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Giuseppe Campiani

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Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Joanne Lysaght; Elaina N Maginn; Paul V Browne; Giuseppe Campiani; Mark P Lawler; Jacqueline M Ryan; Navin K Verma; D Clive Williams; Daniela M Zisterer; Anthony M McElligott
The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.

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All Publications

2013: Stefania Butini; Walter Cabri; Giuseppe Campiani; Diana Celona; Sabrina Dallavalle; Filomena Fezza; Sandra Gemma; Samuele Maramai; Lucio Merlini; Patrizia Minetti; Raffaella Napolitano; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Bioorganic & medicinal chemistry letters 2013;23(2):492-5.
2013: Stefania Butini; Giuseppe Campiani; Alice Casagni; Emanuele Gabellieri; Mariateresa Giustiniano; Egeria Guarino; Paul B Huleatt; Valeria La Pietra; Luciana Marinelli; Ettore Novellino; Nicola Relitti; Margherita Brindisi; Sandra Gemma
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorganic & medicinal chemistry letters 2013;23(1):85-9.
2013: Joanne Lysaght; Elaina N Maginn; Paul V Browne; Giuseppe Campiani; Mark P Lawler; Jacqueline M Ryan; Navin K Verma; D Clive Williams; Daniela M Zisterer; Anthony M McElligott
The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.
International journal of oncology 2013;42(1):239-46.
2012: Sandra Gemma; Roberta Gualdani; Annette Habluetzel; Gagan Kukreja; Sanil Kunjir; Stefania Lamponi; Leonardo Lucantoni; Rowena E Martin; Maria Rosa Moncelli; Ettore Novellino; Luisa Savini; Robert L Summers; Francesco Tadini Buoninsegni; Donatella Taramelli; massimo valoti; Gianluca Bartolommei; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Caterina Camodeca; Giuseppe Campiani; Isabella Fiorini; Emanuele Gabellieri; Stefania Butini
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
Journal of medicinal chemistry 2012;55(23):10387-404.
2012: Sandra Gemma; Simone Giovani; Ettore Novellino; Maria Penzo; Luisa Savini; Pierangela Tripaldi; Margherita Brindisi; Simone Brogi; Stefania Butini; Giuseppe Campiani; Isabella Fiorini; Michael J Blackman
Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.
Bioorganic & medicinal chemistry letters 2012;22(16):5317-21.
2012: Stefania Butini; Sandra Gemma; Giuseppe Campiani
A straightforward approach for engineering efficacy and selectivity at GPCRs.
Journal of medicinal chemistry 2012;55(15):6687-8.
2012: Sandra Gemma; Beatrice Gorelli; Giovanna Guiso; Bhupendra P Joshi; Stefania Lamponi; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Matthias Rottmann; Salvatore Sanna Coccone; simona saponara; Luisa Savini; Robert L Summers; Donatella Taramelli; Rowena E Martin; Nicoletta Basilico; Matteo Bernetti; Maria Cruz Bonache de Marcos; Simone Brogi; Reto Brun; S Caccia; Caterina Camodeca; Giuseppe Campiani; Stefania Butini
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.
Journal of medicinal chemistry 2012;55(15):6948-67.
2012: Stefania Butini; Walter Cabri; Giuseppe Campiani; Antonio Caprioli; Stefano Di Serio; Filomena Fezza; Grazia Gallo; Sandra Gemma; Samuele Maramai; Patrizia Minetti; Sindu Ros; M Antonietta Stasi; Emanuela Talamonti; Silvia Vincenti; Giuseppe Borrelli; Franco Borsini; Margherita Brindisi; Mauro Maccarrone
Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.
Journal of medicinal chemistry 2012;55(15):6898-915.
2011: Gianluca Bartolommei; Stefania Butini; Caterina Camodeca; Giuseppe Campiani; Sandra Gemma; David Lewis; Maria Rosa Moncelli; Francesco Tadini Buoninsegni; Giuseppe Inesi
The Ca2+-ATPase (SERCA1) is inhibited by 4-aminoquinoline derivatives through interference with catalytic activation by Ca2+, whereas the ATPase E2 state remains functional.
The Journal of biological chemistry 2011;286(44):38383-9.
2011: Sandra Gemma; Sanil Kunjir; Vittoria Moretti; Ettore Novellino; Silvia Parapini; Donatella Taramelli; Salvatore Sanna Coccone; Nicoletta Basilico; Margherita Brindisi; Simone Brogi; Giuseppe Campiani; Stefania Butini
Synthesis and antiplasmodial activity of bicyclic dioxanes as simplified dihydroplakortin analogues.
Journal of medicinal chemistry 2011;54(16):5949-53.
2011: Sandra Gemma; Gianluca Giorgi; Bhupendra P Joshi; Ettore Novellino; Mario Salmona; Luisa Savini; Orazio Taglialatela-Scafati; Pierangela Tripaldi; Silvio Caccia; Giuseppe Campiani; Laura Colombo; Isabella Fiorini; Gianluigi Forloni; Claudia Fracasso; Margherita Brindisi; Stefania Butini
Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils.
