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Johan Lennartsson

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Masoud Razmara; Carl-Henrik Heldin; Johan Lennartsson
Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D.
Xuping Wu; Michael Bergqvist; Stefan Bergström; Joachim Gullbo; Johan Lennartsson; Linda Sooman; Simon Ekman
Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells.
Lina Ekerljung; Johan Lennartsson; Lars Gedda
The HER2-binding affibody molecule (Z(HER2∶342))₂ increases radiosensitivity in SKBR-3 cells.

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All Publications

2013: Masoud Razmara; Carl-Henrik Heldin; Johan Lennartsson
Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D.
Cell communication and signaling : CCS 2013;11(1):3.
2013: Xuping Wu; Michael Bergqvist; Stefan Bergström; Joachim Gullbo; Johan Lennartsson; Linda Sooman; Simon Ekman
Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells.
International journal of oncology 2013;42(1):297-304.
2012: Lina Ekerljung; Johan Lennartsson; Lars Gedda
The HER2-binding affibody molecule (Z(HER2∶342))₂ increases radiosensitivity in SKBR-3 cells.
PloS one 2012;7(11):e49579.
2012: Sara Häggblad Sahlberg; Johan Lennartsson; Peter Nygren; Diana Spiegelberg; Bengt Glimelius; Bo Stenerlöw
The effect of a dimeric Affibody molecule (ZEGFR:1907)2 targeting EGFR in combination with radiation in colon cancer cell lines.
International journal of oncology 2012;40(1):176-84.
2011: Wei Zheng; Johan Lennartsson; Wiljan Hendriks; Carl-Henrik Heldin; Carina Hellberg
The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity.
Cellular signalling 2011;23(6):1050-6.
2010: Margrét Agnarsdóttir; Linda Sooman; Asa Bolander; Siv Strömberg; Elton Rexhepaj; Michael Bergqvist; Fredrik Ponten; William Gallagher; Johan Lennartsson; Simon Ekman; Mathias Uhlen; Håkan Hedstrand
SOX10 expression in superficial spreading and nodular malignant melanomas.
Melanoma research 2010;20(6):468-78.
2010: Piotr Wardega; Carl-Henrik Heldin; Johan Lennartsson
Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
Cellular signalling 2010;22(9):1363-8.
2010: Xu Hou; Anil Kumar; Chunsik Lee; Bin Wang; Pachiappan Arjunan; Lijin Dong; Arvydas Maminishkis; Zhongshu Tang; Yang Li; Fan Zhang; Shi-Zhuang Zhang; Piotr Wardega; Sagarika Chakrabarty; Baoying Liu; Zhijian Wu; Peter Colosi; Robert Fariss; Johan Lennartsson; Robert Nussenblatt; J Silvio Gutkind; Yihai Cao; Xuri Li
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(27):12216-21.
2010: Johan Lennartsson; Fatima Burovic; Barbara Witek; Aleksandra Jurek; Carl-Henrik Heldin
Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis.
Cellular signalling 2010;22(6):955-60.
2010: Zhongshu Tang; Pachiappan Arjunan; Chunsik Lee; Yang Li; Anil Kumar; Xu Hou; Bin Wang; Piotr Wardega; Fan Zhang; Lijin Dong; Yongqing Zhang; Shi-Zhuang Zhang; Hao Ding; Robert Fariss; Kevin G Becker; Johan Lennartsson; Nobuo Nagai; Yihai Cao; Xuri Li
Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation.
The Journal of experimental medicine 2010;207(4):867-80.
2010: Erika Nordberg; L Ekerljung; S H Sahlberg; Jörgen Carlsson; Johan Lennartsson; Bengt Glimelius
Effects of an EGFR-binding affibody molecule on intracellular signaling pathways.
International journal of oncology 2010;36(4):967-72.
2010: Simon Ekman; Michael Bergqvist; Roger Tell; Stefan Bergström; Johan Lennartsson
Hsp90 as a therapeutic target in patients with oesophageal carcinoma.
Expert opinion on therapeutic targets 2010;14(3):317-28.
