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Daniel Offen

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Chen Benkler; Tali Ben-Zur; Yael Barhum; Daniel Offen
Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis.
Nirit Lev; Eldad Melamed; Yael Barhum; Haim Y Cohen; Debby Ickowicz; Neri S Pilosof; Daniel Offen
DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.
Noam Shemesh; Nir Sochen; Yuval Zur; Daniel Offen; Ofer Sadan; Yaniv Assaf; Leah Bar; Daniel Barazany; Yael Barhum; Yoram Cohen
Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI.

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All Publications

2013: Chen Benkler; Tali Ben-Zur; Yael Barhum; Daniel Offen
Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis.
Glia 2013;61(3):312-26.
2013: Nirit Lev; Eldad Melamed; Yael Barhum; Haim Y Cohen; Debby Ickowicz; Neri S Pilosof; Daniel Offen
DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2013;68(3):215-25.
2012: Noam Shemesh; Nir Sochen; Yuval Zur; Daniel Offen; Ofer Sadan; Yaniv Assaf; Leah Bar; Daniel Barazany; Yael Barhum; Yoram Cohen
Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2012;68(3):794-806.
2012: O Sadan; N Shemesh; M Yeshurun; Yaniv Assaf; R Barzilay; T Blumenfeld-Katzir; Y Cohen; M Dadon-Nahum; R Djaldetti; Eldad Melamed; Daniel Offen
Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease.
Experimental neurology 2012;234(2):417-27.
2012: Adi Shruster; Tali Ben-Zur; Eldad Melamed; Daniel Offen
Wnt signaling enhances neurogenesis and improves neurological function after focal ischemic injury.
PloS one 2012;7(7):e40843.
2011: Javier Ganz; Nirit Lev; Eldad Melamed; Daniel Offen
Cell replacement therapy for Parkinson's disease: how close are we to the clinic?
Expert review of neurotherapeutics 2011;11(9):1325-39.
2011: Michal Dadon-Nachum; Eldad Melamed; Ofer Sadan; Itay Srugo; Daniel Offen
Differentiated mesenchymal stem cells for sciatic nerve injury.
Stem cell reviews 2011;7(3):664-71.
2011: Inna Kan; Yael Barhum; Eldad Melamed; Daniel Offen
Mesenchymal stem cells stimulate endogenous neurogenesis in the subventricular zone of adult mice.
Stem cell reviews 2011;7(2):404-12.
2011: Michal Dadon-Nachum; Eldad Melamed; Daniel Offen
The "dying-back" phenomenon of motor neurons in ALS.
Journal of molecular neuroscience : MN 2011;43(3):470-7.
2010: Hana Levkovitch-Verbin; Ofer Sadan; Shelly Vander; Mordechai Rosner; Yael Barhum; Eldad Melamed; Daniel Offen; Shlomo Melamed
Intravitreal injections of neurotrophic factors secreting mesenchymal stem cells are neuroprotective in rat eyes following optic nerve transection.
Investigative ophthalmology & visual science 2010;51(12):6394-400.
2010: Chen Benkler; Lana Kupershmidt; Silvia Mandel; Eldad Melamed; Daniel Offen; Tamar Amit; Moussa B H Youdim; Orly Weinreb
Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application.
The EPMA journal 2010;1(2):343-61.
2010: Yael Barhum; Sharon Gai-Castro; Merav Bahat-Stromza; Ran Barzilay; Eldad Melamed; Daniel Offen
Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis.
Journal of molecular neuroscience : MN 2010;41(1):129-37.
2010: Noam Shemesh; Ofer Sadan; Eldad Melamed; Daniel Offen; Yoram Cohen
Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N-acetyl aspartate levels.
NMR in biomedicine 2010;23(2):196-206.
2009: Ofer Sadan; Eldad Melamed; Daniel Offen
Bone-marrow-derived mesenchymal stem cell therapy for neurodegenerative diseases.
Expert opinion on biological therapy 2009;9(12):1487-97.
2009: Ran Barzilay; Eldad Melamed; Daniel Offen
Introducing transcription factors to multipotent mesenchymal stem cells: making transdifferentiation possible.
Stem cells (Dayton, Ohio) 2009;27(10):2509-15.
