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Allen Spiegel

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Allen Spiegel; Meredith Hawkins
'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?
Allen Spiegel; Steven Libutti
Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors.
Allen Spiegel; Steven Libutti
Future diagnostic and therapeutic trends in endocrine cancers.

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All Publications

2012: Allen Spiegel; Meredith Hawkins
'Personalized medicine' to identify genetic risks for type 2 diabetes and focus prevention: can it fulfill its promise?
Health affairs (Project Hope) 2012;31(1):43-9.
2011: Allen Spiegel; Steven Libutti
Targeted therapies: Good news for advanced-stage pancreatic neuroendocrine tumors.
Nature reviews. Clinical oncology 2011;8(5):258-9.
2010: Allen Spiegel; Steven Libutti
Future diagnostic and therapeutic trends in endocrine cancers.
Seminars in oncology 2010;37(6):691-5.
2010: Allen Spiegel
Commentary: new guidelines for NIH peer review: improving the system or undermining it?
Academic medicine : journal of the Association of American Medical Colleges 2010;85(5):746-8.
2009: H-C Jennifer Shen; Mei He; Anathea Powell; Asha Adem; Dominique Lorang; Charles Heller; Amelia C Grover; Kris Ylaya; Stephen M Hewitt; Stephen J Marx; Allen Spiegel; Steven Libutti
Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
Cancer research 2009;69(5):1858-66.
2008: Allen Spiegel
Albert Einstein College of Medicine.
Academic medicine : journal of the Association of American Medical Colleges 2008;83(5):524.
2008: H-C Jennifer Shen; Jennifer E Rosen; Lauren M Yang; Sharon A Savage; A Lee Burns; Carmen M Mateo; Sunita K Agarwal; Settara C Chandrasekharappa; Allen Spiegel; Francis S Collins; Stephen J Marx; Steven Libutti
Parathyroid tumor development involves deregulation of homeobox genes.
Endocrine-related cancer 2008;15(1):267-75.
2007: Jianxin Hu; Allen Spiegel
Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.
Journal of cellular and molecular medicine 2007;11(5):908-22.
2007: Atsushi Ozawa; Sunita K Agarwal; Carmen Mateo; A Lee Burns; Terri S Rice; Patricia A Kennedy; Caitlin M Quigley; William F Simonds; Lee S Weinstein; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations.
The Journal of clinical endocrinology and metabolism 2007;92(5):1948-51.
2007: Jianxin Hu; Guadalupe Reyes-Cruz; Paul K Goldsmith; Nicole M Gantt; Jeffery L Miller; Allen Spiegel
Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca(2+) receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(4):601-8.
2007: Sunita K Agarwal; Soren Impey; Shannon McWeeney; Peter C Scacheri; Francis S Collins; Richard H Goodman; Allen Spiegel; Stephen J Marx
Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation.
Neoplasia (New York, N.Y.) 2007;9(2):101-7.
2007: Allen Spiegel
Inherited endocrine diseases involving G proteins and G protein-coupled receptors.
Endocrine development 2007;11():133-44.
2007: Nina Wettschureck; EunAh Lee; Steven Libutti; Stefan Offermanns; Pamela Robey; Allen Spiegel
Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):274-80.
2006: aniello Cerrato; Michael Parisi; Sonia Santa Anna; Fanis Missirlis; Siradanahalli Guru; Sunita Agarwal; David Sturgill; Thomas Talbot; Allen Spiegel; Francis S Collins; Settara C Chandrasekharappa; Stephen Marx; Brian Oliver
Genetic interactions between Drosophila melanogaster menin and Jun/Fos.
Developmental biology 2006;298(1):59-70.
2006: Jianxin Hu; Jiankang Jiang; Stefano Costanzi; Craig J Thomas; Wu Yang; Jean H M Feyen; Kenneth Alan Jacobson; Allen Spiegel
A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator.
The Journal of biological chemistry 2006;281(30):21558-65.
2006: Peter C Scacheri; Sean Davis; Duncan T Odom; Gregory E Crawford; Stacie Perkins; Mohamad J Halawi; Sunita K Agarwal; Stephen J Marx; Allen Spiegel; Paul S Meltzer; Francis S Collins
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
PLoS genetics 2006;2(4):e51.
2006: Allen Spiegel; Elizabeth G Nabel
NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health.
Nature medicine 2006;12(1):67-9.
2005: Allen Spiegel; Barbara M Alving
Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.
The American journal of clinical nutrition 2005;82(1 Suppl):211S-214S.
2005: Sunita K Agarwal; Patricia A Kennedy; Peter C Scacheri; Elizabeth A Novotny; Alison Burgess Hickman; aniello Cerrato; T S Rice; J B Moore; S Rao; Youngmi Ji; Carmen Mateo; Steven Libutti; Brian Oliver; Settara C Chandrasekharappa; A Lee Burns; Francis S Collins; Allen Spiegel; Stephen J Marx
Menin molecular interactions: insights into normal functions and tumorigenesis.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(6):369-74.
2005: Jennifer E Rosen; Nick G Costouros; Dominique Lorang; A Lee Burns; H Richard Alexander; Monica C Skarulis; Craig Cochran; James F Pingpank; Stephen J Marx; Allen Spiegel; Steven Libutti
Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas.
Annals of surgical oncology 2005;12(5):412-6.
2005: Allen Spiegel; Elizabeth G Nabel; Nora D Volkow; Story C Landis; Ting-Kai Li
Obesity on the brain.
Nature neuroscience 2005;8(5):552-3.
2005: Jianxin Hu; Stuart J McLarnon; Stefano Mora; Jiankang Jiang; Craig J Thomas; Kenneth Alan Jacobson; Allen Spiegel
A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+.
The Journal of biological chemistry 2005;280(6):5113-20.
2004: Peter C Scacheri; Judy S Crabtree; Alyssa L Kennedy; Gary P Swain; Jerrold M Ward; Stephen J Marx; Allen Spiegel; Francis S Collins
Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(11):872-7.
2004: Allen Spiegel
Focus on hereditary endocrine neoplasia.
Cancer cell 2004;6(4):327-32.
2004: Peter C Scacheri; Alyssa L Kennedy; Koei Chin; Meghan T Miller; J Graeme Hodgson; Joe Gray; Stephen J Marx; Allen Spiegel; Francis S Collins
Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability.
Cancer research 2004;64(19):7039-44.
2004: Sunita K Agarwal; A Lee Burns; Karen E Sukhodolets; Patricia A Kennedy; Victor H Obungu; Alison Burgess Hickman; Michael Mullendore; Ira Whitten; Monica C Skarulis; William F Simonds; Carmen Mateo; Judy S Crabtree; Peter C Scacheri; Youngmi Ji; Elizabeth A Novotny; Lisa Garrett-Beal; Jerrold M Ward; Steven Libutti; H Richard Alexander; aniello Cerrato; Michael J Parisi; Sonia Santa Anna-A; Brian Oliver; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
Molecular pathology of the MEN1 gene.
Annals of the New York Academy of Sciences 2004;1014():189-98.
2004: Jianxin Hu; Stefano Mora; Giovanna Weber; Ilaria Zamproni; Maria Carla Proverbio; Allen Spiegel
Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(4):578-86.
2004: Allen Spiegel; Lee S Weinstein
Inherited diseases involving g proteins and g protein-coupled receptors.
Annual review of medicine 2004;55():27-39.
2003: Steven Libutti; Judy S Crabtree; Dominique Lorang; A Lee Burns; Chiara Mazzanti; Stephen M Hewitt; Sarah O'Connor; Jerrold M Ward; Michael R Emmert-Buck; Alan T Remaley; Marshall Miller; Ewa Turner; H Richard Alexander; Andrew Arnold; Stephen J Marx; Francis S Collins; Allen Spiegel
Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.
Cancer research 2003;63(22):8022-8.
2003: Sunita K Agarwal; Elizabeth A Novotny; Judy S Crabtree; Jonathan B Weitzman; moshe yaniv; A Lee Burns; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(19):10770-5.
2003: Allen Spiegel
Cell signaling. beta-arrestin--not just for G protein-coupled receptors.
Science (New York, N.Y.) 2003;301(5638):1338-9.
2003: Judy S Crabtree; Peter C Scacheri; Jerrold M Ward; Sara R McNally; Gary P Swain; Cristina Montagna; Jeffrey H Hager; Douglas Hanahan; Ulla Edlund; Mark Magnuson; Lisa Garrett-Beal; A Lee Burns; Thomas Ried; Settara C Chandrasekharappa; Stephen J Marx; Allen Spiegel; Francis S Collins
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Molecular and cellular biology 2003;23(17):6075-85.
2003: Jianxin Hu; Allen Spiegel
Naturally occurring mutations of the extracellular Ca2+-sensing receptor: implications for its structure and function.
Trends in endocrinology and metabolism: TEM 2003;14(6):282-8.
2003: Karen E Sukhodolets; Alison Burgess Hickman; Sunita K Agarwal; Maxim V Sukhodolets; Victor H Obungu; Elizabeth A Novotny; Judy S Crabtree; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; A Lee Burns; Stephen J Marx
The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene.
Molecular and cellular biology 2003;23(2):493-509.
2002: Jianxin Hu; Guadalupe Reyes-Cruz; Wangzhong Chen; Kenneth Alan Jacobson; Allen Spiegel
Identification of acidic residues in the extracellular loops of the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+ and a positive allosteric modulator.
The Journal of biological chemistry 2002;277(48):46622-31.
2002: Stephen J Marx; William F Simonds; Sunita K Agarwal; A Lee Burns; Lee S Weinstein; Craig Cochran; Monica C Skarulis; Allen Spiegel; Steven Libutti; H Richard Alexander; Clara C Chen; Richard Chang; Settara C Chandrasekharappa; Francis S Collins
Hyperparathyroidism in hereditary syndromes: special expressions and special managements.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17 Suppl 2():N37-43.
2002: Jianxin Hu; Stefano Mora; Giacomo Colussi; Maria Carla Proverbio; Kendra A Jones; Laura Bolzoni; Maria E De Ferrari; Giovanni Civati; Allen Spiegel
Autosomal dominant hypocalcemia caused by a novel mutation in the loop 2 region of the human calcium receptor extracellular domain.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(8):1461-9.
2001: Guadalupe Reyes-Cruz; Jianxin Hu; Paul K Goldsmith; Peter J Steinbach; Allen Spiegel
Human Ca(2+) receptor extracellular domain. Analysis of function of lobe I loop deletion mutants.
The Journal of biological chemistry 2001;276(34):32145-51.
2001: C Heppner; K Y Bilimoria; Sunita K Agarwal; M Kester; L J Whitty; Siradanahalli Guru; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx; A Lee Burns
The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.
Oncogene 2001;20(36):4917-25.
2001: Peter C Scacheri; Judy S Crabtree; Elizabeth A Novotny; Lisa Garrett-Beal; Amy Chen; Keith Edgemon; Stephen J Marx; Allen Spiegel; Settara C Chandrasekharappa; Francis S Collins
Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice.
Genesis (New York, N.Y. : 2000) 2001;30(4):259-63.
2001: D H Schussheim; Monica C Skarulis; Sunita K Agarwal; William F Simonds; A Lee Burns; Allen Spiegel; Stephen J Marx
Multiple endocrine neoplasia type 1: new clinical and basic findings.
