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Hinrich Gronemeyer
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46
Chambon, Pierre
20
de Lera, Angel
18
Altucci, Lucia
16
Bourguet, William
16
Germain, Pierre
15
Moras, Dino
13
Vivat Hannah, Valerie
8
Rossin, Aurélie
7
Wurtz, Jean-Marie
6
Tora, Làszlò
6
Nebbioso, Angela
6
Lerouge, Thierry
6
Losson, Régine
6
Garnier, Jean-Marie
6
Clarke, Nicole
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All Publications
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2009: Tacke Reinhold; Müller Volker; Büttner Matthias W; Lippert W Peter; Bertermann Rüdiger; Daiss Jürgen O; Khanwalkar Harshal; Furst Audrey; Gaudon Claudine; Gronemeyer Hinrich
Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.
ChemMedChem 2009;4(11):1797-802.
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2009: Alvarez Susana; Khanwalkar Harshal; Alvarez Rosana; Erb Cathie; Martínez Claudio; Rodríguez-Barrios Fátima; Germain Pierre; Gronemeyer Hinrich; de Lera Angel R
C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function.
ChemMedChem 2009;4(10):1630-40.
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2009: Shankaranarayanan Pattabhiraman; Rossin Aurélie; Khanwalkar Harshal; Alvarez Susana; Alvarez Rosana; Jacobson Annica; Nebbioso Angela; de Lera Angel R; Altucci Lucia; Gronemeyer Hinrich
Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.
Cancer cell 2009;16(3):220-31.
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2009: Galluzzi L; Aaronson S A; Abrams J; Alnemri E S; Andrews D W; Baehrecke E H; Bazan N G; Blagosklonny M V; Blomgren K; Borner C; Bredesen D E; Brenner C; Castedo M; Cidlowski J A; Ciechanover A; Cohen G M; De Laurenzi V; De Maria R; Deshmukh M; Dynlacht B D; El-Deiry W S; Flavell R A; Fulda S; Garrido C; Golstein P; Gougeon M-L; Green D R; Gronemeyer H; Hajnóczky G; Hardwick J M; Hengartner M O; Ichijo H; Jäättelä M; Kepp O; Kimchi A; Klionsky D J; Knight R A; Kornbluth S; Kumar S; Levine B; Lipton S A; Lugli E; Madeo F; Malomi W; Marine J-C W; Martin S J; Medema J P; Mehlen P; Melino G; Moll U M; Morselli E; Nagata S; Nicholson D W; Nicotera P; Nuñez G; Oren M; Penninger J; Pervaiz S; Peter M E; Piacentini M; Prehn J H M; Puthalakath H; Rabinovich G A; Rizzuto R; Rodrigues C M P; Rubinsztein D C; Rudel T; Scorrano L; Simon H-U; Steller H; Tschopp J; Tsujimoto Y; Vandenabeele P; Vitale I; Vousden K H; Youle R J; Yuan J; Zhivotovsky B; Kroemer G
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell death and differentiation 2009;16(8):1093-107.
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2009: Nebbioso Angela; Manzo Fabio; Miceli Marco; Conte Mariarosaria; Manente Lucrezia; Baldi Alfonso; De Luca Antonio; Rotili Dante; Valente Sergio; Mai Antonello; Usiello Alessandro; Gronemeyer Hinrich; Altucci Lucia
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes.
EMBO reports 2009;10(7):776-82.
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2009: Lippert W Peter; Burschka Christian; Götz Kathrin; Kaupp Martin; Ivanova Diana; Gaudon Claudine; Sato Yoshiteru; Antony Pierre; Rochel Natacha; Moras Dino; Gronemeyer Hinrich; Tacke Reinhold
Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology.
ChemMedChem 2009;4(7):1143-52.
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2009: Alvarez Susana; Alvarez Rosana; Khanwalkar Harshal; Germain Pierre; Lemaire Géraldine; Rodríguez-Barrios Fátima; Gronemeyer Hinrich; de Lera Angel R
Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.
Bioorganic & medicinal chemistry 2009;17(13):4345-59.
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2009: Germain Pierre; Gaudon Claudine; Pogenberg Vivian; Sanglier Sarah; Van Dorsselaer Alain; Royer Catherine A; Lazar Mitchell A; Bourguet William; Gronemeyer Hinrich
Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists.
Chemistry & biology 2009;16(5):479-89.
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2009: Pérez Santín Efrén; Germain Pierre; Quillard Fabien; Khanwalkar Harshal; Rodríguez-Barrios Fátima; Gronemeyer Hinrich; de Lera Angel R; Bourguet William
Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers.
Journal of medicinal chemistry 2009;52(10):3150-8.
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2009: Santín Efrén Pérez; Khanwalkar Harshal; Voegel Johannes; Collette Pascal; Mauvais Pascale; Gronemeyer Hinrich; de Lera Angel R
Highly potent naphthofuran-based retinoic acid receptor agonists.
