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Michael Hutton

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
O'Farrell C A; Martin K L; Hutton M; Delatycki M B; Cookson M R; Lockhart P J
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
Adams Stephanie J; Crook Richard J P; Deture Michael; Randle Suzanne J; Innes Amy E; Yu Xin Z; Lin Wen-Lang; Dugger Brittany N; McBride Melinda; Hutton Mike; Dickson Dennis W; McGowan Eileen
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration.
Pereson Sandra; Wils Hans; Kleinberger Gernot; McGowan Eileen; Vandewoestyne Mado; Van Broeck Bianca; Joris Geert; Cuijt Ivy; Deforce Dieter; Hutton Michael; Van Broeckhoven Christine; Kumar-Singh Samir
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.

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All Publications

2009: O'Farrell C A; Martin K L; Hutton M; Delatycki M B; Cookson M R; Lockhart P J
Mutant torsinA interacts with tyrosine hydroxylase in cultured cells.
Neuroscience 2009;164(3):1127-37.
2009: Adams Stephanie J; Crook Richard J P; Deture Michael; Randle Suzanne J; Innes Amy E; Yu Xin Z; Lin Wen-Lang; Dugger Brittany N; McBride Melinda; Hutton Mike; Dickson Dennis W; McGowan Eileen
Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration.
The American journal of pathology 2009;175(4):1598-609.
2009: Pereson Sandra; Wils Hans; Kleinberger Gernot; McGowan Eileen; Vandewoestyne Mado; Van Broeck Bianca; Joris Geert; Cuijt Ivy; Deforce Dieter; Hutton Michael; Van Broeckhoven Christine; Kumar-Singh Samir
Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
The Journal of pathology 2009;219(2):173-81.
2009: Kelley Brendan J; Haidar Wael; Boeve Bradley F; Baker Matt; Graff-Radford Neill R; Krefft Thomas; Frank Andrew R; Jack Clifford R; Shiung Maria; Knopman David S; Josephs Keith A; Parashos Sotirios A; Rademakers Rosa; Hutton Mike; Pickering-Brown Stuart; Adamson Jennifer; Kuntz Karen M; Dickson Dennis W; Parisi Joseph E; Smith Glenn E; Ivnik Robert J; Petersen Ronald C
Prominent phenotypic variability associated with mutations in Progranulin.
Neurobiology of aging 2009;30(5):739-51.
2009: Tatom Jason B; Wang David B; Dayton Robert D; Skalli Omar; Hutton Michael L; Dickson Dennis W; Klein Ronald L
Mimicking aspects of frontotemporal lobar degeneration and Lou Gehrig's disease in rats via TDP-43 overexpression.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(4):607-13.
2008: Morgan Dave; Munireddy Sanjay; Alamed Jennifer; DeLeon Jason; Diamond David M; Bickford Paula; Hutton Michael; Lewis Jada; McGowan Eileen; Gordon Marcia N
Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice.
Journal of Alzheimer's disease : JAD 2008;15(4):605-14.
2008: Rademakers Rosa; Eriksen Jason L; Baker Matt; Robinson Todd; Ahmed Zeshan; Lincoln Sarah J; Finch Nicole; Rutherford Nicola J; Crook Richard J; Josephs Keith A; Boeve Bradley F; Knopman David S; Petersen Ronald C; Parisi Joseph E; Caselli Richard J; Wszolek Zbigniew K; Uitti Ryan J; Feldman Howard; Hutton Michael L; Mackenzie Ian R; Graff-Radford Neill R; Dickson Dennis W
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.
Human molecular genetics 2008;17(23):3631-42.
2008: Sando Sigrid Botne; Melquist Stacey; Cannon Ashley; Hutton Michael; Sletvold Olav; Saltvedt Ingvild; White Linda R; Lydersen Stian; Aasly Jan
Risk-reducing effect of education in Alzheimer's disease.
International journal of geriatric psychiatry 2008;23(11):1156-62.
2008: Rudzinski Leslie A; Fletcher Rita M; Dickson Dennis W; Crook Richard; Hutton Michael L; Adamson Jennifer; Graff-Radford Neill R
Early onset familial Alzheimer Disease with spastic paraparesis, dysarthria, and seizures and N135S mutation in PSEN1.
Alzheimer disease and associated disorders 2008;22(3):299-307.
2008: Coppola Giovanni; Karydas Anna; Rademakers Rosa; Wang Qing; Baker Matt; Hutton Mike; Miller Bruce L; Geschwind Daniel H
Gene expression study on peripheral blood identifies progranulin mutations.
Annals of neurology 2008;64(1):92-6.
2008: Vega Irving E; Traverso Edwin E; Ferrer-Acosta Yancy; Matos Eduardo; Colon Migdalisel; Gonzalez John; Dickson Dennis; Hutton Michael; Lewis Jada; Yen Shu H
A novel calcium-binding protein is associated with tau proteins in tauopathy.
Journal of neurochemistry 2008;106(1):96-106.
2008: Wider Christian; Uitti Ryan J; Wszolek Zbigniew K; Fang John Y; Josephs Keith A; Baker Matthew C; Rademakers Rosa; Hutton Michael L; Dickson Dennis W
Progranulin gene mutation with an unusual clinical and neuropathologic presentation.
Movement disorders : official journal of the Movement Disorder Society 2008;23(8):1168-73.
2008: Boeve Bradley F; Hutton Mike
Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN).
Archives of neurology 2008;65(4):460-4.
2008: Wider C; Melquist S; Hauf M; Solida A; Cobb S A; Kachergus J M; Gass J; Coon K D; Baker M; Cannon A; Stephan D A; Schorderet D F; Ghika J; Burkhard P R; Kapatos G; Hutton M; Farrer M J; Wszolek Z K; Vingerhoets F J G
Study of a Swiss dopa-responsive dystonia family with a deletion in GCH1: redefining DYT14 as DYT5.
Neurology 2008;70(16 Pt 2):1377-83.
2008: Ertekin-Taner N; Younkin L H; Yager D M; Parfitt F; Baker M C; Asthana S; Hutton M L; Younkin S G; Graff-Radford N R
Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families.
Neurology 2008;70(8):596-606.
2008: Rutherford Nicola J; Zhang Yong-Jie; Baker Matt; Gass Jennifer M; Finch Nicole A; Xu Ya-Fei; Stewart Heather; Kelley Brendan J; Kuntz Karen; Crook Richard J P; Sreedharan Jemeen; Vance Caroline; Sorenson Eric; Lippa Carol; Bigio Eileen H; Geschwind Daniel H; Knopman David S; Mitsumoto Hiroshi; Petersen Ronald C; Cashman Neil R; Hutton Mike; Shaw Christopher E; Boylan Kevin B; Boeve Bradley; Graff-Radford Neill R; Wszolek Zbigniew K; Caselli Richard J; Dickson Dennis W; Mackenzie Ian R; Petrucelli Leonard; Rademakers Rosa
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.
PLoS genetics 2008;4(9):e1000193.
2008: Pickering-Brown Stuart; Hutton Michael
The genetics of frontotemporal dementia.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2008;89():383-92.
2008: Sando Sigrid B; Melquist Stacey; Cannon Ashley; Hutton Michael L; Sletvold Olav; Saltvedt Ingvild; White Linda R; Lydersen Stian; Aasly Jan O
APOE epsilon 4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case control study from central Norway.
BMC neurology 2008;8():9.
2007: Goldman Jill S; Adamson Jennifer; Karydas Anna; Miller Bruce L; Hutton Mike
New genes, new dilemmas: FTLD genetics and its implications for families.
American journal of Alzheimer's disease and other dementias 2007;22(6):507-15.
2007: Bolmont Tristan; Clavaguera Florence; Meyer-Luehmann Melanie; Herzig Martin C; Radde Rebecca; Staufenbiel Matthias; Lewis Jada; Hutton Mike; Tolnay Markus; Jucker Mathias
Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice.
The American journal of pathology 2007;171(6):2012-20.
2007: Hu William T; Mandrekar Jayawant N; Parisi Joseph E; Knopman David S; Boeve Bradley F; Petersen Ronald C; Hutton Michael; Dickson Dennis W; Josephs Keith A
Clinical features of pathologic subtypes of behavioral--variant frontotemporal dementia.
Archives of neurology 2007;64(11):1611-6.
2007: Seabrook Guy R; Ray William J; Shearman Mark; Hutton Michael
Beyond amyloid: the next generation of Alzheimer's disease therapeutics.
Molecular interventions 2007;7(5):261-70.
