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John Cambier

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Lei Jin; Heather M Knowles; Jennifer Mogan; Thomas A Packard; Anne-Laure Perraud; Linda J Akerlund; Andrew Getahun; John C Cambier
STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.
Jill E Slansky; J John Cohen; John C Cambier
Integrated immunology in Colorado.
Thomas A Packard; Russell P Bowler; Gregory P Cosgrove; Quan Z Li; John C Cambier
COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.

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2013: Lei Jin; Heather M Knowles; Jennifer Mogan; Thomas A Packard; Anne-Laure Perraud; Linda J Akerlund; Andrew Getahun; John C Cambier
STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(6):2835-43.
2013: Jill E Slansky; J John Cohen; John C Cambier
Integrated immunology in Colorado.
Immunologic research 2013;55(1-3):1-2.
2013: Thomas A Packard; Russell P Bowler; Gregory P Cosgrove; Quan Z Li; John C Cambier
COPD is associated with production of autoantibodies to a broad spectrum of self-antigens, correlative with disease phenotype.
Immunologic research 2013;55(1-3):48-57.
2012: Eric T Clambey; Sean P Colgan; Edwin F de Zoeten; Louise E Glover; Paul Jedlicka; Eóin N McNamee; Kurt R Stenmark; Joseph A Westrich; John C Cambier; Eric L Campbell; Holger K Eltzschig
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):E2784-93.
2012: Igor Kogut; Jean L Scholz; Michael P Cancro; John C Cambier
B cell maintenance and function in aging.
Seminars in immunology 2012;24(5):342-9.
2012: Andrew Getahun; Igor Kogut; Mia J Smith; Linda F van Dyk; John C Cambier
Retention of anergy and inhibition of antibody responses during acute γ herpesvirus 68 infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(6):2965-74.
2012: Lei Jin; John C Cambier
SMIP-016 in action: CD37 as a death receptor.
Cancer cell 2012;21(5):597-8.
2012: Paul M Waterman; Susanne Marschner; Erin Brandl; John C Cambier
The inositol 5-phosphatase SHIP-1 and adaptors Dok-1 and 2 play central roles in CD4-mediated inhibitory signaling.
Immunology letters 2012;143(1):122-30.
2012: Rebecca L O'Brien; Deming Sun; M Kemal Aydintug; Dawn Bohrer-Kunter; John C Cambier; Jennifer L Chain; Richard Davidson; Ian R Hardy; Yafei Huang; Kevin Lahmers; Tanja Nuhsbaum; Willi K Born
αβ TCR⁺ T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking γδ T cells.
Investigative ophthalmology & visual science 2012;53(1):301-8.
2011: Shannon K O'Neill; Mia J Smith; Idan Tamir; Joseph M Dal Porto; Stephen B Gauld; Andrew Getahun; Quan-Zhen Li; Kevin T Merrell; John C Cambier
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy.
Immunity 2011;35(5):746-56.
2011: Lei Jin; Heather Knowles; John C Cambier; Holly Filak; Krista K Hill; Jennifer Mogan; Anne-Laure Perraud; Bicheng Zhang; Laurel L Lenz
MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2595-601.
2011: Yuval Yarkoni; John C Cambier
Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude.
Molecular immunology 2011;48(15-16):1851-8.
2011: Kara Lukin; Scott Fields; Lisa Guerrettaz; Desiree Straign; Valerie Rodriguez; Sasan Zandi; Robert Månsson; John C Cambier; Mikael Sigvardsson; James Hagman
A dose-dependent role for EBF1 in repressing non-B-cell-specific genes.
European journal of immunology 2011;41(6):1787-93.
2011: L Jin; L-G Xu; I V Yang; E J Davidson; D A Schwartz; M M Wurfel; John C Cambier
Identification and characterization of a loss-of-function human MPYS variant.
Genes and immunity 2011;12(4):263-9.
2010: Paul M Waterman; John C Cambier
The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.
FEBS letters 2010;584(24):4878-82.
2010: Yuval Yarkoni; Andrew Getahun; John C Cambier
Molecular underpinning of B-cell anergy.
Immunological reviews 2010;237(1):249-63.
2010: John C Cambier; Andy Getahun
B cell activation versus anergy; the antigen receptor as a molecular switch.
Immunology letters 2010;128(1):6-7.
