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Peter Hart

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Sarah E Junco; Virgil Schirf; Alexander B Taylor; Renjing Wang; Vivian J Bardwell; Borries Demeler; John C Gaipa; Micah D Gearhart; Peter Hart; Chongwoo Kim
Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Mariya S Adachi; Peter Hart; Alexander B Taylor; Paul F Fitzpatrick
Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.
Samantha D Bouldin; Maxwell A Darch; Peter Hart; Caryn Outten
Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1.

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All Publications

2013: Sarah E Junco; Virgil Schirf; Alexander B Taylor; Renjing Wang; Vivian J Bardwell; Borries Demeler; John C Gaipa; Micah D Gearhart; Peter Hart; Chongwoo Kim
Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs.
Structure (London, England : 1993) 2013;21(4):665-71.
2012: Mariya S Adachi; Peter Hart; Alexander B Taylor; Paul F Fitzpatrick
Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes.
Biochemistry 2012;51(43):8690-7.
2012: Samantha D Bouldin; Maxwell A Darch; Peter Hart; Caryn Outten
Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1.
The Biochemical journal 2012;446(1):59-67.
2012: Nikolaos Biris; Felipe Diaz-Griffero; Miao Guo; Peter Hart; Alexander B Taylor; Andrei Tomashevski; Yang Yang; Dmitri N. Ivanov
Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(33):13278-83.
2012: Jeffry M Leitch; Cissy X Li; Lauren M Matthews; J Allen Baron; Xiaohang Cao; Peter Hart; Valeria Cizewski Culotta
Post-translational modification of Cu/Zn superoxide dismutase under anaerobic conditions.
Biochemistry 2012;51(2):677-85.
2011: Brandon M Childers; Borries Demeler; Peter Hart; Xiaohang Cao; Gregor G Weber; Karl E Klose
N-terminal residues of the Vibrio cholerae virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids.
The Journal of biological chemistry 2011;286(32):28644-55.
2011: Jordan M Chinai; Nicholas D Hargreaves; Peter Hart; Christopher A Morris; Lisa M Ryno; Alexander B Taylor; Adam R Urbach
Molecular recognition of insulin by a synthetic receptor.
Journal of the American Chemical Society 2011;133(23):8810-3.
2010: Sai V Seetharaman; Alexander B Taylor; Stephen Holloway; Peter Hart
Structures of mouse SOD1 and human/mouse SOD1 chimeras.
Archives of biochemistry and biophysics 2010;503(2):183-90.
2010: Ding Chen; Lei Lei; Chunxue Lu; Ahmad Galaleldeen; Peter Hart; Guangming Zhong
Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen.
Journal of bacteriology 2010;192(22):6017-24.
2010: Renjing Wang; Alexander B Taylor; Belinda Z Leal; Linda V Chadwell; Udayar Ilangovan; Angela K Robinson; Virgil Schirf; Peter Hart; Eileen M Lafer; Borries Demeler; Andrew Hinck; Donald McEwen; Chongwoo Kim
Polycomb group targeting through different binding partners of RING1B C-terminal domain.
Structure (London, England : 1993) 2010;18(8):966-75.
2010: Sai V Seetharaman; Duane D Winkler; Alexander B Taylor; Xiaohang Cao; Lisa J Whitson; Peter A Doucette; Joan Selverstone Valentine; Virgil Schirf; Borries Demeler; Mark C Carroll; Valeria Cizewski Culotta; Peter Hart
Disrupted zinc-binding sites in structures of pathogenic SOD1 variants D124V and H80R.
Biochemistry 2010;49(27):5714-25.
2010: José R Tormos; Alexander B Taylor; S Colette Daubner; Peter Hart; Paul F Fitzpatrick
Identification of a hypothetical protein from Podospora anserina as a nitroalkane oxidase.
Biochemistry 2010;49(24):5035-41.
2010: Olga N Pakhomova; Alexander B Taylor; Argentina Becker; Stephen P Holloway; T R Kannan; Joel Baseman; Peter Hart
Crystallization of community-acquired respiratory distress syndrome toxin from Mycoplasma pneumoniae.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 3):294-6.
2010: Zheng You; Xiaohang Cao; Alexander B Taylor; Peter Hart; Rodney L Levine
Characterization of a covalent polysulfane bridge in copper-zinc superoxide dismutase .
Biochemistry 2010;49(6):1191-8.
2009: Ahmad Galaleldeen; Richard W Strange; Lisa J Whitson; Svetlana Antonyuk; Narendra Narayana; Alexander B Taylor; Jonathan P Schuermann; Stephen P Holloway; S Samar Hasnain; Peter Hart
Structural and biophysical properties of metal-free pathogenic SOD1 mutants A4V and G93A.
