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Alexandra Zhernakova

Research Profile

Genes & Molecular Sequences

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Diederik P C de Rooy; Jeanine J Houwing-Duistermaat; Tom W J Huizinga; Rachel Knevel; Annemarie Krabben; Martha K Leijsma; Elisabet Lindqvist; Tore Saxne; René E M Toes; S Tsonaka; Dominique L P Baeten; Elisabeth Brouwer; Nina A Daha; Anthony Gerard Wilson; Nataliya G Yeremenko; Alexandra Zhernakova; Annette H M Van Der Helm-Van Mil
Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.
R Knevel; A Krabben; M K Leijsma; E Lindqvist; Tore Saxne; R E M Toes; S Tsonaka; E Brouwer; N A Daha; D P C de Rooy; Lude Franke; Jeanine J Houwing-Duistermaat; T W J Huizinga; M P M van der Linden; Harm-Jan Westra; A G Wilson; Alexandra Zhernakova; Annette H M Van Der Helm-Van Mil
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis.
Vinod Kumar; Andres Metspalu; Eva Reinmaa; Urmo Võsa; Harm-Jan Westra; Sebo Withoff; Alexandra Zhernakova; Daria V Zhernakova; Rodrigo Almeida; Tõnu Esko; Rudolf S N Fehrmann; Lude Franke; Jingyuan Fu; Marten H Hofker; Barbara Hrdlickova; Juha Karjalainen; Cisca Wijmenga
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.

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All Publications

2013: Diederik P C de Rooy; Jeanine J Houwing-Duistermaat; Tom W J Huizinga; Rachel Knevel; Annemarie Krabben; Martha K Leijsma; Elisabet Lindqvist; Tore Saxne; René E M Toes; S Tsonaka; Dominique L P Baeten; Elisabeth Brouwer; Nina A Daha; Anthony Gerard Wilson; Nataliya G Yeremenko; Alexandra Zhernakova; Annette H M Van Der Helm-Van Mil
Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.
Annals of the rheumatic diseases 2013;72(5):769-75.
2013: R Knevel; A Krabben; M K Leijsma; E Lindqvist; Tore Saxne; R E M Toes; S Tsonaka; E Brouwer; N A Daha; D P C de Rooy; Lude Franke; Jeanine J Houwing-Duistermaat; T W J Huizinga; M P M van der Linden; Harm-Jan Westra; A G Wilson; Alexandra Zhernakova; Annette H M Van Der Helm-Van Mil
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis.
Arthritis and rheumatism 2013;65(3):582-9.
2013: Vinod Kumar; Andres Metspalu; Eva Reinmaa; Urmo Võsa; Harm-Jan Westra; Sebo Withoff; Alexandra Zhernakova; Daria V Zhernakova; Rodrigo Almeida; Tõnu Esko; Rudolf S N Fehrmann; Lude Franke; Jingyuan Fu; Marten H Hofker; Barbara Hrdlickova; Juha Karjalainen; Cisca Wijmenga
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
PLoS genetics 2013;9(1):e1003201.
2012: R Knevel; E Lindqvist; Tore Saxne; Kristjan Steinsson; René E M Toes; R Tsonaka; D P de Rooy; Peter K Gregersen; Gerdur Gröndal; Jeanine J Houwing-Duistermaat; Tom W J Huizinga; J A van Nies; A G Wilson; Alexandra Zhernakova; Annette H M Van Der Helm-Van Mil
Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts.
Annals of the rheumatic diseases 2012;71(10):1753-5.
2011: Jihua Shi; Gang Sun; Gerard Dijkstra; Klaas Nico Faber; Xinghua Lu; Xuejun Ma; Jiaming Qian; Cisca Wijmenga; Alexandra Zhernakova; Lu Zhou; Feng Zhu; Liming Zhu; Rinse Weersma
Haplotype-based analysis of ulcerative colitis risk loci identifies both IL2 and IL21 as susceptibility genes in Han Chinese.
Inflammatory bowel diseases 2011;17(12):2472-9.
2011: Rudolf S N Fehrmann; Eleanora M Festen; Danny Arends; Marc Jan Bonder; Wim A Buurman; Patrick Deelen; Clara C Elbers; Jingyuan Fu; Harry J M Groen; Marten H Hofker; Robert M W Hofstra; Ritsert C Jansen; Roel A Ophoff; Mathieu Platteel; Sander Rensen; Christiaan G J Saris; Asia Smolonska; Gerard J Te Meerman; Gosia Trynka; Leonard H van den Berg; David A van Heel; Jan H Veldink; Rinse Weersma; Harm-Jan Westra; Cisca Wijmenga; Marcel G M Wolfs; Alexandra Zhernakova; Lude Franke
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
PLoS genetics 2011;7(8):e1002197.