2009: Ofer Sadan; Merav Bahat-Stromza; Yael Barhum; Yossef S Levy; Anat Pisnevsky; Hagit Peretz; Avihay Bar Ilan; Shlomo Bulvik; Noam Shemesh; Dana Krepel; Yoram Cohen; Eldad Melamed; Daniel Offen
Protective effects of neurotrophic factor-secreting cells in a 6-OHDA rat model of Parkinson disease.
Stem cells and development 2009;18(8):1179-90.
2009: Merav Bahat-Stroomza; Yael Barhum; Yossef S Levy; Olga Karpov; Shlomo Bulvik; Eldad Melamed; Daniel Offen
Induction of adult human bone marrow mesenchymal stromal cells into functional astrocyte-like cells: potential for restorative treatment in Parkinson's disease.
Journal of molecular neuroscience : MN 2009;39(1-2):199-210.
2009: Nirit Lev; Debby Ickowicz; Yael Barhum; Eldad Melamed; Daniel Offen
DJ-1 changes in G93A-SOD1 transgenic mice: implications for oxidative stress in ALS.
Journal of molecular neuroscience : MN 2009;38(2):94-102.
2009: Daniel Offen; Yael Barhum; Eldad Melamed; Norbert Embacher; Christoph Schindler; Gerhard Ransmayr
Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant.
Journal of molecular neuroscience : MN 2009;38(2):85-93.
2009: Ran Barzilay; Tali Ben-Zur; Shlomo Bulvik; Eldad Melamed; Daniel Offen
Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells.
Stem cells and development 2009;18(4):591-601.
2009: Ofer Sadan; Noam Shemesh; Yoram Cohen; Eldad Melamed; Daniel Offen
Adult neurotrophic factor-secreting stem cells: a potential novel therapy for neurodegenerative diseases.
The Israel Medical Association journal : IMAJ 2009;11(4):201-4.
2009: Nirit Lev; Debby Ickowicz; Yael Barhum; Shaul Lev; Eldad Melamed; Daniel Offen
DJ-1 protects against dopamine toxicity.
Journal of neural transmission (Vienna, Austria : 1996) 2009;116(2):151-60.
2009: Ran Barzilay; Ofer Sadan; Eldad Melamed; Daniel Offen
Comparative characterization of bone marrow-derived mesenchymal stromal cells from four different rat strains.
Cytotherapy 2009;11(4):435-42.
2009: Nurit Grunberg-Etkovitz; Nirit Lev; Debby Ickowicz; Almog Avital; Daniel Offen; zvi malik
Accelerated proteasomal activity induced by Pb2+, Ga3+, or Cu2+ exposure does not induce degradation of alpha-synuclein.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2009;28(1):5-24.
2008: Ofer Sadan; Noam Shemesh; Ran Barzilay; Merav Bahat-Stromza; Eldad Melamed; Yoram Cohen; Daniel Offen
Migration of neurotrophic factors-secreting mesenchymal stem cells toward a quinolinic acid lesion as viewed by magnetic resonance imaging.
Stem cells (Dayton, Ohio) 2008;26(10):2542-51.
2008: Ran Barzilay; Inna Kan; Tali Ben-Zur; Shlomo Bulvik; Eldad Melamed; Daniel Offen
Induction of human mesenchymal stem cells into dopamine-producing cells with different differentiation protocols.
Stem cells and development 2008;17(3):547-54.
2008: Nirit Lev; Debby Ickowicz; Eldad Melamed; Daniel Offen
Oxidative insults induce DJ-1 upregulation and redistribution: implications for neuroprotection.
Neurotoxicology 2008;29(3):397-405.
2008: O Dratviman-Storobinsky; murat hasanreisoglu; Daniel Offen; Y Barhum; D Weinberger; Nitza Goldenberg-Cohen
Progressive damage along the optic nerve following induction of crush injury or rodent anterior ischemic optic neuropathy in transgenic mice.
Molecular vision 2008;14():2171-9.
2008: Yossef S Levy; M Bahat-Stroomza; R Barzilay; A Burshtein; Shlomo Bulvik; Yael Barhum; Hana Panet; Eldad Melamed; Daniel Offen
Regenerative effect of neural-induced human mesenchymal stromal cells in rat models of Parkinson's disease.
Cytotherapy 2008;10(4):340-52.
2007: Ziv Ben-Ari; Orit Pappo; Yelena Cheporko; Natali Yasovich; Daniel Offen; Asher Shainberg; Dorit Leshem; Jaqueline Sulkes; Bernardo A Vidne; Edith Hochhauser
Bax ablation protects against hepatic ischemia/reperfusion injury in transgenic mice.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2007;13(8):1181-8.
