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William Eckelman

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Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.
William Eckelman
Changes: choosing a target?
William Eckelman
Review of new clinical applications of radiometal labeled radiopharmaceuticals.

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All Publications

2013: Genliang Lu; Kevin P Maresca; Craig N Zimmerman; William Eckelman; Shawn M Hillier; John L Joyal; John Babich
Synthesis and SAR of novel Re/99mTc-labeled benzenesulfonamide carbonic anhydrase IX inhibitors for molecular imaging of tumor hypoxia.
Journal of medicinal chemistry 2013;56(2):510-20.
2011: William Eckelman
Changes: choosing a target?
Nuclear medicine and biology 2011;38(6):765-9.
2011: William Eckelman
Review of new clinical applications of radiometal labeled radiopharmaceuticals.
Nuclear medicine and biology 2011;38(5):613-6.
2009: John C Umhau; Weiyin Zhou; Richard E Carson; Stanley I Rapoport; Alla Polozova; James Demar; Nahed Hussein; Abesh K Bhattacharjee; Kaizong Ma; Giuseppe Esposito; Sharon Majchrzak-Hong; Peter Herscovitch; William Eckelman; Karen A Kurdziel; Norman Salem
Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography.
Journal of lipid research 2009;50(7):1259-68.
2009: William Eckelman; Michael R Kilbourn; Chester A Mathis
Specific to nonspecific binding in radiopharmaceutical studies: it's not so simple as it seems!
Nuclear medicine and biology 2009;36(3):235-7.
2009: William Eckelman
Unparalleled contribution of technetium-99m to medicine over 5 decades.
JACC. Cardiovascular imaging 2009;2(3):364-8.
2009: K P Maresca; S M Hillier; F J Femia; D Keith; C Barone; J L Joyal; C N Zimmerman; Alan P Kozikowski; J A Barrett; William Eckelman; John Babich
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer.
Journal of medicinal chemistry 2009;52(2):347-57.
2008: Giuseppe Esposito; Giampiero Giovacchini; Jeih-San Liow; Abesh K Bhattacharjee; Deanna Greenstein; Mark B Schapiro; Mark Hallett; Peter Herscovitch; William Eckelman; Richard E Carson; Stanley I Rapoport
Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(9):1414-21.
2008: William Eckelman; Richard C Reba; Gary J Kelloff
Targeted imaging: an important biomarker for understanding disease progression in the era of personalized medicine.
Drug discovery today 2008;13(17-18):748-59.
2008: William Eckelman; Mauro Bonardi; Wynn A Volkert
True radiotracers: are we approaching theoretical specific activity with Tc-99m and I-123?
Nuclear medicine and biology 2008;35(5):523-7.
2008: Frank J Femia; Kevin P Maresca; Shawn M Hillier; Craig N Zimmerman; John L Joyal; John A Barrett; Aras Omer; Vasken Dilsizian; William Eckelman; John Babich
Synthesis and evaluation of a series of 99mTc(CO)3+ lisinopril complexes for in vivo imaging of angiotensin-converting enzyme expression.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):970-7.
2008: Alicia E Reid; Yu-Shin Ding; William Eckelman; Jean Logan; David Alexoff; Colleen Shea; Youwen Xu; Joanna S Fowler
Comparison of the pharmacokinetics of different analogs of 11C-labeled TZTP for imaging muscarinic M2 receptors with PET.
Nuclear medicine and biology 2008;35(3):287-98.
2008: William Eckelman
Further discussions on choosing the number of animals for an experiment.
Nuclear medicine and biology 2008;35(1):1-2.
2007: William Eckelman; David R Vera
After bench to bedside: the impact of disease progression, commercial opportunities and available instrumentation on clinical outcome.
Nuclear medicine and biology 2007;34(7):727-8.
2007: Joseph D Kalen; Jerry I Hirsch; Karen A Kurdziel; William Eckelman; Dale O Kiesewetter
Automated synthesis of 18F analogue of paclitaxel (PAC): [18F]Paclitaxel (FPAC).
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2007;65(6):696-700.
2007: William Eckelman; John Babich
Synthesis and validation of fatty acid analogs radiolabeled by nonisotopic substitution.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(3 Suppl):S100-9.
2007: Bik-Kee Vuong; Dale O Kiesewetter; Lixin Lang; Ying Ma; William Eckelman; Michael A Channing
An automated one-step one-pot [(18)F]FCWAY synthesis: development and minimization of chemical impurities.
Nuclear medicine and biology 2007;34(4):433-8.
2007: Aras Omer; Steven A Messina; Jamshid Shirani; William Eckelman; Vasken Dilsizian
The role and regulation of cardiac angiotensin-converting enzyme for noninvasive molecular imaging in heart failure.
Current cardiology reports 2007;9(2):150-8.
2007: William Eckelman; Michael R Kilbourn; John L Joyal; Renée Labiris; John F Valliant
Justifying the number of animals for each experiment.
Nuclear medicine and biology 2007;34(3):229-32.
2007: Ken-Ichiro Matsumoto; Lawrence P Szajek; Murali K Cherukuri; John A Cook; Jurgen Seidel; Kelly Grimes; Joann Carson; Anastasia L Sowers; Sean English; Michael V Green; Stephen L Bacharach; William Eckelman; James B Mitchell
The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography.
International journal of oncology 2007;30(4):873-81.
2007: Giuseppe Esposito; Giampiero Giovacchini; Margaret Der; Jeih-San Liow; Abesh Kumar Bhattacharjee; Kaizong Ma; Peter Herscovitch; Michael A Channing; William Eckelman; Mark Hallett; Richard E Carson; Stanley I Rapoport
Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography.
NeuroImage 2007;34(4):1342-51.
2007: William R Hendee; Filip Banovac; Paul Langford Carson; Ralph DeFronzo; William Eckelman; Gary D Fullerton; Steven M Larson; Gordon McLennan; Michael J Welch
Biomedical imaging research opportunities workshop IV: a white paper.
Medical physics 2007;34(2):673-9.
2007: Dale O Kiesewetter; Elaine M Jagoda; Kazuaki Shimoji; Ying Ma; William Eckelman
Evaluation of [18F]fluoroxanomeline {5-{4-[(6-[18F]fluorohexyl)oxy]-1,2,5-thiadiazol-3-yl}-1-methyl-1,2,3,6-tetrahydropyridine} in muscarinic knockout mice.
Nuclear medicine and biology 2007;34(2):141-52.
2007: Vasken Dilsizian; William Eckelman; Maria L Loredo; Elaine M Jagoda; Jamshid Shirani
Evidence for tissue angiotensin-converting enzyme in explanted hearts of ischemic cardiomyopathy using targeted radiotracer technique.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2007;48(2):182-7.
2007: Joji Tokugawa; Laura Ravasi; Toshiyuki Nakayama; Lixin Lang; Kathleen C Schmidt; Jurgen Seidel; Michael V Green; Louis Sokoloff; William Eckelman
Distribution of the 5-HT(1A) receptor antagonist [ (18)F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia.
European journal of nuclear medicine and molecular imaging 2007;34(2):259-66.
