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Graeme Dougherty

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Graeme Dougherty; S T Dougherty
Exploiting the tumor microenvironment in the development of targeted cancer gene therapy.
Graeme Dougherty; Peter D Davis; Shona T Dougherty
Vascular-targeted cancer gene therapy.
Gregory M Hayes; Shona T Dougherty; Peter D Davis; Graeme Dougherty
Molecular mechanisms regulating the tumor-targeting potential of splice-activated gene expression.

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All Publications

2009: Graeme Dougherty; S T Dougherty
Exploiting the tumor microenvironment in the development of targeted cancer gene therapy.
Cancer gene therapy 2009;16(3):279-90.
2004: Graeme Dougherty; Peter D Davis; Shona T Dougherty
Vascular-targeted cancer gene therapy.
Expert opinion on biological therapy 2004;4(12):1911-20.
2004: Gregory M Hayes; Shona T Dougherty; Peter D Davis; Graeme Dougherty
Molecular mechanisms regulating the tumor-targeting potential of splice-activated gene expression.
Cancer gene therapy 2004;11(12):797-807.
2004: william mcbride; Chi-Shiun Chiang; Jennifer L Olson; Chun-Chieh Wang; Ji-Hong Hong; Frank Pajonk; Graeme Dougherty; Keisuke S Iwamoto; Milena Pervan; Yu-Pei Liao
A sense of danger from radiation.
Radiation research 2004;162(1):1-19.
2004: Young-Taek Oh; Daniel W C Chen; Graeme Dougherty; william mcbride
Adenoviral interleukin-3 gene-radiation therapy for prostate cancer in mouse model.
International journal of radiation oncology, biology, physics 2004;59(2):579-83.
2002: Gregory M Hayes; Roland Chiu; Carmine Carpenito; Shona T Dougherty; Graeme Dougherty
Identification of sequence motifs responsible for the adhesive interaction between exon v10-containing CD44 isoforms.
The Journal of biological chemistry 2002;277(52):50529-34.
2002: Peter D Davis; Graeme Dougherty; David C Blakey; Susan M Galbraith; Gillian M Tozer; Angela L Holder; Matthew A Naylor; John Nolan; Michael R L Stratford; David J Chaplin; Sally A Hill
ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature.
Cancer research 2002;62(24):7247-53.
2002: Carmine Carpenito; Peter D Davis; Shona T Dougherty; Graeme Dougherty
Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapy-based approach to the treatment of cancer.
International journal of radiation oncology, biology, physics 2002;54(5):1473-8.
2002: Gregory M Hayes; Carmine Carpenito; Peter D Davis; Shona T Dougherty; Julie F Dirks; Graeme Dougherty
Alternative splicing as a novel of means of regulating the expression of therapeutic genes.
Cancer gene therapy 2002;9(2):133-41.
2001: Mariam Dohadwala; Jie Luo; Li Zhu; Ying Lin; Graeme Dougherty; Sherven Sharma; Min Huang; Mehis Pold; Raj K Batra; Steven M Dubinett
Non-small cell lung cancer cyclooxygenase-2-dependent invasion is mediated by CD44.
The Journal of biological chemistry 2001;276(24):20809-12.
2000: Y Z Wu; Ji-Hong Hong; H H Huang; Graeme Dougherty; william mcbride; Chi-Shiun Chiang
Mechanisms mediating the effects of IL-3 gene expression on tumor growth.
Journal of leukocyte biology 2000;68(6):890-6.
2000: Chi-Shiun Chiang; Ji-Hong Hong; Y C Wu; william mcbride; Graeme Dougherty
Combining radiation therapy with interleukin-3 gene immunotherapy.
Cancer gene therapy 2000;7(8):1172-8.
1999: R K Chiu; Carmine Carpenito; Shona T Dougherty; Gregory M Hayes; Graeme Dougherty
Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44.
Neoplasia (New York, N.Y.) 1999;1(5):446-52.
1999: David J Chaplin; Graeme Dougherty
Tumour vasculature as a target for cancer therapy.
British journal of cancer 1999;80 Suppl 1():57-64.
1999: S Ghaffari; F Smadja-Joffe; Robert Oostendorp; J P Lévesque; Graeme Dougherty; Allen Eaves; Connie Eaves
CD44 isoforms in normal and leukemic hematopoiesis.