2007: Inna Kan; Tali Ben-Zur; Yael Barhum; Yossef S Levy; Alex Burstein; Tirza Charlow; Shlomo Bulvik; Eldad Melamed; Daniel Offen
Dopaminergic differentiation of human mesenchymal stem cells--utilization of bioassay for tyrosine hydroxylase expression.
Neuroscience letters 2007;419(1):28-33.
2007: Inna Kan; Eldad Melamed; Daniel Offen; Pnina Green
Docosahexaenoic acid and arachidonic acid are fundamental supplements for the induction of neuronal differentiation.
Journal of lipid research 2007;48(3):513-7.
2007: Jonathan F Grunfeld; Yael Barhum; Netta Blondheim; Jose Martin Rabey; Eldad Melamed; Daniel Offen
Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model.
Experimental neurology 2007;204(1):260-3.
2007: Nirit Lev; Eldad Melamed; Daniel Offen
Toxic causes of parkinsonism.
Handbook of clinical neurology 2007;84():385-98.
2007: Daniel Offen; Yael Barhum; Yossef S Levy; A Burshtein; Hana Panet; T Cherlow; Eldad Melamed
Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease.
Journal of neural transmission. Supplementum 2007;(72):133-43.
2007: Inna Kan; Eldad Melamed; Daniel Offen
Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases.
Handbook of experimental pharmacology 2007;(180):219-42.
2007: Edith Hochhauser; Yelena Cheporko; N Yasovich; L Pinchas; Daniel Offen; Yael Barhum; H Pannet; A Tobar; B A Vidne; Einat Birk
Bax deficiency reduces infarct size and improves long-term function after myocardial infarction.
Cell biochemistry and biophysics 2007;47(1):11-20.
2006: Nirit Lev; Debby Ickowicz; Yael Barhum; Netta Blondheim; Eldad Melamed; Daniel Offen
Experimental encephalomyelitis induces changes in DJ-1: implications for oxidative stress in multiple sclerosis.
Antioxidants & redox signaling 2006;8(11-12):1987-95.
2006: Nirit Lev; Eldad Melamed; Daniel Offen
Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.
Neuroscience letters 2006;399(1-2):27-32.
2006: Netta Blondheim; Yossef S Levy; Tali Ben-Zur; Alex Burshtein; Tirza Cherlow; Inna Kan; Ran Barzilai; Merav Bahat-Stromza; Yael Barhum; Shlomo Bulvik; Eldad Melamed; Daniel Offen
Human mesenchymal stem cells express neural genes, suggesting a neural predisposition.
Stem cells and development 2006;15(2):141-64.
2006: Mark A Hellmann; Hana Panet; Yael Barhum; Eldad Melamed; Daniel Offen
Increased survival and migration of engrafted mesenchymal bone marrow stem cells in 6-hydroxydopamine-lesioned rodents.
Neuroscience letters 2006;395(2):124-8.
2006: Nirit Lev; Dusan Roncevic; Dusan Roncevich; Debby Ickowicz; Eldad Melamed; Daniel Offen
Role of DJ-1 in Parkinson's disease.
Journal of molecular neuroscience : MN 2006;29(3):215-25.
2006: Yossi Gilgun-Sherki; Eldad Melamed; Daniel Offen
Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state.
Current pharmaceutical design 2006;12(27):3509-19.
2006: Ran Barzilay; Yossef S Levy; Eldad Melamed; Daniel Offen
Adult stem cells for neuronal repair.
The Israel Medical Association journal : IMAJ 2006;8(1):61-6.
2005: Ofer Sadan; Merav Bahat-Stromza; Yossi Gilgun-Sherki; Daphne Atlas; Eldad Melamed; Daniel Offen
A novel brain-targeted antioxidant (AD4) attenuates haloperidol-induced abnormal movement in rats: implications for tardive dyskinesia.
Clinical neuropharmacology 2005;28(6):285-8.
2005: Merav Bahat-Stroomza; Yossi Gilgun-Sherki; Daniel Offen; Hana Panet; Ann Saada (Reisch); Nili Krool-Galron; Aari Barzilai; Daphne Atlas; Eldad Melamed
A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease.
The European journal of neuroscience 2005;21(3):637-46.
