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Hinrich Gronemeyer

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Diana Ivanova; Hinrich Gronemeyer; Pablo Steinberg; Heinz Nau
Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.
Patricia García-Domínguez; Hinrich Gronemeyer; Ilaria Lepore; Mélanie Weiss; Rosana Alvarez; Lucia Altucci; Angel R de Lera
A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.
Raquel Pereira; Santiago Pérez-Rodríguez; Fátima Rodríguez-Barrios; Mayra Stuhldreier; Hendrik G Stunnenberg; Lucia Altucci; Rosaria Benedetti; Vincenzo Carafa; Mariarosaria Conte; José García-Rodríguez; Hinrich Gronemeyer; Angela Nebbioso; Angel R de Lera
Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities.

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2013: Diana Ivanova; Hinrich Gronemeyer; Pablo Steinberg; Heinz Nau
Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells.
Archives of toxicology 2013;87(2):303-10.
2012: Patricia García-Domínguez; Hinrich Gronemeyer; Ilaria Lepore; Mélanie Weiss; Rosana Alvarez; Lucia Altucci; Angel R de Lera
A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.
ChemMedChem 2012;7(12):2101-12.
2012: Raquel Pereira; Santiago Pérez-Rodríguez; Fátima Rodríguez-Barrios; Mayra Stuhldreier; Hendrik G Stunnenberg; Lucia Altucci; Rosaria Benedetti; Vincenzo Carafa; Mariarosaria Conte; José García-Rodríguez; Hinrich Gronemeyer; Angela Nebbioso; Angel R de Lera
Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities.
Journal of medicinal chemistry 2012;55(22):9467-91.
2012: Josef B G Gluyas; Hinrich Gronemeyer; Christian Burschka; Steffen Dörrich; Judith Vallet; Reinhold Tacke
Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation.
Organic & biomolecular chemistry 2012;10(34):6914-29.
2012: Pattabhiraman Shankaranarayanan; Luisa M Trindade; Wouter van Gool; Marco-Antonio Mendoza-Parra; Hinrich Gronemeyer
Single-tube linear DNA amplification for genome-wide studies using a few thousand cells.
Nature protocols 2012;7(2):328-38.
2012: Marco A Mendoza-Parra; Martial Sankar; Mannu Walia; Hinrich Gronemeyer
POLYPHEMUS: R package for comparative analysis of RNA polymerase II ChIP-seq profiles by non-linear normalization.
Nucleic acids research 2012;40(4):e30.
2012: Tanveer Sharif; Mahmoud Alhosin; Cyril Auger; Pierre Bories; Christian BRONNER; Nelly Etienne-Selloum; Guy Fuhrmann; Hinrich Gronemeyer; Jong-Hun Kim; Annelise Lobstein; Carole Minker; Valérie B Schini-Kerth
Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells.
PloS one 2012;7(3):e32526.
2012: Albane le Maire; Susana Alvarez; William Bourguet; Pattabhiraman Shankaranarayanan; Angel R de Lera; Hinrich Gronemeyer
Retinoid receptors and therapeutic applications of RAR/RXR modulators.
Current topics in medicinal chemistry 2012;12(6):505-27.
2011: Rosana Alvarez; Lucia Altucci; Hinrich Gronemeyer; Angel R de Lera
Epigenetic multiple modulators.
Current topics in medicinal chemistry 2011;11(22):2749-87.
2011: Patricia García-Domínguez; Hinrich Gronemeyer; Ilaria Lepore; Rosana Alvarez; Lucia Altucci; Cathie Erb; Angel R de Lera
Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B.
Organic & biomolecular chemistry 2011;9(20):6979-87.
2011: Per Lund; Emilie Voltz; William C Hahn; Valérie Kedinger; Harshal Khanwalkar; Irina Kotova; Hinrich Gronemeyer
Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine.
Molecular cancer therapeutics 2011;10(9):1611-23.
2011: Diana Ivanova; Hinrich Gronemeyer; Angel R de Lera
Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells.
ChemMedChem 2011;6(8):1518-29.
2011: Pattabhiraman Shankaranarayanan; Luisa M Trindade; Mannu Walia; Li Wang; Ning Li; Marco-Antonio Mendoza-Parra; Hinrich Gronemeyer
Single-tube linear DNA amplification (LinDA) for robust ChIP-seq.
Nature methods 2011;8(7):565-7.
2011: José García; Hinrich Gronemeyer; Angela Nebbioso; Raquel Pereira; Fátima Rodríguez-Barrios; Lucia Altucci; Rosaria Benedetti; Gianluigi Franci; Angel R de Lera
Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.
Bioorganic & medicinal chemistry 2011;19(12):3637-49.
2011: Danilo Guillermo CESCHIN; Mannu Walia; Sandra Simone Wenk; Carine Duboé; Claudine Gaudon; Yu Xiao; Lucas Fauquier; Martial Sankar; Laurence Vandel; Hinrich Gronemeyer
Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.
Genes & development 2011;25(11):1132-46.
2011: Xiulian Sun; Yili Wu; Bin Chen; Zhuohua Zhang; Weihui Zhou; Yigang Tong; Junying Yuan; Kun Xia; Hinrich Gronemeyer; Richard A Flavell; Weihong Song
Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.
The Journal of biological chemistry 2011;286(11):9049-62.
2011: Valeria Pavet; M M Portal; J C Moulin; Raoul Herbrecht; Hinrich Gronemeyer
Towards novel paradigms for cancer therapy.
Oncogene 2011;30(1):1-20.
2011: Marco A Mendoza-Parra; Martial Sankar; Mannu Walia; Hinrich Gronemeyer
Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics.
Molecular systems biology 2011;7():538.
2011: Valerie Kedinger; Stephanie Muller; Hinrich Gronemeyer
Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis.