Trends in endocrinology and metabolism: TEM 2001;12(4):173-8.
2001: Jianxin Hu; Guadalupe Reyes-Cruz; Paul K Goldsmith; Allen Spiegel
The Venus's-flytrap and cysteine-rich domains of the human Ca2+ receptor are not linked by disulfide bonds.
The Journal of biological chemistry 2001;276(10):6901-4.
2001: M A Valle; MB Kester; A L Burns; Stephen J Marx; Allen Spiegel; Joseph Shiloach
Production and purification of human menin from Drosophila melanogaster S2 cells using stirred tank reactor.
Cytotechnology 2001;35(2):127-35.
2001: Judy S Crabtree; Peter C Scacheri; Jerrold M Ward; Lisa Garrett-Beal; Michael R Emmert-Buck; Keith Edgemon; Dominique Lorang; Steven Libutti; Settara C Chandrasekharappa; Stephen J Marx; Allen Spiegel; Francis S Collins
A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1118-23.
2001: Siradanahalli Guru; Nijaguna B Prasad; E J Shin; Kirugaval Hemavathy; J Lu; Y Tony Ip; Sunita K Agarwal; Stephen J Marx; Allen Spiegel; Francis S Collins; B Oliver; Settara C Chandrasekharappa
Characterization of a MEN1 ortholog from Drosophila melanogaster.
Gene 2001;263(1-2):31-8.
2000: Stephan U Goebel; Paolo L Peghini; Paul K Goldsmith; Allen Spiegel; Fathia Gibril; Mark Raffeld; Robert T Jensen; Jose Serrano
Expression of the calcium-sensing receptor in gastrinomas.
The Journal of clinical endocrinology and metabolism 2000;85(11):4131-7.
2000: OM Hauache; J Hu; K Ray; R Xie; Kenneth Alan Jacobson; Allen Spiegel
Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors.
Endocrinology 2000;141(11):4156-63.
2000: J I Knapp; C Heppner; Alison Burgess Hickman; A Lee Burns; Settara C Chandrasekharappa; Francis S Collins; Stephen J Marx; Allen Spiegel; Sunita K Agarwal
Identification and characterization of JunD missense mutants that lack menin binding.
Oncogene 2000;19(41):4706-12.
2000: OM Hauache; J Hu; K Ray; Allen Spiegel
Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca2+ receptor activation.
Endocrine 2000;13(1):63-70.
2000: P Manickam; Andreas M Vogel; Sunita K Agarwal; T Oda; Allen Spiegel; Stephen J Marx; Francis S Collins; Brant M Weinstein; Settara C Chandrasekharappa
Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(6):448-54.
2000: J Hu; OM Hauache; Allen Spiegel
Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors.
The Journal of biological chemistry 2000;275(21):16382-9.
2000: Larisa V Debelenko; Jennifer I Swalwell; Michael J Kelley; E Brambilla; P Manickam; Galina Baibakov; Sunita K Agarwal; Allen Spiegel; Stephen J Marx; Settara C Chandrasekharappa; Francis S Collins; William D Travis; Michael R Emmert-Buck
MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma.
Genes, chromosomes & cancer 2000;28(1):58-65.
2000: Allen Spiegel
G protein defects in signal transduction.
Hormone research 2000;53 Suppl 3():17-22.
2000: Paolo Bianco; Mara Riminucci; A Majolagbe; Sergei A Kuznetsov; Michael T Collins; Mahesh H Mankani; Alessandro Corsi; Henry G Bone; Shlomo Wientroub; Allen Spiegel; Larry W Fisher; Pamela Robey
Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):120-8.
2000: Stephan U Goebel; C Heppner; A Lee Burns; Stephen J Marx; Allen Spiegel; Zhengping Zhuang; Irina A Lubensky; Fathia Gibril; Robert T Jensen; Jose Serrano
Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas.
The Journal of clinical endocrinology and metabolism 2000;85(1):116-23.
1999: Steven Libutti; H Richard Alexander; David L Bartlett; Maureen L Sampson; Mark E Ruddel; Monica C Skarulis; Stephen J Marx; Allen Spiegel; W Simmonds; Alan T Remaley
Kinetic analysis of the rapid intraoperative parathyroid hormone assay in patients during operation for hyperparathyroidism.
Surgery 1999;126(6):1145-50; discussion 1150-1.
1999: Yong-Suk Kim; A Lee Burns; Paul K Goldsmith; C Heppner; SY Park; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx
Stable overexpression of MEN1 suppresses tumorigenicity of RAS.
Oncogene 1999;18(43):5936-42.
1999: K Ray; B C Hauschild; Peter J Steinbach; Paul K Goldsmith; OM Hauache; Allen Spiegel
Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca(2+) receptor critical for dimerization. Implications for function of monomeric Ca(2+) receptor.
The Journal of biological chemistry 1999;274(39):27642-50.
1999: Alexander O Vortmeyer; Irina A Lubensky; Monica C Skarulis; G Li; YW Moon; WS Park; R Weil; C Barlow; Allen Spiegel; Stephen J Marx; Zhengping Zhuang
Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 1999;12(9):919-24.
1999: Allen Spiegel
Citation for the 1999 Monsanto Clinical Investigator Lecture Award of the Endocrine Society to Dr. Stephen J. Marx.
Endocrine reviews 1999;20(4):590-1.
1999: Stephen J Marx; Sunita K Agarwal; C Heppner; Yong-Suk Kim; MB Kester; Paul K Goldsmith; Monica C Skarulis; Allen Spiegel; A Lee Burns; Larisa V Debelenko; Zhengping Zhuang; Irina A Lubensky; Lance A Liotta; Michael R Emmert-Buck; Siradanahalli Guru; P Manickam; Judy S Crabtree; Francis S Collins; Settara C Chandrasekharappa
The gene for multiple endocrine neoplasia type 1: recent findings.
Bone 1999;25(1):119-22.
1999: Siradanahalli Guru; Judy S Crabtree; K D Brown; Karen Joyce Dunn; P Manickam; Nijaguna B Prasad; Danny Wangsa; A Lee Burns; Allen Spiegel; Stephen J Marx; William J Pavan; Francis S Collins; Settara C Chandrasekharappa
Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(6):592-6.
1999: Paul K Goldsmith; GF Fan; K Ray; J Shiloach; Peter McPhie; KV Rogers; Allen Spiegel
Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor.
The Journal of biological chemistry 1999;274(16):11303-9.
1999: Allen Spiegel
Hormone resistance caused by mutations in G proteins and G protein-coupled receptors.
Journal of pediatric endocrinology & metabolism : JPEM 1999;12 Suppl 1():303-9.
1999: X M Zhao; OM Hauache; Paul K Goldsmith; R Collins; Allen Spiegel
A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor.
FEBS letters 1999;448(1):180-4.
1999: Adam C Berger; Steven Libutti; David L Bartlett; M G Skarulis; Stephen J Marx; Allen Spiegel; John L Doppman; H Richard Alexander
Heterogeneous gland size in sporadic multiple gland parathyroid hyperplasia.
Journal of the American College of Surgeons 1999;188(4):382-9.
1999: Sunita K Agarwal; Siradanahalli Guru; C Heppner; M R Erdos; R M Collins; SY Park; SK Saggar; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; Stephen J Marx; A Lee Burns
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.
Cell 1999;96(1):143-52.
1999: Stephen J Marx; Sunita K Agarwal; MB Kester; C Heppner; Yong-Suk Kim; Monica C Skarulis; L A James; Paul K Goldsmith; SK Saggar; SY Park; Allen Spiegel; A Lee Burns; Larisa V Debelenko; Zhengping Zhuang; Irina A Lubensky; Lance A Liotta; Michael R Emmert-Buck; Siradanahalli Guru; P Manickam; J Crabtree; M R Erdos; Francis S Collins; Settara C Chandrasekharappa
Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.
Recent progress in hormone research 1999;54():397-438; discussion 438-9.
1999: Mara Riminucci; B Liu; Alessandro Corsi; Andrew Shenker; Allen Spiegel; Pamela Robey; Paolo Bianco
The histopathology of fibrous dysplasia of bone in patients with activating mutations of the Gs alpha gene: site-specific patterns and recurrent histological hallmarks.
The Journal of pathology 1999;187(2):249-58.
1999: C Heppner; M Reincke; Sunita K Agarwal; P Mora; B Allolio; A Lee Burns; Allen Spiegel; Stephen J Marx
MEN1 gene analysis in sporadic adrenocortical neoplasms.
The Journal of clinical endocrinology and metabolism 1999;84(1):216-9.
1998: K Ray; P Clapp; Paul K Goldsmith; Allen Spiegel
Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction.
The Journal of biological chemistry 1998;273(51):34558-67.
1998: GF Fan; K Ray; X M Zhao; Paul K Goldsmith; Allen Spiegel
Mutational analysis of the cysteines in the extracellular domain of the human Ca2+ receptor: effects on cell surface expression, dimerization and signal transduction.
FEBS letters 1998;436(3):353-6.
1998: S Marx; Allen Spiegel; Monica C Skarulis; John L Doppman; Francis S Collins; Lance A Liotta
Multiple endocrine neoplasia type 1: clinical and genetic topics.
Annals of internal medicine 1998;129(6):484-94.
1998: John L Doppman; Monica C Skarulis; R Chang; H Richard Alexander; D Bartlett; Steven Libutti; S J Marx; Allen Spiegel
Hypocalcemic stimulation and nonselective venous sampling for localizing parathyroid adenomas: work in progress.
Radiology 1998;208(1):145-51.
1998: Stephen J Marx; Sunita K Agarwal; MB Kester; C Heppner; Yong-Suk Kim; Michael R Emmert-Buck; Larisa V Debelenko; Irina A Lubensky; Zhengping Zhuang; Siradanahalli Guru; P Manickam; SE Olufemi; Monica C Skarulis; John L Doppman; H Richard Alexander; Lance A Liotta; Francis S Collins; Settara C Chandrasekharappa; Allen Spiegel; A Lee Burns
Germline and somatic mutation of the gene for multiple endocrine neoplasia type 1 (MEN1).
Journal of internal medicine 1998;243(6):447-53.
1998: P Bianco; Sergei A Kuznetsov; Mara Riminucci; Larry W Fisher; Allen Spiegel; Pamela Robey
Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsalpha-mutated skeletal progenitor cells.
The Journal of clinical investigation 1998;101(8):1737-44.
1998: Michael T Collins; Monica C Skarulis; J P Bilezikian; S J Silverberg; Allen Spiegel; S J Marx
Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent.
The Journal of clinical endocrinology and metabolism 1998;83(4):1083-8.
1998: Siradanahalli Guru; Paul K Goldsmith; A Lee Burns; Stephen J Marx; Allen Spiegel; Francis S Collins; Settara C Chandrasekharappa
Menin, the product of the MEN1 gene, is a nuclear protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(4):1630-4.
1998: Michael R Emmert-Buck; Larisa V Debelenko; S Agarwal; MB Kester; P Manickam; Zhengping Zhuang; Siradanahalli Guru; SE Olufemi; A Lee Burns; Settara C Chandrasekharappa; Irina A Lubensky; Lance A Liotta; Monica C Skarulis; Allen Spiegel; Stephen J Marx; Francis S Collins
11q13 allelotype analysis in 27 northern American MEN1 kindreds identifies two distinct founder chromosomes.
Molecular genetics and metabolism 1998;63(2):151-5.