2005: Inna Kan; Eldad Melamed; Daniel Offen
Integral therapeutic potential of bone marrow mesenchymal stem cells.
Current drug targets 2005;6(1):31-41.
2005: Yossi Gilgun-Sherki; Yael Barhum; Daphne Atlas; Eldad Melamed; Daniel Offen
Analysis of gene expression in MOG-induced experimental autoimmune encephalomyelitis after treatment with a novel brain-penetrating antioxidant.
Journal of molecular neuroscience : MN 2005;27(1):125-35.
2005: Yossef S Levy; Yossi Gilgun-Sherki; Eldad Melamed; Daniel Offen
Therapeutic potential of neurotrophic factors in neurodegenerative diseases.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2005;19(2):97-127.
2004: Daniel Offen; Yossi Gilgun-Sherki; Yael Barhum; Moran Benhar; Leonid Grinberg; Reuven Reich; Eldad Melamed; Daphne Atlas
A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis.
Journal of neurochemistry 2004;89(5):1241-51.
2004: Nirit Lev; Yael Barhum; Eldad Melamed; Daniel Offen
Bax-ablation attenuates experimental autoimmune encephalomyelitis in mice.
Neuroscience letters 2004;359(3):139-42.
2004: Yossi Gilgun-Sherki; Eldad Melamed; Daniel Offen
The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy.
Journal of neurology 2004;251(3):261-8.
2004: Hanock Elkon; Eldad Melamed; Daniel Offen
Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells: implications for the pathogenesis of Parkinson's disease.
Journal of molecular neuroscience : MN 2004;24(3):387-400.
2004: Yossef S Levy; Merav Stroomza; Eldad Melamed; Daniel Offen
Embryonic and adult stem cells as a source for cell therapy in Parkinson's disease.
Journal of molecular neuroscience : MN 2004;24(3):353-86.
2004: Yossi Gilgun-Sherki; Ruth Djaldetti; Eldad Melamed; Daniel Offen
Polymorphism in candidate genes: implications for the risk and treatment of idiopathic Parkinson's disease.
The pharmacogenomics journal 2004;4(5):291-306.
2003: Yossi Gilgun-Sherki; Hana Panet; Eldad Melamed; Daniel Offen
Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis.
Brain research 2003;989(2):196-204.
2003: Yossi Gilgun-Sherki; Hana Panet; Vered Holdengreber; Ronit Mosberg-Galili; Daniel Offen
Axonal damage is reduced following glatiramer acetate treatment in C57/bl mice with chronic-induced experimental autoimmune encephalomyelitis.
Neuroscience research 2003;47(2):201-7.
2003: Yossi Gilgun-Sherki; Eldad Melamed; Urij Rampampam; Daniel Offen
The CB1 cannabinoid receptor agonist, HU-210, reduces levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.
Pharmacology & toxicology 2003;93(2):66-70.
2003: Yossi Gilgun-Sherki; Eldad Melamed; Ilan Ziv; Daniel Offen
Riluzole, an inhibitor of glutamatergic transmission, suppresses levodopa-induced rotations in 6-hydroxydopamine-lesioned rats.
Pharmacology & toxicology 2003;93(1):54-6.
2003: Edith Hochhauser; Shmuel Kivity; Daniel Offen; Nilanjana Maulik; Hajime Otani; Yael Barhum; Hannah Pannet; Vladimir Shneyvays; Asher Shainberg; Valeri Goldshtaub; Anna Tobar; Bernardo A Vidne
Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice.
American journal of physiology. Heart and circulatory physiology 2003;284(6):H2351-9.
2003: Nirit Lev; Eldad Melamed; Daniel Offen
Apoptosis and Parkinson's disease.
Progress in neuro-psychopharmacology & biological psychiatry 2003;27(2):245-50.
2003: Yossef S Levy; Doron Merims; Hana Panet; Yael Barhum; Eldad Melamed; Daniel Offen
Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.
Journal of molecular neuroscience : MN 2003;21(2):121-32.
2003: Yossi Gilgun-Sherki; Eldad Melamed; Daniel Offen
Antioxidant treatment in Alzheimer's disease: current state.
Journal of molecular neuroscience : MN 2003;21(1):1-11.
2003: Ari Barzilai; Dorah Daily; Rina Zilkha-Falb; Ilan Ziv; Daniel Offen; Eldad Melamed; Anat Shirvan
The molecular mechanisms of dopamine toxicity.