Organic & biomolecular chemistry 2011;9(14):5137-48.
2011: Raminta Venskutonyte; Elena Antón Valadés; Salvatore Valenti; Ahmad Amir; Margherita Brindisi; Stefania Butini; Giuseppe Campiani; Salvatore Sanna Coccone; Karla Frydenvang; Sandra Gemma; Egeria Guarino; Jette S Kastrup; Vinod Kumar; Samuele Maramai; Ettore Novellino; Darryl S Pickering
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
Journal of medicinal chemistry 2011;54(13):4793-805.
2011: Stefania Butini; Giuseppe Campiani; Marcella Facchini; Isabella Fiorini; Federico Focher; Sandra Gemma; Aristotele Karytinos; Andrea Lossani; Giuseppe Borrelli; Margherita Brindisi; Ettore Novellino; Alberta Samuele; Samantha Zanoli; giovanni maga
Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants.
Bioorganic & medicinal chemistry letters 2011;21(13):3935-8.
2011: Sandra Gemma; Stefania Butini; Giuseppe Campiani; Margherita Brindisi; Samantha Zanoli; Maria Pia Romano; Pierangela Tripaldi; Luisa Savini; Isabella Fiorini; Giuseppe Borrelli; Ettore Novellino; giovanni maga
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
Bioorganic & medicinal chemistry letters 2011;21(9):2776-9.
2011: Stefania Butini; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Andrea Lossani; Anna Maria Ponte; Andrea Torti; giovanni maga; Luciana Marinelli; Valeria La Pietra; Isabella Fiorini; Stefania Lamponi; Giuseppe Campiani; Daniela M Zisterer; Seema-Maria Nathwani; Stefania Sartini; Concettina La Motta; Federico Da Settimo; Ettore Novellino; Federico Focher
Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.
Journal of medicinal chemistry 2011;54(5):1401-20.
2011: E N Maginn; Paul V Browne; Patrick J Hayden; Elisabeth Vandenberghe; B MacDonagh; P Evans; M Goodyer; P Tewari; Giuseppe Campiani; Stefania Butini; D Clive Williams; Daniela M Zisterer; Mark Lawler; A M McElligott
PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
British journal of cancer 2011;104(2):281-9.
2011: Pradeep R Patil; Sandra Gemma; Giuseppe Campiani; Alister G Craig
Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate.
Malaria journal 2011;10():348.
2010: Seema-Maria Nathwani; Suzanne Cloonan; Maeve Stronach; Giuseppe Campiani; Mark Lawler; D Clive Williams; Daniela M Zisterer
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
Oncology reports 2010;24(6):1499-507.
2010: Sandra Gemma; Valter Travagli; Luisa Savini; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Malaria chemotherapy: recent advances in drug development.
Recent patents on anti-infective drug discovery 2010;5(3):195-225.
2010: Seema-Maria Nathwani; Stephen Butler; Darren Fayne; Naomi N McGovern; Balazs Sarkadi; Mary J Meegan; David Lloyd; Giuseppe Campiani; Mark Lawler; D Clive Williams; Daniela M Zisterer
Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
Cancer chemotherapy and pharmacology 2010;66(3):585-96.
2010: Sandra A Bright; Giuseppe Campiani; Michael W N Deininger; Mark Lawler; D Clive Williams; Daniela M Zisterer
Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Biochemical pharmacology 2010;80(1):31-8.
2010: Stefania Butini; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Vinod Kumar; Egeria Guarino; Giuseppe Borrelli; Isabella Fiorini; Ettore Novellino; Caterina Fattorusso; Marco Persico; Nausicaa Orteca; Karin Sandager-Nielsen; Thomas Amos Jacobsen; Kim Madsen; Jorgen Scheel-Kruger; Sandra Gemma
Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors.
Journal of medicinal chemistry 2010;53(12):4803-7.
2010: Sandra Gemma; Emanuele Gabellieri; Salvatore Sanna Coccone; Francesc Martí; Orazio Taglialatela-Scafati; Ettore Novellino; Giuseppe Campiani; Stefania Butini
Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues.
The Journal of organic chemistry 2010;75(7):2333-40.
2010: Andrea Cappelli; Stefania Butini; Antonella Brizzi; Sandra Gemma; Salvatore Valenti; Germano Giuliani; Maurizio Anzini; Laura Mennuni; Giuseppe Campiani; Vittorio Brizzi; Salvatore Vomero
The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium.
Current topics in medicinal chemistry 2010;10(5):504-26.
2010: Seema-Maria Nathwani; Stephen Butler; Mary J Meegan; Giuseppe Campiani; Mark Lawler; D Clive Williams; Daniela M Zisterer
Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
Cancer chemotherapy and pharmacology 2010;65(2):289-300.