2011: Elisabet Einarsdottir; Katri Kaukinen; Juha Kere; Ilma Korponay-Szabo; Lotta L E Koskinen; Kalle Kurppa; Markku Mäki; M Luisa Mearin; Alienke Monsuur; Chris Mulder; Ruben van't Slot; Cisca Wijmenga; Alexandra Zhernakova; Marianna R Bevova; Päivi Saavalainen
Multiple independent variants in 6q21-22 associated with susceptibility to celiac disease in the Dutch, Finnish and Hungarian populations.
European journal of human genetics : EJHG 2011;19(6):682-6.
2010: Alexandra Zhernakova; Clara C Elbers; Bart Ferwerda; Jihane Romanos; Gosia Trynka; Patrick C Dubois; Carolien G F de Kovel; Lude Franke; Marije Oosting; Donatella Barisani; Maria Teresa Bardella; Leo A B Joosten; Paivi Saavalainen; David A van Heel; Carlo Catassi; Mihai G Netea; Cisca Wijmenga
Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.
American journal of human genetics 2010;86(6):970-7.
2010: Victorien M Wolters; Behrooz Z Alizadeh; Michel E Weijerman; Alexandra Zhernakova; Ingrid M W van Hoogstraten; M Luisa Mearin; Martin C Wapenaar; Cisca Wijmenga; Marco W J Schreurs
Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability.
Human immunology 2010;71(4):392-6.
2010: A F Baas; J Medic; Ruben van 't Slot; Carolien G F de Kovel; Alexandra Zhernakova; R H Geelkerken; S E Kranendonk; Steven M M van Sterkenburg; Diederick Grobbee; A P Boll; Cisca Wijmenga; Jan D Blankensteijn; Ynte M Ruigrok
Association of the TGF-beta receptor genes with abdominal aortic aneurysm.
European journal of human genetics : EJHG 2010;18(2):240-4.
2010: Rute B Marques; Mohamed M Thabet; Stefan J White; Jeanine J Houwing-Duistermaat; Aleida M Bakker; Gert-Jan Hendriks; Alexandra Zhernakova; Tom W Huizinga; Annette H M Van Der Helm-Van Mil; René E M Toes
Genetic variation of the Fc gamma receptor 3B gene and association with rheumatoid arthritis.
PloS one 2010;5(10):.
2009: Marieke Coenen; Gosia Trynka; Sandra Heskamp; Barbara Franke; Cleo C van Diemen; Joanna Smolonska; Miek van Leeuwen; Elisabeth Brouwer; Marike H Boezen; Dirkje S Postma; Mathieu Platteel; Pieter Zanen; Jan-Willem W J Lammers; Harry J M Groen; Willem P T M Mali; Chris J Mulder; Greetje J Tack; Wieke H M Verbeek; Victorien M Wolters; Roderick H J Houwen; M Luisa Mearin; David A van Heel; Timothy R D J Radstake; Piet L C M van Riel; Cisca Wijmenga; Pilar Barrera; Alexandra Zhernakova
Common and different genetic background for rheumatoid arthritis and coeliac disease.
Human molecular genetics 2009;18(21):4195-203.
2009: Jihane Romanos; Cleo C van Diemen; Ilja M Nolte; Gosia Trynka; Alexandra Zhernakova; Jingyuan Fu; Maria Teresa Bardella; Donatella Barisani; Ross McManus; David A van Heel; Cisca Wijmenga
Analysis of HLA and non-HLA alleles can identify individuals at high risk for celiac disease.
Gastroenterology 2009;137(3):834-40, 840.e1-3.
2009: G Trynka; Alexandra Zhernakova; Jihane Romanos; Lude Franke; Karen A Hunt; G Turner; Marcel Bruinenberg; G A Heap; M Platteel; Anthony Ryan; C de Kovel; G K T Holmes; Peter Howdle; Julian R F Walters; D S Sanders; Chris J J Mulder; M L Mearin; W H M Verbeek; V Trimble; F M Stevens; D Kelleher; Donatella Barisani; Maria Teresa Bardella; Ross McManus; David A van Heel; Cisca Wijmenga
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Gut 2009;58(8):1078-83.
