Doug Cyr

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Cyr Douglas M; Hebert Daniel N
Protein quality control--linking the unfolded protein response to disease. Conference on 'From Unfolded Proteins in the Endoplasmic Reticulum to Disease'.
Douglas Peter M; Summers Daniel W; Ren Hong-Yu; Cyr Douglas M
Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
Grove Diane E; Rosser Meredith F N; Ren Hong Yu; Naren Anjaparavanda P; Cyr Douglas M
Mechanisms for rescue of correctable folding defects in CFTR{Delta}F508.

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All Publications

2009: Cyr Douglas M; Hebert Daniel N
Protein quality control--linking the unfolded protein response to disease. Conference on 'From Unfolded Proteins in the Endoplasmic Reticulum to Disease'.
EMBO reports 2009;10(11):1206-10.
2009: Douglas Peter M; Summers Daniel W; Ren Hong-Yu; Cyr Douglas M
Reciprocal efficiency of RNQ1 and polyglutamine detoxification in the cytosol and nucleus.
Molecular biology of the cell 2009;20(19):4162-73.
2009: Grove Diane E; Rosser Meredith F N; Ren Hong Yu; Naren Anjaparavanda P; Cyr Douglas M
Mechanisms for rescue of correctable folding defects in CFTR{Delta}F508.
Molecular biology of the cell 2009;20(18):4059-69.
2009: Kota Pradeep; Summers Daniel W; Ren Hong-Yu; Cyr Douglas M; Dokholyan Nikolay V
Identification of a consensus motif in substrates bound by a Type I Hsp40.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11073-8.
2009: McDonough Holly; Charles Peter C; Hilliard Eleanor G; Qian Shu-Bing; Min Jin-Na; Portbury Andrea; Cyr Douglas M; Patterson Cam
Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.
The Journal of biological chemistry 2009;284(31):20649-59.
2009: Treusch Sebastian; Cyr Douglas M; Lindquist Susan
Amyloid deposits: protection against toxic protein species?
Cell cycle (Georgetown, Tex.) 2009;8(11):1668-74.
2009: Summers Daniel W; Douglas Peter M; Ramos Carlos H I; Cyr Douglas M
Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones.
Trends in biochemical sciences 2009;34(5):230-3.
2009: Summers Daniel W; Douglas Peter M; Cyr Douglas M
Prion propagation by Hsp40 molecular chaperones.
Prion 2009;3(2):59-64.
2009: Douglas Peter M; Summers Daniel W; Cyr Douglas M
Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways.
Prion 2009;3(2):51-8.
2009: Summers Daniel W; Douglas Peter M; Ren Hong-Yu; Cyr Douglas M
The type I Hsp40 Ydj1 utilizes a farnesyl moiety and zinc finger-like region to suppress prion toxicity.
The Journal of biological chemistry 2009;284(6):3628-39.
2008: Rosser Meredith F N; Grove Diane E; Chen Liling; Cyr Douglas M
Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2.
Molecular biology of the cell 2008;19(11):4570-9.
2008: Ramos Carlos H I; Oliveira Cristiano L P; Fan Chung-Yang; Torriani Iris L; Cyr Douglas M
Conserved central domains control the quaternary structure of type I and type II Hsp40 molecular chaperones.
Journal of molecular biology 2008;383(1):155-66.
2008: Cyr Douglas M
Swapping nucleotides, tuning Hsp70.
Cell 2008;133(6):945-7.
2008: Douglas Peter M; Treusch Sebastian; Ren Hong-Yu; Halfmann Randal; Duennwald Martin L; Lindquist Susan; Cyr Douglas M
Chaperone-dependent amyloid assembly protects cells from prion toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(20):7206-11.
2008: Morito Daisuke; Hirao Kazuyoshi; Oda Yukako; Hosokawa Nobuko; Tokunaga Fuminori; Cyr Douglas M; Tanaka Keiji; Iwai Kazuhiro; Nagata Kazuhiro
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.
Molecular biology of the cell 2008;19(4):1328-36.
2008: Hirayama Shoshiro; Yamazaki Yuji; Kitamura Akira; Oda Yukako; Morito Daisuke; Okawa Katsuya; Kimura Hiroshi; Cyr Douglas M; Kubota Hiroshi; Nagata Kazuhiro
MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination.
Molecular biology of the cell 2008;19(3):899-911.
2007: Rosser Meredith F N; Washburn Erin; Muchowski Paul J; Patterson Cam; Cyr Douglas M
Chaperone functions of the E3 ubiquitin ligase CHIP.
The Journal of biological chemistry 2007;282(31):22267-77.
2007: Turnbull Emma L; Rosser Meredith F N; Cyr Douglas M
The role of the UPS in cystic fibrosis.
