanteux, Hugues
8
Schanck, André
8
Seral, Cristina
7
Michot, Jean-Michel
7
Glupczynski, Youri
6
Servais, Hélène
5
Nonclercq, Denis

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Publications

TOP 3
Berthoin Karine; Ampe Els; Tulkens Paul M; Carryn Stephane
Correlation between free and total vancomycin serum concentrations in patients treated for Gram-positive infections.
Olivier Aurélie C; Lemaire Sandrine; Van Bambeke Françoise; Tulkens Paul M; Oldfield Eric
Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.
Lemaire Sandrine; Van Bambeke Françoise; Appelbaum Peter C; Tulkens Paul M
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.

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All Publications

2009: Berthoin Karine; Ampe Els; Tulkens Paul M; Carryn Stephane
Correlation between free and total vancomycin serum concentrations in patients treated for Gram-positive infections.
International journal of antimicrobial agents 2009;34(6):555-60.
2009: Olivier Aurélie C; Lemaire Sandrine; Van Bambeke Françoise; Tulkens Paul M; Oldfield Eric
Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells.
The Journal of infectious diseases 2009;200(9):1367-70.
2009: Lemaire Sandrine; Van Bambeke Françoise; Appelbaum Peter C; Tulkens Paul M
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.
The Journal of antimicrobial chemotherapy 2009;64(5):1035-43.
2009: Brinch Karoline Sidelmann; Sandberg Anne; Baudoux Pierre; Van Bambeke Françoise; Tulkens Paul M; Frimodt-Møller Niels; Høiby Niels; Kristensen Hans-Henrik
Plectasin shows intracellular activity against Staphylococcus aureus in human THP-1 monocytes and in a mouse peritonitis model.
Antimicrobial agents and chemotherapy 2009;53(11):4801-8.
2009: Lemaire Sandrine; Van Bambeke Françoise; Tulkens Paul M
Cellular accumulation and pharmacodynamic evaluation of the intracellular activity of CEM-101, a novel fluoroketolide, against Staphylococcus aureus, Listeria monocytogenes, and Legionella pneumophila in human THP-1 macrophages.
Antimicrobial agents and chemotherapy 2009;53(9):3734-43.
2009: Domenech Oscar; Francius Grégory; Tulkens Paul M; Van Bambeke Françoise; Dufrêne Yves; Mingeot-Leclercq Marie-Paule
Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization.
Biochimica et biophysica acta 2009;1788(9):1832-40.
2009: Van Bambeke F; Tulkens P M
[Pharmacodynamics of antibiotics in CSF: principles and consequences (predictive factors of efficacy)]
Médecine et maladies infectieuses 2009;39(7-8):483-92.
2009: Marquez Béatrice; Caceres Nancy E; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
Antimicrobial agents and chemotherapy 2009;53(6):2410-6.
2009: Lemaire Sandrine; Glupczynski Youri; Duval Valérie; Joris Bernard; Tulkens Paul M; Van Bambeke Françoise
Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2009;53(6):2289-97.
2009: Nguyen Hoang Anh; Denis Olivier; Vergison Anne; Tulkens Paul M; Struelens Marc J; Van Bambeke Françoise
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: study of antibiotic combinations.
Antimicrobial agents and chemotherapy 2009;53(4):1443-9.
2009: Nguyen Hoang Anh; Denis Olivier; Vergison Anne; Theunis Anne; Tulkens Paul M; Struelens Marc J; Van Bambeke Françoise
Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: pharmacodynamic evaluation and comparison with isogenic normal-phenotype and revertant strains.
Antimicrobial agents and chemotherapy 2009;53(4):1434-42.
2009: Livermore David M; Tulkens Paul M
Temocillin revived.
The Journal of antimicrobial chemotherapy 2009;63(2):243-5.
2009: Feron J M; Legrand D; Pestiaux D; Tulkens P
[Antibiotic use in general practice in Belgium and France: between collective factors and individual responsibility]
Pathologie-biologie 2009;57(1):61-4.
2009: Tytgat I; Colacino E; Tulkens P M; Poupaert J H; Prévost M; Van Bambeke F
DD-ligases as a potential target for antibiotics: past, present and future.
Current medicinal chemistry 2009;16(20):2566-80.
2009: Van Bambeke Françoise; Tulkens Paul M
Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes.
Drug safety : an international journal of medical toxicology and drug experience 2009;32(5):359-78.
2009: Becker Jean-Paul; Depret Grégoire; Van Bambeke Françoise; Tulkens Paul M; Prévost Martine
Molecular models of human P-glycoprotein in two different catalytic states.
BMC structural biology 2009;9():3.
2008: Bensikaddour Hayet; Snoussi Karim; Lins Laurence; Van Bambeke Françoise; Tulkens Paul M; Brasseur Robert; Goormaghtigh Erik; Mingeot-Leclercq Marie-Paule
Interactions of ciprofloxacin with DPPC and DPPG: fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis.
Biochimica et biophysica acta 2008;1778(11):2535-43.
2008: Lismond Ann; Tulkens Paul M; Mingeot-Leclercq Marie-Paule; Courvalin Patrice; Van Bambeke Françoise
Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes: studies with ciprofloxacin and moxifloxacin.
Antimicrobial agents and chemotherapy 2008;52(9):3040-6.
2008: Van de Velde Sébastien; Nguyen Hoang Anh; Van Bambeke Françoise; Tulkens Paul M; Grellet Jean; Dubois Véronique; Quentin Claudine; Saux Marie-Claude
Contrasting effects of human THP-1 cell differentiation on levofloxacin and moxifloxacin intracellular accumulation and activity against Staphylococcus aureus and Listeria monocytogenes.
The Journal of antimicrobial chemotherapy 2008;62(3):518-21.
2008: Lemaire S; Kosowska-Shick K; Julian K; Tulkens P M; Van Bambeke F; Appelbaum P C
Activities of antistaphylococcal antibiotics towards the extracellular and intraphagocytic forms of Staphylococcus aureus isolates from a patient with persistent bacteraemia and endocarditis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2008;14(8):766-77.
2008: Lemaire Sandrine; Olivier Aurélie; Van Bambeke Françoise; Tulkens Paul M; Appelbaum Peter C; Glupczynski Youri
Restoration of susceptibility of intracellular methicillin-resistant Staphylococcus aureus to beta-lactams: comparison of strains, cells, and antibiotics.
Antimicrobial agents and chemotherapy 2008;52(8):2797-805.
2008: Denamur Sophie; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.
Antimicrobial agents and chemotherapy 2008;52(6):2236-8.
2008: Barcia-Macay Maritza; Mouaden Fatima; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Cellular pharmacokinetics of telavancin, a novel lipoglycopeptide antibiotic, and analysis of lysosomal changes in cultured eukaryotic cells (J774 mouse macrophages and rat embryonic fibroblasts).