2009: E A M Festen; Philippe Goyette; R Scott; V Annese; Alexandra Zhernakova; J Lian; C Lefèbvre; Steven R Brant; Judy H Cho; Mark S Silverberg; Kent D Taylor; Dirk J de Jong; Pieter C F Stokkers; D Mcgovern; O Palmieri; J-P Achkar; Ramnik Xavier; Mark J Daly; Richard H Duerr; Cisca Wijmenga; Rinse Weersma; John D Rioux
Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
Gut 2009;58(6):799-804.
2009: Alexandra Zhernakova; Cleo C van Diemen; cisca wijmenga
Detecting shared pathogenesis from the shared genetics of immune-related diseases.
Nature reviews. Genetics 2009;10(1):43-55.
2009: Jihane Romanos; Donatella Barisani; G Trynka; Alexandra Zhernakova; M T Bardella; Cisca Wijmenga
Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.
Journal of medical genetics 2009;46(1):60-3.
2008: E A Festen; Alexandra Zhernakova; cisca wijmenga; Rinse Weersma
Association of DLG5 variants with gluten-sensitive enteropathy.
Gut 2008;57(7):1027-8.
2008: Lude Franke; Carolien G F de Kovel; Yurii Aulchenko; Gosia Trynka; Alexandra Zhernakova; Karen A Hunt; Hylke M Blauw; Leonard H Van den Berg; Roel Ophoff; Panos Deloukas; David A van Heel; Cisca Wijmenga
Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays.
American journal of human genetics 2008;82(6):1316-33.
2008: Alexandra Zhernakova; Eleanora M Festen; Lude Franke; Gosia Trynka; Cleo C van Diemen; Alienke J Monsuur; Marianna R Bevova; Rian M Nijmeijer; Ruben van 't Slot; Roel Heijmans; H Marike Boezen; David A van Heel; Ad van Bodegraven; Pieter C F Stokkers; Cisca Wijmenga; J Bart A Crusius; Rinse Weersma
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.
American journal of human genetics 2008;82(5):1202-10.
2008: Karen A Hunt; Alexandra Zhernakova; Graham Turner; Graham A R Heap; Lude Franke; Marcel Bruinenberg; Jihane Romanos; Lotte C Dinesen; Anthony Ryan; Davinder Panesar; Rhian Gwilliam; Fumihiko Takeuchi; William M McLaren; Geoffrey K T Holmes; Peter D Howdle; Julian R F Walters; David S Sanders; Raymond J Playford; Gosia Trynka; Chris J J Mulder; M Luisa Mearin; Wieke H M Verbeek; Valerie Trimble; Fiona M Stevens; Colm O'Morain; Nicholas P Kennedy; Dermot Kelleher; Daniel J Pennington; David P Strachan; Wendy L McArdle; Charles A Mein; Martin C Wapenaar; Panos Deloukas; Ralph McGinnis; Ross McManus; cisca wijmenga; David A van Heel
Newly identified genetic risk variants for celiac disease related to the immune response.
Nature genetics 2008;40(4):395-402.
2008: Rinse Weersma; Alexandra Zhernakova; Ilja M Nolte; Céline Lefebvre; John D Rioux; Flip Mulder; Hendrik M van Dullemen; Jan H Kleibeuker; Cisca Wijmenga; Gerard Dijkstra
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in the Netherlands.
The American journal of gastroenterology 2008;103(3):621-7.
2008: Alienke J Monsuur; Paul I W de Bakker; Alexandra Zhernakova; Dalila Pinto; Willem Verduijn; Jihane Romanos; Renata Auricchio; Ana Lopez; David A van Heel; J Bart A Crusius; Cisca Wijmenga
Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.
PloS one 2008;3(5):e2270.
2007: Alexandra Zhernakova; Behrooz Alizadeh; Marianna R Bevova; Miek A van Leeuwen; Marieke Coenen; Barbara Franke; Lude Franke; Marcel D Posthumus; David A van Heel; Gerrit van der Steege; Timothy Radstake; Pilar Barrera; Bart O Roep; Bobby P C Koeleman; Cisca Wijmenga
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
American journal of human genetics 2007;81(6):1284-8.
2007: Victorien M Wolters; Wieke H M Verbeek; Alexandra Zhernakova; Charlotte Onland-Moret; Marco W J Schreurs; Alienke J Monsuur; Willem Verduijn; Cisca Wijmenga; Chris J J Mulder
The MYO9B gene is a strong risk factor for developing refractory celiac disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007;5(12):1399-405, 1405.e1-2.
