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zeger debyser

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Cristina Di Primio; Rik Gijsbers; Valentina Quercioli; Awatef Allouch; Daniele Arosio; Frauke Christ; zeger debyser; Anna Cereseto
Single-cell imaging of HIV-1 provirus (SCIP).
Erik Serrao; Hiroyuki Otake; Frauke Christ; Bikash Debnath; zeger debyser; Yuting Kuang; Nouri Neamati
Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase-Lens Epithelium-Derived Growth Factor/p75 (IN-LEDGF/p75) Interaction.
Gerardo Ramírez-Rodríguez; Harish Babu; Veerle Baekelandt; zeger debyser; Klaus Fabel; Rik Gijsbers; Friederike Klempin; Olga Krylyshkina; Zeina Nicola; Rupert W Overall; Gerd Kempermann
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.

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2013: Cristina Di Primio; Rik Gijsbers; Valentina Quercioli; Awatef Allouch; Daniele Arosio; Frauke Christ; zeger debyser; Anna Cereseto
Single-cell imaging of HIV-1 provirus (SCIP).
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):5636-41.
2013: Erik Serrao; Hiroyuki Otake; Frauke Christ; Bikash Debnath; zeger debyser; Yuting Kuang; Nouri Neamati
Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase-Lens Epithelium-Derived Growth Factor/p75 (IN-LEDGF/p75) Interaction.
Journal of medicinal chemistry 2013;56(6):2311-22.
2013: Gerardo Ramírez-Rodríguez; Harish Babu; Veerle Baekelandt; zeger debyser; Klaus Fabel; Rik Gijsbers; Friederike Klempin; Olga Krylyshkina; Zeina Nicola; Rupert W Overall; Gerd Kempermann
The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013;33(13):5785-96.
2013: Rik Schrijvers; Frauke Christ; Jan De Rijck; zeger debyser; Jonas Demeulemeester; Melanie Gérard; Rik Gijsbers
Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors.
AIDS (London, England) 2013;27(4):539-43.
2013: Tino Wilson Sanchez; Hiroyuki Otake; Frauke Christ; Bikash Debnath; zeger debyser; Nouri Neamati
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
Bioorganic & medicinal chemistry 2013;21(4):957-63.
2013: Frauke Christ; zeger debyser
The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.
Virology 2013;435(1):102-9.
2013: Sofie Vets; Manuel Grez; Christian Brendel; Frederic Bushman; Jan De Rijck; zeger debyser; Rik Gijsbers
Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.
Molecular therapy. Nucleic acids 2013;2():e77.
2013: Binhai Ren; M Anne Swan; Ming Wei; Michelle R Byrne; Edwin Ch'ng; zeger debyser; Prudence N Gatt; Rik Gijsbers; Najah T Nassif; Bronwyn A O'Brien; Ann M Simpson
Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy.
The journal of gene medicine 2013;15(1):28-41.
2012: Teshome L Aboye; Frauke Christ; zeger debyser; Helen Ha; Subhabrata Majumder; Nouri Neamati; Alexander Shekhtman; Julio A Camarero
Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.
Journal of medicinal chemistry 2012;55(23):10729-34.
2012: Christophe M Deroose; Rik Gijsbers; Abdelilah Ibrahimi; Veerle Baekelandt; Jan Balzarini; Guy Bormans; Satish K Chitneni; zeger debyser; Johan Nuyts; Alfons Verbruggen; Peter Vermaelen; Luc Mortelmans
Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Nuclear medicine and biology 2012;39(8):1266-74.
2012: Belete A Desimmie; Ursula Dietrich; Rik Gijsbers; Jelle Hendrix; Michael Humbert; Eveline Lescrinier; Ruth M Ruprecht; Sofie Vets; zeger debyser; Frauke Christ
Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(11):2064-75.
2012: Ross Larue; Nick Shkriabai; Oliver Taltynov; Gregory D Van Duyne; Christiane Wuensch; Frauke Christ; Eric Danhart; zeger debyser; Lei Feng; Mark P Foster; Kushol Gupta; Jacques J Kessl; Mamuka Kvaratskhelia
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
The Journal of biological chemistry 2012;287(41):34044-58.
2012: Stephanie De Houwer; Frauke Christ; Jonas Demeulemeester; Oliver Taltynov; Wannes Thys; Katarina Zmajkovicova; zeger debyser
Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein.
The Journal of biological chemistry 2012;287(41):34059-68.
2012: Shenghui Yu; Linna Zhang; Frauke Christ; zeger debyser; Nouri Neamati; Tino Sanchez; Peng Wang; Shifeng Yan; Guisen Zhao
Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity.
Journal of enzyme inhibition and medicinal chemistry 2012;27(5):628-40.
2012: Rik Schrijvers; zeger debyser
Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF.
Expert opinion on pharmacotherapy 2012;13(13):1969-83.
2012: Véronique Mathieu; Thomas Mohr; Françoise Poirier; Jaan Toelen; Gwendoline Van Goietsenoven; Stefaan W Van Gool; Tina Verschuere; Akeila Bellahcène; Caroline Bouzin; Vincent Castronovo; Elisabeth Martin de Lassalle; Steven De Vleeschouwer; zeger debyser; Robert Kiss; Olivier Feron
Galectin-1 in melanoma biology and related neo-angiogenesis processes.
The Journal of investigative dermatology 2012;132(9):2245-54.
2012: Greetje Vande Velde; Marleen Verhoye; Ruth Vreys; Frederik Maes; Janaki Raman Rangarajan; Annemie Van der Linden; Veerle Baekelandt; zeger debyser; Tom Dresselaers; Caroline Guglielmetti; Uwe Himmelreich
Quantitative evaluation of MRI-based tracking of ferritin-labeled endogenous neural stem cell progeny in rodent brain.
NeuroImage 2012;62(1):367-80.
2012: Frauke Christ; zeger debyser; Jonas Demeulemeester; Belete Ayele Desimmie; Arnaud Marchand; Scott Butler; Patrick Chaltin; Stephen Shaw; Wim Smets; Mike Westby; Chris Pickford
Small-molecule inhibitors of the LEDGF/p75 binding site of integrase block HIV replication and modulate integrase multimerization.
Antimicrobial agents and chemotherapy 2012;56(8):4365-74.
2012: Rik Schrijvers; zeger debyser
Quad's in it for antiretroviral therapy?
Lancet 2012;379(9835):2403-5.
2012: Virginie Suchaud; Enzo Tramontano; zeger debyser; Francesca Esposito; Cédric Lion; Fabrice Bailly; Frauke Christ; Angela Corona; Philippe Cotelle
Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.
Bioorganic & medicinal chemistry letters 2012;22(12):3988-92.
2012: Jonas Demeulemeester; Cristina Tintori; Maurizio Botta; zeger debyser; Frauke Christ
Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors.
Journal of biomolecular screening 2012;17(5):618-28.
2012: Cristina Tintori; Frauke Christ; zeger debyser; Jonas Demeulemeester; Luigi Franchi; Silvio Massa; Maurizio Botta
Discovery of small molecule HIV-1 integrase dimerization inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(9):3109-14.
2012: Sofie Vets; Andreas Volk; Dorothee Von Laer; Jan De Rijck; zeger debyser; Janine Kimpel; Wouter Maes; Rik Schrijvers; Bert Verbinnen; Rik Gijsbers
Lens epithelium-derived growth factor/p75 qualifies as a target for HIV gene therapy in the NSG mouse model.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):908-17.