Archives of biochemistry and biophysics 2009;492(1-2):40-7.
2009: Ashutosh Tiwari; Amir Liba; Se Hui Sohn; Sai V Seetharaman; Osman Bilsel; C Robert Matthews; Peter Hart; Joan Selverstone Valentine; Lawrence J Hayward
Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis.
The Journal of biological chemistry 2009;284(40):27746-58.
2009: Sai V Seetharaman; Mercedes Prudencio; Celeste Karch; Stephen P Holloway; David R Borchelt; Peter Hart
Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.
Experimental biology and medicine (Maywood, N.J.) 2009;234(10):1140-54.
2009: Sowmya Balasubramanian; Thirumalai R Kannan; Peter Hart; Joel Baseman
Amino acid changes in elongation factor Tu of Mycoplasma pneumoniae and Mycoplasma genitalium influence fibronectin binding.
Infection and immunity 2009;77(9):3533-41.
2009: Mercedes Prudencio; Peter Hart; David R Borchelt; Peter M Andersen
Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.
Human molecular genetics 2009;18(17):3217-26.
2009: Jeffry M Leitch; Laran T Jensen; Samantha D Bouldin; Caryn Outten; Peter Hart; Valeria Cizewski Culotta
Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS.
The Journal of biological chemistry 2009;284(33):21863-71.
2009: Celeste M Karch; Mercedes Prudencio; Duane D Winkler; Peter Hart; David R Borchelt
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):7774-9.
2009: Ding Chen; Jijie Chai; Peter Hart; Guangming Zhong
Identifying catalytic residues in CPAF, a Chlamydia-secreted protease.
Archives of biochemistry and biophysics 2009;485(1):16-23.
2009: Duane D Winkler; Jonathan P Schuermann; Xiaohang Cao; Stephen P Holloway; David R Borchelt; Mark C Carroll; Jody B Proescher; Valeria Cizewski Culotta; Peter Hart
Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q.
Biochemistry 2009;48(15):3436-47.
2008: Jonathan P Schuermann; Jianwen Jiang; Jorge Cuellar; Oscar Llorca; Liping Wang; Luis E Gimenez; Suping Jin; Alexander B Taylor; Borries Demeler; Kevin A Morano; Peter Hart; Jose M Valpuesta; Eileen M Lafer; Rui Sousa
Structure of the Hsp110:Hsc70 nucleotide exchange machine.
Molecular cell 2008;31(2):232-43.
2008: Xiaohang Cao; Svetlana Antonyuk; Sai V Seetharaman; Lisa J Whitson; Alexander B Taylor; Stephen P Holloway; Richard W Strange; Peter A Doucette; Joan Selverstone Valentine; Ashutosh Tiwari; Lawrence J Hayward; Shelby Padua; Jeffrey A Cohlberg; S Samar Hasnain; Peter Hart
Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis.
The Journal of biological chemistry 2008;283(23):16169-77.
2008: Alexander B Taylor; Gang Hu; Peter Hart; Lee McAlister-Henn
Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase.
The Journal of biological chemistry 2008;283(16):10872-80.
2008: Alexander B Taylor; Britta Meyer; Belinda Z Leal; Peter Kötter; Virgil Schirf; Borries Demeler; Peter Hart; Karl-Dieter Entian; Jens Wöhnert
The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.
Nucleic acids research 2008;36(5):1542-54.
2007: Liliana Quintanar; Christopher S Stoj; Alexander B Taylor; Peter Hart; Daniel J Kosman; Edward I Solomon
Shall we dance? How a multicopper oxidase chooses its electron transfer partner.
Accounts of chemical research 2007;40(6):445-52.
2007: Gang Hu; Alexander B Taylor; Lee McAlister-Henn; Peter Hart
Crystal structure of the yeast nicotinamidase Pnc1p.
Archives of biochemistry and biophysics 2007;461(1):66-75.
2007: Jiou Wang; Amy Caruano-Yzermans; Angela Rodriguez; Jonathan P Scheurmann; Hilda H Slunt; Xiaohang Cao; Jonathan D Gitlin; Peter Hart; David R Borchelt
Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability.
The Journal of biological chemistry 2007;282(1):345-52.
2006: Mark C Carroll; Caryn Outten; Jody B Proescher; Leah Rosenfeld; WALTER WATSON; Lisa J Whitson; Peter Hart; Laran T Jensen; Valeria Cizewski Culotta
The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase.