Molecular cancer 2011;10():34.
2011: Susana Alvarez; William Bourguet; Hinrich Gronemeyer; Angel R de Lera
Retinoic acid receptor modulators: a perspective on recent advances and promises.
Expert opinion on therapeutic patents 2011;21(1):55-63.
2010: Angela Nebbioso; Carmela Dell'Aversana; Anne Bugge; Roberta Sarno; Sergio Valente; dante rotili; Fabio Manzo; Diana Teti; Susanne Mandrup; Paolo Ciana; Adriana Maggi; Antonello Mai; Hinrich Gronemeyer; Lucia Altucci
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.
Journal of molecular endocrinology 2010;45(4):219-28.
2010: Albane le Maire; Catherine Teyssier; Cathie Erb; Marina Grimaldi; Susana Alvarez; Angel R de Lera; Patrick Balaguer; Hinrich Gronemeyer; Catherine A Royer; Pierre Germain; William Bourguet
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
Nature structural & molecular biology 2010;17(7):801-7.
2010: Jan-Henrik Mikesch; Hinrich Gronemeyer; Chi Wai Eric So
Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge.
Cancer cell 2010;17(2):112-4.
2010: Valeria Pavet; Julien Beyrath; Christophe Pardin; Alexandre Morizot; Marie-Charlotte Lechner; Jean-Paul Briand; Miriam Wendland; Wolfgang Maison; Sylvie Fournel; Olivier Micheau; Gilles Guichard; Hinrich Gronemeyer
Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity.
Cancer research 2010;70(3):1101-10.
2010: Jihui J Qiu; Xiaoxi Lu; Bernd B Zeisig; Zhigui Ma; Xun Cai; Saijuan Chen; Hinrich Gronemeyer; David Tweardy; Chi Wai Eric So; Shuo Dong
Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.
Blood 2010;115(3):643-52.
2010: William Bourguet; Angel R de Lera; Hinrich Gronemeyer
Inverse agonists and antagonists of retinoid receptors.
Methods in enzymology 2010;485():161-95.
2010: Ana M Jiménez-Lara; Ana Aranda; Hinrich Gronemeyer
Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.
Molecular cancer 2010;9():15.
2009: Reinhold Tacke; Volker Müller; Matthias W Büttner; W Peter Lippert; Rüdiger Bertermann; Jürgen O Daiss; Harshal Khanwalkar; Audrey Furst; Claudine Gaudon; Hinrich Gronemeyer
Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.
ChemMedChem 2009;4(11):1797-802.
2009: Susana Alvarez; Harshal Khanwalkar; Rosana Alvarez; Cathie Erb; Claudio Martínez; Fátima Rodríguez-Barrios; Pierre Germain; Hinrich Gronemeyer; Angel R de Lera
C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function.
ChemMedChem 2009;4(10):1630-40.
2009: Pattabhiraman Shankaranarayanan; Aurélie Rossin; Harshal Khanwalkar; Susana Alvarez; Rosana Alvarez; Annica Jacobson; Angela Nebbioso; Angel R de Lera; Lucia Altucci; Hinrich Gronemeyer
Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.
Cancer cell 2009;16(3):220-31.
2009: L Galluzzi; S A Aaronson; J Abrams; E S Alnemri; D W Andrews; E H Baehrecke; N G Bazan; M V Blagosklonny; K Blomgren; C Borner; Dale E Bredesen; C Brenner; M Castedo; J A Cidlowski; Aaron Ciechanover; G M Cohen; V De Laurenzi; R De Maria; Mohanish Deshmukh; Brian David Dynlacht; Wafik S El-Deiry; R A Flavell; S Fulda; C Garrido; P Golstein; M-L Gougeon; D R Green; Hinrich Gronemeyer; Gyorgy Hajn\u2264czky; J Marie Hardwick; M O Hengartner; H Ichijo; M Jäättelä; O Kepp; A Kimchi; Daniel J Klionsky; R A Knight; Sally Kornbluth; S Kumar; Beth Levine; S A Lipton; E Lugli; F Madeo; W Malomi; J-C W Marine; S J Martin; J P Medema; P Mehlen; G Melino; Ute M Moll; E Morselli; S Nagata; D W Nicholson; P Nicotera; G Nuñez; M Oren; J Penninger; S Pervaiz; M E Peter; M Piacentini; J H M Prehn; H Puthalakath; G A Rabinovich; R Rizzuto; C M P Rodrigues; David C Rubinsztein; T Rudel; LUCA SCORRANO; H-U Simon; H Steller; J Tschopp; Y Tsujimoto; P Vandenabeele; I Vitale; K H Vousden; R J Youle; J Yuan; B Zhivotovsky; G Kroemer
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell death and differentiation 2009;16(8):1093-107.
2009: Angela Nebbioso; Fabio Manzo; Marco Miceli; Mariarosaria Conte; Lucrezia Manente; Alfonso Baldi; Antonio De Luca; Dante Rotili; Sergio Valente; Antonello Mai; Alessandro Usiello; Hinrich Gronemeyer; Lucia Altucci
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
EMBO reports 2009;10(7):776-82.
2009: W Peter Lippert; Christian Burschka; Kathrin Götz; Martin Kaupp; Diana Ivanova; Claudine Gaudon; Yoshiteru Sato; Pierre Antony; Natacha Rochel; Dino Moras; Hinrich Gronemeyer; Reinhold Tacke
Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.
ChemMedChem 2009;4(7):1143-52.
2009: Susana Alvarez; Rosana Alvarez; Harshal Khanwalkar; Pierre Germain; Géraldine Lemaire; Fátima Rodríguez-Barrios; Hinrich Gronemeyer; Angel R de Lera
Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.
Bioorganic & medicinal chemistry 2009;17(13):4345-59.