The Journal of antimicrobial chemotherapy 2008;61(6):1288-94.
2008: Lemaire Sandrine; Fuda Cosimo; Van Bambeke Françoise; Tulkens Paul M; Mobashery Shahriar
Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to beta-lactam antibiotics by acidic pH: role of penicillin-binding protein PBP 2a.
The Journal of biological chemistry 2008;283(19):12769-76.
2008: Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Struelens Marc J; Tulkens Paul M
The bacterial envelope as a target for novel anti-MRSA antibiotics.
Trends in pharmacological sciences 2008;29(3):124-34.
2008: Van Bambeke Françoise; Harms Joerg M; Van Laethem Yves; Tulkens Paul M
Ketolides: pharmacological profile and rational positioning in the treatment of respiratory tract infections.
Expert opinion on pharmacotherapy 2008;9(2):267-83.
2008: De Jongh Raf; Hens Ria; Basma Violetta; Mouton Johan W; Tulkens Paul M; Carryn Stéphane
Continuous versus intermittent infusion of temocillin, a directed spectrum penicillin for intensive care patients with nosocomial pneumonia: stability, compatibility, population pharmacokinetic studies and breakpoint selection.
The Journal of antimicrobial chemotherapy 2008;61(2):382-8.
2008: Mouton Johan W; Theuretzbacher Ursula; Craig William A; Tulkens Paul M; Derendorf Hartmut; Cars Otto
Tissue concentrations: do we ever learn?
The Journal of antimicrobial chemotherapy 2008;61(2):235-7.
2008: Servais H; Ortiz A; Devuyst O; Denamur S; Tulkens P M; Mingeot-Leclercq M-P
Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation.
Apoptosis : an international journal on programmed cell death 2008;13(1):11-32.
2007: Hernout Olivier; Berthoin Karine; Delattre Isabelle; Tulkens Paul M; Carryn Stéphane; Marchand-Brynaert Jacqueline
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif L-Lys-D-Ala-D-Ala for use in a vancomycin biosensor.
Bioorganic & medicinal chemistry letters 2007;17(21):5758-62.
2007: Avrain Laetitia; Garvey Mark; Mesaros Narcisa; Glupczynski Youri; Mingeot-Leclercq Marie-Paule; Piddock Laura J V; Tulkens Paul M; Vanhoof Raymond; Van Bambeke Françoise
Selection of quinolone resistance in Streptococcus pneumoniae exposed in vitro to subinhibitory drug concentrations.
The Journal of antimicrobial chemotherapy 2007;60(5):965-72.
2007: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.
Antimicrobial agents and chemotherapy 2007;51(8):2748-57.
2007: Mesaros N; Nordmann P; Plésiat P; Roussel-Delvallez M; Van Eldere J; Glupczynski Y; Van Laethem Y; Jacobs F; Lebecque P; Malfroot A; Tulkens P M; Van Bambeke F
Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2007;13(6):560-78.
2007: Spinewine Anne; Swine Christian; Dhillon Soraya; Lambert Philippe; Nachega Jean B; Wilmotte Léon; Tulkens Paul M
Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial.
Journal of the American Geriatrics Society 2007;55(5):658-65.
2007: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Glupczynski Youri; Tulkens Paul M
Role of acidic pH in the susceptibility of intraphagocytic methicillin-resistant Staphylococcus aureus strains to meropenem and cloxacillin.
Antimicrobial agents and chemotherapy 2007;51(5):1627-32.
2007: Mesaros Narcisa; Glupczynski Youri; Avrain Laëtitia; Caceres Nancy E; Tulkens Paul M; Van Bambeke Françoise
A combined phenotypic and genotypic method for the detection of Mex efflux pumps in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy 2007;59(3):378-86.
2007: Baudoux Pierre; Bles Nathalie; Lemaire Sandrine; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Combined effect of pH and concentration on the activities of gentamicin and oxacillin against Staphylococcus aureus in pharmacodynamic models of extracellular and intracellular infections.
The Journal of antimicrobial chemotherapy 2007;59(2):246-53.
2007: Van Bambeke Françoise; Reinert René R; Appelbaum Peter C; Tulkens Paul M; Peetermans Willy E
Multidrug-resistant Streptococcus pneumoniae infections: current and future therapeutic options.
Drugs 2007;67(16):2355-82.
2006: Barcia-Macay Maritza; Lemaire Sandrine; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Evaluation of the extracellular and intracellular activities (human THP-1 macrophages) of telavancin versus vancomycin against methicillin-susceptible, methicillin-resistant, vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2006;58(6):1177-84.
2006: Michot Jean-Michel; Heremans Marie F; Caceres Nancy E; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Cellular accumulation and activity of quinolones in ciprofloxacin-resistant J774 macrophages.
Antimicrobial agents and chemotherapy 2006;50(5):1689-95.
2006: Vandevuer Stéphane; Van Bambeke Françoise; Tulkens Paul M; Prévost Martine
Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: insight into the mechanism of ligand migration and binding sites.
Proteins 2006;63(3):466-78.
2006: Servais Hélène; Jossin Yves; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.
Antimicrobial agents and chemotherapy 2006;50(4):1213-21.
2006: Spinewine Anne; Dhillon Soraya; Mallet Louise; Tulkens Paul M; Wilmotte Léon; Swine Christian
Implementation of ward-based clinical pharmacy services in Belgium--description of the impact on a geriatric unit.
The Annals of pharmacotherapy 2006;40(4):720-8.
2006: Van Bambeke Françoise; Barcia-Macay Maritza; Lemaire Sandrine; Tulkens Paul M
Cellular pharmacodynamics and pharmacokinetics of antibiotics: current views and perspectives.
Current opinion in drug discovery & development 2006;9(2):218-30.
2006: Barcia-Macay Maritza; Seral Cristina; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Pharmacodynamic evaluation of the intracellular activities of antibiotics against Staphylococcus aureus in a model of THP-1 macrophages.
Antimicrobial agents and chemotherapy 2006;50(3):841-51.
2006: Charvalos Ekatherina; Tzatzarakis Manolis N; Van Bambeke Françoise; Tulkens Paul M; Tsatsakis Aristidis M; Tzanakakis George N; Mingeot-Leclercq Marie-Paule
Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced haemolytic and cytotoxic effects.
The Journal of antimicrobial chemotherapy 2006;57(2):236-44.
2005: Spinewine Anne; Swine Christian; Dhillon Soraya; Franklin Bryony Dean; Tulkens Paul M; Wilmotte Léon; Lorant Vincent
Appropriateness of use of medicines in elderly inpatients: qualitative study.
BMJ (Clinical research ed.) 2005;331(7522):935.
2005: Servais Hélène; Van Der Smissen Patrick; Thirion Gaëtan; Van der Essen Gauthier; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria.