ChemMedChem 2009;4(5):780-91.
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2009: García José; Khanwalkar Harshal; Pereira Raquel; Erb Cathie; Voegel Johannes J; Collette Pascal; Mauvais Pascale; Bourguet William; Gronemeyer Hinrich; de Lera Angel R
Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors.
Chembiochem : a European journal of chemical biology 2009;10(7):1252-9.
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2009: Gronemeyer Hinrich; Zelent Arthur
Fingering modulators of retinoic acid signaling identifies new prognostic marker for neuroblastoma.
Cancer cell 2009;15(4):249-51.
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2009: Gronemeyer Hinrich; Bourguet William
Allosteric effects govern nuclear receptor action: DNA appears as a player.
Science signaling 2009;2(73):pe34.
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2008: Alvarez Susana; Pazos-Randulfe Yolanda; Khanwalkar Harshal; Germain Pierre; Alvarez Rosana; Gronemeyer Hinrich; de Lera Angel R
New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists.
Bioorganic & medicinal chemistry 2008;16(22):9719-28.
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2008: Caselli Elisabetta; Galvan Monica; Santoni Fabio; Alvarez Susana; de Lera Angel R; Ivanova Diana; Gronemeyer Hinrich; Caruso Arnaldo; Guidoboni Massimo; Cassai Enzo; Dolcetti Riccardo; Di Luca Dario
Retinoic acid analogues inhibit human herpesvirus 8 replication.
Antiviral therapy 2008;13(2):199-209.
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2008: Voltz Emilie; Gronemeyer Hinrich
A new era of cancer therapy: cancer cell targeted therapies are coming of age.
The international journal of biochemistry & cell biology 2008;40(1):1-8.
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2007: Epping Mirjam T; Wang Liming; Plumb Jane A; Lieb Michele; Gronemeyer Hinrich; Brown Robert; Bernards René
A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17777-82.
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2007: Nahoum Virginie; Pérez Efrén; Germain Pierre; Rodríguez-Barrios Fátima; Manzo Fabio; Kammerer Sabrina; Lemaire Geraldine; Hirsch Oliver; Royer Catherine A; Gronemeyer Hinrich; de Lera Angel R; Bourguet William
Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17323-8.
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2007: de Lera Angel R; Bourguet William; Altucci Lucia; Gronemeyer Hinrich
Design of selective nuclear receptor modulators: RAR and RXR as a case study.
Nature reviews. Drug discovery 2007;6(10):811-20.
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2007: Altucci Lucia; Leibowitz Mark D; Ogilvie Kathleen M; de Lera Angel R; Gronemeyer Hinrich
RAR and RXR modulation in cancer and metabolic disease.
Nature reviews. Drug discovery 2007;6(10):793-810.
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2007: Büttner Matthias W; Burschka Christian; Daiss Jürgen O; Ivanova Diana; Rochel Natacha; Kammerer Sabrina; Peluso-Iltis Carole; Bindler Audrey; Gaudon Claudine; Germain Pierre; Moras Dino; Gronemeyer Hinrich; Tacke Reinhold
Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology.
Chembiochem : a European journal of chemical biology 2007;8(14):1688-99.
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2007: Zeisig Bernd B; Kwok Colin; Zelent Arthur; Shankaranarayanan Pattabhiraman; Gronemeyer Hinrich; Dong Shuo; So Chi Wai Eric
Recruitment of RXR by homotetrameric RARalpha fusion proteins is essential for transformation.
Cancer cell 2007;12(1):36-51.
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2007: Tsapis Michael; Lieb Michèle; Manzo Fabio; Shankaranarayanan Pattabhiraman; Herbrecht Raoul; Lutz Patrick; Gronemeyer Hinrich
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
The international journal of biochemistry & cell biology 2007;39(7-8):1500-9.
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2007: Alvarez Susana; Germain Pierre; Alvarez Rosana; Rodríguez-Barrios Fátima; Gronemeyer Hinrich; de Lera Angel R
Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor.
The international journal of biochemistry & cell biology 2007;39(7-8):1406-15.
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2006: Pereira Raquel; Furst Audrey; Iglesias Beatriz; Germain Pierre; Gronemeyer Hinrich; de Lera Angel R
Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARbeta/delta agonists.
Organic & biomolecular chemistry 2006;4(24):4514-25.
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2006: Germain Pierre; Chambon Pierre; Eichele Gregor; Evans Ronald M; Lazar Mitchell A; Leid Mark; De Lera Angel R; Lotan Reuben; Mangelsdorf David J; Gronemeyer Hinrich
International Union of Pharmacology. LXIII. Retinoid X receptors.
Pharmacological reviews 2006;58(4):760-72.