2007: Jamshid Shirani; Jagat Narula; William Eckelman; Navneet Narula; Vasken Dilsizian
Early imaging in heart failure: exploring novel molecular targets.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2007;14(1):100-10.
2007: William Eckelman; Paola A Erba; Markus Schwaiger; Henry N Wagner; Roger Alberto; Ulderico Mazzi
Postmeeting summary on the round table discussion at the Seventh International Symposium on Technetium in Chemistry and Nuclear Medicine held in Bressanone, Italy on Sept 6-9, 2006.
Nuclear medicine and biology 2007;34(1):1-4.
2006: Ying Ma; Lixin Lang; Dale O Kiesewetter; Elaine M Jagoda; William Eckelman
Species differences in metabolites of PET ligands: serotonergic 5-HT1A receptor antagonists 3-trans-FCWAY and 3-cis-FCWAY.
Nuclear medicine and biology 2006;33(8):1013-9.
2006: James L Tatum; Gary J Kelloff; Robert J Gillies; Jeffrey M Arbeit; J Martin Brown; K.S. Chao; J Donald Chapman; William Eckelman; Anthony W Fyles; Amato J Giaccia; Richard P Hill; Cameron J Koch; Murali K Cherukuri; Kenneth A Krohn; Jason S Lewis; Ralph P Mason; Giovanni Melillo; Anwar R Padhani; Garth Powis; Joseph G Rajendran; Richard Reba; Simon P Robinson; Gregg L Semenza; Harold M Swartz; Peter Vaupel; David Yang; Barbara Croft; John Hoffman; Guoying Liu; Helen Stone; Daniel Sullivan
Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.
International journal of radiation biology 2006;82(10):699-757.
2006: William Eckelman; Michael R Kilbourn; Chester A Mathis
Radiopharmaceutical space.
Nuclear medicine and biology 2006;33(7):829.
2006: Krystof S Bankiewicz; John R Forsayeth; Jamie L Eberling; Rosario Sanchez-Pernaute; Phillip Pivirotto; John Bringas; Peter Herscovitch; Richard E Carson; William Eckelman; Bryan Reutter; Janet Cunningham
Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(4):564-70.
2006: Dara M Cannon; Richard E Carson; Allison Nugent; William Eckelman; Dale O Kiesewetter; Joan Williams; Denise Rollis; Michele Drevets; Shilpa Gandhi; Gerardo Solorio; Wayne C Drevets
Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder.
Archives of general psychiatry 2006;63(7):741-7.
2006: Lixin Lang; Elaine M Jagoda; Ying Ma; Mark B Sassaman; William Eckelman
Synthesis and in vivo biodistribution of F-18 labeled 3-cis-, 3-trans-, 4-cis-, and 4-trans-fluorocyclohexane derivatives of WAY 100635.
Bioorganic & medicinal chemistry 2006;14(11):3737-48.
2006: William Eckelman; Michael R Kilbourn; Chester A Mathis
Discussion of targeting proteins in vivo: in vitro guidelines.
Nuclear medicine and biology 2006;33(4):449-51.
2006: Shelly James; Kevin P Maresca; Damian G Allis; John F Valliant; William Eckelman; John Babich; Jon Zubieta
Extension of the single amino acid chelate concept (SAAC) to bifunctional biotin analogues for complexation of the M(CO)3(+1) Core (M = Tc and Re): syntheses, characterization, biotinidase stability, and avidin binding.
Bioconjugate chemistry 2006;17(3):579-89.
2006: Elaine M Jagoda; Lixin Lang; Joji Tokugawa; Ashlie Simmons; Ying Ma; Carlo Contoreggi; Dale O Kiesewetter; William Eckelman
Development of 5-HT1A receptor radioligands to determine receptor density and changes in endogenous 5-HT.
Synapse (New York, N.Y.) 2006;59(6):330-41.
2006: Jamshid Shirani; Jagat Narula; William Eckelman; Vasken Dilsizian
Novel imaging strategies for predicting remodeling and evolution of heart failure: targeting the Renin-Angiotensin system.
Heart failure clinics 2006;2(2):231-47.
2006: Laura Ravasi; Dale O Kiesewetter; Kazuaki Shimoji; giovanni lucignani; William Eckelman
Why does the agonist [(18)F]FP-TZTP bind preferentially to the M(2) muscarinic receptor?
European journal of nuclear medicine and molecular imaging 2006;33(3):292-300.
2006: William Eckelman; Chester A Mathis
Targeting proteins in vivo: in vitro guidelines.
Nuclear medicine and biology 2006;33(2):161-4.
2006: William Eckelman
Imaging of muscarinic receptors in the central nervous system.
Current pharmaceutical design 2006;12(30):3901-13.
2006: Moustapha E Moustapha; Gary J Ehrhardt; Charles J Smith; Lawrence P Szajek; William Eckelman; Silvia S Jurisson
Preparation of cyclotron-produced 186Re and comparison with reactor-produced 186Re and generator-produced 188Re for the labeling of bombesin.
Nuclear medicine and biology 2006;33(1):81-9.
2006: William Eckelman; Chester A Mathis
Molecular targets.
Nuclear medicine and biology 2006;33(1):1.
2005: Gary J Kelloff; Kenneth A Krohn; Steven M Larson; Ralph Weissleder; David A Mankoff; John M Hoffman; Jeanne M Link; Kathryn Z Guyton; William Eckelman; Howard I Scher; Joyce A O'Shaughnessy; Bruce D Cheson; Caroline C Sigman; James L Tatum; George Q Mills; Daniel C Sullivan; Janet Woodcock
The progress and promise of molecular imaging probes in oncologic drug development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):7967-85.
2005: Steve Y Cho; Laura Ravasi; Lawrence P Szajek; Jurgen Seidel; Michael V Green; Howard A Fine; William Eckelman
Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(11):1923-30.
2005: Giampiero Giovacchini; Lixin Lang; Ying Ma; Peter Herscovitch; William Eckelman; Richard E Carson
Differential effects of paroxetine on raphe and cortical 5-HT1A binding: a PET study in monkeys.
NeuroImage 2005;28(1):238-48.
2005: Paul O Scheibe; David R Vera; William Eckelman
What is to be gained by imaging the same animal before and after treatment?
Nuclear medicine and biology 2005;32(7):727-32.
2005: William Eckelman; Shashank Rohatagi; Kenneth A Krohn; David R Vera
Are there lessons to be learned from drug development that will accelerate the use of molecular imaging probes in the clinic?
Nuclear medicine and biology 2005;32(7):657-62.
2005: Jamshid Shirani; Maria L Loredo; William Eckelman; Elaine M Jagoda; Vasken Dilsizian
Imaging the renin-angiotensin- aldosterone system in the heart.
Current heart failure reports 2005;2(2):78-86.
2005: Giampiero Giovacchini; Maria T Toczek; Robert Bonwetsch; Anto Bagic; Lixin Lang; Charles Fraser; Pat Reeves-Tyer; Peter Herscovitch; William Eckelman; Richard E Carson; William H Theodore
5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(7):1128-35.