Toxicology and applied pharmacology 2005;206(3):321-33.
2005: Michot Jean-Michel; Seral Cristina; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Influence of efflux transporters on the accumulation and efflux of four quinolones (ciprofloxacin, levofloxacin, garenoxacin, and moxifloxacin) in J774 macrophages.
Antimicrobial agents and chemotherapy 2005;49(6):2429-37.
2005: Lemaire Sandrine; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Activity of three {beta}-lactams (ertapenem, meropenem and ampicillin) against intraphagocytic Listeria monocytogenes and Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2005;55(6):897-904.
2005: Van Bambeke Françoise; Saffran Jennifer; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation.
Antimicrobial agents and chemotherapy 2005;49(5):1695-700.
2005: Chanteux Hugues; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Accumulation and oriented transport of ampicillin in Caco-2 cells from its pivaloyloxymethylester prodrug, pivampicillin.
Antimicrobial agents and chemotherapy 2005;49(4):1279-88.
2005: Van Bambeke F; Michot J-M; Van Eldere J; Tulkens P M
Quinolones in 2005: an update.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2005;11(4):256-80.
2005: Seral C; Barcia-Macay M; Mingeot-Leclercq M P; Tulkens P M; Van Bambeke F
Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.
The Journal of antimicrobial chemotherapy 2005;55(4):511-7.
2005: Piret Jocelyne; Schanck André; Delfosse Sylvie; Van Bambeke Françoise; Kishore Bellamkonda K; Tulkens Paul M; Mingeot-Leclercq Marie-Paule
Modulation of the in vitro activity of lysosomal phospholipase A1 by membrane lipids.
Chemistry and physics of lipids 2005;133(1):1-15.
2004: Bauraind Isabelle; Lopez-Lozano José-Maria; Beyaert Arielle; Marchal Jean-Louis; Seys Bruno; Yane Fernande; Hendrickx Erik; Goossens Herman; Tulkens Paul M; Verbist Ludo
Association between antibiotic sales and public campaigns for their appropriate use.
JAMA : the journal of the American Medical Association 2004;292(20):2468-70.
2004: Van Bambeke Françoise; Carryn Stéphane; Seral Cristina; Chanteux Hugues; Tyteca Donatienne; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages.
Antimicrobial agents and chemotherapy 2004;48(8):2853-60.
2004: Michot Jean-Michel; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Active efflux of ciprofloxacin from J774 macrophages through an MRP-like transporter.
Antimicrobial agents and chemotherapy 2004;48(7):2673-82.
2004: Ben Abdelaziz Halim; Lemaire Sandrine; Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Inhibition of TNF-alpha production in THP-1 macrophages by glatiramer acetate does not alter their susceptibility to infection by Listeria monocytogenes and does not impair the efficacy of ampicillin or moxifloxacin against intracellular bacteria.
The Journal of antimicrobial chemotherapy 2004;54(1):288-9.
2004: Carryn Stéphane; Van de Velde Sébastien; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Impairment of growth of Listeria monocytogenes in THP-1 macrophages by granulocyte macrophage colony-stimulating factor: release of tumor necrosis factor-alpha and nitric oxide.
The Journal of infectious diseases 2004;189(11):2101-9.
2004: Nassogne Marie-Cécile; Lizarraga Chantal; N'Kuli Francisca; Van Bambeke Françoise; Van Binst Roger; Wallemacq Pierre; Tulkens Paul M; Mingeot-Leclercq Marie-Paule; Levade Thierry; Courtoy Pierre J
Cocaine induces a mixed lysosomal lipidosis in cultured fibroblasts, by inactivation of acid sphingomyelinase and inhibition of phospholipase A1.
Toxicology and applied pharmacology 2004;194(2):101-10.
2004: Van Bambeke Françoise; Van Laethem Yves; Courvalin Patrice; Tulkens Paul M
Glycopeptide antibiotics: from conventional molecules to new derivatives.
Drugs 2004;64(9):913-36.
2003: Chanteux Hugues; Mingeot-Leclercq Marie-Paule; Sonveaux Etienne; Van Bambeke Françoise; Tulkens Paul M
Intracellular accumulation and activity of ampicillin used as free drug and as its phthalimidomethyl or pivaloyloxymethyl ester (pivampicillin) against Listeria monocytogenes in J774 macrophages.
The Journal of antimicrobial chemotherapy 2003;52(4):610-5.
2003: Carryn Stéphane; Chanteux Hugues; Seral Cristina; Mingeot-Leclercq Marie-Paule; Van Bambeke Françoise; Tulkens Paul M
Intracellular pharmacodynamics of antibiotics.
Infectious disease clinics of North America 2003;17(3):615-34.
2003: Seral Cristina; Van Bambeke Françoise; Tulkens Paul M
Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages.
Antimicrobial agents and chemotherapy 2003;47(7):2283-92.
2003: Seral Cristina; Carryn Stéphane; Tulkens Paul M; Van Bambeke Françoise
Influence of P-glycoprotein and MRP efflux pump inhibitors on the intracellular activity of azithromycin and ciprofloxacin in macrophages infected by Listeria monocytogenes or Staphylococcus aureus.
The Journal of antimicrobial chemotherapy 2003;51(5):1167-73.
2003: Van Bambeke F; Glupczynski Y; Plésiat P; Pechère J C; Tulkens P M
Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy.
The Journal of antimicrobial chemotherapy 2003;51(5):1055-65.
2003: Van Bambeke F; Michot J-M; Tulkens P M
Antibiotic efflux pumps in eukaryotic cells: occurrence and impact on antibiotic cellular pharmacokinetics, pharmacodynamics and toxicodynamics.
The Journal of antimicrobial chemotherapy 2003;51(5):1067-77.
2003: Tyteca D; Schanck A; Dufrêne Y F; Deleu M; Courtoy P J; Tulkens P M; Mingeot-Leclercq M P
The macrolide antibiotic azithromycin interacts with lipids and affects membrane organization and fluidity: studies on Langmuir-Blodgett monolayers, liposomes and J774 macrophages.
The Journal of membrane biology 2003;192(3):203-15.
2003: Chanteux Hugues; Paternotte Isabelle; Mingeot-Leclercq Marie-Paule; Brasseur Robert; Sonveaux E; Tulkens Paul M
Cell handling, membrane-binding properties, and membrane-penetration modeling approaches of pivampicillin and phthalimidomethylampicillin, two basic esters of ampicillin, in comparison with chloroquine and azithromycin.
Pharmaceutical research 2003;20(4):624-31.
2003: Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Activity of beta-lactams (ampicillin, meropenem), gentamicin, azithromycin and moxifloxacin against intracellular Listeria monocytogenes in a 24 h THP-1 human macrophage model.
The Journal of antimicrobial chemotherapy 2003;51(4):1051-2.