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2006: Germain Pierre; Chambon Pierre; Eichele Gregor; Evans Ronald M; Lazar Mitchell A; Leid Mark; De Lera Angel R; Lotan Reuben; Mangelsdorf David J; Gronemeyer Hinrich
International Union of Pharmacology. LX. Retinoic acid receptors.
Pharmacological reviews 2006;58(4):712-25.
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2006: Escriva Hector; Bertrand Stéphanie; Germain Pierre; Robinson-Rechavi Marc; Umbhauer Muriel; Cartry Jérôme; Duffraisse Marilyne; Holland Linda; Gronemeyer Hinrich; Laudet Vincent
Neofunctionalization in vertebrates: the example of retinoic acid receptors.
PLoS genetics 2006;2(7):e102.
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2006: Nagy Laszlo; Schüle Roland; Gronemeyer Hinrich
Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease.
EMBO reports 2006;7(6):579-84.
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2006: Yin W; Rossin A; Clifford J L; Gronemeyer H
Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.
Oncogene 2006;25(26):3735-44.
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2006: Obradovic Darja; Gronemeyer Hinrich; Lutz Beat; Rein Theo
Cross-talk of vitamin D and glucocorticoids in hippocampal cells.
Journal of neurochemistry 2006;96(2):500-9.
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2006: Pereira Raquel; Gaudon Claudine; Iglesias Beatriz; Germain Pierre; Gronemeyer Hinrich; de Lera Angel R
Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.
Bioorganic & medicinal chemistry letters 2006;16(1):49-54.
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2005: Lou Yan-Ru; Miettinen Susanna; Kagechika Hiroyuki; Gronemeyer Hinrich; Tuohimaa Pentti
Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells.
Biochemical and biophysical research communications 2005;338(4):1973-81.
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2005: Altucci Lucia; Rossin Aurélie; Hirsch Oliver; Nebbioso Angela; Vitoux Dominique; Wilhelm Emmanuelle; Guidez Fabien; De Simone Mariacarla; Schiavone Ettore Mariano; Grimwade David; Zelent Arthur; de Thé Hugues; Gronemeyer Hinrich
Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor.
Cancer research 2005;65(19):8754-65.
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2005: Altucci Lucia; Clarke Nicole; Nebbioso Angela; Scognamiglio Annamaria; Gronemeyer Hinrich
Acute myeloid leukemia: therapeutic impact of epigenetic drugs.
The international journal of biochemistry & cell biology 2005;37(9):1752-62.
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2005: Yin Weihong; Raffelsberger Wolfgang; Gronemeyer Hinrich
Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs.
The international journal of biochemistry & cell biology 2005;37(8):1696-708.
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2005: Clarke Nicole; Nebbioso Angela; Altucci Lucia; Gronemeyer Hinrich
TRAIL: at the center of drugable anti-tumor pathways.
Cell cycle (Georgetown, Tex.) 2005;4(7):914-8.
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2005: Nebbioso Angela; Clarke Nicole; Voltz Emilie; Germain Emmanuelle; Ambrosino Concetta; Bontempo Paola; Alvarez Rosana; Schiavone Ettore M; Ferrara Felicetto; Bresciani Francesco; Weisz Alessandro; de Lera Angel R; Gronemeyer Hinrich; Altucci Lucia
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells.
Nature medicine 2005;11(1):77-84.
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2005: Pogenberg Vivian; Guichou Jean-François; Vivat-Hannah Valérie; Kammerer Sabrina; Pérez Efrén; Germain Pierre; de Lera Angel R; Gronemeyer Hinrich; Royer Catherine A; Bourguet William
Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.
The Journal of biological chemistry 2005;280(2):1625-33.
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2004: Sanglier Sarah; Bourguet William; Germain Pierre; Chavant Virginie; Moras Dino; Gronemeyer Hinrich; Potier Noelle; Van Dorsselaer Alain
Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry.
European journal of biochemistry / FEBS 2004;271(23-24):4958-67.
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2004: Alvarez Rosana; Vega M Jesús; Kammerer Sabrina; Rossin Aurélie; Germain Pierre; Gronemeyer Hinrich; de Lera Angel R
9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists.
Bioorganic & medicinal chemistry letters 2004;14(24):6117-22.
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2004: Clarke Nicole; Germain Pierre; Altucci Lucia; Gronemeyer Hinrich
Retinoids: potential in cancer prevention and therapy.
Expert reviews in molecular medicine 2004;6(25):1-23.
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2004: Gronemeyer Hinrich; Gustafsson Jan-Ake; Laudet Vincent
Principles for modulation of the nuclear receptor superfamily.
Nature reviews. Drug discovery 2004;3(11):950-64.
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2004: Kammerer Sabrina; Germain Pierre; Flaig Ralf; Peluso-Iltis Carole; Mitschler André; Rochel Natacha; Gronemeyer Hinrich; Moras Dino
RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 11):2048-50.
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2004: Jiménez-Lara A M; Clarke N; Altucci L; Gronemeyer H
Retinoic-acid-induced apoptosis in leukemia cells.
