Richard Titball

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Yang Zheng Rong; Lertmemongkolchai Ganjana; Tan Gladys; Felgner Philip L; Titball Richard
A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery.
Felgner Philip L; Kayala Matthew A; Vigil Adam; Burk Chad; Nakajima-Sasaki Rie; Pablo Jozelyn; Molina Douglas M; Hirst Siddiqua; Chew Janet S W; Wang Dongling; Tan Gladys; Duffield Melanie; Yang Ron; Neel Julien; Chantratita Narisara; Bancroft Greg; Lertmemongkolchai Ganjana; Davies D Huw; Baldi Pierre; Peacock Sharon; Titball Richard W
A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens.
Thwaite Joanne E; Humphrey Suzanne; Fox Marc A; Savage Victoria L; Laws Thomas R; Ulaeto David O; Titball Richard W; Atkins Helen S
The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains.

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All Publications

2009: Yang Zheng Rong; Lertmemongkolchai Ganjana; Tan Gladys; Felgner Philip L; Titball Richard
A genetic programming approach for Burkholderia pseudomallei diagnostic pattern discovery.
Bioinformatics (Oxford, England) 2009;25(17):2256-62.
2009: Felgner Philip L; Kayala Matthew A; Vigil Adam; Burk Chad; Nakajima-Sasaki Rie; Pablo Jozelyn; Molina Douglas M; Hirst Siddiqua; Chew Janet S W; Wang Dongling; Tan Gladys; Duffield Melanie; Yang Ron; Neel Julien; Chantratita Narisara; Bancroft Greg; Lertmemongkolchai Ganjana; Davies D Huw; Baldi Pierre; Peacock Sharon; Titball Richard W
A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13499-504.
2009: Thwaite Joanne E; Humphrey Suzanne; Fox Marc A; Savage Victoria L; Laws Thomas R; Ulaeto David O; Titball Richard W; Atkins Helen S
The cationic peptide magainin II is antimicrobial for Burkholderia cepacia-complex strains.
Journal of medical microbiology 2009;58(Pt 7):923-9.
2009: Sarkar-Tyson Mitali; Smither Sophie J; Harding S V; Atkins Timothy P; Titball Richard W
Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders.
Vaccine 2009;27(33):4447-51.
2009: Champion Olivia L; Cooper Ian A M; James Sarah L; Ford Donna; Karlyshev Andrey; Wren Brendan W; Duffield Melanie; Oyston Petra C F; Titball Richard W
Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis.
Microbiology (Reading, England) 2009;155(Pt 5):1516-22.
2009: Thomas Richard J; Webber Daniel; Collinge Aaron; Stagg Anthony J; Bailey Stephen C; Nunez Alejandro; Gates Amanda; Jayasekera Pramukh N; Taylor Rosa R; Eley Steve; Titball Richard W
Different pathologies but equal levels of responsiveness to the recombinant F1 and V antigen vaccine and ciprofloxacin in a murine model of plague caused by small- and large-particle aerosols.
Infection and immunity 2009;77(4):1315-23.
2009: Van Immerseel Filip; Rood Julian I; Moore Robert J; Titball Richard W
Rethinking our understanding of the pathogenesis of necrotic enteritis in chickens.
Trends in microbiology 2009;17(1):32-6.
2009: Tippayawat Patcharaporn; Saenwongsa Wipawee; Mahawantung Jirawan; Suwannasaen Duangchan; Chetchotisakd Ploenchan; Limmathurotsakul Direk; Peacock Sharon J; Felgner Philip L; Atkins Helen S; Titball Richard W; Bancroft Gregory J; Lertmemongkolchai Ganjana
Phenotypic and Functional Characterization of Human Memory T Cell Responses to Burkholderia pseudomallei.
PLoS neglected tropical diseases 2009;3(4):e407.
2008: Thompson Denis B; Crandall Kerianne; Harding Sarah V; Smither Sophie J; Kitto G Barrie; Titball Richard W; Brown Katherine A
In silico analysis of potential diagnostic targets from Burkholderia pseudomallei.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102 Suppl 1():S61-5.
2008: Gnanam Annie J; Hall Bradley; Shen Xiaofan; Piasecki Shawn; Vernados Anna; Galyov Edouard E; Smither Sophie J; Kitto G Barrie; Titball Richard W; Ellington Andrew D; Brown Katherine A
Development of aptamers specific for potential diagnostic targets in Burkholderia pseudomallei.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102 Suppl 1():S55-7.
2008: Titball Richard W; Russell Paul; Cuccui Jon; Easton Anna; Haque Ashraful; Atkins Tim; Sarkar-Tyson Mitali; Harley Vicki; Wren Brendan; Bancroft Gregory J
Burkholderia pseudomallei: animal models of infection.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2008;102 Suppl 1():S111-6.
2008: Hoang Tran H; Hong Huynh A; Clark Graeme C; Titball Richard W; Cutting Simon M
Recombinant Bacillus subtilis expressing the Clostridium perfringens alpha toxoid is a candidate orally delivered vaccine against necrotic enteritis.
Infection and immunity 2008;76(11):5257-65.
2008: Thomas Richard J; Webber Daniel; Sellors William; Collinge Aaron; Frost Andrew; Stagg Anthony J; Bailey Stephen C; Jayasekera Pramukh N; Taylor Rosa R; Eley Steve; Titball Richard W
Characterization and deposition of respirable large- and small-particle bioaerosols.
Applied and environmental microbiology 2008;74(20):6437-43.
2008: Halling-Brown Mark; Sansom Clare E; Davies Matthew; Titball Richard W; Moss David S
Are bacterial vaccine antigens T-cell epitope depleted?
Trends in immunology 2008;29(8):374-9.
2008: Titball Richard W
Vaccines against intracellular bacterial pathogens.
Drug discovery today 2008;13(13-14):596-600.
2008: Lukaszewski R A; Yates A M; Jackson M C; Swingler K; Scherer J M; Simpson A J; Sadler P; McQuillan P; Titball R W; Brooks T J G; Pearce M J
Presymptomatic prediction of sepsis in intensive care unit patients.
Clinical and vaccine immunology : CVI 2008;15(7):1089-94.
2008: Eyles J E; Hartley M G; Laws T R; Oyston P C F; Griffin K F; Titball R W
Protection afforded against aerosol challenge by systemic immunisation with inactivated Francisella tularensis live vaccine strain (LVS).
Microbial pathogenesis 2008;44(2):164-8.
2008: Stabler Richard A; Dawson Lisa F; Oyston Petra C F; Titball Richard W; Wade Jim; Hinds Jason; Witney Adam A; Wren Brendan W
Development and application of the active surveillance of pathogens microarray to monitor bacterial gene flux.
BMC microbiology 2008;8():177.
2007: Tanabe Mikio; Mirza Osman; Bertrand Thomas; Atkins Helen S; Titball Richard W; Iwata So; Brown Katherine A; Byrne Bernadette
Structures of OppA and PstS from Yersinia pestis indicate variability of interactions with transmembrane domains.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1185-93.
2007: Legutki Joseph B; Nelson Michelle; Titball Richard; Galloway Darrell R; Mateczun Alfred; Baillie Leslie W
Analysis of peptide mimotopes of Burkholderia pseudomallei exopolysaccharide.
Vaccine 2007;25(45):7796-805.
2007: Milne Timothy S; Michell Stephen L; Diaper Helen; Wikström Per; Svensson Kerstin; Oyston Petra C F; Titball Richard W
A 55 kDa hypothetical membrane protein is an iron-regulated virulence factor of Francisella tularensis subsp. novicida U112.
Journal of medical microbiology 2007;56(Pt 10):1268-76.
2007: Eyles Jim E; Butcher Wendy A; Titball Richard W; Hill Jim
Concomitant administration of Yersinia pestis specific monoclonal antibodies with plague vaccine has a detrimental effect on vaccine mediated immunity.
Vaccine 2007;25(42):7301-6.