Experimental hematology 1999;27(6):978-93.
1999: Mladen Korbelik; Graeme Dougherty
Photodynamic therapy-mediated immune response against subcutaneous mouse tumors.
Cancer research 1999;59(8):1941-6.
1999: R K Chiu; A Droll; Shona T Dougherty; Carmine Carpenito; D L Cooper; Graeme Dougherty
Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44.
Experimental cell research 1999;248(1):314-21.
1999: Ronald W Pero; B Axelsson; D Siemann; D Chaplin; Graeme Dougherty
Newly discovered anti-inflammatory properties of the benzamides and nicotinamides.
Molecular and cellular biochemistry 1999;193(1-2):119-25.
1998: Guitta Maki; Gerald Krystal; Graeme Dougherty; Fumio Takei; Hans G Klingemann
Induction of sensitivity to NK-mediated cytotoxicity by TNF-alpha treatment: possible role of ICAM-3 and CD44.
Leukemia 1998;12(10):1565-72.
1998: N L Cooper; P Bardy; J Bacani; U Kuusk; Graeme Dougherty; Connie J Eaves; Joanne T Emerman
Correlation of CD44 expression with proliferative activity of normal human breast epithelial cells in culture.
Breast cancer research and treatment 1998;50(2):143-53.
1998: HM Schrager; Sebastián Albertí; Colette Cywes; Graeme Dougherty; Michael R Wessels
Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes.
The Journal of clinical investigation 1998;101(8):1708-16.
1997: Chi-Shiun Chiang; R G Syljuäsen; Ji-Hong Hong; A Wallis; Graeme Dougherty; william mcbride
Effects of IL-3 gene expression on tumor response to irradiation in vitro and in vivo.
Cancer research 1997;57(18):3899-903.
1997: C Luo; Susan H MacPhail; Graeme Dougherty; C C Naus; Peggy L Olive
Radiation response of connexin43-transfected cells in relation to the "contact effect".
Experimental cell research 1997;234(2):225-32.
1997: Simon P Hart; Graeme Dougherty; Christopher Haslett; Ian Dransfield
CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):919-25.
1997: Shona T Dougherty; Connie J Eaves; william mcbride; Graeme Dougherty
Role of macrophage-colony-stimulating factor in regulating the accumulation and phenotype of tumor-associated macrophages.
Cancer immunology, immunotherapy : CII 1997;44(3):165-72.
1997: S Ghaffari; Graeme Dougherty; Allen Eaves; Connie J Eaves
Diverse effects of anti-CD44 antibodies on the stromal cell-mediated support of normal but not leukaemic (CML) haemopoiesis in vitro.
British journal of haematology 1997;97(1):22-8.
1997: Lawrence D Mayer; Graeme Dougherty; Troy O Harasym; Marcel B Bally
The role of tumor-associated macrophages in the delivery of liposomal doxorubicin to solid murine fibrosarcoma tumors.
The Journal of pharmacology and experimental therapeutics 1997;280(3):1406-14.
1997: Gabi U Dachs; Graeme Dougherty; I J Stratford; David J Chaplin
Targeting gene therapy to cancer: a review.
Oncology research 1997;9(6-7):313-25.
1997: Shona T Dougherty; Connie J Eaves; william mcbride; Graeme Dougherty
Molecular mechanisms regulating TNF-alpha production by tumor-associated macrophages.
Cancer letters 1997;111(1-2):27-37.
1996: Mladen Korbelik; G Krosl; Jana Krosl; Graeme Dougherty
The role of host lymphoid populations in the response of mouse EMT6 tumor to photodynamic therapy.
Cancer research 1996;56(24):5647-52.
1996: S Ghaffari; Graeme Dougherty; Allen Eaves; C J Eaves
Altered patterns of CD44 epitope expression in human chronic and acute myeloid leukemia.
Leukemia 1996;10(11):1773-81.
1996: C Fehlner-Gardiner; Shashi Uniyal; Christoph Ballestrem; Graeme Dougherty; Bosco M C Chan
Integrin VLA-6 (alpha 6 beta 1) mediates adhesion of mouse bone marrow-derived mast cells to laminin.
Allergy 1996;51(9):650-6.