1998: Sunita K Agarwal; Larisa V Debelenko; MB Kester; Siradanahalli Guru; P Manickam; SE Olufemi; Monica C Skarulis; C Heppner; Judy S Crabtree; Irina A Lubensky; Zhengping Zhuang; Yong-Suk Kim; Settara C Chandrasekharappa; Francis S Collins; Lance A Liotta; Allen Spiegel; A Lee Burns; Michael R Emmert-Buck; Stephen J Marx
Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families.
Human mutation 1998;12(2):75-82.
1998: SE Olufemi; J S Green; P Manickam; Siradanahalli Guru; Sunita K Agarwal; MB Kester; Qiong Dong; A Lee Burns; Allen Spiegel; Stephen J Marx; Francis S Collins; Settara C Chandrasekharappa
Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland.
Human mutation 1998;11(4):264-9.
1997: Zhengping Zhuang; S Z Ezzat; Alexander O Vortmeyer; R Weil; E H Oldfield; WS Park; Svetlana Pack; S Huang; Sunita K Agarwal; Siradanahalli Guru; P Manickam; Larisa V Debelenko; MB Kester; SE Olufemi; C Heppner; Judy S Crabtree; A Lee Burns; Allen Spiegel; Stephen J Marx; Settara C Chandrasekharappa; Francis S Collins; Michael R Emmert-Buck; Lance A Liotta; Sylvia Asa; Irina A Lubensky
Mutations of the MEN1 tumor suppressor gene in pituitary tumors.
Cancer research 1997;57(24):5446-51.
1997: K Ray; GF Fan; Paul K Goldsmith; Allen Spiegel
The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction.
The Journal of biological chemistry 1997;272(50):31355-61.
1997: Steven Libutti; David L Bartlett; N T jaskowiak; Monica C Skarulis; Stephen J Marx; Allen Spiegel; Douglas L Fraker; John L Doppman; T J Shawker; H Richard Alexander
The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism.
Surgery 1997;122(6):1183-7; discussion 1187-8.
1997: Mara Riminucci; Larry W Fisher; Andrew Shenker; Allen Spiegel; Paolo Bianco; Pamela Robey
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.
The American journal of pathology 1997;151(6):1587-600.
1997: Larisa V Debelenko; E Brambilla; Sunita K Agarwal; Jennifer I Swalwell; MB Kester; Irina A Lubensky; Zhengping Zhuang; Siradanahalli Guru; P Manickam; SE Olufemi; Settara C Chandrasekharappa; Judy S Crabtree; Yong-Suk Kim; C Heppner; A Lee Burns; Allen Spiegel; Stephen J Marx; Lance A Liotta; Francis S Collins; William D Travis; Michael R Emmert-Buck
Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung.
Human molecular genetics 1997;6(13):2285-90.
1997: P Manickam; Siradanahalli Guru; Larisa V Debelenko; Sunita K Agarwal; SE Olufemi; JM Weisemann; Mark S Boguski; Judy S Crabtree; Y Wang; BA Roe; Irina A Lubensky; Zhengping Zhuang; MB Kester; A Lee Burns; Allen Spiegel; Stephen J Marx; Lance A Liotta; Michael R Emmert-Buck; Francis S Collins; Settara C Chandrasekharappa
Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region.
Human genetics 1997;101(1):102-8.
1997: Paul K Goldsmith; G Fan; J L Miller; KV Rogers; Allen Spiegel
Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1997;12(11):1780-8.
1997: Zhengping Zhuang; Alexander O Vortmeyer; Svetlana Pack; S Huang; T A Pham; Chaoyu Wang; WS Park; Sunita K Agarwal; Larisa V Debelenko; M Kester; Siradanahalli Guru; P Manickam; SE Olufemi; F Yu; C Heppner; Judy S Crabtree; Monica C Skarulis; David J Venzon; Michael R Emmert-Buck; Allen Spiegel; Settara C Chandrasekharappa; Francis S Collins; A Lee Burns; Stephen J Marx; Irina A Lubensky
Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.
Cancer research 1997;57(21):4682-6.
1997: M S Rodriguez-Pena; R Collins; C Woodard; Allen Spiegel
Decreased insulin content and secretion in RIN 1046-38 cells overexpressing alpha 2-adrenergic receptors.
Endocrine 1997;7(2):255-60.
1997: Allen Spiegel
Citation for the 1997 Gerald D. Aurbach Lecture Award of The Endocrine Society to Edward M. Brown.
Endocrine reviews 1997;18(4):616-7.
1997: Francesco De Luca; K Ray; EE Mancilla; GF Fan; Karen K Winer; P Gore; Allen Spiegel; Jeffrey Baron
Sporadic hypoparathyroidism caused by de Novo gain-of-function mutations of the Ca(2+)-sensing receptor.
The Journal of clinical endocrinology and metabolism 1997;82(8):2710-5.
1997: C Heppner; MB Kester; Sunita K Agarwal; Larisa V Debelenko; Michael R Emmert-Buck; Siradanahalli Guru; P Manickam; SE Olufemi; Monica C Skarulis; John L Doppman; H Richard Alexander; Yong-Suk Kim; SK Saggar; Irina A Lubensky; Zhengping Zhuang; Lance A Liotta; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; A Lee Burns; Stephen J Marx
Somatic mutation of the MEN1 gene in parathyroid tumours.
Nature genetics 1997;16(4):375-8.
1997: Siradanahalli Guru; Sunita K Agarwal; P Manickam; SE Olufemi; Judy S Crabtree; JM Weisemann; MB Kester; Yong-Suk Kim; Y Wang; Michael R Emmert-Buck; Lance A Liotta; Allen Spiegel; Mark S Boguski; BA Roe; Francis S Collins; Stephen J Marx; L Burns; Settara C Chandrasekharappa
A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.
Genome research 1997;7(7):725-35.
1997: Thomas Darling; Monica C Skarulis; Seth M Steinberg; Stephen J Marx; Allen Spiegel; M Turner
Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.
Archives of dermatology 1997;133(7):853-7.
1997: Sunita K Agarwal; MB Kester; Larisa V Debelenko; C Heppner; Michael R Emmert-Buck; Monica C Skarulis; John L Doppman; Yong-Suk Kim; Irina A Lubensky; Zhengping Zhuang; J S Green; Siradanahalli Guru; P Manickam; SE Olufemi; Lance A Liotta; Settara C Chandrasekharappa; Francis S Collins; Allen Spiegel; A Lee Burns; Stephen J Marx
Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.
Human molecular genetics 1997;6(7):1169-75.
1997: Siradanahalli Guru; SE Olufemi; P Manickam; C Cummings; L M Gieser; BL Pike; Michael Bittner; Y Jiang; A C Chinault; N J Nowak; A Brzozowska; Judy S Crabtree; Y Wang; BA Roe; JM Weisemann; Mark S Boguski; Sunita K Agarwal; A Lee Burns; Allen Spiegel; Stephen J Marx; W L Flejter; P J de Jong; Francis S Collins; Settara C Chandrasekharappa
A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13.
Genomics 1997;42(3):436-45.
1997: Allen Spiegel
Inborn errors of signal transduction: mutations in G proteins and G protein-coupled receptors as a cause of disease.
Journal of inherited metabolic disease 1997;20(2):113-21.
1997: Larisa V Debelenko; Zhengping Zhuang; Michael R Emmert-Buck; Settara C Chandrasekharappa; P Manickam; Siradanahalli Guru; Stephen J Marx; Monica C Skarulis; Allen Spiegel; Francis S Collins; Robert T Jensen; Lance A Liotta; Irina A Lubensky
Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.
Cancer research 1997;57(11):2238-43.
1997: Michael R Emmert-Buck; Irina A Lubensky; Qiong Dong; P Manickam; Siradanahalli Guru; MB Kester; SE Olufemi; S Agarwal; A Lee Burns; Allen Spiegel; Francis S Collins; Stephen J Marx; Zhengping Zhuang; Lance A Liotta; Settara C Chandrasekharappa; Larisa V Debelenko
Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis.
Cancer research 1997;57(10):1855-8.
1997: Q Dong; Larisa V Debelenko; Settara C Chandrasekharappa; Michael R Emmert-Buck; Zhengping Zhuang; Siradanahalli Guru; P Manickam; Monica C Skarulis; Irina A Lubensky; Lance A Liotta; Francis S Collins; Stephen J Marx; Allen Spiegel
Loss of heterozygosity at 11q13: analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1.
The Journal of clinical endocrinology and metabolism 1997;82(5):1416-20.
1997: G Fan; Paul K Goldsmith; R Collins; C K Dunn; K J Krapcho; KV Rogers; Allen Spiegel
N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface.
Endocrinology 1997;138(5):1916-22.
1997: Settara C Chandrasekharappa; Siradanahalli Guru; P Manickam; SE Olufemi; Francis S Collins; Michael R Emmert-Buck; Larisa V Debelenko; Zhengping Zhuang; Irina A Lubensky; Lance A Liotta; Judy S Crabtree; Y Wang; BA Roe; JM Weisemann; Mark S Boguski; Sunita K Agarwal; MB Kester; Yong-Suk Kim; C Heppner; Qiong Dong; Allen Spiegel; A Lee Burns; Stephen J Marx
Positional cloning of the gene for multiple endocrine neoplasia-type 1.
Science (New York, N.Y.) 1997;276(5311):404-7.
1997: Larisa V Debelenko; Michael R Emmert-Buck; P Manickam; M Kester; Siradanahalli Guru; E M DiFranco; SE Olufemi; S Agarwal; Irina A Lubensky; Zhengping Zhuang; A Lee Burns; Allen Spiegel; Lance A Liotta; Francis S Collins; Stephen J Marx; Settara C Chandrasekharappa
Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene.
Cancer research 1997;57(6):1039-42.
1997: Allen Spiegel
The molecular basis of disorders caused by defects in G proteins.
Hormone research 1997;47(3):89-96.
1996: D Wenkert; Torsten Schöneberg; J J Merendino; M S Rodriguez Pena; R Vinitsky; Paul K Goldsmith; Jürgen Wess; Allen Spiegel
Functional characterization of five V2 vasopressin receptor gene mutations.
Molecular and cellular endocrinology 1996;124(1-2):43-50.
1996: Irina A Lubensky; Larisa V Debelenko; Zhengping Zhuang; Michael R Emmert-Buck; Qiong Dong; Settara C Chandrasekharappa; Siradanahalli Guru; P Manickam; SE Olufemi; Stephen J Marx; Allen Spiegel; Francis S Collins; Lance A Liotta
Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.
Cancer research 1996;56(22):5272-8.
1996: John L Doppman; Monica C Skarulis; Clara C Chen; R Chang; Harvey I Pass; Douglas L Fraker; H Richard Alexander; B Niederle; S J Marx; Jeffrey A Norton; S A Wells; Allen Spiegel
Parathyroid adenomas in the aortopulmonary window.
Radiology 1996;201(2):456-62.
1996: N Jaskowiak; Jeffrey A Norton; H Richard Alexander; John L Doppman; Thomas Shawker; Monica C Skarulis; S Marx; Allen Spiegel; Douglas L Fraker
A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma.
Annals of surgery 1996;224(3):308-20; discussion 320-1.
1996: Allen Spiegel
Mutations in G proteins and G protein-coupled receptors in endocrine disease.
