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philippe froguel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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France

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Publications

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Bonnefond Amélie; Vaxillaire Martine; Labrune Yann; Lecoeur Cécile; Chèvre Jean-Claude; Bouatia-Naji Nabila; Cauchi Stéphane; Balkau Beverley; Marre Michel; Tichet Jean; Riveline Jean-Pierre; Hadjadj Samy; Gallois Yves; Czernichow Sébastien; Hercberg Serge; Kaakinen Marika; Wiesner Susanne; Charpentier Guillaume; Lévy-Marchal Claire; Elliott Paul; Jarvelin Marjo-Riitta; Horber Fritz; Dina Christian; Pedersen Oluf; Sladek Robert; Meyre David; Froguel Philippe
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
Chambers John C; Zhang Weihua; Zabaneh Delilah; Sehmi Joban; Jain Piyush; McCarthy Mark I; Froguel Philippe; Ruokonen Aimo; Balding David; Jarvelin Marjo-Riitta; Scott James; Elliott Paul; Kooner Jaspal S
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.
Le Clerc Sigrid; Limou Sophie; Coulonges Cédric; Carpentier Wassila; Dina Christian; Taing Lieng; Delaneau Olivier; Labib Taoufik; Sladek Rob; Deveau Christiane; Guillemain Hélène; Ratsimandresy Rojo; Montes Matthieu; Spadoni Jean-Louis; Therwath Amu; Schächter François; Matsuda Fumihiko; Gut Ivo; Lelièvre Jean-Daniel; Lévy Yves; Froguel Philippe; Delfraissy Jean-François; Hercberg Serge; Zagury Jean-François
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

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All Publications

2009: Bonnefond Amélie; Vaxillaire Martine; Labrune Yann; Lecoeur Cécile; Chèvre Jean-Claude; Bouatia-Naji Nabila; Cauchi Stéphane; Balkau Beverley; Marre Michel; Tichet Jean; Riveline Jean-Pierre; Hadjadj Samy; Gallois Yves; Czernichow Sébastien; Hercberg Serge; Kaakinen Marika; Wiesner Susanne; Charpentier Guillaume; Lévy-Marchal Claire; Elliott Paul; Jarvelin Marjo-Riitta; Horber Fritz; Dina Christian; Pedersen Oluf; Sladek Robert; Meyre David; Froguel Philippe
Genetic variant in HK1 is associated with a proanemic state and A1C but not other glycemic control-related traits.
Diabetes 2009;58(11):2687-97.
2009: Chambers John C; Zhang Weihua; Zabaneh Delilah; Sehmi Joban; Jain Piyush; McCarthy Mark I; Froguel Philippe; Ruokonen Aimo; Balding David; Jarvelin Marjo-Riitta; Scott James; Elliott Paul; Kooner Jaspal S
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.
Diabetes 2009;58(11):2703-8.
2009: Le Clerc Sigrid; Limou Sophie; Coulonges Cédric; Carpentier Wassila; Dina Christian; Taing Lieng; Delaneau Olivier; Labib Taoufik; Sladek Rob; Deveau Christiane; Guillemain Hélène; Ratsimandresy Rojo; Montes Matthieu; Spadoni Jean-Louis; Therwath Amu; Schächter François; Matsuda Fumihiko; Gut Ivo; Lelièvre Jean-Daniel; Lévy Yves; Froguel Philippe; Delfraissy Jean-François; Hercberg Serge; Zagury Jean-François
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
The Journal of infectious diseases 2009;200(8):1194-201.
2009: Rung Johan; Cauchi Stéphane; Albrechtsen Anders; Shen Lishuang; Rocheleau Ghislain; Cavalcanti-Proença Christine; Bacot François; Balkau Beverley; Belisle Alexandre; Borch-Johnsen Knut; Charpentier Guillaume; Dina Christian; Durand Emmanuelle; Elliott Paul; Hadjadj Samy; Järvelin Marjo-Riitta; Laitinen Jaana; Lauritzen Torsten; Marre Michel; Mazur Alexander; Meyre David; Montpetit Alexandre; Pisinger Charlotta; Posner Barry; Poulsen Pernille; Pouta Anneli; Prentki Marc; Ribel-Madsen Rasmus; Ruokonen Aimo; Sandbaek Anelli; Serre David; Tichet Jean; Vaxillaire Martine; Wojtaszewski Jørgen F P; Vaag Allan; Hansen Torben; Polychronakos Constantin; Pedersen Oluf; Froguel Philippe; Sladek Robert
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Nature genetics 2009;41(10):1110-5.
2009: Saiki Atsuhito; Olsson Maja; Jernås Margareta; Gummesson Anders; McTernan Philip G; Andersson Johanna; Jacobson Peter; Sjöholm Kajsa; Olsson Bob; Yamamura Shigeo; Walley Andrew; Froguel Philippe; Carlsson Björn; Sjöström Lars; Svensson Per-Arne; Carlsson Lena M S
Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.
The Journal of clinical endocrinology and metabolism 2009;94(10):3987-94.
2009: Kamal Maud; Marquez Marcel; Vauthier Virginie; Leloire Audrey; Froguel Philippe; Jockers Ralf; Couturier Cyril
Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors.
Biotechnology journal 2009;4(9):1337-44.
2009: de Smith Adam J; Purmann Carolin; Walters Robin G; Ellis Richard J; Holder Susan E; Van Haelst Mieke M; Brady Angela F; Fairbrother Una L; Dattani Mehul; Keogh Julia M; Henning Elana; Yeo Giles S H; O'Rahilly Stephen; Froguel Philippe; Farooqi I Sadaf; Blakemore Alexandra I F
A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism.
Human molecular genetics 2009;18(17):3257-65.
2009: Garcia Edwin A; King Peter; Sidhu Kally; Ohgusu Hideko; Walley Andrew; Lecoeur Cecile; Gueorguiev Maria; Khalaf Sahira; Davies Derek; Grossman Ashley B; Kojima Masayasu; Petersenn Stephan; Froguel Phillipe; Korbonits Márta
The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes.
European journal of endocrinology / European Federation of Endocrine Societies 2009;161(2):307-15.
2009: Blakemore Alexandra I F; Meyre David; Delplanque Jerome; Vatin Vincent; Lecoeur Cecile; Marre Michel; Tichet Jean; Balkau Beverley; Froguel Philippe; Walley Andrew J
A rare variant in the visfatin gene (NAMPT/PBEF1) is associated with protection from obesity.
Obesity (Silver Spring, Md.) 2009;17(8):1549-53.
2009: Elliott Paul; Chambers John C; Zhang Weihua; Clarke Robert; Hopewell Jemma C; Peden John F; Erdmann Jeanette; Braund Peter; Engert James C; Bennett Derrick; Coin Lachlan; Ashby Deborah; Tzoulaki Ioanna; Brown Ian J; Mt-Isa Shahrul; McCarthy Mark I; Peltonen Leena; Freimer Nelson B; Farrall Martin; Ruokonen Aimo; Hamsten Anders; Lim Noha; Froguel Philippe; Waterworth Dawn M; Vollenweider Peter; Waeber Gerard; Jarvelin Marjo-Riitta; Mooser Vincent; Scott James; Hall Alistair S; Schunkert Heribert; Anand Sonia S; Collins Rory; Samani Nilesh J; Watkins Hugh; Kooner Jaspal S
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
JAMA : the journal of the American Medical Association 2009;302(1):37-48.
2009: Boissel Sarah; Reish Orit; Proulx Karine; Kawagoe-Takaki Hiroko; Sedgwick Barbara; Yeo Giles S H; Meyre David; Golzio Christelle; Molinari Florence; Kadhom Noman; Etchevers Heather C; Saudek Vladimir; Farooqi I Sadaf; Froguel Philippe; Lindahl Tomas; O'Rahilly Stephen; Munnich Arnold; Colleaux Laurence
Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations.
American journal of human genetics 2009;85(1):106-11.
2009: Walley Andrew J; Asher Julian E; Froguel Philippe
The genetic contribution to non-syndromic human obesity.
Nature reviews. Genetics 2009;10(7):431-42.
2009: Traurig Michael; Mack Janel; Hanson Robert L; Ghoussaini Maya; Meyre David; Knowler William C; Kobes Sayuko; Froguel Philippe; Bogardus Clifton; Baier Leslie J
Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
Diabetes 2009;58(7):1682-9.
2009: Prokopenko Inga; Zeggini Eleftheria; Hanson Robert L; Mitchell Braxton D; Rayner N William; Akan Pelin; Baier Leslie; Das Swapan K; Elliott Katherine S; Fu Mao; Frayling Timothy M; Groves Christopher J; Gwilliam Rhian; Scott Laura J; Voight Benjamin F; Hattersley Andrew T; Hu Cheng; Morris Andrew D; Ng Maggie; Palmer Colin N A; Tello-Ruiz Marcela; Vaxillaire Martine; Wang Cong-Rong; Stein Lincoln; Chan Juliana; Jia Weiping; Froguel Philippe; Elbein Steven C; Deloukas Panos; Bogardus Clifton; Shuldiner Alan R; McCarthy Mark I;
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
Diabetes 2009;58(7):1704-9.
2009: Choquet Hélène; Cavalcanti-Proença Christine; Lecoeur Cécile; Dina Christian; Cauchi Stéphane; Vaxillaire Martine; Hadjadj Samy; Horber Fritz; Potoczna Natasha; Charpentier Guillaume; Ruiz Juan; Hercberg Serge; Maimaitiming Suliya; Roussel Ronan; Boenhnke Michael; Jackson Anne U; Patsch Wolfgang; Krempler Franz; Voight Benjamin F; Altshuler David; Groop Leif; Thorleifsson Gudmar; Steinthorsdottir Valgerdur; Stefansson Kari; Balkau Beverley; Froguel Philippe; Meyre David
The T-381C SNP in BNP gene may be modestly associated with type 2 diabetes: an updated meta-analysis in 49 279 subjects.
Human molecular genetics 2009;18(13):2495-501.
2009: Goossens G H; Petersen L; Blaak E E; Hul G; Arner P; Astrup A; Froguel P; Patel K; Pedersen O; Polak J; Oppert J-M; Martinez J A; Sørensen T I A; Saris W H M;
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
International journal of obesity (2005) 2009;33(6):669-79.
2009: Sparsø Thomas; Bonnefond Amélie; Andersson Ehm; Bouatia-Naji Nabila; Holmkvist Johan; Wegner Lise; Grarup Niels; Gjesing Anette P; Banasik Karina; Cavalcanti-Proença Christine; Marchand Marion; Vaxillaire Martine; Charpentier Guillaume; Jarvelin Marjo-Riitta; Tichet Jean; Balkau Beverley; Marre Michel; Lévy-Marchal Claire; Faerch Kristine; Borch-Johnsen Knut; Jørgensen Torben; Madsbad Sten; Poulsen Pernille; Vaag Allan; Dina Christian; Hansen Torben; Pedersen Oluf; Froguel Philippe
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
Diabetes 2009;58(6):1450-6.
2009: Jernås Margareta; Olsson Bob; Arner Peter; Jacobson Peter; Sjöström Lars; Walley Andrew; Froguel Philippe; McTernan Philip G; Hoffstedt Johan; Carlsson Lena M S
Regulation of carboxylesterase 1 (CES1) in human adipose tissue.
Biochemical and biophysical research communications 2009;383(1):63-7.
2009: Carlsson Lena M S; Jacobson Peter; Walley Andrew; Froguel Philippe; Sjöström Lars; Svensson Per-Arne; Sjöholm Kajsa
ALK7 expression is specific for adipose tissue, reduced in obesity and correlates to factors implicated in metabolic disease.
Biochemical and biophysical research communications 2009;382(2):309-14.
2009: Cauchi Stéphane; Stutzmann Fanny; Cavalcanti-Proença Christine; Durand Emmanuelle; Pouta Anneli; Hartikainen Anna-Liisa; Marre Michel; Vol Sylviane; Tammelin Tuija; Laitinen Jaana; Gonzalez-Izquierdo Arturo; Blakemore Alexandra I F; Elliott Paul; Meyre David; Balkau Beverley; Järvelin Marjo-Riitta; Froguel Philippe
Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.
Journal of molecular medicine (Berlin, Germany) 2009;87(5):537-46.
2009: Bonnefond A; Bouatia-Naji N; Simon A; Saint-Martin C; Dechaume A; de Lonlay P; Polak M; Bellanné-Chantelot C; Froguel P; Vaxillaire M
Mutations in G6PC2 do not contribute to monogenic forms of early infancy diabetes and beta cell dysfunction.
Diabetologia 2009;52(5):982-5.
2009: Bossé Yohan; Bacot François; Montpetit Alexandre; Rung Johan; Qu Hui-Qi; Engert James C; Polychronakos Constantin; Hudson Thomas J; Froguel Philippe; Sladek Robert; Desrosiers Martin
Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.
Human genetics 2009;125(3):305-18.
2009: Gueorguiev Maria; Lecoeur Cécile; Meyre David; Benzinou Michael; Mein Charles A; Hinney Anke; Vatin Vincent; Weill Jacques; Heude Barbara; Hebebrand Johannes; Grossman Ashley B; Korbonits Márta; Froguel Philippe
Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.
Obesity (Silver Spring, Md.) 2009;17(4):745-54.
2009: Bouatia-Naji Nabila; Marchand Marion; Cavalcanti-Proença Christine; Daghmoun Samia; Durand Emmanuelle; Tichet Jean; Marre Michel; Balkau Beverley; Froguel Philippe; Lévy-Marchal Claire
Smallness for gestational age interacts with high mobility group A2 gene genetic variation to modulate height.
European journal of endocrinology / European Federation of Endocrine Societies 2009;160(4):557-60.
2009: Vaxillaire Martine; D Pharm; Bonnefond Amélie; Froguel Philippe
Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes.
Pediatric endocrinology reviews : PER 2009;6(3):405-17.
2009: Stutzmann F; Cauchi S; Durand E; Calvacanti-Proença C; Pigeyre M; Hartikainen A-L; Sovio U; Tichet J; Marre M; Weill J; Balkau B; Potoczna N; Laitinen J; Elliott P; Järvelin M-R; Horber F; Meyre D; Froguel P
Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.
International journal of obesity (2005) 2009;33(3):373-8.