2007: Cowan Graeme J M; Atkins Helen S; Johnson Linda K; Titball Richard W; Mitchell Tim J
Immunisation with anthrolysin O or a genetic toxoid protects against challenge with the toxin but not against Bacillus anthracis.
Vaccine 2007;25(41):7197-205.
2007: Neeson Brendan N; Clark Graeme C; Atkins Helen S; Lingard Bryan; Titball Richard W
Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C.
Microbial pathogenesis 2007;43(4):161-5.
2007: Sarkar-Tyson M; Thwaite J E; Harding S V; Smither S J; Oyston P C F; Atkins T P; Titball R W
Polysaccharides and virulence of Burkholderia pseudomallei.
Journal of medical microbiology 2007;56(Pt 8):1005-10.
2007: Harland David N; Chu Karen; Haque Ashraful; Nelson Michelle; Walker Nicola J; Sarkar-Tyson Mitali; Atkins Timothy P; Moore Benjamin; Brown Katherine A; Bancroft Gregory; Titball Richard W; Atkins Helen S
Identification of a LolC homologue in Burkholderia pseudomallei, a novel protective antigen for melioidosis.
Infection and immunity 2007;75(8):4173-80.
2007: Sundaresh Suman; Randall Arlo; Unal Berkay; Petersen Jeannine M; Belisle John T; Hartley M Gill; Duffield Melanie; Titball Richard W; Davies D Huw; Felgner Philip L; Baldi Pierre
From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis.
Bioinformatics (Oxford, England) 2007;23(13):i508-18.
2007: Eyles Jim E; Unal Berkay; Hartley Margaret Gill; Newstead Sarah L; Flick-Smith Helen; Prior Joann L; Oyston Petra C F; Randall Arlo; Mu Yunxiang; Hirst Siddiqua; Molina Douglas M; Davies D Huw; Milne Tim; Griffin Kate F; Baldi Pierre; Titball Rick W; Felgner Philip L
Immunodominant Francisella tularensis antigens identified using proteome microarray. Crown Copyright 2007 Dstl.
Proteomics 2007;7(13):2172-83.
2007: Titball Richard W; Petrosino Joseph F
Francisella tularensis genomics and proteomics.
Annals of the New York Academy of Sciences 2007;1105():98-121.
2007: Titball Richard W; Sjostedt Anders; Pavelka Martin S; Nano Francis E
Biosafety and selectable markers.
Annals of the New York Academy of Sciences 2007;1105():405-17.
2007: Garbom Sara; Olofsson Martina; Björnfot Ann-Catrin; Srivastava Manoj Kumar; Robinson Victoria L; Oyston Petra C F; Titball Richard W; Wolf-Watz Hans
Phenotypic characterization of a virulence-associated protein, VagH, of Yersinia pseudotuberculosis reveals a tight link between VagH and the type III secretion system.
Microbiology (Reading, England) 2007;153(Pt 5):1464-73.
2007: Griffin Kate F; Oyston Petra C F; Titball Richard W
Francisella tularensis vaccines.
FEMS immunology and medical microbiology 2007;49(3):315-23.
2007: Wilkinson L J; Duffield M L; Titball R W; Lindsay C D
Down-regulation of gene transcripts associated with ricin tolerance in human RPMI 2650 cells.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(3):509-20.
2007: Stokes Margaret G M; Titball Richard W; Neeson Brendan N; Galen James E; Walker Nicola J; Stagg Anthony J; Jenner Dominic C; Thwaite Joanne E; Nataro James P; Baillie Leslie W J; Atkins Helen S
Oral administration of a Salmonella enterica-based vaccine expressing Bacillus anthracis protective antigen confers protection against aerosolized B. anthracis.
Infection and immunity 2007;75(4):1827-34.
2007: Titball Richard W; Oyston Petra C F
A plague upon fibrin.
Nature medicine 2007;13(3):253-4.
2007: Harding Sarah V; Sarkar-Tyson Mitali; Smither Sophie J; Atkins Timothy P; Oyston Petra C F; Brown Katherine A; Liu Yichun; Wait Robin; Titball Richard W
The identification of surface proteins of Burkholderia pseudomallei.
Vaccine 2007;25(14):2664-72.
2007: Quarry J E; Isherwood K E; Michell S L; Diaper H; Titball R W; Oyston P C F
A Francisella tularensis subspecies novicida purF mutant, but not a purA mutant, induces protective immunity to tularemia in mice.
Vaccine 2007;25(11):2011-8.
2007: Cuccui J; Easton A; Chu K K; Bancroft G J; Oyston P C F; Titball R W; Wren B W
Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis.
Infection and immunity 2007;75(3):1186-95.
2007: Williamson E D; Stagg A J; Eley S M; Taylor R; Green M; Jones S M; Titball R W
Kinetics of the immune response to the (F1+V) vaccine in models of bubonic and pneumonic plague.
Vaccine 2007;25(6):1142-8.
2007: Thomas Rebecca M; Titball Richard W; Oyston Petra C F; Griffin Kate; Waters Emma; Hitchen Paul G; Michell Stephen L; Grice I Darren; Wilson Jennifer C; Prior Joann L
The immunologically distinct O antigens from Francisella tularensis subspecies tularensis and Francisella novicida are both virulence determinants and protective antigens.
Infection and immunity 2007;75(1):371-8.
2007: Duc Le H; Hong Huynh A; Atkins Helen S; Flick-Smith Helen C; Durrani Zarmina; Rijpkema Sjoerd; Titball Richard W; Cutting Simon M
Immunization against anthrax using Bacillus subtilis spores expressing the anthrax protective antigen.
Vaccine 2007;25(2):346-55.
2007: Smither Sophie J; Hill Jim; van Baar Ben L M; Hulst Albert G; de Jong Ad L; Titball Richard W
Identification of outer membrane proteins of Yersinia pestis through biotinylation.
Journal of microbiological methods 2007;68(1):26-31.
2007: Wood Robert J; Maynard-Smith Michael D; Robinson Victoria L; Oyston Petra C F; Titball Rick W; Roach Peter L
Kinetic analysis of Yersinia pestis DNA adenine methyltransferase activity using a hemimethylated molecular break light oligonucleotide.
PloS one 2007;2(8):e801.
2007: Chaudhuri Roy R; Ren Chuan-Peng; Desmond Leah; Vincent Gemma A; Silman Nigel J; Brehm John K; Elmore Michael J; Hudson Michael J; Forsman Mats; Isherwood Karen E; Gurycová Darina; Minton Nigel P; Titball Richard W; Pallen Mark J; Vipond Richard
Genome sequencing shows that European isolates of Francisella tularensis subspecies tularensis are almost identical to US laboratory strain Schu S4.
PloS one 2007;2(4):e352.
2007: Harland David N; Dassa Elie; Titball Richard W; Brown Katherine A; Atkins Helen S
ATP-binding cassette systems in Burkholderia pseudomallei and Burkholderia mallei.
BMC genomics 2007;8():83.
2006: Rodrigues Fiona; Sarkar-Tyson Mitali; Harding Sarah V; Sim Siew Hoon; Chua Hui Hoon; Lin Chi Ho; Han Xu; Karuturi R Krishna M; Sung Ken; Yu Kun; Chen Wei; Atkins Timothy P; Titball Richard W; Tan Patrick
Global map of growth-regulated gene expression in Burkholderia pseudomallei, the causative agent of melioidosis.
Journal of bacteriology 2006;188(23):8178-88.
2006: Haque Ashraful; Chu Karen; Easton Anna; Stevens Mark P; Galyov Edouard E; Atkins Tim; Titball Rick; Bancroft Gregory J
A live experimental vaccine against Burkholderia pseudomallei elicits CD4+ T cell-mediated immunity, priming T cells specific for 2 type III secretion system proteins.
The Journal of infectious diseases 2006;194(9):1241-8.