Trends in molecular medicine 2004;10(10):508-15.
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2004: Germain Pierre; Kammerer Sabrina; Pérez Efrén; Peluso-Iltis Carole; Tortolani David; Zusi F Christopher; Starrett John; Lapointe Philippe; Daris Jean-Paul; Marinier Anne; de Lera Angel R; Rochel Natacha; Gronemeyer Hinrich
Rational design of RAR-selective ligands revealed by RARbeta crystal stucture.
EMBO reports 2004;5(9):877-82.
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2004: Ivanova Diana; Rossin Aurélie; Gronemeyer Hinrich; Valla Alain; Cartier Dominique; Le Guillou Régis; Labia Roger
Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells.
Bioorganic & medicinal chemistry letters 2004;14(16):4257-61.
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2004: Clarke Nicole; Jimenez-Lara Ana M; Voltz Emilie; Gronemeyer Hinrich
Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL.
The EMBO journal 2004;23(15):3051-60.
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2004: Obradovic D; Tirard M; Némethy Zs; Hirsch O; Gronemeyer H; Almeida O F X
DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors?
Molecular pharmacology 2004;65(3):761-9.
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2004: Altucci Lucia; Wilhelm Emmanuelle; Gronemeyer Hinrich
Leukemia: beneficial actions of retinoids and rexinoids.
The international journal of biochemistry & cell biology 2004;36(2):178-82.
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2004: Altucci Lucia; Gronemeyer Hinrich
Retinoids and TRAIL: two cooperating actors to fight against cancer.
Vitamins and hormones 2004;67():319-45.
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2003: Vivat-Hannah Valerie; Bourguet William; Gottardis Marco; Gronemeyer Hinrich
Separation of retinoid X receptor homo- and heterodimerization functions.
Molecular and cellular biology 2003;23(21):7678-88.
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2002: Raffelsberger Wolfgang; Dembélé Doulaye; Neubauer Mike G; Gottardis Marco M; Gronemeyer Hinrich
Quality indicators increase the reliability of microarray data.
Genomics 2002;80(4):385-94.
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2002: Bommer Martin; Benecke Arndt; Gronemeyer Hinrich; Rochette-Egly Cécile
TIF2 mediates the synergy between RARalpha 1 activation functions AF-1 and AF-2.
The Journal of biological chemistry 2002;277(40):37961-6.
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2002: Jiménez-Lara Ana M; Heine Mattias J S; Gronemeyer Hinrich
PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2.
FEBS letters 2002;526(1-3):142-6.
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2002: Gehin Martine; Mark Manuel; Dennefeld Christine; Dierich Andrée; Gronemeyer Hinrich; Chambon Pierre
The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.
Molecular and cellular biology 2002;22(16):5923-37.
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2002: Ivanova D; Gaudon C; Rossin A; Bourguet W; Gronemeyer H
RAR-RXR selectivity and biological activity of new retinoic acid analogues with heterocyclic or polycyclic aromatic systems.
Bioorganic & medicinal chemistry 2002;10(7):2099-102.
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2002: Escriva Hector; Holland Nicholas D; Gronemeyer Hinrich; Laudet Vincent; Holland Linda Z
The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest.
Development (Cambridge, England) 2002;129(12):2905-16.
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2002: Altucci Lucia; Gronemeyer Hinrich
Decryption of the retinoid death code in leukemia.
Journal of clinical immunology 2002;22(3):117-23.
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2002: Germain Pierre; Iyer Jaya; Zechel Christina; Gronemeyer Hinrich
Co-regulator recruitment and the mechanism of retinoic acid receptor synergy.
Nature 2002;415(6868):187-92.
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2001: Altucci L; Gronemeyer H
The promise of retinoids to fight against cancer.
Nature reviews. Cancer 2001;1(3):181-93.
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2001: Altucci L; Gronemeyer H
Nuclear receptors in cell life and death.
Trends in endocrinology and metabolism: TEM 2001;12(10):460-8.
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2001: Benoit G R; Flexor M; Besançon F; Altucci L; Rossin A; Hillion J; Balajthy Z; Legres L; Ségal-Bendirdjian E; Gronemeyer H; Lanotte M
Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells.
Molecular endocrinology (Baltimore, Md.) 2001;15(7):1154-69.
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2001: Altucci L; Rossin A; Raffelsberger W; Reitmair A; Chomienne C; Gronemeyer H
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.
Nature medicine 2001;7(6):680-6.
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2001: Gronemeyer H; Miturski R
Molecular mechanisms of retinoid action.
Cellular & molecular biology letters 2001;6(1):3-52.
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2000: Bourguet W; Germain P; Gronemeyer H
Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications.
Trends in pharmacological sciences 2000;21(10):381-8.