BMC biochemistry 2007;8 Suppl 1():S11.
2006: Younger J Michael; Chen Liling; Ren Hong-Yu; Rosser Meredith F N; Turnbull Emma L; Fan Chun-Yang; Patterson Cam; Cyr Douglas M
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.
Cell 2006;126(3):571-82.
2006: Qian Shu-Bing; McDonough Holly; Boellmann Frank; Cyr Douglas M; Patterson Cam
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70.
Nature 2006;440(7083):551-5.
2005: Dai Qian; Qian Shu-Bing; Li Hui-Hua; McDonough Holly; Borchers Christoph; Huang David; Takayama Shinichi; Younger J Michael; Ren Hong Yu; Cyr Douglas M; Patterson Cam
Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.
The Journal of biological chemistry 2005;280(46):38673-81.
2005: Cyr Douglas M
Arrest of CFTRDeltaF508 folding.
Nature structural & molecular biology 2005;12(1):2-3.
2005: Fan Chun-Yang; Ren Hong-Yu; Lee Paul; Caplan Avrom J; Cyr Douglas M
The type I Hsp40 zinc finger-like region is required for Hsp70 to capture non-native polypeptides from Ydj1.
The Journal of biological chemistry 2005;280(1):695-702.
2005: Younger J Michael; Fan Chun-Yang; Chen Liling; Rosser Meredith F N; Patterson Cam; Cyr Douglas M
Cystic fibrosis transmembrane conductance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2005;301():293-303.
2004: Younger J Michael; Ren Hong-Yu; Chen Liling; Fan Chun-Yang; Fields Andrea; Patterson Cam; Cyr Douglas M
A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.
The Journal of cell biology 2004;167(6):1075-85.
2004: Fan Chun-Yang; Lee Soojin; Ren Hong-Yu; Cyr Douglas M
Exchangeable chaperone modules contribute to specification of type I and type II Hsp40 cellular function.
Molecular biology of the cell 2004;15(2):761-73.
2004: Dalal Seema; Rosser Meredith F N; Cyr Douglas M; Hanson Phyllis I
Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway.
Molecular biology of the cell 2004;15(2):637-48.
2003: Fan Chun-Yang; Lee Soojin; Cyr Douglas M
Mechanisms for regulation of Hsp70 function by Hsp40.
Cell stress & chaperones 2003;8(4):309-16.
2002: Cyr Douglas M; Höhfeld Jörg; Patterson Cam
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold.
Trends in biochemical sciences 2002;27(7):368-75.
2002: Lee Soojin; Fan Chun Yang; Younger J Michael; Ren Hongyu; Cyr Douglas M
Identification of essential residues in the type II Hsp40 Sis1 that function in polypeptide binding.
The Journal of biological chemistry 2002;277(24):21675-82.
2002: Meacham Geoffrey C; Cyr Douglas M
Isolation of CFTR. Chaperone complexes by co-immunoprecipitation.
Methods in molecular medicine 2002;70():245-56.
2001: Jiang J; Ballinger C A; Wu Y; Dai Q; Cyr D M; Höhfeld J; Patterson C
CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.
The Journal of biological chemistry 2001;276(46):42938-44.
2001: Höhfeld J; Cyr D M; Patterson C
From the cradle to the grave: molecular chaperones that may choose between folding and degradation.
EMBO reports 2001;2(10):885-90.
2001: Meacham G C; Patterson C; Zhang W; Younger J M; Cyr D M
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation.
Nature cell biology 2001;3(1):100-5.
2000: Gall W E; Higginbotham M A; Chen C; Ingram M F; Cyr D M; Graham T R
The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast.
Current biology : CB 2000;10(21):1349-58.
2000: Sha B; Lee S; Cyr D M
The crystal structure of the peptide-binding fragment from the yeast Hsp40 protein Sis1.
Structure (London, England : 1993) 2000;8(8):799-807.
1999: Meacham G C; Browne B L; Zhang W; Kellermayer R; Bedwell D M; Cyr D M
Mutations in the yeast Hsp40 chaperone protein Ydj1 cause defects in Axl1 biogenesis and pro-a-factor processing.
The Journal of biological chemistry 1999;274(48):34396-402.
1999: Meacham G C; Lu Z; King S; Sorscher E; Tousson A; Cyr D M
The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis.
The EMBO journal 1999;18(6):1492-505.
1998: Liu J S; Kuo S R; Makhov A M; Cyr D M; Griffith J D; Broker T R; Chow L T
Human Hsp70 and Hsp40 chaperone proteins facilitate human papillomavirus-11 E1 protein binding to the origin and stimulate cell-free DNA replication.