2007: Rademakers Rosa; Baker Matt; Gass Jennifer; Adamson Jennifer; Huey Edward D; Momeni Parastoo; Spina Salvatore; Coppola Giovanni; Karydas Anna M; Stewart Heather; Johnson Nancy; Hsiung Ging-Yuek; Kelley Brendan; Kuntz Karen; Steinbart Ellen; Wood Elisabeth McCarty; Yu Chang-En; Josephs Keith; Sorenson Eric; Womack Kyle B; Weintraub Sandra; Pickering-Brown Stuart M; Schofield Peter R; Brooks William S; Van Deerlin Vivianna M; Snowden Julie; Clark Christopher M; Kertesz Andrew; Boylan Kevin; Ghetti Bernardino; Neary David; Schellenberg Gerard D; Beach Thomas G; Mesulam Marsel; Mann David; Grafman Jordan; Mackenzie Ian R; Feldman Howard; Bird Thomas; Petersen Ron; Knopman David; Boeve Bradley; Geschwind Dan H; Miller Bruce; Wszolek Zbigniew; Lippa Carol; Bigio Eileen H; Dickson Dennis; Graff-Radford Neill; Hutton Mike
Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative.
Lancet neurology 2007;6(10):857-68.
2007: Caselli Richard J; Reiman Eric M; Locke Dona E C; Hutton Michael L; Hentz Joseph G; Hoffman-Snyder Charlene; Woodruff Bryan K; Alexander Gene E; Osborne David
Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.
Archives of neurology 2007;64(9):1306-11.
2007: Rademakers Rosa; Hutton Mike
The genetics of frontotemporal lobar degeneration.
Current neurology and neuroscience reports 2007;7(5):434-42.
2007: Davion S; Johnson N; Weintraub S; Mesulam M-M; Engberg A; Mishra M; Baker M; Adamson J; Hutton M; Rademakers R; Bigio E H
Clinicopathologic correlation in PGRN mutations.
Neurology 2007;69(11):1113-21.
2007: Dunckley Travis; Huentelman Matthew J; Craig David W; Pearson John V; Szelinger Szabolcs; Joshipura Keta; Halperin Rebecca F; Stamper Chelsea; Jensen Kendall R; Letizia David; Hesterlee Sharon E; Pestronk Alan; Levine Todd; Bertorini Tulio; Graves Michael C; Mozaffar Tahseen; Jackson Carlayne E; Bosch Peter; McVey April; Dick Arthur; Barohn Richard; Lomen-Hoerth Catherine; Rosenfeld Jeffrey; O'connor Daniel T; Zhang Kuixing; Crook Richard; Ryberg Henrik; Hutton Michael; Katz Jonathan; Simpson Ericka P; Mitsumoto Hiroshi; Bowser Robert; Miller Robert G; Appel Stanley H; Stephan Dietrich A
Whole-genome analysis of sporadic amyotrophic lateral sclerosis.
The New England journal of medicine 2007;357(8):775-88.
2007: Haugarvoll Kristoffer; Wszolek Zbigniew K; Hutton Michael
The genetics of frontotemporal dementia.
Neurologic clinics 2007;25(3):697-715, vi.
2007: Schymick J C; Yang Y; Andersen P M; Vonsattel J P; Greenway M; Momeni P; Elder J; Chiò A; Restagno G; Robberecht W; Dahlberg C; Mukherjee O; Goate A; Graff-Radford N; Caselli R J; Hutton M; Gass J; Cannon A; Rademakers R; Singleton A B; Hardiman O; Rothstein J; Hardy J; Traynor B J
Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes.
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):754-6.
2007: Baba Y; Baker M C; Le Ber I; Brice A; Maeck L; Kohlhase J; Yasuda M; Stoppe G; Bugiani O; Sperfeld A D; Tsuboi Y; Uitti R J; Farrer M J; Ghetti B; Hutton M L; Wszolek Z K
Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation.
Journal of neural transmission (Vienna, Austria : 1996) 2007;114(7):947-50.
2007: Reiman Eric M; Webster Jennifer A; Myers Amanda J; Hardy John; Dunckley Travis; Zismann Victoria L; Joshipura Keta D; Pearson John V; Hu-Lince Diane; Huentelman Matthew J; Craig David W; Coon Keith D; Liang Winnie S; Herbert RiLee H; Beach Thomas; Rohrer Kristen C; Zhao Alice S; Leung Doris; Bryden Leslie; Marlowe Lauren; Kaleem Mona; Mastroeni Diego; Grover Andrew; Heward Christopher B; Ravid Rivka; Rogers Joseph; Hutton Michael L; Melquist Stacey; Petersen Ron C; Alexander Gene E; Caselli Richard J; Kukull Walter; Papassotiropoulos Andreas; Stephan Dietrich A
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Neuron 2007;54(5):713-20.
2007: Amador-Ortiz Catalina; Lin Wen-Lang; Ahmed Zeshan; Personett David; Davies Peter; Duara Ranjan; Graff-Radford Neill R; Hutton Michael L; Dickson Dennis W
TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease.
Annals of neurology 2007;61(5):435-45.
2007: Arvanitakis Zoe; Witte Robert J; Dickson Dennis W; Tsuboi Yoshio; Uitti Ryan J; Slowinski Jerzy; Hutton Michael L; Lin Siong-Chi; Boeve Bradley F; Cheshire William P; Pooley Robert A; Liss Julie M; Caviness John N; Strongosky Audrey J; Wszolek Zbigniew K
Clinical-pathologic study of biomarkers in FTDP-17 (PPND family with N279K tau mutation).
Parkinsonism & related disorders 2007;13(4):230-9.
2007: Dächsel Justus C; Ross Owen A; Mata Ignacio F; Kachergus Jennifer; Toft Mathias; Cannon Ashley; Baker Matt; Adamson Jennifer; Hutton Mike; Dickson Dennis W; Farrer Matthew J
Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions.
Acta neuropathologica 2007;113(5):601-6.
2007: Berger Zdenek; Roder Hanno; Hanna Amanda; Carlson Aaron; Rangachari Vijayaraghavan; Yue Mei; Wszolek Zbigniew; Ashe Karen; Knight Joshua; Dickson Dennis; Andorfer Cathy; Rosenberry Terrone L; Lewis Jada; Hutton Mike; Janus Christopher
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(14):3650-62.
2007: Roder Hanno M; Hutton Michael L
Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.
Expert opinion on therapeutic targets 2007;11(4):435-42.
2007: Melquist Stacey; Craig David W; Huentelman Matthew J; Crook Richard; Pearson John V; Baker Matt; Zismann Victoria L; Gass Jennifer; Adamson Jennifer; Szelinger Szabolcs; Corneveaux Jason; Cannon Ashley; Coon Keith D; Lincoln Sarah; Adler Charles; Tuite Paul; Calne Donald B; Bigio Eileen H; Uitti Ryan J; Wszolek Zbigniew K; Golbe Lawrence I; Caselli Richard J; Graff-Radford Neill; Litvan Irene; Farrer Matthew J; Dickson Dennis W; Hutton Mike; Stephan Dietrich A
Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms.
American journal of human genetics 2007;80(4):769-78.
2007: Whitwell Jennifer L; Jack Clifford R; Baker Matthew; Rademakers Rosa; Adamson Jennifer; Boeve Bradley F; Knopman David S; Parisi Joseph F; Petersen Ronald C; Dickson Dennis W; Hutton Michael L; Josephs Keith A
Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations.
Archives of neurology 2007;64(3):371-6.
2007: Dickey Chad A; Kamal Adeela; Lundgren Karen; Klosak Natalia; Bailey Rachel M; Dunmore Judith; Ash Peter; Shoraka Sareh; Zlatkovic Jelena; Eckman Christopher B; Patterson Cam; Dickson Dennis W; Nahman N Stanley; Hutton Michael; Burrows Francis; Petrucelli Leonard
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.
The Journal of clinical investigation 2007;117(3):648-58.
2007: Josephs Keith A; Ahmed Zeshan; Katsuse Omi; Parisi Joseph F; Boeve Bradley F; Knopman David S; Petersen Ronald C; Davies Peter; Duara Ranjan; Graff-Radford Neill R; Uitti Ryan J; Rademakers Rosa; Adamson Jennifer; Baker Matthew; Hutton Michael L; Dickson Dennis W
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Journal of neuropathology and experimental neurology 2007;66(2):142-51.
2007: Dickson Dennis W; Rademakers Rosa; Hutton Michael L
Progressive supranuclear palsy: pathology and genetics.