2009: Fan Zhang; Zhongshu Tang; Xu Hou; Johan Lennartsson; Yang Li; Alexander W Koch; Pierre Scotney; Chunsik Lee; Pachiappan Arjunan; Lijin Dong; Anil Kumar; Tuomas T Rissanen; Bin Wang; Nobuo Nagai; Pierre Fons; Robert Fariss; Yongqing Zhang; Eric F Wawrousek; Ginger Tansey; James Raber; Guo-Hua Fong; Hao Ding; David A Greenberg; Kevin G Becker; Jean-Marc Herbert; Andrew Nash; Seppo Yla-Herttuala; Yihai Cao; Ryan J Watts; Xuri Li
VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(15):6152-7.
2009: Jean-François Classen; Dan Henrohn; Fredrik Rorsman; Johan Lennartsson; Bernard R Lauwerys; Gerhard Wikström; Charlotte Rorsman; Sandrine Lenglez; Karin Franck-Larsson; Jean-Paul Tomasi; Olle Kämpe; Marie Vanthuyne; Frédéric A Houssiau; Jean-Baptiste Demoulin
Lack of evidence of stimulatory autoantibodies to platelet-derived growth factor receptor in patients with systemic sclerosis.
Arthritis and rheumatism 2009;60(4):1137-44.
2009: Aleksandra Jurek; Kenichi Amagasaki; Agnieszka Gembarska; Carl-Henrik Heldin; Johan Lennartsson
Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation.
The Journal of biological chemistry 2009;284(7):4626-34.
2009: Xiongyu Wu; A Wanders; P Wardega; B Tinge; Lars Gedda; S Bergstrom; L Sooman; Joachim Gullbo; Michael Bergqvist; Patrik Hesselius; Johan Lennartsson; Stina Ekman
Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin.
British journal of cancer 2009;100(2):334-43.
2008: Lina Ekerljung; Malin Lindborg; Lars Gedda; Fredrik Y Frejd; Jörgen Carlsson; Johan Lennartsson
Dimeric HER2-specific affibody molecules inhibit proliferation of the SKBR-3 breast cancer cell line.
Biochemical and biophysical research communications 2008;377(2):489-94.
2008: Simon Ekman; Martin Dreilich; Johan Lennartsson; Bengt Wallner; Daniel Brattström; Magnus Sundbom; Michael Bergqvist
Esophageal cancer: current and emerging therapy modalities.
Expert review of anticancer therapy 2008;8(9):1433-48.
2008: Gerli Rosengren Pielberg; Anna Golovko; Elisabeth Sundström; Ino Curik; Johan Lennartsson; Monika H Seltenhammer; Thomas Druml; Matthew Binns; Carolyn Fitzsimmons; Gabriella Lindgren; Kaj Sandberg; Roswitha Baumung; Monika Vetterlein; Sara Strömberg; Manfred Grabherr; Claire Wade; Kerstin Lindblad-Toh; Fredrik Pontén; Carl-Henrik Heldin; Johann Sölkner; Leif Andersson
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse.
Nature genetics 2008;40(8):1004-9.
2008: Yang Li; Fan Zhang; Nobuo Nagai; Zhongshu Tang; Shuihua Zhang; Pierre Scotney; Johan Lennartsson; Chaoyong Zhu; Yi Qu; Changge Fang; Jianyuan Hua; Osamu Matsuo; Guo-Hua Fong; Hao Ding; Yihai Cao; Kevin G Becker; Andrew Nash; Carl-Henrik Heldin; Xuri Li
VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.
The Journal of clinical investigation 2008;118(3):913-23.
2007: Simon Ekman; Michael Bergqvist; Carl-Henrik Heldin; Johan Lennartsson
Activation of growth factor receptors in esophageal cancer--implications for therapy.
The oncologist 2007;12(10):1165-77.
2006: Johan Lennartsson; Piotr Wardega; Ulla Engström; Ulf Hellman; Carl-Henrik Heldin
Alix facilitates the interaction between c-Cbl and platelet-derived growth factor beta-receptor and thereby modulates receptor down-regulation.
The Journal of biological chemistry 2006;281(51):39152-8.
2006: Kenichi Amagasaki; Hideaki Kaneto; Carl-Henrik Heldin; Johan Lennartsson
c-Jun N-terminal kinase is necessary for platelet-derived growth factor-mediated chemotaxis in primary fibroblasts.
The Journal of biological chemistry 2006;281(31):22173-9.
2006: Johan Lennartsson; Lars Rönnstrand
The stem cell factor receptor/c-Kit as a drug target in cancer.