1996: G Krosl; Mladen Korbelik; Jana Krosl; Graeme Dougherty
Potentiation of photodynamic therapy-elicited antitumor response by localized treatment with granulocyte-macrophage colony-stimulating factor.
Cancer research 1996;56(14):3281-6.
1996: william mcbride; James S Economou; R G Syljuåsen; C Parrish; D Hackman; V Latham; C S Chiang; Graeme Dougherty
The effects of cytokine gene transfer into tumors on host cell infiltration and regression.
Anticancer research 1996;16(3A):1139-43.
1996: H G Klingemann; Graeme Dougherty
Site-specific delivery of cytokines in cancer.
Molecular medicine today 1996;2(4):154-9.
1995: D C Asman; J F Dirks; L Ge; N M Resnick; L A Salvucci; J T Gau; Michael Becich; D L Cooper; Graeme Dougherty
Gene therapeutic approach to primary and metastatic brain tumors: I. CD44 variant pre-RNA alternative splicing as a CEPT control element.
Journal of neuro-oncology 1995;26(3):243-50.
1995: R K Chiu; A Droll; D L Cooper; Shona T Dougherty; J F Dirks; Graeme Dougherty
Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44.
Journal of neuro-oncology 1995;26(3):231-9.
1995: william mcbride; Graeme Dougherty
Radiotherapy for genes that cause cancer.
Nature medicine 1995;1(11):1215-7.
1995: S Ghaffari; Graeme Dougherty; Peter M Lansdorp; Allen Eaves; C J Eaves
Differentiation-associated changes in CD44 isoform expression during normal hematopoiesis and their alteration in chronic myeloid leukemia.
Blood 1995;86(8):2976-85.
1995: MR Clarke; Rodney J Landreneau; Neil M Resnick; Rebecca S Crowley; Graeme Dougherty; D L Cooper; Samuel A Yousem
Prognostic significance of CD44 expression in adenocarcinoma of the lung.
Clinical molecular pathology 1995;48(4):M200-4.
1995: D L Cooper; Graeme Dougherty
To metastasize or not? Selection of CD44 splice sites.
Nature medicine 1995;1(7):635-7.
1995: A Droll; Shona T Dougherty; R K Chiu; J F Dirks; william mcbride; D L Cooper; Graeme Dougherty
Adhesive interactions between alternatively spliced CD44 isoforms.
The Journal of biological chemistry 1995;270(19):11567-73.
1995: Steven M Dubinett; Min Huang; S Dhanani; James S Economou; J Wang; P Lee; Sherven Sharma; Graeme Dougherty; william mcbride
Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7.
Journal of the National Cancer Institute 1995;87(8):593-7.
1995: G Krosl; Mladen Korbelik; Graeme Dougherty
Induction of immune cell infiltration into murine SCCVII tumour by photofrin-based photodynamic therapy.
British journal of cancer 1995;71(3):549-55.
1995: william mcbride; James S Economou; N Kuber; J H Hong; C S Chiang; R Syljuasen; S T Dougherty; Graeme Dougherty
Modification of tumor microenvironment by cytokine gene transfer.
Acta oncologica (Stockholm, Sweden) 1995;34(3):447-51.
1994: T Kühr; Graeme Dougherty; H G Klingemann
Transfer of the tumor necrosis factor alpha gene into hematopoietic progenitor cells as a model for site-specific cytokine delivery after marrow transplantation.
Blood 1994;84(9):2966-70.
1994: Graeme Dougherty; J D Thacker; R S Lavey; A Belldegrun; william mcbride
Inhibitory effect of locally produced and exogenous interleukin-6 on tumor growth in vivo.
Cancer immunology, immunotherapy : CII 1994;38(5):339-45.
1994: L Finn; Graeme Dougherty; G Finley; A Meisler; Michael Becich; D L Cooper
Alternative splicing of CD44 pre-mRNA in human colorectal tumors.
Biochemical and biophysical research communications 1994;200(2):1015-22.
1994: Graeme Dougherty; D L Cooper; J F Memory; R K Chiu
Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1.
The Journal of biological chemistry 1994;269(12):9074-8.
1993: A R Miller; william mcbride; Steven M Dubinett; Graeme Dougherty; J D Thacker; H Shau; D B Kohn; R C Moen; M J Walker; Robert Chiu
Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2.