The Journal of biological chemistry 2006;281(39):28648-56.
2006: Lisa M Heitmann; Alexander B Taylor; Peter Hart; Adam R Urbach
Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.
Journal of the American Chemical Society 2006;128(38):12574-81.
2006: Peter Hart
Pathogenic superoxide dismutase structure, folding, aggregation and turnover.
Current opinion in chemical biology 2006;10(2):131-8.
2005: Luca Di Noto; Lisa J Whitson; Xiaohang Cao; Peter Hart; Rodney L Levine
Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis.
The Journal of biological chemistry 2005;280(48):39907-13.
2005: Alexander B Taylor; Christopher S Stoj; Lynn Ziegler; Daniel J Kosman; Peter Hart
The copper-iron connection in biology: structure of the metallo-oxidase Fet3p.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(43):15459-64.
2005: Gang Hu; Alexander B Taylor; Lee McAlister-Henn; Peter Hart
Crystallization and preliminary X-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 5):486-8.
2005: Svetlana Antonyuk; Jennifer Stine Elam; Michael A Hough; Richard W Strange; Peter A Doucette; Jorge A Rodriguez; Lawrence J Hayward; Joan Selverstone Valentine; Peter Hart; S Samar Hasnain
Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.
Protein science : a publication of the Protein Society 2005;14(5):1201-13.
2004: Peter A Doucette; Lisa J Whitson; Xiaohang Cao; Virgil Schirf; Borries Demeler; Joan Selverstone Valentine; Jeffrey C Hansen; Peter Hart
Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability.
The Journal of biological chemistry 2004;279(52):54558-66.
2004: Julie Laliberté; Lisa J Whitson; Jude Beaudoin; Stephen P Holloway; Peter Hart; Simon Labbé
The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways.
The Journal of biological chemistry 2004;279(27):28744-55.
2004: Michael A Hough; J Günter Grossmann; Svetlana Antonyuk; Richard W Strange; Peter A Doucette; Jorge A Rodriguez; Lisa J Whitson; Peter Hart; Lawrence J Hayward; Joan Selverstone Valentine; S Samar Hasnain
Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):5976-81.
2003: Alexander B Taylor; David M Benglis; Subramanian Dhandayuthapani; Peter Hart
Structure of Mycobacterium tuberculosis methionine sulfoxide reductase A in complex with protein-bound methionine.
Journal of bacteriology 2003;185(14):4119-26.
2003: Jennifer Stine Elam; Kevin Malek; Jorge A Rodriguez; Peter A Doucette; Alexander B Taylor; Lawrence J Hayward; Diane E Cabelli; Joan Selverstone Valentine; Peter Hart
An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate.
The Journal of biological chemistry 2003;278(23):21032-9.
2003: Jennifer Stine Elam; Alexander B Taylor; Richard Strange; Svetlana Antonyuk; Peter A Doucette; Jorge A Rodriguez; S Samar Hasnain; Lawrence J Hayward; Joan Selverstone Valentine; Todd O Yeates; Peter Hart
Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS.
Nature structural biology 2003;10(6):461-7.
2003: Jianwen Jiang; Alexander B Taylor; Kondury Prasad; Yumiko Ishikawa-Brush; Peter Hart; Eileen M Lafer; Rui Sousa
Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface.
Biochemistry 2003;42(19):5748-53.
2003: Richard W Strange; Svetlana Antonyuk; Michael A Hough; Peter A Doucette; Jorge A Rodriguez; Peter Hart; Lawrence J Hayward; Joan Selverstone Valentine; S Samar Hasnain
The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.
Journal of molecular biology 2003;328(4):877-91.
2003: Joan Selverstone Valentine; Peter Hart
Misfolded CuZnSOD and amyotrophic lateral sclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3617-22.
2002: John Pascal; Peter Hart; Norman B Hecht; Jon D Robertus
Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.
Journal of molecular biology 2002;319(5):1049-57.
2002: Peter Hart; Shashank Deep; Alexander B Taylor; Zhanyong Shu; Cynthia S Hinck; Andrew Hinck
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex.
Nature structural biology 2002;9(3):203-8.
2002: Jennifer Stine Elam; Susan T Thomas; Stephen P Holloway; Alexander B Taylor; Peter Hart
Copper chaperones.
Advances in protein chemistry 2002;60():151-219.
2000: Haining Zhu; Eric L Shipp; Raylene J Sanchez; A Liba; J E Stine; Peter Hart; Edith Butler Gralla; Aram M Nersissian; Joan Selverstone Valentine
Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism.
Biochemistry 2000;39(18):5413-21.
