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Xue-Liang Du

Research Profile

Chemicals & Drugs

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Physiology

Enzyme Activation

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Publications

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Andreas Schlotterer; Andreas Hamann; Georgi Kukudov; Youssef Ibrahim; Britta Heckmann; Farastuk Bozorgmehr; Michael Pfeiffer; Harald Hutter; David Stern; Xue-Liang Du; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
Maria D'Apolito; Xue-Liang Du; Haihong Zong; Alessandra Catucci; Luigi Maiuri; Tiziana Trivisano; Massimo Pettoello-Mantovani; Angelo Campanozzi; Valeria Raia; Jeffrey Pessin; Michael Brownlee; Ida Giardino
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.
Andreas Schlotterer; Georgi Kukudov; Farastuk Bozorgmehr; Harald Hutter; Xue-Liang Du; Dimitrios Oikonomou; Youssef Ibrahim; Friederike Pfisterer; Naila Rabbani; Paul Thornalley; Ahmed A R Sayed; Thomas Fleming; Per M Humpert; Vedat Schwenger; Martin Zeier; Andreas Hamann; David Stern; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
C. elegans as model for the study of high glucose- mediated life span reduction.

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All Publications

2010: Andreas Schlotterer; Andreas Hamann; Georgi Kukudov; Youssef Ibrahim; Britta Heckmann; Farastuk Bozorgmehr; Michael Pfeiffer; Harald Hutter; David Stern; Xue-Liang Du; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
Apurinic/apyrimidinic endonuclease 1, p53, and thioredoxin are linked in control of aging in C. elegans.
Aging cell 2010;9(3):420-32.
2010: Maria D'Apolito; Xue-Liang Du; Haihong Zong; Alessandra Catucci; Luigi Maiuri; Tiziana Trivisano; Massimo Pettoello-Mantovani; Angelo Campanozzi; Valeria Raia; Jeffrey Pessin; Michael Brownlee; Ida Giardino
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.
The Journal of clinical investigation 2010;120(1):203-13.
2009: Andreas Schlotterer; Georgi Kukudov; Farastuk Bozorgmehr; Harald Hutter; Xue-Liang Du; Dimitrios Oikonomou; Youssef Ibrahim; Friederike Pfisterer; Naila Rabbani; Paul Thornalley; Ahmed A R Sayed; Thomas Fleming; Per M Humpert; Vedat Schwenger; Martin Zeier; Andreas Hamann; David Stern; Michael Brownlee; Angelika Bierhaus; Peter Nawroth; Michael Morcos
C. elegans as model for the study of high glucose- mediated life span reduction.
Diabetes 2009;58(11):2450-6.
2009: Hariharan Thangarajah; Dachun Yao; Edward I Chang; Yubin Shi; Leila Jazayeri; Ivan N Vial; Robert D Galiano; Xue-Liang Du; Raymon Grogan; Michael G Galvez; Michael Januszyk; Michael Brownlee; Geoffrey C Gurtner
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(32):13505-10.
2008: Xue-Liang Du; Diane Edelstein; Michael Brownlee
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Diabetologia 2008;51(10):1930-2.
2008: Michael Morcos; Xue-Liang Du; Friederike Pfisterer; Harald Hutter; Ahmed A R Sayed; Paul Thornalley; Naila Ahmed; John W Baynes; Suzanne R Thorpe; Georgi Kukudov; Andreas Schlotterer; Farastuk Bozorgmehr; Randa Abd El Baki; David M Stern; Frank Moehrlen; Youssef Ibrahim; Dimitrios Oikonomou; Andreas Hamann; Christian Becker; Martin Zeier; Vedat Schwenger; Nexhat Miftari; Per Humpert; Hans-Peter Hammes; Markus Buechler; Angelika Bierhaus; Michael Brownlee; Peter P Nawroth
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
Aging cell 2008;7(2):260-9.
2006: Xue-Liang Du; Diane Edelstein; Silvana Obici; Ninon Higham; Ming-Hui Zou; Michael Brownlee
Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation.
The Journal of clinical investigation 2006;116(4):1071-80.