2003: Baririan Nariné; Chanteux Hugues; Viaene Eric; Servais Hélène; Tulkens Paul M
Stability and compatibility study of cefepime in comparison with ceftazidime for potential administration by continuous infusion under conditions pertinent to ambulatory treatment of cystic fibrosis patients and to administration in intensive care units.
The Journal of antimicrobial chemotherapy 2003;51(3):651-8.
2003: Seral Cristina; Michot Jean-Michel; Chanteux Hugues; Mingeot-Leclercq Marie-Paule; Tulkens Paul M; Van Bambeke Françoise
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Antimicrobial agents and chemotherapy 2003;47(3):1047-51.
2002: Tyteca Donatienne; Van Der Smissen Patrick; Mettlen Marcel; Van Bambeke Françoise; Tulkens Paul M; Mingeot-Leclercq Marie Paule; Courtoy Pierre J
Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages.
Experimental cell research 2002;281(1):86-100.
2002: Viaene Eric; Chanteux Hugues; Servais Hélène; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Comparative stability studies of antipseudomonal beta-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units).
Antimicrobial agents and chemotherapy 2002;46(8):2327-32.
2002: Carryn Stéphane; Van Bambeke Françoise; Mingeot-Leclercq Marie-Paule; Tulkens Paul M
Comparative intracellular (THP-1 macrophage) and extracellular activities of beta-lactams, azithromycin, gentamicin, and fluoroquinolones against Listeria monocytogenes at clinically relevant concentrations.
Antimicrobial agents and chemotherapy 2002;46(7):2095-103.
2001: Servais H; Tulkens P M
Stability and compatibility of ceftazidime administered by continuous infusion to intensive care patients.
Antimicrobial agents and chemotherapy 2001;45(9):2643-7.
2001: Tyteca D; Van Der Smissen P; Van Bambeke F; Leys K; Tulkens P M; Courtoy P J; Mingeot-Leclercq M P
Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts.
European journal of cell biology 2001;80(7):466-78.
2001: Gholizadeh Y; Prevost M; Van Bambeke F; Casadewall B; Tulkens P M; Courvalin P
Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium.
Protein science : a publication of the Protein Society 2001;10(4):836-44.
2001: Paternotte I; Fan H J; Scrève P; Claesen M; Tulkens P M; Sonveaux E
Syntheses and hydrolysis of basic and dibasic ampicillin esters tailored for intracellular accumulation.
Bioorganic & medicinal chemistry 2001;9(2):493-502.
2001: Van Bambeke F; Tulkens P M
Macrolides: pharmacokinetics and pharmacodynamics.
International journal of antimicrobial agents 2001;18 Suppl 1():S17-23.
2000: Van Bambeke F; Balzi E; Tulkens P M
Antibiotic efflux pumps.
Biochemical pharmacology 2000;60(4):457-70.
2000: Prévost M; Van Belle D; Tulkens P M; Courvalin P; Van Bambeke F
Modeling of Enterococcus faecalis D-alanine:D-alanine ligase: structure-based study of the active site in the wild-type enzyme and in glycopeptide-dependent mutants.
Journal of molecular microbiology and biotechnology 2000;2(3):321-30.
2000: El Mouedden M; Laurent G; Mingeot-Leclercq M P; Tulkens P M
Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts.
Toxicological sciences : an official journal of the Society of Toxicology 2000;56(1):229-39.
2000: El Mouedden M; Laurent G; Mingeot-Leclercq M P; Taper H S; Cumps J; Tulkens P M
Apoptosis in renal proximal tubules of rats treated with low doses of aminoglycosides.
Antimicrobial agents and chemotherapy 2000;44(3):665-75.
2000: Van Bambeke F; Kerkhofs A; Schanck A; Remacle C; Sonveaux E; Tulkens P M; Mingeot-Leclercq M P
Biophysical studies and intracellular destabilization of pH-sensitive liposomes.
Lipids 2000;35(2):213-23.
1999: Ouadrhiri Y; Sibille Y; Tulkens P M
Modulation of intracellular growth of Listeria monocytogenes in human enterocyte Caco-2 cells by interferon-gamma and interleukin-6: role of nitric oxide and cooperation with antibiotics.
The Journal of infectious diseases 1999;180(4):1195-204.
1999: Buts J P; De Keyser N; Marandi S; Hermans D; Sokal E M; Chae Y H; Lambotte L; Chanteux H; Tulkens P M
Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats.
Gut 1999;45(1):89-96.
1999: Ouadrhiri Y; Scorneaux B; Sibille Y; Tulkens P M
Mechanism of the intracellular killing and modulation of antibiotic susceptibility of Listeria monocytogenes in THP-1 macrophages activated by gamma interferon.
Antimicrobial agents and chemotherapy 1999;43(5):1242-51.
1999: Mingeot-Leclercq M P; Tulkens P M
Aminoglycosides: nephrotoxicity.
Antimicrobial agents and chemotherapy 1999;43(5):1003-12.
1999: Montenez J P; Van Bambeke F; Piret J; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interactions of macrolide antibiotics (Erythromycin A, roxithromycin, erythromycylamine [Dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models.
Toxicology and applied pharmacology 1999;156(2):129-40.
1999: Mingeot-Leclercq M P; Glupczynski Y; Tulkens P M
Aminoglycosides: activity and resistance.
Antimicrobial agents and chemotherapy 1999;43(4):727-37.
1998: Van Bambeke F; Gerbaux C; Michot J M; d'Yvoire M B; Montenez J P; Tulkens P M
Lysosomal alterations induced in cultured rat fibroblasts by long-term exposure to low concentrations of azithromycin.
The Journal of antimicrobial chemotherapy 1998;42(6):761-7.
1998: Bouvier d'Yvoire M J; Dresco I A; Tulkens P M
Computer-aided prediction of macrolide antibiotic concentrations in human circulating polymorphonuclear leucocytes.
The Journal of antimicrobial chemotherapy 1998;41 Suppl B():63-8.
1996: Montenez J P; Van Bambeke F; Piret J; Schanck A; Brasseur R; Tulkens P M; Mingeot-Leclercq M P
Interaction of the macrolide azithromycin with phospholipids. II. Biophysical and computer-aided conformational studies.
European journal of pharmacology 1996;314(1-2):215-27.
1996: Van Bambeke F; Montenez J P; Piret J; Tulkens P M; Courtoy P J; Mingeot-Leclercq M P
Interaction of the macrolide azithromycin with phospholipids. I. Inhibition of lysosomal phospholipase A1 activity.
European journal of pharmacology 1996;314(1-2):203-14.
1996: Gerbaux C; Van Bambeke F; Montenez J P; Piret J; Morlighem G; Tulkens P M
Hyperactivity of cathepsin B and other lysosomal enzymes in fibroblasts exposed to azithromycin, a dicationic macrolide antibiotic with exceptional tissue accumulation.