2009: Pierre Germain; Claudine Gaudon; Vivian Pogenberg; Sarah Sanglier; Alain Van Dorsselaer; Catherine A Royer; Mitchell Lazar; William Bourguet; Hinrich Gronemeyer
Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.
Chemistry & biology 2009;16(5):479-89.
2009: Efrén Pérez Santín; Pierre Germain; Fabien Quillard; Harshal Khanwalkar; Fátima Rodríguez-Barrios; Hinrich Gronemeyer; Angel R de Lera; William Bourguet
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
Journal of medicinal chemistry 2009;52(10):3150-8.
2009: José García; Harshal Khanwalkar; Raquel Pereira; Cathie Erb; Johannes J Voegel; Pascal Collette; Pascale Mauvais; William Bourguet; Hinrich Gronemeyer; Angel R de Lera
Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors.
Chembiochem : a European journal of chemical biology 2009;10(7):1252-9.
2009: Efrén Pérez Santín; Harshal Khanwalkar; Johannes Voegel; Pascal Collette; Pascale Mauvais; Hinrich Gronemeyer; Angel R de Lera
Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem 2009;4(5):780-91.
2009: Hinrich Gronemeyer; Arthur Zelent
Fingering modulators of retinoic acid signaling identifies new prognostic marker for neuroblastoma.
Cancer cell 2009;15(4):249-51.
2009: Hinrich Gronemeyer; William Bourguet
Allosteric effects govern nuclear receptor action: DNA appears as a player.
Science signaling 2009;2(73):pe34.
2008: Susana Alvarez; Yolanda Pazos-Randulfe; Harshal Khanwalkar; Pierre Germain; Rosana Alvarez; Hinrich Gronemeyer; Angel R de Lera
New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Bioorganic & medicinal chemistry 2008;16(22):9719-28.
2008: Elisabetta Caselli; Monica Galvan; Fabio Santoni; Susana Alvarez; Angel R de Lera; Diana Ivanova; Hinrich Gronemeyer; Arnaldo Caruso; Massimo Guidoboni; Enzo Cassai; Riccardo Dolcetti; Dario Di Luca
Retinoic acid analogues inhibit human herpesvirus 8 replication.
Antiviral therapy 2008;13(2):199-209.
2008: Emilie Voltz; Hinrich Gronemeyer
A new era of cancer therapy: cancer cell targeted therapies are coming of age.
The international journal of biochemistry & cell biology 2008;40(1):1-8.
2007: Mirjam T Epping; Liming Wang; Jane A Plumb; Michele Lieb; Hinrich Gronemeyer; Robert Brown; René Bernards
A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17777-82.
2007: Virginie Nahoum; Efrén Pérez; Pierre Germain; Fátima Rodríguez-Barrios; Fabio Manzo; Sabrina Kammerer; Géraldine Lemaire; Oliver Hirsch; Catherine A Royer; Hinrich Gronemeyer; Angel R de Lera; William Bourguet
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17323-8.
2007: Angel R de Lera; William Bourguet; Lucia Altucci; Hinrich Gronemeyer
Design of selective nuclear receptor modulators: RAR and RXR as a case study.
Nature reviews. Drug discovery 2007;6(10):811-20.
2007: Lucia Altucci; Mark D Leibowitz; Kathleen M Ogilvie; Angel R de Lera; Hinrich Gronemeyer
RAR and RXR modulation in cancer and metabolic disease.
Nature reviews. Drug discovery 2007;6(10):793-810.
2007: Matthias W Büttner; Christian Burschka; Jürgen O Daiss; Diana Ivanova; Natacha Rochel; Sabrina Kammerer; Carole Peluso-Iltis; Audrey Bindler; Claudine Gaudon; Pierre Germain; Dino Moras; Hinrich Gronemeyer; Reinhold Tacke
Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology.
Chembiochem : a European journal of chemical biology 2007;8(14):1688-99.
2007: Bernd B Zeisig; Colin Kwok; Arthur Zelent; Pattabhiraman Shankaranarayanan; Hinrich Gronemeyer; Shuo Dong; Chi Wai So
Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.
Cancer cell 2007;12(1):36-51.
2007: Michael Tsapis; Michèle Lieb; Fabio Manzo; Pattabhiraman Shankaranarayanan; Raoul Herbrecht; Patrick Lutz; Hinrich Gronemeyer
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
The international journal of biochemistry & cell biology 2007;39(7-8):1500-9.
2007: Susana Alvarez; Pierre Germain; Rosana Alvarez; Fátima Rodríguez-Barrios; Hinrich Gronemeyer; Angel R de Lera
Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
The international journal of biochemistry & cell biology 2007;39(7-8):1406-15.
2006: Raquel Pereira; Audrey Furst; Beatriz Iglesias; Pierre Germain; Hinrich Gronemeyer; Angel R de Lera
Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARbeta/delta agonists.
Organic & biomolecular chemistry 2006;4(24):4514-25.
2006: Pierre Germain; Pierre Chambon; Gregor Eichele; Ronald M Evans; Mitchell Lazar; Mark Leid; Angel R de Lera; Reuben Lotan; David J Mangelsdorf; Hinrich Gronemeyer
International Union of Pharmacology. LXIII. Retinoid X receptors.
Pharmacological reviews 2006;58(4):760-72.
2006: Pierre Germain; Pierre Chambon; Gregor Eichele; Ronald M Evans; Mitchell Lazar; Mark Leid; Angel R de Lera; Reuben Lotan; David J Mangelsdorf; Hinrich Gronemeyer
International Union of Pharmacology. LX. Retinoic acid receptors.
Pharmacological reviews 2006;58(4):712-25.
2006: Hector Escriva; Stéphanie Bertrand; Pierre Germain; Marc Robinson-Rechavi; Muriel Umbhauer; Jérôme Cartry; Marilyne Duffraisse; Linda Holland; Hinrich Gronemeyer; Vincent Laudet
Neofunctionalization in vertebrates: the example of retinoic acid receptors.