The Journal of clinical endocrinology and metabolism 1996;81(7):2434-42.
1996: Qiong Dong; Françoise Brucker-Davis; Bruce D Weintraub; R C Smallridge; F E Carr; J Battey; Allen Spiegel; A Shenker
Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes.
The Journal of clinical endocrinology and metabolism 1996;81(3):1134-40.
1996: S Hermouet; S Aznavoorian; Allen Spiegel
In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein.
Cellular signalling 1996;8(3):159-66.
1996: Allen Spiegel
Defects in G protein-coupled signal transduction in human disease.
Annual review of physiology 1996;58():143-70.
1995: Qiong Dong; A Shenker; J Way; B R Haddad; K Lin; M R Hughes; O W McBride; Allen Spiegel; J Battey
Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.
Genomics 1995;30(3):470-75.
1995: Clara C Chen; Monica C Skarulis; Douglas L Fraker; H Richard Alexander; S J Marx; Allen Spiegel
Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1995;36(12):2186-91.
1995: J F Buell; Douglas L Fraker; John L Doppman; Thomas Shawker; Monica C Skarulis; Allen Spiegel; Stephen J Marx; H Richard Alexander
High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism.
The American surgeon 1995;61(11):943-6.
1995: A Varrault; M S Pena; Paul K Goldsmith; A Mithal; E M Brown; Allen Spiegel
Expression of G protein alpha-subunits in bovine parathyroid.
Endocrinology 1995;136(10):4390-6.
1995: A Shenker; P Chanson; Lee S Weinstein; P Chi; Allen Spiegel; A Lomri; P J Marie
Osteoblastic cells derived from isolated lesions of fibrous dysplasia contain activating somatic mutations of the Gs alpha gene.
Human molecular genetics 1995;4(9):1675-6.
1995: Allen Spiegel
G protein gene knockout hits the gut.
Nature medicine 1995;1(6):522-4.
1995: Clara C Chen; Ahalya Premkumar; S C Hill; Monica C Skarulis; Allen Spiegel
Tc-99m sestamibi imaging of a hyperfunctioning parathyroid autograft with Doppler ultrasound and MRI correlation.
Clinical nuclear medicine 1995;20(3):222-5.
1994: MY Degtyarev; Allen Spiegel; Teresa L Z Jones
Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.
The Journal of biological chemistry 1994;269(49):30898-903.
1994: Abdul B Abou-Samra; P K Goldsmith; L Y Xie; Harald Jüppner; Allen Spiegel; Gino V Segre
Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone.
Endocrinology 1994;135(6):2588-94.
1994: Kevin G Billingsley; Douglas L Fraker; John L Doppman; Jeffrey A Norton; Thomas Shawker; Monica C Skarulis; Stephen J Marx; Allen Spiegel; H Richard Alexander
Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism.
Surgery 1994;116(6):982-9; discussion 989-90.
1994: M P MacFarlane; Douglas L Fraker; Thomas Shawker; Jeffrey A Norton; John L Doppman; R A Chang; Monica C Skarulis; Stephen J Marx; Allen Spiegel; H Richard Alexander
Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism.
Surgery 1994;116(6):959-64; discussion 964-5.
1994: John L Doppman; Thomas Shawker; Douglas L Fraker; H Richard Alexander; Monica C Skarulis; E E Lack; Allen Spiegel
Parathyroid adenoma within the vagus nerve.
AJR. American journal of roentgenology 1994;163(4):943-5.
1994: A Shenker; Lee S Weinstein; D E Sweet; Allen Spiegel
An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome.
The Journal of clinical endocrinology and metabolism 1994;79(3):750-5.
1994: D Wenkert; J J Merendino; A Shenker; N Thambi; Gray L Robertson; A M Moses; Allen Spiegel
Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus.
Human molecular genetics 1994;3(8):1429-30.
1994: V J LaMorte; J Thorburn; D Absher; Allen Spiegel; Joan Heller Brown; K R Chien; James R Feramisco; K U Knowlton
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
The Journal of biological chemistry 1994;269(18):13490-6.
1994: MY Degtyarev; Allen Spiegel; Teresa L Z Jones
The membrane localization of the G protein alpha s subunit is not dependent on its TENIR sequence or effector domain.
Cellular signalling 1994;6(1):25-33.
1993: S L Sugg; Douglas L Fraker; H Richard Alexander; John L Doppman; D L Miller; R Chang; Monica C Skarulis; Stephen J Marx; Allen Spiegel; Jeffrey A Norton
Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism.
Surgery 1993;114(6):1004-9; discussion 1009-10.
1993: MY Degtyarev; Allen Spiegel; Teresa L Z Jones
Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.
The Journal of biological chemistry 1993;268(32):23769-72.
1993: Henrik G Dohlman; P Goldsmith; Allen Spiegel; Jeremy Thorner
Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(20):9688-92.
1993: A Shenker; Lee S Weinstein; A Moran; Ora Hirsch Pescovitz; N J Charest; C M Boney; Judson Vanwyk; M J Merino; Penelope Feuillan; Allen Spiegel
Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.
The Journal of pediatrics 1993;123(4):509-18.
1993: Allen Spiegel; Lee S Weinstein; A Shenker
Abnormalities in G protein-coupled signal transduction pathways in human disease.
The Journal of clinical investigation 1993;92(3):1119-25.
1993: MY Degtyarev; Allen Spiegel; Teresa L Z Jones
The G protein alpha s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification.
Biochemistry 1993;32(32):8057-61.
1993: S Hermouet; T Murakami; Allen Spiegel
Stable changes in expression or activation of G protein alpha i or alpha q subunits affect the expression of both beta 1 and beta 2 subunits.
FEBS letters 1993;327(2):183-8.
1993: R Pamukcu; Allen Spiegel; Eugene B Chang
Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte.
The Journal of laboratory and clinical medicine 1993;121(5):689-96.
1993: V J LaMorte; A T Harootunian; Allen Spiegel; Roger Y Tsien; James R Feramisco
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2.
The Journal of cell biology 1993;121(1):91-9.
1993: S Hermouet; Philippe de Mazancourt; Allen Spiegel
Mitogenic effects of pertussis toxin-sensitive G-protein alpha subunits: the mitogenic action of alpha i2 in NIH 3T3 cells is mimicked by alpha i1, but not alpha i3.
Cellular signalling 1993;5(2):215-25.
1993: T L Jones; C Woodard; Allen Spiegel
Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit.
Protein expression and purification 1993;4(1):64-71.
1993: Allen Spiegel; Lee S Weinstein; A Shenker; S Hermouet; J J Merendino
G proteins: from basic to clinical studies.
Advances in second messenger and phosphoprotein research 1993;28():37-46.
1992: Eitan Friedman; L De Marco; Pablo V Gejman; Jeffrey A Norton; Allen E Bale; G D Aurbach; Allen Spiegel; Stephen J Marx
Allelic loss from chromosome 11 in parathyroid tumors.
Cancer research 1992;52(24):6804-9.
1992: S Hermouet; Philippe de Mazancourt; Allen Spiegel; M G Farquhar; B S Wilson
High level expression of transfected G protein alpha i3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts.
FEBS letters 1992;312(2-3):223-8.
1992: J T Potts; Allen Spiegel
In memoriam Gerald D. Aurbach.
Molecular endocrinology (Baltimore, Md.) 1992;6(11):1982-4.
1992: J T Potts; Allen Spiegel
In memoriam Gerald D. Aurbach.
The Journal of clinical endocrinology and metabolism 1992;75(5):1386-8.
1992: Y S Juhnn; T L Jones; Allen Spiegel
Amino- and carboxy-terminal deletion mutants of Gs alpha are localized to the particulate fraction of transfected COS cells.
The Journal of cell biology 1992;119(3):523-30.
1992: J E Butrynski; Teresa L Z Jones; P S Backlund; Allen Spiegel
Differential isoprenylation of carboxy-terminal mutants of an inhibitory G-protein alpha-subunit: neither farnesylation nor geranylgeranylation is sufficient for membrane attachment.
Biochemistry 1992;31(34):8030-5.
1992: Carlo Chiavaroli; D M Cooper; C L Boyajian; R Murray-Whelan; N Demaurex; Allen Spiegel; Werner Schlegel
Spontaneous Intracellular Calcium Oscillations and G(s) α Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells.
Journal of neuroendocrinology 1992;4(4):473-81.
1992: Lee S Weinstein; Pablo V Gejman; Philippe de Mazancourt; N American; Allen Spiegel
A heterozygous 4-bp deletion mutation in the Gs alpha gene (GNAS1) in a patient with Albright hereditary osteodystrophy.
Genomics 1992;13(4):1319-21.
1992: Allen Spiegel; A Shenker; Lee S Weinstein
Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.
Endocrine reviews 1992;13(3):536-65.
1992: Judy L Meinkoth; P K Goldsmith; Allen Spiegel; James R Feramisco; G N Burrow
Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, Gs.
The Journal of biological chemistry 1992;267(19):13239-45.
1992: Allen Spiegel
G proteins in cellular control.
Current opinion in cell biology 1992;4(2):203-11.
1992: T Murakami; William F Simonds; Allen Spiegel
Site-specific antibodies directed against G protein beta and gamma subunits: effects on alpha and beta gamma subunit interaction.
Biochemistry 1992;31(11):2905-11.
1992: Gerard M Doherty; John L Doppman; D L Miller; M S Gee; Stephen J Marx; Allen Spiegel; G D Aurbach; Harvey I Pass; Murray F Brennan; Jeffrey A Norton
Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism.
Annals of surgery 1992;215(2):101-6.
1992: V J LaMorte; P K Goldsmith; Allen Spiegel; Judy L Meinkoth; James R Feramisco
Inhibition of DNA synthesis in living cells by microinjection of Gi2 antibodies.
The Journal of biological chemistry 1992;267(2):691-4.
1992: Allen Spiegel
Heterotrimeric GTP-binding proteins: an expanding family of signal transducers.
Medicinal research reviews 1992;12(1):55-71.
1992: Allen Spiegel
Role of G proteins in signal transduction.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():200A-201A.
1991: Lee S Weinstein; A Shenker; Pablo V Gejman; M J Merino; Eitan Friedman; Allen Spiegel
Activating mutations of the stimulatory G protein in the McCune-Albright syndrome.
The New England journal of medicine 1991;325(24):1688-95.
1991: Stephen J Marx; J Menczel; G Campbell; G D Aurbach; Allen Spiegel; Jeffrey A Norton
Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1.
Clinical endocrinology 1991;35(6):521-6.
1991: S Hermouet; J J Merendino; J Silvio Gutkind; Allen Spiegel
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10455-9.
1991: Susan Hamilton; J Codina; M J Hawkes; A Yatani; T Sawada; F M Strickland; Stanley Froehner; Allen Spiegel; Ligia Toro; Enrico Stefani
Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle.
The Journal of biological chemistry 1991;266(29):19528-35.
1991: Allen Spiegel
Pathophysiology of primary hyperparathyroidism.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1991;6 Suppl 2():S15-7; discussion S31-2.
1991: Allen Spiegel; P S Backlund; J E Butrynski; Teresa L Z Jones; William F Simonds
The G protein connection: molecular basis of membrane association.
Trends in biochemical sciences 1991;16(9):338-41.
1991: Mireille Cormont; Yannick Le Marchand-Brustel; Emmanuel Van Obberghen; Allen Spiegel; Geoffrey W G Sharp
Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor.