2010: Lei Jin; Laurel L Lenz; John C Cambier
Cellular reactive oxygen species inhibit MPYS induction of IFNβ.
PloS one 2010;5(12):e15142.
2009: Leila Jackson; Carol T Cady; John C Cambier
TLR4-mediated signaling induces MMP9-dependent cleavage of B cell surface CD23.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(4):2585-92.
2009: Shannon K O'Neill; Edwin Liu; John C Cambier
Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes.
Current opinion in endocrinology, diabetes, and obesity 2009;16(4):293-8.
2008: Yongmei Li; Fangqi Chen; Mary E Putt; Yumee K Koo; Michael P. Madaio; John C Cambier; Philip L Cohen; Robert A Eisenberg
B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(5):2961-72.
2008: Lisa M Guerrettaz; Sara A Johnson; John C Cambier
Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11898-902.
2008: Carol T Cady; Jeffrey S Rice; Vanessa L Ott; John C Cambier
Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.
Immunological reviews 2008;224():44-57.
2008: Lei Jin; Paul M Waterman; Karen R Jonscher; Cindy M Short; Nichole A Reisdorph; John C Cambier
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals.
Molecular and cellular biology 2008;28(16):5014-26.
2008: Lei Jin; John C Stolpa; Ryan M Young; Aimee E Pugh-Bernard; Yosef Refaeli; John C Cambier
MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death.
Immunology letters 2008;116(2):184-94.
2007: Frank J Conrad; Jeffrey S Rice; John C Cambier
Multiple paths to loss of anergy and gain of autoimmunity.
Autoimmunity 2007;40(6):418-24.
2007: Taras Lyubchenko; Joseph M Dal Porto; V Michael Holers; John C Cambier
Cutting edge: Complement (C3d)-linked antigens break B cell anergy.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):2695-9.
2007: John C Cambier; Stephen B Gauld; Kevin T Merrell; Barbara J Vilen
B-cell anergy: from transgenic models to naturally occurring anergic B cells?
Nature reviews. Immunology 2007;7(8):633-43.
2007: Maria-Gabriela Velez; Melissa Kane; Sucai Liu; Stephen B Gauld; John C Cambier; Raul M Torres; Roberta Pelanda
Ig allotypic inclusion does not prevent B cell development or response.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1049-57.
2007: Anne M Brauweiler; Kevin T Merrell; Stephen B Gauld; John C Cambier
Cutting Edge: Acute and chronic exposure of immature B cells to antigen leads to impaired homing and SHIP1-dependent reduction in stromal cell-derived factor-1 responsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3353-7.
2007: David M Mills; John C Stolpa; John C Cambier
Modulation of MHC class II signal transduction by CD19.
Advances in experimental medicine and biology 2007;596():139-48.
2006: Kevin T Merrell; Robert J Benschop; Stephen B Gauld; Katja Aviszus; Debora Decote-Ricardo; Lawrence J Wysocki; John C Cambier
Identification of anergic B cells within a wild-type repertoire.
Immunity 2006;25(6):953-62.
2006: Aimee E Pugh-Bernard; John C Cambier
B cell receptor signaling in human systemic lupus erythematosus.
Current opinion in rheumatology 2006;18(5):451-5.
2006: Stephen B Gauld; Kevin T Merrell; John C Cambier
Silencing of autoreactive B cells by anergy: a fresh perspective.
Current opinion in immunology 2006;18(3):292-7.
2005: Stephen B Gauld; Robert J Benschop; Kevin T Merrell; John C Cambier
Maintenance of B cell anergy requires constant antigen receptor occupancy and signaling.
Nature immunology 2005;6(11):1160-7.
2005: John C Cambier
Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling.
Immunological reviews 2005;205():5-6.
2005: Taras Lyubchenko; Joseph M Dal Porto; John C Cambier; V Michael Holers
Coligation of the B cell receptor with complement receptor type 2 (CR2/CD21) using its natural ligand C3dg: activation without engagement of an inhibitory signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3264-72.
2004: Isabelle Isnardi; Renaud Lesourne; Pierre Bruhns; Wolf H Fridman; John C Cambier; Marc Daëron
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
The Journal of biological chemistry 2004;279(50):51931-8.
2004: Stephen B Gauld; John C Cambier
Src-family kinases in B-cell development and signaling.
Oncogene 2004;23(48):8001-6.