Advances in neurology 2003;91():73-82.
2002: Hanock Elkon; Jermy Don; Eldad Melamed; Ilan Ziv; Anat Shirvan; Daniel Offen
Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase.
Journal of molecular neuroscience : MN 2002;18(3):229-38.
2002: Yossi Gilgun-Sherki; Ziv Rosenbaum; Eldad Melamed; Daniel Offen
Antioxidant therapy in acute central nervous system injury: current state.
Pharmacological reviews 2002;54(2):271-84.
2001: Daniel Offen; Biana Shtaif; D Hadad; Abraham Weizman; Eldad Melamed; Irit Gil-Ad
Protective effect of insulin-like-growth-factor-1 against dopamine-induced neurotoxicity in human and rodent neuronal cultures: possible implications for Parkinson's disease.
Neuroscience letters 2001;316(3):129-32.
2001: Hanock Elkon; Eldad Melamed; Daniel Offen
6-Hydroxydopamine increases ubiquitin-conjugates and protein degradation: implications for the pathogenesis of Parkinson's disease.
Cellular and molecular neurobiology 2001;21(6):771-81.
2001: Dorah Daily; A Vlamis-Gardikas; Daniel Offen; Leonid Mittelman; Eldad Melamed; A Holmgren; Ari Barzilai
Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways.
The Journal of biological chemistry 2001;276(24):21618-26.
2001: Yossi Gilgun-Sherki; Eldad Melamed; Daniel Offen
Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier.
Neuropharmacology 2001;40(8):959-75.
2001: Hana Panet; Ari Barzilai; Dorah Daily; Eldad Melamed; Daniel Offen
Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells.
Journal of neurochemistry 2001;77(2):391-8.
2001: Miquel Vila; Vernice Jackson-Lewis; S Vukosavic; Ruth Djaldetti; GT Liberatore; Daniel Offen; S J Korsmeyer; Serge Przedborski
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2837-42.
2001: Dorah Daily; A Vlamis-Gardikas; Daniel Offen; Leonid Mittelman; Eldad Melamed; A Holmgren; Ari Barzilai
Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by activating NF-kappa B via Ref-1.
The Journal of biological chemistry 2001;276(2):1335-44.
2001: Ilan Ziv; Anat Shirvan; Daniel Offen; Ari Barzilai; Eldad Melamed
Molecular biology of dopamine-induced apoptosis : possible implications for Parkinson's disease.
Methods in molecular medicine 2001;62():73-87.
2001: Daniel Offen; Hana Panet; R Galili-Mosberg; Eldad Melamed
Catechol-O-methyltransferase decreases levodopa toxicity in vitro.
Clinical neuropharmacology 2001;24(1):27-30.
2000: Daniel Offen; Joel F Kaye; O Bernard; Doron Merims; C I Coire; Hana Panet; Eldad Melamed; Avraham Ben-Nun
Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE).
Journal of molecular neuroscience : MN 2000;15(3):167-76.
2000: Eldad Melamed; Daniel Offen; Anat Shirvan; Ilan Ziv
Levodopa--an exotoxin or a therapeutic drug?
Journal of neurology 2000;247 Suppl 2():II135-9.
2000: Ayala Hochman; Huiyun Liang; Daniel Offen; Eldad Melamed; H Sternin
Developmental changes in antioxidant enzymes and oxidative damage in kidneys, liver and brain of bcl-2 knockout mice.
Cellular and molecular biology (Noisy-le-Grand, France) 2000;46(1):41-52.
2000: Daniel Offen; Y Sherki; Eldad Melamed; Mati Fridkin; Douglas E Brenneman; Illana Gozes
Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: relevance to neuroprotection in Parkinson's disease.
Brain research 2000;854(1-2):257-62.
2000: R Galili; Irit Gil-Ad; A Weizman; Eldad Melamed; Daniel Offen
Haloperidol-induced neurotoxicity--possible implications for tardive dyskinesia.
Journal of neural transmission (Vienna, Austria : 1996) 2000;107(4):479-90.
2000: Ari Barzilai; Rina Zilkha-Falb; Dorah Daily; Naftali Stern; Daniel Offen; Ilan Ziv; Eldad Melamed; Anat Shirvan
The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity.
Journal of neural transmission. Supplementum 2000;(60):59-76.
2000: Daniel Offen; Hanock Elkon; Eldad Melamed
Apoptosis as a general cell death pathway in neurodegenerative diseases.