2006: N R F Nascimento; Lucília Maria Abreu Lessa; Marta Regina Kerntopf; C M Sousa; Renata Sousa Alves; M G R Queiroz; J Price; Douglas B Heimark; James M Larner; Xue-Liang Du; Michael Brownlee; Alexander Gow; C Davis; Manassés C Fonteles
Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(1):218-23.
2005: Ying Lin; Anders H Berg; Puneeth Iyengar; Tony K T Lam; Adria Giacca; Terry P Combs; Michael W Rajala; Xue-Liang Du; Brent Rollman; Weijie Li; Meredith Hawkins; Nir Barzilai; Christopher J Rhodes; I George Fantus; Michael Brownlee; Philipp E Scherer
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
The Journal of biological chemistry 2005;280(6):4617-26.
2003: Xue-Liang Du; Takeshi Matsumura; Diane Edelstein; Luciano Rossetti; Zsuzsanna Zsengellér; Csaba Szabó; Michael Brownlee
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
The Journal of clinical investigation 2003;112(7):1049-57.
2003: Utpal B Pajvani; Xue-Liang Du; Terry P Combs; Anders H Berg; Michael W Rajala; Therese Schulthess; Jürgen Engel; Michael Brownlee; Philipp E Scherer
Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity.
The Journal of biological chemistry 2003;278(11):9073-85.
2003: Hans-Peter Hammes; Xue-Liang Du; Diane Edelstein; Tetsuya Taguchi; Takeshi Matsumura; Qida Ju; Jihong Lin; Angelika Bierhaus; Peter Nawroth; Dieter Hannak; Michael Neumaier; Regine Bergfeld; Ida Giardino; Michael Brownlee
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Nature medicine 2003;9(3):294-9.
2001: Xue-Liang Du; Diane Edelstein; S Dimmeler; Qida Ju; C Sui; Michael Brownlee
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site.
The Journal of clinical investigation 2001;108(9):1341-8.
2001: Anders H Berg; Terry P Combs; Xue-Liang Du; Michael Brownlee; Philipp E Scherer
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.
Nature medicine 2001;7(8):947-53.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Y Kaneda; M Guzmán; Michael Brownlee
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A.
The Journal of biological chemistry 2001;276(27):25096-100.
2001: SI Yamagishi; Diane Edelstein; Xue-Liang Du; Michael Brownlee
Hyperglycemia potentiates collagen-induced platelet activation through mitochondrial superoxide overproduction.
Diabetes 2001;50(6):1491-4.
2001: P Rösen; Xue-Liang Du; Guangzhi Sui
Molecular mechanisms of endothelial dysfunction in the diabetic heart.
Advances in experimental medicine and biology 2001;498():75-86.
2000: Xue-Liang Du; Diane Edelstein; L Rossetti; I George Fantus; Howard Goldberg; F Ziyadeh; J Wu; Michael Brownlee
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12222-6.
2000: T Nishikawa; Diane Edelstein; Xue-Liang Du; SI Yamagishi; Takeshi Matsumura; Y Kaneda; M A Yorek; D Beebe; Peter Oates; Hans-Peter Hammes; Ida Giardino; Michael Brownlee
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage.
Nature 2000;404(6779):787-90.
1999: Xue-Liang Du; K Stocklauser-Färber; P Rösen
Generation of reactive oxygen intermediates, activation of NF-kappaB, and induction of apoptosis in human endothelial cells by glucose: role of nitric oxide synthase?
Free radical biology & medicine 1999;27(7-8):752-63.
1998: P Rösen; Xue-Liang Du; D Tschöpe
Role of oxygen derived radicals for vascular dysfunction in the diabetic heart: prevention by alpha-tocopherol?
Molecular and cellular biochemistry 1998;188(1-2):103-11.
1998: Xue-Liang Du; Guangzhi Sui; K Stockklauser-Färber; J Weiss; S Zink; B Schwippert; Q X Wu; D Tschöpe; P Rösen
Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species.
Diabetologia 1998;41(3):249-56.