2004: Joseph M Dal Porto; Kathy Burke; John C Cambier
Regulation of BCR signal transduction in B-1 cells requires the expression of the Src family kinase Lck.
Immunity 2004;21(3):443-53.
2004: Joseph M Dal Porto; Stephen B Gauld; Kevin T Merrell; David Mills; Aimee E Pugh-Bernard; John C Cambier
B cell antigen receptor signaling 101.
Molecular immunology 2004;41(6-7):599-613.
2004: Michael B Jordan; David M Mills; John Kappler; Philippa Marrack; John C Cambier
Promotion of B cell immune responses via an alum-induced myeloid cell population.
Science (New York, N.Y.) 2004;304(5678):1808-10.
2004: Anne M Brauweiler; John C Cambier
Autonomous SHIP-dependent FcgammaR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death.
Immunology letters 2004;92(1-2):75-81.
2004: Sara A Johnson; John C Cambier
Ageing, autoimmunity and arthritis: senescence of the B cell compartment - implications for humoral immunity.
Arthritis research & therapy 2004;6(4):131-9.
2004: David M Mills; John C Stolpa; John C Cambier
Cognate B cell signaling via MHC class II: differential regulation of B cell antigen receptor and MHC class II/Ig-alpha beta signaling by CD22.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):195-201.
2003: David M Mills; John C Cambier
B lymphocyte activation during cognate interactions with CD4+ T lymphocytes: molecular dynamics and immunologic consequences.
Seminars in immunology 2003;15(6):325-9.
2003: Vanessa L Ott; John C Cambier; John Kappler; Philippa Marrack; Bradley J Swanson
Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.
Nature immunology 2003;4(10):974-81.
2003: Anne M Brauweiler; John C Cambier
Fc gamma RIIB activation leads to inhibition of signalling by independently ligated receptors.
Biochemical Society transactions 2003;31(Pt 1):281-5.
2002: Michael J Chumley; Joseph M Dal Porto; John C Cambier
The unique antigen receptor signaling phenotype of B-1 cells is influenced by locale but induced by antigen.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1735-43.
2002: Susanne Marschner; Thomas Hünig; John C Cambier; Terri H Finkel
Ligation of human CD4 interferes with antigen-induced activation of primary T cells.
Immunology letters 2002;82(1-2):131-9.
2002: Stephen B Gauld; Joseph M Dal Porto; John C Cambier
B cell antigen receptor signaling: roles in cell development and disease.
Science (New York, N.Y.) 2002;296(5573):1641-2.
2002: Sara A Johnson; Stephen Rozzo; John C Cambier
Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5014-23.
2002: Vanessa L Ott; Idan Tamir; Masaru Niki; Pier Paolo Pandolfi; John C Cambier
Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4430-9.
2002: Barbara J Vilen; Kathy M Burke; Michelle Sleater; John C Cambier
Transmodulation of BCR signaling by transduction-incompetent antigen receptors: implications for impaired signaling in anergic B cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4344-51.
2002: Vanessa L Ott; John C Cambier
Introduction: multifaceted roles of lipids and their catabolites in immune cell signaling.
Seminars in immunology 2002;14(1):1-6.
2001: W A Jensen; Susanne Marschner; Vanessa L Ott; John C Cambier
FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization.
Biochemical Society transactions 2001;29(Pt 6):840-6.
2001: Robert J Benschop; E Brandl; A C Chan; John C Cambier
Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4172-9.
2001: Vanessa L Ott; DC Fong; John C Cambier
Fc gamma RIIB as a potential molecular target for intravenous gamma globulin therapy.
The Journal of allergy and clinical immunology 2001;108(4 Suppl):S95-8.
2001: Manfred Kraus; LI Pao; Amy Reichlin; Y Hu; B Canono; John C Cambier; Michel C Nussenzweig; Klaus Rajewsky
Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.
The Journal of experimental medicine 2001;194(4):455-69.
2001: Anne M Brauweiler; Idan Tamir; Susanne Marschner; CD Helgason; John C Cambier
Partially distinct molecular mechanisms mediate inhibitory FcgammaRIIB signaling in resting and activated B cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):204-11.
2001: P Lang; John C Stolpa; Benjamin A Freiberg; F Crawford; John Kappler; Abraham Kupfer; John C Cambier
TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers.
Science (New York, N.Y.) 2001;291(5508):1537-40.