PLoS genetics 2006;2(7):e102.
2006: W Yin; Aurélie Rossin; J L Clifford; Hinrich Gronemeyer
Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.
Oncogene 2006;25(26):3735-44.
2006: Laszlo Nagy; Roland Schüle; Hinrich Gronemeyer
Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.
EMBO reports 2006;7(6):579-84.
2006: Darja Obradovic; Hinrich Gronemeyer; Beat Lutz; Theo Rein
Cross-talk of vitamin D and glucocorticoids in hippocampal cells.
Journal of neurochemistry 2006;96(2):500-9.
2006: Raquel Pereira; Claudine Gaudon; Beatriz Iglesias; Pierre Germain; Hinrich Gronemeyer; Angel R de Lera
Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.
Bioorganic & medicinal chemistry letters 2006;16(1):49-54.
2005: Yan-Ru Lou; Susanna Miettinen; Hiroyuki Kagechika; Hinrich Gronemeyer; Pentti Tuohimaa
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Biochemical and biophysical research communications 2005;338(4):1973-81.
2005: Lucia Altucci; Aurélie Rossin; Oliver Hirsch; Angela Nebbioso; Dominique VITOUX; Emmanuelle Wilhelm; Fabien Guidez; Mariacarla De Simone; Ettore Mariano Schiavone; David Grimwade; Arthur Zelent; Hugues de Thé; Hinrich Gronemeyer
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
Cancer research 2005;65(19):8754-65.
2005: Lucia Altucci; Nicole Clarke; Angela Nebbioso; Annamaria Scognamiglio; Hinrich Gronemeyer
Acute myeloid leukemia: therapeutic impact of epigenetic drugs.
The international journal of biochemistry & cell biology 2005;37(9):1752-62.
2005: Weihong Yin; Wolfgang Raffelsberger; Hinrich Gronemeyer
Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs.
The international journal of biochemistry & cell biology 2005;37(8):1696-708.
2005: Nicole Clarke; Angela Nebbioso; Lucia Altucci; Hinrich Gronemeyer
TRAIL: at the center of drugable anti-tumor pathways.
Cell cycle (Georgetown, Tex.) 2005;4(7):914-8.
2005: Vivian Pogenberg; Jean-François Guichou; Valerie Vivat Hannah; Sabrina Kammerer; Efrén Pérez; Pierre Germain; Angel R de Lera; Hinrich Gronemeyer; Catherine A Royer; William Bourguet
Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
The Journal of biological chemistry 2005;280(2):1625-33.
2005: Angela Nebbioso; Nicole Clarke; Emilie Voltz; emmanuelle germain; Concetta Ambrosino; Paola Bontempo; Rosana Alvarez; Ettore Mariano Schiavone; Felicetto Ferrara; Francesco Bresciani; Alessandro Weisz; Angel R de Lera; Hinrich Gronemeyer; Lucia Altucci
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.
Nature medicine 2005;11(1):77-84.
2004: Rosana Alvarez; M Jesús Vega; Sabrina Kammerer; Aurélie Rossin; Pierre Germain; Hinrich Gronemeyer; Angel R de Lera
9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.
Bioorganic & medicinal chemistry letters 2004;14(24):6117-22.
2004: Sarah Sanglier; William Bourguet; Pierre Germain; Virginie Chavant; Dino Moras; Hinrich Gronemeyer; Noelle Potier; Alain Van Dorsselaer
Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry.
European journal of biochemistry / FEBS 2004;271(23-24):4958-67.
2004: Nicole Clarke; Pierre Germain; Lucia Altucci; Hinrich Gronemeyer
Retinoids: potential in cancer prevention and therapy.
Expert reviews in molecular medicine 2004;6(25):1-23.
2004: Hinrich Gronemeyer; Jan-�ke GUSTAFSSON; Vincent Laudet
Principles for modulation of the nuclear receptor superfamily.
Nature reviews. Drug discovery 2004;3(11):950-64.
2004: Sabrina Kammerer; Pierre Germain; Ralf Flaig; Carole Peluso-Iltis; Andre Mitschler; Natacha Rochel; Hinrich Gronemeyer; Dino Moras
RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 11):2048-50.
2004: Ana M Jiménez-Lara; Nicole Clarke; Lucia Altucci; Hinrich Gronemeyer
Retinoic-acid-induced apoptosis in leukemia cells.
Trends in molecular medicine 2004;10(10):508-15.
2004: Pierre Germain; Sabrina Kammerer; Efrén Pérez; Carole Peluso-Iltis; David Tortolani; F Christopher Zusi; John E Starrett; Philippe Lapointe; Jean-Paul Daris; Anne Marinier; Angel R de Lera; Natacha Rochel; Hinrich Gronemeyer
Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.
EMBO reports 2004;5(9):877-82.
2004: Diana Ivanova; Aurélie Rossin; Hinrich Gronemeyer; Alain Valla; Dominique Cartier; Régis Le Guillou; Roger Labia
Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.
Bioorganic & medicinal chemistry letters 2004;14(16):4257-61.
2004: Nicole Clarke; Ana M Jimenez-Lara; Emilie Voltz; Hinrich Gronemeyer
Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL.
The EMBO journal 2004;23(15):3051-60.
2004: D Obradović; Marilyn Tirard; Zs Némethy; Oliver Hirsch; Hinrich Gronemeyer; Osborne Almeida
DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors?
Molecular pharmacology 2004;65(3):761-9.
2004: Lucia Altucci; Emmanuelle Wilhelm; Hinrich Gronemeyer
Leukemia: beneficial actions of retinoids and rexinoids.
The international journal of biochemistry & cell biology 2004;36(2):178-82.