2009: Stefania Butini; Roberta Budriesi; Michel Hamon; Elena Morelli; Sandra Gemma; Margherita Brindisi; Giuseppe Borrelli; Ettore Novellino; Isabella Fiorini; Pierfranco Ioan; Alberto Chiarini; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; S Caccia; Giuseppe Campiani
Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.
Journal of medicinal chemistry 2009;52(21):6946-50.
2009: Anthony M McElligott; Elaina N Maginn; Lisa M Greene; Siobhan McGuckin; Amjad Hayat; Paul V Browne; Stefania Butini; Giuseppe Campiani; Mark A Catherwood; Elisabeth Vandenberghe; D Clive Williams; Daniela M Zisterer; Mark Lawler
The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
Cancer research 2009;69(21):8366-75.
2009: Ferlini Cristiano; Lucia Cicchillitti; Giuseppina Raspaglio; Silvia Bartollino; Samanta Cimitan; Carlo Bertucci; Simona Mozzetti; Daniela Gallo; Marco Persico; Caterina Fattorusso; Giuseppe Campiani; Giovanni Scambia
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.
Cancer research 2009;69(17):6906-14.
2009: Sandra Gemma; Luisa Savini; Maria Altarelli; Pierangela Tripaldi; Luisa Chiasserini; Salvatore Sanna Coccone; Vinod Kumar; Caterina Camodeca; Giuseppe Campiani; Ettore Novellino; Sandra Clarizio; Giovanni Delogu; Stefania Butini
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
Bioorganic & medicinal chemistry 2009;17(16):6063-72.
2009: Elena Morelli; Sandra Gemma; Roberta Budriesi; Giuseppe Campiani; Ettore Novellino; Caterina Fattorusso; Bruno Catalanotti; Salvatore Sanna Coccone; Sindu Ros; Giuseppe Borrelli; Marco Persico; Isabella Fiorini; Vito Nacci; Pierfranco Ioan; Alberto Chiarini; Michel Hamon; Alfredo Cagnotto; Tiziana Mennini; Claudia Fracasso; Milena Colovic; S Caccia; Stefania Butini
Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.
Journal of medicinal chemistry 2009;52(11):3548-62.
2009: Stefania Butini; Margherita Brindisi; Sandro Cosconati; Luciana Marinelli; Giuseppe Borrelli; Salvatore Sanna Coccone; Anna Ramunno; Giuseppe Campiani; Ettore Novellino; Samantha Zanoli; Alberta Samuele; Gianluca Giorgi; Alberto Bergamini; Michela Di Mattia; Silvana Lalli; Bruno Galletti; Sandra Gemma; giovanni maga
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations.
Journal of medicinal chemistry 2009;52(4):1224-8.
2009: Sandra A Bright; Lisa M Greene; Tom F Greene; Giuseppe Campiani; Stefania Butini; Margherita Brindisi; Mark Lawler; Mary J Meegan; D Clive Williams; Daniela M Zisterer
The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
Biochemical pharmacology 2009;77(3):310-21.
2009: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Bhupendra P Joshi; Gagan Kukreja; Salvatore Sanna Coccone; Matteo Bernetti; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Vanessa Yardley; Simon Croft; Sonja Keller-Maerki; Matthias Rottmann; Reto Brun; Massimo Coletta; Stefano Marini; Giovanna Guiso; S Caccia; Caterina Fattorusso
Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials.
Journal of medicinal chemistry 2009;52(2):502-13.
2009: Stefania Butini; Sandra Gemma; Giuseppe Campiani; Silvia Franceschini; Francesco Trotta; Marianna Borriello; Nicoletta Ceres; Sindu Ros; Salvatore Sanna Coccone; Matteo Bernetti; Meri De Angelis; Margherita Brindisi; Vito Nacci; Isabella Fiorini; Ettore Novellino; Alfredo Cagnotto; Tiziana Mennini; Karin Sandager-Nielsen; Jesper Andreasen; Jorgen Scheel-Kruger; Jens D Mikkelsen; Caterina Fattorusso
Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.
Journal of medicinal chemistry 2009;52(1):151-69.
2008: Stefania Butini; Emanuele Gabellieri; Paul Brady Huleatt; Giuseppe Campiani; Silvia Franceschini; Margherita Brindisi; Sindu Ros; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Gianluca Giorgi; Sandra Gemma
An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds.
The Journal of organic chemistry 2008;73(21):8458-68.
2008: Stefania Butini; Darryl S Pickering; Elena Morelli; Salvatore Sanna Coccone; Francesco Trotta; Meri De Angelis; Egeria Guarino; Isabella Fiorini; Giuseppe Campiani; Ettore Novellino; Arne Schousboe; Jeppe K Christensen; Sandra Gemma
1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Journal of medicinal chemistry 2008;51(20):6614-8.
2008: Stefania Butini; Egeria Guarino; Giuseppe Campiani; Margherita Brindisi; Salvatore Sanna Coccone; Isabella Fiorini; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Sandra Gemma
Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.