Brain pathology (Zurich, Switzerland) 2007;17(1):74-82.
2007: Mehta Sarju G; Watts Giles D J; Adamson Jennifer L; Hutton Mike; Umberger Geanie; Xiong Shuling; Ramdeen Sheena; Lovell Mark A; Kimonis Virginia E; Smith Charles D
APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD).
Genetics in medicine : official journal of the American College of Medical Genetics 2007;9(1):9-13.
2007: Mesulam Marsel; Johnson Nancy; Krefft Thomas A; Gass Jennifer M; Cannon Ashley D; Adamson Jennifer L; Bigio Eileen H; Weintraub Sandra; Dickson Dennis W; Hutton Michael L; Graff-Radford Neill R
Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families.
Archives of neurology 2007;64(1):43-7.
2007: Pearson John V; Huentelman Matthew J; Halperin Rebecca F; Tembe Waibhav D; Melquist Stacey; Homer Nils; Brun Marcel; Szelinger Szabolcs; Coon Keith D; Zismann Victoria L; Webster Jennifer A; Beach Thomas; Sando Sigrid B; Aasly Jan O; Heun Reinhard; Jessen Frank; Kolsch Heike; Tsolaki Magdalini; Daniilidou Makrina; Reiman Eric M; Papassotiropoulos Andreas; Hutton Michael L; Stephan Dietrich A; Craig David W
Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.
American journal of human genetics 2007;80(1):126-39.
2007: Ahmed Zeshan; Mackenzie Ian R A; Hutton Michael L; Dickson Dennis W
Progranulin in frontotemporal lobar degeneration and neuroinflammation.
Journal of neuroinflammation 2007;4():7.
2006: Golde Todd E; Dickson Dennis; Hutton Michael
Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease.
Current Alzheimer research 2006;3(5):421-30.
2006: Momeni Parastoo; Bell Jason; Duckworth Jaime; Hutton Mike; Mann David; Brown Stuart Pickering; Hardy John
Sequence analysis of all identified open reading frames on the frontal temporal dementia haplotype on chromosome 3 fails to identify unique coding variants except in CHMP2B.
Neuroscience letters 2006;410(2):77-9.
2006: Katsuse Omi; Lin Wen-Lang; Lewis Jada; Hutton Michael L; Dickson Dennis W
Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice.
Neuroscience letters 2006;409(2):95-9.
2006: Pickering-Brown Stuart M; Baker Matt; Gass Jenny; Boeve Bradley F; Loy Clement T; Brooks William S; Mackenzie Ian R A; Martins Ralph N; Kwok John B J; Halliday Glenda M; Kril Jillian; Schofield Peter R; Mann David M A; Hutton Mike
Mutations in progranulin explain atypical phenotypes with variants in MAPT.
Brain : a journal of neurology 2006;129(Pt 11):3124-6.
2006: Mackenzie Ian R A; Baker Matt; Pickering-Brown Stuart; Hsiung Ging-Yuek R; Lindholm Caroline; Dwosh Emily; Gass Jennifer; Cannon Ashley; Rademakers Rosa; Hutton Mike; Feldman Howard H
The neuropathology of frontotemporal lobar degeneration caused by mutations in the progranulin gene.
Brain : a journal of neurology 2006;129(Pt 11):3081-90.
2006: Boeve Bradley F; Baker Matt; Dickson Dennis W; Parisi Joseph E; Giannini Caterina; Josephs Keith A; Hutton Michael; Pickering-Brown Stuart M; Rademakers Rosa; Tang-Wai David; Jack Clifford R; Kantarci Kejal; Shiung Maria M; Golde Todd; Smith Glenn E; Geda Yonas E; Knopman David S; Petersen Ronald C
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Brain : a journal of neurology 2006;129(Pt 11):3103-14.
2006: Gass Jennifer; Cannon Ashley; Mackenzie Ian R; Boeve Bradley; Baker Matt; Adamson Jennifer; Crook Richard; Melquist Stacey; Kuntz Karen; Petersen Ron; Josephs Keith; Pickering-Brown Stuart M; Graff-Radford Neill; Uitti Ryan; Dickson Dennis; Wszolek Zbigniew; Gonzalez John; Beach Thomas G; Bigio Eileen; Johnson Nancy; Weintraub Sandra; Mesulam Marsel; White Charles L; Woodruff Bryan; Caselli Richard; Hsiung Ging-Yuek; Feldman Howard; Knopman Dave; Hutton Mike; Rademakers Rosa
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
Human molecular genetics 2006;15(20):2988-3001.
2006: Huey Edward D; Grafman Jordan; Wassermann Eric M; Pietrini Pietro; Tierney Michael C; Ghetti Bernardino; Spina Salvatore; Baker Matt; Hutton Mike; Elder Joshua W; Berger Stephen L; Heflin Kyle A; Hardy John; Momeni Parastoo
Characteristics of frontotemporal dementia patients with a Progranulin mutation.
Annals of neurology 2006;60(3):374-80.
2006: Wszolek Z K; Baba Y; Mackenzie I R; Uitti R J; Strongosky A J; Broderick D F; Baker M C; Melquist S; Hutton M L; Tsuboi Y; Allanson J E; Carr J; Kumar A; Calne S M; Miklossy J; McGeer P L; Calne D B; Stoessl A J
Autosomal dominant dystonia-plus with cerebral calcifications.
Neurology 2006;67(4):620-5.
2006: Baker Matt; Mackenzie Ian R; Pickering-Brown Stuart M; Gass Jennifer; Rademakers Rosa; Lindholm Caroline; Snowden Julie; Adamson Jennifer; Sadovnick A Dessa; Rollinson Sara; Cannon Ashley; Dwosh Emily; Neary David; Melquist Stacey; Richardson Anna; Dickson Dennis; Berger Zdenek; Eriksen Jason; Robinson Todd; Zehr Cynthia; Dickey Chad A; Crook Richard; McGowan Eileen; Mann David; Boeve Bradley; Feldman Howard; Hutton Mike
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Nature 2006;442(7105):916-9.
2006: Dickey Chad A; Yue Mei; Lin Wen-Lang; Dickson Dennis W; Dunmore Judith H; Lee Wing C; Zehr Cynthia; West Gemma; Cao Songsong; Clark Amber M K; Caldwell Guy A; Caldwell Kim A; Eckman Christopher; Patterson Cam; Hutton Michael; Petrucelli Leonard
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(26):6985-96.
2006: Le Corre Sylvie; Klafki Hans W; Plesnila Nikolaus; Hübinger Gabriele; Obermeier Axel; Sahagún Heidi; Monse Barbara; Seneci Pierfausto; Lewis Jada; Eriksen Jason; Zehr Cynthia; Yue Mei; McGowan Eileen; Dickson Dennis W; Hutton Michael; Roder Hanno M
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(25):9673-8.
2006: McGowan Eileen; Eriksen Jason; Hutton Michael
A decade of modeling Alzheimer's disease in transgenic mice.
Trends in genetics : TIG 2006;22(5):281-9.
2006: Cannon Ashley; Baker Matthew; Boeve Brad; Josephs Keith; Knopman David; Petersen Ron; Parisi Joseph; Dickison Dennis; Adamson Jennifer; Snowden Julie; Neary David; Mann David; Hutton Mike; Pickering-Brown Stuart M
CHMP2B mutations are not a common cause of frontotemporal lobar degeneration.
Neuroscience letters 2006;398(1-2):83-4.
2006: Josephs Keith A; Katsuse Omi; Beccano-Kelly Dayne A; Lin Wen-Lang; Uitti Ryan J; Fujino Yasuhiro; Boeve Bradley F; Hutton Michael L; Baker Matthew C; Dickson Dennis W
Atypical progressive supranuclear palsy with corticospinal tract degeneration.
Journal of neuropathology and experimental neurology 2006;65(4):396-405.
2006: Baba Yasuhiko; Ghetti Bernardino; Baker Matthew C; Uitti Ryan J; Hutton Michael L; Yamaguchi Keiji; Bird Thomas; Lin Wenlang; DeLucia Michael W; Dickson Dennis W; Wszolek Zbigniew K
Hereditary diffuse leukoencephalopathy with spheroids: clinical, pathologic and genetic studies of a new kindred.
Acta neuropathologica 2006;111(4):300-11.
2006: Dickey Chad A; Dunmore Judith; Lu Bingwei; Wang Ji-Wu; Lee Wing C; Kamal Adeela; Burrows Francis; Eckman Christopher; Hutton Michael; Petrucelli Leonard
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(6):753-5.