2009: Meyre David; Delplanque Jérôme; Chèvre Jean-Claude; Lecoeur Cécile; Lobbens Stéphane; Gallina Sophie; Durand Emmanuelle; Vatin Vincent; Degraeve Franck; Proença Christine; Gaget Stefan; Körner Antje; Kovacs Peter; Kiess Wieland; Tichet Jean; Marre Michel; Hartikainen Anna-Liisa; Horber Fritz; Potoczna Natascha; Hercberg Serge; Levy-Marchal Claire; Pattou François; Heude Barbara; Tauber Maithé; McCarthy Mark I; Blakemore Alexandra I F; Montpetit Alexandre; Polychronakos Constantin; Weill Jacques; Coin Lachlan J M; Asher Julian; Elliott Paul; Järvelin Marjo-Riitta; Visvikis-Siest Sophie; Balkau Beverley; Sladek Rob; Balding David; Walley Andrew; Dina Christian; Froguel Philippe
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
Nature genetics 2009;41(2):157-9.
2009: Limou Sophie; Le Clerc Sigrid; Coulonges Cédric; Carpentier Wassila; Dina Christian; Delaneau Olivier; Labib Taoufik; Taing Lieng; Sladek Rob; Deveau Christiane; Ratsimandresy Rojo; Montes Matthieu; Spadoni Jean-Louis; Lelièvre Jean-Daniel; Lévy Yves; Therwath Amu; Schächter François; Matsuda Fumihiko; Gut Ivo; Froguel Philippe; Delfraissy Jean-François; Hercberg Serge; Zagury Jean-François;
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
The Journal of infectious diseases 2009;199(3):419-26.
2009: El Achhab Y; Meyre D; Bouatia-Naji N; Berraho M; Deweirder M; Vatin V; Delplanque J; Serhier Z; Lyoussi B; Nejjari C; Froguel P; Chikri M
Association of the ENPP1 K121Q polymorphism with type 2 diabetes and obesity in the Moroccan population.
Diabetes & metabolism 2009;35(1):37-42.
2009: Bouatia-Naji Nabila; Bonnefond Amélie; Cavalcanti-Proença Christine; Sparsø Thomas; Holmkvist Johan; Marchand Marion; Delplanque Jérôme; Lobbens Stéphane; Rocheleau Ghislain; Durand Emmanuelle; De Graeve Franck; Chèvre Jean-Claude; Borch-Johnsen Knut; Hartikainen Anna-Liisa; Ruokonen Aimo; Tichet Jean; Marre Michel; Weill Jacques; Heude Barbara; Tauber Maithé; Lemaire Katleen; Schuit Frans; Elliott Paul; Jørgensen Torben; Charpentier Guillaume; Hadjadj Samy; Cauchi Stéphane; Vaxillaire Martine; Sladek Robert; Visvikis-Siest Sophie; Balkau Beverley; Lévy-Marchal Claire; Pattou François; Meyre David; Blakemore Alexandra I F; Jarvelin Marjo-Riita; Walley Andrew J; Hansen Torben; Dina Christian; Pedersen Oluf; Froguel Philippe
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
Nature genetics 2009;41(1):89-94.
2009: Morandi Anita; Pinelli Leonardo; Petrone Antonio; Vatin Vincent; Buzzetti Raffaella; Froguel Philippe; Meyre David
The Q121 variant of ENPP1 may protect from childhood overweight/obesity in the Italian population.
Obesity (Silver Spring, Md.) 2009;17(1):202-6.
2009: Gueorguiev M; Lecoeur C; Benzinou M; Mein C A; Meyre D; Vatin V; Weill J; Heude B; Grossman A B; Froguel P; Korbonits M
A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature.
Annals of human genetics 2009;73(1):1-9.
2009: Ezzidi Intissar; Mtiraoui Nabil; Cauchi Stéphane; Vaillant Emmanuel; Dechaume Aurélie; Chaieb Molka; Kacem Maha; Almawi Wassim Y; Froguel Philippe; Mahjoub Touhami; Vaxillaire Martine
Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
BMC medical genetics 2009;10():33.
2009: Dahlman Ingrid; Nilsson Maria; Gu Harvest F; Lecoeur Cecile; Efendic Suad; Ostenson Claes G; Brismar Kerstin; Gustafsson Jan-Ake; Froguel Philippe; Vaxillaire Martine; Dahlman-Wright Karin; Steffensen Knut R
Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.
BMC medical genetics 2009;10():27.
2009: Duesing Konsta; Charpentier Guillaume; Marre Michel; Tichet Jean; Hercberg Serge; Balkau Beverley; Froguel Philippe; Gibson Fernando
Evaluating the association of common APOA2 variants with type 2 diabetes.
BMC medical genetics 2009;10():13.
2008: Blakemore Alexandra I F; Froguel Philippe
Is obesity our genetic legacy?
The Journal of clinical endocrinology and metabolism 2008;93(11 Suppl 1):S51-6.
2008: Dahlman Ingrid; Vaxillaire Martine; Nilsson Maria; Lecoeur Cecile; Gu Harvest F; Cavalcanti-Proença Christine; Efendic Suad; Ostenson Claes G; Brismar Kerstin; Charpentier Guillaume; Gustafsson Jan-Ake; Froguel Philippe; Dahlman-Wright Karin; Steffensen Knut R
Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose.
Pharmacogenetics and genomics 2008;18(11):967-75.
2008: Villalobos-Comparán Marisela; Teresa Flores-Dorantes M; Teresa Villarreal-Molina M; Rodríguez-Cruz Maricela; García-Ulloa Ana C; Robles Lorena; Huertas-Vázquez Adriana; Saucedo-Villarreal Nubia; López-Alarcón Mardia; Sánchez-Muñoz Fausto; Domínguez-López Aarón; Gutiérrez-Aguilar Ruth; Menjivar Marta; Coral-Vázquez Ramón; Hernández-Stengele Gabriel; Vital-Reyes Victor S; Acuña-Alonzo Victor; Romero-Hidalgo Sandra; Ruiz-Gómez Doris G; Riaño-Barros Daniela; Herrera Miguel F; Gómez-Pérez Francisco J; Froguel Philippe; García-García Eduardo; Teresa Tusié-Luna M; Aguilar-Salinas Carlos A; Canizales-Quinteros Samuel
The FTO gene is associated with adulthood obesity in the Mexican population.
Obesity (Silver Spring, Md.) 2008;16(10):2296-301.
2008: Balkau Beverley; Lange Céline; Fezeu Leopold; Tichet Jean; de Lauzon-Guillain Blandine; Czernichow Sebastien; Fumeron Frederic; Froguel Philippe; Vaxillaire Martine; Cauchi Stephane; Ducimetière Pierre; Eschwège Eveline
Predicting diabetes: clinical, biological, and genetic approaches: data from the Epidemiological Study on the Insulin Resistance Syndrome (DESIR).
Diabetes care 2008;31(10):2056-61.
2008: Bouhaha R; Meyre D; Kamoun H Abid; Ennafaa H; Vaillant E; Sassi R; Baroudi T; Vatin V; Froguel P; Elgaaied A; Vaxillaire M
Effect of ENPP1/PC-1-K121Q and PPARgamma-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population.
Diabetes research and clinical practice 2008;81(3):278-83.
2008: Stutzmann Fanny; Tan Karen; Vatin Vincent; Dina Christian; Jouret Béatrice; Tichet Jean; Balkau Beverley; Potoczna Natascha; Horber Fritz; O'Rahilly Stephen; Farooqi I Sadaf; Froguel Philippe; Meyre David
Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.
Diabetes 2008;57(9):2511-8.
2008: Wermter Anne-Kathrin; Scherag André; Meyre David; Reichwald Kathrin; Durand Emmanuelle; Nguyen Thuy Trang; Koberwitz Kerstin; Lichtner Peter; Meitinger Thomas; Schäfer Helmut; Hinney Anke; Froguel Philippe; Hebebrand Johannes; Brönner Günter
Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans.
European journal of human genetics : EJHG 2008;16(9):1126-34.
2008: Froguel Philippe; Blakemore Alexandra I F
The power of the extreme in elucidating obesity.
The New England journal of medicine 2008;359(9):891-3.
2008: Benzinou Michael; Creemers John W M; Choquet Helene; Lobbens Stephane; Dina Christian; Durand Emmanuelle; Guerardel Audrey; Boutin Philippe; Jouret Beatrice; Heude Barbara; Balkau Beverley; Tichet Jean; Marre Michel; Potoczna Natascha; Horber Fritz; Le Stunff Catherine; Czernichow Sebastien; Sandbaek Annelli; Lauritzen Torsten; Borch-Johnsen Knut; Andersen Gitte; Kiess Wieland; Körner Antje; Kovacs Peter; Jacobson Peter; Carlsson Lena M S; Walley Andrew J; Jørgensen Torben; Hansen Torben; Pedersen Oluf; Meyre David; Froguel Philippe
Common nonsynonymous variants in PCSK1 confer risk of obesity.
Nature genetics 2008;40(8):943-5.
2008: Vaxillaire Martine; Cavalcanti-Proença Christine; Dechaume Aurélie; Tichet Jean; Marre Michel; Balkau Beverley; Froguel Philippe;
The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.
Diabetes 2008;57(8):2253-7.
2008: Gutiérrez-Aguilar Ruth; Froguel Philippe; Hamid Yasmin H; Benmezroua Yamina; Jørgensen Torben; Borch-Johnsen Knut; Hansen Torben; Pedersen Oluf; Neve Bernadette
Genetic analysis of Kruppel-like zinc finger 11 variants in 5864 Danish individuals: potential effect on insulin resistance and modified signal transducer and activator of transcription-3 binding by promoter variant -1659G>C.
The Journal of clinical endocrinology and metabolism 2008;93(8):3128-35.
2008: Poulain-Godefroy Odile; Lecoeur Cécile; Pattou François; Frühbeck Gema; Froguel Philippe
Inflammation is associated with a decrease of lipogenic factors in omental fat in women.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(1):R1-7.
2008: Duesing Konsta; Fatemifar Ghazaleh; Charpentier Guillaume; Marre Michel; Tichet Jean; Hercberg Serge; Balkau Beverley; Froguel Philippe; Gibson Fernando
Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians.
Diabetes 2008;57(7):1992-6.
2008: Martin Delphine; Bellanné-Chantelot Christine; Deschamps Inge; Froguel Philippe; Robert Jean-Jacques; Velho Gilberto
Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).
Diabetes care 2008;31(7):1321-3.
2008: Benzinou Michael; Chèvre Jean-Claude; Ward Kirsten J; Lecoeur Cécile; Dina Christian; Lobbens Stephane; Durand Emmanuelle; Delplanque Jérome; Horber Fritz F; Heude Barbara; Balkau Beverley; Borch-Johnsen Knut; Jørgensen Torben; Hansen Torben; Pedersen Oluf; Meyre David; Froguel Philippe
Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.
Human molecular genetics 2008;17(13):1916-21.
2008: Loos Ruth J F; Lindgren Cecilia M; Li Shengxu; Wheeler Eleanor; Zhao Jing Hua; Prokopenko Inga; Inouye Michael; Freathy Rachel M; Attwood Antony P; Beckmann Jacques S; Berndt Sonja I; Jacobs Kevin B; Chanock Stephen J; Hayes Richard B; Bergmann Sven; Bennett Amanda J; Bingham Sheila A; Bochud Murielle; Brown Morris; Cauchi Stéphane; Connell John M; Cooper Cyrus; Smith George Davey; Day Ian; Dina Christian; De Subhajyoti; Dermitzakis Emmanouil T; Doney Alex S F; Elliott Katherine S; Elliott Paul; Evans David M; Sadaf Farooqi I; Froguel Philippe; Ghori Jilur; Groves Christopher J; Gwilliam Rhian; Hadley David; Hall Alistair S; Hattersley Andrew T; Hebebrand Johannes; Heid Iris M; Lamina Claudia; Gieger Christian; Illig Thomas; Meitinger Thomas; Wichmann H-Erich; Herrera Blanca; Hinney Anke; Hunt Sarah E; Jarvelin Marjo-Riitta; Johnson Toby; Jolley Jennifer D M; Karpe Fredrik; Keniry Andrew; Khaw Kay-Tee; Luben Robert N; Mangino Massimo; Marchini Jonathan; McArdle Wendy L; McGinnis Ralph; Meyre David; Munroe Patricia B; Morris Andrew D; Ness Andrew R; Neville Matthew J; Nica Alexandra C; Ong Ken K; O'Rahilly Stephen; Owen Katharine R; Palmer Colin N A; Papadakis Konstantinos; Potter Simon; Pouta Anneli; Qi Lu; Randall Joshua C; Rayner Nigel W; Ring Susan M; Sandhu Manjinder S; Scherag André; Sims Matthew A; Song Kijoung; Soranzo Nicole; Speliotes Elizabeth K; Syddall Holly E; Teichmann Sarah A; Timpson Nicholas J; Tobias Jonathan H; Uda Manuela; Vogel Carla I Ganz; Wallace Chris; Waterworth Dawn M; Weedon Michael N; Willer Cristen J; Wraight; Yuan Xin; Zeggini Eleftheria; Hirschhorn Joel N; Strachan David P; Ouwehand Willem H; Caulfield Mark J; Samani Nilesh J; Frayling Timothy M; Vollenweider Peter; Waeber Gerard; Mooser Vincent; Deloukas Panos; McCarthy Mark I; Wareham Nicholas J; Barroso Inês; Jacobs Kevin B; Chanock Stephen J; Hayes Richard B; Lamina Claudia; Gieger Christian; Illig Thomas; Meitinger Thomas; Wichmann H-Erich; Kraft Peter; Hankinson Susan E; Hunter David J; Hu Frank B; Lyon Helen N; Voight Benjamin F; Ridderstrale Martin; Groop Leif; Scheet Paul; Sanna Serena; Abecasis Goncalo R; Albai Giuseppe; Nagaraja Ramaiah; Schlessinger David; Jackson Anne U; Tuomilehto Jaakko; Collins Francis S; Boehnke Michael; Mohlke Karen L
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nature genetics 2008;40(6):768-75.
2008: Chambers John C; Elliott Paul; Zabaneh Delilah; Zhang Weihua; Li Yun; Froguel Philippe; Balding David; Scott James; Kooner Jaspal S
Common genetic variation near MC4R is associated with waist circumference and insulin resistance.
Nature genetics 2008;40(6):716-8.
2008: Bouatia-Naji Nabila; De Graeve Franck; Brönner Günter; Lecoeur Cécile; Vatin Vincent; Durand Emmanuelle; Lichtner Peter; Nguyen Thuy T; Heude Barbara; Weill Jacques; Lévy-Marchal Claire; Hebebrand Johannes; Froguel Philippe; Meyre David
INS VNTR is not associated with childhood obesity in 1,023 families: a family-based study.