2012: Sophie Louwette; Juriaan Metz; Chantal Thys; Chris Van Geet; Christine Wittevrongel; Jef Arnout; zeger debyser; Rik Gijsbers; Valery Labarque; Kathleen Freson
Regulator of G-protein signaling 18 controls megakaryopoiesis and the cilia-mediated vertebrate mechanosensory system.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):2125-36.
2012: Anamika Basu; Marino De Leon; zeger debyser; Awa Drame; Rik Gijsbers; Ruben Muñoz; Carlos A Casiano
Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.
The Prostate 2012;72(6):597-611.
2012: Nele Evens; Peter Janssen; Raf Sciot; Koen Van Laere; Caroline Vandeputte; Alfons M Verbruggen; Veerle Baekelandt; Charlotte Coolen; zeger debyser; Guy M Bormans
Preclinical evaluation of [11C]NE40, a type 2 cannabinoid receptor PET tracer.
Nuclear medicine and biology 2012;39(3):389-99.
2012: Lai Sum Leoh; Shannalee R Martinez; Leslimar Rios-Colon; Sandy S Tungteakkhun; Bart van Heertum; Frauke Christ; Marino De Leon; Jan De Rijck; zeger debyser; Valeri Filippov; Maria Filippova; Anamika Basu; Carlos A Casiano
The stress oncoprotein LEDGF/p75 interacts with the methyl CpG binding protein MeCP2 and influences its transcriptional activity.
Molecular cancer research : MCR 2012;10(3):378-91.
2012: Marianne S Carlon; Marina Mori da Cunha; zeger debyser; Uwe Himmelreich; Steffi Mayer; Johan Nuyts; Lourenço Sbragia; Jaan Toelen; Anke Van der Perren; Dragana Vidović; Jan Deprest
A novel surgical approach for intratracheal administration of bioactive agents in a fetal mouse model.
Journal of visualized experiments : JoVE 2012;(68):.
2012: Marijke De Saint-Hubert; zeger debyser; Ellen Devos; Abdelilah Ibrahimi; Luc Mortelmans; Felix M Mottaghy
Bioluminescence imaging of therapy response does not correlate with FDG-PET response in a mouse model of Burkitt lymphoma.
American journal of nuclear medicine and molecular imaging 2012;2(3):353-61.
2012: Rik Schrijvers; Sofie Vets; Nirav Malani; Frederic D Bushman; Jan De Rijck; zeger debyser; Rik Gijsbers
HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.
Retrovirology 2012;9():84.
2012: Erik Serrao; Wannes Thys; Laith Q Al-Mawsawi; Frauke Christ; zeger debyser; Jonas Demeulemeester; Nouri Neamati
A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.
PloS one 2012;7(9):e45177.
2012: Oliver Taltynov; Frauke Christ; Jonas Demeulemeester; Belete Ayele Desimmie; zeger debyser
Cellular cofactors of lentiviral integrase: from target validation to drug discovery.
Molecular biology international 2012;2012():863405.
2012: M Casssano; M Chuah; S Crippa; zeger debyser; R Micheletti; I Barthelemy; E Berardi; S Blot; Jaan Toelen; T Vandendriessche; Maurilio Sampaolesi
Alteration of cardiac progenitor cell potency in GRMD dogs.
Cell transplantation 2012;21(9):1945-67.
2012: Rik Schrijvers; Sofie Vets; Keshet Ronen; Noritaka Adachi; Frederic D Bushman; Frauke Christ; Jan De Rijck; zeger debyser; Jonas Demeulemeester; Rik Gijsbers
LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.
PLoS pathogens 2012;8(3):e1002558.
2011: Rik Gijsbers; Nirav Malani; Karen E Ocwieja; Keshet Ronen; Sofie Vets; Frederic D Bushman; Jan De Rijck; zeger debyser
Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.
The Journal of biological chemistry 2011;286(48):41812-25.
2011: Laura De Luca; zeger debyser; Stefania Ferro; Rosaria Gitto; Francesca Morreale; Frauke Christ; Sara De Grazia; Alba Chimirri
4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.
Antiviral research 2011;92(1):102-7.
2011: Paradise Madlala; Koleka Patience Mlisana; Lise Werner; Cheryl A Winkler; Salim S Abdool-Karim; Ping An; Frauke Christ; zeger debyser; Rik Gijsbers; Anneleen Hombrouck; Thumbi Ndung'u
Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.
AIDS (London, England) 2011;25(14):1711-9.
2011: Nele Evens; Didier M Lambert; Giulio G Muccioli; Koen Van Laere; Caroline Vandeputte; Alfons M Verbruggen; Veerle Baekelandt; zeger debyser; Guy M Bormans
Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging.
Bioorganic & medicinal chemistry 2011;19(15):4499-505.
2011: giovanni maga; Fabrizio Manetti; Stefania Paolucci; Marco Radi; Alberta Samuele; Samantha Zanoli; Elisa Zucca; Fausto Baldanti; Martina Bernardini; Lorenzo Botta; Gianni Casaluce; Jan De Rijck; zeger debyser; José A Esté; Federico Falchi; Anna Garbelli; Emmanuel Gonzalez; Hamid Irannejad; Maurizio Botta
Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.
ChemMedChem 2011;6(8):1371-89.
2011: Melanie Gerard; zeger debyser; Angélique Deleersnijder; Jonas Demeulemeester; Veerle Baekelandt
Unraveling the role of peptidyl-prolyl isomerases in neurodegeneration.
Molecular neurobiology 2011;44(1):13-27.
2011: Melissa McNeely; Angélique Deleersnijder; Melanie Gerard; Jelle Hendrix; Eline Boons; Katrien Busschots; Frauke Christ; zeger debyser
In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.
Journal of molecular biology 2011;410(5):811-30.
2011: Angélique Deleersnijder; Linda Desender; Veerle Baekelandt; Luc BUEE; zeger debyser; Hans Pottel; Anne-Sophie Van Rompuy; Melanie Gerard
Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation.
The Journal of biological chemistry 2011;286(30):26687-701.
2011: Rik Schrijvers; Belete Ayele Desimmie; zeger debyser
Rilpivirine: a step forward in tailored HIV treatment.
Lancet 2011;378(9787):201-3.
2011: Caroline Vandeputte; Alfons Verbruggen; Veerle Baekelandt; Guy Bormans; Barbara Bosier; zeger debyser; Christophe M Deroose; Nele Evens; Rik Gijsbers; Abdelilah Ibrahimi; Peter Janssen; Didier M Lambert; Jaan Toelen; Anke Van der Perren; Koen Van Laere
A PET brain reporter gene system based on type 2 cannabinoid receptors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2011;52(7):1102-9.
2011: Stefania Crippa; Tomaz Curk; zeger debyser; Daniela Galli; Beatriz G Galvez; Rik Gijsbers; Stefan Janssens; Graziella Messina; Flavio Ronzoni; Claudia Altomare; Marco Cassano; Giulio Cossu; Jaan Toelen; Antonio Zaza; Blaz Zupan; Maurilio Sampaolesi
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.
The Journal of cell biology 2011;193(7):1197-212.