2004: Lucia Altucci; Hinrich Gronemeyer
Retinoids and TRAIL: two cooperating actors to fight against cancer.
Vitamins and hormones 2004;67():319-45.
2003: Valerie Vivat Hannah; William Bourguet; Marco Gottardis; Hinrich Gronemeyer
Separation of retinoid X receptor homo- and heterodimerization functions.
Molecular and cellular biology 2003;23(21):7678-88.
2002: Martin Bommer; Arndt Benecke; Hinrich Gronemeyer; Cécile Rochette-Egly
TIF2 mediates the synergy between RARalpha 1 activation functions AF-1 and AF-2.
The Journal of biological chemistry 2002;277(40):37961-6.
2002: Wolfgang Raffelsberger; Doulaye Dembélé; Mike G Neubauer; Marco Gottardis; Hinrich Gronemeyer
Quality indicators increase the reliability of microarray data.
Genomics 2002;80(4):385-94.
2002: Ana M Jiménez-Lara; Mattias J S Heine; Hinrich Gronemeyer
PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2.
FEBS letters 2002;526(1-3):142-6.
2002: Martine Gehin; Manuel Mark; Christine Dennefeld; Andrée Dierich; Hinrich Gronemeyer; Pierre Chambon
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.
Molecular and cellular biology 2002;22(16):5923-37.
2002: Diana Ivanova; Claudine Gaudon; Aurélie Rossin; William Bourguet; Hinrich Gronemeyer
RAR-RXR selectivity and biological activity of new retinoic acid analogues with heterocyclic or polycyclic aromatic systems.
Bioorganic & medicinal chemistry 2002;10(7):2099-102.
2002: Hector Escriva; Nicholas D Holland; Hinrich Gronemeyer; Vincent Laudet; Linda Z Holland
The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest.
Development (Cambridge, England) 2002;129(12):2905-16.
2002: Lucia Altucci; Hinrich Gronemeyer
Decryption of the retinoid death code in leukemia.
Journal of clinical immunology 2002;22(3):117-23.
2002: Pierre Germain; Jaya Iyer; Christina Zechel; Hinrich Gronemeyer
Co-regulator recruitment and the mechanism of retinoic acid receptor synergy.
Nature 2002;415(6868):187-92.
2001: Lucia Altucci; Hinrich Gronemeyer
The promise of retinoids to fight against cancer.
Nature reviews. Cancer 2001;1(3):181-93.
2001: Lucia Altucci; Hinrich Gronemeyer
Nuclear receptors in cell life and death.
Trends in endocrinology and metabolism: TEM 2001;12(10):460-8.
2001: GR Benoit; Maria Flexor; Françoise Besançon; Lucia Altucci; Aurélie Rossin; Josette Hillion; Zoltán Balajthy; Luc LEGRES; Evelyne Ségal-Bendirdjian; Hinrich Gronemeyer; Michel Lanotte
Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells.
Molecular endocrinology (Baltimore, Md.) 2001;15(7):1154-69.
2001: Lucia Altucci; Aurélie Rossin; Wolfgang Raffelsberger; Armin Reitmair; C Chomienne; Hinrich Gronemeyer
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.
Nature medicine 2001;7(6):680-6.
2001: Hinrich Gronemeyer; R Miturski
Molecular mechanisms of retinoid action.
Cellular & molecular biology letters 2001;6(1):3-52.
2000: William Bourguet; Pierre Germain; Hinrich Gronemeyer
Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications.
Trends in pharmacological sciences 2000;21(10):381-8.
2000: Arndt Benecke; Pierre Chambon; Hinrich Gronemeyer
Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.
EMBO reports 2000;1(2):151-7.
2000: William Bourguet; V Andry; C Iltis; Bruno Klaholz; Noelle Potier; Alain Van Dorsselaer; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Heterodimeric complex of RAR and RXR nuclear receptor ligand-binding domains: purification, crystallization, and preliminary X-ray diffraction analysis.
Protein expression and purification 2000;19(2):284-8.
2000: A M Jimenez-Lara; Mattias J S Heine; Hinrich Gronemeyer
Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family.
FEBS letters 2000;468(2-3):203-10.
2000: William Bourguet; Valerie Vivat Hannah; Jean-Marie Wurtz; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
Molecular cell 2000;5(2):289-98.
1999: B He; J A Kemppainen; J J Voegel; Hinrich Gronemeyer; Elizabeth M Wilson
Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain.
The Journal of biological chemistry 1999;274(52):37219-25.
1999: GR Benoit; Lucia Altucci; Maria Flexor; S Ruchaud; Johan R Lillehaug; Wolfgang Raffelsberger; Hinrich Gronemeyer; Michel Lanotte
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
The EMBO journal 1999;18(24):7011-8.
1999: Motohiro Ebisawa; H Umemiya; Keisuke Ohta; Hiroshi Fukasawa; Emiko Kawachi; G Christoffel; Hinrich Gronemeyer; M Tsuji; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Chemical & pharmaceutical bulletin 1999;47(12):1778-86.
1999: Hinrich Gronemeyer
Structure and function of nuclear receptors--EMBO workshop. 25-27 May 1999, Villefranche-sur-Mer, Nice, France.
IDrugs : the investigational drugs journal 1999;2(8):760-2.
1999: M Géhin; Valerie Vivat Hannah; Jean-Marie Wurtz; Régine Losson; Pierre Chambon; Dino Moras; Hinrich Gronemeyer
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Chemistry & biology 1999;6(8):519-29.
1999: Jaya Iyer; D Bonnier; Florence Granger; C Iltis; V Andry; Patrick Schultz; Hinrich Gronemeyer
Versatile copurification procedure for rapid isolation of homogeneous RAR-RXR heterodimers.
Protein expression and purification 1999;16(2):308-14.