2007: Behrooz Alizadeh; Gustavo Valdigem; Marieke Coenen; Alexandra Zhernakova; Barbara Franke; Alienke J Monsuur; P L C M van Riel; Pilar Barrera; Timothy Radstake; Bart O Roep; Cisca Wijmenga; Bobby P C Koeleman
Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis.
Human molecular genetics 2007;16(21):2552-9.
2007: David A van Heel; Lude Franke; Karen A Hunt; Rhian Gwilliam; Alexandra Zhernakova; Mike Inouye; Martin C Wapenaar; M C N M Barnardo; Graeme Bethel; G K T Holmes; Conleth Feighery; Derek Jewell; Dermot Kelleher; Parveen Kumar; Simon Travis; Julian R F Walters; David S Sanders; Peter Howdle; Jill Swift; Raymond J Playford; William M McLaren; M Luisa Mearin; Chris J J Mulder; Ross McManus; Ralph McGinnis; Lon R Cardon; Panos Deloukas; Cisca Wijmenga
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
Nature genetics 2007;39(7):827-9.
2007: Behrooz Alizadeh; Peter Eerligh; Arno R van der Slik; Arun Shastry; Alexandra Zhernakova; Gustavo Valdigem; Jan G Bruining; Carani B Sanjeevi; Cisca Wijmenga; Bart O Roep; Bobby P C Koeleman
MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis.
Molecular immunology 2007;44(11):2806-12.
2007: Jana V van Vliet-Ostaptchouk; Ronit Shiri-Sverdlov; Alexandra Zhernakova; Eric Strengman; Timon W van Haeften; Marten H Hofker; Cisca Wijmenga
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
Diabetologia 2007;50(1):59-62.
2006: Alexandra Zhernakova; Behrooz Alizadeh; Peter Eerligh; Pejman Hanifi-Moghaddam; Nanette C Schloot; Begoña Diosdado; Cisca Wijmenga; Bart O Roep; Bobby P C Koeleman
Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.
Genes and immunity 2006;7(7):544-9.
2005: Alienke J Monsuur; Paul I W de Bakker; Behrooz Alizadeh; Alexandra Zhernakova; Marianna R Bevova; Eric Strengman; Lude Franke; Ruben van't Slot; Martine J Van Belzen; Ineke C M Lavrijsen; Begoña Diosdado; Mark J Daly; Chris J J Mulder; M Luisa Mearin; Jos W R Meijer; Gerrit A Meijer; Erica van Oort; Martin C Wapenaar; Bobby P C Koeleman; Cisca Wijmenga
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
Nature genetics 2005;37(12):1341-4.
2005: Alexandra Zhernakova; Peter Eerligh; Pilar Barrera; Joanna Wesoly; Joanna Z Weseloy; Tom W J Huizinga; Bart O Roep; Cisca Wijmenga; Bobby P C Koeleman
CTLA4 is differentially associated with autoimmune diseases in the Dutch population.
Human genetics 2005;118(1):58-66.
2005: Alexandra Zhernakova; Peter Eerligh; Cisca Wijmenga; Pilar Barrera; Bart O Roep; Bobby P C Koeleman
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Genes and immunity 2005;6(6):459-61.
2005: Blanca Rueda; Alexandra Zhernakova; Miguel A López-Nevot; Javier Martín; Bobby P C Koeleman
Association study of functional genetic variants of innate immunity related genes in celiac disease.
BMC medical genetics 2005;6():29.
2005: Blanca Rueda; Alexandra Zhernakova; Miguel A López-Nevot; M Gomez-Garcia; Eduardo Ortega; Alexis Piñero; Francisco Correro; José A Brieva; Antonio Nieto; Bobby P C Koeleman; Javier Martín
CTLA4/CT60 polymorphism is not relevant in susceptibility to autoimmune inflammatory intestinal disorders.
Human immunology 2005;66(3):321-5.
2004: Martine J Van Belzen; Chris J J Mulder; Alexandra Zhernakova; Peter L Pearson; Roderick H J Houwen; Cisca Wijmenga
CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients.
European journal of human genetics : EJHG 2004;12(9):782-5.
2003: Thomas Müller; Bart van De Sluis; Alexandra Zhernakova; Ellen van Binsbergen; Andreas R Janecke; Ashish Bavdekar; Anand Pandit; Helga Weirich-Schwaiger; Heiko Witt; Helmut Ellemunter; Johann Deutsch; Helmut Denk; Wilfried Müller; Irmin Sternlieb; M Stuart Tanner; Cisca Wijmenga
The canine copper toxicosis gene MURR1 does not cause non-Wilsonian hepatic copper toxicosis.
Journal of hepatology 2003;38(2):164-8.