Diabetes 1991;40(9):1170-6.
1991: Martine Bégeot; Dominique Langlois; Allen Spiegel; José M Saez
Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-II.
Endocrinology 1991;128(6):3162-8.
1991: A Shenker; P Goldsmith; Cecilia G Unson; Allen Spiegel
The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.
The Journal of biological chemistry 1991;266(14):9309-13.
1991: W Holter; Allen Spiegel; B H Howard; S Weber; M R Brann
Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation.
Cellular immunology 1991;134(2):287-95.
1991: Pablo V Gejman; Lee S Weinstein; Maria Martinez; Allen Spiegel; Q Cao; W T Hsieh; Margret R Hoehe; Elliot S Gershon
Genetic mapping of the Gs-alpha subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis.
Genomics 1991;9(4):782-3.
1991: William F Simonds; J E Butrynski; N Gautam; Cecilia G Unson; Allen Spiegel
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
The Journal of biological chemistry 1991;266(9):5363-6.
1991: Douglas L Fraker; William D Travis; J J Merendino; M B Zimering; Elizabeth A Streeten; Lee S Weinstein; Stephen J Marx; Allen Spiegel; G D Aurbach; John L Doppman
Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism.
Annals of surgery 1991;213(1):58-65.
1991: A Shenker; P Goldsmith; Cecilia G Unson; Allen Spiegel
The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.
Transactions of the Association of American Physicians 1991;104():11-20.
1991: A Fargin; K Yamamoto; S Cotecchia; P K Goldsmith; Allen Spiegel; E G Lapetina; Marc G Caron; R J Lefkowitz
Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.
Cellular signalling 1991;3(6):547-57.
1990: Teresa L Z Jones; Allen Spiegel
Isoprenylation of an inhibitory G protein alpha subunit occurs only upon mutagenesis of the carboxyl terminus.
The Journal of biological chemistry 1990;265(32):19389-92.
1990: Lee S Weinstein; Pablo V Gejman; Eitan Friedman; T Kadowaki; R M Collins; E S Gershon; Allen Spiegel
Mutations of the Gs alpha-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8287-90.
1990: D Morris; E McHugh-Sutkowski; M Moos; W F Simonds; Allen Spiegel; K B Seamon
Immunoprecipitation of adenylate cyclase with an antibody to a carboxyl-terminal peptide from Gs alpha.
Biochemistry 1990;29(38):9079-84.
1990: P S Backlund; William F Simonds; Allen Spiegel
Carboxyl methylation and COOH-terminal processing of the brain G-protein gamma-subunit.
The Journal of biological chemistry 1990;265(26):15572-6.
1990: Eitan Friedman; Allen E Bale; Stephen J Marx; Jeffrey A Norton; A Arnold; T Tu; G D Aurbach; Allen Spiegel
Genetic abnormalities in sporadic parathyroid adenomas.
The Journal of clinical endocrinology and metabolism 1990;71(2):293-7.
1990: dermot cooper; C L Boyajian; Paul K Goldsmith; C G Unson; Allen Spiegel
Differential expression of low molecular weight form of Gs-alpha in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase.
Brain research 1990;523(1):143-6.
1990: Lee S Weinstein; I Kats; Allen Spiegel; A D Carter
Characterization of the promoter of the human Gi2 alpha-subunit gene.
Molecular endocrinology (Baltimore, Md.) 1990;4(7):958-64.
1990: Allen Spiegel
Albright's hereditary osteodystrophy and defective G proteins.
The New England journal of medicine 1990;322(20):1461-2.
1990: Douglas L Fraker; John L Doppman; Thomas Shawker; Stephen J Marx; Allen Spiegel; Jeffrey A Norton
Undescended parathyroid adenoma: an important etiology for failed operations for primary hyperparathyroidism.
World journal of surgery 1990;14(3):342-8.
1990: S E Senogles; Allen Spiegel; E Padrell; Ravi Iyengar; Marc G Caron
Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.
The Journal of biological chemistry 1990;265(8):4507-14.
1990: William J Wolfgang; F Quan; P Goldsmith; C Unson; Allen Spiegel; Michael Forte
Immunolocalization of G protein alpha-subunits in the Drosophila CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(3):1014-24.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment.
Biochemical Society symposium 1990;56():61-9.
1990: Allen Spiegel; William F Simonds; Teresa L Z Jones; Paul K Goldsmith; Cecilia G Unson
Antibodies against synthetic peptides as probes of G protein structure and function.
Society of General Physiologists series 1990;45():185-95.
1990: Teresa L Z Jones; William F Simonds; J J Merendino; Mark R Brann; Allen Spiegel
Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):568-72.
1990: Allen Spiegel
Receptor-effector coupling by G-proteins: implications for neuronal plasticity.
Progress in brain research 1990;86():269-76.
1989: T Murakami; K Rossiter; Allen Spiegel; B Sacktor
Identification of multiple Gi subtypes and a novel G protein in bovine kidney cortex.
Biochemical pharmacology 1989;38(24):4502-5.
1989: S Daniel-Issakani; Allen Spiegel; B Strulovici
Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937.
The Journal of biological chemistry 1989;264(34):20240-7.
1989: N C Thambi; F Quan; William J Wolfgang; Allen Spiegel; Michael Forte
Immunological and molecular characterization of Go alpha-like proteins in the Drosophila central nervous system.
The Journal of biological chemistry 1989;264(31):18552-60.
1989: Allen Spiegel
Receptor-effector coupling by G-proteins implications for endocrinology.
Trends in endocrinology and metabolism: TEM 1989;1(2):72-6.
1989: J P Longabaugh; J Didsbury; Allen Spiegel; Gary L Stiles
Modification of the rat adipocyte A1 adenosine receptor-adenylate cyclase system during chronic exposure to an A1 adenosine receptor agonist: alterations in the quantity of GS alpha and Gi alpha are not associated with changes in their mRNAs.
Molecular pharmacology 1989;36(5):681-8.
1989: B R Lester; J B McCarthy; Z Q Sun; R S Smith; L T Furcht; Allen Spiegel
G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.
Cancer research 1989;49(21):5940-8.
1989: William F Simonds; R M Collins; Allen Spiegel; Mark R Brann
Membrane attachment of recombinant G-protein alpha-subunits in excess of beta gamma subunits in a eukaryotic expression system.
Biochemical and biophysical research communications 1989;164(1):46-53.
1989: William F Simonds; Paul K Goldsmith; J Codina; Cecilia G Unson; Allen Spiegel
Gi2 mediates alpha 2-adrenergic inhibition of adenylyl cyclase in platelet membranes: in situ identification with G alpha C-terminal antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(20):7809-13.
1989: William F Simonds; Paul K Goldsmith; C J Woodard; Cecilia G Unson; Allen Spiegel
Receptor and effector interactions of Gs. Functional studies with antibodies to the alpha s carboxyl-terminal decapeptide.
FEBS letters 1989;249(2):189-94.
1989: G G Holz; RM Kream; Allen Spiegel; Kathleen Dunlap
G proteins couple alpha-adrenergic and GABAb receptors to inhibition of peptide secretion from peripheral sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1989;9(2):657-66.
1989: R Sagi-Eisenberg; Linton Traub; Allen Spiegel; Yehiel Zick
Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins.
Cellular signalling 1989;1(5):519-31.
1988: R Cortés; Tomas Hökfelt; Martin Schalling; M Goldstein; P Goldsmith; Allen Spiegel; Cecilia G Unson; J Walsh
Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(23):9351-5.
1988: G E Darling; Stephen J Marx; Allen Spiegel; G D Aurbach; Jeffrey A Norton
Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3',5'-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism.
Surgery 1988;104(6):1128-36.
1988: P Goldsmith; P S Backlund; K Rossiter; A Carter; G Milligan; Cecilia G Unson; Allen Spiegel
Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go.
Biochemistry 1988;27(18):7085-90.
1988: Graeme Milligan; Ian Mullaney; Cecilia G Unson; L Marshall; Allen Spiegel; H McArdle
GTP analogues promote release of the alpha subunit of the guanine nucleotide binding protein, Gi2, from membranes of rat glioma C6 BU1 cells.
The Biochemical journal 1988;254(2):391-6.
1988: Daniel Rotrosen; John Gallin; Allen Spiegel; Harry L Malech
Subcellular localization of Gi alpha in human neutrophils.
The Journal of biological chemistry 1988;263(22):10958-64.
1988: F R McKenzie; Ian Mullaney; Cecilia G Unson; Allen Spiegel; Graeme Milligan
The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins.
Biochemical Society transactions 1988;16(4):434-7.
1988: Richard A Cerione; S Kroll; R Rajaram; Cecilia G Unson; P Goldsmith; Allen Spiegel
An antibody directed against the carboxyl-terminal decapeptide of the alpha subunit of the retinal GTP-binding protein, transducin. Effects on transducin function.
The Journal of biological chemistry 1988;263(19):9345-52.
1988: Allen Spiegel
G proteins in clinical medicine.
Hospital practice (Office ed.) 1988;23(6):93-100, 105-6, 111-2.
1988: Lee S Weinstein; Allen Spiegel; A D Carter
Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein.
FEBS letters 1988;232(2):333-40.
1988: P Goldsmith; K Rossiter; A Carter; William F Simonds; Cecilia G Unson; R Vinitsky; Allen Spiegel
Identification of the GTP-binding protein encoded by Gi3 complementary DNA.
The Journal of biological chemistry 1988;263(14):6476-9.
1988: P S Backlund; R R Aksamit; Cecilia G Unson; P Goldsmith; Allen Spiegel; G Milligan
Immunochemical and electrophoretic characterization of the major pertussis toxin substrate of the RAW264 macrophage cell line.
Biochemistry 1988;27(6):2040-6.
1988: R Collu; C Bouvier; G Lagacé; Cecilia G Unson; G Milligan; P Goldsmith; Allen Spiegel
Selective deficiency of guanine nucleotide-binding protein Go in two dopamine-resistant pituitary tumors.
Endocrinology 1988;122(3):1176-8.
1988: T Zaremba; P Gierschik; M Pines; P Bray; A Carter; R Kahn; C Simons; R Vinitsky; P Goldsmith; Allen Spiegel
Immunochemical studies of the 36-kDa common beta subunit of guanine nucleotide-binding proteins: identification of a major epitope.
Molecular pharmacology 1988;33(3):257-64.
1988: F R McKenzie; E C Kelly; Cecilia G Unson; Allen Spiegel; Graeme Milligan
Antibodies which recognize the C-terminus of the inhibitory guanine-nucleotide-binding protein (Gi) demonstrate that opioid peptides and foetal-calf serum stimulate the high-affinity GTPase activity of two separate pertussis-toxin substrates.
The Biochemical journal 1988;249(3):653-9.
1988: Allen Spiegel; A Carter; M Brann; R Collins; P Goldsmith; William F Simonds; R Vinitsky; B Eide; K Rossiter; L Weinstein
Signal transduction by guanine nucleotide-binding proteins.
Recent progress in hormone research 1988;44():337-75.
1988: Allen Spiegel
Guanine nucleotide binding proteins and signal transduction.
Vitamins and hormones 1988;44():47-101.
1987: D L Miller; John L Doppman; R Chang; J T Simmons; timothy o'leary; Jeffrey A Norton; Allen Spiegel; Stephen J Marx; G D Aurbach
Angiographic ablation of parathyroid adenomas: lessons from a 10-year experience.