Obesity (Silver Spring, Md.) 2008;16(6):1471-5.
2008: Tarasov Andrei I; Nicolson Tamara J; Riveline Jean-Pierre; Taneja Tarvinder K; Baldwin Stephen A; Baldwin Jocelyn M; Charpentier Guillaume; Gautier Jean-François; Froguel Philippe; Vaxillaire Martine; Rutter Guy A
A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults.
Diabetes 2008;57(6):1595-604.
2008: Liu Yong-Jun; Liu Xiao-Gang; Wang Liang; Dina Christian; Yan Han; Liu Jian-Feng; Levy Shawn; Papasian Christopher J; Drees Betty M; Hamilton James J; Meyre David; Delplanque Jerome; Pei Yu-Fang; Zhang Lei; Recker Robert R; Froguel Philippe; Deng Hong-Wen
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
Human molecular genetics 2008;17(12):1803-13.
2008: Meyre David; Farge Morgane; Lecoeur Cécile; Proenca Christine; Durand Emmanuelle; Allegaert Frédéric; Tichet Jean; Marre Michel; Balkau Beverley; Weill Jacques; Delplanque Jérôme; Froguel Philippe
R125W coding variant in TBC1D1 confers risk for familial obesity and contributes to linkage on chromosome 4p14 in the French population.
Human molecular genetics 2008;17(12):1798-802.
2008: Bouatia-Naji Nabila; Rocheleau Ghislain; Van Lommel Leentje; Lemaire Katleen; Schuit Frans; Cavalcanti-Proença Christine; Marchand Marion; Hartikainen Anna-Liisa; Sovio Ulla; De Graeve Franck; Rung Johan; Vaxillaire Martine; Tichet Jean; Marre Michel; Balkau Beverley; Weill Jacques; Elliott Paul; Jarvelin Marjo-Riitta; Meyre David; Polychronakos Constantin; Dina Christian; Sladek Robert; Froguel Philippe
A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.
Science (New York, N.Y.) 2008;320(5879):1085-8.
2008: Vaxillaire Martine; Froguel Philippe
Monogenic diabetes in the young, pharmacogenetics and relevance to multifactorial forms of type 2 diabetes.
Endocrine reviews 2008;29(3):254-64.
2008: Duesing K; Fatemifar G; Charpentier G; Marre M; Tichet J; Hercberg S; Balkau B; Froguel P; Gibson F
Strong association of common variants in the CDKN2A/CDKN2B region with type 2 diabetes in French Europids.
Diabetologia 2008;51(5):821-6.
2008: Cauchi Stéphane; Froguel Philippe
TCF7L2 genetic defect and type 2 diabetes.
Current diabetes reports 2008;8(2):149-55.
2008: Polak Michel; Dechaume Aurélie; Cavé Hélène; Nimri Revital; Crosnier Hélène; Sulmont Véronique; de Kerdanet Marc; Scharfmann Raphael; Lebenthal Yael; Froguel Philippe; Vaxillaire Martine;
Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group.
Diabetes 2008;57(4):1115-9.
2008: Cauchi Stéphane; Proença Christine; Choquet Hélène; Gaget Stefan; De Graeve Franck; Marre Michel; Balkau Beverley; Tichet Jean; Meyre David; Vaxillaire Martine; Froguel Philippe;
Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
Journal of molecular medicine (Berlin, Germany) 2008;86(3):341-8.
2008: Franks P W; Rolandsson O; Debenham S L; Fawcett K A; Payne F; Dina C; Froguel P; Mohlke K L; Willer C; Olsson T; Wareham N J; Hallmans G; Barroso I; Sandhu M S
Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.
Diabetologia 2008;51(3):458-63.
2008: Badii Ramin; Bener Abdulbari; Zirie Mahmoud; Al-Rikabi Ammar; Simsek Mehmet; Al-Hamaq Abdulla O A A; Ghoussaini Maya; Froguel Philippe; Wareham Nick J
Lack of association between the Pro12Ala polymorphism of the PPAR-gamma 2 gene and type 2 diabetes mellitus in the Qatari consanguineous population.
Acta diabetologica 2008;45(1):15-21.
2008: Flechtner Isabelle; Vaxillaire Martine; Cavé Hélène; Scharfmann Raphael; Froguel Philippe; Polak Michel
Neonatal hyperglycaemia and abnormal development of the pancreas.
Best practice & research. Clinical endocrinology & metabolism 2008;22(1):17-40.
2008: Cauchi Stéphane; Choquet Hélène; Gutiérrez-Aguilar Ruth; Capel Frédéric; Grau Katrine; Proença Christine; Dina Christian; Duval Alex; Balkau Beverley; Marre Michel; Potoczna Natascha; Langin Dominique; Horber Fritz; Sørensen Thorkild I A; Charpentier Guillaume; Meyre David; Froguel Philippe
Effects of TCF7L2 polymorphisms on obesity in European populations.
Obesity (Silver Spring, Md.) 2008;16(2):476-82.
2008: Le Stunff Catherine; Dechartres Agnès; Mariot Virginie; Lotton Chantal; Trainor Cecelia; Miraglia Del Giudice Emanuele; Meyre David; Bieche Ivan; Laurendeau Ingrid; Froguel Philippe; Zelenika Diana; Fallin Dani; Lathrop Mark; Roméo Paul-Henri; Bougnères Pierre
Association analysis indicates that a variant GATA-binding site in the PIK3CB promoter is a Cis-acting expression quantitative trait locus for this gene and attenuates insulin resistance in obese children.
Diabetes 2008;57(2):494-502.
2008: Duesing K; Charpentier G; Marre M; Tichet J; Hercberg S; Froguel P; Gibson F
Evaluating the association of common LMNA variants with type 2 diabetes and quantitative metabolic phenotypes in French Europids.
Diabetologia 2008;51(1):76-81.
2008: Vaxillaire Martine; Veslot Jacques; Dina Christian; Proença Christine; Cauchi Stéphane; Charpentier Guillaume; Tichet Jean; Fumeron Frédéric; Marre Michel; Meyre David; Balkau Beverley; Froguel Philippe;
Impact of common type 2 diabetes risk polymorphisms in the DESIR prospective study.
Diabetes 2008;57(1):244-54.
2008: Le Stunff Catherine; Dechartres Agnès; Miraglia Del Giudice Emanuele; Froguel Philippe; Bougnères Pierre
A single-nucleotide polymorphism in the p110beta gene promoter is associated with partial protection from insulin resistance in severely obese adolescents.
The Journal of clinical endocrinology and metabolism 2008;93(1):212-5.
2008: de Smith A J; Walters R G; Froguel P; Blakemore A I
Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease.
Cytogenetic and genome research 2008;123(1-4):17-26.
2008: de Smith Adam J; Walters Robin G; Coin Lachlan J M; Steinfeld Israel; Yakhini Zohar; Sladek Rob; Froguel Philippe; Blakemore Alexandra I F
Small deletion variants have stable breakpoints commonly associated with alu elements.
PloS one 2008;3(8):e3104.
2008: Cauchi Stéphane; Nead Kevin T; Choquet Hélène; Horber Fritz; Potoczna Natascha; Balkau Beverley; Marre Michel; Charpentier Guillaume; Froguel Philippe; Meyre David
The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
BMC medical genetics 2008;9():45.
2008: Cauchi Stéphane; Meyre David; Durand Emmanuelle; Proença Christine; Marre Michel; Hadjadj Samy; Choquet Hélène; De Graeve Franck; Gaget Stefan; Allegaert Frederic; Delplanque Jérôme; Permutt Marshall Alan; Wasson Jon; Blech Ilana; Charpentier Guillaume; Balkau Beverley; Vergnaud Anne-Claire; Czernichow Sébastien; Patsch Wolfgang; Chikri Mohamed; Glaser Benjamin; Sladek Robert; Froguel Philippe
Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
PloS one 2008;3(5):e2031.
2008: Duesing Konsta; Charpentier Guillaume; Marre Michel; Tichet Jean; Hercberg Serge; Balkau Beverley; Froguel Philippe; Gibson Fernando
Evaluating the association of common PBX1 variants with type 2 diabetes.
BMC medical genetics 2008;9():14.
2007: Couturier Cyril; Sarkis Chamsy; Séron Karin; Belouzard Sandrine; Chen Patty; Lenain Aude; Corset Laetitia; Dam Julie; Vauthier Virginie; Dubart Anne; Mallet Jacques; Froguel Philippe; Rouillé Yves; Jockers Ralf
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19476-81.
2007: Horikoshi M; Hara K; Ito C; Shojima N; Nagai R; Ueki K; Froguel P; Kadowaki T
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(12):2461-6.
2007: de Smith Adam J; Tsalenko Anya; Sampas Nick; Scheffer Alicia; Yamada N Alice; Tsang Peter; Ben-Dor Amir; Yakhini Zohar; Ellis Richard J; Bruhn Laurakay; Laderman Stephen; Froguel Philippe; Blakemore Alexandra I F
Array CGH analysis of copy number variation identifies 1284 new genes variant in healthy white males: implications for association studies of complex diseases.
Human molecular genetics 2007;16(23):2783-94.
2007: Porzio O; Massa O; Cunsolo V; Colombo C; Malaponti M; Bertuzzi F; Hansen T; Johansen A; Pedersen O; Meschi F; Terrinoni A; Melino G; Federici M; Decarlo N; Menicagli M; Campani D; Marchetti P; Ferdaoussi M; Froguel P; Federici G; Vaxillaire M; Barbetti F
Missense mutations in the TGM2 gene encoding transglutaminase 2 are found in patients with early-onset type 2 diabetes. Mutation in brief no. 982. Online.
Human mutation 2007;28(11):1150.
2007: Gutierrez-Aguilar R; Benmezroua Y; Balkau B; Marre M; Helbecque N; Charpentier G; Polychronakos C; Sladek R; Froguel P; Neve B
Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes.
Diabetes & metabolism 2007;33(5):372-8.
2007: Flechtner I; Vaxillaire M; Cavé H; Froguel P; Polak M
[Neonatal diabetes: a disease linked to multiple mechanisms]
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie 2007;14(11):1356-65.
2007: Ghoussaini Maya; Vatin Vincent; Lecoeur Cécile; Abkevich Victor; Younus Adib; Samson Chantal; Wachter Christophe; Heude Barbara; Tauber Maïté; Tounian Patrick; Hercberg Serge; Weill Jacques; Levy-Marchal Claire; Le Stunff Catherine; Bougnères Pierre; Froguel Philippe; Meyre David
Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity.
The Journal of clinical endocrinology and metabolism 2007;92(11):4403-9.
2007: Meyre D; Bouatia-Naji N; Vatin V; Veslot J; Samson C; Tichet J; Marre M; Balkau B; Froguel P
ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.
Diabetologia 2007;50(10):2090-6.
2007: Saunders Catherine L; Chiodini Benedetta D; Sham Pak; Lewis Cathryn M; Abkevich Victor; Adeyemo Adebowale A; de Andrade Mariza; Arya Rector; Berenson Gerald S; Blangero John; Boehnke Michael; Borecki Ingrid B; Chagnon Yvon C; Chen Wei; Comuzzie Anthony G; Deng Hong-Wen; Duggirala Ravindranath; Feitosa Mary F; Froguel Philippe; Hanson Robert L; Hebebrand Johannes; Huezo-Dias Patricia; Kissebah Ahmed H; Li Weidong; Luke Amy; Martin Lisa J; Nash Matthew; Ohman Miina; Palmer Lyle J; Peltonen Leena; Perola Markus; Price R Arlen; Redline Susan; Srinivasan Sathanur R; Stern Michael P; Stone Steven; Stringham Heather; Turner Stephen; Wijmenga Cisca; Collier David A
Meta-analysis of genome-wide linkage studies in BMI and obesity.
Obesity (Silver Spring, Md.) 2007;15(9):2263-75.
2007: Salonen Jukka T; Uimari Pekka; Aalto Juha-Matti; Pirskanen Mia; Kaikkonen Jari; Todorova Boryana; Hyppönen Jelena; Korhonen Veli-Pekka; Asikainen Janne; Devine Christopher; Tuomainen Tomi-Pekka; Luedemann Jan; Nauck Matthias; Kerner Wolfgang; Stephens Richard H; New John P; Ollier William E; Gibson J Martin; Payton Antony; Horan Michael A; Pendleton Neil; Mahoney Walt; Meyre David; Delplanque Jerôme; Froguel Philippe; Luzzatto Oren; Yakir Benjamin; Darvasi Ariel
Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
American journal of human genetics 2007;81(2):338-45.
2007: Stutzmann Fanny; Vatin Vincent; Cauchi Stéphane; Morandi Anita; Jouret Béatrice; Landt Olfert; Tounian Patrick; Levy-Marchal Claire; Buzzetti Raffaella; Pinelli Leonardo; Balkau Beverley; Horber Fritz; Bougnères Pierre; Froguel Philippe; Meyre David
Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene.
Human molecular genetics 2007;16(15):1837-44.
2007: Cauchi Stéphane; El Achhab Younes; Choquet Hélène; Dina Christian; Krempler Franz; Weitgasser Raimund; Nejjari Chakib; Patsch Wolfgang; Chikri Mohamed; Meyre David; Froguel Philippe
TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis.
Journal of molecular medicine (Berlin, Germany) 2007;85(7):777-82.
2007: Fanciulli Manuela; Norsworthy Penny J; Petretto Enrico; Dong Rong; Harper Lorraine; Kamesh Lavanya; Heward Joanne M; Gough Stephen C L; de Smith Adam; Blakemore Alexandra I F; Froguel Philippe; Owen Catherine J; Pearce Simon H S; Teixeira Luis; Guillevin Loic; Graham Deborah S Cunninghame; Pusey Charles D; Cook H Terence; Vyse Timothy J; Aitman Timothy J
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.
Nature genetics 2007;39(6):721-3.
2007: Dina Christian; Meyre David; Gallina Sophie; Durand Emmanuelle; Körner Antje; Jacobson Peter; Carlsson Lena M S; Kiess Wieland; Vatin Vincent; Lecoeur Cecile; Delplanque Jérome; Vaillant Emmanuel; Pattou François; Ruiz Juan; Weill Jacques; Levy-Marchal Claire; Horber Fritz; Potoczna Natascha; Hercberg Serge; Le Stunff Catherine; Bougnères Pierre; Kovacs Peter; Marre Michel; Balkau Beverley; Cauchi Stéphane; Chèvre Jean-Claude; Froguel Philippe
Variation in FTO contributes to childhood obesity and severe adult obesity.
Nature genetics 2007;39(6):724-6.
