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Azzaq Belaaouaj

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Physiology

Neutrophil Activation

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Publications

TOP 3
Mathieu Le Gars; Laurette Malleret; Marc Paulais; Delphine Roussel; Manon Ruffin; Emilie Saussereau; Olivier Tabary; Azzaq Belaaouaj; Pierre Boulanger; Michel Chignard; Delphyne Descamps; Aleksander Edelman; Loïc Guillot; Saw See Hong; Michel Huerre; Jean-Michel Sallenave
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
Rym Benabid; Sophie Gangloff; Nicolas Guyot; François Lebargy; Laurette Malleret; Julien Wartelle; Azzaq Belaaouaj
Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia.
Jean-Paul MOTTA; Laurent Magne; Delphyne Descamps; Corinne Rolland; Camila Squarzoni-Dale; Perrine Rousset; Laurence Martin; Nicolas Cenac; Viviane Balloy; Michel Huerre; Leopold F Fröhlich; Dieter Jenne; Julien Wartelle; Azzaq Belaaouaj; Emmanuel Mas; Jean-Pierre Vinel; Laurent Alric; Michel Chignard; Nathalie Vergnolle; Jean-Michel Sallenave
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

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All Publications

2013: Mathieu Le Gars; Laurette Malleret; Marc Paulais; Delphine Roussel; Manon Ruffin; Emilie Saussereau; Olivier Tabary; Azzaq Belaaouaj; Pierre Boulanger; Michel Chignard; Delphyne Descamps; Aleksander Edelman; Loïc Guillot; Saw See Hong; Michel Huerre; Jean-Michel Sallenave
Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.
American journal of respiratory and critical care medicine 2013;187(2):170-9.
2012: Rym Benabid; Sophie Gangloff; Nicolas Guyot; François Lebargy; Laurette Malleret; Julien Wartelle; Azzaq Belaaouaj
Neutrophil elastase modulates cytokine expression: contribution to host defense against Pseudomonas aeruginosa-induced pneumonia.
The Journal of biological chemistry 2012;287(42):34883-94.
2011: Jean-Paul MOTTA; Laurent Magne; Delphyne Descamps; Corinne Rolland; Camila Squarzoni-Dale; Perrine Rousset; Laurence Martin; Nicolas Cenac; Viviane Balloy; Michel Huerre; Leopold F Fröhlich; Dieter Jenne; Julien Wartelle; Azzaq Belaaouaj; Emmanuel Mas; Jean-Pierre Vinel; Laurent Alric; Michel Chignard; Nathalie Vergnolle; Jean-Michel Sallenave
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Gastroenterology 2011;140(4):1272-82.
2010: Denise Al Alam; GAETAN DESLEE; Claire Tournois; Bouchaib Lamkhioued; François Lebargy; Marc Merten; Azzaq Belaaouaj; Moncef Guenounou; Sophie C Gangloff
Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis.
American journal of respiratory cell and molecular biology 2010;42(6):644-50.
2010: Erika C Crouch; Tim O Hirche; Baohai Shao; Rachel Boxio; Julien Wartelle; Rym Benabid; Barbara McDonald; Jay W Heinecke; Sadis Matalon; Azzaq Belaaouaj
Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo.
The Journal of biological chemistry 2010;285(22):16757-70.
2010: Frédéric Velard; Dominique Laurent-Maquin; Julien Braux; Christine Guillaume; Sylvie Bouthors; Edouard Jallot; Jean-Marie Nedelec; Azzaq Belaaouaj; Patrice Laquerriere
The effect of zinc on hydroxyapatite-mediated activation of human polymorphonuclear neutrophils and bone implant-associated acute inflammation.
Biomaterials 2010;31(8):2001-9.
2009: Sinead Weldon; Paul McNally; Noel G McElvaney; J Stuart Elborn; Danny F McAuley; Julien Wartelle; Azzaq Belaaouaj; Rodney L Levine; Clifford Taggart
Decreased levels of secretory leucoprotease inhibitor in the Pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(12):8148-56.
2009: Timofey Kalupov; Michèle Brillard-Bourdet; Sébastien Dadé; Hélène Serrano; Julien Wartelle; Nicolas Guyot; Luiz Juliano; Thierry Moreau; Azzaq Belaaouaj; Francis Gauthier