FEBS letters 1996;394(3):307-10.
1996: Kishore B K; Fuming L u; Maldague P; Tulkens P M; Courtoy P J
Mechanism of the thesaurismosis and altered lysosomal dynamics induced by poly-D-glutamic acid in kidney proximal tubular cells.
Laboratory investigation; a journal of technical methods and pathology 1996;74(6):1025-37.
1996: Kishore B K; Maldague P; Tulkens P M; Courtoy P J
Poly-D-glutamic acid induces an acute lysosomal thesaurismosis of proximal tubules and a marked proliferation of interstitium in rat kidney.
Laboratory investigation; a journal of technical methods and pathology 1996;74(6):1013-23.
1996: Scorneaux B; Ouadrhiri Y; Anzalone G; Tulkens P M
Effect of recombinant human gamma interferon on intracellular activities of antibiotics against Listeria monocytogenes in the human macrophage cell line THP-1.
Antimicrobial agents and chemotherapy 1996;40(5):1225-30.
1996: van Bambeke F; Mingeot-Leclercq M P; Brasseur R; Tulkens P M; Schanck A
Aminoglycoside antibiotics prevent the formation of non-bilayer structures in negatively-charged membranes. Comparative studies using fusogenic (bis(beta-diethylaminoethylether)hexestrol) and aggregating (spermine) agents.
Chemistry and physics of lipids 1996;79(2):123-35.
1996: Tulkens P M
[Intracellular pharmacokinetics and pharmacodynamics of antibiotics]
Revue de pneumologie clinique 1996;52 Suppl 2():S51-5.
1995: Kotretsou S; Mingeot-Leclercq M P; Constantinou-Kokotou V; Brasseur R; Georgiadis M P; Tulkens P M
Synthesis and antimicrobial and toxicological studies of amino acid and peptide derivatives of kanamycin A and netilmicin.
Journal of medicinal chemistry 1995;38(23):4710-9.
1995: Van Bambeke F; Tulkens P M; Brasseur R; Mingeot-Leclercq M P
Aminoglycoside antibiotics induce aggregation but not fusion of negatively-charged liposomes.
European journal of pharmacology 1995;289(2):321-33.
1994: Montenez J P; Kishore B K; Maldague P; Tulkens P M
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
Toxicology letters 1994;73(3):201-8.
1994: Montenez J P; Delaissé J M; Tulkens P M; Kishore B K
Increased activities of cathepsin B and other lysosomal hydrolases in fibroblasts and bone tissue cultured in the presence of cysteine proteinases inhibitors.
Life sciences 1994;55(15):1199-208.
1994: Ibrahim S; Langhendries J P; Bernard A; Tulkens P M
Urinary phospholipids excretion in neonates treated with amikacin.
International journal of clinical pharmacology research 1994;14(5-6):149-56.
1994: Carlier M B; Garcia-Luque I; Montenez J P; Tulkens P M; Piret J
Accumulation, release and subcellular localization of azithromycin in phagocytic and non-phagocytic cells in culture.
International journal of tissue reactions 1994;16(5-6):211-20.
1993: Van Bambeke F; Mingeot-Leclercq M P; Schanck A; Brasseur R; Tulkens P M
Alterations in membrane permeability induced by aminoglycoside antibiotics: studies on liposomes and cultured cells.
European journal of pharmacology 1993;247(2):155-68.
1993: Langhendries J P; Battisti O; Bertrand J M; François A; Darimont J; Ibrahim S; Tulkens P M; Bernard A; Buchet J P; Scalais E
Once-a-day administration of amikacin in neonates: assessment of nephrotoxicity and ototoxicity.
Developmental pharmacology and therapeutics 1993;20(3-4):220-30.
1993: Kishore B K; Van Schepdael A; Laurent G; Lambricht P; Claes P J; Piret J; Tulkens P M; Maldague P
Co-oxydextran as a protectant against gentamicin-induced renal lysosomal phospholipidosis and focal tubular necrosis. Perspectives and limitations.
Contributions to nephrology 1993;101():213-9.
1992: Mingeot-Leclercq M P; Tulkens P M; Brasseur R
Accessibility of aminoglycosides, isolated and in interaction with phosphatidylinositol, to water. A conformational analysis using the concept of molecular hydrophobicity potential.
Biochemical pharmacology 1992;44(10):1967-75.
1992: Schanck A; Mingeot-Leclercq M P; Tulkens P M; Carrier D; Smith I C; Jarrell H C
Interactions of aminoglycoside antibiotics with phospholipids. A deuterium nuclear magnetic resonance study.
Chemistry and physics of lipids 1992;62(2):153-63.
1992: Kishore B K; Ibrahim S; Lambricht P; Laurent G; Maldague P; Tulkens P M
Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against gentamicin-induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats.
The Journal of pharmacology and experimental therapeutics 1992;262(1):424-32.
1992: Piret J; Kishore B K; Tulkens P M
Effect of substrate organization on the activity and on the mechanism of gentamicin-induced inhibition of rat liver lysosomal phospholipase A1.
Biochemical pharmacology 1992;43(4):895-8.
1991: Toubeau G; Nonclercq D; Zanen J; Lambricht P; Tulkens P M; Heuson-Stiennon J A; Laurent G
Distribution of epidermal growth factor in the kidneys of rats exposed to amikacin.
Kidney international 1991;40(4):691-9.
1991: Tulkens P M
Pharmacokinetic and toxicological evaluation of a once-daily regimen versus conventional schedules of netilmicin and amikacin.
The Journal of antimicrobial chemotherapy 1991;27 Suppl C():49-61.
1991: Meunier F; Van der Auwera P; Aoun M; Ibrahim S; Tulkens P M
Empirical antimicrobial therapy with a single daily dose of ceftriaxone plus amikacin in febrile granulocytopenic patients: a pilot study.
The Journal of antimicrobial chemotherapy 1991;27 Suppl C():129-39.
1991: Van der Auwera P; Meunier F; Ibrahim S; Kaufman L; Derde M P; Tulkens P M
Pharmacodynamic parameters and toxicity of netilmicin (6 milligrams/kilogram/day) given once daily or in three divided doses to cancer patients with urinary tract infection.
Antimicrobial agents and chemotherapy 1991;35(4):640-7.
1991: Van Schepdael A; Busson R; Vanderhaeghe H J; Claes P J; Verbist L; Mingeot-Leclercq M P; Brasseur R; Tulkens P M
New derivatives of kanamycin B obtained by combined modifications in positions 1 and 6". Synthesis, microbiological properties, and in vitro and computer-aided toxicological evaluation.
Journal of medicinal chemistry 1991;34(4):1483-92.
1991: Mingeot-Leclercq M P; Van Schepdael A; Brasseur R; Busson R; Vanderhaeghe H J; Claes P J; Tulkens P M
New derivatives of kanamycin B obtained by modifications and substitutions in position 6''. 2. In vitro and computer-aided toxicological evaluation with respect to interactions with phosphatidylinositol.