2005: Carolyn Beebe Smith; Kathleen C Schmidt; Mei Qin; Thomas V Burlin; Michelle P Cook; Julia Kang; Richard C Saunders; John D Bacher; Richard E Carson; Michael A Channing; William Eckelman; Peter Herscovitch; Peter Laverman; Bik-Kee Vuong
Measurement of regional rates of cerebral protein synthesis with L-[1-11C]leucine and PET with correction for recycling of tissue amino acids: II. Validation in rhesus monkeys.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(5):629-40.
2005: Lihui Wei; John Babich; William Eckelman; Jon Zubieta
Rhenium tricarbonyl core complexes of thymidine and uridine derivatives.
Inorganic chemistry 2005;44(7):2198-209.
2005: Omer Bonne; Earle E Bain; Alexander Neumeister; Allison Nugent; Meena Vythilingam; Richard E Carson; David Luckenbaugh; William Eckelman; Peter Herscovitch; Wayne C Drevets; Dennis S Charney
No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder.
The American journal of psychiatry 2005;162(2):383-5.
2004: Vladimir S Talanov; Alexander T Yordanov; Kayhan Garmestani; Diane E Milenic; Hans C Arora; Paul S Plascjak; William Eckelman; Thomas Waldmann; Martin W Brechbiel
Preparation and in vivo evaluation of novel linkers for 211At labeling of proteins.
Nuclear medicine and biology 2004;31(8):1061-71.
2004: Giampiero Giovacchini; Alicja Lerner; Maria T Toczek; Charles Fraser; Kaizong Ma; James C DeMar; Peter Herscovitch; William Eckelman; Stanley I Rapoport; Richard E Carson
Brain incorporation of 11C-arachidonic acid, blood volume, and blood flow in healthy aging: a study with partial-volume correction.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(9):1471-9.
2004: Elaine M Jagoda; Juan José Vaquero; Jurgen Seidel; Michael V Green; William Eckelman
Experiment assessment of mass effects in the rat: implications for small animal PET imaging.
Nuclear medicine and biology 2004;31(6):771-9.
2004: Brenda E Benson; Richard E Carson; Dale O Kiesewetter; Peter Herscovitch; William Eckelman; Robert M Post; Terence A Ketter
A potential cholinergic mechanism of procaine's limbic activation.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(7):1239-50.
2004: William Eckelman; Kenner C Rice; Carlo Contoreggi
New tools to monitor stress using non-invasive PET imaging.
Annals of the New York Academy of Sciences 2004;1018():487-94.
2004: Zhengsheng Yao; Meili Zhang; Kayhan Garmestani; Axworthy Don; Robert W Mallett; Alan R Fritzberg; Louis J Theodore; Paul S Plascjak; William Eckelman; Thomas Waldmann; Ira Pastan; Chang H Paik; Martin W Brechbiel; Jorge Carrasquillo
Pretargeted alpha emitting radioimmunotherapy using (213)Bi 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-biotin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3137-46.
2004: Ying Ma; Lixin Lang; Dale O Kiesewetter; Bik-Kee Vuong; Michael A Channing; Yoichiro Ito; William Eckelman
Purification of the precursor for the automated radiosynthesis of [18F]FCWAY by counter-current chromatography.
Journal of chromatography. A 2004;1034(1-2):149-53.
2004: Kazuaki Shimoji; Laura Ravasi; Kathleen Schmidt; Maria Luisa Soto-Montenegro; Takanori Esaki; Jurgen Seidel; Elaine M Jagoda; Louis Sokoloff; Michael V Green; William Eckelman
Measurement of cerebral glucose metabolic rates in the anesthetized rat by dynamic scanning with 18F-FDG, the ATLAS small animal PET scanner, and arterial blood sampling.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(4):665-72.
2004: Jon N Wesley; Edwin C McGee; Kayhan Garmestani; Martin W Brechbiel; Alexander T Yordanov; Chuanchu Wu; Otto A Gansow; William Eckelman; John Bacher; Michael Flynn; Carolyn K Goldman; Melvin MacLin; Uwe P Schwartz; Terri Jackson-White; Celeste M Phillip; Jean Decker; Thomas Waldmann
Systemic radioimmunotherapy using a monoclonal antibody, anti-Tac directed toward the alpha subunit of the IL-2 receptor armed with the alpha-emitting radionuclides (212)Bi or (211)At.
Nuclear medicine and biology 2004;31(3):357-64.
2004: Luke S Park; Lawrence P Szajek; Karen J Wong; Paul S Plascjak; Kayhan Garmestani; Shawn Googins; William Eckelman; Jorge Carrasquillo; Chang H Paik
Semi-automated 86Y purification using a three-column system.
Nuclear medicine and biology 2004;31(2):297-301.
2004: Alexander Neumeister; Earle E Bain; Allison Nugent; Richard E Carson; Omer Bonne; David Luckenbaugh; William Eckelman; Peter Herscovitch; Dennis S Charney; Wayne C Drevets
Reduced serotonin type 1A receptor binding in panic disorder.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(3):589-91.
2003: William Eckelman
The use of gene-manipulated mice in the validation of receptor binding radiotracer.
Nuclear medicine and biology 2003;30(8):851-60.
2003: William Eckelman; David R Vera
From bench to bedside.
Nuclear medicine and biology 2003;30(8):793-4.
2003: Ying Ma; Dale O Kiesewetter; Lixin Lang; William Eckelman
Application of LC-MS to the analysis of new radiopharmaceuticals.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2003;5(6):397-403.
2003: Kazuaki Shimoji; Takanori Esaki; Yoshiaki Itoh; Laura Ravasi; Michelle Cook; Jane Jehle; Elaine M Jagoda; Dale O Kiesewetter; Kathleen Schmidt; Louis Sokoloff; William Eckelman
Inhibition of [18F]FP-TZTP binding by loading doses of muscarinic agonists P-TZTP or FP-TZTP in vivo is not due to agonist-induced reduction in cerebral blood flow.
Synapse (New York, N.Y.) 2003;50(2):151-63.
2003: Bill X Huang; Michael A Channing; Paul S Plascjak; Dale O Kiesewetter; Margaret Der; Ying Ma; William Eckelman
Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography.
Nuclear medicine and biology 2003;30(7):785-90.
2003: Robert M Cohen; Teresa A Podruchny; Arun Bokde; Richard E Carson; Peter Herscovitch; Dale O Kiesewetter; William Eckelman; Trey Sunderland
Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele.
Synapse (New York, N.Y.) 2003;49(3):150-6.
2003: Elaine M Jagoda; Carlo Contoreggi; Mei-Jing Lee; Chih-Hao K Kao; Lawrence P Szajek; Samuel J Listwak; Philip Gold; George Chrousos; Elisabeth Greiner; B Moon Kim; Arthur E Jacobson; Kenner C Rice; William Eckelman
Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand: synthesis of [(76)Br]MJL-1-109-2.
Journal of medicinal chemistry 2003;46(17):3559-62.
2003: Karen A Kurdziel; Dale O Kiesewetter; Richard E Carson; William Eckelman; Peter Herscovitch
Biodistribution, radiation dose estimates, and in vivo Pgp modulation studies of 18F-paclitaxel in nonhuman primates.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2003;44(8):1330-9.
2003: William Eckelman
The use of PET and knockout mice in the drug discovery process.
Drug discovery today 2003;8(9):404-10.