Bioorganic & medicinal chemistry letters 2008;18(19):5213-6.
2008: Samantha Zanoli; Sandra Gemma; Stefania Butini; Margherita Brindisi; Bhupendra P Joshi; Giuseppe Campiani; Caterina Fattorusso; Marco Persico; Emmanuele Crespan; Reynel Cancio; Silvio Spadari; Ulrich Hübscher; giovanni maga
Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.
Biochemical pharmacology 2008;76(2):156-68.
2008: Stefania Butini; Giuseppe Campiani; Marianna Borriello; Sandra Gemma; Alessandro Panico; Marco Persico; Bruno Catalanotti; Sindu Ros; Margherita Brindisi; Marianna Agnusdei; Isabella Fiorini; Vito Nacci; Ettore Novellino; Tatyana Belinskaya; Ashima Saxena; Caterina Fattorusso
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry 2008;51(11):3154-70.
2008: M Antonietta Stasi; Stefano Di Serio; Mario Vertechy; Antonio Schiavone; Orlando Ghirardi; Patrizia Minetti; Giuseppe Campiani; Franco Borsini; Paolo Carminati
ST2472: a new potential antipsychotic with very low liability to induce side-effects.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2008;11(3):309-19.
2008: Navin K Verma; Eugene Dempsey; Jennifer Conroy; Peter Olwell; Anthony M Mcelligott; Anthony M Davies; Dermot Kelleher; Stefania Butini; Giuseppe Campiani; D Clive Williams; Daniela M Zisterer; Mark Lawler; Yuri Volkov
A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
Journal of molecular medicine (Berlin, Germany) 2008;86(4):457-69.
2008: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Salvatore Sanna Coccone; Bhupendra P Joshi; Marco Persico; Vito Nacci; Isabella Fiorini; Ettore Novellino; Ernesto Fattorusso; Orazio Taglialatela-Scafati; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Silvia Parapini; Giulia Morace; Vanessa Yardley; Simon L Croft; Massimiliano Coletta; Stefano Marini; Caterina Fattorusso
Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies.
Journal of medicinal chemistry 2008;51(5):1278-94.
2008: Caterina Fattorusso; Giuseppe Campiani; Gagan Kukreja; Marco Persico; Stefania Butini; Maria Pia Romano; Maria Altarelli; Sindu Ros; Margherita Brindisi; Luisa Savini; Ettore Novellino; Vito Nacci; Ernesto Fattorusso; Silvia Parapini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Simon L Croft; Marianna Borriello; Sandra Gemma
Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents.
Journal of medicinal chemistry 2008;51(5):1333-43.
2008: Lisa M Greene; Giuseppe Campiani; Mark Lawler; D Clive Williams; Daniela M Zisterer
BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.
Molecular pharmacology 2008;73(2):419-30.
2007: Sandra Gemma; Gagan Kukreja; Giuseppe Campiani; Stefania Butini; Matteo Bernetti; Bhupendra P Joshi; Luisa Savini; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Alessia Bertamino; Ettore Novellino; Marco Persico; Bruno Catalanotti; Caterina Fattorusso
Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling.
Bioorganic & medicinal chemistry letters 2007;17(13):3535-9.
2007: Lisa M Greene; Liam Kelly; Valeria Onnis; Giuseppe Campiani; Mark Lawler; D Clive Williams; Daniela M Zisterer
STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
The Journal of pharmacology and experimental therapeutics 2007;321(1):288-97.
2007: Sandra Gemma; Giuseppe Campiani; Stefania Butini; Gagan Kukreja; Bhupendra P Joshi; Marco Persico; Bruno Catalanotti; Ettore Novellino; Ernesto Fattorusso; Vito Nacci; Luisa Savini; Donatella Taramelli; Nicoletta Basilico; Giulia Morace; Vanessa Yardley; Caterina Fattorusso
Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore.
Journal of medicinal chemistry 2007;50(4):595-8.
2006: Caterina Fattorusso; Giuseppe Campiani; Bruno Catalanotti; Marco Persico; Nicoletta Basilico; Silvia Parapini; Donatella Taramelli; Claudio Campagnuolo; Ernesto Fattorusso; Adriana Romano; Orazio Taglialatela-Scafati
Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents.
Journal of medicinal chemistry 2006;49(24):7088-94.
2006: Sandra Gemma; Gagan Kukreja; Caterina Fattorusso; Marco Persico; Maria P Romano; Maria Altarelli; Luisa Savini; Giuseppe Campiani; Ernesto Fattorusso; Nicoletta Basilico; Donatella Taramelli; Vanessa Yardley; Stefania Butini
Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains.
Bioorganic & medicinal chemistry letters 2006;16(20):5384-8.
2006: Gagan Kukreja; Giuseppe Campiani; Jitender M Khurana; Bhupendra P Joshi; Surinder K Grover
Unexpected formation of hydroxybiphenylmethane derivatives and some new observations on Labat test.