Journal of medicinal chemistry 1991;34(4):1476-82.
1991: Van Schepdael A; Delcourt J; Mulier M; Busson R; Verbist L; Vanderhaeghe H J; Mingeot-Leclercq M P; Tulkens P M; Claes P J
New derivatives of kanamycin B obtained by modifications and substitutions in position 6". 1. Synthesis and microbiological evaluation.
Journal of medicinal chemistry 1991;34(4):1468-75.
1991: Tulkens P M
Intracellular distribution and activity of antibiotics.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1991;10(2):100-6.
1990: Laurent G; Kishore B K; Tulkens P M
Aminoglycoside-induced renal phospholipidosis and nephrotoxicity.
Biochemical pharmacology 1990;40(11):2383-92.
1990: Kishore B K; Kállay Z; Lambricht P; Laurent G; Tulkens P M
Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro.
The Journal of pharmacology and experimental therapeutics 1990;255(2):867-74.
1990: Beauchamp D; Laurent G; Maldague P; Abid S; Kishore B K; Tulkens P M
Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by coadministration of poly-L-aspartic acid.
The Journal of pharmacology and experimental therapeutics 1990;255(2):858-66.
1990: Kishore B K; Lambricht P; Laurent G; Maldague P; Wagner R; Tulkens P M
Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-L-glutamic and poly-D-glutamic acids.
The Journal of pharmacology and experimental therapeutics 1990;255(2):875-85.
1990: Carlier M B; Scorneaux B; Zenebergh A; Desnottes J F; Tulkens P M
Cellular uptake, localization and activity of fluoroquinolones in uninfected and infected macrophages.
The Journal of antimicrobial chemotherapy 1990;26 Suppl B():27-39.
1990: Mingeot-Leclercq M P; Piret J; Tulkens P M; Brasseur R
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition induced by aminoglycoside antibiotics--II. Conformational analysis.
Biochemical pharmacology 1990;40(3):499-506.
1990: Mingeot-Leclercq M P; Piret J; Brasseur R; Tulkens P M
Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics--I. Biochemical analysis.
Biochemical pharmacology 1990;40(3):489-97.
1990: Kishore B K; Ibrahim S; Tulkens P M
Increased levels of protein- and lipid-bound sialic acids in the renal cortex of rats injected with low doses of gentamicin.
Toxicology letters 1990;51(1):59-65.
1990: Ibrahim S; Derde M P; Kaufman L; Clerckx-Braun F; Jacqmin P; Brulein V; Donnez J; Tulkens P M
Safety, pharmacokinetics and efficacy of once-a-day netilmicin and amikacin versus their conventional schedules in patients suffering from pelvic inflammatory disease.
Renal failure 1990;12(3):199-203.
1990: Tulkens P M
Efficacy and safety of aminoglycosides once-a-day: experimental and clinical data.
Scandinavian journal of infectious diseases. Supplementum 1990;74():249-57.
1990: Tulkens P M
Intracellular pharmacokinetics and localization of antibiotics as predictors of their efficacy against intraphagocytic infections.
Scandinavian journal of infectious diseases. Supplementum 1990;74():209-17.
1990: Nonclercq D; Toubeau G; Tulkens P; Heuson-Stiennon J A; Laurent G
Renal tissue injury and proliferative response after successive treatments with anticancer platinum derivatives and tobramycin.
Virchows Archiv. B, Cell pathology including molecular pathology 1990;59(3):143-58.
1990: Kishore B K; Lambricht P; Ibrahim S; Laurent G; Tulkens P M; Maldague P
Inhibition of aminoglycoside-induced nephrotoxicity in rats by polyanionic peptides.
Contributions to nephrology 1990;83():191-201.
1989: Nonclercq D; Toubeau G; Laurent G; Tulkens P M; Heuson-Stiennon J A
Tissue injury and repair in the rat kidney after exposure to cisplatin or carboplatin.
Experimental and molecular pathology 1989;51(2):123-40.
1989: Tulkens P M
Nephrotoxicity of aminoglycoside antibiotics.
Toxicology letters 1989;46(1-3):107-23.
1989: Mingeot-Leclercq M P; Schanck A; Ronveaux-Dupal M F; Deleers M; Brasseur R; Ruysschaert J M; Laurent G; Tulkens P M
Ultrastructural, physico-chemical and conformational study of the interactions of gentamicin and bis(beta-diethylaminoethylether) hexestrol with negatively-charged phospholipid layers.
Biochemical pharmacology 1989;38(5):729-41.
1989: Ibrahim S; Van der Auwera P; Meunier F; Tulkens P M
Effect of netilmicin and amikacin on urinary phospholipids excretion in humans.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():413-6.
1989: Kishore B K; Kállay Z; Tulkens P M
Clinico-biochemical aspects of guanidine compounds in uraemic toxicity.
International urology and nephrology 1989;21(2):223-32.
1989: Kishore B K; Tulkens P M
Comparative assessment of poly-L-aspartic and poly-L-glutamic acids as protectants against aminoglycoside-induced nephrotoxicity.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1989;13():409-12.
1988: Nonclercq D; Toubeau G; Laurent G; Maldague P; Tulkens P M; Heuson-Stiennon J A
Light and electron microscopic characterization of the proliferative response induced by tobramycin in rat kidney cortex.
Experimental and molecular pathology 1988;48(3):335-52.
1988: Bounkhala Z; Renard C; Baurain R; Marchand-Brynaert J; Ghosez L; Tulkens P M
Coupling products of amino acids to penicillin V and cephalothin: synthesis and susceptibility to carboxypeptidases and lysosomal enzymes.
Journal of medicinal chemistry 1988;31(5):976-83.
1988: Mingeot-Leclercq M P; Laurent G; Tulkens P M
Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases.
Biochemical pharmacology 1988;37(4):591-9.
1988: Laurent G; Toubeau G; Heuson-Stiennon J A; Tulkens P; Maldague P
Kidney tissue repair after nephrotoxic injury: biochemical and morphological characterization.
Critical reviews in toxicology 1988;19(2):147-83.
1988: Laurent G; Yernaux V; Nonclercq D; Toubeau G; Maldague P; Tulkens P M; Heuson-Stiennon J A
Tissue injury and proliferative response induced in rat kidney by cis-diamminedichloroplatinum (II).
Virchows Archiv. B, Cell pathology including molecular pathology 1988;55(3):129-45.
1987: Carlier M B; Zenebergh A; Tulkens P M
Cellular uptake and subcellular distribution of roxithromycin and erythromycin in phagocytic cells.
The Journal of antimicrobial chemotherapy 1987;20 Suppl B():47-56.