2003: Ying Ma; Dale O Kiesewetter; Lixin Lang; Margaret Der; Bill Huang; Richard E Carson; William Eckelman
Determination of [18F]FCWAY, [18F]FP-TZTP, and their metabolites in plasma using rapid and efficient liquid-liquid and solid phase extractions.
Nuclear medicine and biology 2003;30(3):233-40.
2003: Elaine M Jagoda; Dale O Kiesewetter; Kazuaki Shimoji; Laura Ravasi; M Yamada; J Gomeza; J Wess; William Eckelman
Regional brain uptake of the muscarinic ligand, [18F]FP-TZTP, is greatly decreased in M2 receptor knockout mice but not in M1, M3 and M4 receptor knockout mice.
Neuropharmacology 2003;44(5):653-61.
2003: Teresa A Podruchny; Catherine Connolly; Arun Bokde; Peter Herscovitch; William Eckelman; Dale O Kiesewetter; Trey Sunderland; Richard E Carson; Robert M Cohen
In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers.
Synapse (New York, N.Y.) 2003;48(1):39-44.
2003: Maria T Toczek; Richard E Carson; Lixin Lang; Ying Ma; Marianna Spanaki; Margaret Der; S Fazilat; Leonid Kopylev; Peter Herscovitch; William Eckelman; William H Theodore
PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy.
Neurology 2003;60(5):749-56.
2003: Richard E Carson; Yanjun Wu; Lixin Lang; Ying Ma; Margaret Der; Peter Herscovitch; William Eckelman
Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(2):249-60.
2003: Dale O Kiesewetter; Elaine M Jagoda; Chih-Hao K Kao; Ying Ma; Laura Ravasi; Kazuaki Shimoji; Lawrence P Szajek; William Eckelman
Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation.
Nuclear medicine and biology 2003;30(1):11-24.
2002: Giampiero Giovacchini; Michael C J Chang; Michael A Channing; Maria T Toczek; Alicja Mason; Arun Bokde; Catherine Connolly; Bik-Kee Vuong; Ying Ma; Margaret Der; Doris J Doudet; Peter Herscovitch; William Eckelman; Stanley I Rapoport; Richard E Carson
Brain incorporation of [11C]arachidonic acid in young healthy humans measured with positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(12):1453-62.
2002: Ying Ma; Lixin Lang; Dale O Kiesewetter; William Eckelman
Liquid chromatography-tandem mass spectrometry identification of metabolites of three phenylcarboxyl derivatives of the 5-HT(1A) antagonist, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridyl) trans-4-fluorocyclohexanecarboxamide (FCWAY), produced by human and rat hepatocytes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;780(1):99-110.
2002: William Eckelman
Accelerating drug discovery and development through in vivo imaging.
Nuclear medicine and biology 2002;29(8):777-82.
2002: Elaine M Jagoda; Luigi Aloj; Jurgen Seidel; Lixin Lang; Terry W Moody; Shielah Green; Corradina Caraco; Margaret Daube-Witherspoon; Michael V Green; William Eckelman
Comparison of an 18F labeled derivative of vasoactive intestinal peptide and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice bearing breast cancer xenografts.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 2002;4(5):369-79.
2002: Adriana Zingone; J Seidel; Luigi Aloj; Corradina Caraco; Juan José Vaquero; Elaine M Jagoda; Janice Yang Chou; Michael V Green; William Eckelman
Monitoring the correction of glycogen storage disease type 1a in a mouse model using [(18)F]FDG and a dedicated animal scanner.
Life sciences 2002;71(11):1293-301.
2002: Chih-Hao K Kao; Atsuo Waki; Mark B Sassaman; Elaine M Jagoda; Lawrence P Szajek; Laura Ravasi; Kazuaki Shimoji; William Eckelman
Evaluation of [76Br]FBAU 3',5'-dibenzoate as a lipophilic prodrug for brain imaging.
Nuclear medicine and biology 2002;29(5):527-35.
2002: Stephen J Kennel; Saed Mirzadeh; William Eckelman; Thomas Waldmann; Kayhan Garmestani; Alexander T Yordanov; Michael G Stabin; Martin W Brechbiel
Vascular-targeted radioimmunotherapy with the alpha-particle emitter 211At.
Radiation research 2002;157(6):633-41.
2002: William Eckelman; Joseph A Frank; Martin W Brechbiel
Theory and practice of imaging saturable binding sites.
Investigative radiology 2002;37(3):101-6.
2002: Edit B Olasz; Lixin Lang; Jurgen Seidel; Michael V Green; William Eckelman; Stephen I Katz
Fluorine-18 labeled mouse bone marrow-derived dendritic cells can be detected in vivo by high resolution projection imaging.
Journal of immunological methods 2002;260(1-2):137-48.
2002: Ying Ma; Dale O Kiesewetter; Elaine M Jagoda; Bill X Huang; William Eckelman
Identification of metabolites of fluorine-18-labeled M2 muscarinic receptor agonist, 3-(3-[(3-fluoropropyl)thio]-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine, produced by human and rat hepatocytes.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;766(2):319-29.
2002: Ying Ma; Bill X Huang; Michael A Channing; William Eckelman
Quantification of Kryptofix 2.2.2 in 2-[(18)F]FDG and other radiopharmaceuticals by LC/MS/MS.
Nuclear medicine and biology 2002;29(1):125-9.
2002: Dale O Kiesewetter; Elaine M Jagoda; John E Starrett; Valentin K Gribkoff; Piyasena Hewawasam; Nugahally Srinivas; Daniel Salazar; William Eckelman
Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.
Nuclear medicine and biology 2002;29(1):55-9.
2002: Ling-Wei Hsin; Xinrong Tian; Elizabeth Webster; Andrew Coop; Timothy M Caldwell; Arthur E Jacobson; George Chrousos; Philip W Gold; Kamal E Habib; Alejandro Ayala; William Eckelman; Carlo Contoreggi; Kenner C Rice
CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists.
Bioorganic & medicinal chemistry 2002;10(1):175-83.
2001: Steven Libutti; H Richard Alexander; Peter Choyke; David L Bartlett; Stephen L Bacharach; Millie Whatley; F Jousse; William Eckelman; Karen Kranda; Ronald D Neumann; Jorge Carrasquillo
A prospective study of 2-[18F] fluoro-2-deoxy-D-glucose/positron emission tomography scan, 99mTc-labeled arcitumomab (CEA-scan), and blind second-look laparotomy for detecting colon cancer recurrence in patients with increasing carcinoembryonic antigen levels.
Annals of surgical oncology 2001;8(10):779-86.
2001: Zhengsheng Yao; Kayhan Garmestani; Karen J Wong; Luke S Park; Ekaterina Dadachova; Alexander T Yordanov; Thomas Waldmann; William Eckelman; Chang H Paik; Jorge Carrasquillo
Comparative cellular catabolism and retention of astatine-, bismuth-, and lead-radiolabeled internalizing monoclonal antibody.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(10):1538-44.
2001: Alexander T Yordanov; Kayhan Garmestani; Meili Zhang; Zhuo Zhang; Zhengsheng Yao; K E Phillips; B Herring; EM Horak; Markus Beitzel; U P Schwarz; Otto A Gansow; Paul S Plascjak; William Eckelman; Thomas Waldmann; Martin W Brechbiel
Preparation and in vivo evaluation of linkers for 211At labeling of humanized anti-Tac.