Natural product research 2006;20(12):1150-4.
2006: L B McGrath; Valeria Onnis; Giuseppe Campiani; D Clive Williams; Daniela M Zisterer; Margaret M Mc Gee
Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn2+-dependent acidic endonuclease activity.
Apoptosis : an international journal on programmed cell death 2006;11(9):1473-87.
2006: Jude M Mulligan; Lisa M Greene; Suzanne Cloonan; Margaret M Mc Gee; Valeria Onnis; Giuseppe Campiani; Caterina Fattorusso; Mark Lawler; D Clive Williams; Daniela M Zisterer
Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
Molecular pharmacology 2006;70(1):60-70.
2006: Sandra Gemma; Emanuele Gabellieri; Paul Huleatt; Caterina Fattorusso; Marianna Borriello; Bruno Catalanotti; Stefania Butini; Meri De Angelis; Ettore Novellino; Vito Nacci; Tatyana Belinskaya; Ashima Saxena; Giuseppe Campiani
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Journal of medicinal chemistry 2006;49(11):3421-5.
2006: Jacques-Philippe Colletier; Benoît Sanson; Florian Nachon; Emanuele Gabellieri; Caterina Fattorusso; Giuseppe Campiani; Martin Weik
Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.
Journal of the American Chemical Society 2006;128(14):4526-7.
2005: Caterina Fattorusso; Sandra Gemma; Stefania Butini; Paul Huleatt; Bruno Catalanotti; Marco Persico; Meri De Angelis; Isabella Fiorini; Vito Nacci; Anna Ramunno; Manuela Rodriquez; Giovanni Greco; Ettore Novellino; Alberto Bergamini; Stefano Marini; Massimo Coletta; giovanni maga; Silvio Spadari; Giuseppe Campiani
Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.
Journal of medicinal chemistry 2005;48(23):7153-65.
2005: Lisa M Greene; Marina N Fleeton; Jude M Mulligan; Chikkanna Gowda; Brian J Sheahan; Gregory J Atkins; Giuseppe Campiani; Vito Nacci; Mark Lawler; D Clive Williams; Daniela M Zisterer
The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
Oncology reports 2005;14(5):1357-63.
2005: giovanni maga; Sandra Gemma; Caterina Fattorusso; Giada A Locatelli; Stefania Butini; Marco Persico; Gagan Kukreja; Maria Pia Romano; Luisa Chiasserini; Luisa Savini; Ettore Novellino; Vito Nacci; Silvio Spadari; Giuseppe Campiani
Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.
Biochemistry 2005;44(28):9637-44.
2005: Margaret M Mc Gee; Sandra Gemma; Stefania Butini; Anna Ramunno; Daniela M Zisterer; Caterina Fattorusso; Bruno Catalanotti; Gagan Kukreja; Isabella Fiorini; Claudio Pisano; Carla Cucco; Ettore Novellino; Vito Nacci; D Clive Williams; Giuseppe Campiani
Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target.
Journal of medicinal chemistry 2005;48(13):4367-77.
2005: Giuseppe Campiani; Caterina Fattorusso; Stefania Butini; Alessandra Gaeta; Marianna Agnusdei; Sandra Gemma; Marco Persico; Bruno Catalanotti; Luisa Savini; Vito Nacci; Ettore Novellino; Harold W Holloway; Nigel H Greig; Tatyana Belinskaya; James M Fedorko; Ashima Saxena
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry 2005;48(6):1919-29.
2005: Giuseppe Campiani; Stefania Butini; Caterina Fattorusso; Francesco Trotta; Sandra Gemma; Bruno Catalanotti; Vito Nacci; Isabella Fiorini; Alfredo Cagnotto; Ilario Mereghetti; Tiziana Mennini; Patrizia Minetti; M Assunta Di Cesare; M Antonietta Stasi; Stefano Di Serio; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.
Journal of medicinal chemistry 2005;48(6):1705-8.
2005: Ferlini Cristiano; Giuseppina Raspaglio; Simona Mozzetti; Lucia Cicchillitti; Flavia Filippetti; Daniela Gallo; Caterina Fattorusso; Giuseppe Campiani; Giovanni Scambia
The seco-taxane IDN5390 is able to target class III beta-tubulin and to overcome paclitaxel resistance.
Cancer research 2005;65(6):2397-405.
2005: Anne Frandsen; Darryl S Pickering; Bente Vestergaard; Christina Kasper; Bettina Bryde Nielsen; Jeremy R Greenwood; Giuseppe Campiani; Caterina Fattorusso; Michael Gajhede; Arne Schousboe; Jette S Kastrup
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.
Molecular pharmacology 2005;67(3):703-13.
2005: Annamarie Rogers; Gabriele Schmuck; Gabriele Scholz; Roger Griffiths; Clive Meredith; Arne Schousboe; Giuseppe Campiani; D Clive Williams
Improvements in an in-vitro assay for excitotoxicity by measurement of early gene (c-fos mRNA) levels.