1998: Hinrich Gronemeyer
Receptor mechanisms: principles of agonism. 23-25 July 1998, Merano, Italy.
IDrugs : the investigational drugs journal 1998;1(6):657-9.
1998: Michèle Resche-Rigon; Hinrich Gronemeyer
Therapeutic potential of selective modulators of nuclear receptor action.
Current opinion in chemical biology 1998;2(4):501-7.
1998: D Moras; Hinrich Gronemeyer
The nuclear receptor ligand-binding domain: structure and function.
Current opinion in cell biology 1998;10(3):384-91.
1998: Bruno Klaholz; Jean-Paul Renaud; Andre Mitschler; C Zusi; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nature structural biology 1998;5(3):199-202.
1998: J J Voegel; Mattias J S Heine; M Tini; Valerie Vivat Hannah; Pierre Chambon; Hinrich Gronemeyer
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
The EMBO journal 1998;17(2):507-19.
1998: Z P Chen; Jaya Iyer; William Bourguet; P Held; Charles Mioskowski; Luc Lebeau; Noa Noy; P Chambon; Hinrich Gronemeyer
Ligand- and DNA-induced dissociation of RXR tetramers.
Journal of molecular biology 1998;275(1):55-65.
1998: Timo Ylikomi; Jean-Marie Wurtz; Heimo Syvälä; S Passinen; A Pekki; M Haverinen; Merja Bläuer; Pentti Tuohimaa; Hinrich Gronemeyer
Reappraisal of the role of heat shock proteins as regulators of steroid receptor activity.
Critical reviews in biochemistry and molecular biology 1998;33(6):437-66.
1998: Hamid Morjani; Abdelilah Beljebbar; Ganesh Dhruvananda Sockalingum; T A Mattioli; D Bonnier; Hinrich Gronemeyer; Michel Manfait
Surface-enhanced Raman scattering and fluorescence spectroscopy reveal molecular interactions of all-trans retinoic acid and RAR gamma ligand-binding domain.
Biospectroscopy 1998;4(5):297-302.
1997: H Umemiya; Hiroshi Fukasawa; Motohiro Ebisawa; L Eyrolles; Emiko Kawachi; G Eisenmann; Hinrich Gronemeyer; Yuichi Hashimoto; Koichi Shudo; Hiroyuki Kagechika
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Journal of medicinal chemistry 1997;40(26):4222-34.
1997: Valerie Vivat Hannah; C Zechel; Jean-Marie Wurtz; William Bourguet; Hiroyuki Kagechika; H Umemiya; Koichi Shudo; Dino Moras; Hinrich Gronemeyer; Pierre Chambon
A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.
The EMBO journal 1997;16(18):5697-709.
1997: Béatrice Vayssière; S Dupont; A Choquart; F Petit; T Garcia; C Marchandeau; Hinrich Gronemeyer; Michèle Resche-Rigon
Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo.
Molecular endocrinology (Baltimore, Md.) 1997;11(9):1245-55.
1997: S Kersten; Hinrich Gronemeyer; Noa Noy
The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state.
The Journal of biological chemistry 1997;272(19):12771-7.
1997: H Umemiya; Hiroyuki Kagechika; Hiroshi Fukasawa; Emiko Kawachi; Motohiro Ebisawa; Yuichi Hashimoto; G Eisenmann; C Erb; A Pornon; Pierre Chambon; Hinrich Gronemeyer; Koichi Shudo
Action mechanism of retinoid-synergistic dibenzodiazepines.
Biochemical and biophysical research communications 1997;233(1):121-5.
1997: Valerie Vivat Hannah; D Gofflo; T Garcia; Jean-Marie Wurtz; William Bourguet; D Philibert; Hinrich Gronemeyer
Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities.
Journal of molecular endocrinology 1997;18(2):147-60.
1997: Natacha Rochel; Jean-Paul Renaud; Marc Ruff; Valerie Vivat Hannah; Florence Granger; D Bonnier; Thierry Lerouge; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.
Biochemical and biophysical research communications 1997;230(2):293-6.
1996: S Roux; Béatrice Térouanne; Patrick Balaguer; N Jausons-Loffreda; M Pons; P Chambon; Hinrich Gronemeyer; Jean-Claude Nicolas
Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1996;10(10):1214-26.
1996: M Gérard; J Y Chen; Hinrich Gronemeyer; P Chambon; Denis Duboule; József Zákány
In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries.
Genes & development 1996;10(18):2326-34.
1996: J Y Chen; J Clifford; C Zusi; John E Starrett; D Tortolani; J Ostrowski; P R Reczek; Pierre Chambon; Hinrich Gronemeyer
Two distinct actions of retinoid-receptor ligands.
Nature 1996;382(6594):819-22.
1996: J J Voegel; M J Heine; C Zechel; Pierre Chambon; Hinrich Gronemeyer
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.
The EMBO journal 1996;15(14):3667-75.
1996: B Le Douarin; Elmar vom Baur; C Zechel; D Heery; M Heine; Valerie Vivat Hannah; Hinrich Gronemeyer; Régine Losson; Pierre Chambon
Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators).
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):569-78.
1996: Jean-Marie Wurtz; William Bourguet; Jean-Paul Renaud; Valerie Vivat Hannah; Pierre Chambon; Dino Moras; Hinrich Gronemeyer
A canonical structure for the ligand-binding domain of nuclear receptors.
Nature structural biology 1996;3(2):206.
1996: Elmar vom Baur; C Zechel; D Heery; M J Heine; Jean-Marie Garnier; Valerie Vivat Hannah; B Le Douarin; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
The EMBO journal 1996;15(1):110-24.
1996: Jean-Marie Wurtz; William Bourguet; Jean-Paul Renaud; Valerie Vivat Hannah; Pierre Chambon; Dino Moras; Hinrich Gronemeyer
A canonical structure for the ligand-binding domain of nuclear receptors.