2001: Robert J Benschop; Katja Aviszus; Xianghua Zhang; Tim Manser; John C Cambier; Lawrence J Wysocki
Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive.
Immunity 2001;14(1):33-43.
2000: DC Fong; Anne M Brauweiler; S A Minskoff; Pierre Bruhns; Idan Tamir; I Mellman; M Daeron; John C Cambier
Mutational analysis reveals multiple distinct sites within Fc gamma receptor IIB that function in inhibitory signaling.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4453-62.
2000: Vanessa L Ott; John C Cambier
Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention?
The Journal of allergy and clinical immunology 2000;106(3):429-40.
2000: AM Buhl; David Nemazee; John C Cambier; R Rickert; Marc Hertz
B-cell antigen receptor competence regulates B-lymphocyte selection and survival.
Immunological reviews 2000;176():141-53.
2000: Anne M Brauweiler; Idan Tamir; John C Cambier
Bilevel control of B-cell activation by the inositol 5-phosphatase SHIP.
Immunological reviews 2000;176():69-74.
2000: Idan Tamir; Joseph M Dal Porto; John C Cambier
Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.
Current opinion in immunology 2000;12(3):307-15.
2000: Anne M Brauweiler; Idan Tamir; Joseph M Dal Porto; Robert J Benschop; CD Helgason; R K Humphries; J H Freed; John C Cambier
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP).
The Journal of experimental medicine 2000;191(9):1545-54.
2000: Michael J Chumley; Joseph M Dal Porto; S Kawaguchi; John C Cambier; David Nemazee; Richard R Hardy
A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4586-93.
2000: Idan Tamir; John C Stolpa; CD Helgason; K Nakamura; Pierre Bruhns; M Daeron; John C Cambier
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells.
Immunity 2000;12(3):347-58.
2000: K Nakamura; Anne M Brauweiler; John C Cambier
Effects of Src homology domain 2 (SH2)-containing inositol phosphatase (SHIP), SH2-containing phosphotyrosine phosphatase (SHP)-1, and SHP-2 SH2 decoy proteins on Fc gamma RIIB1-effector interactions and inhibitory functions.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):631-8.
1999: Robert J Benschop; Doron Melamed; David Nemazee; John C Cambier
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.
The Journal of experimental medicine 1999;190(6):749-56.
1999: SJ Famiglietti; K Nakamura; John C Cambier
Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis.
Immunology letters 1999;68(1):35-40.
1999: AM Buhl; John C Cambier
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4438-46.
1999: Robert J Benschop; John C Cambier
B cell development: signal transduction by antigen receptors and their surrogates.
Current opinion in immunology 1999;11(2):143-51.
1999: Barbara J Vilen; T Nakamura; John C Cambier
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization.
Immunity 1999;10(2):239-48.
1999: DC Fong; John C Cambier
Inhibitory receptors and their modes of action.
Cold Spring Harbor symposia on quantitative biology 1999;64():329-34.
1999: John C Cambier; D Fong; Idan Tamir
The unexpected complexity of Fc gamma RIIB signal transduction.
Current topics in microbiology and immunology 1999;244():43-55.
1998: M M Rozdzial; CM Pleiman; John C Cambier; Terri H Finkel
pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5491-9.
1998: Valerie Kouskoff; SJ Famiglietti; Terence Allen; P Lang; JE Rider; Brian Kay; John C Cambier; David Nemazee
Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.
The Journal of experimental medicine 1998;188(8):1453-64.
1998: Chandrasekar Venkataraman; R Lakshman Chelvarajan; John C Cambier; Subbarao Bondada
Interleukin-4 overcomes the negative influence of cyclic AMP accumulation on antigen receptor stimulated B lymphocytes.
Molecular immunology 1998;35(14-15):997-1014.
1998: Chandrasekar Venkataraman; P J Lu; AM Buhl; Ching-Shih Chen; John C Cambier; Subbarao Bondada
CD72-mediated B cell activation involves recruitment of CD19 and activation of phosphatidylinositol 3-kinase.
European journal of immunology 1998;28(10):3003-16.
1998: Idan Tamir; John C Cambier
Antigen receptor signaling: integration of protein tyrosine kinase functions.
Oncogene 1998;17(11 Reviews):1353-64.
1998: K Nakamura; John C Cambier
B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):684-91.
1998: LI Pao; SJ Famiglietti; John C Cambier
Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3305-14.