2006: Myers Garry S A; Rasko David A; Cheung Jackie K; Ravel Jacques; Seshadri Rekha; DeBoy Robert T; Ren Qinghu; Varga John; Awad Milena M; Brinkac Lauren M; Daugherty Sean C; Haft Daniel H; Dodson Robert J; Madupu Ramana; Nelson William C; Rosovitz M J; Sullivan Steven A; Khouri Hoda; Dimitrov George I; Watkins Kisha L; Mulligan Stephanie; Benton Jonathan; Radune Diana; Fisher Derek J; Atkins Helen S; Hiscox Tom; Jost B Helen; Billington Stephen J; Songer J Glenn; McClane Bruce A; Titball Richard W; Rood Julian I; Melville Stephen B; Paulsen Ian T
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens.
Genome research 2006;16(8):1031-40.
2006: Thwaite Joanne E; Hibbs Stephen; Titball Richard W; Atkins Timothy P
Proteolytic degradation of human antimicrobial peptide LL-37 by Bacillus anthracis may contribute to virulence.
Antimicrobial agents and chemotherapy 2006;50(7):2316-22.
2006: Atkins Helen S; Dassa Elie; Walker Nicola J; Griffin Kate F; Harland David N; Taylor Rosa R; Duffield Melanie L; Titball Richard W
The identification and evaluation of ATP binding cassette systems in the intracellular bacterium Francisella tularensis.
Research in microbiology 2006;157(6):593-604.
2006: Tanabe Mikio; Atkins Helen S; Harland David N; Elvin Stephen J; Stagg Anthony J; Mirza Osman; Titball Richard W; Byrne Bernadette; Brown Katherine A
The ABC transporter protein OppA provides protection against experimental Yersinia pestis infection.
Infection and immunity 2006;74(6):3687-91.
2006: Laws Thomas R; Atkins Helen S; Atkins Timothy P; Titball Richard W
The pathogen Pseudomonas aeruginosa negatively affects the attraction response of the nematode Caenorhabditis elegans to bacteria.
Microbial pathogenesis 2006;40(6):293-7.
2006: Hill Jim; Eyles Jim E; Elvin Stephen J; Healey Gareth D; Lukaszewski Roman A; Titball Richard W
Administration of antibody to the lung protects mice against pneumonic plague.
Infection and immunity 2006;74(5):3068-70.
2006: Bryant A E; Bayer C R; Aldape M J; Wallace R J; Titball R W; Stevens D L
Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis.
Journal of medical microbiology 2006;55(Pt 5):495-504.
2006: Atkins Helen S; Morton Margaret; Griffin Kate F; Stokes Margaret G M; Nataro James P; Titball Richard W
Recombinant Salmonella vaccines for biodefence.
Vaccine 2006;24(15):2710-7.
2006: Forslund Anna-Lena; Kuoppa Kerstin; Svensson Kerstin; Salomonsson Emelie; Johansson Anders; Byström Mona; Oyston Petra C F; Michell Stephen L; Titball Richard W; Noppa Laila; Frithz-Lindsten Elisabet; Forsman Mats; Forsberg Ake
Direct repeat-mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis.
Molecular microbiology 2006;59(6):1818-30.
2006: Haque Ashraful; Easton Anna; Smith Debbie; O'Garra Anne; Van Rooijen Nico; Lertmemongkolchai Ganjana; Titball Richard W; Bancroft Gregory J
Role of T cells in innate and adaptive immunity against murine Burkholderia pseudomallei infection.
The Journal of infectious diseases 2006;193(3):370-9.
2006: Hartley Gill; Taylor Rosa; Prior Jo; Newstead Sarah; Hitchen Paul G; Morris Howard R; Dell Anne; Titball Richard W
Grey variants of the live vaccine strain of Francisella tularensis lack lipopolysaccharide O-antigen, show reduced ability to survive in macrophages and do not induce protective immunity in mice.
Vaccine 2006;24(7):989-96.
2005: Harrison Ben; Raju Deepa; Garmory Helen S; Brett Moira M; Titball Richard W; Sarker Mahfuzur R
Molecular characterization of Clostridium perfringens isolates from humans with sporadic diarrhea: evidence for transcriptional regulation of the beta2-toxin-encoding gene.
Applied and environmental microbiology 2005;71(12):8362-70.
2005: Robinson Victoria L; Oyston Petra C F; Titball Richard W
A dam mutant of Yersinia pestis is attenuated and induces protection against plague.
FEMS microbiology letters 2005;252(2):251-6.
2005: Titball Richard W
Gas gangrene: an open and closed case.
Microbiology (Reading, England) 2005;151(Pt 9):2821-8.
2005: Laws Thomas R; Smith Simon A; Smith Martin P; Harding Sarah V; Atkins Timothy P; Titball Richard W
The nematode Panagrellus redivivus is susceptible to killing by human pathogens at 37 degrees C.
FEMS microbiology letters 2005;250(1):77-83.
2005: Flores-Díaz Marietta; Alape-Girón Alberto; Clark Graeme; Catimel Bruno; Hirabayashi Yoshio; Nice Ed; Gutiérrez José-María; Titball Richard; Thelestam Monica
A cellular deficiency of gangliosides causes hypersensitivity to Clostridium perfringens phospholipase C.
The Journal of biological chemistry 2005;280(29):26680-9.
2005: Taylor Victoria L; Titball Richard W; Oyston Petra C F
Oral immunization with a dam mutant of Yersinia pseudotuberculosis protects against plague.
Microbiology (Reading, England) 2005;151(Pt 6):1919-26.
2005: Garmory Helen S; Perkins Stuart D; Phillpotts Robert J; Titball Richard W
DNA vaccines for biodefence.
Advanced drug delivery reviews 2005;57(9):1343-61.
2005: Isherwood Karen E; Titball Richard W; Davies D Huw; Felgner Phillip L; Morrow W John W
Vaccination strategies for Francisella tularensis.
Advanced drug delivery reviews 2005;57(9):1403-14.
2005: Harland David N; Garmory Helen S; Brown Katherine A; Titball Richard W
An association between ATP binding cassette systems, genome sizes and lifestyles of bacteria.
Research in microbiology 2005;156(3):434-42.
2005: Keith Karen E; Oyston Petra C; Crossett Ben; Fairweather Neil F; Titball Richard W; Walsh Timothy R; Brown Katherine A
Functional characterization of OXA-57, a class D beta-lactamase from Burkholderia pseudomallei.
Antimicrobial agents and chemotherapy 2005;49(4):1639-41.
2005: Green Michael; Choules Glyn; Rogers Debbie; Titball Richard W
Efficacy of the live attenuated Francisella tularensis vaccine (LVS) in a murine model of disease.
Vaccine 2005;23(20):2680-6.
2005: Griffin Kate; Bedford Richard; Townson Kate; Phillpotts Robert; Funnell Simon; Morton Margret; Williamson Diane; Titball Richard
Protective efficacy of a recombinant plague vaccine when co-administered with another sub-unit or live attenuated vaccine.
FEMS immunology and medical microbiology 2005;43(3):425-30.
2005: Rees D G Cerys; Gates Amanda J; Green Michael; Eastaugh Lin; Lukaszewski Roman A; Griffin Kate F; Krieg Arthur M; Titball Richard W
CpG-DNA protects against a lethal orthopoxvirus infection in a murine model.
Antiviral research 2005;65(2):87-95.
2005: Essex-Lopresti Angela E; Boddey Justin A; Thomas Richard; Smith Martin P; Hartley M Gill; Atkins Timothy; Brown Nat F; Tsang Chuk Hai; Peak Ian R A; Hill Jim; Beacham Ifor R; Titball Richard W
A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
Infection and immunity 2005;73(2):1260-4.
2005: Larsson Pär; Oyston Petra C F; Chain Patrick; Chu May C; Duffield Melanie; Fuxelius Hans-Henrik; Garcia Emilio; Hälltorp Greger; Johansson Daniel; Isherwood Karen E; Karp Peter D; Larsson Eva; Liu Ying; Michell Stephen; Prior Joann; Prior Richard; Malfatti Stephanie; Sjöstedt Anders; Svensson Kerstin; Thompson Nick; Vergez Lisa; Wagg Jonathan K; Wren Brendan W; Lindler Luther E; Andersson Siv G E; Forsman Mats; Titball Richard W
The complete genome sequence of Francisella tularensis, the causative agent of tularemia.