Nature structural biology 1996;3(1):87-94.
1995: Jean-Paul Renaud; N Rochel; Marc Ruff; Valerie Vivat Hannah; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
Nature 1995;378(6558):681-9.
1995: Shigeaki Kato; H Sasaki; Miyuki Suzawa; Shoichi Masushige; Làszlò Tora; P Chambon; Hinrich Gronemeyer
Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
Molecular and cellular biology 1995;15(11):5858-67.
1995: S Kersten; L Pan; P Chambon; Hinrich Gronemeyer; Noa Noy
Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor.
Biochemistry 1995;34(42):13717-21.
1995: William Bourguet; Marc Ruff; D Bonnier; F Granger; M Boeglin; Pierre Chambon; Dino Moras; Hinrich Gronemeyer
Purification, functional characterization, and crystallization of the ligand binding domain of the retinoid X receptor.
Protein expression and purification 1995;6(5):604-8.
1995: S Kersten; D Kelleher; P Chambon; Hinrich Gronemeyer; Noa Noy
Retinoid X receptor alpha forms tetramers in solution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8645-9.
1995: William Bourguet; Marc Ruff; Pierre Chambon; Hinrich Gronemeyer; Dino Moras
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
Nature 1995;375(6530):377-82.
1995: Hinrich Gronemeyer; D Moras
Nuclear receptors. How to finger DNA.
Nature 1995;375(6528):190-1.
1995: B Le Douarin; C Zechel; Jean-Marie Garnier; Yves Lutz; Làszlò Tora; P Pierrat; D Heery; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
The EMBO journal 1995;14(9):2020-33.
1995: J Y Chen; S Penco; J Ostrowski; Patrick Balaguer; M Pons; John E Starrett; P Reczek; Pierre Chambon; Hinrich Gronemeyer
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
The EMBO journal 1995;14(6):1187-97.
1995: Hinrich Gronemeyer; V Laudet
Transcription factors 3: nuclear receptors.
Protein profile 1995;2(11):1173-308.
1994: Z P Chen; L Shemshedini; B Durand; N Noy; Pierre Chambon; Hinrich Gronemeyer
Pure and functionally homogeneous recombinant retinoid X receptor.
The Journal of biological chemistry 1994;269(41):25770-6.
1994: C Zechel; X Q Shen; J Y Chen; Z P Chen; Pierre Chambon; Hinrich Gronemeyer
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
The EMBO journal 1994;13(6):1425-33.
1994: C Zechel; X Q Shen; Pierre Chambon; Hinrich Gronemeyer
Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.
The EMBO journal 1994;13(6):1414-24.
1994: D M Heery; Benoit Pierrat; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Homo- and heterodimers of the retinoid X receptor (RXR) activated transcription in yeast.
Nucleic acids research 1994;22(5):726-31.
1993: S Mader; J Y Chen; Z Chen; J White; Pierre Chambon; Hinrich Gronemeyer
The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.
The EMBO journal 1993;12(13):5029-41.
1993: F Rudert; Hinrich Gronemeyer
Retinoic acid-response elements with a highly repetitive structure isolated by immuno-selection from genomic DNA.
The Journal of steroid biochemistry and molecular biology 1993;46(2):121-33.
1993: D M Heery; Timothy R Zacharewski; Benoit Pierrat; Hinrich Gronemeyer; Pierre Chambon; Régine Losson
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4281-5.
1993: M T Bocquel; J Ji; Timo Ylikomi; B Benhamou; A Vergezac; Pierre Chambon; Hinrich Gronemeyer
Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization.
The Journal of steroid biochemistry and molecular biology 1993;45(4):205-15.
1993: Hinrich Gronemeyer
Transcription activation by nuclear receptors.
Journal of receptor research 1993;13(1-4):667-91.
1992: T Garcia; B Benhamou; D Gofflo; A Vergezac; D Philibert; Pierre Chambon; Hinrich Gronemeyer
Switching agonistic, antagonistic, and mixed transcriptional responses to 11 beta-substituted progestins by mutation of the progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2071-8.
1992: A P Reddy; J Y Chen; T Zacharewski; Hinrich Gronemeyer; John J Voorhees; Gary J Fisher
Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system.
The Biochemical journal 1992;287 ( Pt 3)():833-40.
1992: Timo Ylikomi; M T Bocquel; M Berry; Hinrich Gronemeyer; Pierre Chambon
Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.
The EMBO journal 1992;11(10):3681-94.
1992: M E Meyer; C Quirin-Stricker; Thierry Lerouge; M T Bocquel; Hinrich Gronemeyer
A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.
The Journal of biological chemistry 1992;267(15):10882-7.
1992: Hinrich Gronemeyer
Control of transcription activation by steroid hormone receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(8):2524-9.
1992: Hinrich Gronemeyer; B Benhamou; M Berry; M T Bocquel; D Gofflo; T Garcia; Thierry Lerouge; Daniel Metzger; M E Meyer; Làszlò Tora
Mechanisms of antihormone action.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):217-21.
1992: L Shemshedini; J W Ji; C Brou; Pierre Chambon; Hinrich Gronemeyer
In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors.
The Journal of biological chemistry 1992;267(3):1834-9.
1992: B Benhamou; T Garcia; Thierry Lerouge; A Vergezac; D Gofflo; C Bigogne; Pierre Chambon; Hinrich Gronemeyer
A single amino acid that determines the sensitivity of progesterone receptors to RU486.
Science (New York, N.Y.) 1992;255(5041):206-9.
1991: L Shemshedini; R Knauthe; Paolo Sassone-Corsi; A Pornon; Hinrich Gronemeyer
Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.
The EMBO journal 1991;10(12):3839-49.
