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Andrei Thomas-Tikhonenko

Research Profile

Living Beings

Physiology

Chemicals & Drugs

Genes & Molecular Sequences

Genes, myc

Anatomy

Disorders

Concepts & Ideas

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Publications

TOP 3
Jamie L Fox; Andy J Minn; Michael Dews; Andrei Thomas-Tikhonenko
Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.
Lori S Hart; Albert Koong; Meixia Bi; George Cerniglia; John T Cunningham; Tatini Datta; Souvik Dey; J Alan Diehl; Serge Y Fuchs; Yan Gao; Stacey L Lehman; Changhong Li; Yan Li; Huayi Liu; Amit Maity; Ian G Mills; Alexander E Perl; Bo Qiu; Davide Ruggero; Feven Tameire; Andrei Thomas-Tikhonenko; Haiyan Zhang; Constantinos Koumenis
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
Elaine Y Chung; Yimei Li; James N Psathas; Mitchell J Weiss; Duonan Yu; Andrei Thomas-Tikhonenko
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.

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All Publications

2013: Jamie L Fox; Andy J Minn; Michael Dews; Andrei Thomas-Tikhonenko
Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.
RNA (New York, N.Y.) 2013;19(2):177-90.
2012: Lori S Hart; Albert Koong; Meixia Bi; George Cerniglia; John T Cunningham; Tatini Datta; Souvik Dey; J Alan Diehl; Serge Y Fuchs; Yan Gao; Stacey L Lehman; Changhong Li; Yan Li; Huayi Liu; Amit Maity; Ian G Mills; Alexander E Perl; Bo Qiu; Davide Ruggero; Feven Tameire; Andrei Thomas-Tikhonenko; Haiyan Zhang; Constantinos Koumenis
ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.
The Journal of clinical investigation 2012;122(12):4621-34.
2012: Elaine Y Chung; Yimei Li; James N Psathas; Mitchell J Weiss; Duonan Yu; Andrei Thomas-Tikhonenko
CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.
The Journal of clinical investigation 2012;122(6):2257-66.
2011: Xiao-Yong Zhang; Renato Baserga; Lewis A Chodosh; Alpana Kumari; Hestia S Mellert; Graham Packham; Harla K Pfeiffer; Isidore Rigoutsos; Hans E Seidel; Timothy J Stanek; Robyn T Sussman; Andrei Thomas-Tikhonenko; Duonan Yu; Steven B McMahon
Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC.
Molecular and cellular biology 2011;31(24):5037-45.
2011: Elena Sotillo; Andrei Thomas-Tikhonenko
The long reach of noncoding RNAs.
Nature genetics 2011;43(7):616-7.
2011: Elena Sotillo; Andrei Thomas-Tikhonenko
Shielding the messenger (RNA): microRNA-based anticancer therapies.
Pharmacology & therapeutics 2011;131(1):18-32.
2011: E Sotillo; T Laver; H Mellert; J M Schelter; M A Cleary; S McMahon; Andrei Thomas-Tikhonenko
Myc overexpression brings out unexpected antiapoptotic effects of miR-34a.
Oncogene 2011;30(22):2587-94.
2010: Pieter Mestdagh; Anna-Karin Boström; Francis Impens; Erik Fredlund; Gert Van Peer; Pasqualino De Antonellis; Kristoffer von Stedingk; Bart Ghesquière; Stefanie Schulte; Michael Dews; Andrei Thomas-Tikhonenko; Johannes H Schulte; Massimo Zollo; Alexander Schramm; Kris Gevaert; Håkan Axelson; Frank Speleman; Jo Vandesompele
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma.
Molecular cell 2010;40(5):762-73.
2010: Michael Dews; Jamie L Fox; Stacy Hultine; Prema Sundaram; Wenge Wang; Yingqiu Y Liu; Emma Furth; Gregory H Enders; Wafik El-Deiry; Janell M Schelter; Michele A Cleary; Andrei Thomas-Tikhonenko
The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors.
Cancer research 2010;70(20):8233-46.
2009: Olesya Chayka; Daisy Corvetta; Michael Dews; Alessandro E Caccamo; Izabela Piotrowska; Giorgia Santilli; Sian Gibson; Neil J Sebire; Nourredine Himoudi; Michael D Hogarty; John Anderson; Saverio Bettuzzi; Andrei Thomas-Tikhonenko; Arturo Sala
Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.
Journal of the National Cancer Institute 2009;101(9):663-77.