2006: Mackenzie Ian R; Baker Matthew; West Gemma; Woulfe John; Qadi Najeeb; Gass Jennifer; Cannon Ashley; Adamson Jennifer; Feldman Howard; Lindholm Caroline; Melquist Stacey; Pettman Rachel; Sadovnick A Dessa; Dwosh Emily; Whiteheart Sidney W; Hutton Michael; Pickering-Brown Stuart M
A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17.
Brain : a journal of neurology 2006;129(Pt 4):853-67.
2006: DeTure Michael; Granger Brian; Grover Andrew; Hutton Mike; Yen Shu-Hui
Evidence for independent mechanisms and a multiple-hit model of tau assembly.
Biochemical and biophysical research communications 2006;339(3):858-64.
2006: Momeni Parastoo; Schymick Jennifer; Jain Shushant; Cookson Mark R; Cairns Nigel J; Greggio Elisa; Greenway Matthew J; Berger Stephen; Pickering-Brown Stuart; Chiò Adriano; Fung Hon Chung; Holtzman David M; Huey Edward D; Wassermann Eric M; Adamson Jennifer; Hutton Michael L; Rogaeva Ekaterina; St George-Hyslop Peter; Rothstein Jeffrey D; Hardiman Orla; Grafman Jordan; Singleton Andrew; Hardy John; Traynor Bryan J
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
BMC neurology 2006;6():44.
2006: Dickey Chad A; Ash Peter; Klosak Natalia; Lee Wing C; Petrucelli Leonard; Hutton Michael; Eckman Christopher B
Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.
Molecular neurodegeneration 2006;1():6.
2005: Lin Wen-Lang; Zehr Cindy; Lewis Jada; Hutton Michael; Yen Shu-Hui; Dickson Dennis W
Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau.
Journal of neurocytology 2005;34(6):397-410.
2005: Ramsden Martin; Kotilinek Linda; Forster Colleen; Paulson Jennifer; McGowan Eileen; SantaCruz Karen; Guimaraes Aaron; Yue Mei; Lewis Jada; Carlson George; Hutton Michael; Ashe Karen H
Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L).
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(46):10637-47.
2005: Rademakers Rosa; Melquist Stacey; Cruts Marc; Theuns Jessie; Del-Favero Jurgen; Poorkaj Parvoneh; Baker Matt; Sleegers Kristel; Crook Richard; De Pooter Tim; Bel Kacem Samira; Adamson Jennifer; Van den Bossche Dirk; Van den Broeck Marleen; Gass Jennifer; Corsmit Ellen; De Rijk Peter; Thomas Natalie; Engelborghs Sebastiaan; Heckman Michael; Litvan Irene; Crook Julia; De Deyn Peter P; Dickson Dennis; Schellenberg Gerard D; Van Broeckhoven Christine; Hutton Michael L
High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.
Human molecular genetics 2005;14(21):3281-92.
2005: Rodriguez-Martin Teresa; Garcia-Blanco Mariano A; Mansfield S Gary; Grover Andrew C; Hutton Michael; Yu Qingming; Zhou Jianhua; Anderton Brian H; Gallo Jean-Marc
Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(43):15659-64.
2005: Hardy J; Pittman A; Myers A; Gwinn-Hardy K; Fung H C; de Silva R; Hutton M; Duckworth J
Evidence suggesting that Homo neanderthalensis contributed the H2 MAPT haplotype to Homo sapiens.
Biochemical Society transactions 2005;33(Pt 4):582-5.
2005: Vega Irving E; Cui Li; Propst Josh A; Hutton Michael L; Lee Gloria; Yen Shu-Hui
Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.
Brain research. Molecular brain research 2005;138(2):135-44.
2005: McGowan Eileen; Pickford Fiona; Kim Jungsu; Onstead Luisa; Eriksen Jason; Yu Cindy; Skipper Lisa; Murphy M Paul; Beard Jenny; Das Pritam; Jansen Karen; Delucia Michael; Lin Wen-Lang; Dolios Georgia; Wang Rong; Eckman Christopher B; Dickson Dennis W; Hutton Mike; Hardy John; Golde Todd
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Neuron 2005;47(2):191-9.
2005: Santacruz K; Lewis J; Spires T; Paulson J; Kotilinek L; Ingelsson M; Guimaraes A; DeTure M; Ramsden M; McGowan E; Forster C; Yue M; Orne J; Janus C; Mariash A; Kuskowski M; Hyman B; Hutton M; Ashe K H
Tau suppression in a neurodegenerative mouse model improves memory function.
Science (New York, N.Y.) 2005;309(5733):476-81.
2005: Rippon G A; Boeve B F; Parisi J E; Dickson D W; Ivnik R I; Jack C R; Hutton M; Baker M; Josephs K A; Knopman D S; Petersen R C
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology.
Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology 2005;11(3):204-11.
2005: Baba Yasuhiko; Tsuboi Yoshio; Baker Matthew C; Uitti Ryan J; Hutton Michael L; Dickson Dennis W; Farrer Matthew; Putzke John D; Woodruff Bryan K; Ghetti Bernardino; Murrell Jill R; Boeve Bradley F; Petersen Ronald C; Verpillat Patrice; Brice Alexis; Delisle Marie-Bernadette; Rascol Oliver; Arima Kunimasa; Dysken Maurice W; Yasuda Minoru; Kobayashi Tomonori; Sunohara Nobuhiko; Komure Osamu; Kuno Sadako; Sperfeld Anne D; Stoppe Gabriela; Kohlhase Jürgen; Pickering-Brown Stuart; Neary David; Bugiani Orso; Wszolek Zbigniew K
The effect of tau genotype on clinical features in FTDP-17.
Parkinsonism & related disorders 2005;11(4):205-8.
2005: Baba Yasuhiko; Broderick Daniel F; Uitti Ryan J; Hutton Michael L; Wszolek Zbigniew K
Heredofamilial brain calcinosis syndrome.
Mayo Clinic proceedings. Mayo Clinic 2005;80(5):641-51.
2005: Dickey Chad A; Eriksen Jason; Kamal Adeela; Burrows Francis; Kasibhatla Srinivas; Eckman Christopher B; Hutton Mike; Petrucelli Leonard
Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors.
Current Alzheimer research 2005;2(2):231-8.
2005: Halverson Robyn A; Lewis Jada; Frausto Shanti; Hutton Mike; Muma Nancy A
Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(5):1226-33.
2005: Ertekin-Taner Nilüfer; Ronald James; Feuk Lars; Prince Jonathan; Tucker Michael; Younkin Linda; Hella Maria; Jain Shushant; Hackett Alyssa; Scanlin Leah; Kelly Jason; Kihiko-Ehman Muthoni; Neltner Matthew; Hersh Louis; Kindy Mark; Markesbery William; Hutton Michael; de Andrade Mariza; Petersen Ronald C; Graff-Radford Neill; Estus Steve; Brookes Anthony J; Younkin Steven G
Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.
Human molecular genetics 2005;14(3):447-60.
2004: Oliveira J R M; Spiteri E; Sobrido M J; Hopfer S; Klepper J; Voit T; Gilbert J; Wszolek Z K; Calne D B; Stoessl A J; Hutton M; Manyam B V; Boller F; Baquero M; Geschwind D H
Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease).
Neurology 2004;63(11):2165-7.
2004: Skipper Lisa; Wilkes Kristen; Toft Mathias; Baker Matthew; Lincoln Sarah; Hulihan Mary; Ross Owen A; Hutton Mike; Aasly Jan; Farrer Matthew
Linkage disequilibrium and association of MAPT H1 in Parkinson disease.
American journal of human genetics 2004;75(4):669-77.
2004: Woodruff Bryan K; Baba Yasuhiko; Hutton Michael L; Wszolek Zbigniew K; Tsuboi Yoshio; Kobayashi Tomonori; Ghetti Bernardino; Arima Kunimasa; Yasuda Minoru; Rascol Olivier
Haplotype-phenotype correlations in kindreds with the N279K mutation in the tau gene.
Archives of neurology 2004;61(8):1327; author reply 1327.
2004: Hutton Michael; McGowan Eileen
Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed.
Neuron 2004;43(3):293-4.
2004: Sahara Naruhiko; Vega Irving E; Ishizawa Takashi; Lewis Jada; McGowan Eileen; Hutton Michael; Dickson Dennis; Yen Shu-Hui
Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins.
Journal of neurochemistry 2004;90(4):829-38.
2004: Arendash Gary W; Lewis Jada; Leighty Ralph E; McGowan Eileen; Cracchiolo Jennifer R; Hutton Mike; Garcia Marcos F
Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain.