Current cancer drug targets 2006;6(1):65-75.
2006: Thomas Strömberg; Simon Ekman; Leonard Girnita; Lina Dimberg; Olle Larsson; Magnus Axelson; Johan Lennartsson; Ulf Hellman; Kristina Carlson; Anders Osterborg; Karin Vanderkerken; Kenneth Nilsson; Helena Jernberg-Wiklund
IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.
Blood 2006;107(2):669-78.
2006: Lina Ekerljung; Ann-Charlott Steffen; Jörgen Carlsson; Johan Lennartsson
Effects of HER2-binding affibody molecules on intracellular signaling pathways.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2006;27(4):201-10.
2005: Christine Möller; Jessica Alfredsson; Maria Kraft; Hanna Wootz; Zou Xiang; Johan Lennartsson; Jan-Ingvar Jönsson; Gunnar Nilsson
Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.
Blood 2005;106(4):1330-6.
2005: Xuri Li; Marc Tjwa; Lieve Moons; Pierre Fons; Agnès Noel; Annelii Ny; Jian Min Zhou; Johan Lennartsson; Hong Li; Aernout Luttun; Annica Pontén; Laetitia Devy; Ann Bouché; Hideyasu Oh; Ann Manderveld; Silvia Blacher; David Communi; Pierre Savi; Françoise Bono; Mieke Dewerchin; Jean-Michel Foidart; Monica Autiero; Jean-Marc Herbert; Désiré Collen; Carl-Henrik Heldin; Ulf Eriksson; Peter Carmeliet
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors.
The Journal of clinical investigation 2005;115(1):118-27.
2005: Johan Lennartsson; Tanya Jelacic; Diana Linnekin; R Shivakrupa
Normal and oncogenic forms of the receptor tyrosine kinase kit.
Stem cells (Dayton, Ohio) 2005;23(1):16-43.
2004: Johan Lennartsson; R Shivakrupa; Diana Linnekin
Synergistic growth of stem cell factor and granulocyte macrophage colony-stimulating factor involves kinase-dependent and -independent contributions from c-Kit.
The Journal of biological chemistry 2004;279(43):44544-53.
2003: Johan Lennartsson; Christer Wernstedt; Ulla Engström; Ulf Hellman; Lars Rönnstrand
Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.
Experimental cell research 2003;288(1):110-8.
2003: Patrik Wollberg; Johan Lennartsson; Eva Gottfridsson; Akihiko Yoshimura; Lars Rönnstrand
The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.
The Biochemical journal 2003;370(Pt 3):1033-8.
2003: Olexandr Voytyuk; Johan Lennartsson; Akira Mogi; Georgina Caruana; Sara Courtneidge; Leonie K Ashman; Lars Rönnstrand
Src family kinases are involved in the differential signaling from two splice forms of c-Kit.
The Journal of biological chemistry 2003;278(11):9159-66.
2003: Beston F Nore; Pekka T Mattsson; Per Antonsson; Carl-Magnus Bäckesjö; Anna Westlund; Johan Lennartsson; Henrik Hansson; Peter Löw; Lars Rönnstrand; C I Edvard Smith
Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
Biochimica et biophysica acta 2003;1645(2):123-32.
2002: Maria Hägg; Asa Liljegren; Jörgen Carlsson; Lars Rönnstrand; Johan Lennartsson
EGF and dextran-conjugated EGF induces differential phosphorylation of the EGF receptor.
International journal of molecular medicine 2002;10(5):655-9.
2000: Karen E Anderson; Peter Lipp; Martin D Bootman; SH Ridley; John Coadwell; L Rönnstrand; Johan Lennartsson; Andrew B Holmes; GF Painter; Jan W Thuring; Ze-Yi Lim; Hediye Erdjument-Bromage; A Grewal; Paul Tempst; Len R Stephens; Phillip T Hawkins
DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation.
Current biology : CB 2000;10(22):1403-12.
1999: Johan Lennartsson; P Blume-Jensen; M Hermanson; E Pontén; M Carlberg; Lars Rönnstrand
Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction.
Oncogene 1999;18(40):5546-53.
1999: K Thömmes; Johan Lennartsson; M Carlberg; Lars Rönnstrand
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
The Biochemical journal 1999;341 ( Pt 1)():211-6.