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2000: Benecke A; Chambon P; Gronemeyer H
Synergy between estrogen receptor alpha activation functions AF1 and AF2 mediated by transcription intermediary factor TIF2.
EMBO reports 2000;1(2):151-7.
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2000: Bourguet W; Andry V; Iltis C; Klaholz B; Potier N; Van Dorsselaer A; Chambon P; Gronemeyer H; Moras D
Heterodimeric complex of RAR and RXR nuclear receptor ligand-binding domains: purification, crystallization, and preliminary X-ray diffraction analysis.
Protein expression and purification 2000;19(2):284-8.
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2000: Bourguet W; Vivat V; Wurtz J M; Chambon P; Gronemeyer H; Moras D
Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains.
Molecular cell 2000;5(2):289-98.
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2000: Jimenez-Lara A M; Heine M J; Gronemeyer H
Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family.
FEBS letters 2000;468(2-3):203-10.
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1999: Ebisawa M; Umemiya H; Ohta K; Fukasawa H; Kawachi E; Christoffel G; Gronemeyer H; Tsuji M; Hashimoto Y; Shudo K; Kagechika H
Retinoid X receptor-antagonistic diazepinylbenzoic acids.
Chemical & pharmaceutical bulletin 1999;47(12):1778-86.
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1999: He B; Kemppainen J A; Voegel J J; Gronemeyer H; Wilson E M
Activation function 2 in the human androgen receptor ligand binding domain mediates interdomain communication with the NH(2)-terminal domain.
The Journal of biological chemistry 1999;274(52):37219-25.
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1999: Benoit G; Altucci L; Flexor M; Ruchaud S; Lillehaug J; Raffelsberger W; Gronemeyer H; Lanotte M
RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.
The EMBO journal 1999;18(24):7011-8.
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1999: Gronemeyer H
Structure and function of nuclear receptors--EMBO workshop. 25-27 May 1999, Villefranche-sur-Mer, Nice, France.
IDrugs : the investigational drugs journal 1999;2(8):760-2.
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1999: Géhin M; Vivat V; Wurtz J M; Losson R; Chambon P; Moras D; Gronemeyer H
Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists.
Chemistry & biology 1999;6(8):519-29.
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1999: Iyer J; Bonnier D; Granger F; Iltis C; Andry V; Schultz P; Gronemeyer H
Versatile copurification procedure for rapid isolation of homogeneous RAR-RXR heterodimers.
Protein expression and purification 1999;16(2):308-14.
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1998: Gronemeyer H
Receptor mechanisms: Principles of agonism.
IDrugs : the investigational drugs journal 1998;1(6):657-9.
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1998: Resche-Rigon M; Gronemeyer H
Therapeutic potential of selective modulators of nuclear receptor action.
Current opinion in chemical biology 1998;2(4):501-7.
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1998: Moras D; Gronemeyer H
The nuclear receptor ligand-binding domain: structure and function.
Current opinion in cell biology 1998;10(3):384-91.
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1998: Klaholz B P; Renaud J P; Mitschler A; Zusi C; Chambon P; Gronemeyer H; Moras D
Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nature structural biology 1998;5(3):199-202.
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1998: Chen Z P; Iyer J; Bourguet W; Held P; Mioskowski C; Lebeau L; Noy N; Chambon P; Gronemeyer H
Ligand- and DNA-induced dissociation of RXR tetramers.
Journal of molecular biology 1998;275(1):55-65.
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1998: Voegel J J; Heine M J; Tini M; Vivat V; Chambon P; Gronemeyer H
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
The EMBO journal 1998;17(2):507-19.
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1998: Ylikomi T; Wurtz J M; Syvälä H; Passinen S; Pekki A; Haverinen M; Bläuer M; Tuohimaa P; Gronemeyer H
Reappraisal of the role of heat shock proteins as regulators of steroid receptor activity.
Critical reviews in biochemistry and molecular biology 1998;33(6):437-66.
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1998: Morjani H; Beljebbar A; Sockalingum G D; Mattioli T A; Bonnier D; Gronemeyer H; Manfait M
Surface-enhanced Raman scattering and fluorescence spectroscopy reveal molecular interactions of all-trans retinoic acid and RAR gamma ligand-binding domain.
Biospectroscopy 1998;4(5):297-302.
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1997: Umemiya H; Fukasawa H; Ebisawa M; Eyrolles L; Kawachi E; Eisenmann G; Gronemeyer H; Hashimoto Y; Shudo K; Kagechika H
Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.
Journal of medicinal chemistry 1997;40(26):4222-34.
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1997: Vivat V; Zechel C; Wurtz J M; Bourguet W; Kagechika H; Umemiya H; Shudo K; Moras D; Gronemeyer H; Chambon P
A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers.
The EMBO journal 1997;16(18):5697-709.
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1997: Vayssière B M; Dupont S; Choquart A; Petit F; Garcia T; Marchandeau C; Gronemeyer H; Resche-Rigon M
Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo.