Journal of neural transmission. Supplementum 2000;(58):153-66.
1999: Dorah Daily; Ari Barzilai; Daniel Offen; A Kamsler; Eldad Melamed; Ilan Ziv
The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.
Cellular and molecular neurobiology 1999;19(2):261-76.
1999: Daniel Offen; Svetlana Gorodin; Eldad Melamed; J Hanania; Z Malik
Dopamine-melanin is actively phagocytized by PC12 cells and cerebellar granular cells: possible implications for the etiology of Parkinson's disease.
Neuroscience letters 1999;260(2):101-4.
1999: Daniel Offen; Ayala Hochman; Svetlana Gorodin; Ilan Ziv; Anat Shirvan; Ari Barzilai; Eldad Melamed
Oxidative stress and neuroprotection in Parkinson's disease: implications from studies on dopamine-induced apoptosis.
Advances in neurology 1999;80():265-9.
1998: Daniel Offen; S Halevi; D Orion; R Mosberg; H Stern-Goldberg; Eldad Melamed; Daphne Atlas
Antibodies from ALS patients inhibit dopamine release mediated by L-type calcium channels.
Neurology 1998;51(4):1100-3.
1998: Eldad Melamed; Daniel Offen; Anat Shirvan; Ruth Djaldetti; Ari Barzilai; Ilan Ziv
Levodopa toxicity and apoptosis.
Annals of neurology 1998;44(3 Suppl 1):S149-54.
1998: Ayala Hochman; H Sternin; Svetlana Gorodin; S Korsmeyer; Ilan Ziv; Eldad Melamed; Daniel Offen
Enhanced oxidative stress and altered antioxidants in brains of Bcl-2-deficient mice.
Journal of neurochemistry 1998;71(2):741-8.
1998: Daniel Offen; Philip M Beart; Nam Sang Cheung; CJ Pascoe; Ayala Hochman; Svetlana Gorodin; Eldad Melamed; R Bernard; O Bernard
Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(10):5789-94.
1998: Daniel Offen; Anat Achiron; L Wasserman; M Miller; Mati Shaklai; Ron Dabby; Svetlana Gorodin; Batya Shohat
HTLV-1 in mouthwash cells from a TSP/HAM patient and asymptomatic carriers.
Archives of virology 1998;143(5):1029-34.
1997: Daniel Offen; Ilan Ziv; Ari Barzilai; Svetlana Gorodin; E Glater; Ayala Hochman; Eldad Melamed
Dopamine-melanin induces apoptosis in PC12 cells; possible implications for the etiology of Parkinson's disease.
Neurochemistry international 1997;31(2):207-16.
1997: Daniel Offen; Ilan Ziv; Hana Panet; L Wasserman; R Stein; Eldad Melamed; Ari Barzilai
Dopamine-induced apoptosis is inhibited in PC12 cells expressing Bcl-2.
Cellular and molecular neurobiology 1997;17(3):289-304.
1997: Rina Zilkha-Falb; Ilan Ziv; N Nardi; Daniel Offen; Eldad Melamed; Ari Barzilai
Monoamine-induced apoptotic neuronal cell death.
Cellular and molecular neurobiology 1997;17(1):101-18.
1997: Ilan Ziv; Daniel Offen; R Haviv; R Stein; Hana Panet; Rina Zilkha-Falb; Anat Shirvan; Ari Barzilai; Eldad Melamed
The proto-oncogene Bcl-2 inhibits cellular toxicity of dopamine: possible implications for Parkinson's disease.
Apoptosis : an international journal on programmed cell death 1997;2(2):149-55.
1997: Ilan Ziv; Daniel Offen; Ari Barzilai; R Haviv; R Stein; Rina Zilkha-Falb; Anat Shirvan; Eldad Melamed
Modulation of control mechanisms of dopamine-induced apoptosis--a future approach to the treatment of Parkinson's disease?
Journal of neural transmission. Supplementum 1997;49():195-202.
1997: Ilan Ziv; Ari Barzilai; Daniel Offen; N Nardi; Eldad Melamed
Nigrostriatal neuronal death in Parkinson's disease--a passive or an active genetically-controlled process?
Journal of neural transmission. Supplementum 1997;49():69-76.
1997: Ilan Ziv; Rina Zilkha-Falb; Daniel Offen; Anat Shirvan; Ari Barzilai; Eldad Melamed
Levodopa induces apoptosis in cultured neuronal cells--a possible accelerator of nigrostriatal degeneration in Parkinson's disease?