Brain research 2004;1012(1-2):29-41.
2004: Pickering-Brown S M; Baker M; Nonaka T; Ikeda K; Sharma S; Mackenzie J; Simpson S A; Moore J W; Snowden J S; de Silva R; Revesz T; Hasegawa M; Hutton M; Mann D M A
Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene.
Brain : a journal of neurology 2004;127(Pt 6):1415-26.
2004: Hutton Michael
Presenilin mutations associated with fronto-temporal dementia.
Annals of neurology 2004;55(5):604-6.
2004: Zehr Cindy; Lewis Jada; McGowan Eileen; Crook Julia; Lin Wen-Lang; Godwin Kate; Knight Joshua; Dickson Dennis W; Hutton Mike
Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice.
Neurobiology of disease 2004;15(3):553-62.
2004: Petrucelli Leonard; Dickson Dennis; Kehoe Kathryn; Taylor Julie; Snyder Heather; Grover Andrew; De Lucia Michael; McGowan Eileen; Lewis Jada; Prihar Guy; Kim Jungsu; Dillmann Wolfgang H; Browne Susan E; Hall Alexis; Voellmy Richard; Tsuboi Yoshio; Dawson Ted M; Wolozin Benjamin; Hardy John; Hutton Mike
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation.
Human molecular genetics 2004;13(7):703-14.
2004: Pickering-Brown Stuart; Baker Matt; Bird Thomas; Trojanowski John; Lee Virginia; Morris Huw; Rossor Martin; Janssen John C; Neary David; Craufurd David; Richardson Anna; Snowden Julie; Hardy John; Mann David; Hutton Mike
Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;125B(1):79-82.
2004: Garcia M F; Gordon M N; Hutton M; Lewis J; McGowan E; Dickey C A; Morgan D; Arendash G W
The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice.
Neuroreport 2004;15(1):73-7.
2004: Klein Ronald L; Lin Wen-Lang; Dickson Dennis W; Lewis Jada; Hutton Michael; Duff Karen; Meyer Edwin M; King Michael A
Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau.
The American journal of pathology 2004;164(1):347-53.
2003: Ertekin-Taner Nilüfer; Ronald James; Asahara Hideaki; Younkin Linda; Hella Maria; Jain Shushant; Gnida Eugene; Younkin Samuel; Fadale Daniel; Ohyagi Yasumasa; Singleton Adam; Scanlin Leah; de Andrade Mariza; Petersen Ronald; Graff-Radford Neill; Hutton Michael; Younkin Steven
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Human molecular genetics 2003;12(23):3133-43.
2003: Lin Wen-Lang; Lewis Jada; Yen Shu-Hui; Hutton Michael; Dickson Dennis W
Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.
Journal of neurocytology 2003;32(9):1091-105.
2003: Grover Andrew; England Elisabet; Baker Mathew; Sahara Naruhiko; Adamson Jennifer; Granger Brian; Houlden Henry; Passant Ulla; Yen Shu-Hui; DeTure Michael; Hutton Michael
A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy.
Experimental neurology 2003;184(1):131-40.
2003: Hogg Marion; Grujic Zoran M; Baker Matt; Demirci Serpil; Guillozet Angela L; Sweet Alison P; Herzog Laura L; Weintraub Sandra; Mesulam M-Marsel; LaPointe Nichole E; Gamblin T C; Berry Robert W; Binder Lester I; de Silva Rohan; Lees Andrew; Espinoza Marisol; Davies Peter; Grover Andrew; Sahara Naruhiko; Ishizawa Takashi; Dickson Dennis; Yen Shu-Hui; Hutton Michael; Bigio Eileen H
The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy.
Acta neuropathologica 2003;106(4):323-36.
2003: Ishizawa Takashi; Sahara Narahiko; Ishiguro Koichi; Kersh Jay; McGowan Eileen; Lewis Jada; Hutton Michael; Dickson Dennis W; Yen Shu-Hui
Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice.
The American journal of pathology 2003;163(3):1057-67.
2003: Beach Thomas G; Sue Lucia; Scott Sarah; Layne Kathryn; Newell Amanda; Walker Douglas; Baker Matthew; Sahara Naraju; Yen Shu-Hui; Hutton Michael; Caselli Richard; Adler Charles; Connor Donald; Sabbagh Marwan
Hippocampal sclerosis dementia with tauopathy.
Brain pathology (Zurich, Switzerland) 2003;13(3):263-78.
2003: Rippon Gregory A; Crook Richard; Baker Matthew; Halvorsen Elizabeth; Chin Steven; Hutton Michael; Houlden Henry; Hardy John; Lynch Timothy
Presenilin 1 mutation in an african american family presenting with atypical Alzheimer dementia.
Archives of neurology 2003;60(6):884-8.
2003: Tsuboi Y; Uitti R J; Baker M; Hutton M L; Wszolek Z K
Clinical features of frontotemporal dementia due to the intronic tau 10(+16) mutation.
Neurology 2003;60(3):525-6.
2003: Willis Floyd; Graff-Radford Neill; Pinto Martin; Lawson LaShaune; Adamson Jennifer; Epstein Dawn; Parfitt Francine; Hutton Mike; O'Brien Peter C
Apolipoprotein epsilon4 allele frequency in young Africans of Ugandan descent versus African Americans.
Journal of the National Medical Association 2003;95(1):71-6.
2003: Lin Wen-Lang; Lewis Jada; Yen Shu-Hui; Hutton Michael; Dickson Dennis W
Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation.
The American journal of pathology 2003;162(1):213-8.
2003: Bird Thomas; Knopman David; VanSwieten John; Rosso Sonia; Feldman Howard; Tanabe Hirotaka; Graff-Raford Neil; Geschwind Daniel; Verpillat Patrice; Hutton Michael
Epidemiology and genetics of frontotemporal dementia/Pick's disease.
Annals of neurology 2003;54 Suppl 5():S29-31.
2003: Wszolek Zbigniew K; Tsuboi Yoshio; Farrer Mathew; Uitti Ryan J; Hutton Mike L
Hereditary tauopathies and parkinsonism.
Advances in neurology 2003;91():153-63.
2002: Tsuboi Y; Baker M; Hutton M L; Uitti R J; Rascol O; Delisle M-B; Soulages X; Murrell J R; Ghetti B; Yasuda M; Komure O; Kuno S; Arima K; Sunohara N; Kobayashi T; Mizuno Y; Wszolek Z K
Clinical and genetic studies of families with the tau N279K mutation (FTDP-17).
Neurology 2002;59(11):1791-3.
2002: Walker Ruth H; Friedman Joseph; Wiener Jill; Hobler Ronald; Gwinn-Hardy Katrina; Adam Amanda; DeWolfe Jennifer; Gibbs Rebecca; Baker Matt; Farrer Matt; Hutton Mike; Hardy John
A family with a tau P301L mutation presenting with parkinsonism.
Parkinsonism & related disorders 2002;9(2):121-3.
2002: Sahara Naruhiko; Lewis Jada; DeTure Michael; McGowan Eileen; Dickson Dennis W; Hutton Mike; Yen Shu-Hui
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Journal of neurochemistry 2002;83(6):1498-508.
2002: Morris H R; Baker M; Yasojima K; Houlden H; Khan M N; Wood N W; Hardy J; Grossman M; Trojanowski J; Revesz T; Bigio E H; Bergeron C; Janssen J C; McGeer P L; Rossor M N; Lees A J; Lantos P L; Hutton M
Analysis of tau haplotypes in Pick's disease.
Neurology 2002;59(3):443-5.
2002: Utton Michelle A; Connell James; Asuni Ayodeji A; van Slegtenhorst Marjon; Hutton Michael; de Silva Rohan; Lees Andrew J; Miller Chris C J; Anderton Brian H
The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6394-400.
2002: Togo Takashi; Sahara Naruhiko; Yen Shu-Hui; Cookson Natalie; Ishizawa Takashi; Hutton Mike; de Silva Rohan; Lees Andrew; Dickson Dennis W
Argyrophilic grain disease is a sporadic 4-repeat tauopathy.
Journal of neuropathology and experimental neurology 2002;61(6):547-56.
2002: Tsuboi Yoshio; Uitti Ryan J; Delisle Marie-Bernadette; Ferreira Joaquim J; Brefel-Courbon Christine; Rascol Olivier; Ghetti Bernardino; Murrell Jill R; Hutton Michael; Baker Matthew; Wszolek Zbigniew K
Clinical features and disease haplotypes of individuals with the N279K tau gene mutation: a comparison of the pallidopontonigral degeneration kindred and a French family.