1998: Odile Malbec; DC Fong; M Turner; Victor L J Tybulewicz; John C Cambier; Wolf H Fridman; Marc Daëron
Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1647-58.
1998: Doron Melamed; Robert J Benschop; John C Cambier; David Nemazee
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.
Cell 1998;92(2):173-82.
1997: AM Buhl; John C Cambier
Co-receptor and accessory regulation of B-cell antigen receptor signal transduction.
Immunological reviews 1997;160():127-38.
1997: AM Buhl; CM Pleiman; R C Rickert; John C Cambier
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization.
The Journal of experimental medicine 1997;186(11):1897-910.
1997: K L Hippen; AM Buhl; D D'Ambrosio; K Nakamura; C Persin; John C Cambier
Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation.
Immunity 1997;7(1):49-58.
1997: Barbara J Vilen; SJ Famiglietti; A M Carbone; Brian Kay; John C Cambier
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):231-43.
1997: John C Cambier
Inhibitory receptors abound?
Proceedings of the National Academy of Sciences of the United States of America 1997;94(12):5993-5.
1997: LI Pao; John C Cambier
Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(6):2663-9.
1997: W A Jensen; CM Pleiman; P Beaufils; A M Wegener; B Malissen; John C Cambier
Qualitatively distinct signaling through T cell antigen receptor subunits.
European journal of immunology 1997;27(3):707-16.
1997: LI Pao; W D Bedzyk; C Persin; John C Cambier
Molecular targets of CD45 in B cell antigen receptor signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(3):1116-24.
1996: D C Fong; Odile Malbec; Michel AROCK; John C Cambier; Wolf H Fridman; Marc Daëron
Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation.
Immunology letters 1996;54(2-3):83-91.
1996: D D'Ambrosio; D C Fong; John C Cambier
The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling.
Immunology letters 1996;54(2-3):77-82.
1996: D D'Ambrosio; K L Hippen; John C Cambier
Distinct mechanisms mediate SHC association with the activated and resting B cell antigen receptor.
European journal of immunology 1996;26(8):1960-5.
1995: John C Cambier
Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM).
Journal of immunology (Baltimore, Md. : 1950) 1995;155(7):3281-5.
1995: G Pani; M Kozlowski; John C Cambier; Gordon B Mills; Katherine A Siminovitch
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.
The Journal of experimental medicine 1995;181(6):2077-84.
1995: D D'Ambrosio; K L Hippen; S A Minskoff; I Mellman; G Pani; Katherine A Siminovitch; John C Cambier
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1.
Science (New York, N.Y.) 1995;268(5208):293-7.
1995: John C Cambier; S A Johnson
Differential binding activity of ARH1/TAM motifs.
Immunology letters 1995;44(2-3):77-80.
1994: F Goldman; W A Jensen; Gary L Johnson; L Heasley; John C Cambier
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):2905-17.
1994: C M Pleiman; C Abrams; L T Gauen; W Bedzyk; J Jongstra; Andrey S Shaw; John C Cambier
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4268-72.
1994: M R Clark; S A Johnson; John C Cambier
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
The EMBO journal 1994;13(8):1911-9.
1994: K Kawauchi; Alan H Lazarus; M J Rapoport; A Harwood; John C Cambier; Terry L Delovitch
Tyrosine kinase and CD45 tyrosine phosphatase activity mediate p21ras activation in B cells stimulated through the antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3306-16.
1994: C M Pleiman; W M Hertz; John C Cambier
Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.
Science (New York, N.Y.) 1994;263(5153):1609-12.
1994: C M Pleiman; N C Chien; John C Cambier
Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2837-44.
1994: P André; John C Cambier; Terri K Wade; T Raetz; William F Wade
Distinct structural compartmentalization of the signal transducing functions of major histocompatibility complex class II (Ia) molecules.
The Journal of experimental medicine 1994;179(2):763-8.
1994: John C Cambier; W A Jensen
The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors.
Current opinion in genetics & development 1994;4(1):55-63.
1993: A E Harwood; John C Cambier
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4513-22.
1993: William F Wade; Jean Davoust; Jean Salamero; P André; Tania H Watts; John C Cambier
Structural compartmentalization of MHC class II signaling function.
Immunology today 1993;14(11):539-46.