Blood 1993;82(12):3686-94.
1993: J R Vielkind; Victor A Tron; B M Schmidt; Graeme Dougherty; Vincent C Ho; B W Woolcock; B Sadaghiani; C J Smith
A putative marker for human melanoma. A monoclonal antibody derived from the melanoma gene in the Xiphophorus melanoma model.
The American journal of pathology 1993;143(3):656-62.
1992: william mcbride; J D Thacker; S Comora; James S Economou; D Kelley; Donna E Hogge; Steven M Dubinett; Graeme Dougherty
Genetic modification of a murine fibrosarcoma to produce interleukin 7 stimulates host cell infiltration and tumor immunity.
Cancer research 1992;52(14):3931-7.
1992: D L Cooper; Graeme Dougherty; Horng-Jyh Harn; S Jackson; E W Baptist; J Byers; A Datta; G Phillips; N R Isola
The complex CD44 transcriptional unit; alternative splicing of three internal exons generates the epithelial form of CD44.
Biochemical and biophysical research communications 1992;182(2):569-78.
1991: Graeme Dougherty; P M Landorp; D L Cooper; R K Humphries
Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte "homing" receptor expressed by hemopoietic cells.
The Journal of experimental medicine 1991;174(1):1-5.
1991: C J Eaves; Johanne Cashman; Robert J Kay; Graeme Dougherty; T Otsuka; L A Gaboury; Donna E Hogge; Peter M Lansdorp; Allen Eaves; R Keith Humphries
Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer.
Blood 1991;78(1):110-7.
1990: H Sutherland; Graeme Dougherty; S Dedhar
Developmental biology and oncology: two sides to the same coin? Sixth International Conference on the Differentiation of Normal and Neoplastic Cells sponsored by the International Society of Differentiation and the Canadian Society for Cellular and Molecular Biology, Vancouver, B.C., Canada, July 29-August 2, 1990.
The New biologist 1990;2(11):970-3.
1990: R Kay; Graeme Dougherty; R Keith Humphries
Heterogeneous modifications of the 114/A10 protein of interleukin-3-dependent cells are concentrated in a highly repetitive amino-terminal domain.
The Journal of biological chemistry 1990;265(9):4962-8.
1989: Graeme Dougherty; S T Dougherty; Robert J Kay; P Landsdorp; R Keith Humphries
Identification and characterization of 114/A10, an antigen highly expressed on the surface of murine myeloid and erythroid progenitor cells and IL-3-dependent cell lines.
Experimental hematology 1989;17(8):877-82.
1989: Graeme Dougherty; Robert J Kay; R Keith Humphries
Molecular cloning of 114/A10, a cell surface antigen containing highly conserved repeated elements, which is expressed by murine hemopoietic progenitor cells and interleukin-3-dependent cell lines.
The Journal of biological chemistry 1989;264(11):6509-14.
1988: Graeme Dougherty; Ian Dransfield; Nancy Hogg
Identification of a novel monocyte cell surface molecule involved in the generation of antigen-induced proliferative responses.
European journal of immunology 1988;18(12):2067-71.
1988: Graeme Dougherty; S Murdoch; Nancy Hogg
The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response.
European journal of immunology 1988;18(1):35-9.
1987: Graeme Dougherty; Y Selvendran; S Murdoch; D G Palmer; Nancy Hogg
The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.
European journal of immunology 1987;17(10):1453-9.
1987: Graeme Dougherty; N Hogg
The role of monocyte lymphocyte function-associated antigen 1 (LFA-1) in accessory cell function.
European journal of immunology 1987;17(7):943-7.
1986: Graeme Dougherty; william mcbride
Accessory cell activity of murine tumor-associated macrophages.
Journal of the National Cancer Institute 1986;76(3):541-8.
1986: Graeme Dougherty; william mcbride
Immunoregulating activity of tumor-associated macrophages.
Cancer immunology, immunotherapy : CII 1986;23(1):67-72.
1986: N Hogg; Y Selvendran; Graeme Dougherty; C Allen
Macrophage antigens and the effect of a macrophage activating factor, interferon-gamma.
Ciba Foundation symposium 1986;118():68-80.
1984: Graeme Dougherty; william mcbride
Macrophage heterogeneity.
Journal of clinical & laboratory immunology 1984;14(1):1-11.