2007: Gueorguiev Maria; Wiltshire Steven; Garcia Edwin A; Mein Charles; Lecoeur Cecile; Kristen Brigitte; Allotey Rebecca; Hattersley Andrew T; Walker Mark; O'rahilly Stephen; Froguel Philippe; Grossman Ashley B; McCarthy Mark I; Hitman Graham A; Korbonits Márta
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2007;92(6):2201-4.
2007: Vaxillaire Martine; Dechaume Aurélie; Busiah Kanetee; Cavé Hélène; Pereira Sabrina; Scharfmann Raphael; de Nanclares Guiomar Perez; Castano Luis; Froguel Philippe; Polak Michel;
New ABCC8 mutations in relapsing neonatal diabetes and clinical features.
Diabetes 2007;56(6):1737-41.
2007: Valayannopoulos Vassili; Vaxillaire Martine; Aigrain Yves; Jaubert Francis; Bellanné-Chantelot Christine; Ribeiro Maria-Joao; Brunelle Francis; Froguel Philippe; Robert Jean-Jacques; Polak Michel; Nihoul-Fékété Claire; de Lonlay Pascale
Coexistence in the same family of both focal and diffuse forms of hyperinsulinism.
Diabetes care 2007;30(6):1590-2.
2007: Poulain-Godefroy Odile; Froguel Philippe
Preadipocyte response and impairment of differentiation in an inflammatory environment.
Biochemical and biophysical research communications 2007;356(3):662-7.
2007: Horikoshi M; Hara K; Ito C; Nagai R; Froguel P; Kadowaki T
A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
Diabetologia 2007;50(4):747-51.
2007: Fairbrother Una L; Tankó László B; Walley Andrew J; Christiansen Claus; Froguel Philippe; Blakemore Alexandra I F
Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(4):544-50.
2007: Owen Katharine R; Groves Christopher J; Hanson Robert L; Knowler William C; Shuldiner Alan R; Elbein Steven C; Mitchell Braxton D; Froguel Philippe; Ng Maggie C Y; Chan Juliana C; Jia Weiping; Deloukas Panos; Hitman Graham A; Walker Mark; Frayling Timothy M; Hattersley Andrew T; Zeggini Eleftheria; McCarthy Mark I
Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes: association analyses in 9,518 subjects.
Diabetes 2007;56(3):879-83.
2007: Chu Winston S; Das Swapan Kumar; Wang Hua; Chan Juliana C; Deloukas Panos; Froguel Philippe; Baier Leslie J; Jia Weiping; McCarthy Mark I; Ng Maggie C Y; Damcott Coleen; Shuldiner Alan R; Zeggini Eleftheria; Elbein Steven C
Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits.
Diabetes 2007;56(3):856-62.
2007: Yamauchi Toshimasa; Nio Yasunori; Maki Toshiyuki; Kobayashi Masaki; Takazawa Takeshi; Iwabu Masato; Okada-Iwabu Miki; Kawamoto Sachiko; Kubota Naoto; Kubota Tetsuya; Ito Yusuke; Kamon Junji; Tsuchida Atsushi; Kumagai Katsuyoshi; Kozono Hideki; Hada Yusuke; Ogata Hitomi; Tokuyama Kumpei; Tsunoda Masaki; Ide Tomohiro; Murakami Kouji; Awazawa Motoharu; Takamoto Iseki; Froguel Philippe; Hara Kazuo; Tobe Kazuyuki; Nagai Ryozo; Ueki Kohjiro; Kadowaki Takashi
Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.
Nature medicine 2007;13(3):332-9.
2007: Siddiq A; Gueorguiev M; Samson C; Hercberg S; Heude B; Levy-Marchal C; Jouret B; Weill J; Meyre D; Walley A; Froguel P
Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects.
Diabetologia 2007;50(3):574-84.
2007: Bell Christopher G; Meyre David; Petretto Enrico; Levy-Marchal Claire; Hercberg Serge; Charles Marie Aline; Boyle Cliona; Weill Jacques; Tauber Maïte; Mein Charles A; Aitman Timothy J; Froguel Philippe; Walley Andrew J
No contribution of angiotensin-converting enzyme (ACE) gene variants to severe obesity: a model for comprehensive case/control and quantitative cladistic analysis of ACE in human diseases.
European journal of human genetics : EJHG 2007;15(3):320-7.
2007: Sladek Robert; Rocheleau Ghislain; Rung Johan; Dina Christian; Shen Lishuang; Serre David; Boutin Philippe; Vincent Daniel; Belisle Alexandre; Hadjadj Samy; Balkau Beverley; Heude Barbara; Charpentier Guillaume; Hudson Thomas J; Montpetit Alexandre; Pshezhetsky Alexey V; Prentki Marc; Posner Barry I; Balding David J; Meyre David; Polychronakos Constantin; Froguel Philippe
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Nature 2007;445(7130):881-5.
2007: Vasseur Francis; Guérardel Audrey; Barat-Houari Mouna; Cottel Dominique; Amouyel Philippe; Froguel Philippe; Helbecque Nicole
Impact of a CART promoter genetic variation on plasma lipid profile in a general population.
Molecular genetics and metabolism 2007;90(2):199-204.
2007: Hummel M; Vasseur F; Mathieu C; Bellanne-Chantelot C; Froguel P; Standl E; Füchtenbusch M
Two Caucasian families with the hepatocyte nuclear factor-1alpha mutation Tyr218Cys.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(1):62-4.
2007: Dina Christian; Meyre David; Samson Chantal; Tichet Jean; Marre Michel; Jouret Beatrice; Charles Marie Aline; Balkau Beverley; Froguel Philippe
Comment on "A common genetic variant is associated with adult and childhood obesity".
Science (New York, N.Y.) 2007;315(5809):187; author reply 187.
2007: Cauchi S; Vaxillaire M; Choquet H; Durand E; Duval A; Polak M; Froguel P
No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects.
Diabetologia 2007;50(1):214-6.
2007: Flechtner Isabelle; Vaxillaire Martine; Cavé Hélène; Scharfmann Raphael; Froguel Philippe; Polak Michel
Diabetes in very young children and mutations in the insulin-secreting cell potassium channel genes: therapeutic consequences.
Endocrine development 2007;12():86-98.
2007: Gutiérrez-Aguilar Ruth; Benmezroua Yamina; Vaillant Emmanuel; Balkau Beverley; Marre Michel; Charpentier Guillaume; Sladek Rob; Froguel Philippe; Neve Bernadette
Analysis of KLF transcription factor family gene variants in type 2 diabetes.
BMC medical genetics 2007;8():53.
2007: Bouatia-Naji Nabila; Vatin Vincent; Lecoeur Cécile; Heude Barbara; Proença Christine; Veslot Jacques; Jouret Béatrice; Tichet Jean; Charpentier Guillaume; Marre Michel; Balkau Beverley; Froguel Philippe; Meyre David
Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity.
BMC medical genetics 2007;8():44.
2007: Cauchi Stéphane; Meyre David; Choquet Hélène; Deghmoun Samia; Durand Emmanuelle; Gaget Stefan; Lecoeur Cécile; Froguel Philippe; Levy-Marchal Claire
TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population.
BMC medical genetics 2007;8():37.
2006: Santos Jose L; Boutin Philippe; Verdich Camilla; Holst Claus; Larsen Lesli H; Toubro Soren; Dina Christian; Saris Wim H M; Blaak Ellen E; Hoffstedt Johnatan; Taylor Moira A; Polak Jan; Clement Karine; Langin Dominique; Astrup Arne; Froguel Philippe; Pedersen Oluf; Sorensen Thorkild I A; Martinez J Alfredo;
Genotype-by-nutrient interactions assessed in European obese women. A case-only study.
European journal of nutrition 2006;45(8):454-62.
2006: Cauchi Stéphane; Meyre David; Choquet Hélène; Dina Christian; Born Catherine; Marre Michel; Balkau Beverley; Froguel Philippe;
TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study.
Diabetes 2006;55(11):3189-92.
2006: Wiltshire S; Bell J T; Groves C J; Dina C; Hattersley A T; Frayling T M; Walker M; Hitman G A; Vaxillaire M; Farrall M; Froguel P; McCarthy M I
Epistasis between type 2 diabetes susceptibility Loci on chromosomes 1q21-25 and 10q23-26 in northern Europeans.
Annals of human genetics 2006;70(Pt 6):726-37.
2006: Cauchi Stéphane; Meyre David; Dina Christian; Choquet Hélène; Samson Chantal; Gallina Sophie; Balkau Beverley; Charpentier Guillaume; Pattou François; Stetsyuk Volodymyr; Scharfmann Raphaël; Staels Bart; Frühbeck Gema; Froguel Philippe
Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.
Diabetes 2006;55(10):2903-8.
2006: Benzinou Michael; Walley Andrew; Lobbens Stephan; Charles Marie-Aline; Jouret Béatrice; Fumeron Frédéric; Balkau Beverley; Meyre David; Froguel Philippe
Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians.
Diabetes 2006;55(10):2876-82.
2006: Walley Andrew J; Blakemore Alexandra I F; Froguel Philippe
Genetics of obesity and the prediction of risk for health.
Human molecular genetics 2006;15 Spec No 2():R124-30.
2006: Séron Karin; Corset Laetitia; Vasseur Francis; Boutin Philippe; Gómez-Ambrosi Javier; Salvador Javier; Frühbeck Gema; Froguel Philippe
Distinct impaired regulation of SOCS3 and long and short isoforms of the leptin receptor in visceral and subcutaneous fat of lean and obese women.
Biochemical and biophysical research communications 2006;348(4):1232-8.
2006: Das Swapan Kumar; Chu Winston S; Hale Terri C; Wang Xiaoqin; Craig Rebekah L; Wang Hua; Shuldiner Alan R; Froguel Philippe; Deloukas Panos; McCarthy Mark I; Zeggini Eleftheria; Hasstedt Sandra J; Elbein Steven C
Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.
Diabetes 2006;55(9):2631-9.
2006: Zeggini Eleftheria; Damcott Coleen M; Hanson Robert L; Karim Mohammad A; Rayner N William; Groves Christopher J; Baier Leslie J; Hale Terri C; Hattersley Andrew T; Hitman Graham A; Hunt Sarah E; Knowler William C; Mitchell Braxton D; Ng Maggie C Y; O'Connell Jeffrey R; Pollin Toni I; Vaxillaire Martine; Walker Mark; Wang Xiaoqin; Whittaker Pamela; Xiang Kunsan; Jia Weiping; Chan Juliana C N; Froguel Philippe; Deloukas Panos; Shuldiner Alan R; Elbein Steven C; McCarthy Mark I;
Variation within the gene encoding the upstream stimulatory factor 1 does not influence susceptibility to type 2 diabetes in samples from populations with replicated evidence of linkage to chromosome 1q.
Diabetes 2006;55(9):2541-8.
2006: Tsuchiya Takafumi; Schwarz Peter E H; Bosque-Plata Laura Del; Geoffrey Hayes M; Dina Christian; Froguel Philippe; Wayne Towers G; Fischer Sabine; Temelkova-Kurktschiev Theodora; Rietzsch Hannes; Graessler Juergen; Vcelák Josef; Palyzová Daniela; Selisko Thomas; Bendlová Bela; Schulze Jan; Julius Ulrich; Hanefeld Markolf; Weedon Michael N; Evans Julie C; Frayling Timothy M; Hattersley Andrew T; Orho-Melander Marju; Groop Leif; Malecki Maciej T; Hansen Torben; Pedersen Oluf; Fingerlin Tasha E; Boehnke Michael; Hanis Craig L; Cox Nancy J; Bell Graeme I
Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses.
Molecular genetics and metabolism 2006;89(1-2):174-84.
2006: Babenko Andrey P; Polak Michel; Cavé Hélène; Busiah Kanetee; Czernichow Paul; Scharfmann Raphael; Bryan Joseph; Aguilar-Bryan Lydia; Vaxillaire Martine; Froguel Philippe
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus.
The New England journal of medicine 2006;355(5):456-66.
2006: Sørensen Thorkild I A; Boutin Philippe; Taylor Moira A; Larsen Lesli H; Verdich Camilla; Petersen Liselotte; Holst Claus; Echwald Søren M; Dina Christian; Toubro Søren; Petersen Martin; Polak Jan; Clément Karine; Martínez J Alfredo; Langin Dominique; Oppert Jean-Michel; Stich Vladimir; Macdonald Ian; Arner Peter; Saris Wim H M; Pedersen Oluf; Astrup Arne; Froguel Philippe;
Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.
PLoS clinical trials 2006;1(2):e12.
2006: Vaxillaire Martine; Froguel Philippe
Genetic basis of maturity-onset diabetes of the young.
Endocrinology and metabolism clinics of North America 2006;35(2):371-84, x.
2006: Vu-Hong Thuy-Ai; Durand Emmanuelle; Deghmoun Samia; Boutin Philippe; Meyre David; Chevenne Didier; Czernichow Paul; Froguel Philippe; Levy-Marchal Claire
The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.
The Journal of clinical endocrinology and metabolism 2006;91(6):2437-40.
2006: Hara Kazuo; Horikoshi Momoko; Kitazato Hiroji; Ito Chikako; Noda Mitsuhiko; Ohashi Jun; Froguel Philippe; Tokunaga Katsushi; Tobe Kazuyuki; Nagai Ryozo; Kadowaki Takashi
Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.
Diabetes 2006;55(5):1260-4.
2006: Cheyssac Claire; Dina Christian; Leprêtre Frédéric; Vasseur-Delannoy Valérie; Dechaume Aurélie; Lobbens Stéphane; Balkau Beverley; Ruiz Juan; Charpentier Guillaume; Pattou François; Joly Erik; Prentki Marc; Hansen Torben; Pedersen Oluf; Vaxillaire Martine; Froguel Philippe
EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families.
Diabetes 2006;55(4):1171-6.
2006: Jaziri Riphed; Lobbens Stephane; Aubert Roberte; Péan Franck; Lahmidi Saida; Vaxillaire Martine; Porchay Isabelle; Bellili Naïma; Tichet Jean; Balkau Beverley; Froguel Philippe; Marre Michel; Fumeron Frédéric;
The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the Data From an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.
Diabetes 2006;55(4):1157-62.
2006: Meyre David; Froguel Philippe
[ENPP1, the first example of common genetic link between childhood and adult obesity and type 2 diabetes]
Médecine sciences : M/S 2006;22(3):308-12.