1993: C M Pleiman; M R Clark; L K Gauen; S Winitz; K M Coggeshall; Gary L Johnson; Andrey S Shaw; John C Cambier
Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.
Molecular and cellular biology 1993;13(9):5877-87.
1993: John C Cambier; W Bedzyk; K Campbell; N Chien; J Friedrich; A Harwood; W Jensen; C Pleiman; M R Clark
The B-cell antigen receptor: structure and function of primary, secondary, tertiary and quaternary components.
Immunological reviews 1993;132():85-106.
1992: John C Cambier; K S Campbell
Membrane immunoglobulin and its accomplices: new lessons from an old receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1992;6(13):3207-17.
1992: Lawrence J Wysocki; G Creadon; K R Lehmann; John C Cambier
B-cell proliferation initiated by Ia cross-linking and sustained by interleukins leads to class switching but not somatic mutation in vitro.
Immunology 1992;75(1):116-21.
1991: Louis B Justement; K S Campbell; N C Chien; John C Cambier
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45.
Science (New York, N.Y.) 1991;252(5014):1839-42.
1991: Michael Reth; J Hombach; Jürgen Wienands; K S Campbell; N Chien; Louis B Justement; John C Cambier
The B-cell antigen receptor complex.
Immunology today 1991;12(6):196-201.
1991: John C Cambier; D C Morrison; M M Chien; K R Lehmann
Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2075-82.
1991: C L Fisher; J Ghysdael; John C Cambier
Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(6):1743-9.
1990: John C Cambier; C L Fisher; H Pickles; D C Morrison
Dual molecular mechanisms mediate ligand-induced membrane Ig desensitization.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(1):13-9.
1990: M M Chien; John C Cambier
Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C.
The Journal of biological chemistry 1990;265(16):9201-7.
1990: Louis B Justement; Jürgen Wienands; J Hombach; Michael Reth; John C Cambier
Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3272-80.
1990: John C Cambier; K S Campbell
Signal transduction by B lymphocyte receptors: structure-function relationships of membrane immunoglobulins and associated molecules.
Seminars in immunology 1990;2(2):139-49.
1990: K S Campbell; John C Cambier
B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex.
The EMBO journal 1990;9(2):441-8.
1990: D Cross; John C Cambier
Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(2):432-9.
1989: John C Cambier
Transmembrane signaling in T lymphocyte dependent B lymphocyte activation.
Seminars in immunology 1989;1(1):43-54.
1989: John C Cambier; K R Lehmann
Ia-mediated signal transduction leads to proliferation of primed B lymphocytes.
The Journal of experimental medicine 1989;170(3):877-86.
1989: M J Klemsz; Louis B Justement; E Palmer; John C Cambier
Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):1032-9.
1989: Louis B Justement; J Kreiger; John C Cambier
Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(3):881-9.
1989: William F Wade; Z Z Chen; R Maki; Scott R McKercher; E Palmer; John C Cambier; J H Freed
Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(16):6297-301.
1988: J T Ransom; M Chen; V M Sandoval; J A Pasternak; D Digiusto; John C Cambier
Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(9):3150-5.
1987: John C Cambier; M Karen Newell; Louis B Justement; J C McGuire; K L Leach; Z Z Chen
Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes.
Nature 1987;327(6123):629-32.
1987: Z Z Chen; J C McGuire; K L Leach; John C Cambier
Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(7):2345-52.
1987: John C Cambier; Louis B Justement; M Karen Newell; Z Z Chen; L K Harris; V M Sandoval; M J Klemsz; J T Ransom
Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation.
Immunological reviews 1987;95():37-57.
1987: John C Cambier; Z Z Chen; J T Ransom; K Mark Coggeshall; M J Klemsz; L K Harris; V M Sandoval; M Karen Newell
Differential transmembrane signaling in B lymphocyte activation.
Annals of the New York Academy of Sciences 1987;494():52-64.
1987: John C Cambier; J T Ransom; L K Harris; K Mark Coggeshall; Z Z Chen; M Karen Newell; Louis B Justement
Coupling of B cell surface Ig, Ia and BSF1 receptors to intracellular "second messengers".
Advances in experimental medicine and biology 1987;213():195-205.
1986: J T Ransom; L K Harris; John C Cambier
Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(2):708-14.
1986: Z Z Chen; K Mark Coggeshall; John C Cambier
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(6):2300-4.
1986: J T Ransom; D L DiGiusto; John C Cambier
Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(1):54-7.