Nature genetics 2005;37(2):153-9.
2004: Nelson Michelle; Prior Joann L; Lever M Stephen; Jones Helen E; Atkins Timothy P; Titball Richard W
Evaluation of lipopolysaccharide and capsular polysaccharide as subunit vaccines against experimental melioidosis.
Journal of medical microbiology 2004;53(Pt 12):1177-82.
2004: Garmory Helen S; Titball Richard W
ATP-binding cassette transporters are targets for the development of antibacterial vaccines and therapies.
Infection and immunity 2004;72(12):6757-63.
2004: Oyston Petra C F; Sjostedt Anders; Titball Richard W
Tularaemia: bioterrorism defence renews interest in Francisella tularensis.
Nature reviews. Microbiology 2004;2(12):967-78.
2004: Holden Matthew T G; Titball Richard W; Peacock Sharon J; Cerdeño-Tárraga Ana M; Atkins Timothy; Crossman Lisa C; Pitt Tyrone; Churcher Carol; Mungall Karen; Bentley Stephen D; Sebaihia Mohammed; Thomson Nicholas R; Bason Nathalie; Beacham Ifor R; Brooks Karen; Brown Katherine A; Brown Nat F; Challis Greg L; Cherevach Inna; Chillingworth Tracy; Cronin Ann; Crossett Ben; Davis Paul; DeShazer David; Feltwell Theresa; Fraser Audrey; Hance Zahra; Hauser Heidi; Holroyd Simon; Jagels Kay; Keith Karen E; Maddison Mark; Moule Sharon; Price Claire; Quail Michael A; Rabbinowitsch Ester; Rutherford Kim; Sanders Mandy; Simmonds Mark; Songsivilai Sirirurg; Stevens Kim; Tumapa Sarinna; Vesaratchavest Monkgol; Whitehead Sally; Yeats Corin; Barrell Bart G; Oyston Petra C F; Parkhill Julian
Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(39):14240-5.
2004: Hambrook Joy; Titball Richard; Lindsay Christopher
The interaction of Pseudomonas aeruginosa PAK with human and animal respiratory tract cell lines.
FEMS microbiology letters 2004;238(1):49-55.
2004: Mutebi John-Paul; Rijnbrand René C A; Wang Heiman; Ryman Kate D; Wang Eryu; Fulop Lynda D; Titball Rick; Barrett Alan D T
Genetic relationships and evolution of genotypes of yellow fever virus and other members of the yellow fever virus group within the Flavivirus genus based on the 3' noncoding region.
Journal of virology 2004;78(18):9652-65.
2004: Stevens Mark P; Haque Ashraful; Atkins Timothy; Hill Jim; Wood Michael W; Easton Anna; Nelson Michelle; Underwood-Fowler Cindy; Titball Richard W; Bancroft Gregory J; Galyov Edouard E
Attenuated virulence and protective efficacy of a Burkholderia pseudomallei bsa type III secretion mutant in murine models of melioidosis.
Microbiology (Reading, England) 2004;150(Pt 8):2669-76.
2004: Stevens Dennis L; Titball Richard W; Jepson Marie; Bayer Clifford R; Hayes-Schroer Susan M; Bryant Amy E
Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens.
The Journal of infectious diseases 2004;190(4):767-73.
2004: Cole Ambrose R; Gibert Maryse; Popoff Michel; Moss David S; Titball Richard W; Basak Ajit K
Clostridium perfringens epsilon-toxin shows structural similarity to the pore-forming toxin aerolysin.
Nature structural & molecular biology 2004;11(8):797-8.
2004: Hartley M G; Green M; Choules G; Rogers D; Rees D G C; Newstead S; Sjostedt A; Titball R W
Protection afforded by heat shock protein 60 from Francisella tularensis is due to copurified lipopolysaccharide.
Infection and immunity 2004;72(7):4109-13.
2004: Morton Margaret; Garmory Helen S; Perkins Stuart D; O'Dowd Aisling M; Griffin Kate F; Turner Arthur K; Bennett Alice M; Titball Richard W
A Salmonella enterica serovar Typhi vaccine expressing Yersinia pestis F1 antigen on its surface provides protection against plague in mice.
Vaccine 2004;22(20):2524-32.
2004: Titball Richard W; Williamson E Diane
Yersinia pestis (plague) vaccines.
Expert opinion on biological therapy 2004;4(6):965-73.
2004: Laws Thomas R; Harding Sarah V; Smith Martin P; Atkins Timothy P; Titball Richard W
Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria.
FEMS microbiology letters 2004;234(2):281-7.
2004: Flores-Díaz Marietta; Thelestam Monica; Clark Graeme C; Titball Richard W; Alape-Girón Alberto
Effects of Clostridium perfringens phospholipase C in mammalian cells.
Anaerobe 2004;10(2):115-23.
2004: Garmory Helen S; Freeman Donna; Brown Katherine A; Titball Richard W
Protection against plague afforded by immunisation with DNA vaccines optimised for expression of the Yersinia pestis V antigen.
Vaccine 2004;22(8):947-57.
2004: Gilbert M Thomas P; Cuccui Jon; White William; Lynnerup Niels; Titball Richard W; Cooper Alan; Prentice Michael B
Absence of Yersinia pestis-specific DNA in human teeth from five European excavations of putative plague victims.
Microbiology (Reading, England) 2004;150(Pt 2):341-54.
2003: Lever M Stephen; Nelson Michelle; Ireland Philip I; Stagg Anthony J; Beedham Richard J; Hall Graham A; Knight Georgina; Titball Richard W
Experimental aerogenic Burkholderia mallei (glanders) infection in the BALB/c mouse.
Journal of medical microbiology 2003;52(Pt 12):1109-15.
2003: Beal Dominic R; Titball Richard W; Lindsay Christopher D
The development of tolerance to Clostridium perfringens type D epsilon-toxin in MDCK and G-402 cells.
Human & experimental toxicology 2003;22(11):593-605.
2003: Joshua G W P; Karlyshev A V; Smith M P; Isherwood K E; Titball R W; Wren B W
A Caenorhabditis elegans model of Yersinia infection: biofilm formation on a biotic surface.
Microbiology (Reading, England) 2003;149(Pt 11):3221-9.
2003: Clark Graeme C; Briggs David C; Karasawa Tadahiro; Wang Xingmin; Cole Ambrose R; Maegawa Tsuneo; Jayasekera Pramukh N; Naylor Claire E; Miller Julie; Moss David S; Nakamura Shinichi; Basak Ajit K; Titball Richard W
Clostridium absonum alpha-toxin: new insights into clostridial phospholipase C substrate binding and specificity.
Journal of molecular biology 2003;333(4):759-69.
2003: Prior Joann L; Prior Richard G; Hitchen Paul G; Diaper Helen; Griffin Kate F; Morris Howard R; Dell Anne; Titball Richard W
Characterization of the O antigen gene cluster and structural analysis of the O antigen of Francisella tularensis subsp. tularensis.
Journal of medical microbiology 2003;52(Pt 10):845-51.
2003: Titball R W; Williamson E D
Vaccine development for potential bioterrorism agents.
Current drug targets. Infectious disorders 2003;3(3):255-62.
2003: Hinchliffe Stewart J; Isherwood Karen E; Stabler Richard A; Prentice Michael B; Rakin Alexander; Nichols Richard A; Oyston Petra C F; Hinds Jason; Titball Richard W; Wren Brendan W
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis.
Genome research 2003;13(9):2018-29.
2003: Waters Michael; Savoie Amanda; Garmory Helen S; Bueschel Dawn; Popoff Michel R; Songer J Glenn; Titball Richard W; McClane Bruce A; Sarker Mahfuzur R
Genotyping and phenotyping of beta2-toxigenic Clostridium perfringens fecal isolates associated with gastrointestinal diseases in piglets.