2006: Vaxillaire Martine; Dechaume Aurélie; Vasseur-Delannoy Valérie; Lahmidi Saida; Vatin Vincent; Leprêtre Frédéric; Boutin Philippe; Hercberg Serge; Charpentier Guillaume; Dina Christian; Froguel Philippe
Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population.
Diabetes 2006;55(3):856-61.
2006: Lee Yung Seng; Challis Ben G; Thompson Darren A; Yeo Giles S H; Keogh Julia M; Madonna Michael E; Wraight Vicki; Sims Matthew; Vatin Vincent; Meyre David; Shield Julian; Burren Christine; Ibrahim Zala; Cheetham Tim; Swift Peter; Blackwood Anthea; Hung Chiao-Chien Connie; Wareham Nicholas J; Froguel Philippe; Millhauser Glenn L; O'Rahilly Stephen; Farooqi I Sadaf
A POMC variant implicates beta-melanocyte-stimulating hormone in the control of human energy balance.
Cell metabolism 2006;3(2):135-40.
2006: Bouatia-Naji Nabila; Meyre David; Lobbens Stéphane; Séron Karin; Fumeron Frédéric; Balkau Beverley; Heude Barbara; Jouret Béatrice; Scherer Philipp E; Dina Christian; Weill Jacques; Froguel Philippe
ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity.
Diabetes 2006;55(2):545-50.
2006: Guérardel Audrey; Tankó László B; Boutin Philippe; Christiansen Claus; Froguel Philippe
Obesity susceptibility CART gene polymorphism contributes to bone remodeling in postmenopausal women.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2006;17(1):156-7.
2006: Vasseur Francis; Meyre David; Froguel Philippe
Adiponectin, type 2 diabetes and the metabolic syndrome: lessons from human genetic studies.
Expert reviews in molecular medicine 2006;8(27):1-12.
2006: Cheyssac Claire; Lecoeur Cécile; Dechaume Aurélie; Bibi Amina; Charpentier Guillaume; Balkau Beverley; Marre Michel; Froguel Philippe; Gibson Fernando; Vaxillaire Martine
Analysis of common PTPN1 gene variants in type 2 diabetes, obesity and associated phenotypes in the French population.
BMC medical genetics 2006;7():44.
2005: Lacquemant Corinne; Vasseur Francis; Leprêtre Frédéric; Froguel Philippe
[Adipocytokins, obesity and development of type 2 diabetes]
Médecine sciences : M/S 2005;21 Spec No():10-8.
2005: Tankó László B; Siddiq Afshan; Lecoeur Cécile; Larsen Philip J; Christiansen Claus; Walley Andrew; Froguel Philippe
ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity.
Obesity research 2005;13(12):2113-21.
2005: Grasberger Helmut; Vaxillaire Martine; Pannain Silvana; Beck John C; Mimouni-Bloch Aviva; Vatin Vincent; Vassart Gilbert; Froguel Philippe; Refetoff Samuel
Identification of a locus for nongoitrous congenital hypothyroidism on chromosome 15q25.3-26.1.
Human genetics 2005;118(3-4):348-55.
2005: Bell Christopher G; Meyre David; Samson Chantal; Boyle Cliona; Lecoeur Cécile; Tauber Maïte; Jouret Béatrice; Jaquet Delphine; Levy-Marchal Claire; Charles Marie Aline; Weill Jacques; Gibson Fernando; Mein Charles A; Froguel Philippe; Walley Andrew J
Association of melanin-concentrating hormone receptor 1 5' polymorphism with early-onset extreme obesity.
Diabetes 2005;54(10):3049-55.
2005: Gibson Fernando; Hercberg Serge; Froguel Philippe
Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians.
Diabetes 2005;54(10):3040-2.
2005: Siddiq Afshan; Lepretre Frederic; Hercberg Serge; Froguel Philippe; Gibson Fernando
A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians.
Diabetes 2005;54(8):2477-81.
2005: Meyre David; Bouatia-Naji Nabila; Tounian Agnès; Samson Chantal; Lecoeur Cécile; Vatin Vincent; Ghoussaini Maya; Wachter Christophe; Hercberg Serge; Charpentier Guillaume; Patsch Wolfgang; Pattou François; Charles Marie-Aline; Tounian Patrick; Clément Karine; Jouret Béatrice; Weill Jacques; Maddux Betty A; Goldfine Ira D; Walley Andrew; Boutin Philippe; Dina Christian; Froguel Philippe
Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
Nature genetics 2005;37(8):863-7.
2005: Boutin P; Froguel P
GAD2: a polygenic contribution to genetic susceptibility for common obesity?
Pathologie-biologie 2005;53(6):305-7.
2005: Hara K; Horikoshi M; Kitazato H; Yamauchi T; Ito C; Noda M; Ohashi J; Froguel P; Tokunaga K; Nagai R; Kadowaki T
Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.
Diabetologia 2005;48(7):1307-14.
2005: Vasseur F; Helbecque N; Lobbens S; Vasseur-Delannoy V; Dina C; Clément K; Boutin P; Kadowaki T; Scherer P E; Froguel P
Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity.
Diabetologia 2005;48(5):892-9.
2005: Meyre David; Boutin Philippe; Tounian Agnès; Deweirder Marianne; Aout Mounir; Jouret Béatrice; Heude Barbara; Weill Jacques; Tauber Maite; Tounian Patrick; Froguel Philippe
Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?
The Journal of clinical endocrinology and metabolism 2005;90(4):2384-90.
2005: Ghoussaini Maya; Meyre David; Lobbens Stéphane; Charpentier Guillaume; Clément Karine; Charles Marie-Aline; Tauber Maïté; Weill Jacques; Froguel Philippe
Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population.
BMC medical genetics 2005;6():11.
2005: Neve Bernadette; Fernandez-Zapico Martin E; Ashkenazi-Katalan Vered; Dina Christian; Hamid Yasmin H; Joly Erik; Vaillant Emmanuel; Benmezroua Yamina; Durand Emmanuelle; Bakaher Nicolas; Delannoy Valerie; Vaxillaire Martine; Cook Tiffany; Dallinga-Thie Geesje M; Jansen Hans; Charles Marie-Aline; Clément Karine; Galan Pilar; Hercberg Serge; Helbecque Nicole; Charpentier Guillaume; Prentki Marc; Hansen Torben; Pedersen Oluf; Urrutia Raul; Melloul Danielle; Froguel Philippe
Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(13):4807-12.
2005: Vaxillaire M; Dina C; Lobbens S; Dechaume A; Vasseur-Delannoy V; Helbecque N; Charpentier G; Froguel P
Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.
Diabetologia 2005;48(3):440-4.
2005: Bell Christopher G; Walley Andrew J; Froguel Philippe
The genetics of human obesity.
Nature reviews. Genetics 2005;6(3):221-34.
2005: Vozarova de Courten Barbora; Hanson Robert L; Funahashi Tohru; Lindsay Robert S; Matsuzawa Yuji; Tanaka Sachiyo; Thameem Farook; Gruber Jonathan D; Froguel Philippe; Wolford Johanna K
Common Polymorphisms in the Adiponectin Gene ACDC Are Not Associated With Diabetes in Pima Indians.
Diabetes 2005;54(1):284-9.
2005: Guérardel Audrey; Barat-Houari Mouna; Vasseur Francis; Dina Christian; Vatin Vincent; Clément Karine; Eberlé Delphine; Vasseur-Delannoy Valérie; Bell Christopher G; Galan Pilar; Hercberg Serge; Helbecque Nicole; Potoczna Natascha; Horber Fritz F; Boutin Philippe; Froguel Philippe
Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population.
BMC genetics 2005;6(1):19.
2004: Allotey R A; Mohan V; McDermott M F; Deepa R; Premalatha G; Hassan Z; Cassell P G; North B V; Vaxillaire M; Mein C A; Swan D C; O'Grady E; Ramachandran A; Snehalatha C; Sinnot P J; Hemmatpour S K; Froguel P; Hitman G A
The EIF2AK3 gene region and type I diabetes in subjects from South India.
Genes and immunity 2004;5(8):648-52.
2004: Leprêtre F; Linton K J; Lacquemant C; Vatin V; Samson C; Dina C; Chikri M; Ali S; Scherer P; Séron K; Vasseur F; Aitman T; Froguel P
Genetic study of the CD36 gene in a French diabetic population.
Diabetes & metabolism 2004;30(5):459-63.
2004: Gibson Fernando; Froguel Philippe
Genetics of the APM1 locus and its contribution to type 2 diabetes susceptibility in French Caucasians.
Diabetes 2004;53(11):2977-83.
2004: Vaxillaire Martine; Populaire Céline; Busiah Kanetee; Cavé Hélène; Gloyn Anna L; Hattersley Andrew T; Czernichow Paul; Froguel Philippe; Polak Michel
Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients.
Diabetes 2004;53(10):2719-22.
2004: Durand Emmanuelle; Boutin Philippe; Meyre David; Charles M Aline; Clement Karine; Dina Christian; Froguel Philippe
Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians.
Diabetes 2004;53(9):2483-6.
2004: Eberlé Delphine; Clément Karine; Meyre David; Sahbatou Mourad; Vaxillaire Martine; Le Gall Annie; Ferré Pascal; Basdevant Arnaud; Froguel Philippe; Foufelle Fabienne
SREBF-1 gene polymorphisms are associated with obesity and type 2 diabetes in French obese and diabetic cohorts.
Diabetes 2004;53(8):2153-7.
2004: Kipfer-Coudreau S; Eberlé D; Sahbatou M; Bonhomme A; Guy-Grand B; Froguel P; Galan P; Basdevant A; Clément K
Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects.
Diabetologia 2004;47(7):1278-84.
2004: Leprêtre Frédéric; Vasseur Francis; Vaxillaire Martine; Scherer Philipp E; Ali Saira; Linton Kenneth; Aitman Timothy; Froguel Philippe
A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes.
Human mutation 2004;24(1):104.
2004: Bell Christopher G; Benzinou Michael; Siddiq Afshan; Lecoeur Cécile; Dina Christian; Lemainque Arnaud; Clément Karine; Basdevant Arnaud; Guy-Grand Bernard; Mein Charles A; Meyre David; Froguel Philippe
Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q.
Diabetes 2004;53(7):1857-65.
2004: Lacquemant C; Froguel P; Lobbens S; Izzo P; Dina C; Ruiz J
The adiponectin gene SNP+45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(7):776-81.
2004: Tsuchida Atsushi; Yamauchi Toshimasa; Ito Yusuke; Hada Yusuke; Maki Toshiyuki; Takekawa Sato; Kamon Junji; Kobayashi Masaki; Suzuki Ryo; Hara Kazuo; Kubota Naoto; Terauchi Yasuo; Froguel Philippe; Nakae Jun; Kasuga Masato; Accili Domenico; Tobe Kazuyuki; Ueki Kohjiro; Nagai Ryozo; Kadowaki Takashi
Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity.
The Journal of biological chemistry 2004;279(29):30817-22.
2004: Weill J; Vanderbecken S; Froguel P
Understanding the rising incidence of type 2 diabetes in adolescence.
Archives of disease in childhood 2004;89(6):502-4.
2004: Leprêtre Frédéric; Cheyssac Claire; Amouyel Philippe; Froguel Philippe; Helbecque Nicole
A promoter polymorphism in CD36 is associated with an atherogenic lipid profile in a French general population.
Atherosclerosis 2004;173(2):375-7.
2004: Fumeron Frédéric; Aubert Roberte; Siddiq Afshan; Betoulle Dina; Péan Frank; Hadjadj Samy; Tichet Jean; Wilpart Elsie; Chesnier Marie-Claude; Balkau Beverley; Froguel Philippe; Marre Michel;
Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study.
Diabetes 2004;53(4):1150-7.
2004: Heude Barbara; Dubois Séverine; Charles Marie-Aline; Deweirder Marianne; Dina Christian; Borys Jean-Michel; Ducimetière Pierre; Froguel Philippe;
VNTR polymorphism of the insulin gene and childhood overweight in a general population.
Obesity research 2004;12(3):499-504.
2004: Meyre David; Lecoeur Cécile; Delplanque Jérôme; Francke Stephan; Vatin Vincent; Durand Emmanuelle; Weill Jacques; Dina Christian; Froguel Philippe
A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2.
Diabetes 2004;53(3):803-11.
2003: Boutin Philippe; Dina Christian; Vasseur Francis; Dubois Séverine; Corset Laetitia; Séron Karin; Bekris Lynn; Cabellon Janice; Neve Bernadette; Vasseur-Delannoy Valérie; Chikri Mohamed; Charles M Aline; Clement Karine; Lernmark Ake; Froguel Philippe
GAD2 on chromosome 10p12 is a candidate gene for human obesity.
PLoS biology 2003;1(3):E68.
2003: Yamauchi Toshimasa; Hara Kazuo; Kubota Naoto; Terauchi Yasuo; Tobe Kazuyuki; Froguel Philippe; Nagai Ryozo; Kadowaki Takashi
Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine.
Current drug targets. Immune, endocrine and metabolic disorders 2003;3(4):243-54.
2003: Coudreau Sylvie Kipfer; Tounian Patrick; Bonhomme Geneviève; Froguel Philippe; Girardet Jean-Philippe; Guy-Grand Bernard; Basdevant Arnaud; Clément Karine
Role of the DGAT gene C79T single-nucleotide polymorphism in French obese subjects.
Obesity research 2003;11(10):1163-7.
2003: Waki Hironori; Yamauchi Toshimasa; Kamon Junji; Ito Yusuke; Uchida Shoko; Kita Shunbun; Hara Kazuo; Hada Yusuke; Vasseur Francis; Froguel Philippe; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.
The Journal of biological chemistry 2003;278(41):40352-63.
2003: Lopes C; Dina C; Durand E; Froguel P
PAI-1 polymorphisms modulate phenotypes associated with the metabolic syndrome in obese and diabetic Caucasian population.
Diabetologia 2003;46(9):1284-90.
2003: Lacquemant Corinne; Vasseur Francis; Leprêtre Frédéric; Froguel Philippe
[Adipocytokins, obesity and development of type 2 diabetes]
Médecine sciences : M/S 2003;19(8-9):809-17.
2003: Demenais Florence; Kanninen Timo; Lindgren Cecilia M; Wiltshire Steven; Gaget Stéphane; Dandrieux Candice; Almgren Peter; Sjögren Marketa; Hattersley Andrew; Dina Christian; Tuomi Tiinamaija; McCarthy Mark I; Froguel Philippe; Groop Leif C
A meta-analysis of four European genome screens (GIFT Consortium) shows evidence for a novel region on chromosome 17p11.2-q22 linked to type 2 diabetes.
Human molecular genetics 2003;12(15):1865-73.