Molecular endocrinology (Baltimore, Md.) 1997;11(9):1245-55.
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1997: Kersten S; Gronemeyer H; Noy N
The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state.
The Journal of biological chemistry 1997;272(19):12771-7.
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1997: Umemiya H; Kagechika H; Fukasawa H; Kawachi E; Ebisawa M; Hashimoto Y; Eisenmann G; Erb C; Pornon A; Chambon P; Gronemeyer H; Shudo K
Action mechanism of retinoid-synergistic dibenzodiazepines.
Biochemical and biophysical research communications 1997;233(1):121-5.
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1997: Vivat V; Gofflo D; Garcia T; Wurtz J M; Bourguet W; Philibert D; Gronemeyer H
Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities.
Journal of molecular endocrinology 1997;18(2):147-60.
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1997: Rochel N; Renaud J P; Ruff M; Vivat V; Granger F; Bonnier D; Lerouge T; Chambon P; Gronemeyer H; Moras D
Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.
Biochemical and biophysical research communications 1997;230(2):293-6.
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1996: Roux S; Térouanne B; Balaguer P; Jausons-Loffreda N; Pons M; Chambon P; Gronemeyer H; Nicolas J C
Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 1996;10(10):1214-26.
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1996: Gérard M; Chen J Y; Gronemeyer H; Chambon P; Duboule D; Zákány J
In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries.
Genes & development 1996;10(18):2326-34.
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1996: Chen J Y; Clifford J; Zusi C; Starrett J; Tortolani D; Ostrowski J; Reczek P R; Chambon P; Gronemeyer H
Two distinct actions of retinoid-receptor ligands.
Nature 1996;382(6594):819-22.
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1996: Voegel J J; Heine M J; Zechel C; Chambon P; Gronemeyer H
TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.
The EMBO journal 1996;15(14):3667-75.
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1996: Le Douarin B; vom Baur E; Zechel C; Heery D; Heine M; Vivat V; Gronemeyer H; Losson R; Chambon P
Ligand-dependent interaction of nuclear receptors with potential transcriptional intermediary factors (mediators).
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1339):569-78.
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1996: Wurtz J M; Bourguet W; Renaud J P; Vivat V; Chambon P; Moras D; Gronemeyer H
A canonical structure for the ligand-binding domain of nuclear receptors.
Nature structural biology 1996;3(2):206.
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1996: vom Baur E; Zechel C; Heery D; Heine M J; Garnier J M; Vivat V; Le Douarin B; Gronemeyer H; Chambon P; Losson R
Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
The EMBO journal 1996;15(1):110-24.
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1996: Wurtz J M; Bourguet W; Renaud J P; Vivat V; Chambon P; Moras D; Gronemeyer H
A canonical structure for the ligand-binding domain of nuclear receptors.
Nature structural biology 1996;3(1):87-94.
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1995: Renaud J P; Rochel N; Ruff M; Vivat V; Chambon P; Gronemeyer H; Moras D
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
Nature 1995;378(6558):681-9.
-
1995: Kato S; Sasaki H; Suzawa M; Masushige S; Tora L; Chambon P; Gronemeyer H
Widely spaced, directly repeated PuGGTCA elements act as promiscuous enhancers for different classes of nuclear receptors.
Molecular and cellular biology 1995;15(11):5858-67.
-
1995: Bourguet W; Ruff M; Bonnier D; Granger F; Boeglin M; Chambon P; Moras D; Gronemeyer H
Purification, functional characterization, and crystallization of the ligand binding domain of the retinoid X receptor.
Protein expression and purification 1995;6(5):604-8.
-
1995: Kersten S; Pan L; Chambon P; Gronemeyer H; Noy N
Role of ligand in retinoid signaling. 9-cis-retinoic acid modulates the oligomeric state of the retinoid X receptor.
Biochemistry 1995;34(42):13717-21.
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1995: Kersten S; Kelleher D; Chambon P; Gronemeyer H; Noy N
Retinoid X receptor alpha forms tetramers in solution.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8645-9.
-
1995: Bourguet W; Ruff M; Chambon P; Gronemeyer H; Moras D
Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha.
Nature 1995;375(6530):377-82.
-
1995: Gronemeyer H; Moras D
Nuclear receptors. How to finger DNA.
Nature 1995;375(6528):190-1.
-
1995: Le Douarin B; Zechel C; Garnier J M; Lutz Y; Tora L; Pierrat P; Heery D; Gronemeyer H; Chambon P; Losson R
The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
The EMBO journal 1995;14(9):2020-33.
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1995: Chen J Y; Penco S; Ostrowski J; Balaguer P; Pons M; Starrett J E; Reczek P; Chambon P; Gronemeyer H
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
The EMBO journal 1995;14(6):1187-97.
-
1995: Gronemeyer H; Laudet V
Transcription factors 3: nuclear receptors.