Nuclear medicine and biology 2001;28(7):845-56.
2001: William Eckelman
Radiolabeled muscarinic radioligands for in vivo studies.
Nuclear medicine and biology 2001;28(5):485-91.
2001: D R Vera; William Eckelman
Receptor 1980 and Receptor 2000: twenty years of progress in receptor-binding radiotracers.
Nuclear medicine and biology 2001;28(5):475-6.
2001: William Eckelman; R Waterhouse; R Frank
Nuclear imaging and biomarkers in drug development using approved radiopharmaceuticals.
Journal of clinical pharmacology 2001;Suppl():4S-6S.
2001: Ying Ma; Lixin Lang; Dale O Kiesewetter; Elaine M Jagoda; Mark B Sassaman; Margaret Der; William Eckelman
Liquid chromatography-tandem mass spectrometry identification of metabolites of two 5-HT1A antagonists, N-[2-[4-(2-methoxylphenyl)piperazino]ethyl]-N-(2-pyridyl) trans- and cis-4-fluorocyclohexanecarboxamide, produced by human and rat hepatocytes.
Journal of chromatography. B, Biomedical sciences and applications 2001;755(1-2):47-56.
2001: Michael A Channing; Bill X Huang; William Eckelman
Analysis of residual solvents in 2-[(18)F]FDG by GC.
Nuclear medicine and biology 2001;28(4):469-71.
2001: Michael V Green; Jurgen Seidel; Juan José Vaquero; Elaine M Jagoda; I Lee; William Eckelman
High resolution PET, SPECT and projection imaging in small animals.
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society 2001;25(2):79-86.
2001: Xinrong Tian; Ling-Wei Hsin; Elizabeth Webster; Carlo Contoreggi; George Chrousos; Philip W Gold; Kamal E Habib; Alejandro Ayala; William Eckelman; Arthur E Jacobson; Kenner C Rice
The development of a potential single photon emission computed tomography (SPECT) imaging agent for the corticotropin-releasing hormone receptor type.
Bioorganic & medicinal chemistry letters 2001;11(3):331-3.
2001: M F Smith; Margaret Daube-Witherspoon; Paul S Plascjak; Lawrence P Szajek; Richard E Carson; J R Everett; S L Green; Paul R Territo; Robert Balaban; Stephen L Bacharach; William Eckelman
Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies.
Medical physics 2001;28(1):36-45.
2001: Brian E Zimmerman; G J Kubicek; Jeffrey T Cessna; Paul S Plascjak; William Eckelman
Radioassays and experimental evaluation of dose calibrator settings for 18F.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2001;54(1):113-22.
2000: Mitchel A Kling; Richard E Carson; Lisa Borg; Alan J Zametkin; John A Matochik; James H Schluger; Peter Herscovitch; Kenner C Rice; Ann Ho; William Eckelman; Mary Jeanne Kreek
Opioid receptor imaging with positron emission tomography and [(18)F]cyclofoxy in long-term, methadone-treated former heroin addicts.
The Journal of pharmacology and experimental therapeutics 2000;295(3):1070-6.
2000: William Eckelman; J L Tatum; Karen A Kurdziel; B Y Croft
Quantitative analysis of tumor biochemisty using PET and SPECT.
Nuclear medicine and biology 2000;27(7):633-5.
2000: F G Blankenberg; William Eckelman; Harry W Strauss; M J Welch; A Alavi; C Anderson; S Bacharach; Ronald Blasberg; M M Graham; W Weber
Role of radionuclide imaging in trials of antiangiogenic therapy.
Academic radiology 2000;7(10):851-67.
2000: Richard E Carson; Lixin Lang; Hiroshi Watabe; Margaret Der; HR Adams; Elaine M Jagoda; Peter Herscovitch; William Eckelman
PET evaluation of [(18)F]FCWAY, an analog of the 5-HT(1A) receptor antagonist, WAY-100635.
Nuclear medicine and biology 2000;27(5):493-7.
2000: Lixin Lang; Elaine M Jagoda; B Schmall; Mark B Sassaman; Ying Ma; William Eckelman
Fluoro analogs of WAY-100635 with varying pharmacokinetics properties.
Nuclear medicine and biology 2000;27(5):457-62.
2000: Corradina Caracó; Luigi Aloj; Li-Yuan Chen; Janice Yang Chou; William Eckelman
Cellular release of [18F]2-fluoro-2-deoxyglucose as a function of the glucose-6-phosphatase enzyme system.
The Journal of biological chemistry 2000;275(24):18489-94.
2000: Hiroshi Watabe; Michael A Channing; Margaret Der; HR Adams; Elaine M Jagoda; Peter Herscovitch; William Eckelman; Richard E Carson
Kinetic analysis of the 5-HT2A ligand [11C]MDL 100,907.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(6):899-909.
2000: Ling-Wei Hsin; Elizabeth Webster; George Chrousos; Philip W Gold; William Eckelman; Carlo Contoreggi; Kenner C Rice
Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: the development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor.
Bioorganic & medicinal chemistry letters 2000;10(8):707-10.
2000: H Watabe; Christopher J Endres; Alan Breier; B Schmall; William Eckelman; Richard E Carson
Measurement of dopamine release with continuous infusion of [11C]raclopride: optimization and signal-to-noise considerations.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2000;41(3):522-30.
2000: Y Magata; Lixin Lang; Dale O Kiesewetter; Elaine M Jagoda; Michael A Channing; William Eckelman
Biologically stable [(18)F]-labeled benzylfluoride derivatives.
Nuclear medicine and biology 2000;27(2):163-8.
2000: Susan E Shoaf; Richard E Carson; Daniel W Hommer; Wendol A Williams; J Dee Higley; B Schmall; Peter Herscovitch; William Eckelman; Markku Linnoila
The suitability of [11C]-alpha-methyl-L-tryptophan as a tracer for serotonin synthesis: studies with dual administration of [11C] and [14C] labeled tracer.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(2):244-52.
1999: Luigi Aloj; Corradina Caracó; Elaine M Jagoda; William Eckelman; Ronald D Neumann
Glut-1 and hexokinase expression: relationship with 2-fluoro-2-deoxy-D-glucose uptake in A431 and T47D cells in culture.
Cancer research 1999;59(18):4709-14.
1999: Luigi Aloj; E Jogoda; Lixin Lang; Corradina Caracò; Ronald D Neumann; Cynthia Sung; William Eckelman
Targeting of transferrin receptors in nude mice bearing A431 and LS174T xenografts with [18F]holo-transferrin: permeability and receptor dependence.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(9):1547-55.
1999: Lixin Lang; Elaine M Jagoda; B Schmall; Bik-Kee Vuong; HR Adams; D L Nelson; Richard E Carson; William Eckelman
Development of fluorine-18-labeled 5-HT1A antagonists.
Journal of medicinal chemistry 1999;42(9):1576-86.