2003: Froguel Ph
[Maturity-onset diabetes of the young (MODY): the history of its dismemberment]
Annales d'endocrinologie 2003;64(3 Suppl):S12-6.
2003: Lubrano-Berthelier Cecile; Cavazos Martha; Dubern Beatrice; Shapiro Astrid; Stunff Catherine L E; Zhang Sumei; Picart Franck; Govaerts Cedric; Froguel Philippe; Bougneres Pierre; Clement Karine; Vaisse Christian
Molecular genetics of human obesity-associated MC4R mutations.
Annals of the New York Academy of Sciences 2003;994():49-57.
2003: Yamauchi Toshimasa; Kamon Junji; Ito Yusuke; Tsuchida Atsushi; Yokomizo Takehiko; Kita Shunbun; Sugiyama Takuya; Miyagishi Makoto; Hara Kazuo; Tsunoda Masaki; Murakami Koji; Ohteki Toshiaki; Uchida Shoko; Takekawa Sato; Waki Hironori; Tsuno Nelson H; Shibata Yoichi; Terauchi Yasuo; Froguel Philippe; Tobe Kazuyuki; Koyasu Shigeo; Taira Kazunari; Kitamura Toshio; Shimizu Takao; Nagai Ryozo; Kadowaki Takashi
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
Nature 2003;423(6941):762-9.
2003: Veiga-da-Cunha M; Delplanque J; Gillain A; Bonthron D T; Boutin P; Van Schaftingen E; Froguel P
Mutations in the glucokinase regulatory protein gene in 2p23 in obese French caucasians.
Diabetologia 2003;46(5):704-11.
2003: Beales Philip L; Badano Jose L; Ross Alison J; Ansley Stephen J; Hoskins Bethan E; Kirsten Brigitta; Mein Charles A; Froguel Philippe; Scambler Peter J; Lewis Richard Alan; Lupski James R; Katsanis Nicholas
Genetic interaction of BBS1 mutations with alleles at other BBS loci can result in non-Mendelian Bardet-Biedl syndrome.
American journal of human genetics 2003;72(5):1187-99.
2003: Helbecque N; Abderrahamani A; Meylan L; Riederer B; Mooser V; Miklossy J; Delplanque J; Boutin P; Nicod P; Haefliger J-A; Cottel D; Amouyel P; Froguel P; Waeber G;
Islet-brain1/C-Jun N-terminal kinase interacting protein-1 (IB1/JIP-1) promoter variant is associated with Alzheimer's disease.
Molecular psychiatry 2003;8(4):413-22, 363.
2003: Vasseur Francis; Leprêtre Frédéric; Lacquemant Corinne; Froguel Philippe
The genetics of adiponectin.
Current diabetes reports 2003;3(2):151-8.
2003: Populaire C; Mori Y; Dina C; Vasseur F; Vaxillaire M; Kadowaki T; Froguel P
Does the -11377 promoter variant of APM1 gene contribute to the genetic risk for Type 2 diabetes mellitus in Japanese families?
Diabetologia 2003;46(3):443-5.
2003: Frayling Timothy M; Lindgren Cecilia M; Chevre Jean Claude; Menzel Stephan; Wishart Marie; Benmezroua Yamina; Brown Alison; Evans Julie C; Rao Pamidghantam Subba; Dina Christian; Lecoeur Cécile; Kanninen Timo; Almgren Peter; Bulman Michael P; Wang Youxiang; Mills James; Wright-Pascoe Rosemarie; Mahtani Melanie M; Prisco Francesco; Costa Angels; Cognet Ignacio; Hansen Torben; Pedersen Oluf; Ellard Sian; Tuomi Tiinamaija; Groop Leif C; Froguel Philippe; Hattersley Andrew T; Vaxillaire Martine
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Diabetes 2003;52(3):872-81.
2003: Lubrano-Berthelier Cecile; Durand Emmanuelle; Dubern Beatrice; Shapiro Astrid; Dazin Paul; Weill Jacques; Ferron Camille; Froguel Philippe; Vaisse Christian
Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations.
Human molecular genetics 2003;12(2):145-53.
2003: Yamauchi Toshimasa; Kamon Junji; Waki Hironori; Imai Yasushi; Shimozawa Nobuhiro; Hioki Kyouji; Uchida Shoko; Ito Yusuke; Takakuwa Keisuke; Matsui Junji; Takata Makoto; Eto Kazuhiro; Terauchi Yasuo; Komeda Kajuro; Tsunoda Masaki; Murakami Koji; Ohnishi Yasuyuki; Naitoh Takeshi; Yamamura Kenichi; Ueyama Yoshito; Froguel Philippe; Kimura Satoshi; Nagai Ryozo; Kadowaki Takashi
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
The Journal of biological chemistry 2003;278(4):2461-8.
2003: Leprêtre F; Delannoy V; Froguel P; Vasseur F; Montpellier C
Dissection of an inverted X(p21.3q27.1) chromosome associated with mental retardation.
Cytogenetic and genome research 2003;101(2):124-9.
2002: Martin Lisa J; Comuzzie Anthony G; Dupont Sophie; Vionnet Nathalie; Dina Christian; Gallina Sophie; Houari Mouna; Blangero John; Froguel Philippe
A quantitative trait locus influencing type 2 diabetes susceptibility maps to a region on 5q in an extended French family.
Diabetes 2002;51(12):3568-72.
2002: Yamauchi T; Kamon J; Minokoshi Y; Ito Y; Waki H; Uchida S; Yamashita S; Noda M; Kita S; Ueki K; Eto K; Akanuma Y; Froguel P; Foufelle F; Ferre P; Carling D; Kimura S; Nagai R; Kahn B B; Kadowaki T
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase.
Nature medicine 2002;8(11):1288-95.
2002: Vasseur Francis; Helbecque Nicole; Dina Christian; Lobbens Stéphane; Delannoy Valérie; Gaget Stéphane; Boutin Philippe; Vaxillaire Martine; Leprêtre Frédéric; Dupont Sophie; Hara Kazuo; Clément Karine; Bihain Bernard; Kadowaki Takashi; Froguel Philippe
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.
Human molecular genetics 2002;11(21):2607-14.
2002: Mitchell S M S; Vaxillaire M; Thomas H; Parrizas M; Benmezroua Y; Costa A; Hansen T; Owen K R; Tuomi T; Pirie F; Ryffel G U; Ferrer J; Froguel P; Hattersley A T; Frayling T M
Rare variants identified in the HNF- 4 alpha beta-cell-specific promoter and alternative exon 1 lack biological significance in maturity onset diabetes of the young and young onset Type II diabetes.
Diabetologia 2002;45(9):1344-8.
2002: Challis Benjamin G; Pritchard Lynn E; Creemers John W M; Delplanque Jerome; Keogh Julia M; Luan Jian'an; Wareham Nicholas J; Yeo Giles S H; Bhattacharyya Sumit; Froguel Phillipe; White Anne; Farooqi I Sadaf; O'Rahilly Stephen
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Human molecular genetics 2002;11(17):1997-2004.
2002: Korbonits Márta; Gueorguiev Maria; O'Grady Eithne; Lecoeur Cecile; Swan Daniel C; Mein Charles A; Weill Jacques; Grossman Ashley B; Froguel Philippe
A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children.
The Journal of clinical endocrinology and metabolism 2002;87(8):4005-8.
2002: McCarthy Mark I; Froguel Philippe
Genetic approaches to the molecular understanding of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E217-25.
2002: Kubota Naoto; Terauchi Yasuo; Yamauchi Toshimasa; Kubota Tetsuya; Moroi Masao; Matsui Junji; Eto Kazuhiro; Yamashita Tokuyuki; Kamon Junji; Satoh Hidemi; Yano Wataru; Froguel Philippe; Nagai Ryozo; Kimura Satoshi; Kadowaki Takashi; Noda Tetsuo
Disruption of adiponectin causes insulin resistance and neointimal formation.
The Journal of biological chemistry 2002;277(29):25863-6.
2002: Reis A F; Hani E H; Beressi N; Robert J J; Bresson J L; Froguel P; Velho G
Allelic variation in exon 18 of the sulfonylurea receptor 1 (SUR1) gene, insulin secretion and insulin sensitivity in nondiabetic relatives of type 2 diabetic subjects.
Diabetes & metabolism 2002;28(3):209-15.
2002: Neve B; Froguel P; Corset L; Vaillant E; Vatin V; Boutin P
Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing.
BioTechniques 2002;32(5):1138-42.
2002: Barat-Houari Mouna; Clément Karine; Vatin Vincent; Dina Christian; Bonhomme Geneviève; Vasseur Francis; Guy-Grand Bernard; Froguel Philippe
Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.
Diabetes 2002;51(5):1640-3.
2002: Lacquemant C; Chikri M; Boutin P; Samson C; Froguel P
No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.
Diabetologia 2002;45(4):602-3; author reply 604.
2002: Mori Yasumichi; Otabe Shuichi; Dina Christian; Yasuda Kazuki; Populaire Céline; Lecoeur Cécile; Vatin Vincent; Durand Emmanuelle; Hara Kazuo; Okada Terumasa; Tobe Kazuyuki; Boutin Philippe; Kadowaki Takashi; Froguel Philippe
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.
Diabetes 2002;51(4):1247-55.
2002: Vaxillaire M; Samson C; Cavé H; Metz C; Froguel P; Polak M
Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France.
Diabetologia 2002;45(3):454-5.
2002: Stride A; Vaxillaire M; Tuomi T; Barbetti F; Njølstad P R; Hansen T; Costa A; Conget I; Pedersen O; Søvik O; Lorini R; Groop L; Froguel P; Hattersley A T
The genetic abnormality in the beta cell determines the response to an oral glucose load.
Diabetologia 2002;45(3):427-35.
2002: Collet C; Ducorps M; Mayaudon H; Dupuy O; Ceppa F; Boutin P; Froguel P; Bauduceau B
Prevalence of the missense mutation Gly574Ser in the hepatocyte nuclear factor-1alpha in Africans with diabetes.
Diabetes & metabolism 2002;28(1):39-44.
2002: Delplanque J; Vasseur F; Durand E; Abderrahmani A; Dina C; Waeber G; Guy-Grand B; Clement K; Weill J; Boutin P; Froguel P
Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians.
The Journal of clinical endocrinology and metabolism 2002;87(2):867-9.
2002: Hara Kazuo; Boutin Philippe; Mori Yasumichi; Tobe Kazuyuki; Dina Christian; Yasuda Kazuki; Yamauchi Toshimasa; Otabe Shuichi; Okada Terumasa; Eto Kazuhiro; Kadowaki Hiroko; Hagura Ryoko; Akanuma Yasuo; Yazaki Yoshio; Nagai Ryozo; Taniyama Matsuo; Matsubara Koichi; Yoda Madoka; Nakano Yasuko; Tomita Motowo; Kimura Satoshi; Ito Chikako; Froguel Philippe; Kadowaki Takashi
Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.
Diabetes 2002;51(2):536-40.
2002: Marchal-Victorion Sophie; Vionnet Nathalie; Escrieut Chantal; Dematos Frédérique; Dina Christian; Dufresne Marlène; Vaysse Nicole; Pradayrol Lucien; Froguel Philippe; Fourmy Daniel
Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients.
Pharmacogenetics 2002;12(1):23-30.
2002: Clement Karine; Boutin Philippe; Froguel Philippe
Genetics of obesity.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2002;2(3):177-87.
2001: Froguel P; Boutin P
Genetics of pathways regulating body weight in the development of obesity in humans.
Experimental biology and medicine (Maywood, N.J.) 2001;226(11):991-6.
2001: Francke S; Manraj M; Lacquemant C; Lecoeur C; Leprêtre F; Passa P; Hebe A; Corset L; Yan S L; Lahmidi S; Jankee S; Gunness T K; Ramjuttun U S; Balgobin V; Dina C; Froguel P
A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27.
Human molecular genetics 2001;10(24):2751-65.
2001: Boutin P; Froguel P
Genetics of human obesity.
Best practice & research. Clinical endocrinology & metabolism 2001;15(3):391-404.
2001: Dubern B; Clément K; Pelloux V; Froguel P; Girardet J P; Guy-Grand B; Tounian P
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children.
The Journal of pediatrics 2001;139(2):204-9.
2001: Yamauchi T; Kamon J; Waki H; Terauchi Y; Kubota N; Hara K; Mori Y; Ide T; Murakami K; Tsuboyama-Kasaoka N; Ezaki O; Akanuma Y; Gavrilova O; Vinson C; Reitman M L; Kagechika H; Shudo K; Yoda M; Nakano Y; Tobe K; Nagai R; Kimura S; Tomita M; Froguel P; Kadowaki T
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Nature medicine 2001;7(8):941-6.
2001: Moore T; Hecquet S; McLellann A; Ville D; Grid D; Picard F; Moulard B; Asherson P; Makoff A J; McCormick D; Nashef L; Froguel P; Arzimanoglou A; LeGuern E; Bailleul B
Polymorphism analysis of JRK/JH8, the human homologue of mouse jerky, and description of a rare mutation in a case of CAE evolving to JME.
Epilepsy research 2001;46(2):157-67.
2001: Martin C C; Bischof L J; Bergman B; Hornbuckle L A; Hilliker C; Frigeri C; Wahl D; Svitek C A; Wong R; Goldman J K; Oeser J K; Leprêtre F; Froguel P; O'Brien R M; Hutton J C
Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes.
The Journal of biological chemistry 2001;276(27):25197-207.
2001: Vaxillaire M; Benmezroua Y; Durand E; Vasseur F; Froguel P
No evidence for diabetes-associated mutations of PEK/EIF2AK3 gene in French patients with early-onset type II diabetes.
Diabetologia 2001;44(6):786.
2001: Boutin P; Vasseur F; Samson C; Wahl C; Froguel P
Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?
Diabetologia 2001;44(6):775-8.
2001: Hani E H; Dupont S; Durand E; Dina C; Gallina S; Gantz I; Froguel P
Naturally occurring mutations in the melanocortin receptor 3 gene are not associated with type 2 diabetes mellitus in French Caucasians.
The Journal of clinical endocrinology and metabolism 2001;86(6):2895-8.
2001: Dupont S; Hani E H; Cras-Méneur C; De Matos F; Lobbens S; Lecoeur C; Vaxillaire M; Scharfmann R; Froguel P
No evidence for linkage or for diabetes-associated mutations in the activin type 2B receptor gene (ACVR2B) in French patients with mature-onset diabetes of the young or type 2 diabetes.
Diabetes 2001;50(5):1219-21.