Journal of clinical microbiology 2003;41(8):3584-91.
2003: Broekhuijsen Martien; Larsson Pär; Johansson Anders; Byström Mona; Eriksson Ulla; Larsson Eva; Prior Richard G; Sjöstedt Anders; Titball Richard W; Forsman Mats
Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis.
Journal of clinical microbiology 2003;41(7):2924-31.
2003: Titball R W; Oyston P C F
A vaccine for tularaemia.
Expert opinion on biological therapy 2003;3(4):645-53.
2003: Garmory Helen S; Titball Richard W; Griffin Kate F; Hahn Ulrike; Böhm Reinhard; Beyer Wolfgang
Salmonella enterica serovar typhimurium expressing a chromosomally integrated copy of the Bacillus anthracis protective antigen gene protects mice against an anthrax spore challenge.
Infection and immunity 2003;71(7):3831-6.
2003: Garmory Helen S; Griffin Kate F; Brown Katherine A; Titball Richard W
Oral immunisation with live aroA attenuated Salmonella enterica serovar Typhimurium expressing the Yersinia pestis V antigen protects mice against plague.
Vaccine 2003;21(21-22):3051-7.
2003: Donelli Gianfranco; Fiorentini Carla; Matarrese Paola; Falzano Loredana; Cardines Rita; Mastrantonio Paola; Payne Dean W; Titball Richard W
Evidence for cytoskeletal changes secondary to plasma membrane functional alterations in the in vitro cell response to Clostridium perfringens epsilon-toxin.
Comparative immunology, microbiology and infectious diseases 2003;26(3):145-56.
2003: Oyston P C F; Prior J L; Kiljunen S; Skurnik M; Hill J; Titball R W
Expression of heterologous O-antigen in Yersinia pestis KIM does not affect virulence by the intravenous route.
Journal of medical microbiology 2003;52(Pt 4):289-94.
2003: Hill Jim; Copse Catherine; Leary Sophie; Stagg Anthony J; Williamson E Diane; Titball Richard W
Synergistic protection of mice against plague with monoclonal antibodies specific for the F1 and V antigens of Yersinia pestis.
Infection and immunity 2003;71(4):2234-8.
2003: Titball Richard W; Johansson Anders; Forsman Mats
Will the enigma of Francisella tularensis virulence soon be solved?
Trends in microbiology 2003;11(3):118-23.
2003: Garmory Helen S; Titball Richard W; Brown Katherine A; Bennett Alice M
Construction and evaluation of a eukaryotic expression plasmid for stable delivery using attenuated Salmonella.
Microbial pathogenesis 2003;34(3):115-9.
2003: Foynes Susan; Holley Jane L; Garmory Helen S; Titball Richard W; Fairweather Neil F
Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H(C) fragment.
Vaccine 2003;21(11-12):1052-9.
2003: Titball R W; Hill J; Lawton D G; Brown K A
Yersinia pestis and plague.
Biochemical Society transactions 2003;31(Pt 1):104-7.
2003: Thomas Rebecca; Johansson Anders; Neeson Brendan; Isherwood Karen; Sjöstedt Anders; Ellis Jill; Titball Richard W
Discrimination of human pathogenic subspecies of Francisella tularensis by using restriction fragment length polymorphism.
Journal of clinical microbiology 2003;41(1):50-7.
2003: Mayers Carl; Duffield Melanie; Rowe Sonya; Miller Julie; Lingard Bryan; Hayward Sarah; Titball Richard W
Analysis of known bacterial protein vaccine antigens reveals biased physical properties and amino Acid composition.
Comparative and functional genomics 2003;4(5):468-78.
2003: Garmory Helen S; Leary Sophie E C; Griffin Kate F; Williamson E Diane; Brown Katherine A; Titball Richard W
The use of live attenuated bacteria as a delivery system for heterologous antigens.
Journal of drug targeting 2003;11(8-10):471-9.
2003: Hill James; Underwood Cindy D; Sundberg Lena; Aström Hanna; Leary Sophie E C; Forsberg Ake; Titball Richard W
Immunological characterisation of sub-units of the Yersinia type III secretion apparatus.
Advances in experimental medicine and biology 2003;529():415-7.
2003: Titball Richard W; Williamson E Diane
Second and third generation plague vaccines.
Advances in experimental medicine and biology 2003;529():397-406.
2003: Stabler Richard A; Hinds Jason; Witney Adam A; Isherwood Karen; Oyston Petra; Titball Richard; Wren Brendan; Hinchliffe Stewart; Prentice Michael; Mangan Joseph A; Butcher Phillip D
Construction of a Yersinia pestis microarray.
Advances in experimental medicine and biology 2003;529():47-9.
2003: Oyston Petra C F; Karlyshev Andrey V; Wren Brendan W; Titball Richard W
Signature-tagged mutagenesis of Yersinia pestis.
Advances in experimental medicine and biology 2003;529():39-41.
2003: Taylor Victoria L; Oyston Petra C F; Titball Richard W
DNA adenine methylation.
Advances in experimental medicine and biology 2003;529():13-7.
2002: Garmory Helen S; Brown Katherine A; Titball Richard W
Salmonella vaccines for use in humans: present and future perspectives.
FEMS microbiology reviews 2002;26(4):339-53.
2002: Ellis Jill; Oyston Petra C F; Green Michael; Titball Richard W
Tularemia.
Clinical microbiology reviews 2002;15(4):631-46.
2002: Lawton Daniel G; Longstaff Colin; Wallace B A; Hill Jim; Leary Sophie E C; Titball Richard W; Brown Katherine A
Interactions of the type III secretion pathway proteins LcrV and LcrG from Yersinia pestis are mediated by coiled-coil domains.
The Journal of biological chemistry 2002;277(41):38714-22.
2002: Garmory Helen S; Griffin Kate F; Leary Sophie E C; Perkins Stuart D; Brown Katherine A; Titball Richard W
The effect of recombinant plasmids on in vivo colonisation of Salmonella enterica serovar Typhimurium strains is not reflected by in vitro cellular invasion assays.
Vaccine 2002;20(27-28):3239-43.
2002: Atkins T; Prior R G; Mack K; Russell P; Nelson M; Oyston P C F; Dougan G; Titball R W
A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis.
Infection and immunity 2002;70(9):5290-4.
2002: Prior J L; Titball R W
Monoclonal antibodies against Yersinia pestis lipopolysaccharide detect bacteria cultured at 28 degrees C or 37 degrees C.
Molecular and cellular probes 2002;16(4):251-6.
2002: Atkins Timothy; Prior Richard; Mack Kerri; Russell Paul; Nelson Michelle; Prior Joann; Ellis Jill; Oyston Petra C F; Dougan Gordon; Titball Richard W
Characterisation of an acapsular mutant of Burkholderia pseudomallei identified by signature tagged mutagenesis.
Journal of medical microbiology 2002;51(7):539-47.
2002: Howells Angela M; Bullifent Helen L; Dhaliwal Kam; Griffin Kate; García de Castro Arcadio; Frith Graeme; Tunnacliffe Alan; Titball Richard W
Role of trehalose biosynthesis in environmental survival and virulence of Salmonella enterica serovar typhimurium.
Research in microbiology 2002;153(5):281-7.
2002: Hitchen Paul G; Prior Joann L; Oyston Petra C F; Panico Maria; Wren Brendan W; Titball Richard W; Morris Howard R; Dell Anne
Structural characterization of lipo-oligosaccharide (LOS) from Yersinia pestis: regulation of LOS structure by the PhoPQ system.
Molecular microbiology 2002;44(6):1637-50.
2002: Eaton Julian T; Naylor Claire E; Howells Angela M; Moss David S; Titball Richard W; Basak Ajit K
Crystal structure of the C. perfringens alpha-toxin with the active site closed by a flexible loop region.