The Journal of biological chemistry 1998;273(46):30704-12.
1998: Lu Z; Cyr D M
Protein folding activity of Hsp70 is modified differentially by the hsp40 co-chaperones Sis1 and Ydj1.
The Journal of biological chemistry 1998;273(43):27824-30.
1998: Lu Z; Cyr D M
The conserved carboxyl terminus and zinc finger-like domain of the co-chaperone Ydj1 assist Hsp70 in protein folding.
The Journal of biological chemistry 1998;273(10):5970-8.
1997: Cyr D M
Coupling chemical energy by the hsp70/tim44 complex to drive protein translocation into mitochondria.
Journal of bioenergetics and biomembranes 1997;29(1):29-34.
1996: Ungermann C; Guiard B; Neupert W; Cyr D M
The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria.
The EMBO journal 1996;15(4):735-44.
1996: Cyr D M; Neupert W
Roles for hsp70 in protein translocation across membranes of organelles.
EXS 1996;77():25-40.
1995: Cyr D M
Cooperation of the molecular chaperone Ydj1 with specific Hsp70 homologs to suppress protein aggregation.
FEBS letters 1995;359(2-3):129-32.
1995: Cyr D M; Ungermann C; Neupert W
Analysis of mitochondrial protein import pathway in Saccharomyces cerevisiae with translocation intermediates.
Methods in enzymology 1995;260():241-52.
1994: Stuart R A; Cyr D M; Neupert W
Hsp70 in mitochondrial biogenesis: from chaperoning nascent polypeptide chains to facilitation of protein degradation.
Experientia 1994;50(11-12):1002-11.
1994: Ungermann C; Neupert W; Cyr D M
The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria.
Science (New York, N.Y.) 1994;266(5188):1250-3.
1994: Cyr D M; Douglas M G
Differential regulation of Hsp70 subfamilies by the eukaryotic DnaJ homologue YDJ1.
The Journal of biological chemistry 1994;269(13):9798-804.
1994: Cyr D M; Langer T; Douglas M G
DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70.
Trends in biochemical sciences 1994;19(4):176-81.
1994: Stuart R A; Cyr D M; Craig E A; Neupert W
Mitochondrial molecular chaperones: their role in protein translocation.
Trends in biochemical sciences 1994;19(2):87-92.
1993: Cyr D M; Stuart R A; Neupert W
A matrix ATP requirement for presequence translocation across the inner membrane of mitochondria.
The Journal of biological chemistry 1993;268(32):23751-4.
1993: Caplan A J; Cyr D M; Douglas M G
Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins.
Molecular biology of the cell 1993;4(6):555-63.
1992: Caplan A J; Cyr D M; Douglas M G
YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.
Cell 1992;71(7):1143-55.
1992: Cyr D M; Lu X; Douglas M G
Regulation of Hsp70 function by a eukaryotic DnaJ homolog.
The Journal of biological chemistry 1992;267(29):20927-31.
1991: Cyr D M; Douglas M G
Early events in the transport of proteins into mitochondria. Import competition by a mitochondrial presequence.
The Journal of biological chemistry 1991;266(32):21700-8.
1991: Hoyt D W; Cyr D M; Gierasch L M; Douglas M G
Interaction of peptides corresponding to mitochondrial presequences with membranes.
The Journal of biological chemistry 1991;266(32):21693-9.
1991: Cyr D M; Egan S G; Brini C M; Tremblay G C
On the mechanism of inhibition of gluconeogenesis and ureagenesis by sodium benzoate.
Biochemical pharmacology 1991;42(3):645-54.
1990: Mangel W F; Singer P T; Cyr D M; Umland T C; Toledo D L; Stroud R M; Pflugrath J W; Sweet R M
Structure of an acyl-enzyme intermediate during catalysis: (guanidinobenzoyl)trypsin.
Biochemistry 1990;29(36):8351-7.
1989: Cyr D M; Tremblay G C
On combination therapy with benzoate and piridoxilate.
American journal of diseases of children (1960) 1989;143(12):1392.
1989: Cyr D M; Tremblay G C
Potentiation of benzoate toxicity by glyoxylate. Inhibition of pyruvate carboxylase and the urea cycle.
Biochemical pharmacology 1989;38(17):2919-23.
1989: Griffith A D; Cyr D M; Egan S G; Tremblay G C
Inhibition of pyruvate carboxylase by sequestration of coenzyme A with sodium benzoate.
Archives of biochemistry and biophysics 1989;269(1):201-7.
1986: Maswoswe S M; Cyr D M; Griffith A D; Tremblay G C
The effect of sodium benzoate on ammonia toxicity in rats.
Biochemical and biophysical research communications 1986;138(1):369-73.

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