2001: Pearson E R; Velho G; Clark P; Stride A; Shepherd M; Frayling T M; Bulman M P; Ellard S; Froguel P; Hattersley A T
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
Diabetes 2001;50 Suppl 1():S101-7.
2001: Manraj M; Francke S; Hébé A; Ramjuttun U S; Froguel P
Genetic and environmental nature of the insulin resistance syndrome in Indo-Mauritian subjects with premature coronary heart disease: contribution of beta3-adrenoreceptor gene polymorphism and beta blockers on triglyceride and HDL concentrations.
Diabetologia 2001;44(1):115-22.
2001: Leprêtre F; Montpellier C; Delannoy V; Froguel P; Vasseur F
Molecular and cytogenetic characterisation of a small interstitial de novo 20p13-->p12.3 deletion in a patient with severe growth deficit.
Cytogenetics and cell genetics 2001;94(3-4):142-6.
2001: Froguel P; Velho G
Genetic determinants of type 2 diabetes.
Recent progress in hormone research 2001;56():91-105.
2000: Froguel P
[Genetics of type II diabetes]
Archives des maladies du coeur et des vaisseaux 2000;93 Spec No 4():7-12.
2000: Delplanque J; Barat-Houari M; Dina C; Gallina P; Clément K; Guy-Grand B; Vasseur F; Boutin P; Froguel P
Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families.
Diabetologia 2000;43(12):1554-7.
2000: Froguel P
[Genomic approach to obesity: understanding a complex syndrome]
Annales d'endocrinologie 2000;61 Suppl 6():50-55.
2000: Froguel P
[Recent advances in the genetics of obesity]
Annales d'endocrinologie 2000;61 Suppl 6():3.
2000: Vionnet N; Hani El H; Dupont S; Gallina S; Francke S; Dotte S; De Matos F; Durand E; Leprêtre F; Lecoeur C; Gallina P; Zekiri L; Dina C; Froguel P
Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24.
American journal of human genetics 2000;67(6):1470-80.
2000: Meirhaeghe A; Amouyel P; Helbecque N; Cottel D; Otabe S; Froguel P; Vasseur F
An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort.
Diabetologia 2000;43(11):1424-8.
2000: Lacquemant C; Lepretre F; Pineda Torra I; Manraj M; Charpentier G; Ruiz J; Staels B; Froguel P
Mutation screening of the PPARalpha gene in type 2 diabetes associated with coronary heart disease.
Diabetes & metabolism 2000;26(5):393-401.
2000: Pontoglio M; Prié D; Cheret C; Doyen A; Leroy C; Froguel P; Velho G; Yaniv M; Friedlander G
HNF1alpha controls renal glucose reabsorption in mouse and man.
EMBO reports 2000;1(4):359-65.
2000: Velho G; Hattersley A T; Froguel P
Maternal diabetes alters birth weight in glucokinase-deficient (MODY2) kindred but has no influence on adult weight, height, insulin secretion or insulin sensitivity.
Diabetologia 2000;43(8):1060-3.
2000: James R W; Leviev I; Ruiz J; Passa P; Froguel P; Garin M C
Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients.
Diabetes 2000;49(8):1390-3.
2000: Lahlou N; Clement K; Carel J C; Vaisse C; Lotton C; Le Bihan Y; Basdevant A; Lebouc Y; Froguel P; Roger M; Guy-Grand B
Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass.
Diabetes 2000;49(8):1347-52.
2000: Vaisse C; Clement K; Durand E; Hercberg S; Guy-Grand B; Froguel P
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.
The Journal of clinical investigation 2000;106(2):253-62.
2000: Mercer J G; Moar K M; Hoggard N; Strosberg A D; Froguel P; Bailleul B
B219/OB-R 5'-UTR and leptin receptor gene-related protein gene expression in mouse brain and placenta: tissue-specific leptin receptor promoter activity.
Journal of neuroendocrinology 2000;12(7):649-55.
2000: Lacquemant C; Gaucher C; Delorme C; Chatellier G; Gallois Y; Rodier M; Passa P; Balkau B; Mazurier C; Marre M; Froguel P
Association between high von willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes. The GENEDIAB Study Group and the DESIR Study Group.
Kidney international 2000;57(4):1437-43.
2000: Costa A; Bescós M; Velho G; Chêvre J; Vidal J; Sesmilo G; Bellanné-Chantelot C; Froguel P; Casamitjana R; Rivera-Fillat F; Gomis R; Conget I
Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families.
European journal of endocrinology / European Federation of Endocrine Societies 2000;142(4):380-6.
2000: Froguel P; Guy-Grand B; Clément K
Genetics of obesity: towards the understanding of a complex syndrome]
Presse médicale (Paris, France : 1983) 2000;29(10):564-71.
2000: Clement K; Hercberg S; Passinge B; Galan P; Varroud-Vial M; Shuldiner A R; Beamer B A; Charpentier G; Guy-Grand B; Froguel P; Vaisse C
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000;24(3):391-3.
2000: Waeber G; Delplanque J; Bonny C; Mooser V; Steinmann M; Widmann C; Maillard A; Miklossy J; Dina C; Hani E H; Vionnet N; Nicod P; Boutin P; Froguel P
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
Nature genetics 2000;24(3):291-5.
2000: Abderrahmani A; Chèvre J C; Otabe S; Chikri M; Hani E H; Vaxillaire M; Hinokio Y; Horikawa Y; Bell G I; Froguel P
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
Diabetes 2000;49(2):306-8.
2000: Otabe S; Clement K; Dina C; Pelloux V; Guy-Grand B; Froguel P; Vasseur F
A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity.
Diabetologia 2000;43(2):245-9.
2000: Boutin P; Wahl C; Samson C; Vasseur F; Laget F; Froguel P
Big Dye terminator cycle sequencing chemistry: accuracy of the dilution process and application for screening mutations in the TCF1 and GCK genes.
Human mutation 2000;15(2):201-3.
2000: Godart F; Bellanné-Chantelot C; Clauin S; Gragnoli C; Abderrahmani A; Blanché H; Boutin P; Chèvre J C; Froguel P; Bailleul B
Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.
Human mutation 2000;15(2):173-80.
1999: Dupont S; Dina C; Hani E H; Froguel P
Absence of replication in the French population of the association between beta 2/NEUROD-A45T polymorphism and type 1 diabetes.
Diabetes & metabolism 1999;25(6):516-7.
1999: Vaxillaire M; Pueyo M E; Clément K; Fiet J; Timsit J; Philippe J; Robert J J; Tappy L; Froguel P; Velho G
Insulin secretion and insulin sensitivity in diabetic and non-diabetic subjects with hepatic nuclear factor-1alpha (maturity-onset diabetes of the young-3) mutations.
European journal of endocrinology / European Federation of Endocrine Societies 1999;141(6):609-18.
1999: Vaxillaire M; Abderrahmani A; Boutin P; Bailleul B; Froguel P; Yaniv M; Pontoglio M
Anatomy of a homeoprotein revealed by the analysis of human MODY3 mutations.
The Journal of biological chemistry 1999;274(50):35639-46.
1999: Hani E H; Stoffers D A; Chèvre J C; Durand E; Stanojevic V; Dina C; Habener J F; Froguel P
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.
The Journal of clinical investigation 1999;104(9):R41-8.
1999: Froguel P
The role of transcription factors in the pathogenesis of type 2 diabetes.
International journal of clinical practice. Supplement 1999;107():2-5.
1999: der Merwe M T; Panz V R; Crowther N J; Schlaphoff G P; Gray I P; Froguel P; Joffe B I; Lönnroth P N
Free fatty acids and insulin levels--relationship to leptin levels and body composition in various patient groups from South Africa.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1999;23(9):909-17.
1999: Massin P; Virally-Monod M; Vialettes B; Paques M; Gin H; Porokhov B; Caillat-Zucman S; Froguel P; Paquis-Fluckinger V; Gaudric A; Guillausseau P J
Prevalence of macular pattern dystrophy in maternally inherited diabetes and deafness. GEDIAM Group.
Ophthalmology 1999;106(9):1821-7.
1999: Boullu-Sanchis S; Leprêtre F; Hedelin G; Donnet J P; Schaffer P; Froguel P; Pinget M
Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism.
Diabetes & metabolism 1999;25(2):150-6.
1999: Dupont S; Vionnet N; Chèvre J C; Gallina S; Dina C; Seino Y; Yamada Y; Froguel P
No evidence of linkage or diabetes-associated mutations in the transcription factors BETA2/NEUROD1 and PAX4 in Type II diabetes in France.
Diabetologia 1999;42(4):480-4.
1999: Boutin P; Gresh L; Cisse A; Hara M; Bell G; Babu S; Eisenbarth G; Froguel P
Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children.
Diabetologia 1999;42(3):380-1.
1999: Clément K; Dina C; Basdevant A; Chastang N; Pelloux V; Lahlou N; Berlan M; Langin D; Guy-Grand B; Froguel P
A sib-pair analysis study of 15 candidate genes in French families with morbid obesity: indication for linkage with islet 1 locus on chromosome 5q.
Diabetes 1999;48(2):398-402.
1999: Otabe S; Clement K; Dubois S; Lepretre F; Pelloux V; Leibel R; Chung W; Boutin P; Guy-Grand B; Froguel P; Vasseur F
Mutation screening and association studies of the human uncoupling protein 3 gene in normoglycemic and diabetic morbidly obese patients.
Diabetes 1999;48(1):206-8.
1999: Froguel P
[What have we learned thanks to genetics in type II diabetes and its complications?]
Néphrologie 1999;20(2):59-63.
1998: Froguel P
Nuclear factors and type 2 diabetes.
Schweizerische medizinische Wochenschrift 1998;128(49):1936-9.
1998: Hani E H; Boutin P; Durand E; Inoue H; Permutt M A; Velho G; Froguel P
Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians.
Diabetologia 1998;41(12):1511-5.
1998: Froguel P
The genetics of complex traits: from diabetes mellitus to obesity.
Pathologie-biologie 1998;46(9):713-4.
1998: Hager J; Dina C; Francke S; Dubois S; Houari M; Vatin V; Vaillant E; Lorentz N; Basdevant A; Clement K; Guy-Grand B; Froguel P
A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10.
Nature genetics 1998;20(3):304-8.
1998: Vaisse C; Clement K; Guy-Grand B; Froguel P
A frameshift mutation in human MC4R is associated with a dominant form of obesity.
Nature genetics 1998;20(2):113-4.
1998: Dupont S; Dubois D; Vionnet N; Boitard C; Caillat-Zucman S; Timsit J; Froguel P
No association between the Friedreich's ataxia gene and NIDDM in the French population.
Diabetes 1998;47(10):1654-6.
1998: Chèvre J C; Hani E H; Boutin P; Vaxillaire M; Blanché H; Vionnet N; Pardini V C; Timsit J; Larger E; Charpentier G; Beckers D; Maes M; Bellanné-Chantelot C; Velho G; Froguel P
Mutation screening in 18 Caucasian families suggest the existence of other MODY genes.
Diabetologia 1998;41(9):1017-23.
1998: Surmely J F; Guenat E; Philippe J; Dussoix P; Schneiter P; Temler E; Vaxillaire M; Froguel P; Jéquier E; Tappy L
Glucose utilization and production in patients with maturity-onset diabetes of the young caused by a mutation of the hepatocyte nuclear factor-1alpha gene.
Diabetes 1998;47(9):1459-63.
1998: Leprêtre F; Vionnet N; Budhan S; Dina C; Powell K L; Génin E; Das A K; Nallam V; Passa P; Froguel P
Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery.
Diabetes & metabolism 1998;24(3):244-50.
1998: Pontoglio M; Sreenan S; Roe M; Pugh W; Ostrega D; Doyen A; Pick A J; Baldwin A; Velho G; Froguel P; Levisetti M; Bonner-Weir S; Bell G I; Yaniv M; Polonsky K S
Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice.
The Journal of clinical investigation 1998;101(10):2215-22.
1998: Chèvre J C; Hani E H; Stoffers D A; Habener J F; Froguel P
Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians.
Diabetes 1998;47(5):843-4.
1998: Otabe S; Clement K; Rich N; Warden C; Pecqueur C; Neverova M; Raimbault S; Guy-Grand B; Basdevant A; Ricquier D; Froguel P; Vasseur F
Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients: lack of association between new UCP 2 polymorphisms and obesity in French Caucasians.
Diabetes 1998;47(5):840-2.
1998: Rolland V; Clément K; Dugail I; Guy-Grand B; Basdevant A; Froguel P; Lavau M
Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity.
Obesity research 1998;6(2):122-7.
1998: Velho G; Froguel P
Genetic, metabolic and clinical characteristics of maturity onset diabetes of the young.
European journal of endocrinology / European Federation of Endocrine Societies 1998;138(3):233-9.
1998: Hager J; Clement K; Francke S; Dina C; Raison J; Lahlou N; Rich N; Pelloux V; Basdevant A; Guy-Grand B; North M; Froguel P
A polymorphism in the 5' untranslated region of the human ob gene is associated with low leptin levels.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1998;22(3):200-5.
1998: Clément K; Vaisse C; Lahlou N; Cabrol S; Pelloux V; Cassuto D; Gourmelen M; Dina C; Chambaz J; Lacorte J M; Basdevant A; Bougnères P; Lebouc Y; Froguel P; Guy-Grand B
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.
Nature 1998;392(6674):398-401.
1998: Hani E H; Suaud L; Boutin P; Chèvre J C; Durand E; Philippi A; Demenais F; Vionnet N; Furuta H; Velho G; Bell G I; Laine B; Froguel P
A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1998;101(3):521-6.
1998: Vionnet N; Froguel P
[Genetic risk of non-insulin-dependent diabetes]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1998;():223-40.
1997: Boutin P; Chèvre J C; Hani E H; Gomis R; Pardini V C; Guillausseau P J; Vaxillaire M; Velho G; Froguel P
An automated fluorescent single-strand conformation polymorphism technique for screening mutations in the hepatocyte nuclear factor-1alpha gene (maturity-onset diabetes of the young).
Diabetes 1997;46(12):2108-9.
1997: Clement K; Manning B S; Basdevant A; Strosberg A D; Guy-Grand B; Froguel P
Gender effect of the Trp64Arg mutation in the beta 3 adrenergic receptor gene on weight gain in morbid obesity.
Diabetes & metabolism 1997;23(5):424-7.
1997: Julier C; Delépine M; Keavney B; Terwilliger J; Davis S; Weeks D E; Bui T; Jeunemaître X; Velho G; Froguel P; Ratcliffe P; Corvol P; Soubrier F; Lathrop G M
Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.