2011: G Vande Velde; Ruth Vreys; zeger debyser; Tom Dresselaers; U Himmelreich; A Ibrahimi; O Krylychkina; Frederik Maes; J R Rangarajan; Jaan Toelen; Annemie Van der Linden; Veerle Baekelandt
Evaluation of the specificity and sensitivity of ferritin as an MRI reporter gene in the mouse brain using lentiviral and adeno-associated viral vectors.
Gene therapy 2011;18(6):594-605.
2011: A Van der Perren; Jaan Toelen; M Carlon; Chris Van den Haute; F Coun; B Heeman; V Reumers; Luk Vandenberghe; James M Wilson; zeger debyser; Veerle Baekelandt
Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9.
Gene therapy 2011;18(5):517-27.
2011: Bavo Heeman; Chris Van den Haute; Sarah-Ann Aelvoet; Federica Valsecchi; Richard J Rodenburg; Veerle Reumers; zeger debyser; Geert Callewaert; Werner J H Koopman; Peter H G M Willems; Veerle Baekelandt
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance.
Journal of cell science 2011;124(Pt 7):1115-25.
2011: Muriel Billamboz; Fabrice Bailly; Cédric Lion; Nadia Touati; Hervé Vezin; Christina Calmels; Marie-Line Andréola; Frauke Christ; zeger debyser; Philippe Cotelle
Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.
Journal of medicinal chemistry 2011;54(6):1812-24.
2011: Jelle Hendrix; Rik Gijsbers; Jan De Rijck; Arnout Voet; Jun-ichi Hotta; Melissa McNeely; Johan Hofkens; zeger debyser; Yves Engelborghs
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering.
Nucleic acids research 2011;39(4):1310-25.
2011: Marta Rinaldi; Cristina Tintori; Luigi Franchi; Giulia Vignaroli; Anna Innitzer; Silvio Massa; José A Esté; Encarna Gonzalo; Frauke Christ; zeger debyser; Maurizio Botta
A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors.
ChemMedChem 2011;6(2):343-52.
2011: Laura De Luca; Sara De Grazia; Stefania Ferro; Rosaria Gitto; Frauke Christ; zeger debyser; Alba Chimirri
HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.
European journal of medicinal chemistry 2011;46(2):756-64.
2011: Muriel Billamboz; Fabrice Bailly; Cédric Lion; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Laura De Luca; Alba Chimirri; Philippe Cotelle
2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.
European journal of medicinal chemistry 2011;46(2):535-46.
2011: Wannes Thys; Stéphanie De Houwer; Jonas Demeulemeester; Oliver Taltynov; Renée Vancraenenbroeck; Melanie Gérard; Jan De Rijck; Rik Gijsbers; Frauke Christ; zeger debyser
Interplay between HIV entry and transportin-SR2 dependency.
Retrovirology 2011;8():7.
2010: Marianne Carlon; Jaan Toelen; Anke Van der Perren; Luk Vandenberghe; Veerle Reumers; Lourenço Sbragia; Rik Gijsbers; Veerle Baekelandt; Uwe Himmelreich; James M Wilson; Jan Deprest; zeger debyser
Efficient gene transfer into the mouse lung by fetal intratracheal injection of rAAV2/6.2.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(12):2130-8.
2010: Laura De Luca; Stefania Ferro; Rosaria Gitto; Maria Letizia Barreca; Stefano Agnello; Frauke Christ; zeger debyser; Alba Chimirri
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.
Bioorganic & medicinal chemistry 2010;18(21):7515-21.
2010: Martin Lock; Mauricio Alvira; Luk Vandenberghe; Arabinda Samanta; Jaan Toelen; zeger debyser; James M Wilson
Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale.
Human gene therapy 2010;21(10):1259-71.
2010: Jan De Rijck; Koen Bartholomeeusen; Hugo Ceulemans; zeger debyser; Rik Gijsbers
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region.
Nucleic acids research 2010;38(18):6135-47.
2010: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Sara De Grazia; Frauke Christ; zeger debyser; Alba Chimirri
New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.
Bioorganic & medicinal chemistry 2010;18(15):5510-8.
2010: Cédric Maurin; Cédric Lion; Fabrice Bailly; Nadia Touati; Hervé Vezin; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.
Bioorganic & medicinal chemistry 2010;18(14):5194-201.
2010: Frauke Christ; Arnout Voet; Arnaud Marchand; Stefan Nicolet; Belete Ayele Desimmie; Damien Marchand; Dorothée Bardiot; Nam Joo Van der Veken; Barbara Van Remoortel; Sergei V Strelkov; Marc De Maeyer; Patrick Chaltin; zeger debyser
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.
Nature chemical biology 2010;6(6):442-8.
2010: Christophe Dubois; Xiaoshun Liu; Piet Claus; Glenn Marsboom; Peter Pokreisz; Sara Vandenwijngaert; Hélène Dépelteau; Witold Streb; Lertlak Chaothawee; Frederik Maes; Olivier Gheysens; zeger debyser; Hilde Gillijns; Marijke Pellens; Thierry Vandendriessche; Marinee Chuah; Desiré Collen; Erik Verbeken; Ann Belmans; Frans Van de Werf; Jan Bogaert; Stefan Janssens
Differential effects of progenitor cell populations on left ventricular remodeling and myocardial neovascularization after myocardial infarction.
Journal of the American College of Cardiology 2010;55(20):2232-43.
2010: Nadja Van Camp; Ruth Vreys; Koen Van Laere; Erwin Lauwers; Dirk Beque; Marleen Verhoye; Cindy Casteels; Alfons Verbruggen; zeger debyser; Luc Mortelmans; Jan Sijbers; Johan Nuyts; Veerle Baekelandt; Annemie Van der Linden
Morphologic and functional changes in the unilateral 6-hydroxydopamine lesion rat model for Parkinson's disease discerned with microSPECT and quantitative MRI.
Magma (New York, N.Y.) 2010;23(2):65-75.
2010: Rik Gijsbers; Keshet Ronen; Sofie Vets; Nirav Malani; Jan De Rijck; Melissa McNeely; Frederic D Bushman; zeger debyser
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.
Molecular therapy : the journal of the American Society of Gene Therapy 2010;18(3):552-60.
2010: Melanie Gerard; Angélique Deleersnijder; Veronique Daniëls; Sarah Schreurs; Sebastian Munck; Veerle Reumers; Hans Pottel; Yves Engelborghs; Chris Van den Haute; Jean-Marc Taymans; zeger debyser; Veerle Baekelandt
Inhibition of FK506 binding proteins reduces alpha-synuclein aggregation and Parkinson's disease-like pathology.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(7):2454-63.
2010: Jan A Deprest; Roland Devlieger; Kasemsri Srisupundit; Veronika Beck; Inga Sandaite; Silvia Rusconi; Filip Claus; Gunnar Naulaers; Marc Van de Velde; Paul Brady; koenraad devriendt; Joris Vermeesch; Jaan Toelen; Marianne Carlon; zeger debyser; Luc De Catte; Liesbeth Lewi
Fetal surgery is a clinical reality.
Seminars in fetal & neonatal medicine 2010;15(1):58-67.
2010: zeger debyser; Frauke Christ
On the cell biology of HIV integration from basic research to development of novel antiviral drugs.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2010;72(5-6):219-37.