Radiology 1987;165(3):601-7.
1987: B Eide; P Gierschik; G Milligan; Ian Mullaney; Cecilia G Unson; P Goldsmith; Allen Spiegel
GTP-binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini.
Biochemical and biophysical research communications 1987;148(3):1398-405.
1987: P Goldsmith; P Gierschik; G Milligan; Cecilia G Unson; R Vinitsky; H L Malech; Allen Spiegel
Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.
The Journal of biological chemistry 1987;262(30):14683-8.
1987: R P Lad; C Simons; P Gierschik; G Milligan; C Woodard; M Griffo; P Goldsmith; R Ornberg; Charles R Gerfen; Allen Spiegel
Differential distribution of signal-transducing G-proteins in retina.
Brain research 1987;423(1-2):237-46.
1987: K A Kern; T H Shawker; J L Doppman; D L Miller; S J Marx; Allen Spiegel; G D Aurbach; J A Norton
The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism.
World journal of surgery 1987;11(5):579-85.
1987: Graeme Milligan; Allen Spiegel; Cecilia G Unson; E D Saggerson
Chemically induced hypothyroidism produces elevated amounts of the alpha subunit of the inhibitory guanine nucleotide binding protein (Gi) and the beta subunit common to all G-proteins.
The Biochemical journal 1987;247(1):223-7.
1987: A Carter; C Bardin; R Collins; C Simons; P Bray; Allen Spiegel
Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7266-9.
1987: Mark R Brann; R M Collins; Allen Spiegel
Localization of mRNAs encoding the alpha-subunits of signal-transducing G-proteins within rat brain and among peripheral tissues.
FEBS letters 1987;222(1):191-8.
1987: P M Murphy; B Eide; P Goldsmith; M Brann; P Gierschik; Allen Spiegel; H L Malech
Detection of multiple forms of Gi alpha in HL60 cells.
FEBS letters 1987;221(1):81-6.
1987: P Bray; A Carter; V Guo; C Puckett; John Kamholz; Allen Spiegel; Marshall Nirenberg
Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5115-9.
1987: Charles W Luetje; P Gierschik; G Milligan; C Unson; Allen Spiegel; Neil M Nathanson
Tissue-specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development.
Biochemistry 1987;26(15):4876-84.
1987: Yehiel Zick; Allen Spiegel; R Sagi-Eisenberg
Insulin-like growth factor I receptors in retinal rod outer segments.
The Journal of biological chemistry 1987;262(21):10259-64.
1987: G Milligan; R A Streaty; P Gierschik; Allen Spiegel; W A Klee
Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain.
The Journal of biological chemistry 1987;262(18):8626-30.
1987: D Gawler; G Milligan; Allen Spiegel; C G Unson; Miles D Houslay
Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes.
Nature 1987;327(6119):229-32.
1987: P Gierschik; D Sidiropoulos; Allen Spiegel; K H Jakobs
Purification and immunochemical characterization of the major pertussis-toxin-sensitive guanine-nucleotide-binding protein of bovine-neutrophil membranes.
European journal of biochemistry / FEBS 1987;165(1):185-94.
1987: S E Senogles; J L Benovic; N Amlaiky; Cecilia G Unson; G Milligan; R Vinitsky; Allen Spiegel; Marc G Caron
The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.
The Journal of biological chemistry 1987;262(10):4860-7.
1987: R A Cerione; P Gierschik; C Staniszewski; J L Benovic; J Codina; R Somers; Lutz Birnbaumer; Allen Spiegel; R J Lefkowitz; Marc G Caron
Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.
Biochemistry 1987;26(5):1485-91.
1987: G Milligan; P Gierschik; Allen Spiegel
The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins.
Biochemical Society transactions 1987;15(1):42-5.
1987: D L Miller; J L Doppman; A G Krudy; T H Shawker; J A Norton; J J Vucich; K A Morrish; S J Marx; Allen Spiegel; G D Aurbach
Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures.
Radiology 1987;162(1 Pt 1):138-41.
1987: D L Miller; J L Doppman; T H Shawker; A G Krudy; J A Norton; J J Vucich; K A Morrish; S J Marx; Allen Spiegel; G D Aurbach
Localization of parathyroid adenomas in patients who have undergone surgery. Part I. Noninvasive imaging methods.
Radiology 1987;162(1 Pt 1):133-7.
1987: Allen Spiegel
Signal transduction by guanine nucleotide binding proteins.
Molecular and cellular endocrinology 1987;49(1):1-16.
1986: J Falloon; H Malech; G Milligan; Cecilia G Unson; R Kahn; P Goldsmith; Allen Spiegel
Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides.
FEBS letters 1986;209(2):352-6.
1986: Yehiel Zick; R Sagi-Eisenberg; M Pines; P Gierschik; Allen Spiegel
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(24):9294-7.
1986: P Bray; A Carter; C Simons; V Guo; C Puckett; John Kamholz; Allen Spiegel; Marshall Nirenberg
Human cDNA clones for four species of G alpha s signal transduction protein.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(23):8893-7.
1986: B Eide; P Gierschik; Allen Spiegel
Immunochemical detection of guanine nucleotide binding proteins mono-ADP-ribosylated by bacterial toxins.
Biochemistry 1986;25(21):6711-5.
1986: M Pines; A Santora; Allen Spiegel
Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells.
Biochemical pharmacology 1986;35(20):3639-41.
1986: R S Weinstock; H N Wright; Allen Spiegel; Michael A. Levine; A M Moses
Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein.
Nature 1986;322(6080):635-6.
1986: J A Norton; T H Shawker; B L Jones; Allen Spiegel; S J Marx; L Fitzpatrick; G D Aurbach; J L Doppman
Intraoperative ultrasound and reoperative parathyroid surgery: an initial evaluation.
World journal of surgery 1986;10(4):631-9.
1986: R A Cerione; C Staniszewski; P Gierschik; J Codina; R L Somers; Lutz Birnbaumer; Allen Spiegel; Marc G Caron; R J Lefkowitz
Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.
The Journal of biological chemistry 1986;261(20):9514-20.
1986: P Gierschik; J Falloon; G Milligan; M Pines; John Gallin; Allen Spiegel
Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils.
The Journal of biological chemistry 1986;261(17):8058-62.
1986: M L Brandi; G D Aurbach; L A Fitzpatrick; R Quarto; Allen Spiegel; Michael M Bliziotes; J A Norton; J L Doppman; S J Marx
Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1.
The New England journal of medicine 1986;314(20):1287-93.
1986: P Gierschik; Bernice E Morrow; G Milligan; Charles S Rubin; Allen Spiegel
Changes in the guanine nucleotide-binding proteins, Gi and Go, during differentiation of 3T3-L1 cells.
FEBS letters 1986;199(1):103-6.
1986: P Gierschik; G Milligan; M Pines; P Goldsmith; J Codina; W Klee; Allen Spiegel
Use of specific antibodies to quantitate the guanine nucleotide-binding protein Go in brain.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(7):2258-62.
1986: C Silve; A Santora; Neil A Breslau; A Moses; Allen Spiegel
Selective resistance to parathyroid hormone in cultured skin fibroblasts from patients with pseudohypoparathyroidism type Ib.
The Journal of clinical endocrinology and metabolism 1986;62(4):640-4.
1986: R A Cerione; John W Regan; H Nakata; J Codina; J L Benovic; P Gierschik; R L Somers; Allen Spiegel; Lutz Birnbaumer; R J Lefkowitz
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.
The Journal of biological chemistry 1986;261(8):3901-9.
1986: Michael A. Levine; T S Jap; R S Mauseth; Robert Downs; Allen Spiegel
Activity of the stimulatory guanine nucleotide-binding protein is reduced in erythrocytes from patients with pseudohypoparathyroidism and pseudopseudohypoparathyroidism: biochemical, endocrine, and genetic analysis of Albright's hereditary osteodystrophy in six kindreds.
The Journal of clinical endocrinology and metabolism 1986;62(3):497-502.
1986: G B Grunwald; P Gierschik; Marshall Nirenberg; Allen Spiegel
Detection of alpha-transducin in retinal rods but not cones.
Science (New York, N.Y.) 1986;231(4740):856-9.
1986: T van Veen; T Ostholm; P Gierschik; Allen Spiegel; R Somers; H W Korf; David Klein
alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(4):912-6.
1986: M Pines; A Santora; P Gierschik; J Menczel; Allen Spiegel
The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells.
Bone and mineral 1986;1(1):15-26.
1986: G Milligan; P Gierschik; Allen Spiegel; W A Klee
The GTP-binding regulatory proteins of neuroblastoma x glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No.
FEBS letters 1986;195(1-2):225-30.
1986: W E Heydorn; P Gierschik; G J Creed; G Milligan; Allen Spiegel; D M Jacobowitz
The beta subunit of the guanine nucleotide regulatory proteins: identification of its location on two-dimensional gels of brain tissue and its regional and subcellular distribution in brain.
Journal of neuroscience research 1986;16(3):541-52.
1985: J M Skibber; J C Reynolds; Allen Spiegel; S J Marx; L A Fitzpatrick; G D Aurbach; R A Wesley; J A Norton
Computerized technetium/thallium scans and parathyroid reoperation.
Surgery 1985;98(6):1077-82.
1985: A W Saxe; A Santora; J Norton; Timothy Triche; Murray F Brennan; Allen Spiegel
Morphologic and functional studies of a rat hypercalcemia-associated testicular tumor maintained in cell culture.
Surgery 1985;98(6):1013-23.
1985: P Gierschik; Allen Spiegel
Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase.
Archives of biochemistry and biophysics 1985;242(2):457-63.
1985: J L Doppman; T H Shawker; A G Krudy; D L Miller; S J Marx; Allen Spiegel; J A Norton; Murray F Brennan; M Schaaf; G D Aurbach
Parathymic parathyroid: CT, US, and angiographic findings.
Radiology 1985;157(2):419-23.
1985: R A Cerione; J Codina; B F Kilpatrick; C Staniszewski; P Gierschik; R L Somers; Allen Spiegel; Lutz Birnbaumer; Marc G Caron; R J Lefkowitz
Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.
Biochemistry 1985;24(17):4499-503.
1985: Robert Downs; R D Sekura; Michael A. Levine; Allen Spiegel
The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism.
The Journal of clinical endocrinology and metabolism 1985;61(2):351-4.
1985: M Pines; P Gierschik; G Milligan; W Klee; Allen Spiegel
Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(12):4095-9.
1985: C Silve; A Santora; Allen Spiegel
A factor produced by cultured rat Leydig tumor (Rice 500) cells associated with humoral hypercalcemia stimulates adenosine 3',5'-monophosphate production via the parathyroid hormone receptor in human skin fibroblasts.
The Journal of clinical endocrinology and metabolism 1985;60(6):1144-7.
1985: M Pines; P Gierschik; Allen Spiegel
The tryptic and chymotryptic fragments of the beta-subunit of guanine nucleotide binding proteins in brain are identical to those of retinal transducin.
FEBS letters 1985;182(2):355-9.
1985: R A Cerione; C Staniszewski; J L Benovic; R J Lefkowitz; Marc G Caron; P Gierschik; R Somers; Allen Spiegel; J Codina; Lutz Birnbaumer
Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.
The Journal of biological chemistry 1985;260(3):1493-500.