Protein profile 1995;2(11):1173-308.
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1994: Chen Z P; Shemshedini L; Durand B; Noy N; Chambon P; Gronemeyer H
Pure and functionally homogeneous recombinant retinoid X receptor.
The Journal of biological chemistry 1994;269(41):25770-6.
-
1994: Heery D M; Pierrat B; Gronemeyer H; Chambon P; Losson R
Homo- and heterodimers of the retinoid X receptor (RXR) activated transcription in yeast.
Nucleic acids research 1994;22(5):726-31.
-
1994: Zechel C; Shen X Q; Chen J Y; Chen Z P; Chambon P; Gronemeyer H
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
The EMBO journal 1994;13(6):1425-33.
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1994: Zechel C; Shen X Q; Chambon P; Gronemeyer H
Dimerization interfaces formed between the DNA binding domains determine the cooperative binding of RXR/RAR and RXR/TR heterodimers to DR5 and DR4 elements.
The EMBO journal 1994;13(6):1414-24.
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1993: Mader S; Chen J Y; Chen Z; White J; Chambon P; Gronemeyer H
The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains.
The EMBO journal 1993;12(13):5029-41.
-
1993: Rudert F; Gronemeyer H
Retinoic acid-response elements with a highly repetitive structure isolated by immuno-selection from genomic DNA.
The Journal of steroid biochemistry and molecular biology 1993;46(2):121-33.
-
1993: Heery D M; Zacharewski T; Pierrat B; Gronemeyer H; Chambon P; Losson R
Efficient transactivation by retinoic acid receptors in yeast requires retinoid X receptors.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4281-5.
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1993: Bocquel M T; Ji J; Ylikomi T; Benhamou B; Vergezac A; Chambon P; Gronemeyer H
Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization.
The Journal of steroid biochemistry and molecular biology 1993;45(4):205-15.
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1993: Gronemeyer H
Transcription activation by nuclear receptors.
Journal of receptor research 1993;13(1-4):667-91.
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1992: Garcia T; Benhamou B; Gofflo D; Vergezac A; Philibert D; Chambon P; Gronemeyer H
Switching agonistic, antagonistic, and mixed transcriptional responses to 11 beta-substituted progestins by mutation of the progesterone receptor.
Molecular endocrinology (Baltimore, Md.) 1992;6(12):2071-8.
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1992: Reddy A P; Chen J Y; Zacharewski T; Gronemeyer H; Voorhees J J; Fisher G J
Characterization and purification of human retinoic acid receptor-gamma 1 overexpressed in the baculovirus-insect cell system.
The Biochemical journal 1992;287 ( Pt 3)():833-40.
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1992: Ylikomi T; Bocquel M T; Berry M; Gronemeyer H; Chambon P
Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.
The EMBO journal 1992;11(10):3681-94.
-
1992: Gronemeyer H
Control of transcription activation by steroid hormone receptors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(8):2524-9.
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1992: Meyer M E; Quirin-Stricker C; Lerouge T; Bocquel M T; Gronemeyer H
A limiting factor mediates the differential activation of promoters by the human progesterone receptor isoforms.
The Journal of biological chemistry 1992;267(15):10882-7.
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1992: Gronemeyer H; Benhamou B; Berry M; Bocquel M T; Gofflo D; Garcia T; Lerouge T; Metzger D; Meyer M E; Tora L
Mechanisms of antihormone action.
The Journal of steroid biochemistry and molecular biology 1992;41(3-8):217-21.
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1992: Shemshedini L; Ji J W; Brou C; Chambon P; Gronemeyer H
In vitro activity of the transcription activation functions of the progesterone receptor. Evidence for intermediary factors.
The Journal of biological chemistry 1992;267(3):1834-9.
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1992: Benhamou B; Garcia T; Lerouge T; Vergezac A; Gofflo D; Bigogne C; Chambon P; Gronemeyer H
A single amino acid that determines the sensitivity of progesterone receptors to RU486.
Science (New York, N.Y.) 1992;255(5041):206-9.
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1991: Shemshedini L; Knauthe R; Sassone-Corsi P; Pornon A; Gronemeyer H
Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.
The EMBO journal 1991;10(12):3839-49.
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1991: Turcotte B; Meyer M E; Bellard M; Dretzen G; Gronemeyer H; Chambon P
Control of transcription of the chicken progesterone receptor gene. In vitro and in vivo studies.
The Journal of biological chemistry 1991;266(4):2582-9.
-
1991: Gronemeyer H; Meyer M E; Bocquel M T; Kastner P; Turcotte B; Chambon P
Progestin receptors: isoforms and antihormone action.
The Journal of steroid biochemistry and molecular biology 1991;40(1-3):271-8.
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1991: Balaguer P; Demirpence E; Pons M; Gagne D; Bocquel M T; Gronemeyer H; Nicolas J C
[Retinoic acid has an antiestrogenic effect on different regulated estrogen genes in different cellular types]
Comptes rendus des séances de la Société de biologie et de ses filiales 1991;185(6):434-43.