2000: L T Hall; Raylene J Sanchez; Stephen P Holloway; Haining Zhu; J E Stine; T J Lyons; Borries Demeler; Virgil Schirf; Jeffrey C Hansen; Aram M Nersissian; Joan Selverstone Valentine; Peter Hart
X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery.
Biochemistry 2000;39(13):3611-23.
1999: Peter Hart; Melinda Balbirnie; Nancy L Ogihara; Aram M Nersissian; M S Weiss; Joan Selverstone Valentine; David Eisenberg
A structure-based mechanism for copper-zinc superoxide dismutase.
Biochemistry 1999;38(7):2167-78.
1999: Joan Selverstone Valentine; Peter Hart; Edith Butler Gralla
Copper-zinc superoxide dismutase and ALS.
Advances in experimental medicine and biology 1999;448():193-203.
1998: Jon D Robertus; Arthur F Monzingo; E M Marcotte; Peter Hart
Structural analysis shows five glycohydrolase families diverged from a common ancestor.
The Journal of experimental zoology 1998;282(1-2):127-32.
1998: Aram M Nersissian; C Immoos; M G Hill; Peter Hart; G Williams; R G Herrmann; Joan Selverstone Valentine
Uclacyanins, stellacyanins, and plantacyanins are distinct subfamilies of phytocyanins: plant-specific mononuclear blue copper proteins.
Protein science : a publication of the Protein Society 1998;7(9):1915-29.
1998: Yanshun Liu; Peter Hart; M P Schlunegger; David Eisenberg
The crystal structure of a 3D domain-swapped dimer of RNase A at a 2.1-A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3437-42.
1998: Peter Hart; H Liu; M Pellegrini; Aram M Nersissian; Edith Butler Gralla; Joan Selverstone Valentine; David Eisenberg
Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis.
Protein science : a publication of the Protein Society 1998;7(3):545-55.
1997: Dale E Bredesen; Lisa M Ellerby; Peter Hart; Martina Wiedau-Pazos; J S Valentine
Do posttranslational modifications of CuZnSOD lead to sporadic amyotrophic lateral sclerosis?
Annals of neurology 1997;42(2):135-7.
1996: Aram M Nersissian; Z B Mehrabian; R M Nalbandyan; Peter Hart; G Fraczkiewicz; R S Czernuszewicz; C J Bender; Jack Peisach; R G Herrmann; Joan Selverstone Valentine
Cloning, expression, and spectroscopic characterization of Cucumis sativus stellacyanin in its nonglycosylated form.
Protein science : a publication of the Protein Society 1996;5(11):2184-92.
1996: Peter Hart; Aram M Nersissian; R G Herrmann; R M Nalbandyan; Joan Selverstone Valentine; David Eisenberg
A missing link in cupredoxins: crystal structure of cucumber stellacyanin at 1.6 A resolution.
Protein science : a publication of the Protein Society 1996;5(11):2175-83.
1996: Nancy L Ogihara; H E Parge; Peter Hart; M S Weiss; J J Goto; B R Crane; J Tsang; K Slater; J A Roe; Joan Selverstone Valentine; David Eisenberg; J A Tainer
Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase.
Biochemistry 1996;35(7):2316-21.
1996: Arthur F Monzingo; E M Marcotte; Peter Hart; Jon D Robertus
Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic families sharing a conserved core.
Nature structural biology 1996;3(2):133-40.
1995: Peter Hart; H D Pfluger; Arthur F Monzingo; Thomas Hollis; Jon D Robertus
The refined crystal structure of an endochitinase from Hordeum vulgare L. seeds at 1.8 A resolution.
Journal of molecular biology 1995;248(2):402-13.
1993: E Marcotte; Peter Hart; I Boucher; Ryszard Brzezinski; Jon D Robertus
Crystallization of a chitosanase from Streptomyces N174.
Journal of molecular biology 1993;232(3):995-6.
1993: Peter Hart; Arthur F Monzingo; M P Ready; SR Ernst; Jon D Robertus
Crystal structure of an endochitinase from Hordeum vulgare L. seeds.
Journal of molecular biology 1993;229(1):189-93.
1992: Peter Hart; M P Ready; Jon D Robertus
Crystallization of an endochitinase from Hordeum vulgar L. seeds.
Journal of molecular biology 1992;225(2):565-7.
1991: Peter Hart; Arthur F Monzingo; Arthur Donohue-Rolfe; G T Keusch; Stephen B Calderwood; Jon D Robertus
Crystallization of the B chain of Shiga-like toxin I from Escherichia coli.
Journal of molecular biology 1991;218(4):691-4.