1987: Ibrahim S; Tulkens P
Patterns of phospholipids in renal cortex and urine of gentamicin-treated rats.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 1987;6(2 Suppl):330-1.
1987: Abid S; Carlier M B; Laurent G; Tulkens P; Maldague P
Comparative regenerative response of rat kidney cortex after treatment with therapeutic doses of aminoglycosides.
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy 1987;6(2 Suppl):329.
1987: Renard C; Vanderhaeghe H J; Claes P J; Zenebergh A; Tulkens P M
Influence of conversion of penicillin G into a basic derivative on its accumulation and subcellular localization in cultured macrophages.
Antimicrobial agents and chemotherapy 1987;31(3):410-6.
1986: Giurgea-Marion L; Toubeau G; Laurent G; Heuson-Stiennon J A; Tulkens P M
Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses.
Toxicology and applied pharmacology 1986;86(2):271-85.
1986: Renard C; Michel A; Tulkens P M
Hydrolysis of Pro-Ala dipeptides by lysosomal hydrolases. Models for the study of lysosomotropic amino acid prodrugs of penicillins.
Journal of medicinal chemistry 1986;29(7):1291-3.
1986: Bernard A; Viau C; Ouled A; Tulkens P; Lauwerys R
Effects of gentamicin on the renal uptake of endogenous and exogenous protein in conscious rats.
Toxicology and applied pharmacology 1986;84(3):431-8.
1986: Tulkens P M
Experimental studies on nephrotoxicity of aminoglycosides at low doses. Mechanisms and perspectives.
The American journal of medicine 1986;80(6B):105-14.
1986: Toubeau G; Laurent G; Carlier M B; Abid S; Maldague P; Heuson-Stiennon J A; Tulkens P M
Tissue repair in rat kidney cortex after short treatment with aminoglycosides at low doses. A comparative biochemical and morphometric study.
Laboratory investigation; a journal of technical methods and pathology 1986;54(4):385-93.
1986: Rollman B; Van Der Auwera P; Tulkens P M
Dibekacin assay in serum by automated fluorescence polarization immunoassay (Abbott Tdx): Comparison with high-performance liquid chromatography, substrate-labelled fluorescent immunoassay and radioimmunoassay.
Journal of pharmaceutical and biomedical analysis 1986;4(1):53-61.
1986: Beauchamp D; Laurent G; Maldague P; Tulkens P M
Reduction of gentamicin nephrotoxicity by the concomitant administration of poly-l-aspartic acid and poly-l-asparagine in rats.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1986;9():306-9.
1986: Toubeau G; Maldague P; Laurent G; Vaamonde C A; Tulkens P M; Heuson-Stiennon J A
Morphological alterations in distal and collecting tubules of the rat renal cortex after aminoglycoside administration at low doses.
Virchows Archiv. B, Cell pathology including molecular pathology 1986;51(6):475-85.
1985: Brasseur R; Carlier M B; Laurent G; Claes P J; Vanderhaeghe H J; Tulkens P M; Ruysschaert J M
Interaction of streptomycin and streptomycylamine derivatives with negatively charged lipid layers. Correlation between binding, conformation of complexes and inhibition of lysosomal phospholipase activities.
Biochemical pharmacology 1985;34(7):1035-47.
1984: Giuliano R A; Paulus G J; Verpooten G A; Pattyn V M; Pollet D E; Nouwen E J; Laurent G; Carlier M B; Maldague P; Tulkens P M
Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats.
Kidney international 1984;26(6):838-47.
1984: Porter G A; Laurent G; Maldague P; Tulkens P
Gentamicin-induced stimulation of DNA synthesis in rat kidney. Comparison between in vivo and in vitro models.
Toxicology letters 1984;23(2):205-13.
1984: De Broe M E; Paulus G J; Verpooten G A; Roels F; Buyssens N; Wedeen R; Van Hoof F; Tulkens P M
Early effects of gentamicin, tobramycin, and amikacin on the human kidney.
Kidney international 1984;25(4):643-52.
1984: Brasseur R; Laurent G; Ruysschaert J M; Tulkens P
Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochemical and conformational studies.
Biochemical pharmacology 1984;33(4):629-37.
1984: Laurent G; Toubeau G; Maldague P; Carlier M B; Heuson-Stiennon J A; Tulkens P
Tubular regeneration in rat kidney cortex during treatment with gentamicin at a low dose.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1984;7():459-63.
1984: Maldague P; Laurent G; Carlier M B; Tulkens P
A 2'guanidyl derivative of gentamicin (S86451) with reduced nephrotoxicity studies at low and medium dose levels in the rat.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1984;7():455-8.
1984: Carlier M B; Laurent G; Tulkens P
In vitro inhibition of lysosomal phospholipases by aminoglycoside antibiotics: a comparative study.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1984;7():282-5.
1984: Tulkens P M
Aminoglycoside nephrotoxicity: recent insights and perspectives.
Contributions to nephrology 1984;42():168-81.
1983: Laurent G; Maldague P; Carlier M B; Tulkens P M
Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats.
Antimicrobial agents and chemotherapy 1983;24(4):586-93.
1983: Viau C; Bernard A; Lauwerys R R; Tulkens P; Laurent G; Maldague P
Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.
Toxicology 1983;27(1):15-25.
1983: Carlier M B; Laurent G; Claes P J; Vanderhaeghe H J; Tulkens P M
Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.
Antimicrobial agents and chemotherapy 1983;23(3):440-9.
1983: Fillastre J P; Hemet J; Tulkens P; Morin J P; Viotte G; Olier B; Godin M
Comparative nephrotoxicity of four aminoglycosides: biochemical and ultrastructural modifications of lysosomes.
Advances in nephrology from the Necker Hospital 1983;12():253-75.
1982: Laurent G; Carlier M B; Rollman B; Van Hoof F; Tulkens P
Mechanism of aminoglycoside-induced lysosomal phospholipidosis: in vitro and in vivo studies with gentamicin and amikacin.
Biochemical pharmacology 1982;31(23):3861-70.
1982: Carlier M B; Paulus G; Maldague P; Giurgea L; Wilmotte E; de Broe M E; Tulkens P
Early toxic events in kidney of rat and man following administration of gentamicin at low doses.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1982;5():287-90.
1981: De Broe M E; Paulus G; Verpooten G A; Roels F; Van Hoof F; Tulkens P
Prospective comparative study of the nephrotoxicity of aminoglycosides in human (abstract).
The Journal of antimicrobial chemotherapy 1981;8 Suppl A():111-3.
1981: Sauvage P; Lopez-Saura P; Leroy-Houyet M A; Tulkens P; Trouet A
Analytical characterization and purification of plasma membrane from cultured hepatoma cells (HTC cells).
Biochimica et biophysica acta 1981;644(1):41-52.
1980: Morin J P; Viotte G; Vandewalle A; Van Hoof F; Tulkens P; Fillastre J P
Gentamicin-induced nephrotoxicity: a cell biology approach.