1999: Dale O Kiesewetter; Richard E Carson; Elaine M Jagoda; Peter Herscovitch; William Eckelman
Using single photon emission tomography (SPECT) and positron emission tomography (PET) to trace the distribution of muscarinic acetylcholine receptor (MACHR) binding radioligands.
Life sciences 1999;64(6-7):511-8.
1999: Dale O Kiesewetter; Richard E Carson; Elaine M Jagoda; Peter Herscovitch; William Eckelman
In vivo muscarinic binding of 3-(alkylthio)-3-thiadiazolyl tetrahydropyridines.
Synapse (New York, N.Y.) 1999;31(1):29-40.
1998: Terry W Moody; Julius Leyton; Illana Gozes; L Lang; William Eckelman
VIP and breast cancer.
Annals of the New York Academy of Sciences 1998;865():290-6.
1998: Corradina Caraco; Luigi Aloj; William Eckelman
The gallium-deferoxamine complex: stability with different deferoxamine concentrations and incubation conditions.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1998;49(12):1477-9.
1998: Susan E Shoaf; R Carson; Daniel W Hommer; Wendol Williams; J Dee Higley; B Schmall; Peter Herscovitch; William Eckelman; Markku Linnoila
Brain serotonin synthesis rates in rhesus monkeys determined by [11C]alpha-methyl-L-tryptophan and positron emission tomography compared to CSF 5-hydroxyindole-3-acetic acid concentrations.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1998;19(5):345-53.
1998: Mark B Sassaman; J Giovanelli; V K Sood; William Eckelman
Synthesis and screening of conformationally restricted and conformationally free N-(tertiary aminoalkyl)dithiocarbamic acids and esters as inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 1998;6(10):1759-66.
1998: Richard E Carson; Dale O Kiesewetter; Elaine M Jagoda; Margaret Der; Peter Herscovitch; William Eckelman
Muscarinic cholinergic receptor measurements with [18F]FP-TZTP: control and competition studies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(10):1130-42.
1998: Jorge Carrasquillo; L Lang; Millie Whatley; P Herscovitch; Qing-Cheng Wang; Ira Pastan; William Eckelman
Aminosyn II effectively blocks renal uptake of 18F-labeled anti-tac disulfide-stabilized Fv.
Cancer research 1998;58(12):2612-7.
1998: William Eckelman
Sensitivity of new radiopharmaceuticals.
Nuclear medicine and biology 1998;25(3):169-73.
1998: U P Schwarz; Paul S Plascjak; Markus Beitzel; Otto A Gansow; William Eckelman; Thomas Waldmann
Preparation of 211At-labeled humanized anti-Tac using 211At produced in disposable internal and external bismuth targets.
Nuclear medicine and biology 1998;25(2):89-93.
1998: Terry W Moody; Julius Leyton; Edward Joseph Unsworth; C John; L Lang; William Eckelman
(Arg15, Arg21) VIP: evaluation of biological activity and localization to breast cancer tumors.
Peptides 1998;19(3):585-92.
1997: Christopher J Endres; Bhaskar S Kolachana; Richard C Saunders; T Su; Daniel R Weinberger; Alan Breier; William Eckelman; Richard E Carson
Kinetic modeling of [11C]raclopride: combined PET-microdialysis studies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(9):932-42.
1997: Dale O Kiesewetter; Richard E Carson; Elaine M Jagoda; Christopher J Endres; Margaret Der; Peter Herscovitch; William Eckelman
In vivo muscarinic binding selectivity of (R,S)- and (R,R)-[18F]-fluoromethyl QNB.
Bioorganic & medicinal chemistry 1997;5(8):1555-67.
1997: Lixin Lang; Elaine M Jagoda; Chuanchu Wu; Martin W Brechbiel; Otto A Gansow; Ira Pastan; Chang H Paik; Jorge Carrasquillo; William Eckelman
Factors influencing the in vivo pharmacokinetics of peptides and antibody fragments: the pharmacokinetics of two PET-labeled low molecular weight proteins.
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR) 1997;41(2):53-61.
1997: Chuanchu Wu; E Jagoda; Martin W Brechbiel; KO Webber; Ira Pastan; Otto A Gansow; William Eckelman
Biodistribution and catabolism of Ga-67-labeled anti-Tac dsFv fragment.
Bioconjugate chemistry 1997;8(3):365-9.
1997: Michael C J Chang; T Arai; L M Freed; S Wakabayashi; Michael A Channing; B B Dunn; Margaret Der; Jane M Bell; T Sasaki; P Herscovitch; William Eckelman; Stanley I Rapoport
Brain incorporation of [1-11C]arachidonate in normocapnic and hypercapnic monkeys, measured with positron emission tomography.
Brain research 1997;755(1):74-83.
1997: Richard E Carson; Alan Breier; Andrea de Bartolomeis; Richard C Saunders; TP Su; B Schmall; Margaret Der; DAVID PICKAR; William Eckelman
Quantification of amphetamine-induced changes in [11C]raclopride binding with continuous infusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(4):437-47.
1997: Luigi Aloj; Richard E Carson; Lixin Lang; Peter Herscovitch; William Eckelman
Measurement of transferrin receptor kinetics in the baboon liver using dynamic positron emission tomography imaging and [18F]holo-transferrin.
Hepatology (Baltimore, Md.) 1997;25(4):986-90.
1997: Alan Breier; TP Su; R Saunders; Richard E Carson; Bhaskar S Kolachana; Andrea de Bartolomeis; Daniel R Weinberger; NI Weisenfeld; Anil Malhotra; William Eckelman; DAVID PICKAR
Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: evidence from a novel positron emission tomography method.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2569-74.
1997: Paul S Plascjak; K Kim; W Meyer; J Divel; Margaret Der; William Eckelman
An automated radiopharmaceutical dispenser.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1997;48(3):345-8.
1997: Lixin Lang; William Eckelman
Labeling proteins at high specific activity using N-succinimidyl 4-[18F](fluoromethyl) benzoate.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1997;48(2):169-73.
1997: Tae M Yoo; H K Chang; C W Choi; KO Webber; Nhat Le; IS Kim; William Eckelman; Ira Pastan; Jorge Carrasquillo; Chang H Paik
Technetium-99m labeling and biodistribution of anti-TAC disulfide-stabilized Fv fragment.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1997;38(2):294-300.
1997: OH Kapp; J Siemion; William Eckelman; VI Cohen; Richard C Reba
Molecular modeling of the interaction of diagnostic radiopharmaceuticals with receptor proteins: m2 antagonist binding to the muscarinic m2 subtype receptor.
Receptors & signal transduction 1997;7(3):177-201.
1996: SF Boulay; VK Sood; M R Rayeq; BR Zeeberg; William Eckelman
Autoradiographic evidence that (R)-3-quinuclidinyl (S)-4-fluoromethylbenzilate ((R,S)-FMeQNB) displays in vivo selectivity for the muscarinic m2 subtype.
Nuclear medicine and biology 1996;23(7):889-96.
1996: Hisataka Kobayashi; Tae M Yoo; IS Kim; Meyoung-Kon Kim; Nhat Le; KO Webber; Ira Pastan; Chang H Paik; William Eckelman; Jorge Carrasquillo
L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.
Cancer research 1996;56(16):3788-95.