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1991: Gronemeyer H; Meyer M E
[Nuclear receptors. Hormones, anti-hormones and regulation of the transcription]
Annales d'endocrinologie 1991;52(5):335-8.
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1991: Gronemeyer H
Transcription activation by estrogen and progesterone receptors.
Annual review of genetics 1991;25():89-123.
-
1990: Meyer M E; Pornon A; Ji J W; Bocquel M T; Chambon P; Gronemeyer H
Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.
The EMBO journal 1990;9(12):3923-32.
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1990: Kastner P; Bocquel M T; Turcotte B; Garnier J M; Horwitz K B; Chambon P; Gronemeyer H
Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.
The Journal of biological chemistry 1990;265(21):12163-7.
-
1990: Kastner P; Krust A; Turcotte B; Stropp U; Tora L; Gronemeyer H; Chambon P
Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.
The EMBO journal 1990;9(5):1603-14.
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1990: Jeltsch J M; Turcotte B; Garnier J M; Lerouge T; Krozowski Z; Gronemeyer H; Chambon P
Characterization of multiple mRNAs originating from the chicken progesterone receptor gene. Evidence for a specific transcript encoding form A.
The Journal of biological chemistry 1990;265(7):3967-74.
-
1989: Meyer M E; Gronemeyer H; Turcotte B; Bocquel M T; Tasset D; Chambon P
Steroid hormone receptors compete for factors that mediate their enhancer function.
Cell 1989;57(3):433-42.
-
1989: Bocquel M T; Kumar V; Stricker C; Chambon P; Gronemeyer H
The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific.
Nucleic acids research 1989;17(7):2581-95.
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1989: Eul J; Meyer M E; Tora L; Bocquel M T; Quirin-Stricker C; Chambon P; Gronemeyer H
Expression of active hormone and DNA-binding domains of the chicken progesterone receptor in E. coli.
The EMBO journal 1989;8(1):83-90.
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1988: Tora L; Gronemeyer H; Turcotte B; Gaub M P; Chambon P
The N-terminal region of the chicken progesterone receptor specifies target gene activation.
Nature 1988;333(6169):185-8.
-
1988: Eul J; Gronemeyer H; Adolph S; Hameister H
Suppression of tumorigenicity in T-cell lymphoma hybrids is correlated with changes in myc expression and DNA replication of the myc chromosomal domain.
Chromosoma 1988;96(3):248-54.
-
1987: Gronemeyer H; Turcotte B; Quirin-Stricker C; Bocquel M T; Meyer M E; Krozowski Z; Jeltsch J M; Lerouge T; Garnier J M; Chambon P
The chicken progesterone receptor: sequence, expression and functional analysis.
The EMBO journal 1987;6(13):3985-94.
-
1987: Simpson R J; Grego B; Govindan M V; Gronemeyer H
Peptide sequencing of the chick oviduct progesterone receptor form B.
Molecular and cellular endocrinology 1987;52(3):177-84.
-
1986: Jeltsch J M; Krozowski Z; Quirin-Stricker C; Gronemeyer H; Simpson R J; Garnier J M; Krust A; Jacob F; Chambon P
Cloning of the chicken progesterone receptor.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(15):5424-8.
-
1986: Gronemeyer H; Govindan M V
Affinity labelling of steroid hormone receptors.
Molecular and cellular endocrinology 1986;46(1):1-19.
-
1985: Govindan M V; Devic M; Green S; Gronemeyer H; Chambon P
Cloning of the human glucocorticoid receptor cDNA.
Nucleic acids research 1985;13(23):8293-304.
-
1985: Gronemeyer H; Govindan M V; Chambon P
Immunological similarity between the chick oviduct progesterone receptor forms A and B.
The Journal of biological chemistry 1985;260(11):6916-25.
-
1984: Govindan M V; Gronemeyer H
Characterization of the rat liver glucocorticoid receptor purified by DNA-cellulose and ligand affinity chromatography.
The Journal of biological chemistry 1984;259(20):12915-24.
-
1983: Gronemeyer H; Harry P; Alberga A
A reappraisal of ecdysteroid binding in Drosophila.
Molecular and cellular endocrinology 1983;32(2-3):171-8.
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1983: Gronemeyer H; Harry P; Chambon P
Evidence for two structurally related progesterone receptors in chick oviduct cytosol.
FEBS letters 1983;156(2):287-92.
-
1981: Gronemeyer H; Hameister H; Pongs O
Photoinduced bonding of endogenous ecdysterone to salivary gland chromosomes of Chironomus tentans.
Chromosoma 1981;82(4):543-59.
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1980: Gronemeyer H; Pongs O
Localization of ecdysterone on polytene chromosomes of Drosophila melanogaster.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(4):2108-12.
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