Archives of toxicology 2005;79(3):129-39.
2004: David Lloyd; Rosario B Hughes; Daniela M Zisterer; D Clive Williams; Caterina Fattorusso; Bruno Catalanotti; Giuseppe Campiani; Mary J Meegan
Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor.
Journal of medicinal chemistry 2004;47(23):5612-5.
2004: Margaret M Mc Gee; Lisa M Greene; Susan Ledwidge; Giuseppe Campiani; Vito Nacci; Mark Lawler; D Clive Williams; Daniela M Zisterer
Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
The Journal of pharmacology and experimental therapeutics 2004;310(3):1084-95.
2004: Giada A Locatelli; Giuseppe Campiani; Reynel Cancio; Elena Morelli; Anna Ramunno; Sandra Gemma; Ulrich Hübscher; Silvio Spadari; giovanni maga
Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex.
Antimicrobial agents and chemotherapy 2004;48(5):1570-80.
2004: Giuseppe Campiani; Stefania Butini; Caterina Fattorusso; Bruno Catalanotti; Sandra Gemma; Vito Nacci; Elena Morelli; Alfredo Cagnotto; Ilario Mereghetti; Tiziana Mennini; Miriana Carli; Patrizia Minetti; M Assunta Di Cesare; Domenico mastroianni; Nazzareno Scafetta; Bruno Galletti; M Antonietta Stasi; Massimo Castorina; Licia Pacifici; Mario Vertechy; Stefano Di Serio; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.
Journal of medicinal chemistry 2004;47(1):143-57.
2003: Tiziana Mennini; Elena Fumagalli; Marco Gobbi; Caterina Fattorusso; Bruno Catalanotti; Giuseppe Campiani
Substrate inhibitors and blockers of excitatory amino acid transporters in the treatment of neurodegeneration: critical considerations.
European journal of pharmacology 2003;479(1-3):291-6.
2003: Jude M Mulligan; Giuseppe Campiani; Anna Ramunno; Vito Nacci; Daniela M Zisterer
Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human astrocytoma cells by the pyrrolo-1,5-benzoxazepine, PBOX-21.
Biochimica et biophysica acta 2003;1639(1):43-52.
2003: Giuseppe Campiani; Stefania Butini; Francesco Trotta; Caterina Fattorusso; Bruno Catalanotti; Francesca Aiello; Sandra Gemma; Vito Nacci; Ettore Novellino; Jennifer Ann Stark; Alfredo Cagnotto; Elena Fumagalli; Francesco Carnovali; Luigi Cervo; Tiziana Mennini
Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors.
Journal of medicinal chemistry 2003;46(18):3822-39.
2003: Colin Sinclair; Helen Reavy; Angus Grieve; Arne Schousboe; Elena Morelli; Ettore Novellino; Giuseppe Campiani; Roger Griffiths
Inherent desensitisation-preventing properties of a novel, subtype-selective AMPA receptor agonist, (S)-CPW 399, as a possible explanation for its excitotoxic action in cultured cerebellar granule cells.
Neurochemistry international 2003;42(6):499-510.
2003: Luisa Savini; Alessandra Gaeta; Caterina Fattorusso; Bruno Catalanotti; Giuseppe Campiani; Luisa Chiasserini; Cesare Pellerano; Ettore Novellino; Dawn McKissic; Ashima Saxena
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry 2003;46(1):1-4.
2003: Giuseppe Campiani; Caterina Fattorusso; Meri De Angelis; Bruno Catalanotti; Stefania Butini; Roberto Fattorusso; Isabella Fiorini; Vito Nacci; Ettore Novellino
Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases.
Current pharmaceutical design 2003;9(8):599-625.
2002: Giuseppe Campiani; Anna Ramunno; Isabella Fiorini; Vito Nacci; Elena Morelli; Ettore Novellino; Mara Goegan; Tiziana Mennini; Stephen Sullivan; Daniela M Zisterer; Clive D Williams
Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR).
Journal of medicinal chemistry 2002;45(19):4276-81.
2002: Margaret M Mc Gee; Giuseppe Campiani; Anna Ramunno; Vito Nacci; Mark Lawler; D Clive Williams; Daniela M Zisterer
Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.
The Journal of biological chemistry 2002;277(21):18383-9.
2002: Margaret M Mc Gee; Edel Hyland; Giuseppe Campiani; Anna Ramunno; Vito Nacci; Daniela M Zisterer
Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6.
FEBS letters 2002;515(1-3):66-70.
2002: Giuseppe Campiani; Stefania Butini; Sandra Gemma; Vito Nacci; Caterina Fattorusso; Bruno Catalanotti; Gianluca Giorgi; Alfredo Cagnotto; Mara Goegan; Tiziana Mennini; Patrizia Minetti; M Assunta Di Cesare; Domenico mastroianni; Nazzareno Scafetta; Bruno Galletti; M Antonietta Stasi; Massimo Castorina; Licia Pacifici; Orlando Ghirardi; Ornella Tinti; Paolo Carminati
Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies.