2009: Tsung-Cheng Chang; Lauren R Zeitels; Hun-Way Hwang; Raghu R Chivukula; Erik A Wentzel; Michael Dews; Jason Jung; Ping Gao; Chi Dang; MICHAEL BEER; Andrei Thomas-Tikhonenko; Joshua T Mendell
Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3384-9.
2009: Arturo Sala; Saverio Bettuzzi; Sabina Pucci; Olesya Chayka; Michael Dews; Andrei Thomas-Tikhonenko
Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.
Advances in cancer research 2009;105():115-32.
2008: Elaine Y Chung; Michael Dews; Diana Cozma; Duonan Yu; Erik A Wentzel; Tsung-Cheng Chang; Janell M Schelter; Michele A Cleary; Joshua T Mendell; Andrei Thomas-Tikhonenko
c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.
Cancer biology & therapy 2008;7(11):1758-64.
2008: Andrei Thomas-Tikhonenko; Diana Cozma
PAX5 and B-cell neoplasms: transformation through presentation.
Future oncology (London, England) 2008;4(1):5-9.
2008: Tsung-Cheng Chang; Duonan Yu; Yun-Sil Lee; Erik A Wentzel; Dan E Arking; Kristin M West; Chi Dang; Andrei Thomas-Tikhonenko; Joshua T Mendell
Widespread microRNA repression by Myc contributes to tumorigenesis.
Nature genetics 2008;40(1):43-50.
2007: Saravanan Thiyagarajan; Neehar Bhatia; Shannon Reagan-Shaw; Diana Cozma; Andrei Thomas-Tikhonenko; Nihal Ahmad; Vladimir S Spiegelman
Role of GLI2 transcription factor in growth and tumorigenicity of prostate cells.
Cancer research 2007;67(22):10642-6.
2007: K G Suresh Kumar; Jianghuai Liu; Ying Li; Duonan Yu; Andrei Thomas-Tikhonenko; Meenhard Herlyn; Serge Y Fuchs
Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.
Cancer biology & therapy 2007;6(9):1437-41.
2007: Diana Cozma; Duonan Yu; Suchita Hodawadekar; Anna Azvolinsky; Shannon M Grande; John W Tobias; Michele H Metzgar; Jennifer Paterson; Jan Erikson; Teresa Marafioti; John G Monroe; Michael L Atchison; Andrei Thomas-Tikhonenko
B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling.
The Journal of clinical investigation 2007;117(9):2602-10.
2007: Duonan Yu; Martin Carroll; Andrei Thomas-Tikhonenko
p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors.
Blood 2007;109(11):4936-43.
2007: Elaine Y Chung; Michael Dews; Amit Maity; Andrei Thomas-Tikhonenko
Aiding and ABT'ing Treatment for Glioblastoma.
Cancer biology & therapy 2007;6(5):802-4.
2007: Jianghuai Liu; K G Suresh Kumar; Duonan Yu; S A Molton; M McMahon; Meenhard Herlyn; Andrei Thomas-Tikhonenko; Serge Y Fuchs
Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells.
Oncogene 2007;26(13):1954-8.
2007: Ravi K Amaravadi; Duonan Yu; Julian J Lum; Thi Bui; Maria A Christophorou; Gerard I Evan; Andrei Thomas-Tikhonenko; Craig Thompson
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma.
The Journal of clinical investigation 2007;117(2):326-36.
2007: Suchita Hodawadekar; Duonan Yu; Diana Cozma; Bruce Freedman; Oriol Sunyer; Michael L Atchison; Andrei Thomas-Tikhonenko
B-Lymphoma cells with epigenetic silencing of Pax5 trans-differentiate into macrophages, but not other hematopoietic lineages.
Experimental cell research 2007;313(2):331-40.
2006: Suchita Hodawadekar; Fang Wei; Duonan Yu; Andrei Thomas-Tikhonenko; Michael L Atchison
Epigenetic histone modifications do not control Igkappa locus contraction and intranuclear localization in cells with dual B cell-macrophage potential.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):6165-71.
2006: Michael Dews; Asal Homayouni; Duonan Yu; Danielle A. Murphy; Cinzia Sevignani; Erik A Wentzel; Emma E Furth; William M Lee; Greg H Enders; Joshua T Mendell; Andrei Thomas-Tikhonenko
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Nature genetics 2006;38(9):1060-5.
2006: Diana Cozma; Andrei Thomas-Tikhonenko
Kit-activating mutations in AML: lessons from PU.1-induced murine erythroleukemia.
Cancer biology & therapy 2006;5(6):579-81.
2006: Kathryn A O'Donnell; Duonan Yu; Karen I Zeller; Jung-Whan Kim; Frederick Racke; Andrei Thomas-Tikhonenko; Chi Dang
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.