Journal of molecular biology 2002;319(2):275-81.
2002: Smith Martin P; Laws Thomas R; Atkins Timothy P; Oyston Petra C F; de Pomerai David I; Titball Richard W
A liquid-based method for the assessment of bacterial pathogenicity using the nematode Caenorhabditis elegans.
FEMS microbiology letters 2002;210(2):181-5.
2002: Justin Neil; Walker Nicola; Bullifent Helen L; Songer Glenn; Bueschel Dawn M; Jost Helen; Naylor Claire; Miller Julie; Moss David S; Titball Richard W; Basak Ajit K
The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.
Biochemistry 2002;41(20):6253-62.
2002: Flick-Smith Helen C; Walker Nicola J; Gibson Paula; Bullifent Helen; Hayward Sarah; Miller Julie; Titball Richard W; Williamson E Diane
A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection.
Infection and immunity 2002;70(3):1653-6.
2002: Baker Matthew D; Papageorgiou Anastassios C; Titball Richard W; Miller Julie; White Sarah; Lingard Bryan; Lee Jeong Jin; Cavanagh David; Kehoe Michael A; Robinson John H; Acharya K Ravi
Structural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin B.
The Journal of biological chemistry 2002;277(4):2756-62.
2002: Williamson E D; Titball R W
Vaccines against dangerous pathogens.
British medical bulletin 2002;62():163-73.
2001: Tito M A; Miller J; Walker N; Griffin K F; Williamson E D; Despeyroux-Hill D; Titball R W; Robinson C V
Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach.
Biophysical journal 2001;81(6):3503-9.
2001: Karlyshev A V; Oyston P C; Williams K; Clark G C; Titball R W; Winzeler E A; Wren B W
Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes.
Infection and immunity 2001;69(12):7810-9.
2001: Tito M A; Miller J; Griffin K F; Williamson E D; Titball R W; Robinson C V
Macromolecular organization of the Yersinia pestis capsular F1 antigen: insights from time-of-flight mass spectrometry.
Protein science : a publication of the Protein Society 2001;10(11):2408-13.
2001: Parkhill J; Wren B W; Thomson N R; Titball R W; Holden M T; Prentice M B; Sebaihia M; James K D; Churcher C; Mungall K L; Baker S; Basham D; Bentley S D; Brooks K; Cerdeño-Tárraga A M; Chillingworth T; Cronin A; Davies R M; Davis P; Dougan G; Feltwell T; Hamlin N; Holroyd S; Jagels K; Karlyshev A V; Leather S; Moule S; Oyston P C; Quail M; Rutherford K; Simmonds M; Skelton J; Stevens K; Whitehead S; Barrell B G
Genome sequence of Yersinia pestis, the causative agent of plague.
Nature 2001;413(6855):523-7.
2001: Prior R G; Klasson L; Larsson P; Williams K; Lindler L; Sjöstedt A; Svensson T; Tamas I; Wren B W; Oyston P C; Andersson S G; Titball R W
Preliminary analysis and annotation of the partial genome sequence of Francisella tularensis strain Schu 4.
Journal of applied microbiology 2001;91(4):614-20.
2001: Fulop M; Mastroeni P; Green M; Titball R W
Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis.
Vaccine 2001;19(31):4465-72.
2001: Titball R W; Williamson E D
Vaccination against bubonic and pneumonic plague.
Vaccine 2001;19(30):4175-84.
2001: Jepson M; Bullifent H L; Crane D; Flores-Diaz M; Alape-Giron A; Jayasekeera P; Lingard B; Moss D; Titball R W
Tyrosine 331 and phenylalanine 334 in Clostridium perfringens alpha-toxin are essential for cytotoxic activity.
FEBS letters 2001;495(3):172-7.
2001: Prior J L; Parkhill J; Hitchen P G; Mungall K L; Stevens K; Morris H R; Reason A J; Oyston P C; Dell A; Wren B W; Titball R W
The failure of different strains of Yersinia pestis to produce lipopolysaccharide O-antigen under different growth conditions is due to mutations in the O-antigen gene cluster.
FEMS microbiology letters 2001;197(2):229-33.
2001: Prentice M B; James K D; Parkhill J; Baker S G; Stevens K; Simmonds M N; Mungall K L; Churcher C; Oyston P C; Titball R W; Wren B W; Wain J; Pickard D; Hien T T; Farrar J J; Dougan G
Yersinia pestis pFra shows biovar-specific differences and recent common ancestry with a Salmonella enterica serovar Typhi plasmid.
Journal of bacteriology 2001;183(8):2586-94.
2001: Prior J L; Hitchen P G; Williamson D E; Reason A J; Morris H R; Dell A; Wren B W; Titball R W
Characterization of the lipopolysaccharide of Yersinia pestis.
Microbial pathogenesis 2001;30(2):49-57.
2000: Walker N; Holley J; Naylor C E; Flores-Díaz M; Alape-Girón A; Carter G; Carr F J; Thelestam M; Keyte M; Moss D S; Basak A K; Miller J; Titball R W
Identification of residues in the carboxy-terminal domain of Clostridium perfringens alpha-toxin (phospholipase C) which are required for its biological activities.
Archives of biochemistry and biophysics 2000;384(1):24-30.
2000: Bullifent H L; Dhaliwal K; Howells A M; Goan K; Griffin K; Lindsay C D; Tunnacliffe A; Titball R W
Stabilisation of Salmonella vaccine vectors by the induction of trehalose biosynthesis.
Vaccine 2000;19(9-10):1239-45.
2000: Titball R W; Naylor C E; Miller J; Moss D S; Basak A K
Opening of the active site of Clostridium perfringens alpha-toxin may be triggered by membrane binding.
International journal of medical microbiology : IJMM 2000;290(4-5):357-61.
2000: Williamson E D; Eley S M; Stagg A J; Green M; Russell P; Titball R W
A single dose sub-unit vaccine protects against pneumonic plague.
Vaccine 2000;19(4-5):566-71.
2000: Holley J L; Elmore M; Mauchline M; Minton N; Titball R W
Cloning, expression and evaluation of a recombinant sub-unit vaccine against Clostridium botulinum type F toxin.
Vaccine 2000;19(2-3):288-97.
2000: Alape-Girón A; Flores-Díaz M; Guillouard I; Naylor C E; Titball R W; Rucavado A; Lomonte B; Basak A K; Gutiérrez J M; Cole S T; Thelestam M
Identification of residues critical for toxicity in Clostridium perfringens phospholipase C, the key toxin in gas gangrene.
European journal of biochemistry / FEBS 2000;267(16):5191-7.
2000: Russell P; Eley S M; Ellis J; Green M; Bell D L; Kenny D J; Titball R W
Comparison of efficacy of ciprofloxacin and doxycycline against experimental melioidosis and glanders.
The Journal of antimicrobial chemotherapy 2000;45(6):813-8.
2000: Oyston P C; Dorrell N; Williams K; Li S R; Green M; Titball R W; Wren B W
The response regulator PhoP is important for survival under conditions of macrophage-induced stress and virulence in Yersinia pestis.
Infection and immunity 2000;68(6):3419-25.
2000: Bullifent H L; Griffin K F; Jones S M; Yates A; Harrington L; Titball R W
Antibody responses to Yersinia pestis F1-antigen expressed in Salmonella typhimurium aroA from in vivo-inducible promoters.
Vaccine 2000;18(24):2668-76.
2000: Williams K; Oyston P C; Dorrell N; Li S; Titball R W; Wren B W
Investigation into the role of the serine protease HtrA in Yersinia pestis pathogenesis.
FEMS microbiology letters 2000;186(2):281-6.
2000: Byrne M P; Titball R W; Holley J; Smith L A
Fermentation, purification, and efficacy of a recombinant vaccine candidate against botulinum neurotoxin type F from Pichia pastoris.
Protein expression and purification 2000;18(3):327-37.
2000: Wright A; Andrews P L; Titball R W
Induction of emetic, pyrexic, and behavioral effects of Staphylococcus aureus enterotoxin B in the ferret.