2010: Evy Lobbestael; Veerle Reumers; Abdelilah Ibrahimi; Kirsten Paesen; Irina Thiry; Rik Gijsbers; Chris Van den Haute; zeger debyser; Veerle Baekelandt; Jean-Marc Taymans
Immunohistochemical detection of transgene expression in the brain using small epitope tags.
BMC biotechnology 2010;10():16.
2009: Katia Pauwels; Rik Gijsbers; Jaan Toelen; Axel Schambach; Karen Willard-Gallo; Céline Verheust; zeger debyser; Philippe Herman
State-of-the-art lentiviral vectors for research use: risk assessment and biosafety recommendations.
Current gene therapy 2009;9(6):459-74.
2009: Luk Vandenberghe; E Breous; H-J Nam; Guangping Gao; R Xiao; A Sandhu; Julie Johnston; zeger debyser; Mavis Agbandje-McKenna; James M Wilson
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.
Gene therapy 2009;16(12):1416-28.
2009: Arnout Voet; Marc De Maeyer; zeger debyser; Frauke Christ
In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.
Future medicinal chemistry 2009;1(7):1259-74.
2009: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Frauke Christ; Nunzio Iraci; Rosaria Gitto; Anna Maria Monforte; zeger debyser; Alba Chimirri
Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.
ChemMedChem 2009;4(8):1311-6.
2009: Abdelilah Ibrahimi; Greetje Vande Velde; Veerle Reumers; Jaan Toelen; Irina Thiry; Caroline Vandeputte; Sofie Vets; Christophe M Deroose; Guy Bormans; Veerle Baekelandt; zeger debyser; Rik Gijsbers
Highly efficient multicistronic lentiviral vectors with peptide 2A sequences.
Human gene therapy 2009;20(8):845-60.
2009: Sofie Celen; Jan Cleynhens; Christophe Deroose; Tjibbe de Groot; Abdelilah Ibrahimi; Rik Gijsbers; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
Synthesis and biological evaluation of (11)C-labeled beta-galactosyl triazoles as potential PET tracers for in vivo LacZ reporter gene imaging.
Bioorganic & medicinal chemistry 2009;17(14):5117-25.
2009: Suvi Rajamaki; Anna Innitzer; Chiara Falciani; Cristina Tintori; Frauke Christ; Myriam Witvrouw; zeger debyser; Silvio Massa; Maurizio Botta
Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(13):3615-8.
2009: Christophe M Deroose; Veerle Reumers; zeger debyser; Veerle Baekelandt
Seeing genes at work in the living brain with non-invasive molecular imaging.
Current gene therapy 2009;9(3):212-38.
2009: Koen Bartholomeeusen; Frauke Christ; Jelle Hendrix; Jean-Christophe Rain; Stéphane Emiliani; Richard Benarous; zeger debyser; Rik Gijsbers; Jan De Rijck
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.
The Journal of biological chemistry 2009;284(17):11467-77.
2009: Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; Sara De Grazia; Frauke Christ; Myriam Witvrouw; zeger debyser; Alba Chimirri
Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.
Journal of medicinal chemistry 2009;52(2):569-73.
2009: Katrien Busschots; Jan De Rijck; Frauke Christ; zeger debyser
In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.
Molecular bioSystems 2009;5(1):21-31.
2009: Wouter Maes; Christophe M Deroose; V Reumers; Olga Krylyshkina; Rik Gijsbers; Veerle Baekelandt; Jan L Ceuppens; zeger debyser; Stefaan W Van Gool
In vivo bioluminescence imaging in an experimental mouse model for dendritic cell based immunotherapy against malignant glioma.
Journal of neuro-oncology 2009;91(2):127-39.
2008: Muriel Billamboz; Fabrice Bailly; Maria Letizia Barreca; Laura De Luca; Jean-François Mouscadet; Christina Calmels; Marie-Line Andréola; Myriam Witvrouw; Frauke Christ; zeger debyser; Philippe Cotelle
Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.
Journal of medicinal chemistry 2008;51(24):7717-30.
2008: Melissa McNeely; Frauke Christ; Wannes Thys; zeger debyser
Targeting the HIV integration process in antiviral therapy.
Journal of HIV therapy 2008;13(4):83-92.
2008: Warner Greene; zeger debyser; Yasuhiro Ikeda; Eric O Freed; Edward Stephens; Wes Yonemoto; Robert W Buckheit; José A Esté; Tomas Cihlar
Novel targets for HIV therapy.
Antiviral research 2008;80(3):251-65.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.
European journal of medicinal chemistry 2008;43(10):2268-71.
2008: Veerle Reumers; Christophe M Deroose; Olga Krylyshkina; Johan Nuyts; Martine Geraerts; Luc Mortelmans; Rik Gijsbers; Chris Van den Haute; zeger debyser; Veerle Baekelandt
Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging.
Stem cells (Dayton, Ohio) 2008;26(9):2382-90.
2008: Ellen Gielen; Nick Smisdom; Ben De Clercq; Martin VandeVen; Rik Gijsbers; zeger debyser; Jean-Michel Rigo; Johan Hofkens; Yves Engelborghs; Marcel Ameloot
Diffusion of myelin oligodendrocyte glycoprotein in living OLN-93 cells investigated by raster-scanning image correlation spectroscopy (RICS).
Journal of fluorescence 2008;18(5):813-9.
2008: Serena Pasquini; Claudia Mugnaini; Cristina Tintori; Maurizio Botta; Alejandro Trejos; Riina K Arvela; Mats Larhed; Myriam Witvrouw; Martine Michiels; Frauke Christ; zeger debyser; Federico Corelli
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.
Journal of medicinal chemistry 2008;51(16):5125-9.
2008: Frauke Christ; Wannes Thys; Jan De Rijck; Rik Gijsbers; Alberto albanese; Daniele Arosio; Stéphane Emiliani; Jean-Christophe Rain; Richard Benarous; Anna Cereseto; zeger debyser
Transportin-SR2 imports HIV into the nucleus.
Current biology : CB 2008;18(16):1192-202.
2008: Clémence Queffélec; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; Sean Hayes; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Synthesis and antiviral properties of some polyphenols related to Salvia genus.
Bioorganic & medicinal chemistry letters 2008;18(16):4736-40.
2008: Terry A Brown-Bryan; Lai S Leoh; Vidya Ganapathy; Fabio J Pacheco; Melanie Mediavilla-Varela; Maria Filippova; Thomas A Linkhart; Rik Gijsbers; zeger debyser; Carlos A Casiano
Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.
Molecular cancer research : MCR 2008;6(8):1293-307.
2008: Anneleen Hombrouck; Barbara Van Remoortel; Martine Michiels; Wim Noppe; Frauke Christ; Anders Eneroth; Britt Louise Sahlberg; Kurt Benkestock; Lotta Vrang; Nils Gunnar Johansson; Maria Letizia Barreca; Laura De Luca; Stefania Ferro; Alba Chimirri; zeger debyser; Myriam Witvrouw
Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors.
Antimicrobial agents and chemotherapy 2008;52(8):2861-9.
2008: Laith Q Al-Mawsawi; Anneleen Hombrouck; Raveendra Dayam; zeger debyser; Nouri Neamati
Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity.
Virology 2008;377(2):355-63.