Molecular and cellular biology 2006;26(6):2373-86.
2006: Jessica Bertout; Andrei Thomas-Tikhonenko
Infection & neoplastic growth 101: the required reading for microbial pathogens aspiring to cause cancer.
Cancer treatment and research 2006;130():167-97.
2005: Duonan Yu; Diana Cozma; Andrea Park; Andrei Thomas-Tikhonenko
Functional validation of genes implicated in lymphomagenesis: an in vivo selection assay using a Myc-induced B-cell tumor.
Annals of the New York Academy of Sciences 2005;1059():145-59.
2005: Xiao-Yong Zhang; Lauren M DeSalle; Jagruti H Patel; Anthony John Capobianco; Duonan Yu; Andrei Thomas-Tikhonenko; Steven B McMahon
Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13968-73.
2005: Duonan Yu; Michael Dews; Andrea Park; John W Tobias; Andrei Thomas-Tikhonenko
Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies.
Cancer research 2005;65(12):5454-61.
2005: Weigang Tang; Ying Li; Duonan Yu; Andrei Thomas-Tikhonenko; Vladimir S Spiegelman; Serge Y Fuchs
Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells.
Cancer research 2005;65(5):1904-8.
2004: M Stacey Ricci; Zhaoyu Jin; Michael Dews; Duonan Yu; Andrei Thomas-Tikhonenko; David T Dicker; Wafik S El-Deiry
Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity.
Molecular and cellular biology 2004;24(19):8541-55.
2004: Kristen Johnson; David L Pflugh; Duonan Yu; David G T Hesslein; Kuo-I Lin; Alfred L M Bothwell; Andrei Thomas-Tikhonenko; David G Schatz; Kathryn Calame
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Nature immunology 2004;5(8):853-61.
2004: Andrei Thomas-Tikhonenko; Isabelle Viard-Leveugle; Michael Dews; Philippe Wehrli; Cinzia Sevignani; Duonan Yu; Stacey Ricci; Wafik S El-Deiry; Bruce Aronow; Gürkan Kaya; Jean-Hilaire Saurat; Lars E French
Myc-transformed epithelial cells down-regulate clusterin, which inhibits their growth in vitro and carcinogenesis in vivo.
Cancer research 2004;64(9):3126-36.
2004: Andrei Thomas-Tikhonenko; M Luisa Iruela-Arispe
Whence thrombospondin?
Cancer biology & therapy 2004;3(4):406-7.
2003: Erinn B Rankin; Duonan Yu; Jiu Jiang; Hao Shen; Edward J Pearce; Michael H Goldschmidt; David E Levy; Tatyana V Golovkina; Christopher A Hunter; Andrei Thomas-Tikhonenko
An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth.
Cancer biology & therapy 2003;2(6):687-93.
2003: Duonan Yu; David Allman; Michael H Goldschmidt; Michael L Atchison; John G Monroe; Andrei Thomas-Tikhonenko
Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway.
Blood 2003;101(5):1950-5.
2003: Andrei Thomas-Tikhonenko; Christopher A Hunter
Infection and cancer: the common vein.
Cytokine & growth factor reviews 2003;14(1):67-77.
2002: Andrei Thomas-Tikhonenko
Poisoning the messengers: could tumor endothelial cells acquire drug resistance?
Cancer biology & therapy 2002;1(3):266-7.
2002: Duonan Yu; Andrei Thomas-Tikhonenko
A non-transgenic mouse model for B-cell lymphoma: in vivo infection of p53-null bone marrow progenitors by a Myc retrovirus is sufficient for tumorigenesis.
Oncogene 2002;21(12):1922-7.
2001: Duonan Yu; Andrei Thomas-Tikhonenko
Intratumoral delivery of an interferon gamma retrovirus-producing cells inhibits growth of a murine melanoma by a non-immune mechanism.
Cancer letters 2001;173(2):145-54.
2001: Christopher A Hunter; Duonan Yu; Michael S Gee; CV Ngo; Cinzia Sevignani; Michael H Goldschmidt; Tatyana V Golovkina; S Evans; W F Lee; Andrei Thomas-Tikhonenko
Cutting edge: systemic inhibition of angiogenesis underlies resistance to tumors during acute toxoplasmosis.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):5878-81.
2000: A Janz; Cinzia Sevignani; K Kenyon; CV Ngo; Andrei Thomas-Tikhonenko
Activation of the myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA.
Nucleic acids research 2000;28(11):2268-75.
2000: CV Ngo; Michael S Gee; N Akhtar; Duonan Yu; Olga V Volpert; R Auerbach; Andrei Thomas-Tikhonenko