1991: B Turcotte; M E Meyer; M Bellard; G Dretzen; Hinrich Gronemeyer; Pierre Chambon
Control of transcription of the chicken progesterone receptor gene. In vitro and in vivo studies.
The Journal of biological chemistry 1991;266(4):2582-9.
1991: Hinrich Gronemeyer; M E Meyer; M T Bocquel; Philippe Kastner; B Turcotte; Pierre Chambon
Progestin receptors: isoforms and antihormone action.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):271-8.
1991: Patrick Balaguer; E Demirpence; M Pons; D Gagne; M T Bocquel; Hinrich Gronemeyer; Jean-Claude Nicolas
[Retinoic acid has an antiestrogenic effect on different regulated estrogen genes in different cellular types].
Comptes rendus des séances de la Société de biologie et de ses filiales 1991;185(6):434-43.
1991: Hinrich Gronemeyer; M E Meyer
[Nuclear receptors. Hormones, anti-hormones and regulation of the transcription].
Annales d'endocrinologie 1991;52(5):335-8.
1991: Hinrich Gronemeyer
Transcription activation by estrogen and progesterone receptors.
Annual review of genetics 1991;25():89-123.
1990: M E Meyer; A Pornon; J W Ji; M T Bocquel; Pierre Chambon; Hinrich Gronemeyer
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.
The EMBO journal 1990;9(12):3923-32.
1990: Philippe Kastner; M T Bocquel; B Turcotte; Jean-Marie Garnier; K B Horwitz; Pierre Chambon; Hinrich Gronemeyer
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.
The Journal of biological chemistry 1990;265(21):12163-7.
1990: Philippe Kastner; A Krust; B Turcotte; U Stropp; Làszlò Tora; Hinrich Gronemeyer; Pierre Chambon
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
The EMBO journal 1990;9(5):1603-14.
1990: Jean-Marc Jeltsch; B Turcotte; Jean-Marie Garnier; Thierry Lerouge; Z Krozowski; Hinrich Gronemeyer; Pierre Chambon
Characterization of multiple mRNAs originating from the chicken progesterone receptor gene. Evidence for a specific transcript encoding form A.
The Journal of biological chemistry 1990;265(7):3967-74.
1989: M E Meyer; Hinrich Gronemeyer; B Turcotte; M T Bocquel; D Tasset; Pierre Chambon
Steroid hormone receptors compete for factors that mediate their enhancer function.
Cell 1989;57(3):433-42.
1989: M T Bocquel; V Kumar; C Stricker; Pierre Chambon; Hinrich Gronemeyer
The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific.
Nucleic acids research 1989;17(7):2581-95.
1989: J Eul; M E Meyer; Làszlò Tora; M T Bocquel; C Quirin-Stricker; Pierre Chambon; Hinrich Gronemeyer
Expression of active hormone and DNA-binding domains of the chicken progesterone receptor in E. coli.
The EMBO journal 1989;8(1):83-90.
1988: Làszlò Tora; Hinrich Gronemeyer; B Turcotte; M P Gaub; Pierre Chambon
The N-terminal region of the chicken progesterone receptor specifies target gene activation.
Nature 1988;333(6169):185-8.
1988: J Eul; Hinrich Gronemeyer; S Adolph; Horst Hameister
Suppression of tumorigenicity in T-cell lymphoma hybrids is correlated with changes in myc expression and DNA replication of the myc chromosomal domain.
Chromosoma 1988;96(3):248-54.
1987: Hinrich Gronemeyer; B Turcotte; C Quirin-Stricker; M T Bocquel; M E Meyer; Z Krozowski; Jean-Marc Jeltsch; Thierry Lerouge; Jean-Marie Garnier; Pierre Chambon
The chicken progesterone receptor: sequence, expression and functional analysis.
The EMBO journal 1987;6(13):3985-94.
1987: Richard J Simpson; B Grego; M V Govindan; Hinrich Gronemeyer
Peptide sequencing of the chick oviduct progesterone receptor form B.
Molecular and cellular endocrinology 1987;52(3):177-84.
1986: Jean-Marc Jeltsch; Z Krozowski; C Quirin-Stricker; Hinrich Gronemeyer; R J Simpson; Jean-Marie Garnier; A Krust; F Jacob; Pierre Chambon
Cloning of the chicken progesterone receptor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5424-8.
1986: Hinrich Gronemeyer; M V Govindan
Affinity labelling of steroid hormone receptors.
Molecular and cellular endocrinology 1986;46(1):1-19.
1985: M V Govindan; M Devic; S Green; Hinrich Gronemeyer; P Chambon
Cloning of the human glucocorticoid receptor cDNA.
Nucleic acids research 1985;13(23):8293-304.
1985: Hinrich Gronemeyer; M V Govindan; P Chambon
Immunological similarity between the chick oviduct progesterone receptor forms A and B.
The Journal of biological chemistry 1985;260(11):6916-25.
1984: M V Govindan; Hinrich Gronemeyer
Characterization of the rat liver glucocorticoid receptor purified by DNA-cellulose and ligand affinity chromatography.
The Journal of biological chemistry 1984;259(20):12915-24.
1983: Hinrich Gronemeyer; P Harry; A Alberga
A reappraisal of ecdysteroid binding in Drosophila.
Molecular and cellular endocrinology 1983;32(2-3):171-8.
1983: Hinrich Gronemeyer; P Harry; P Chambon
Evidence for two structurally related progesterone receptors in chick oviduct cytosol.
FEBS letters 1983;156(2):287-92.
1981: Hinrich Gronemeyer; H Hameister; O Pongs
Photoinduced bonding of endogenous ecdysterone to salivary gland chromosomes of Chironomus tentans.
Chromosoma 1981;82(4):543-59.
1980: Hinrich Gronemeyer; O Pongs
Localization of ecdysterone on polytene chromosomes of Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2108-12.