1996: Lixin Lang; Luigi Aloj; Dale O Kiesewetter; Elaine M Jagoda; J T Lee; Chang H Paik; Jorge Carrasquillo; William Eckelman
A review of new oncotropic tracers for PET imaging.
Nuclear medicine and biology 1996;23(6):669-72.
1996: Luigi Aloj; Lixin Lang; Elaine M Jagoda; Ronald D Neumann; William Eckelman
Evaluation of human transferrin radiolabeled with N-succinimidyl 4-[fluorine-18](fluoromethyl) benzoate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1996;37(8):1408-12.
1996: K Kawai; H Ohta; A Kubodera; M A Channing; William Eckelman
Synthesis and evaluation of radioiodinated 6-iodo-L-DOPA as a cerebral L-amino acid transport marker.
Nuclear medicine and biology 1996;23(3):251-5.
1996: K Kawai; H Ohta; M A Channing; A Kubodera; William Eckelman
Synthesis of polymer-bound 6-mercuric carboxylate DOPA precursors and solid phase labelling method of 6-radioiodinated L-DOPA.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1996;47(1):37-44.
1995: T Arai; S Wakabayashi; M A Channing; B B Dunn; Margaret Der; Jane M Bell; Peter Herscovitch; William Eckelman; Stanley I Rapoport; Michael C J Chang
Incorporation of [1-carbon-11]palmitate in monkey brain using PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(12):2261-7.
1995: William Eckelman
Positron emission tomography: radiochemistry.
Academic radiology 1995;2 Suppl 2():S96-7.
1995: Stanley Baum; William Eckelman; E V Garcia; B L Holman; H F Kung; R F Mattrey; D Piwnica-Worms; Richard L Wahl; J T Watson
Contrast media and radiopharmaceutical agents: regulatory issues.
Academic radiology 1995;2 Suppl 2():S92-3.
1995: J Lee; Chang H Paik; Dale O Kiesewetter; S G Park; William Eckelman
Evaluation of stereoisomers of 4-fluoroalkyl analogues of 3-quinuclidinyl benzilate in in vivo competition studies for the M1, M2, and M3 muscarinic receptor subtypes in brain.
Nuclear medicine and biology 1995;22(6):773-81.
1995: William Eckelman
Designing a molecular probe for muscarinic acetylcholine receptor (mAChR) imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(6 Suppl):5S-7S.
1995: Y Hiramatsu; William Eckelman; Jorge Carrasquillo; R S Miletich; I H Valdez; R H Kurrasch; A A Macynski; Chang H Paik; R D Neumann; Bruce J Baum
Kinetic analysis of muscarinic receptors in human brain and salivary gland in vivo.
The American journal of physiology 1995;268(6 Pt 2):R1491-9.
1995: Dale O Kiesewetter; J V Silverton; William Eckelman
Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates.
Journal of medicinal chemistry 1995;38(10):1711-9.
1995: S S Jurisson; J Pirro; R J DiRocco; K C Rosenspire; E Jagoda; P Nanjappan; William Eckelman; David Nowotnik; Adrian Nunn
Boronic acid adducts of technetium dioxime (BATO) complexes derived from quinuclidine benzilate (QNB) boronic acid stereoisomers: syntheses and studies of their binding to the muscarinic acetylcholine receptor.
Nuclear medicine and biology 1995;22(3):269-81.
1995: William Eckelman
Radiolabeling with technetium-99m to study high-capacity and low-capacity biochemical systems.
European journal of nuclear medicine 1995;22(3):249-63.
1995: Dale O Kiesewetter; J Lee; Lixin Lang; S G Park; Chang H Paik; William Eckelman
Preparation of 18F-labeled muscarinic agonist with M2 selectivity.
Journal of medicinal chemistry 1995;38(1):5-8.
1995: K Kawai; M A Channing; Dale O Kiesewetter; William Eckelman
Synthesis of polymer-bound 6-thiolatomercury and 6-mercuric sulfonate DOPA precursors and their halodemercuration reactivity.
Nuclear medicine and biology 1995;22(1):37-43.
1994: Lixin Lang; William Eckelman
One-step synthesis of 18F labeled [18F]-N-succinimidyl 4-(fluoromethyl)benzoate for protein labeling.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 1994;45(12):1155-63.
1994: William Eckelman
The application of receptor theory to receptor-binding and enzyme-binding oncologic radiopharmaceuticals.
Nuclear medicine and biology 1994;21(5):759-69.
1994: Y Hiramatsu; William Eckelman; Bruce J Baum
Interaction of iodinated quinuclidinyl benzilate enantiomers with M3 muscarinic receptors.
Life sciences 1994;54(23):1777-83.
1993: Karen Linder; Y W Chan; J E Cyr; David Nowotnik; William Eckelman; Adrian Nunn
Synthesis, characterization, and in vitro evaluation of nitroimidazole--BATO complexes: new technetium compounds designed for imaging hypoxic tissue.
Bioconjugate chemistry 1993;4(5):326-33.
1993: S M Eaton; PW Wedeking; Michael Tweedle; William Eckelman
A multi-organ, axially distributed model of capillary permeability for a magnetic resonance imaging contrast agent.
Journal of pharmaceutical sciences 1993;82(5):531-6.
1993: R J Di Rocco; D A Silva; B L Kuczynski; R K Narra; K Ramalingam; S Jurisson; Adrian Nunn; William Eckelman
The single-pass cerebral extraction and capillary permeability-surface area product of several putative cerebral blood flow imaging agents.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1993;34(4):641-8.
1993: RC Stadalnik; M Kudo; William Eckelman; David R Vera
In vivo functional imaging using receptor-binding radiopharmaceuticals. Technetium 99m-galactosyl-neoglycoalbumin as a model.
Investigative radiology 1993;28(1):64-70.
1992: K C Rosenspire; W Hirth; S Jurisson; David Nowotnik; William Eckelman; Adrian Nunn
Direct analysis of whole blood by internal surface reversed-phase chromatography: an examination of the binding and metabolism of technetium dioxime complexes.
Journal of chromatography 1992;574(1):119-26.
1991: Karen Linder; M D Wen; David Nowotnik; K Ramalingam; R M Sharkey; F Yost; R K Narra; Adrian Nunn; William Eckelman
Technetium labeling of monoclonal antibodies with functionalized BATOs: 2. TcCl(DMG)3CPITC labeling of B72.3 and NP-4 whole antibodies and NP-4 F(ab')2.
Bioconjugate chemistry 1991;2(6):407-14.
1991: D R Hwang; William Eckelman; C J Mathias; E W Petrillo; J Lloyd; Michael J Welch
Positron-labeled angiotensin-converting enzyme (ACE) inhibitor: fluorine-18-fluorocaptopril. Probing the ACE activity in vivo by positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1991;32(9):1730-7.
1991: Karen Linder; M D Wen; David Nowotnik; M F Malley; J Z Gougoutas; Adrian Nunn; William Eckelman
Technetium labeling of monoclonal antibodies with functionalized BATOs. 1. TcCl(DMG)3PITC.
Bioconjugate chemistry 1991;2(3):160-70.
1991: William Eckelman; J Steigman
Direct labeling with 99mTc.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(1):3-7.