Archives of neurology 2002;59(6):943-50.
2002: Ponting Chris P; Hutton Mike; Nyborg Andrew; Baker Matthew; Jansen Karen; Golde Todd E
Identification of a novel family of presenilin homologues.
Human molecular genetics 2002;11(9):1037-44.
2002: Short Rodney A; Graff-Radford Neill R; Adamson Jennifer; Baker Matt; Hutton Mike
Differences in tau and apolipoprotein E polymorphism frequencies in sporadic frontotemporal lobar degeneration syndromes.
Archives of neurology 2002;59(4):611-5.
2002: Graff-Radford Neill R; Green Robert C; Go Rodney C P; Hutton Michael L; Edeki Timi; Bachman David; Adamson Jennifer L; Griffith Patrick; Willis Floyd B; Williams Mary; Hipps Yvonne; Haines Jonathan L; Cupples L Adrienne; Farrer Lindsay A
Association between apolipoprotein E genotype and Alzheimer disease in African American subjects.
Archives of neurology 2002;59(4):594-600.
2002: Pickering-Brown S M; Richardson A M T; Snowden J S; McDonagh A M; Burns A; Braude W; Baker M; Liu W-K; Yen S-H; Hardy J; Hutton M; Davies Y; Allsop D; Craufurd D; Neary D; Mann D M A
Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene.
Brain : a journal of neurology 2002;125(Pt 4):732-51.
2002: Grover Andrew; DeTure Michael; Yen Shu Hui; Hutton Mike
Effects on splicing and protein function of three mutations in codon N296 of tau in vitro.
Neuroscience letters 2002;323(1):33-6.
2002: Amtul Zareen; Lewis Patrick A; Piper Sian; Crook Richard; Baker Matt; Findlay Kirk; Singleton Andrew; Hogg Marion; Younkin Linda; Younkin Steven G; Hardy John; Hutton Michael; Boeve Bradley F; Tang-Wai David; Golde Todd E
A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.
Neurobiology of disease 2002;9(2):269-73.
2002: Farrer Matt; Hardy John; Hutton Mike; Maraganore Demetrius; Tsuboi Yoshio; Wszolek Zbigniew K
Identifying genetic factors in Parkinson disease.
JAMA : the journal of the American Medical Association 2002;287(6):715-6.
2002: Tang-Wai D; Lewis P; Boeve Bradley; Hutton M; Golde T; Baker M; Hardy J; Michels V; Ivnik R; Jack C; Petersen R
Familial frontotemporal dementia associated with a novel presenilin-1 mutation.
Dementia and geriatric cognitive disorders 2002;14(1):13-21.
2002: Boeve B F; Maraganore D M; Parisi J E; Ivnik R J; Westmoreland B F; Dickson D W; Hutton M; Hardy J; Caselli R J; Petersen R C
Corticobasal degeneration and frontotemporal dementia presentations in a kindred with nonspecific histopathology.
Dementia and geriatric cognitive disorders 2002;13(2):80-90.
2001: Morris H R; Khan M N; Janssen J C; Brown J M; Perez-Tur J; Baker M; Ozansoy M; Hardy J; Hutton M; Wood N W; Lees A J; Revesz T; Lantos P; Rossor M N
The genetic and pathological classification of familial frontotemporal dementia.
Archives of neurology 2001;58(11):1813-6.
2001: Maraganore D M; Hernandez D G; Singleton A B; Farrer M J; McDonnell S K; Hutton M L; Hardy J A; Rocca W A
Case-Control study of the extended tau gene haplotype in Parkinson's disease.
Annals of neurology 2001;50(5):658-61.
2001: Russ C; Powell J F; Zhao J; Baker M; Hutton M; Crawford F; Mullan M; Roks G; Cruts M; Lovestone S
The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis.
Neuroscience letters 2001;314(1-2):92-6.
2001: Liu W K; Le T V; Adamson J; Baker M; Cookson N; Hardy J; Hutton M; Yen S H; Dickson D W
Relationship of the extended tau haplotype to tau biochemistry and neuropathology in progressive supranuclear palsy.
Annals of neurology 2001;50(4):494-502.
2001: Hutton M; Lewis J; Dickson D; Yen S H; McGowan E
Analysis of tauopathies with transgenic mice.
Trends in molecular medicine 2001;7(10):467-70.
2001: Lewis J; Dickson D W; Lin W L; Chisholm L; Corral A; Jones G; Yen S H; Sahara N; Skipper L; Yager D; Eckman C; Hardy J; Hutton M; McGowan E
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Science (New York, N.Y.) 2001;293(5534):1487-91.
2001: Wszolek Z K; Tsuboi Y; Uitti R J; Reed L; Hutton M L; Dickson D W
Progressive supranuclear palsy as a disease phenotype caused by the S305S tau gene mutation.
Brain : a journal of neurology 2001;124(Pt 8):1666-70.
2001: Litvan I; Baker M; Hutton M
Tau genotype: no effect on onset, symptom severity, or survival in progressive supranuclear palsy.
Neurology 2001;57(1):138-40.
2001: Ertekin-Taner N; Graff-Radford N; Younkin L H; Eckman C; Adamson J; Schaid D J; Blangero J; Hutton M; Younkin S G
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees.
Genetic epidemiology 2001;21(1):19-30.
2001: Wittmann C W; Wszolek M F; Shulman J M; Salvaterra P M; Lewis J; Hutton M; Feany M B
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles.
Science (New York, N.Y.) 2001;293(5530):711-4.
2001: Houlden H; Baker M; Morris H R; MacDonald N; Pickering-Brown S; Adamson J; Lees A J; Rossor M N; Quinn N P; Kertesz A; Khan M N; Hardy J; Lantos P L; St George-Hyslop P; Munoz D G; Mann D; Lang A E; Bergeron C; Bigio E H; Litvan I; Bhatia K P; Dickson D; Wood N W; Hutton M
Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype.
Neurology 2001;56(12):1702-6.
2001: Hutton M
Missense and splice site mutations in tau associated with FTDP-17: multiple pathogenic mechanisms.
Neurology 2001;56(11 Suppl 4):S21-5.
2001: Bigio E H; Vono M B; Satumtira S; Adamson J; Sontag E; Hynan L S; White C L; Baker M; Hutton M
Cortical synapse loss in progressive supranuclear palsy.
Journal of neuropathology and experimental neurology 2001;60(5):403-10.
2001: Bigio E H; Lipton A M; Yen S H; Hutton M L; Baker M; Nacharaju P; White C L; Davies P; Lin W; Dickson D W
Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia.
Journal of neuropathology and experimental neurology 2001;60(4):328-41.
2001: Connell J W; Gibb G M; Betts J C; Blackstock W P; Gallo J; Lovestone S; Hutton M; Anderton B H
Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes.
FEBS letters 2001;493(1):40-4.
2001: Reed L A; Wszolek Z K; Hutton M
Phenotypic correlations in FTDP-17.
Neurobiology of aging 2001;22(1):89-107.
2001: Mack T G; Dayanandan R; Van Slegtenhorst M; Whone A; Hutton M; Lovestone S; Anderton B H
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells.
Neuroscience 2001;108(4):701-12.
2001: Anderton B H; Betts J; Blackstock W P; Brion J P; Chapman S; Connell J; Dayanandan R; Gallo J M; Gibb G; Hanger D P; Hutton M; Kardalinou E; Leroy K; Lovestone S; Mack T; Reynolds C H; Van Slegtenhorst M
Sites of phosphorylation in tau and factors affecting their regulation.
Biochemical Society symposium 2001;(67):73-80.
2000: Ertekin-Taner N; Graff-Radford N; Younkin L H; Eckman C; Baker M; Adamson J; Ronald J; Blangero J; Hutton M; Younkin S G
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Science (New York, N.Y.) 2000;290(5500):2303-4.
2000: Pickering-Brown S; Baker M; Yen S H; Liu W K; Hasegawa M; Cairns N; Lantos P L; Rossor M; Iwatsubo T; Davies Y; Allsop D; Furlong R; Owen F; Hardy J; Mann D; Hutton M
Pick's disease is associated with mutations in the tau gene.
Annals of neurology 2000;48(6):859-67.
2000: Houlden H; Baker M; McGowan E; Lewis P; Hutton M; Crook R; Wood N W; Kumar-Singh S; Geddes J; Swash M; Scaravilli F; Holton J L; Lashley T; Tomita T; Hashimoto T; Verkkoniemi A; Kalimo H; Somer M; Paetau A; Martin J J; Van Broeckhoven C; Golde T; Hardy J; Haltia M; Revesz T
Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations.