An in vivo function for the transforming Myc protein: elicitation of the angiogenic phenotype.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(4):201-10.
1996: Andrei Thomas-Tikhonenko; D J Black; Maxine L Linial
Viral Myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1, a possible tumor suppressor gene.
The Journal of biological chemistry 1996;271(48):30741-7.
1995: Andrei Thomas-Tikhonenko; D J Black; Maxine L Linial
v-Myc is invariably required to sustain rapid proliferation of infected cells but in stable cell lines becomes dispensable for other traits of the transformed phenotype.
Oncogene 1995;11(8):1499-508.
1993: Andrei Thomas-Tikhonenko; A R Hartman; Maxine L Linial
Overproduction of v-Myc in the nucleus and its excess over Max are not required for avian fibroblast transformation.
Molecular and cellular biology 1993;13(6):3623-31.
1993: Andrei Thomas-Tikhonenko; Maxine L Linial
Transforming variants of the avian myc-containing retrovirus FH3 arise prior to phenotypic selection.
Journal of virology 1993;67(6):3635-8.
1992: Andrei Thomas-Tikhonenko; Maxine L Linial
gag as well as myc sequences contribute to the transforming phenotype of the avian retrovirus FH3.
Journal of virology 1992;66(2):946-55.
1991: Andrei Thomas-Tikhonenko; A V Polotskaya; N S Vassetzky; Tatyana V Golovkina; Andrei V Gudkov
Long terminal repeats of dwarf hamster endogenous retrovirus are highly diverged and do not maintain efficient transcription.
Virology 1991;181(1):367-70.
1990: Tatyana V Golovkina; Andrei Thomas-Tikhonenko; N S Vassetzky; B I Sheftel; Andrei V Gudkov
Distribution of mouse mammary tumor virus-related sequences does not correlate with the taxonomic position of their hosts.
Virus genes 1990;4(1):85-92.
1990: Andrei Thomas-Tikhonenko; N S Vassetzky; Tatyana V Golovkina; Andrei V Gudkov
Molecular cloning and primary structure analysis of the mouse mammary tumor virus-related element from dwarf hamster genome.
Virus genes 1990;3(3):259-61.
1990: Andrei Thomas-Tikhonenko; O L Lomovskaya
Avian endogenous provirus (ev-3) env gene sequencing: implication for pathogenic retrovirus origination.
Virus genes 1990;3(3):251-8.
1990: Tatyana V Golovkina; Andrei Thomas-Tikhonenko; N S Vasetskiĭ; B I Sheftel'; Andrei V Gudkov
[Sequences homologous to mouse mammary cancer virus are common in mammalian and avian genomes].
Molekuliarnaia biologiia 1990;24(1):127-33.
1989: N S Vasetskiĭ; Andrei Thomas-Tikhonenko; Tatyana V Golovkina; Andrei V Gudkov
[Cloning and analysis of the primary structure of an element, related to the murine mammary cancer virus, from the genome of the Djungarian hamster].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1989;(10):16-9.
1987: Andrei Thomas-Tikhonenko; Andrei V Gudkov
[Endogenous proretroviruses and other autonomous retroposons: traces of viral origin or decay?].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(7):3-11.
1987: Mikhail V Chernov; Andrei Thomas-Tikhonenko; T E Zaĭtsevskaia; R A Denisova; I B Obukh
[The genome of chickens free of endogenous avian leukosis-sarcoma proviruses contains sequences distantly related to Rous sarcoma virus].
Molekuliarnaia genetika, mikrobiologiia i virusologiia 1987;(3):6-11.
1986: Andrei V Gudkov; Mikhail V Chernov; Andrei Thomas-Tikhonenko; I B Obukh; I Hlozánek
Methylation of endogenous proviruses of Brown Leghorn chickens.
Folia biologica 1986;32(1):73-7.
1986: Andrei V Gudkov; E Korec; Mikhail V Chernov; Andrei Thomas-Tikhonenko; I B Obukh; I Hlozánek
Genetic structure of the endogenous proviruses and expression of the gag gene in Brown Leghorn chickens.
Folia biologica 1986;32(1):65-72.
1985: Andrei Thomas-Tikhonenko; Mikhail V Chernov; I B Obukh; Andrei V Gudkov
[Possible mechanisms of the occurrence of new loci of defective endogenous proviruses].
Doklady Akademii nauk SSSR 1985;282(5):1259-62.