1991: William Eckelman
The status of radiopharmaceutical research.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1991;18(7):iii-vi.
1990: Y Sawada; S Hiraga; B Francis; C Patlak; K Pettigrew; K Ito; E Owens; R Gibson; R Reba; William Eckelman
Kinetic analysis of 3-quinuclidinyl 4-[125I]iodobenzilate transport and specific binding to muscarinic acetylcholine receptor in rat brain in vivo: implications for human studies.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(6):781-807.
1990: R K Narra; Adrian Nunn; B L Kuczynski; R J DiRocco; T Feld; D A Silva; William Eckelman
A neutral lipophilic technetium-99m complex for regional cerebral blood flow imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1990;31(8):1370-7.
1990: J I Tu; J Brennan; B Stouffer; William Eckelman
A radioimmunoassay for SQ 27,519, the active phosphinic acid-carboxylic diacid of the prodrug fosinopril in human serum.
Therapeutic drug monitoring 1990;12(4):404-10.
1990: William Eckelman
Development of radiochemically pure antibodies.
Cancer research 1990;50(3 Suppl):780s-782s.
1990: PW Wedeking; S Eaton; D G Covell; S Nair; Michael Tweedle; William Eckelman
Pharmacokinetic analysis of blood distribution of intravenously administered 153Gd-labeled Gd(DTPA)2- and 99mTc(DTPA) in rats.
Magnetic resonance imaging 1990;8(5):567-75.
1989: R K Narra; Adrian Nunn; B L Kuczynski; T Feld; PW Wedeking; William Eckelman
A neutral technetium-99m complex for myocardial imaging.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(11):1830-7.
1989: Raymond E Gibson; T A Schneidau; V I Cohen; VK Sood; J Ruch; J Melograna; William Eckelman; Richard C Reba
In vitro and in vivo characteristics of [iodine-125] 3-(R)-quinuclidinyl (S)-4-iodobenzilate.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1989;30(6):1079-87.
1989: William Eckelman
Diagnostic isotopes. Prospects for improved agents.
Investigative radiology 1989;24(3):252-4.
1989: William Eckelman; C H Paik; J Steigman
Three approaches to radiolabeling antibodies with 99mTc.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989;16(2):171-6.
1989: William Eckelman
The use of in vitro models to predict the distribution of receptor binding radiotracers in vivo.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1989;16(3):233-45.
1988: Michael Tweedle; S M Eaton; William Eckelman; G T Gaughan; J J Hagan; PW Wedeking; F J Yost
Comparative chemical structure and pharmacokinetics of MRI contrast agents.
Investigative radiology 1988;23 Suppl 1():S236-9.
1988: William Eckelman
Radiopharmaceuticals for tomographic imaging of the brain.
American journal of physiologic imaging 1988;3(1):66.
1987: M E McManaway; E M Jagoda; A Kasid; William Eckelman; B E Francis; Steven M Larson; R E Gibson; R C Reba; Marc Lippman
[125I]17-alpha-iodovinyl 11-beta-methoxyestradiol interaction in vivo with estrogen receptors in hormone-independent MCF-7 human breast cancer transfected with the v-rasH oncogene.
Cancer research 1987;47(11):2945-9.
1986: M E McManaway; E M Jagoda; William Eckelman; Steven M Larson; B E Francis; R E Gibson; R C Reba; Marc Lippman
Binding characteristics and biological activity of 17 alpha-[125I]iodovinyl-11 beta-methoxyestradiol, an estrogen receptor-binding radiopharmaceutical, in human breast cancer cells (MCF-7).
Cancer research 1986;46(5):2386-9.
1986: C H Paik; William Eckelman; R C Reba
Transchelation of 99mTc from low affinity sites to high affinity sites of antibody.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(4):359-62.
1986: William Eckelman; C H Paik
Comparison of 99mTc and 111In labeling of conjugated antibodies.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(4):335-43.
1986: Dale O Kiesewetter; William Eckelman; Robert M Cohen; R D Finn; Steven M Larson
Syntheses and D2 receptor affinities of derivatives of spiperone containing aliphatic halogens.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1986;37(12):1181-8.
1986: William Eckelman
Receptors labeled with gamma-emitting radiotracers.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology 1986;13(2):135-9.
1985: B L Holman; R E Gibson; T C Hill; William Eckelman; Marilyn S Albert; R C Reba
Muscarinic acetylcholine receptors in Alzheimer's disease. In vivo imaging with iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate and emission tomography.
JAMA : the journal of the American Medical Association 1985;254(21):3063-6.
1985: William Eckelman; R Eng; W J Rzeszotarski; Raymond E Gibson; B Francis; Richard C Reba
Use of 3-quinuclidinyl 4-iodobenzilate as a receptor binding radiotracer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1985;26(6):637-42.
1985: M A Channing; William Eckelman; J M Bennett; T R Burke; K C Rice
Radiosynthesis of [18F]3-acetylcyclofoxy: a high affinity opiate antagonist.
The International journal of applied radiation and isotopes 1985;36(6):429-33.
1985: C H Paik; J J Hong; M A Ebbert; S C Heald; R C Reba; William Eckelman
Relative reactivity of DTPA, immunoreactive antibody-DTPA conjugates, and nonimmunoreactive antibody-DTPA conjugates toward indium-111.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1985;26(5):482-7.
1985: C H Paik; L N Phan; J J Hong; M S Sahami; S C Heald; R C Reba; J Steigman; William Eckelman
The labeling of high affinity sites of antibodies with 99mTc.
International journal of nuclear medicine and biology 1985;12(1):3-8.
1985: Raymond E Gibson; William Eckelman; Richard C Reba; E M Jagoda; W J Rzeszotarski; M Grissom; J Conklin; R Eng
Receptor-selective localization in pancreas.
International journal of nuclear medicine and biology 1985;12(1):29-32.
1984: C B Pert; J A Danks; M A Channing; William Eckelman; Steven M Larson; J M Bennett; T R Burke; K C Rice
3-[18F]Acetylcyclofoxy: a useful probe for the visualization of opiate receptors in living animals.
FEBS letters 1984;177(2):281-6.
1984: I Nakatsuka; N L Ferreira; William Eckelman; B E Francis; W J Rzeszotarski; Raymond E Gibson; E M Jagoda; Richard C Reba
Synthesis and evaluation of (17 alpha,20E)-21-[125I]iodo-19-norpregna-1,3,5(10),20-tetraene-3,17 -diol and (17 alpha,20E)-21-[125I]iodo-11 beta-methoxy-19-norpregna-1,3,5(10),20-tetraene-3,17-diol (17 alpha-(iodovinyl)estradiol derivatives) as high specific activity potential radiopharmaceuticals.
Journal of medicinal chemistry 1984;27(10):1287-91.
1984: Raymond E Gibson; W J Rzeszotarski; E M Jagoda; B E Francis; Richard C Reba; William Eckelman
[125I] 3-quinuclidinyl 4-iodobenzilate: a high affinity, high specific activity radioligand for the M1 and M2-acetylcholine receptors.
Life sciences 1984;34(23):2287-96.
1984: William Eckelman; R E Gibson
Re: Receptor binding of F-18 haloperidol and spiroperidol.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1984;25(4):532-6.