Annals of neurology 2000;48(5):806-8.
2000: Lewis J; McGowan E; Rockwood J; Melrose H; Nacharaju P; Van Slegtenhorst M; Gwinn-Hardy K; Paul Murphy M; Baker M; Yu X; Duff K; Hardy J; Corral A; Lin W L; Yen S H; Dickson D W; Davies P; Hutton M
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Nature genetics 2000;25(4):402-5.
2000: van Slegtenhorst M; Lewis J; Hutton M
The molecular genetics of the tauopathies.
Experimental gerontology 2000;35(4):461-71.
2000: Litvan I; Dickson D W; Buttner-Ennever J A; Delacourte A; Hutton M; Dubois B; Golbe L I; Hallett M; Schellenberg G D; Standaert D; Brooks D J; Price D
Research goals in progressive supranuclear palsy. First International Brainstorming Conference on PSP.
Movement disorders : official journal of the Movement Disorder Society 2000;15(3):446-58.
2000: Wszolek Z K; Uitti R J; Hutton M
A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration.
Neurology 2000;54(10):2028-30.
2000: Baker M; Graff-Radford D; Wavrant DeVrièze F; Graff-Radford N; Petersen R C; Kokmen E; Boeve B; Myllykangas L; Polvikoski T; Sulkava R; Verkoniemmi A; Tienari P; Haltia M; Hardy J; Hutton M; Perez-Tur J
No association between TAU haplotype and Alzheimer's disease in population or clinic based series or in familial disease.
Neuroscience letters 2000;285(2):147-9.
2000: Duff K; Knight H; Refolo L M; Sanders S; Yu X; Picciano M; Malester B; Hutton M; Adamson J; Goedert M; Burki K; Davies P
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes.
Neurobiology of disease 2000;7(2):87-98.
2000: Hutton M
"Missing" tau mutation identified.
Annals of neurology 2000;47(4):417-8.
2000: Albers D S; Augood S J; Park L C; Browne S E; Martin D M; Adamson J; Hutton M; Standaert D G; Vonsattel J P; Gibson G E; Beal M F
Frontal lobe dysfunction in progressive supranuclear palsy: evidence for oxidative stress and mitochondrial impairment.
Journal of neurochemistry 2000;74(2):878-81.
2000: DeTure M; Ko L W; Yen S; Nacharaju P; Easson C; Lewis J; van Slegtenhorst M; Hutton M; Yen S H
Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions.
Brain research 2000;853(1):5-14.
2000: Hutton M
Molecular genetics of chromosome 17 tauopathies.
Annals of the New York Academy of Sciences 2000;920():63-73.
1999: Yen S; Easson C; Nacharaju P; Hutton M; Yen S H
FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.
FEBS letters 1999;461(1-2):91-5.
1999: Yen S H; Hutton M; DeTure M; Ko L W; Nacharaju P
Fibrillogenesis of tau: insights from tau missense mutations in FTDP-17.
Brain pathology (Zurich, Switzerland) 1999;9(4):695-705.
1999: Prihar G; Verkkoniem A; Perez-Tur J; Crook R; Lincoln S; Houlden H; Somer M; Paetau A; Kalimo H; Grover A; Myllykangas L; Hutton M; Hardy J; Haltia M
Alzheimer disease PS-1 exon 9 deletion defined.
Nature medicine 1999;5(10):1090.
1999: Froelich S; Houlden H; Rizzu P; Chakraverty S; Baker M; Kwon J; Nowotny P; Isaacs A; Nowotny V; Wauters E; van Baren M J; Oostra B A; Hardy J; Lannfelt L; Goate A; Hutton M; Lendon C L; Heutink P
Construction of a detailed physical and transcript map of the FTDP-17 candidate region on chromosome 17q21.
Genomics 1999;60(2):129-36.
1999: Houlden H; Baker M; Adamson J; Grover A; Waring S; Dickson D; Lynch T; Boeve B; Petersen R C; Pickering-Brown S; Owen F; Neary D; Craufurd D; Snowden J; Mann D; Hutton M
Frequency of tau mutations in three series of non-Alzheimer's degenerative dementia.
Annals of neurology 1999;46(2):243-8.
1999: Pérez-Tur J; Buée L; Morris H R; Waring S C; Onstead L; Wavrant-De Vrièze F; Crook R; Buée-Scherrer V; Hof P R; Petersen R C; McGeer P L; Delacourte A; Hutton M; Siddique T; Ahlskog J E; Hardy J; Steele J C
Neurodegenerative diseases of Guam: analysis of TAU.
Neurology 1999;53(2):411-3.
1999: Prihar G; Gonzalez de Chavez F; Baker M; Crook R; McGowan E; Grover A; Hardy J; Hutton M
A novel candidate presenilin-1 interacting protein containing tetratricopeptide repeats.
Neuroreport 1999;10(7):1409-15.
1999: Grover A; Houlden H; Baker M; Adamson J; Lewis J; Prihar G; Pickering-Brown S; Duff K; Hutton M
5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10.
The Journal of biological chemistry 1999;274(21):15134-43.
1999: Baker M; Litvan I; Houlden H; Adamson J; Dickson D; Perez-Tur J; Hardy J; Lynch T; Bigio E; Hutton M
Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
Human molecular genetics 1999;8(4):711-5.
1999: Nacharaju P; Lewis J; Easson C; Yen S; Hackett J; Hutton M; Yen S H
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.
FEBS letters 1999;447(2-3):195-9.
1999: Dayanandan R; Van Slegtenhorst M; Mack T G; Ko L; Yen S H; Leroy K; Brion J P; Anderton B H; Hutton M; Lovestone S
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation.
FEBS letters 1999;446(2-3):228-32.
1999: Jicha G A; Rockwood J M; Berenfeld B; Hutton M; Davies P
Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins.
Neuroscience letters 1999;260(3):153-6.
1999: Morris H R; Perez-Tur J; Janssen J C; Brown J; Lees A J; Wood N W; Hardy J; Hutton M; Rossor M N
Mutation in the tau exon 10 splice site region in familial frontotemporal dementia.
Annals of neurology 1999;45(2):270-1.
1999: Kehoe P; Wavrant-De Vrieze F; Crook R; Wu W S; Holmans P; Fenton I; Spurlock G; Norton N; Williams H; Williams N; Lovestone S; Perez-Tur J; Hutton M; Chartier-Harlin M C; Shears S; Roehl K; Booth J; Van Voorst W; Ramic D; Williams J; Goate A; Hardy J; Owen M J
A full genome scan for late onset Alzheimer's disease.
Human molecular genetics 1999;8(2):237-45.
1999: Farrer M; Gwinn-Hardy K; Hutton M; Hardy J
The genetics of disorders with synuclein pathology and parkinsonism.
Human molecular genetics 1999;8(10):1901-5.
1998: Hardy J; Duff K; Hardy K G; Perez-Tur J; Hutton M
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.
Nature neuroscience 1998;1(5):355-8.
1998: Wu W S; Holmans P; Wavrant-DeVrièze F; Shears S; Kehoe P; Crook R; Booth J; Williams N; Pérez-Tur J; Roehl K; Fenton I; Chartier-Harlin M C; Lovestone S; Williams J; Hutton M; Hardy J; Owen M J; Goate A
Genetic studies on chromosome 12 in late-onset Alzheimer disease.
JAMA : the journal of the American Medical Association 1998;280(7):619-22.
1998: Isaacs A; Baker M; Wavrant-De Vrièze F; Hutton M
Determination of the gene structure of human GFAP and absence of coding region mutations associated with frontotemporal dementia with parkinsonism linked to chromosome 17.
Genomics 1998;51(1):152-4.
1998: Hutton M; Lendon C L; Rizzu P; Baker M; Froelich S; Houlden H; Pickering-Brown S; Chakraverty S; Isaacs A; Grover A; Hackett J; Adamson J; Lincoln S; Dickson D; Davies P; Petersen R C; Stevens M; de Graaff E; Wauters E; van Baren J; Hillebrand M; Joosse M; Kwon J M; Nowotny P; Che L K; Norton J; Morris J C; Reed L A; Trojanowski J; Basun H; Lannfelt L; Neystat M; Fahn S; Dark F; Tannenberg T; Dodd P R; Hayward N; Kwok J B; Schofield P R; Andreadis A; Snowden J; Craufurd D; Neary D; Owen F; Oostra B A; Hardy J; Goate A; van Swieten J; Mann D; Lynch T; Heutink P
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.