2008: Melanie Gerard; zeger debyser; Linda Desender; Johan Baert; Inger Brandt; Veerle Baekelandt; Yves Engelborghs
FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.
Journal of neurochemistry 2008;106(1):121-33.
2008: Anneleen Hombrouck; Arnout Voet; Barbara Van Remoortel; Christel Desadeleer; Marc De Maeyer; zeger debyser; Myriam Witvrouw
Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.
Antimicrobial agents and chemotherapy 2008;52(6):2069-78.
2008: Satish K Chitneni; Kim Serdons; Nele Evens; Humphrey Fonge; Sofie Celen; Christophe M Deroose; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction.
Journal of chromatography. A 2008;1189(1-2):323-31.
2008: Laura De Luca; Maria Letizia Barreca; Stefania Ferro; Nunzio Iraci; Martine Michiels; Frauke Christ; zeger debyser; Myriam Witvrouw; Alba Chimirri
A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.
Bioorganic & medicinal chemistry letters 2008;18(9):2891-5.
2008: Laith Q Al-Mawsawi; Frauke Christ; Raveendra Dayam; zeger debyser; Nouri Neamati
Inhibitory profile of a LEDGF/p75 peptide against HIV-1 integrase: insight into integrase-DNA complex formation and catalysis.
FEBS letters 2008;582(10):1425-30.
2008: Mélanie Dubois; Fabrice Bailly; Gladys Mbemba; Jean-François Mouscadet; zeger debyser; Myriam Witvrouw; Philippe Cotelle
Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.
Journal of medicinal chemistry 2008;51(8):2575-9.
2008: Raveendra Dayam; Laith Q Al-Mawsawi; Zahrah Zawahir; Myriam Witvrouw; zeger debyser; Nouri Neamati
Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.
Journal of medicinal chemistry 2008;51(5):1136-44.
2008: Sofie Celen; Christophe M Deroose; Tjibbe de Groot; Satish K Chitneni; Rik Gijsbers; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.
Bioconjugate chemistry 2008;19(2):441-9.
2007: Satish K Chitneni; Christophe M Deroose; Jan Balzarini; Rik Gijsbers; Sofie Celen; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.
Journal of medicinal chemistry 2007;50(26):6627-37.
2007: Laith Q Al-Mawsawi; Raveendra Dayam; Laleh Taheri; Myriam Witvrouw; zeger debyser; Nouri Neamati
Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(23):6472-5.
2007: Claudia Mugnaini; Suvi Rajamaki; Cristina Tintori; Federico Corelli; Silvio Massa; Myriam Witvrouw; zeger debyser; veljko veljkovic; Maurizio Botta
Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.
Bioorganic & medicinal chemistry letters 2007;17(19):5370-3.
2007: Koen Bartholomeeusen; Jan De Rijck; Katrien Busschots; Linda Desender; Rik Gijsbers; Stéphane Emiliani; Richard Benarous; zeger debyser; Frauke Christ
Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.
Journal of molecular biology 2007;372(2):407-21.
2007: Golo Kronenberg; Li-Ping Wang; Martine Geraerts; Harish Babu; Michael Synowitz; Paloma Vicens; Gudrun Lutsch; Rainer Glass; Masahiro Yamaguchi; Veerle Baekelandt; zeger debyser; Helmut Kettenmann; Gerd Kempermann
Local origin and activity-dependent generation of nestin-expressing protoplasmic astrocytes in CA1.
Brain structure & function 2007;212(1):19-35.
2007: Cristina Tintori; Fabrizio Manetti; Nevena Veljkovic; Vladimir Perovic; Jo Vercammen; Sean Hayes; Silvio Massa; Myriam Witvrouw; zeger debyser; veljko veljkovic; Maurizio Botta
Novel virtual screening protocol based on the combined use of molecular modeling and electron-ion interaction potential techniques to design HIV-1 integrase inhibitors.
Journal of chemical information and modeling 2007;47(4):1536-44.
2007: Satish K Chitneni; Christophe M Deroose; Humphrey Fonge; Rik Gijsbers; Natalia Dyubankova; Jan Balzarini; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging.
Bioorganic & medicinal chemistry letters 2007;17(12):3458-62.
2007: Stefania Ferro; Maria Letizia Barreca; Laura De Luca; Angela Rao; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, beta-diketo acid analogs as HIV-1 integrase inhibitors.
Archiv der Pharmazie 2007;340(6):292-8.
2007: Anneleen Hombrouck; Anke Hantson; Barbara Van Remoortel; Martine Michiels; Jo Vercammen; D Rhodes; V Tetz; Yves Engelborghs; Frauke Christ; zeger debyser; Myriam Witvrouw
Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.
The Journal of antimicrobial chemotherapy 2007;59(6):1084-95.
2007: Jan De Rijck; Linos Vandekerckhove; Frauke Christ; zeger debyser
Lentiviral nuclear import: a complex interplay between virus and host.
BioEssays : news and reviews in molecular, cellular and developmental biology 2007;29(5):441-51.
2007: Jaan Toelen; Christophe M Deroose; Rik Gijsbers; Veerle Reumers; Lourenço N Sbragia; Sofie Vets; Satish K Chitneni; Guy Bormans; Luc Mortelmans; Jan A Deprest; zeger debyser
Fetal gene transfer with lentiviral vectors: long-term in vivo follow-up evaluation in a rat model.
American journal of obstetrics and gynecology 2007;196(4):352.e1-6.
2007: Satish K Chitneni; Christophe M Deroose; Jan Balzarini; Rik Gijsbers; Sofie Celen; Tjibbe de Groot; zeger debyser; Luc Mortelmans; Alfons Verbruggen; Guy Bormans
Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.
Journal of medicinal chemistry 2007;50(5):1041-9.
2007: Anneleen Hombrouck; Jan De Rijck; Jelle Hendrix; Linos Vandekerckhove; Arnout Voet; Marc De Maeyer; Myriam Witvrouw; Yves Engelborghs; Frauke Christ; Rik Gijsbers; zeger debyser
Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.
PLoS pathogens 2007;3(3):e47.
2007: Jean-Marc Taymans; Luk Vandenberghe; Chris Van den Haute; Irina Thiry; Christophe M Deroose; Luc Mortelmans; James M Wilson; zeger debyser; Veerle Baekelandt
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.
Human gene therapy 2007;18(3):195-206.
2007: veljko veljkovic; Jean-François Mouscadet; Nevena Veljkovic; Sanja Glisic; zeger debyser
Simple criterion for selection of flavonoid compounds with anti-HIV activity.
Bioorganic & medicinal chemistry letters 2007;17(5):1226-32.
2007: Katrien Busschots; Arnout Voet; Marc De Maeyer; Jean-Christophe Rain; Stéphane Emiliani; Richard Benarous; Linda Desender; zeger debyser; Frauke Christ
Identification of the LEDGF/p75 binding site in HIV-1 integrase.
Journal of molecular biology 2007;365(5):1480-92.
2007: Martine Geraerts; Olga Krylyshkina; zeger debyser; Veerle Baekelandt
Concise review: therapeutic strategies for Parkinson disease based on the modulation of adult neurogenesis.
Stem cells (Dayton, Ohio) 2007;25(2):263-70.