Human molecular genetics 1997;6(12):2077-85.
1997: Francke S; Clement K; Dina C; Inoue H; Behn P; Vatin V; Basdevant A; Guy-Grand B; Permutt M A; Froguel P; Hager J
Genetic studies of the leptin receptor gene in morbidly obese French Caucasian families.
Human genetics 1997;100(5-6):491-6.
1997: Boutin P; Hani E H; Vasseur F; Roche C; Bailleul B; Hager J; Froguel P
Automated fluorescence-based screening for mutation by SSCP: use of universal M13 dye primers for labeling and detection.
BioTechniques 1997;23(3):358-62.
1997: Zouali H; Hani E H; Philippi A; Vionnet N; Beckmann J S; Demenais F; Froguel P
A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene.
Human molecular genetics 1997;6(9):1401-8.
1997: Clément K; Lahlou N; Ruiz J; Hager J; Bougnères P; Basdevant A; Guy-Grand B; Froguel P
Association of poorly controlled diabetes with low serum leptin in morbid obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1997;21(7):556-61.
1997: Hani E H; Hager J; Philippi A; Demenais F; Froguel P; Vionnet N
Mapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q.
Diabetes 1997;46(7):1225-6.
1997: Roche C; Boutin P; Dina C; Gyapay G; Basdevant A; Hager J; Guy-Grand B; Clément K; Froguel P
Genetic studies of neuropeptide Y and neuropeptide Y receptors Y1 and Y5 regions in morbid obesity.
Diabetologia 1997;40(6):671-5.
1997: Lesage S; Velho G; Vionnet N; Chatelain N; Demenais F; Passa P; Soubrier F; Froguel P
Genetic studies of the renin-angiotensin system in arterial hypertension associated with non-insulin-dependent diabetes mellitus.
Journal of hypertension 1997;15(6):601-6.
1997: Vionnet N; Hani E H; Lesage S; Philippi A; Hager J; Varret M; Stoffel M; Tanizawa Y; Chiu K C; Glaser B; Permutt M A; Passa P; Demenais F; Froguel P
Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs.
Diabetes 1997;46(6):1062-8.
1997: Lesage S; Zouali H; Vionnet N; Philippi A; Velho G; Serradas P; Passa P; Demenais F; Froguel P
Genetic analyses of glucose transporter genes in French non-insulin-dependent diabetic families.
Diabetes & metabolism 1997;23(2):137-42.
1997: Vaxillaire M; Rouard M; Yamagata K; Oda N; Kaisaki P J; Boriraj V V; Chevre J C; Boccio V; Cox R D; Lathrop G M; Dussoix P; Philippe J; Timsit J; Charpentier G; Velho G; Bell G I; Froguel P
Identification of nine novel mutations in the hepatocyte nuclear factor 1 alpha gene associated with maturity-onset diabetes of the young (MODY3).
Human molecular genetics 1997;6(4):583-6.
1997: Hani E H; Clément K; Velho G; Vionnet N; Hager J; Philippi A; Dina C; Inoue H; Permutt M A; Basdevant A; North M; Demenais F; Guy-Grand B; Froguel P
Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians.
Diabetes 1997;46(4):688-94.
1997: Dussoix P; Vaxillaire M; Iynedjian P B; Tiercy J M; Ruiz J; Spinas G A; Berger W; Zahnd G; Froguel P; Philippe J
Diagnostic heterogeneity of diabetes in lean young adults: classification based on immunological and genetic parameters.
Diabetes 1997;46(4):622-31.
1997: Velho G; Froguel P
Maturity-onset diabetes of the young (MODY), MODY genes and non-insulin-dependent diabetes mellitus.
Diabetes & metabolism 1997;23 Suppl 2():34-7.
1997: Ktorza A; Bernard C; Parent V; Penicaud L; Froguel P; Lathrop M; Gauguier D
Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?
Diabetes & metabolism 1997;23 Suppl 2():38-46.
1997: Froguel P
Tracking down genes to cure diabetes: an achievable task for the 21st century?
Diabetes & metabolism 1997;23 Suppl 2():8-13.
1997: Velho G; Froguel P
Genetic determinants of non-insulin-dependent diabetes mellitus: strategies and recent results.
Diabetes & metabolism 1997;23(1):7-17.
1997: Velho G; Blanché H; Vaxillaire M; Bellanné-Chantelot C; Pardini V C; Timsit J; Passa P; Deschamps I; Robert J J; Weber I T; Marotta D; Pilkis S J; Lipkind G M; Bell G I; Froguel P
Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
Diabetologia 1997;40(2):217-24.
1997: Garin M C; James R W; Dussoix P; Blanché H; Passa P; Froguel P; Ruiz J
Paraoxonase polymorphism Met-Leu54 is associated with modified serum concentrations of the enzyme. A possible link between the paraoxonase gene and increased risk of cardiovascular disease in diabetes.
The Journal of clinical investigation 1997;99(1):62-6.
1997: Delépine M; Pociot F; Habita C; Hashimoto L; Froguel P; Rotter J; Cambon-Thomsen A; Deschamps I; Djoulah S; Weissenbach J; Nerup J; Lathrop M; Julier C
Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6.
American journal of human genetics 1997;60(1):174-87.
1997: Froguel P
Genetics of type 1 insulin-dependent diabetes mellitus.
Hormone research 1997;48 Suppl 4():55-7.
1996: Hani E H; Zouali H; Philippi A; Beaudoin J C; Vionnet N; Passa P; Demenais F; Froguel P
Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus.
Diabetes & metabolism 1996;22(6):451-4.
1996: Clément K; Ruiz J; Cassard-Doulcier A M; Bouillaud F; Ricquier D; Basdevant A; Guy-Grand B; Froguel P
Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(12):1062-6.
1996: Byrne M M; Sturis J; Menzel S; Yamagata K; Fajans S S; Dronsfield M J; Bain S C; Hattersley A T; Velho G; Froguel P; Bell G I; Polonsky K S
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12.
Diabetes 1996;45(11):1503-10.
1996: Velho G; Petersen K F; Perseghin G; Hwang J H; Rothman D L; Pueyo M E; Cline G W; Froguel P; Shulman G I
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
The Journal of clinical investigation 1996;98(8):1755-61.
1996: Froguel P
Glucokinase and MODY: from the gene to the disease.
Diabetic medicine : a journal of the British Diabetic Association 1996;13(9 Suppl 6):S96-7.
1996: Velho G; Vaxillaire M; Boccio V; Charpentier G; Froguel P
Diabetes complications in NIDDM kindreds linked to the MODY3 locus on chromosome 12q.
Diabetes care 1996;19(9):915-9.
1996: Clément K; Philippi A; Jury C; Pividal R; Hager J; Demenais F; Basdevant A; Guy-Grand B; Froguel P
Candidate gene approach of familial morbid obesity: linkage analysis of the glucocorticoid receptor gene.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1996;20(6):507-12.
1996: Clement K; Garner C; Hager J; Philippi A; LeDuc C; Carey A; Harris T J; Jury C; Cardon L R; Basdevant A; Demenais F; Guy-Grand B; North M; Froguel P
Indication for linkage of the human OB gene region with extreme obesity.
Diabetes 1996;45(5):687-90.
1996: Velho G; Byrne M M; Clément K; Sturis J; Pueyo M E; Blanché H; Vionnet N; Fiet J; Passa P; Robert J J; Polonsky K S; Froguel P
Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation.
Diabetes 1996;45(4):478-87.
1996: Aoki M; Koranyi L; Riggs A C; Wasson J; Chiu K C; Vaxillaire M; Froguel P; Gough S; Liu L; Donis-Keller H
Identification of trinucleotide repeat-containing genes in human pancreatic islets.
Diabetes 1996;45(2):157-64.
1996: Clément K; Pueyo M E; Vaxillaire M; Rakotoambinina B; Thuillier F; Passa P; Froguel P; Robert J J; Velho G
Assessment of insulin sensitivity in glucokinase-deficient subjects.
Diabetologia 1996;39(1):82-90.
1996: Gauguier D; Froguel P; Parent V; Bernard C; Bihoreau M T; Portha B; James M R; Penicaud L; Lathrop M; Ktorza A
Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat.
Nature genetics 1996;12(1):38-43.
1995: Lesage S; Hani E H; Philippi A; Vaxillaire M; Hager J; Passa P; Demenais F; Froguel P; Vionnet N
Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM.
Diabetes 1995;44(10):1243-7.
1995: Gremlich S; Porret A; Hani E H; Cherif D; Vionnet N; Froguel P; Thorens B
Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor.
Diabetes 1995;44(10):1202-8.
1995: Ruiz J; Blanché H; James R W; Garin M C; Vaisse C; Charpentier G; Cohen N; Morabia A; Passa P; Froguel P
Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes.
Lancet 1995;346(8979):869-72.
1995: Clément K; Vaisse C; Manning B S; Basdevant A; Guy-Grand B; Ruiz J; Silver K D; Shuldiner A R; Froguel P; Strosberg A D
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.
The New England journal of medicine 1995;333(6):352-4.
1995: Riggs A C; Tanizawa Y; Aoki M; Wasson J; Ferrer J; Rabin D U; Vaxillaire M; Froguel P; Permutt M A
Characterization of the LIM/homeodomain gene islet-1 and single nucleotide screening in NIDDM.
Diabetes 1995;44(6):689-94.
1995: Malaisse W J; Pueyo M E; Nadi A B; Malaisse-Lagae F; Froguel P; Velho G
D-glucose metabolism in lymphocytes of patients with mitochondrial point mutation of the tRNALeu(UUR) gene.
Biochemical and molecular medicine 1995;54(2):91-5.
1995: Vaxillaire M; Boccio V; Philippi A; Vigouroux C; Terwilliger J; Passa P; Beckmann J S; Velho G; Lathrop G M; Froguel P
A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q.
Nature genetics 1995;9(4):418-23.
1995: Froguel P; Vionnet N
Genetics of non-insulin-dependent diabetes mellitus: from genes to the disease.
Advances in nephrology from the Necker Hospital 1995;24():157-63.
1994: Pueyo M E; Clement K; Vaxillaire M; Passa P; Froguel P; Robert J J; Velho G
Arginine-induced insulin release in glucokinase-deficient subjects.
Diabetes care 1994;17(9):1015-21.
1994: Tanizawa Y; Riggs A C; Dagogo-Jack S; Vaxillaire M; Froguel P; Liu L; Donis-Keller H; Permutt M A
Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]
Diabetes 1994;43(7):935-41.
1994: Ruiz J; Thillet J; Huby T; James R W; Erlich D; Flandre P; Froguel P; Chapman J; Passa P
Association of elevated lipoprotein(a) levels and coronary heart disease in NIDDM patients. Relationship with apolipoprotein(a) phenotypes.
Diabetologia 1994;37(6):585-91.
1994: Sturis J; Kurland I J; Byrne M M; Mosekilde E; Froguel P; Pilkis S J; Bell G I; Polonsky K S
Compensation in pancreatic beta-cell function in subjects with glucokinase mutations.
Diabetes 1994;43(5):718-23.
1994: Blanché H; Hager J; Sun F; Dausset J; Cohen D; Froguel P; Cohen N
Nonradioactive screening of glucokinase mutations in maturity onset diabetes of the young.
BioTechniques 1994;16(5):866-8, 870, 873-6.
1994: Ruiz J; Blanché H; Cohen N; Velho G; Cambien F; Cohen D; Passa P; Froguel P
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3662-5.
1994: Gauguier D; Nelson I; Bernard C; Parent V; Marsac C; Cohen D; Froguel P
Higher maternal than paternal inheritance of diabetes in GK rats.
Diabetes 1994;43(2):220-4.
1994: Schächter F; Faure-Delanef L; Guénot F; Rouger H; Froguel P; Lesueur-Ginot L; Cohen D
Genetic associations with human longevity at the APOE and ACE loci.
Nature genetics 1994;6(1):29-32.
1993: Hager J; Zouali H; Velho G; Froguel P
Insulin receptor substrate (IRS-1) gene polymorphisms in French NIDDM families.
Lancet 1993;342(8884):1430.
1993: Takeda J; Gidh-Jain M; Xu L Z; Froguel P; Velho G; Vaxillaire M; Cohen D; Shimada F; Makino H; Nishi S
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
The Journal of biological chemistry 1993;268(20):15200-4.
1993: Velho G; Erlich D; Turpin E; Néel D; Cohen D; Froguel P; Passa P
Lipoprotein(a) in diabetic patients and normoglycemic relatives in familial NIDDM.
Diabetes care 1993;16(5):742-7.
1993: Zouali H; Velho G; Froguel P
Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus.
The New England journal of medicine 1993;328(21):1568; author reply 1569.
1993: Gidh-Jain M; Takeda J; Xu L Z; Lange A J; Vionnet N; Stoffel M; Froguel P; Velho G; Sun F; Cohen D
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(5):1932-6.
1993: Froguel P; Zouali H; Vionnet N; Velho G; Vaxillaire M; Sun F; Lesage S; Stoffel M; Takeda J; Passa P
Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
The New England journal of medicine 1993;328(10):697-702.
1993: Froguel P; Velho G
[Glucokinase and non-insulin-dependent diabetes: from gene to disease]
Journées annuelles de diabétologie de l'Hôtel-Dieu 1993;():51-61.
1992: Stoffel M; Froguel P; Takeda J; Zouali H; Vionnet N; Nishi S; Weber I T; Harrison R W; Pilkis S J; Lesage S
Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7698-702.
1992: Velho G; Froguel P; Clement K; Pueyo M E; Rakotoambinina B; Zouali H; Passa P; Cohen D; Robert J J
Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.
Lancet 1992;340(8817):444-8.
1992: Froguel P; Vaxillaire M; Sun F; Velho G; Zouali H; Butel M O; Lesage S; Vionnet N; Clément K; Fougerousse F
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.
Nature 1992;356(6365):162-4.
1991: Julier C; Hyer R N; Davies J; Merlin F; Soularue P; Briant L; Cathelineau G; Deschamps I; Rotter J I; Froguel P
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility.
Nature 1991;354(6349):155-9.
1991: Froguel P; Vionnet N; Lesage S; Velho G; Cohen D
Two TaqI RFLPs at the GLUT2 locus in French Caucasian population.
Nucleic acids research 1991;19(20):5799.
1991: Froguel P; Zouali H; Sun F; Velho G; Fukumoto H; Passa P; Cohen D
CA repeat polymorphism in the glucose transporter GLUT 2 gene.
Nucleic acids research 1991;19(13):3754.

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