Kidney international 1980;18(5):583-90.
1980: Tulkens P; Van Hoof F
Comparative toxicity of aminoglycoside antibiotics towards the lysosomes in a cell culture model.
Toxicology 1980;17(2):195-9.
1979: Schneider Y J; Tulkens P; de Duve C; Trouet A
Fate of plasma membrane during endocytosis. II. Evidence for recycling (shuttle) of plasma membrane constituents.
The Journal of cell biology 1979;82(2):466-74.
1979: Schneider Y J; Tulkens P; de Duve C; Trouet A
Fate of plasma membrane during endocytosis. I. Uptake and processing of anti-plasma membrane and control immunoglobulins by cultured fibroblasts.
The Journal of cell biology 1979;82(2):449-65.
1979: Blanchard J C; Schneider Y J; Tulkens P; Trouet A
Cellular uptake and subcellular distribution of two non-steroidal anti-inflammatory drugs: indomethacin and ketoprofen.
Archives internationales de pharmacodynamie et de thérapie 1979;240(1):4-16.
1979: Aubert-Tulkens G; Van Hoof F; Tulkens P
Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts. Quantitative ultrastructural and biochemical study.
Laboratory investigation; a journal of technical methods and pathology 1979;40(4):481-91.
1979: Libert J; Ketelbant-Balasse P E; Van Hoof F; Aubert-Tulkens G; Tulkens P
Cellular toxicity of gentamicin.
American journal of ophthalmology 1979;87(3):405-11.
1979: Tulkens P; Schneider Y J; Trouet A
Recycling (shuttle) of cell surface membrane during endocytosis.
Advances in experimental medicine and biology 1979;114():413-4.
1979: Tulkens P; Trouet A
The concept of drug-carriers in the treatment of parasitic diseases.
Advances in experimental medicine and biology 1979;114():411-2.
1978: Lopez-Saura P; Trouet A; Tulkens P
Analytical fractionation of cultured hepatoma cells (HTC cells).
Biochimica et biophysica acta 1978;543(4):430-49.
1978: Bulychev A; Trouet A; Tulkens P
Uptake and intracellular distribution of neutral red in cultured fibroblasts.
Experimental cell research 1978;115(2):343-55.
1978: Noel G; Peterson C; Trouet A; Tulkens P
Uptake and subcellular localization of daunorubicin and adriamycin in cultured fibroblasts.
European journal of cancer 1978;14(4):363-8.
1978: Tulkens P; Trouet A
The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts.
Biochemical pharmacology 1978;27(4):415-24.
1977: Couvreur P; Tulkens P; Roland M; Trouet A; Speiser P
Nanocapsules: a new type of lysosomotropic carrier.
FEBS letters 1977;84(2):323-6.
1977: Schneider Y J; Tulkens P; Trouet A
Recycling of fibroblast plasma-membrane antigens internalized during endocytosis [proceedings]
Biochemical Society transactions 1977;5(4):1164-7.
1977: Pierart-Gallois M; Trouet A; Tulkens P
Production of rabbit antibodies against active rat cathepsin B.
Acta biologica et medica Germanica 1977;36(11-12):1887-91.
1977: Tulkens P; Schneider Y J; Trouet A
Flow and shuttle of plasma membrane during endocytosis.
Acta biologica et medica Germanica 1977;36(11-12):1681-90.
1977: Tulkens P; Schneider Y J; Trouet A
The fate of the plasma membrane during endocytosis.
Biochemical Society transactions 1977;5(6):1809-15.
1976: Bulychev A; Trouet A; Tulkens P
Accumulation and localization of neutral red in cultured fibroblasts [proceedings].
Archives internationales de physiologie et de biochimie 1976;84(5):1055-6.
1976: Zenebergh A; Loni M C; Tulkens P
Biochemical characterization of lysosomes and plasma membrane of cultured leukaemic L1210 cells.
Archives internationales de physiologie et de biochimie 1976;84(3):684-6.
1976: Schneider Y J; Tulkens P; Trouet A
Uptake and localization of cathepsin D and of antibodies, directed against lysosomes or cathepsin D in cultured fibroblasts.
Archives internationales de physiologie et de biochimie 1976;84(3):655-7.
1976: Liesse M; Lhoest G; Trouet A; Tulkens P
Uptake and intracellular localization of morphine in lysosomes and cell sap of cultured fibroblasts.
Archives internationales de physiologie et de biochimie 1976;84(3):638-9.
1975: Schneider Y J; Trouet A; Tulkens P
Intracellular fate of plasma membrane antigens during endocytosis.
Archives internationales de physiologie et de biochimie 1975;83(5):997-8.
1975: Sauvage P; Trouet A; Tulkens P
Purification and antigenic characterization of plasma membrane from hepatoma cells in culture (HTC cells).
Archives internationales de physiologie et de biochimie 1975;83(5):995-6.
1975: Tulkens P; Van Hoof F; Trouet A
Lysosome overloading and dysfunction induced by streptomycin in cultured fibroblasts.
Archives internationales de physiologie et de biochimie 1975;83(5):1004-6.
1974: Tulkens P; Trouet A
Uptake and intracellular localization of kanamycin and gentamycin in the lysosomes of cultured fibroblasts.
Archives internationales de physiologie et de biochimie 1974;82(5):1018-9.
1974: Tulkens P; Beaufay H; Trouet A
Analytical fractionation of homogenates from cultured rat embryo fibroblasts.
The Journal of cell biology 1974;63(2 Pt 1):383-401.
1974: Schneider Y J; Trouet A; Tulkens P
Proceedings: Uptake and intracellular fate of anti-plasma membrane antibodies in cultured fibroblasts.
Hoppe-Seyler's Zeitschrift für physiologische Chemie 1974;355(10):1252.
1974: de Duve C; de Barsy T; Poole B; Trouet A; Tulkens P; Van Hoof F
Commentary. Lysosomotropic agents.
Biochemical pharmacology 1974;23(18):2495-531.
1972: Lopez-Saura P; Tulkens P; Trouet A
Characterization of subcellular constituents of hepatoma cultured cells (HTC cells).
Archives internationales de physiologie et de biochimie 1972;80(5):977-8.
1970: Tulkens P; Trouet A; Van Hoof F
Immunological inhibition of lysosome function.
Nature 1970;228(5278):1282-5.
1968: Tulkens P; Wattiaux R
[A note concerning fractional centrifugation of rat liver]
Experientia 1968;24(3):222-3.
1964: WATTIAUX R; WATTIAUX-DECONINCK S; RUTGEERTS M J; TULKENS P
INFLUENCE OF THE INJECTION OF A SUCROSE SOLUTION ON THE PROPERTIES OF RAT-LIVER LYSOSOMES.
Nature 1964;203():757-8.

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