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.
The Journal of biological chemistry 2009;284(49):34084-91.
2009: Frédéric Velard; Dominique Laurent-Maquin; Christine Guillaume; Sylvie Bouthors; Edouard Jallot; Jean-Marie Nedelec; Azzaq Belaaouaj; Patrice Laquerriere
Polymorphonuclear neutrophil response to hydroxyapatite particles, implication in acute inflammatory reaction.
Acta biomaterialia 2009;5(5):1708-15.
2009: Sadis Matalon; Kedar Shrestha; Marion Kirk; Stephanie Waldheuser; Barbara McDonald; Kelly Smith; Zhiqian Gao; Azzaq Belaaouaj; Erika C Crouch
Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1415-30.
2008: David Bergin; Catherine M Greene; Erwin E Sterchi; Cliona Kenna; Patrick Geraghty; Azzaq Belaaouaj; AZZAQ BELAAOUAJ; Clifford Taggart; Shane J O'Neill; Noel G McElvaney
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway.
The Journal of biological chemistry 2008;283(46):31736-44.
2008: Tim O Hirche; Rym Benabid; GAETAN DESLEE; Sophie C Gangloff; Samuel achilefu; Moncef Guenounou; François Lebargy; Robert E Hancock; Azzaq Belaaouaj
Neutrophil elastase mediates innate host protection against Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):4945-54.
2008: Kai Kessenbrock; Leopold F Fröhlich; Michael Sixt; Tim Lämmermann; Heiko Pfister; Andrew Bateman; Azzaq Belaaouaj; Johannes Ring; Markus Ollert; Reinhard Fässler; Dieter E Jenne
Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin.
The Journal of clinical investigation 2008;118(7):2438-47.
2007: Thomas Baranek; Romain Debret; Frank Antonicelli; Bouchaib Lamkhioued; Azzaq Belaaouaj; William Hornebeck; Philippe Bernard; Moncef Guenounou; Richard Le Naour
Elastin receptor (spliced galactosidase) occupancy by elastin peptides counteracts proinflammatory cytokine expression in lipopolysaccharide-stimulated human monocytes through NF-kappaB down-regulation.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(9):6184-92.
2007: Manling Zhang; Ni Liu; Sun-Mi Park; Yue Wang; Susan Byrne; Andrea E Murmann; Scott Bahr; Marcus E Peter; Steven T Olson; Azzaq Belaaouaj; Philip G Ashton-Rickardt
Serine protease inhibitor 6-deficient mice have increased neutrophil immunity to Pseudomonas aeruginosa.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4390-6.
2007: Patrick Geraghty; Mark P Rogan; Catherine M Greene; Rachel M M Boxio; Tiphaine Poiriert; Michael O'Mahony; Azzaq Belaaouaj; Shane J O'Neill; Clifford Taggart; Noel G McElvaney
Neutrophil elastase up-regulates cathepsin B and matrix metalloprotease-2 expression.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5871-8.
2007: GAETAN DESLEE; Sandra Dury; Jeanne M Perotin; Denise Al Alam; Fabien Vitry; Rachel Boxio; Sophie C Gangloff; Moncef Guenounou; François Lebargy; Azzaq Belaaouaj
Bronchial epithelial spheroids: an alternative culture model to investigate epithelium inflammation-mediated COPD.
Respiratory research 2007;8():86.
2006: Joseph P Gaut; Azzaq Belaaouaj; Jaeman Byun; L Jackson Roberts; Nobuyo Maeda; Balz Frei; Jay W Heinecke
Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation.
Free radical biology & medicine 2006;40(9):1494-501.
2005: Baohai Shao; Azzaq Belaaouaj; Christophe Verlinde; Xiaoyun Fu; Jay W Heinecke
Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase.
The Journal of biological chemistry 2005;280(32):29311-21.
2005: Tim O Hirche; Joseph P Gaut; Jay W Heinecke; Azzaq Belaaouaj
Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1557-65.
2004: Tim O Hirche; Erika C Crouch; Marcia Espinola; Thomas J Brokelman; Robert P Mecham; Nihal DeSilva; Jessica Cooley; Eileen Remold-O'Donnell; Azzaq Belaaouaj
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
The Journal of biological chemistry 2004;279(26):27688-98.