1985: P Gierschik; J Codina; C Simons; Lutz Birnbaumer; Allen Spiegel
Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(3):727-31.
1985: Allen Spiegel; P Gierschik; Michael A. Levine; Robert Downs
Clinical implications of guanine nucleotide-binding proteins as receptor-effector couplers.
The New England journal of medicine 1985;312(1):26-33.
1985: D R Dufour; S J Marx; Allen Spiegel
Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia.
The American journal of surgical pathology 1985;9(1):43-51.
1984: Allen Spiegel; M V Rudorfer; S J Marx; M Linnoila
The effect of short term lithium administration on suppressibility of parathyroid hormone secretion by calcium in vivo.
The Journal of clinical endocrinology and metabolism 1984;59(2):354-7.
1984: P Gierschik; C Simons; C Woodard; R Somers; Allen Spiegel
Antibodies against a retinal guanine nucleotide-binding protein cross-react with a single plasma membrane protein in non-retinal tissues.
FEBS letters 1984;172(2):321-5.
1984: A G Krudy; J L Doppman; S J Marx; J A Norton; Allen Spiegel; A C Santora; G D Aurbach
Parathyroid aspiration directed by angiography: an alternative to venous sampling.
Radiology 1984;152(1):207-8.
1984: J A Heinsimer; A O Davies; Robert Downs; Michael A. Levine; Allen Spiegel; Marc K Drezner; A De Lean; K A Wreggett; Marc G Caron; R J Lefkowitz
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
The Journal of clinical investigation 1984;73(5):1335-43.
1984: A G Krudy; J L Doppman; D L Miller; J A Norton; S J Marx; Allen Spiegel; A C Santora; G D Aurbach; M Schaaf
Detection of mediastinal parathyroid glands by nonselective digital arteriography.
AJR. American journal of roentgenology 1984;142(4):693-5.
1984: A G Krudy; T H Shawker; J L Doppman; K Horvath; Philip D Schneider; J A Norton; S J Marx; Allen Spiegel
Ultrasonic parathyroid localisation in previously operated patients.
Clinical radiology 1984;35(2):113-8.
1984: C S Tam; J N Heersche; A Santora; Allen Spiegel
Skeletal response in rats following the implantation of hypercalcemia-producing Leydig cell tumors.
Metabolism: clinical and experimental 1984;33(1):50-3.
1984: A G Krudy; J L Doppman; T H Shawker; Allen Spiegel; S J Marx; J Norton; M Schaaf; M L Moss; M A Weiss; S H Schachner
Hyperfunctioning cystic parathyroid glands: CT and sonographic findings.
AJR. American journal of roentgenology 1984;142(1):175-8.
1983: Allen Spiegel; Robert Downs; A Santora; S J Marx; J Doppman; J Shull
Persistent hyperparathyroidism caused by incomplete parathyroid resection and a hyperfunctioning parathyroid autograft.
JAMA : the journal of the American Medical Association 1983;250(14):1896-8.
1983: M F Attie; J R Gill; J L Stock; Allen Spiegel; Robert Downs; Michael A. Levine; S J Marx
Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism.
The Journal of clinical investigation 1983;72(2):667-76.
1983: J L Doppman; A G Krudy; S J Marx; A Saxe; Philip D Schneider; J A Norton; Allen Spiegel; Robert Downs; M Schaaf; M E Brennan; A B Schneider; G D Aurbach
Aspiration of enlarged parathyroid glands for parathyroid hormone assay.
Radiology 1983;148(1):31-5.
1983: Michael A. Levine; C Eil; Robert Downs; Allen Spiegel
Deficient guanine nucleotide regulatory unit activity in cultured fibroblast membranes from patients with pseudohypoparathyroidism type I. a cause of impaired synthesis of 3',5'-cyclic AMP by intact and broken cells.
The Journal of clinical investigation 1983;72(1):316-24.
1983: A G Krudy; J L Doppman; D L Miller; S J Marx; J A Norton; A C Santora; R D Lasker; Robert Downs; Allen Spiegel; G D Aurbach
Work in progress: abnormal parathyroid glands. Comparison of nonselective arterial digital arteriography, selective parathyroid arteriography, and venous digital arteriography as methods of detection.
Radiology 1983;148(1):23-9.
1983: Allen Spiegel; A W Saxe; L J Deftos; Murray F Brennan
Humoral hypercalcemia caused by a rat Leydig-cell tumor is associated with suppressed parathyroid hormone secretion and increased urinary cAMP excretion.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1983;15(6):299-304.
1983: Michael A. Levine; Robert Downs; A M Moses; Neil A Breslau; S J Marx; R D Lasker; R E Rizzoli; G D Aurbach; Allen Spiegel
Resistance to multiple hormones in patients with pseudohypoparathyroidism. Association with deficient activity of guanine nucleotide regulatory protein.
The American journal of medicine 1983;74(4):545-56.
1983: Allen Spiegel; S J Marx
Parathyroid hormone and vitamin D receptors.
Clinics in endocrinology and metabolism 1983;12(1):221-41.
1983: Robert Downs; Michael A. Levine; Marc K Drezner; W M Burch; Allen Spiegel
Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.
The Journal of clinical investigation 1983;71(2):231-5.
1982: R D Lasker; Allen Spiegel
Endogenous substrates for cAMP-dependent phosphorylation in dispersed bovine parathyroid cells.
Endocrinology 1982;111(4):1412-4.
1982: Allen Spiegel; Michael A. Levine; S J Marx; G D Aurbach
Pseudohypoparathyroidism: the molecular basis for hormone resistance--a retrospective.
The New England journal of medicine 1982;307(11):679-81.
1982: S J Marx; Allen Spiegel; Michael A. Levine; R E Rizzoli; R D Lasker; A C Santora; Robert Downs; G D Aurbach
Familial hypocalciuric hypercalcemia: the relation to primary parathyroid hyperplasia.
The New England journal of medicine 1982;307(7):416-26.
1982: Allen Spiegel; Michael A. Levine; G D Aurbach; Robert Downs; S J Marx; R D Lasker; A M Moses; Neil A Breslau
Deficiency of hormone receptor-adenylate cyclase coupling protein: basis for hormone resistance in pseudohypoparathyroidism.
The American journal of physiology 1982;243(1):E37-42.
1982: A W Saxe; Allen Spiegel; S J Marx; Murray F Brennan
Deferred parathyroid autografts with cryopreserved tissue after reoperative parathyroid surgery.
Archives of surgery (Chicago, Ill. : 1960) 1982;117(5):538-43.
1982: A G Krudy; J L Doppman; S J Marx; Murray F Brennan; Allen Spiegel; G D Aurback
Radiographic findings in recurrent parathyroid carcinoma.
Radiology 1982;142(3):625-9.
1982: W Krawietz; Robert Downs; Allen Spiegel; G D Aurbach
Vanadate stimulates adenylate cyclase via the guanine nucleotide regulatory protein by a mechanism differing from that of fluoride.
Biochemical pharmacology 1982;31(5):843-8.
1982: S J Marx; M F Attie; Allen Spiegel; Michael A. Levine; R D Lasker; M Fox
An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds.
The New England journal of medicine 1982;306(5):257-64.
1982: Murray F Brennan; J L Doppman; A G Kurdy; S J Marx; Allen Spiegel; G D Aurbach
Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism.
Surgery 1982;91(1):6-11.
1982: Allen Spiegel; Michael A. Levine
Pseudohypoparathyroidism: deficiency of hormone receptor-adenylate cyclase coupling protein as a cause of hereditary hormone resistance.
Progress in clinical and biological research 1982;97():327-40.
1982: J L Stock; Bruce D Weintraub; S W Rosen; G D Aurbach; Allen Spiegel; S J Marx
Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1982;54(1):57-63.
1981: Murray F Brennan; S J Marx; J Doppman; J Costa; A Saxe; Allen Spiegel; A Krudy; G Aurbach
Results of reoperation for persistent and recurrent hyperparathyroidism.
Annals of surgery 1981;194(6):671-6.
1981: S J Marx; M F Attie; Michael A. Levine; Allen Spiegel; Robert Downs; R D Lasker
The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds.
Medicine 1981;60(6):397-412.
1981: A G Krudy; J L Doppman; Murray F Brennan; S J Marx; Allen Spiegel; J L Stock; G D Aurbach
The detection of mediastinal parathyroid glands by computed tomography, selective arteriography, and venous sampling: an analysis of 17 cases.
Radiology 1981;140(3):739-44.
1981: Allen Spiegel; S J Marx; Murray F Brennan; E M Brown; Robert Downs; D G Gardner; M F Attie; G D Aurbach
Parathyroid function after parathyroidectomy: evaluation by measurement of urinary cAMP.
Clinical endocrinology 1981;15(1):65-73.
1981: A G Krudy; J L Doppman; S J Marx; Allen Spiegel; G Aurbach; Murray F Brennan
Failure of ablation of a mediastinal parathyroid adenoma by repeated contrast staining.
Radiology 1981;140(1):63-5.
1981: Robert Downs; S A Reen; Michael A. Levine; G D Aurbach; Allen Spiegel
Cholera-toxin-dependent ADP-ribosylation of the adenylate cyclase regulatory protein in turkey erythrocyte membranes.
Archives of biochemistry and biophysics 1981;209(1):284-90.
1981: J L Stock; A G Krudy; J L Doppman; A E Jones; Murray F Brennan; M F Attie; Robert Downs; Michael A. Levine; S J Marx; Allen Spiegel; G D Aurbach
Parathyroid imaging after intraarterial injections of [75Se]selenomethionine.
The Journal of clinical endocrinology and metabolism 1981;52(5):835-9.
1981: S J Marx; M F Attie; J L Stock; Allen Spiegel; Michael A. Levine
Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1981;52(4):736-40.
1981: Allen Spiegel; Robert Downs; Michael A. Levine; M J Singer; W Krawietz; S J Marx; C J Woodard; S A Reen; G D Aurbach
The role of guanine nucleotides in regulation of adenylate cyclase activity.
Recent progress in hormone research 1981;37():635-65.
1981: Allen Spiegel; Robert Downs
Guanine nucleotides: key regulators of hormone receptor-adenylate cyclase interaction.
Endocrine reviews 1981;2(3):275-305.
1980: Allen Spiegel; S T Eastman; M F Attie; Robert Downs; Michael A. Levine; S J Marx; J L Stock; A W Saxe; Murray F Brennan; G D Aurbach
Intraoperative measurements of urinary cyclic AMP to guide surgery for primary hyperparathyroidism.
The New England journal of medicine 1980;303(25):1457-60.
1980: M F Attie; E M Brown; D G Gardner; Allen Spiegel; G D Aurbach
Characterization of the dopamine-responsive adenylate cyclase of bovine parathyroid cells and its relationship to parathyroid hormone secretion.
Endocrinology 1980;107(6):1776-81.
1980: T B Nielsen; Robert Downs; Allen Spiegel
Restoration of guanine nucleotide- and fluoride-stimulated activity to an adenylate cyclase-deficient cell line with affinity-purified guanine nucleotide regulatory protein.
The Biochemical journal 1980;190(2):439-43.
1980: Michael A. Levine; Robert Downs; M Singer; S J Marx; G D Aurbach; Allen Spiegel
Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism.
Biochemical and biophysical research communications 1980;94(4):1319-24.