Journal of medicinal chemistry 2002;45(2):344-59.
2002: Giuseppe Campiani; Anna Ramunno; giovanni maga; Vito Nacci; Caterina Fattorusso; Bruno Catalanotti; Elena Morelli; Ettore Novellino
Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives.
Current pharmaceutical design 2002;8(8):615-57.
2001: Giuseppe Campiani; Elena Morelli; Vito Nacci; Caterina Fattorusso; Anna Ramunno; Ettore Novellino; J Greenwood; Tommy Liljefors; Roger Griffiths; Colin Sinclair; Helen Reavy; Anders Skov Kristensen; Darryl S Pickering; Arne Schousboe; Alfredo Cagnotto; Elena Fumagalli; Tiziana Mennini
Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Journal of medicinal chemistry 2001;44(26):4501-4.
2001: giovanni maga; Anna Ramunno; Vito Nacci; Giada A Locatelli; Silvio Spadari; Isabella Fiorini; Fausto Baldanti; Stefania Paolucci; Maurizio Zavattoni; Alberto Bergamini; Bruno Galletti; S Muck; Ulrich Hubscher; G Giorgi; Giovanna Guiso; S Caccia; Giuseppe Campiani
The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.
The Journal of biological chemistry 2001;276(48):44653-62.
2001: Daniela M Zisterer; M M McGee; Giuseppe Campiani; Anna Ramunno; Caterina Fattorusso; Vito Nacci; Mark Lawler; D Clive Williams
Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents.
Biochemical Society transactions 2001;29(Pt 6):704-6.
2001: Giuseppe Campiani; Meri De Angelis; S Armaroli; Caterina Fattorusso; Bruno Catalanotti; Anna Ramunno; Vito Nacci; Ettore Novellino; Christof Grewer; D Ionescu; Thomas Rauen; Roger Griffiths; Colin Sinclair; Elena Fumagalli; Tiziana Mennini
A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
Journal of medicinal chemistry 2001;44(16):2507-10.
2001: Luisa Savini; Giuseppe Campiani; Alessandra Gaeta; Cesare Pellerano; Caterina Fattorusso; Luisa Chiasserini; James M Fedorko; Ashima Saxena
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters 2001;11(13):1779-82.
2001: Giuseppe Campiani; Francesca Aiello; M Fabbrini; Elena Morelli; Anna Ramunno; S Armaroli; Vito Nacci; Antonio Garofalo; Giovanni Greco; Ettore Novellino; giovanni maga; Silvio Spadari; Alberto Bergamini; L Ventura; Barbara Bongiovanni; Marcella Capozzi; Francesca Bolacchi; Stefano Marini; Massimo Coletta; Giovanna Guiso; S Caccia
Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent.
Journal of medicinal chemistry 2001;44(3):305-15.
2001: Margaret M Mc Gee; Giuseppe Campiani; Anna Ramunno; Caterina Fattorusso; Vito Nacci; Mark Lawler; D Clive Williams; Daniela M Zisterer
Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
The Journal of pharmacology and experimental therapeutics 2001;296(1):31-40.
2000: Daniela M Zisterer; Giuseppe Campiani; Vito Nacci; D Clive Williams
Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.
The Journal of pharmacology and experimental therapeutics 2000;293(1):48-59.
2000: Giuseppe Campiani; M Fabbrini; Elena Morelli; Vito Nacci; Giovanni Greco; Ettore Novellino; giovanni maga; Silvio Spadari; Alberto Bergamini; E Faggioli; Ilaria Uccella; Francesca Bolacchi; Stefano Marini; Massimo Coletta; Claudia Fracasso; S Caccia
Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents.
Antiviral chemistry & chemotherapy 2000;11(2):141-55.
1999: Giuseppe Campiani; Elena Morelli; M Fabbrini; Vito Nacci; Giovanni Greco; Ettore Novellino; Anna Ramunno; giovanni maga; Silvio Spadari; G Caliendo; Alberto Bergamini; E Faggioli; Ilaria Uccella; Francesca Bolacchi; Stefano Marini; Massimo Coletta; A Nacca; S Caccia
Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity.
Journal of medicinal chemistry 1999;42(21):4462-70.
1999: Giuseppe Campiani; Elena Morelli; Sandra Gemma; Vito Nacci; Stefania Butini; Michel Hamon; Ettore Novellino; Giovanni Greco; Alfredo Cagnotto; Mara Goegan; Luigi Cervo; F Dalla Valle; Claudia Fracasso; S Caccia; Tiziana Mennini
Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Journal of medicinal chemistry 1999;42(21):4362-79.