2004: Tim O Hirche; Jefferey J Atkinson; Scott Bahr; Azzaq Belaaouaj
Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites.
American journal of respiratory cell and molecular biology 2004;30(4):576-84.
2004: Yolanda S López-Boado; Marcia Espinola; Scott Bahr; Azzaq Belaaouaj
Neutrophil serine proteinases cleave bacterial flagellin, abrogating its host response-inducing activity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):509-15.
2003: Steven D Shapiro; Nir M Goldstein; A McGarry Houghton; Dale K Kobayashi; Diane Kelley; Azzaq Belaaouaj
Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice.
The American journal of pathology 2003;163(6):2329-35.
2003: Huamei Fu; Azzaq Belaaouaj; Claes Dahlgren; Johan Bylund
Outer membrane protein A deficient Escherichia coli activates neutrophils to produce superoxide and shows increased susceptibility to antibacterial peptides.
Microbes and infection / Institut Pasteur 2003;5(9):781-8.
2002: Azzaq Belaaouaj
Neutrophil elastase-mediated killing of bacteria: lessons from targeted mutagenesis.
Microbes and infection / Institut Pasteur 2002;4(12):1259-64.
2002: Joseph P Gaut; Jaeman Byun; Hung D Tran; Wendy M Lauber; James A Carroll; Richard S Hotchkiss; Azzaq Belaaouaj; Jay W Heinecke
Myeloperoxidase produces nitrating oxidants in vivo.
The Journal of clinical investigation 2002;109(10):1311-9.
2001: Joseph P Gaut; G C Yeh; Hung D Tran; Jaeman Byun; Jeffrey P Henderson; G M Richter; M L Brennan; A J Lusis; Azzaq Belaaouaj; R S Hotchkiss; Jay W Heinecke
Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(21):11961-6.
2000: Azzaq Belaaouaj; A Li; T C Wun; H G Welgus; S D Shapiro
Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.
The Journal of biological chemistry 2000;275(35):27123-8.
2000: Azzaq Belaaouaj; Kwang S Kim; S D Shapiro
Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase.
Science (New York, N.Y.) 2000;289(5482):1185-8.
1999: DM MacIvor; S D Shapiro; C T Pham; Azzaq Belaaouaj; S N Abraham; Timothy J Ley
Normal neutrophil function in cathepsin G-deficient mice.
Blood 1999;94(12):4282-93.
1999: Azzaq Belaaouaj; Christel Moog-Lutz; Jocelyne Just; A Houzel-Charavel; S D Shapiro; Yvon E Cayre
Genomic organization and chromosomal localization of mouse proteinase 3 (Myeloblastin).
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(3):210-2.
1998: Azzaq Belaaouaj; R McCarthy; M Baumann; Z Gao; Timothy J Ley; S N Abraham; S D Shapiro
Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis.
Nature medicine 1998;4(5):615-8.
1997: Azzaq Belaaouaj; B C Walsh; N A Jenkins; N G Copeland; S D Shapiro
Characterization of the mouse neutrophil elastase gene and localization to chromosome 10.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(1):5-8.
1995: Azzaq Belaaouaj; J Michael Shipley; D K Kobayashi; Drazen Zimonjic; N Popescu; G A Silverman; SD Shapiro
Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression.
The Journal of biological chemistry 1995;270(24):14568-75.
1994: Azzaq Belaaouaj; C Lapoumeroulie; M M Caniça; G Vedel; P Névot; Rajagopal Krishnamoorthy; G Paul
Nucleotide sequences of the genes coding for the TEM-like beta-lactamases IRT-1 and IRT-2 (formerly called TRI-1 and TRI-2).
FEMS microbiology letters 1994;120(1-2):75-80.
1993: Azzaq Belaaouaj; Mohan Kuppuswamy; Jens Birktoft; S Paul Bajaj
Revised cDNA sequence of rabbit tissue factor pathway inhibitor.
Thrombosis research 1993;69(6):547-53.
1992: G Vedel; Azzaq Belaaouaj; L Gilly; Roger Labia; A Philippon; P Névot; G Paul
Clinical isolates of Escherichia coli producing TRI beta-lactamases: novel TEM-enzymes conferring resistance to beta-lactamase inhibitors.
The Journal of antimicrobial chemotherapy 1992;30(4):449-62.