Nature 1998;393(6686):702-5.
1998: Pennypacker K R; Fuldner R; Xu R; Hernandez H; Dawbarn D; Mehta N; Perez-Tur J; Baker M; Hutton M
Cloning and characterization of the presenilin-2 gene promoter.
Brain research. Molecular brain research 1998;56(1-2):57-65.
1998: Crook R; Verkkoniemi A; Perez-Tur J; Mehta N; Baker M; Houlden H; Farrer M; Hutton M; Lincoln S; Hardy J; Gwinn K; Somer M; Paetau A; Kalimo H; Ylikoski R; Pöyhönen M; Kucera S; Haltia M
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.
Nature medicine 1998;4(4):452-5.
1998: Hardy J; Pérez-Tur J; Baker M; Farrer M; Crook R; Hutton M; Johnson W G; Gwinn K; Muenter M; Rocca W A; Maraganore D
Exclusion of genetic linkage to 4q21-23 and 17q21 in a family with Lewy body parkinsonism.
American journal of medical genetics 1998;81(2):166-71.
1998: Houlden H; Crook R; Backhovens H; Prihar G; Baker M; Hutton M; Rossor M; Martin J J; Van Broeckhoven C; Hardy J
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
American journal of medical genetics 1998;81(1):117-21.
1998: Mehta N D; Refolo L M; Eckman C; Sanders S; Yager D; Perez-Tur J; Younkin S; Duff K; Hardy J; Hutton M
Increased Abeta42(43) from cell lines expressing presenilin 1 mutations.
Annals of neurology 1998;43(2):256-8.
1998: Harvey R J; Ellison D; Hardy J; Hutton M; Roques P K; Collinge J; Fox N C; Rossor M N
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Journal of neurology, neurosurgery, and psychiatry 1998;64(1):44-9.
1998: Cruts M; van Duijn C M; Backhovens H; Van den Broeck M; Wehnert A; Serneels S; Sherrington R; Hutton M; Hardy J; St George-Hyslop P H; Hofman A; Van Broeckhoven C
Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease.
Human molecular genetics 1998;7(1):43-51.
1998: Hutton M; Pérez-Tur J; Hardy J
Genetics of Alzheimer's disease.
Essays in biochemistry 1998;33():117-31.
1998: Litvan I; Hutton M
Clinical and genetic aspects of progressive supranuclear palsy.
Journal of geriatric psychiatry and neurology 1998;11(2):107-14.
1997: Lynch T; Farrer M; Hutton M; Hardy J
Genetics of Parkinson's disease.
Science (New York, N.Y.) 1997;278(5341):1212-3.
1997: Baker M; Kwok J B; Kucera S; Crook R; Farrer M; Houlden H; Isaacs A; Lincoln S; Onstead L; Hardy J; Wittenberg L; Dodd P; Webb S; Hayward N; Tannenberg T; Andreadis A; Hallupp M; Schofield P; Dark F; Hutton M
Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21-22.
Annals of neurology 1997;42(5):794-8.
1997: Eckman C B; Mehta N D; Crook R; Perez-tur J; Prihar G; Pfeiffer E; Graff-Radford N; Hinder P; Yager D; Zenk B; Refolo L M; Prada C M; Younkin S G; Hutton M; Hardy J
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Human molecular genetics 1997;6(12):2087-9.
1997: Crook R; Ellis R; Shanks M; Thal L J; Perez-Tur J; Baker M; Hutton M; Haltia T; Hardy J; Galasko D
Early-onset Alzheimer's disease with a presenilin-1 mutation at the site corresponding to the Volga German presenilin-2 mutation.
Annals of neurology 1997;42(1):124-8.
1997: Benkovic S A; McGowan E M; Rothwell N J; Hutton M; Morgan D G; Gordon M N
Regional and cellular localization of presenilin-2 RNA in rat and human brain.
Experimental neurology 1997;145(2 Pt 1):555-64.
1997: Fox N C; Kennedy A M; Harvey R J; Lantos P L; Roques P K; Collinge J; Hardy J; Hutton M; Stevens J M; Warrington E K; Rossor M N
Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.
Brain : a journal of neurology 1997;120 ( Pt 3)():491-501.
1997: Hutton M; Hardy J
The presenilins and Alzheimer's disease.
Human molecular genetics 1997;6(10):1639-46.
1996: Ward R V; Davis J B; Gray C W; Barton A J; Bresciani L G; Caivano M; Murphy V F; Duff K; Hutton M; Hardy J; Roberts G W; Karran E H
Presenilin-1 is processed into two major cleavage products in neuronal cell lines.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(4):293-8.
1996: Duff K; Eckman C; Zehr C; Yu X; Prada C M; Perez-tur J; Hutton M; Buee L; Harigaya Y; Yager D; Morgan D; Gordon M N; Holcomb L; Refolo L; Zenk B; Hardy J; Younkin S
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Nature 1996;383(6602):710-3.
1996: Barton A J; Crook B W; Karran E H; Brown F; Dewar D; Mann D M; Pearson R C; Graham D I; Hardy J; Hutton M; Duff K; Goate A M; Clark R F; Roberts G W
Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):213-8.
1996: Perez-Tur J; Croxton R; Wright K; Phillips H; Zehr C; Crook R; Hutton M; Hardy J; Karran E; Roberts G W; Lancaster S; Haltia T
A further presenilin 1 mutation in the exon 8 cluster in familial Alzheimer's disease.
Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration 1996;5(3):207-12.
1996: Mann D M; Iwatsubo T; Cairns N J; Lantos P L; Nochlin D; Sumi S M; Bird T D; Poorkaj P; Hardy J; Hutton M; Prihar G; Crook R; Rossor M N; Haltia M
Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).
Annals of neurology 1996;40(2):149-56.
1996: Scheuner D; Eckman C; Jensen M; Song X; Citron M; Suzuki N; Bird T D; Hardy J; Hutton M; Kukull W; Larson E; Levy-Lahad E; Viitanen M; Peskind E; Poorkaj P; Schellenberg G; Tanzi R; Wasco W; Lannfelt L; Selkoe D; Younkin S
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Nature medicine 1996;2(8):864-70.
1996: Prihar G; Fuldner R A; Perez-Tur J; Lincoln S; Duff K; Crook R; Hardy J; Philips C A; Venter C; Talbot C; Clark R F; Goate A; Li J; Potter H; Karran E; Roberts G W; Hutton M; Adams M D
Structure and alternative splicing of the presenilin-2 gene.
Neuroreport 1996;7(10):1680-4.
1996: Hutton M; Busfield F; Wragg M; Crook R; Perez-Tur J; Clark R F; Prihar G; Talbot C; Phillips H; Wright K; Baker M; Lendon C; Duff K; Martinez A; Houlden H; Nichols A; Karran E; Roberts G; Roques P; Rossor M; Venter J C; Adams M D; Cline R T; Phillips C A; Goate A
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
Neuroreport 1996;7(3):801-5.
1996: Wragg M; Hutton M; Talbot C
Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group.
Lancet 1996;347(9000):509-12.
1996: Talbot C; Houlden H; Craddock N; Crook R; Hutton M; Lendon C; Prihar G; Morris J C; Hardy J; Goate A
Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.
Neuroreport 1996;7(2):534-6.
1996: Clark R F; Hutton M; Talbot C; Wragg M; Lendon C; Busfield F; Han S W; Perez-Tur J; Adams M; Fuldner R; Roberts G; Karran E; Hardy J; Goate A
The role of presenilin 1 in the genetics of Alzheimer's disease.
Cold Spring Harbor symposia on quantitative biology 1996;61():551-8.
1995: Hardy J; Hutton M
Two new genes for Alzheimer's disease.
Trends in neurosciences 1995;18(10):436.
1995: Houlden H; Crook R; Duff K; Hutton M; Collinge J; Roques P; Rossor M; Hardy J
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
1994: Rempfer R; Crook R; Houlden H; Duff K; Hutton M; Roberts G W; Raghavan R; Perry R; Hardy J
Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene.
Lancet 1994;344(8925):815.
1993: Hutton M L; Harvey R J; Earley F G; Barnard E A; Darlison M G
A novel invertebrate GABAA receptor-like polypeptide. Sequence and pattern of gene expression.
FEBS letters 1993;326(1-3):112-6.
1991: Hutton M L; Harvey R J; Barnard E A; Darlison M G
Cloning of a cDNA that encodes an invertebrate glutamate receptor subunit.
FEBS letters 1991;292(1-2):111-4.

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