Infection and immunity 2000;68(4):2386-9.
2000: Shortt S J; Titball R W; Lindsay C D
An assessment of the in vitro toxicology of Clostridium perfringens type D epsilon-toxin in human and animal cells.
Human & experimental toxicology 2000;19(2):108-16.
2000: Garmory H S; Chanter N; French N P; Bueschel D; Songer J G; Titball R W
Occurrence of Clostridium perfringens beta2-toxin amongst animals, determined using genotyping and subtyping PCR assays.
Epidemiology and infection 2000;124(1):61-7.
2000: Karlsson J; Prior R G; Williams K; Lindler L; Brown K A; Chatwell N; Hjalmarsson K; Loman N; Mack K A; Pallen M; Popek M; Sandström G; Sjöstedt A; Svensson T; Tamas I; Andersson S G; Wren B W; Oyston P C; Titball R W
Sequencing of the Francisella tularensis strain Schu 4 genome reveals the shikimate and purine metabolic pathways, targets for the construction of a rationally attenuated auxotrophic vaccine.
Microbial & comparative genomics 2000;5(1):25-39.
1999: Naylor C E; Jepson M; Crane D T; Titball R W; Miller J; Basak A K; Bolgiano B
Characterisation of the calcium-binding C-terminal domain of Clostridium perfringens alpha-toxin.
Journal of molecular biology 1999;294(3):757-70.
1999: Kenny D J; Russell P; Rogers D; Eley S M; Titball R W
In vitro susceptibilities of Burkholderia mallei in comparison to those of other pathogenic Burkholderia spp.
Antimicrobial agents and chemotherapy 1999;43(11):2773-5.
1999: Jepson M; Howells A; Bullifent H L; Bolgiano B; Crane D; Miller J; Holley J; Jayasekera P; Titball R W
Differences in the carboxy-terminal (Putative phospholipid binding) domains of Clostridium perfringens and Clostridium bifermentans phospholipases C influence the hemolytic and lethal properties of these enzymes.
Infection and immunity 1999;67(7):3297-301.
1999: Pettersson J; Holmström A; Hill J; Leary S; Frithz-Lindsten E; von Euler-Matell A; Carlsson E; Titball R; Forsberg A; Wolf-Watz H
The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation.
Molecular microbiology 1999;32(5):961-76.
1999: Titball R W; Naylor C E; Basak A K
The Clostridium perfringens alpha-toxin.
Anaerobe 1999;5(2):51-64.
1999: Williamson E D; Vesey P M; Gillhespy K J; Eley S M; Green M; Titball R W
An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse model.
Clinical and experimental immunology 1999;116(1):107-14.
1999: Leary S E; Griffin K F; Galyov E E; Hewer J; Williamson E D; Holmström A; Forsberg A; Titball R W
Yersinia outer proteins (YOPS) E, K and N are antigenic but non-protective compared to V antigen, in a murine model of bubonic plague.
Microbial pathogenesis 1999;26(3):159-69.
1999: Green M; Rogers D; Russell P; Stagg A J; Bell D L; Eley S M; Titball R W; Williamson E D
The SCID/Beige mouse as a model to investigate protection against Yersinia pestis.
FEMS immunology and medical microbiology 1999;23(2):107-13.
1999: Bennett A M; Lescott T; Phillpotts R J; Mackett M; Titball R W
Recombinant vaccinia viruses protect against Clostridium perfringens alpha-toxin.
Viral immunology 1999;12(2):97-105.
1998: Basak A K; Howells A; Eaton J T; Moss D S; Naylor C E; Miller J; Titball R W
Crystallization and preliminary X-ray diffraction studies of alpha-toxin from two different strains (NCTC8237 and CER89L43) of Clostridium perfringens.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1425-8.
1998: Carter G; White P; Fernie M; King S; McLean G; Titball R; Carr F J
Enhanced antitumour effect of liposomal daunorubicin using antibody-phospholipase C conjugates or fusion protein.
International journal of oncology 1998;13(4):819-25.
1998: Flores-Díaz M; Alape-Girón A; Titball R W; Moos M; Guillouard I; Cole S; Howells A M; von Eichel-Streiber C; Florin I; Thelestam M
UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C.
The Journal of biological chemistry 1998;273(38):24433-8.
1998: Payne D; Tatham D; Williamson E D; Titball R W
The pH 6 antigen of Yersinia pestis binds to beta1-linked galactosyl residues in glycosphingolipids.
Infection and immunity 1998;66(9):4545-8.
1998: Naylor C E; Eaton J T; Howells A; Justin N; Moss D S; Titball R W; Basak A K
Structure of the key toxin in gas gangrene.
Nature structural biology 1998;5(8):738-46.
1998: Miller J; Williamson E D; Lakey J H; Pearce M J; Jones S M; Titball R W
Macromolecular organisation of recombinant Yersinia pestis F1 antigen and the effect of structure on immunogenicity.
FEMS immunology and medical microbiology 1998;21(3):213-21.
1998: Mack K; Titball R W
The detection of insertion sequences within the human pathogen Burkholderia pseudomallei which have been identified previously in Burkholderia cepacia.
FEMS microbiology letters 1998;162(1):69-74.
1998: Russell P; Eley S M; Fulop M J; Bell D L; Titball R W
The efficacy of ciprofloxacin and doxycycline against experimental tularaemia.
The Journal of antimicrobial chemotherapy 1998;41(4):461-5.
1998: Russell P; Eley S M; Green M; Stagg A J; Taylor R R; Nelson M; Beedham R J; Bell D L; Rogers D; Whittington D; Titball R W
Efficacy of doxycycline and ciprofloxacin against experimental Yersinia pestis infection.
The Journal of antimicrobial chemotherapy 1998;41(2):301-5.
1998: Oyston P C; Payne D W; Havard H L; Williamson E D; Titball R W
Production of a non-toxic site-directed mutant of Clostridium perfringens epsilon-toxin which induces protective immunity in mice.
Microbiology (Reading, England) 1998;144 ( Pt 2)():333-41.
1998: Titball R W; Leary S E
Plague.
British medical bulletin 1998;54(3):625-33.
1998: Titball R W
Bacterial phospholipases.
Symposium series (Society for Applied Microbiology) 1998;27():127S-137S.
1997: Russell P; Nelson M; Whittington D; Green M; Eley S M; Titball R W
Laboratory diagnosis of plague.
British journal of biomedical science 1997;54(4):231-6.
1997: Hill J; Leary S E; Griffin K F; Williamson E D; Titball R W
Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization.
Infection and immunity 1997;65(11):4476-82.
1997: Leary S E; Griffin K F; Garmory H S; Williamson E D; Titball R W
Expression of an F1/V fusion protein in attenuated Salmonella typhimurium and protection of mice against plague.
Microbial pathogenesis 1997;23(3):167-79.
1997: Williamson E D; Eley S M; Stagg A J; Green M; Russell P; Titball R W
A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plague.
Vaccine 1997;15(10):1079-84.
1997: Titball R W
Bacterial phospholipases.
Trends in microbiology 1997;5(7):265.
1997: Titball R W; Howells A M; Oyston P C; Williamson E D
Expression of the Yersinia pestis capsular antigen (F1 antigen) on the surface of an aroA mutant of Salmonella typhimurium induces high levels of protection against plague.
Infection and immunity 1997;65(5):1926-30.
1996: Williamson E D; Sharp G J; Eley S M; Vesey P M; Pepper T C; Titball R W; Alpar H O
Local and systemic immune response to a microencapsulated sub-unit vaccine for plague.
Vaccine 1996;14(17-18):1613-9.
1996: Mack K; Titball R W
Transformation of Burkholderia pseudomallei by electroporation.
Analytical biochemistry 1996;242(1):73-6.
1996: Anderson G W; Leary S E; Williamson E D; Titball R W; Welkos S L; Worsham P L; Friedlander A M
Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule-positive and -negative strains of Yersinia pestis.