2007: Erwin Lauwers; Dirk Bequé; Koen Van Laere; Johan Nuyts; Guy Bormans; Luc Mortelmans; Cindy Casteels; Linda Vercammen; Olivier Bockstael; Bart Nuttin; zeger debyser; Veerle Baekelandt
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression.
Neurobiology of aging 2007;28(2):248-57.
2006: Jan De Rijck; Linos Vandekerckhove; Rik Gijsbers; Anneleen Hombrouck; Jelle Hendrix; Jo Vercammen; Yves Engelborghs; Frauke Christ; zeger debyser
Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication.
Journal of virology 2006;80(23):11498-509.
2006: Linda Vercammen; Anke Van der Perren; Elisabetta Vaudano; Rik Gijsbers; zeger debyser; Chris Van den Haute; Veerle Baekelandt
Parkin protects against neurotoxicity in the 6-hydroxydopamine rat model for Parkinson's disease.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):716-23.
2006: Jan De Rijck; zeger debyser
The central DNA flap of the human immunodeficiency virus type 1 is important for viral replication.
Biochemical and biophysical research communications 2006;349(3):1100-10.
2006: Christophe M Deroose; Veerle Reumers; Rik Gijsbers; Guy Bormans; zeger debyser; Luc Mortelmans; Veerle Baekelandt
Noninvasive monitoring of long-term lentiviral vector-mediated gene expression in rodent brain with bioluminescence imaging.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(3):423-31.
2006: Martine Geraerts; Kristel Eggermont; Pilar Hernandez-Acosta; Jose Manuel Garcia-Verdugo; Veerle Baekelandt; zeger debyser
Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo.
Human gene therapy 2006;17(6):635-50.
2006: Melanie Gerard; zeger debyser; Linda Desender; Philipp J Kahle; Johan Baert; Veerle Baekelandt; Yves Engelborghs
The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(3):524-6.
2006: Linos Vandekerckhove; Frauke Christ; Bénédicte Van Maele; Jan De Rijck; Rik Gijsbers; Chris Van den Haute; Myriam Witvrouw; zeger debyser
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.
Journal of virology 2006;80(4):1886-96.
2006: Bénédicte Van Maele; Katrien Busschots; Linos Vandekerckhove; Frauke Christ; zeger debyser
Cellular co-factors of HIV-1 integration.
Trends in biochemical sciences 2006;31(2):98-105.
2006: Martine Geraerts; Sofie Willems; Veerle Baekelandt; zeger debyser; Rik Gijsbers
Comparison of lentiviral vector titration methods.
BMC biotechnology 2006;6():34.
2005: Maria Letizia Barreca; Stefania Ferro; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; zeger debyser; Myriam Witvrouw; Alba Chimirri
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.
Journal of medicinal chemistry 2005;48(22):7084-8.
2005: Martine Geraerts; Martine Michiels; Veerle Baekelandt; zeger debyser; Rik Gijsbers
Upscaling of lentiviral vector production by tangential flow filtration.
The journal of gene medicine 2005;7(10):1299-310.
2005: Stéphane Emiliani; Aurélie Mousnier; Katrien Busschots; Marlène Maroun; Bénédicte Van Maele; Denis Tempé; Linos Vandekerckhove; Fanny Moisant; Lilia Ben-Slama; Myriam Witvrouw; Frauke Christ; Jean-Christophe Rain; Catherine Dargemont; zeger debyser; Richard Benarous
Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.
The Journal of biological chemistry 2005;280(27):25517-23.
2005: Goedele Maertens; Jo Vercammen; zeger debyser; Yves Engelborghs
Measuring protein-protein interactions inside living cells using single color fluorescence correlation spectroscopy. Application to human immunodeficiency virus type 1 integrase and LEDGF/p75.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(8):1039-41.
2005: Katrien Busschots; Jo Vercammen; Stéphane Emiliani; Richard Benarous; Yves Engelborghs; Frauke Christ; zeger debyser
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.
The Journal of biological chemistry 2005;280(18):17841-7.
2005: Jan De Rijck; Bénédicte Van Maele; zeger debyser
Positional effects of the central DNA flap in HIV-1-derived lentiviral vectors.
Biochemical and biophysical research communications 2005;328(4):987-94.
2005: Bénédicte Van Maele; Leen Van Eylen; Wim Pluymers; zeger debyser
Evaluation of the activity of HIV-1 integrase over-expressed in eukaryotic cells.
Biochemical and biophysical research communications 2005;327(1):261-7.
2005: Anke Hantson; Valery Fikkert; Barbara Van Remoortel; Christophe Pannecouque; Peter Cherepanov; Barry Matthews; George Holan; Erik De Clercq; Anne-Mieke Vandamme; zeger debyser; Myriam Witvrouw
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy 2005;16(4):253-66.
2005: Johan van Griensven; Erik De Clercq; zeger debyser
Hematopoietic stem cell-based gene therapy against HIV infection: promises and caveats.
AIDS reviews 2005;7(1):44-55.
2005: Bénédicte Van Maele; zeger debyser
HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.
AIDS reviews 2005;7(1):26-43.
2004: Valery Fikkert; Anneleen Hombrouck; Barbara Van Remoortel; Marc De Maeyer; Christophe Pannecouque; Erik De Clercq; zeger debyser; Myriam Witvrouw
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.
AIDS (London, England) 2004;18(15):2019-28.
2004: Goedele Maertens; Peter Cherepanov; zeger debyser; Yves Engelborghs; Alan Engelman
Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75.
The Journal of biological chemistry 2004;279(32):33421-9.
2004: Myriam Witvrouw; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Yves Engelborghs; Erik De Clercq; Christophe Pannecouque; zeger debyser
Novel inhibitors of HIV-1 integration.
Current drug metabolism 2004;5(4):291-304.
2004: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Cristina Gurnari; Pietro Monforte; Erik De Clercq; Bénédicte Van Maele; zeger debyser; Myriam Witvrouw; James M Briggs; Alba Chimirri
Efficient 3D database screening for novel HIV-1 IN inhibitors.
Journal of chemical information and computer sciences 2004;44(4):1450-5.
2004: Johan van Griensven; Xiaojing Zhan; Bénédicte Van Maele; Wim Pluymers; Martine Michiels; Erik De Clercq; Peter Cherepanov; zeger debyser
Expression of HIV-1 integrase in CEM cells inhibits HIV-1 replication.
The journal of gene medicine 2004;6(3):268-77.
2003: Chris Van den Haute; Kristel Eggermont; Bart Nuttin; zeger debyser; Veerle Baekelandt
Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain.
Human gene therapy 2003;14(18):1799-807.
2003: zeger debyser
Biosafety of lentiviral vectors.
Current gene therapy 2003;3(6):517-25.
2003: zeger debyser
A short course on virology / vectorology / gene therapy.
Current gene therapy 2003;3(6):495-9.
2003: Valery Fikkert; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Barbara Van Remoortel; Martine Michiels; Cristina Gurnari; Christophe Pannecouque; Marc De Maeyer; Yves Engelborghs; Erik De Clercq; zeger debyser; Myriam Witvrouw
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Journal of virology 2003;77(21):11459-70.
2003: Veerle Baekelandt; Kristel Eggermont; Martine Michiels; Bart Nuttin; zeger debyser
Optimized lentiviral vector production and purification procedure prevents immune response after transduction of mouse brain.
Gene therapy 2003;10(23):1933-40.