Movement disorders : official journal of the Movement Disorder Society 1997;12(1):17-23.
1996: Daniel Offen; Ilan Ziv; H Sternin; Eldad Melamed; Ayala Hochman
Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease.
Experimental neurology 1996;141(1):32-9.
1996: Anat Achiron; Orit Pinhas-Hamiel; Yoram Barak; L Doll; Daniel Offen; Ruth Djaldetti; G Frankel; B Shohat
Detection of proviral human T-cell lymphotrophic virus type I DNA in mouthwash samples of HAM/TSP patients and HTLV-I carriers.
Archives of virology 1996;141(1):147-53.
1996: Ilan Ziv; Ari Barzilai; Daniel Offen; R Stein; Anat Achiron; Eldad Melamed
Dopamine-induced, genotoxic activation of programmed cell death. A role in nigrostriatal neuronal degeneration in Parkinson's disease?
Advances in neurology 1996;69():229-33.
1995: Daniel Offen; Ilan Ziv; Svetlana Gorodin; Ari Barzilai; Z Malik; Eldad Melamed
Dopamine-induced programmed cell death in mouse thymocytes.
Biochimica et biophysica acta 1995;1268(2):171-7.
1994: Ilan Ziv; Eldad Melamed; N Nardi; D Luria; Anat Achiron; Daniel Offen; Ari Barzilai
Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons--a possible novel pathogenetic mechanism in Parkinson's disease.
Neuroscience letters 1994;170(1):136-40.
1992: Daniel Offen; L Spatz; H Escowitz; Stephen M Factor; Betty Diamond
Induction of tolerance to an IgG autoantibody.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(17):8332-6.
1991: Joseph Sperling; Judith Chebath; H Arad-Dann; Daniel Offen; P Spann; R Lehrer; D Goldblatt; B Jolles; Ruth Sperling
Possible involvement of (2'5')oligoadenylate synthetase activity in pre-mRNA splicing.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10377-81.
1991: G Ast; D Goldblatt; Daniel Offen; Joseph Sperling; Ruth Sperling
A novel splicing factor is an integral component of 200S large nuclear ribonucleoprotein (InRNP) particles.
The EMBO journal 1991;10(2):425-32.
1990: Daniel Offen; S Mendlovic; H Fricke; Ruth Sperling; Joseph Sperling; Edna Mozes
Monoclonal anti-La antibody derived from a mouse with experimental SLE is similar to human anti-La antibodies.
Journal of autoimmunity 1990;3(6):701-13.
1990: E Paul; A Manheimer-Lory; A Livneh; A Solomon; Cynthia Aranow; C Ghossein; R Shefner; Daniel Offen; M Pillinger; Betty Diamond
Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins.
International reviews of immunology 1990;5(3-4):295-313.
1990: G Ast; Daniel Offen; D Goldblatt; Ruth Sperling; Joseph Sperling
Identification of nuclear RNP proteins as pre-mRNA splicing factors.
Molecular biology reports 1990;14(2-3):193.
1990: H Fricke; Daniel Offen; S Mendlovic; Yehuda Shoenfeld; R Bakimer; Joseph Sperling; Edna Mozes
Induction of experimental systemic lupus erythematosus in mice by immunization with a monoclonal anti-La autoantibody.
International immunology 1990;2(3):225-30.
1987: H Arad-Dann; D A Isenberg; Yehuda Shoenfeld; Daniel Offen; Joseph Sperling; Ruth Sperling
Autoantibodies against a specific nuclear RNP protein in sera of patients with autoimmune rheumatic diseases associated with myositis.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(8):2463-8.
1986: Ruth Sperling; P Spann; Daniel Offen; Joseph Sperling
U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(18):6721-5.
1975: D M Symes; Daniel Offen; J A Lyttle; J P Blandy
The effect of dicynene on blood loss during and after transurethral resection of the prostate.
British journal of urology 1975;47(2):203-7.
1974: M J Raphael; K Moazzez; Daniel Offen
Vascular manifestations of thoracic outlet compression: angiographic appearances.
Angiology 1974;25(4):237-48.
1973: A P Barabas; Daniel Offen; E A Meinhard
The arterial complications of polycythaemia vera.
The British journal of surgery 1973;60(3):183-7.