Infection and immunity 1996;64(11):4580-5.
1996: McGregor D P; Forster S; Steven J; Adair J; Leary S E; Leslie D L; Harris W J; Titball R W
Simultaneous detection of microorganisms in soil suspension based on PCR amplification of bacterial 16S rRNA fragments.
BioTechniques 1996;21(3):463-6, 468, 470-1.
1996: Oyston P C; Russell P; Williamson E D; Titball R W
An aroA mutant of Yersinia pestis is attenuated in guinea-pigs, but virulent in mice.
Microbiology (Reading, England) 1996;142 ( Pt 7)():1847-53.
1996: Russell P; Eley S M; Bell D L; Manchee R J; Titball R W
Doxycycline or ciprofloxacin prophylaxis and therapy against experimental Yersinia pestis infection in mice.
The Journal of antimicrobial chemotherapy 1996;37(4):769-74.
1996: Ivanov A; Titball R W; Kostadinova S
Characterisation of a phospholipase C produced by Pseudomonas fluorescens.
The new microbiologica : official journal of the Italian Society for Medical, Odontoiatric, and Clinical Microbiology (SIMMOC) 1996;19(2):113-21.
1996: Fulop M; Leslie D; Titball R
A rapid, highly sensitive method for the detection of Francisella tularensis in clinical samples using the polymerase chain reaction.
The American journal of tropical medicine and hygiene 1996;54(4):364-6.
1996: Fulop M; Manchee R; Titball R
Role of two outer membrane antigens in the induction of protective immunity against Francisella tularensis strains of different virulence.
FEMS immunology and medical microbiology 1996;13(3):245-7.
1996: Ginter A; Williamson E D; Dessy F; Coppe P; Bullifent H; Howells A; Titball R W
Molecular variation between the alpha-toxins from the type strain (NCTC 8237) and clinical isolates of Clostridium perfringens associated with disease in man and animals.
Microbiology (Reading, England) 1996;142 ( Pt 1)():191-8.
1995: Russell P; Eley S M; Hibbs S E; Manchee R J; Stagg A J; Titball R W
A comparison of Plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine model.
Vaccine 1995;13(16):1551-6.
1995: Fulop M; Manchee R; Titball R
Role of lipopolysaccharide and a major outer membrane protein from Francisella tularensis in the induction of immunity against tularemia.
Vaccine 1995;13(13):1220-5.
1995: Fulop L D; Barrett A D; Titball R W
Nucleotide sequence of the NS5 gene of Banzi virus: comparison with other flaviviruses.
The Journal of general virology 1995;76 ( Pt 9)():2317-21.
1995: Leary S E; Williamson E D; Griffin K F; Russell P; Eley S M; Titball R W
Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague.
Infection and immunity 1995;63(8):2854-8.
1995: Bullifent H L; Moir A; Titball R W
The construction of a reporter system and use for the investigation of Clostridium perfringens gene expression.
FEMS microbiology letters 1995;131(1):99-105.
1995: Oyston P C; Williamson E D; Leary S E; Eley S M; Griffin K F; Titball R W
Immunization with live recombinant Salmonella typhimurium aroA producing F1 antigen protects against plague.
Infection and immunity 1995;63(2):563-8.
1995: Leary S E; Eley S M; Williamson E D; Titball R W
Expression of Yersinia pestis V antigen in attenuated salmonella typhimurium: development of a novel vaccine for plague.
Contributions to microbiology and immunology 1995;13():216-7.
1994: Basak A K; Stuart D I; Nikura T; Bishop D H; Kelly D C; Fearn A; Titball R W
Purification, crystallization and preliminary X-ray diffraction studies of alpha-toxin of Clostridium perfringens.
Journal of molecular biology 1994;244(5):648-50.
1994: Tempest P R; White P; Williamson E D; Titball R W; Kelly D C; Kemp G J; Gray P M; Forster S J; Carr F J; Harris W J
Efficient generation of a reshaped human mAb specific for the alpha toxin of Clostridium perfringens.
Protein engineering 1994;7(12):1501-7.
1994: Coulson N M; Fulop M; Titball R W
Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge.
Vaccine 1994;12(15):1395-401.
1994: Coulson N M; Fulop M; Titball R W
Effect of different plasmids on colonization of mouse tissues by the aromatic amino acid dependent Salmonella typhimurium SL 3261.
Microbial pathogenesis 1994;16(4):305-11.
1993: Fulop L; Barrett A D; Phillpotts R; Martin K; Leslie D; Titball R W
Rapid identification of flaviviruses based on conserved NS5 gene sequences.
Journal of virological methods 1993;44(2-3):179-88.
1993: Hunter S E; Brown J E; Oyston P C; Sakurai J; Titball R W
Molecular genetic analysis of beta-toxin of Clostridium perfringens reveals sequence homology with alpha-toxin, gamma-toxin, and leukocidin of Staphylococcus aureus.
Infection and immunity 1993;61(9):3958-65.
1993: Williamson E D; Titball R W
A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects mice against experimental gas gangrene.
Vaccine 1993;11(12):1253-8.
1993: Leslie D L; Cox J; Lee M; Titball R W
Analysis of a cloned Francisella tularensis outer membrane protein gene and expression in attenuated Salmonella typhimurium.
FEMS microbiology letters 1993;111(2-3):331-5.
1993: Titball R W
Bacterial phospholipases C.
Microbiological reviews 1993;57(2):347-66.
1993: Titball R W; Fearn A M; Williamson E D
Biochemical and immunological properties of the C-terminal domain of the alpha-toxin of Clostridium perfringens.
FEMS microbiology letters 1993;110(1):45-50.
1992: Havard H L; Hunter S E; Titball R W
Comparison of the nucleotide sequence and development of a PCR test for the epsilon toxin gene of Clostridium perfringens type B and type D.
FEMS microbiology letters 1992;76(1-2):77-81.
1992: Carl M; Hawkins R; Coulson N; Lowe J; Robertson D L; Nelson W M; Titball R W; Woody J N
Detection of spores of Bacillus anthracis using the polymerase chain reaction.
The Journal of infectious diseases 1992;165(6):1145-8.
1992: Hunter S E; Clarke I N; Kelly D C; Titball R W
Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli.
Infection and immunity 1992;60(1):102-10.
1991: Logan A J; Williamson E D; Titball R W; Percival D A; Shuttleworth A D; Conlan J W; Kelly D C
Epitope mapping of the alpha-toxin of Clostridium perfringens.
Infection and immunity 1991;59(12):4338-42.
1991: Titball R W; Leslie D L; Harvey S; Kelly D
Hemolytic and sphingomyelinase activities of Clostridium perfringens alpha-toxin are dependent on a domain homologous to that of an enzyme from the human arachidonic acid pathway.
Infection and immunity 1991;59(5):1872-4.
1991: Titball R W; Turnbull P C; Hutson R A
The monitoring and detection of Bacillus anthracis in the environment.
Society for Applied Bacteriology symposium series 1991;20():9S-18S.
1990: Titball R W; Rubidge T
The role of histidine residues in the alpha toxin of Clostridium perfringens.
FEMS microbiology letters 1990;56(3):261-5.
1989: Titball R W; Hunter S E; Martin K L; Morris B C; Shuttleworth A D; Rubidge T; Anderson D W; Kelly D C
Molecular cloning and nucleotide sequence of the alpha-toxin (phospholipase C) of Clostridium perfringens.
Infection and immunity 1989;57(2):367-76.
1987: Titball R W; Manchee R J
Factors affecting the germination of spores of Bacillus anthracis.
The Journal of applied bacteriology 1987;62(3):269-73.
1985: Titball R W; Bell A; Munn C B
Role of caseinase from Aeromonas salmonicida in activation of hemolysin.
Infection and immunity 1985;49(3):756-9.
1985: Titball R W; Munn C B
The purification and some properties of H-lysin from Aeromonas salmonicida.
Journal of general microbiology 1985;131(7):1603-9.

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