2003: Goedele Maertens; Peter Cherepanov; Wim Pluymers; Katrien Busschots; Erik De Clercq; zeger debyser; Yves Engelborghs
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.
The Journal of biological chemistry 2003;278(35):33528-39.
2003: Erwin Lauwers; zeger debyser; Jo Van Dorpe; Bart De Strooper; Bart Nuttin; Veerle Baekelandt
Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein.
Brain pathology (Zurich, Switzerland) 2003;13(3):364-72.
2003: Irene M Lagoja; Christophe Pannecouque; Arthur Van Aerschot; Myriam Witvrouw; zeger debyser; Jan Balzarini; Piet Herdewijn; Erik De Clercq
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Journal of medicinal chemistry 2003;46(8):1546-53.
2003: Bénédicte Van Maele; Jan De Rijck; Erik De Clercq; zeger debyser
Impact of the central polypurine tract on the kinetics of human immunodeficiency virus type 1 vector transduction.
Journal of virology 2003;77(8):4685-94.
2003: Mika Okamoto; xin wang; zeger debyser; Erik De Clercq; Masanori Baba
Establishment of an in vitro assay system mimicking human immunodeficiency virus type 1-induced neural cell death and evaluation of inhibitors thereof.
Journal of virological methods 2003;108(2):195-203.
2003: Peter Cherepanov; Goedele Maertens; Paul Proost; Bart Devreese; Jozef Van Beeumen; Yves Engelborghs; Erik De Clercq; zeger debyser
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells.
The Journal of biological chemistry 2003;278(1):372-81.
2003: M Witvrouw; zeger debyser
The integrase of the human immunodeficiency virus as a novel target for the antiviral therapy of AIDS.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2003;65(5):325-34.
2002: Valery Fikkert; Peter Cherepanov; Kristel Van Laethem; Anke Hantson; Barbara Van Remoortel; Christophe Pannecouque; Erik De Clercq; zeger debyser; Anne-Mieke Vandamme; Myriam Witvrouw
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Antimicrobial agents and chemotherapy 2002;46(12):3954-62.
2002: Jo Vercammen; Goedele Maertens; Melanie Gerard; Erik De Clercq; zeger debyser; Yves Engelborghs
DNA-induced polymerization of HIV-1 integrase analyzed with fluorescence fluctuation spectroscopy.
The Journal of biological chemistry 2002;277(41):38045-52.
2002: Wim Pluymers; Godwin C G Pais; Bénédicte Van Maele; Christophe Pannecouque; Valery Fikkert; Terrence R Burke; Erik De Clercq; Myriam Witvrouw; Nouri Neamati; zeger debyser
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Antimicrobial agents and chemotherapy 2002;46(10):3292-7.
2002: Christophe Pannecouque; Wim Pluymers; Bénédicte Van Maele; Victor Tetz; Peter Cherepanov; Erik De Clercq; Myriam Witvrouw; zeger debyser
New class of HIV integrase inhibitors that block viral replication in cell culture.
Current biology : CB 2002;12(14):1169-77.
2002: Veerle Baekelandt; Anje Claeys; Kristel Eggermont; Erwin Lauwers; Bart De Strooper; Bart Nuttin; zeger debyser
Characterization of lentiviral vector-mediated gene transfer in adult mouse brain.
Human gene therapy 2002;13(7):841-53.
2002: zeger debyser; Peter Cherepanov; Bénédicte Van Maele; Erik De Clercq; Myriam Witvrouw
In search of authentic inhibitors of HIV-1 integration.
Antiviral chemistry & chemotherapy 2002;13(1):1-15.
2001: Wim Pluymers; Erik De Clercq; zeger debyser
HIV-1 integration as a target for antiretroviral therapy: a review.
Current drug targets. Infectious disorders 2001;1(2):133-49.
2001: zeger debyser; Peter Cherepanov; Wim Pluymers; Erik De Clercq
Assays for the evaluation of HIV-1 integrase inhibitors.
Methods in molecular biology (Clifton, N.J.) 2001;160():139-55.
2000: Veerle Baekelandt; Anje Claeys; Peter Cherepanov; Erik De Clercq; Bart De Strooper; Bart Nuttin; zeger debyser
DNA-Dependent protein kinase is not required for efficient lentivirus integration.
Journal of virology 2000;74(23):11278-85.
2000: Myriam Witvrouw; Valery Fikkert; Wim Pluymers; Barry Matthews; K Mardel; Dominique Schols; J Raff; zeger debyser; Erik De Clercq; George Holan; Christophe Pannecouque
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Molecular pharmacology 2000;58(5):1100-8.
2000: Veerle Baekelandt; Bart De Strooper; Bart Nuttin; zeger debyser
Gene therapeutic strategies for neurodegenerative diseases.
Current opinion in molecular therapeutics 2000;2(5):540-54.
2000: Wim Pluymers; Nouri Neamati; Christophe Pannecouque; Valery Fikkert; C Marchand; Terrence R Burke; Y Pommier; Dominique Schols; Erik De Clercq; zeger debyser; Myriam Witvrouw
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Peter Cherepanov; Wim Pluymers; Anje Claeys; Paul Proost; Erik De Clercq; zeger debyser
High-level expression of active HIV-1 integrase from a synthetic gene in human cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1389-99.
1999: Wim Pluymers; Peter Cherepanov; Dominique Schols; Erik De Clercq; zeger debyser
Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein.
Virology 1999;258(2):327-32.
1999: Peter Cherepanov; D Surratt; Jaan Toelen; Wim Pluymers; Jack D Griffith; Erik De Clercq; zeger debyser
Activity of recombinant HIV-1 integrase on mini-HIV DNA.
Nucleic acids research 1999;27(10):2202-10.
1999: Anne-Mieke Vandamme; Kristel Van Laethem; Jean-Claude Schmit; Eric Van Wijngaerden; M Reynders; zeger debyser; Myriam Witvrouw; Marc Van Ranst; Erik De Clercq; Jan Desmyter
Long-term stability of human immunodeficiency virus viral load and infectivity in whole blood.
European journal of clinical investigation 1999;29(5):445-52.
1999: Z Lin; Nouri Neamati; Hong Zhao; Y Kiryu; Jim A Turpin; Claudia Aberham; Klaus Strebel; Kurt W Kohn; M Witvrouw; C Pannecouque; zeger debyser; E De Clercq; William G Rice; Yves Pommier; Terrence R Burke
Chicoric acid analogues as HIV-1 integrase inhibitors.
Journal of medicinal chemistry 1999;42(8):1401-14.
1999: Robert Oelrichs; Anne-Mieke Vandamme; K Van Laethem; zeger debyser; Francine E McCutchan; Nicholas J Deacon
Full-length genomic sequence of an HIV type 1 subtype G from Kinshasa.
AIDS research and human retroviruses 1999;15(6):585-9.
1998: zeger debyser; Eric Van Wijngaerden; Kristel Van Laethem; Kurt Beuselinck; M Reynders; Erik De Clercq; Jan Desmyter; Anne-Mieke Vandamme
Failure to quantify viral load with two of the three commercial methods in a pregnant woman harboring an HIV type 1 subtype G strain.
AIDS research and human retroviruses 1998;14(5):453-9.