1980: S J Marx; G D Aurbach; Allen Spiegel
Incidence of primary hyperparathyroidism.
The New England journal of medicine 1980;302(23):1313.
1980: S J Marx; J L Stock; M F Attie; Robert Downs; D G Gardner; E M Brown; Allen Spiegel; J L Doppman; Murray F Brennan
Familial hypocalciuric hypercalcemia: recognition among patients referred after unsuccessful parathyroid exploration.
Annals of internal medicine 1980;92(3):351-6.
1980: S J Marx; Allen Spiegel; M E Sharp; E M Brown; D G Gardner; Robert Downs; M F Attie; J L Stock
Adenosine 3',5'-monophosphate response to parathyroid hormone: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1980;50(3):546-8.
1980: Robert Downs; Allen Spiegel; M Singer; S Reen; G D Aurbach
Fluoride stimulation of adenylate cyclase is dependent on the guanine nucleotide regulatory protein.
The Journal of biological chemistry 1980;255(3):949-54.
1980: S J Marx; Allen Spiegel; E M Brown; Robert Downs; M F Attie; J L Stock; Michael A. Levine; G D Aurbach
Urinary cyclic 3',5'-adenosine monophosphate (cAMP): an index of the action of parathyroid hormone on the kidney.
Progress in biochemical pharmacology 1980;17():182-9.
1979: D M McCarthy; S R Peikin; R N Lopatin; B W Long; Allen Spiegel; S Marx; Murray F Brennan
Hyperparathyroidism--a reversible cause of cimetidine-resistant gastric hypersecretion.
British medical journal 1979;1(6180):1765-6.
1979: E M Brown; D G Gardner; Murray F Brennan; S J Marx; Allen Spiegel; M F Attie; Robert Downs; J L Doppman; C D Aurbach
Calcium-regulated parathyroid hormone release in primary hyperparathyroidism: studies in vitro with dispersed parathyroid cells.
The American journal of medicine 1979;66(6):923-31.
1979: J L Doppman; S Marx; Allen Spiegel; E Brown; R Downs; Murray F Brennan; G Aurbach
Differential diagnosis of brown tumor vs. cystic osteitis by arteriography and computed tomography.
Radiology 1979;131(2):339-40.
1979: E M Brown; A E Broadus; Murray F Brennan; D G Gardner; S J Marx; Allen Spiegel; Robert Downs; M Attie; G D Aurbach
Direct comparison in vivo and in vitro of suppressibility of parathyroid function by calcium in primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1979;48(4):604-10.
1979: E M Brown; Murray F Brennan; A E Broadus; S J Marx; D G Gardner; Allen Spiegel; Robert Downs; M F Attie; G D Aurbach
Human parathyroid autografts: comparison of function in vivo and in vitro.
The Journal of clinical endocrinology and metabolism 1979;48(4):648-54.
1979: J L Doppman; E M Brown; Murray F Brennan; Allen Spiegel; S J Marx; G D Aurbach
Angiographic ablation of parathyroid adenomas.
Radiology 1979;130(3):577-82.
1979: Murray F Brennan; E M Brown; Allen Spiegel; S J Marx; J L Doppman; D C Jones; G D Aurbach
Autotransplantation of cryopreserved parathyroid tissue in man.
Annals of surgery 1979;189(2):139-42.
1979: Allen Spiegel; Robert Downs; G D Aurbach
Separation of a guanine nucleotide regulatory unit from the adenylate cyclase complex with GTP affinity chromatography.
Journal of cyclic nucleotide research 1979;5(1):3-17.
1978: S J Marx; Allen Spiegel; E M Brown; D G Gardner; Robert Downs; M Attie; A J Hamstra; H F DeLuca
A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D.
The Journal of clinical endocrinology and metabolism 1978;47(6):1303-10.
1978: S J Marx; Allen Spiegel; E M Brown; R Windeck; D G Gardner; Robert Downs; M Attie; G D Aurbach
Circulating parathyroid hormone activity: familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1978;47(6):1190-7.
1978: Allen Spiegel; J L Doppman; S J Marx; Murray F Brennan; E M Brown; Robert Downs; D G Gardner; M Attie; G D Aurbach
Preoperative localization of abnormal parathyroid: neck massage versus arteriography and selective venous sampling.
Annals of internal medicine 1978;89(6):935-6.
1978: Murray F Brennan; E M Brown; S J Marx; Allen Spiegel; A E Broadus; J L Doppman; B Webber; G D Aurbach
Recurrent hyperparathyroidism from an autotransplanted parathyroid adenoma.
The New England journal of medicine 1978;299(19):1057-9.
1978: E Hewlett; Allen Spiegel; J Wolff; G Aurbach; C R Manclark
Bordetella pertussis does not induce beta-adrenergic blockade.
Infection and immunity 1978;22(2):430-4.
1978: Allen Spiegel; S J Marx; Murray F Brennan; E M Brown; J O Koehler; G D Aurbach
Urinary cAMP excretion during surgery: an index of successful parathyroidectomy in patients with primary hyperparathyroidism.
The Journal of clinical endocrinology and metabolism 1978;47(3):537-42.
1978: S J Marx; Allen Spiegel; E M Brown; J O Koehler; D G Gardner; Murray F Brennan; G D Aurbach
Divalent cation metabolism. Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism.
The American journal of medicine 1978;65(2):235-42.
1978: Murray F Brennan; J L Doppman; S J Marx; Allen Spiegel; E M Brown; G D Aurbach
Reoperative parathyroid surgery for persistent hyperparathyroidism.
Surgery 1978;83(6):669-76.
1978: Allen Spiegel; R Lopatin; S Peikin; D McCarthy
Serum-prolactin in patients receiving chronic oral cimetidine.
Lancet 1978;1(8069):881.
1978: Allen Spiegel; S W Rosen; Bruce D Weintraub; S P Marynick
Effect of intravenous pyridoxine on plasma prolactin in hyperprolactinemic subjects.
The Journal of clinical endocrinology and metabolism 1978;46(4):686-8.
1978: Allen Spiegel; M Greene; I Magrath; J Balow; S Marx; G D Aurbach
Hypercalcemia with suppressed parathyroid hormone in Burkitt's lymphoma.
The American journal of medicine 1978;64(4):691-5.
1978: E M Brown; Murray F Brennan; S Hurwitz; R Windeck; S J Marx; Allen Spiegel; J O Koehler; D G Gardner; G D Aurbach
Dispersed cells prepared from human parathyroid glands: distinct calcium sensitivity of adenomas vs. primary hyperplasia.
The Journal of clinical endocrinology and metabolism 1978;46(2):267-75.
1977: C R Kollarits; M L Moss; D G Cogan; J L Doppman; G Di Chiro; G B Cutler; S J Marx; Allen Spiegel
Scleral calcifications in hyperparathyroidism: demonstration by computed tomography.
Journal of computer assisted tomography 1977;1(4):500-4.
1977: J P Bilezikian; Allen Spiegel; D E Gammon; G D Aurbach
The role of guanyl nucleotides in the expression on of catecholamine-responsive adenylate cyclase during maturation of the rat reticulocyte.
Molecular pharmacology 1977;13(5):786-95.
1977: J P Bilezikian; Allen Spiegel; E M Brown; G D Aurbach
Identification and persistence of beta adrenergic receptors during maturation of the rat reticulocyte.
Molecular pharmacology 1977;13(5):775-85.
1977: Allen Spiegel; Robert Downs; G D Aurbach
Guanosine 5', alpha-beta-methylene, triphosphate, a novel GTP analog, causes persistent activation of adenylate cyclase: evidence against pyrophosphorylation mechanism.
Biochemical and biophysical research communications 1977;76(3):758-64.
1977: S J Marx; Allen Spiegel; E M Brown; G D Aurbach
Family studies in patients with primary parathyroid hyperplasia.
The American journal of medicine 1977;62(5):698-706.
1977: R H Gerner; R M Post; Allen Spiegel; D L Murphy
Effects of parathormone and lithium treatment on calcium and mood in depressed patients.
Biological psychiatry 1977;12(1):145-51.
1977: Allen Spiegel; H E Harrison; S J Marx; E M Brown; G D Aurbach
Neonatal primary hyperparathyroidism with autosomal dominant inheritance.
The Journal of pediatrics 1977;90(2):269-72.
1976: Allen Spiegel; R H Gerner; D L Murphy; G D Aurbach
Lithium does not inhibit the parathyroid hormone-mediated rise in urinary cyclic AMP and phosphate in humans.
The Journal of clinical endocrinology and metabolism 1976;43(6):1390-3.
1976: Allen Spiegel; E M Brown; G D Aurbach
Inhibition of adenylate cyclase by arsenite and cadmium: evidence for a vicinal dithiol requirement.
Journal of cyclic nucleotide research 1976;2(6):393-404.
1976: Allen Spiegel; G Di Chiro; P Gorden; A K Ommaya; J Kolins; T C Pomeroy
Diagnosis of radiosensitive hypothalamic tumors without craniotomy: endocrine and neuroradiologic studies of intracranial atypical teratomas.
Annals of internal medicine 1976;85(3):290-3.
1976: Allen Spiegel; E M Brown; S A Fedak; C J Woodard; G D Aurbach
Holocatalytic state of adenylate cyclase in turkey erythrocyte membranes: formation with guanylylimidodiphosphate plus isoproterenol without effect on affinity of beta-receptor.
Journal of cyclic nucleotide research 1976;2(1):47-56.
1976: J D Gardner; G D Aurbach; Allen Spiegel; E M Brown
Receptor function and ion transport in turkey erythrocytes.
Recent progress in hormone research 1976;32():567-95.
1975: Allen Spiegel; S J Marx; J L Doppman; R M Beazley; A S Ketcham; B Kasten; G D Aurbach
Intrathyroidal parathyroid adenoma or hyperplasia. An occasionally overlooked cause of surgical failure in primary hyperparathyroidism.
JAMA : the journal of the American Medical Association 1975;234(10):1029-33.
1975: J L Doppman; S J Marx; Allen Spiegel; L E Mallette; D R Wolfe; G D Aurbach; G Geelhoed
Treatment of hyperparathyroidism by percutaneous embolization of a mediastinal adenoma.
Radiology 1975;115(1):37-42.
1975: J L Doppman; L E Mallette; S J Marx; J M Monchik; A Broadus; Allen Spiegel; R Beazley; G D Aurbach
The localization of abnormal mediastinal parathyroid glands.
Radiology 1975;115(1):31-6.
1975: G D Aurbach; Allen Spiegel; J D Gardner
Beta-adrenergic receptors, cyclic AMP, and ion transport in the avian erythrocyte.
Advances in cyclic nucleotide research 1975;5():117-32.
1974: Allen Spiegel; G D Aurbach
Binding of 5'-guanylyl-imidodiphosphate to turkey erythrocyte membranes and effects on beta-adrenergic-activated adenylate cyclase.
The Journal of biological chemistry 1974;249(23):7630-6.
1974: S J Marx; J L Doppman; Allen Spiegel; D Wolfe; G D Aurbach
Embolization of a mediastinal parathyroid adenoma.
The Journal of clinical endocrinology and metabolism 1974;39(6):1110-4.
1969: Allen Spiegel; M W Bitensky
Effects of chemical and enzymatic modifications of glucagon on its activation of hepatic adenyl cyclase.
Endocrinology 1969;85(4):638-43.