1999: Nouri Neamati; Jim A Turpin; Heather E Winslow; JL Christensen; K Williamson; Ann H Orr; William G Rice; Yves Pommier; Antonio Garofalo; Antonella Brizzi; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Thiazolothiazepine inhibitors of HIV-1 integrase.
Journal of medicinal chemistry 1999;42(17):3334-41.
1998: Giuseppe Campiani; Vito Nacci; S Bechelli; S M Ciani; Antonio Garofalo; Isabella Fiorini; H Wikström; P de Boer; Y Liao; P G Tepper; Alfredo Cagnotto; Tiziana Mennini
New antipsychotic agents with serotonin and dopamine antagonist properties based on a pyrrolo[2,1-b][1,3]benzothiazepine structure.
Journal of medicinal chemistry 1998;41(20):3763-72.
1998: Giuseppe Campiani; Alan P Kozikowski; Shaomeng Wang; L Ming; Vito Nacci; A Saxena; B P Doctor
Synthesis and anticholinesterase activity of huperzine A analogues containing phenol and catechol replacements for the pyridone ring.
Bioorganic & medicinal chemistry letters 1998;8(11):1413-8.
1998: Daniela M Zisterer; N Hance; Giuseppe Campiani; A Garofalo; Vito Nacci; D Clive Williams
Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: absence of correlation with binding to the peripheral-type benzodiazepine binding site.
Biochemical pharmacology 1998;55(4):397-403.
1997: Giuseppe Campiani; Andrea Cappelli; Vito Nacci; Maurizio Anzini; Salvatore Vomero; Michel Hamon; Alfredo Cagnotto; Claudia Fracasso; C Uboldi; S Caccia; S Consolo; Tiziana Mennini
Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Journal of medicinal chemistry 1997;40(22):3670-8.
1997: Federico Corelli; Fabrizio Manetti; Andrea Tafi; Giuseppe Campiani; Vito Nacci; Maurizio Botta
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model.
Journal of medicinal chemistry 1997;40(1):125-31.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; S M Ciani; Giovanni Greco; Ettore Novellino; D C Williams; Daniela M Zisterer; M J Woods; C Mihai; C Manzoni; Tiziana Mennini
Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands.
Journal of medicinal chemistry 1996;39(18):3435-50.
1996: Giuseppe Campiani; Isabella Fiorini; M P De Filippis; S M Ciani; Antonio Garofalo; Vito Nacci; Gianluca Giorgi; A Sega; Maurizio Botta; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo; C Manzoni; Tiziana Mennini
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blockers.
Journal of medicinal chemistry 1996;39(15):2922-38.
1996: Giuseppe Campiani; Vito Nacci; Isabella Fiorini; M P De Filippis; Antonio Garofalo; Giovanni Greco; Ettore Novellino; Sergio Altamura; L Di Renzo
Pyrrolobenzothiazepinones and pyrrolobenzoxazepinones: novel and specific non-nucleoside HIV-1 reverse transcriptase inhibitors with antiviral activity.
Journal of medicinal chemistry 1996;39(14):2672-80.
1995: Alessandro Dalpiaz; V Bertolasi; Pier Andrea Borea; Vito Nacci; Isabella Fiorini; Giuseppe Campiani; Tiziana Mennini; C Manzoni; Ettore Novellino; Giovanni Greco
A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Journal of medicinal chemistry 1995;38(23):4730-8.
1995: Giuseppe Campiani; Antonio Garofalo; Isabella Fiorini; Maurizio Botta; Vito Nacci; Andrea Tafi; Alberto Chiarini; Roberta Budriesi; Giancarlo Bruni; M R Romeo
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Journal of medicinal chemistry 1995;38(22):4393-410.
1994: Giovanni Greco; Ettore Novellino; Isabella Fiorini; Vito Nacci; Giuseppe Campiani; S M Ciani; Antonio Garofalo; P Bernasconi; Tiziana Mennini
A comparative molecular field analysis model for 6-arylpyrrolo[2,1-d] [1,5]benzothiazepines binding selectively to the mitochondrial benzodiazepine receptor.
Journal of medicinal chemistry 1994;37(24):4100-8.
1994: Isabella Fiorini; Vito Nacci; S M Ciani; Antonio Garofalo; Giuseppe Campiani; Luisa Savini; Ettore Novellino; Giovanni Greco; P Bernasconi; Tiziana Mennini
Novel ligands specific for mitochondrial benzodiazepine receptors: 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives. Synthesis, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 1994;37(10):1427-38.
1993: Antonio Garofalo; Giuseppe Campiani; Isabella Fiorini; Vito Nacci
Benzothiazine and benzothiazepine derivatives: synthesis and preliminary biological evaluation.
Farmaco (Società chimica italiana : 1989) 1993;48(2):275-83.
1991: Maurizio Anzini; Andrea Cappelli; Salvatore Vomero; Giuseppe Campiani; Alfredo Cagnotto; M Skorupska
Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines.
Farmaco (Società chimica italiana : 1989) 1991;46(12):1435-47.