1998: K Park; zeger debyser; Stanley Tabor; Charles C Richardson; Jack D Griffith
Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins.
The Journal of biological chemistry 1998;273(9):5260-70.
1998: José A Esté; C Cabrera; Dominique Schols; Peter Cherepanov; A Gutierrez; Myriam Witvrouw; Christophe Pannecouque; zeger debyser; RF Rando; B Clotet; Jan Desmyter; E De Clercq
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Molecular pharmacology 1998;53(2):340-5.
1997: Peter Cherepanov; José A Esté; RF Rando; JO Ojwang; Gunter Reekmans; R Steinfeld; Guido David; Erik De Clercq; zeger debyser
Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.
Molecular pharmacology 1997;52(5):771-80.
1997: zeger debyser; M Reynders; Patrick Goubau; J Desmyter
Comparative evaluation of three ELISA techniques and an indirect immunofluorescence assay for the serological diagnosis of Epstein-Barr virus infection.
Clinical and diagnostic virology 1997;8(1):71-81.
1997: Myriam Witvrouw; Jan Balzarini; Christophe Pannecouque; S Jhaumeer-Laulloo; José A Esté; Dominique Schols; Peter Cherepanov; Jean-Claude Schmit; zeger debyser; Anne-Mieke Vandamme; Jan Desmyter; S R Ramadas; Erik De Clercq
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1997;41(2):262-8.
1996: H Jonckheere; K De Vreese; zeger debyser; J Vandekerckhove; Jan Balzarini; Jan Desmyter; E De Clercq; Jozef Anne
A two plasmid co-expression system in Escherichia coli for the production of virion-like reverse transcriptase of the human immunodeficiency virus type 1.
Journal of virological methods 1996;61(1-2):113-25.
1996: zeger debyser; E De Clercq
Chemical crosslinking of the subunits of HIV-1 reverse transcriptase.
Protein science : a publication of the Protein Society 1996;5(2):278-86.
1995: Halldor Thormar; Jan Balzarini; zeger debyser; Myriam Witvrouw; Jan Desmyter; E De Clercq
Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.
Antiviral research 1995;27(1-2):49-57.
1995: zeger debyser
DNA substrates for studying replication mechanisms: synthetic replication forks.
Methods in enzymology 1995;262():457-66.
1994: Rudi Pauwels; Koen Andries; zeger debyser; M J Kukla; Dominique Schols; H J Breslin; R Woestenborghs; Jan Desmyter; M A Janssen; E De Clercq
New tetrahydroimidazo[4,5,1-jk][1,4]-benzodiazepin-2(1H)-one and -thione derivatives are potent inhibitors of human immunodeficiency virus type 1 replication and are synergistic with 2',3'-dideoxynucleoside analogs.
Antimicrobial agents and chemotherapy 1994;38(12):2863-70.
1994: zeger debyser; Stanley Tabor; Charles C Richardson
Coordination of leading and lagging strand DNA synthesis at the replication fork of bacteriophage T7.
Cell 1994;77(1):157-66.
1994: E De Clercq; N Yamamoto; Rudi Pauwels; Jan Balzarini; Myriam Witvrouw; K De Vreese; zeger debyser; B Rosenwirth; Peter Peichl; R Datema
Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.
Antimicrobial agents and chemotherapy 1994;38(4):668-74.
1994: Anne-Mieke Vandamme; zeger debyser; Rudi Pauwels; K De Vreese; P Goubau; M Youle; B Gazzard; P A Stoffels; G F Cauwenbergh; J Anne
Characterization of HIV-1 strains isolated from patients treated with TIBO R82913.
AIDS research and human retroviruses 1994;10(1):39-46.
1993: Halldor Thormar; Jan Balzarini; A Holy; J Jindrich; I Rosenberg; zeger debyser; Jan Desmyter; E De Clercq
Inhibition of visna virus replication by 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogs.
Antimicrobial agents and chemotherapy 1993;37(12):2540-4.
1993: zeger debyser; K De Vreese; P P Knops-Gerrits; Veerle Baekelandt; Rama Bhikhabhai; B Strandberg; Rudi Pauwels; Jozef Anne; Jan Desmyter; E De Clercq
Kinetics of different human immunodeficiency virus type 1 reverse transcriptases resistant to human immunodeficiency virus type 1-specific reverse transcriptase inhibitors.
Molecular pharmacology 1993;43(4):521-6.
1993: Rudi Pauwels; Koen Andries; zeger debyser; P Van Daele; Dominique Schols; P Stoffels; K De Vreese; R Woestenborghs; Anne-Mieke Vandamme; C G Janssen
Potent and highly selective human immunodeficiency virus type 1 (HIV-1) inhibition by a series of alpha-anilinophenylacetamide derivatives targeted at HIV-1 reverse transcriptase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1711-5.
1992: N Yamamoto; Dominique Schols; E De Clercq; zeger debyser; Rudi Pauwels; Jan Balzarini; H Nakashima; M Baba; M Hosoya; Robert Snoeck
Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.
Molecular pharmacology 1992;42(6):1109-17.
1992: zeger debyser; K De Vreese; Rudi Pauwels; N Yamamoto; Jozef Anne; E De Clercq; Jan Desmyter
Differential inhibitory effects of TIBO derivatives on different strains of simian immunodeficiency virus.
The Journal of general virology 1992;73 ( Pt 7)():1799-804.
1992: E De Clercq; N Yamamoto; Rudi Pauwels; M Baba; Dominique Schols; H Nakashima; Jan Balzarini; zeger debyser; B A Murrer; D Schwartz
Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(12):5286-90.
1992: zeger debyser; Anne-Mieke Vandamme; Rudi Pauwels; M Baba; Jan Desmyter; E De Clercq
Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives.
The Journal of biological chemistry 1992;267(17):11769-76.
1992: K de Vreese; zeger debyser; Anne-Mieke Vandamme; Rudi Pauwels; Jan Desmyter; E de Clercq; Jozef Anne
Resistance of human immunodeficiency virus type 1 reverse transcriptase to TIBO derivatives induced by site-directed mutagenesis.
Virology 1992;188(2):900-4.
1992: Rudi Pauwels; Koen Andries; zeger debyser; M Kukla; Dominique Schols; Jan Desmyter; E De Clercq; P A Janssen
TIBO derivatives: a new class of highly potent and specific inhibitors of HIV-1 replication.
Biochemical Society transactions 1992;20(2):509-12.
1992: zeger debyser; Rudi Pauwels; M Baba; Jan Desmyter; E De Clercq
Common features in the interaction of tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives with the human immunodeficiency virus type 1 reverse transcriptase.
Molecular pharmacology 1992;41(5):963-8.
1992: zeger debyser; Rudi Pauwels; Koen Andries; Jan Desmyter; Y Engelborghs; P A Janssen; E De Clercq
Allosteric inhibition of human immunodeficiency virus type 1 reverse transcriptase by tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-one and -thione compounds.
Molecular pharmacology 1992;41(1):203-8.
1992: zeger debyser; Rudi Pauwels; Koen Andries; E De Clercq
Specific HIV-1 reverse transcriptase inhibitors.
Journal of enzyme inhibition 1992;6(1):47-53.
1991: zeger debyser; Rudi Pauwels; Koen Andries; Jan Desmyter; M Kukla; P A Janssen; E De Clercq
An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(4):1451-5.