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Laurent Kremer

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Rosa Milagros Corrales; Jade Leiba; Virginie Molle; Martin Cohen-Gonsaud; Laurent Kremer
Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.
Dhinakaran Sambandan; Catherine Vilchèze; Brian Charles Weinrick; Laurent Kremer; Anil Ojha; Gurdyal S Besra; Dee N Dao; Sudagar S Gurcha; Graham F Hatfull; William R Jacobs
Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis.
Laila Gannoun-Zaki; Laurent Kremer; Laeticia Alibaud; Séverine Carrère-Kremer; Anne-Béatrice Blanc-Potard
Overexpression of the KdpF Membrane Peptide in Mycobacterium bovis BCG Results in Reduced Intramacrophage Growth and Altered Cording Morphology.

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All Publications

2013: Rosa Milagros Corrales; Jade Leiba; Virginie Molle; Martin Cohen-Gonsaud; Laurent Kremer
Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.
Biochemical and biophysical research communications 2013;430(2):858-64.
2013: Dhinakaran Sambandan; Catherine Vilchèze; Brian Charles Weinrick; Laurent Kremer; Anil Ojha; Gurdyal S Besra; Dee N Dao; Sudagar S Gurcha; Graham F Hatfull; William R Jacobs
Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis.
mBio 2013;4(3):.
2013: Laila Gannoun-Zaki; Laurent Kremer; Laeticia Alibaud; Séverine Carrère-Kremer; Anne-Béatrice Blanc-Potard
Overexpression of the KdpF Membrane Peptide in Mycobacterium bovis BCG Results in Reduced Intramacrophage Growth and Altered Cording Morphology.
PloS one 2013;8(4):e60379.
2013: Geoffrey D Coxon; Derek Craig; Laila Gannoun-Zaki; Rosa Milagros Corrales; Emilie Vialla; Laurent Kremer
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues.
PloS one 2013;8(1):e53162.
2013: Laila Gannoun-Zaki; Laeticia Alibaud; Laurent Kremer
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy 2013;57(1):629-32.
2012: Yinshan Yang; Séverine Carrère-Kremer; Martin Cohen-Gonsaud; Kevin Esteves; Laurent Kremer; Gilles Labesse; Anne-Béatrice Blanc-Potard
The C-terminal domain of the virulence factor MgtC is a divergent ACT domain.
Journal of bacteriology 2012;194(22):6255-63.
2012: Virginie Driss; Yann Guerardel; Emmanuel Hermann; Laurent Kremer; Fanny Legrand; Sylvie Loiseau; Marie Delbeke; David Dombrowicz; Monique Capron
CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan.
Immunology letters 2012;143(2):202-7.
2011: Romain Veyron-Churlet; Belinda Brust; Laurent Kremer; Anne-Béatrice Blanc-Potard
Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG.
Tuberculosis (Edinburgh, Scotland) 2011;91(6):544-8.
2011: Yoann Rombouts; Caroline Tokarski; Laurent Kremer; Emmanuel Maes; Laeticia Alibaud; Séverine Carrère-Kremer; Elisabeth Elass; Yann Guérardel
Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR_2343) protein.
The Journal of biological chemistry 2011;286(38):33678-88.
2011: Laeticia Alibaud; Adeline Burguière; Jeffrey D Cirillo; Suat L G Cirillo; Jean-François Dubremetz; Yann Guérardel; Georges Lutfalla; Yoann Rombouts; Xavier Trivelli; Laurent Kremer
A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos.
Molecular microbiology 2011;80(4):919-34.
2011: Belinda Brust; Stéphane Canaan; Luc Dedieu; Mélanie Lecoufle; Edouard Tuaillon; Viviane Valverde; Laurent Kremer
Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis.
PloS one 2011;6(9):e25078.
2010: Virginie Molle; Gulcin Gulten; Catherine Vilchèze; Romain Veyron-Churlet; Isabelle Zanella-Cléon; James C Sacchettini; William R. Jacobs Jr.; Laurent Kremer
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.
Molecular microbiology 2010;78(6):1591-605.
2010: Yoann Rombouts; Elisabeth Elass; Christophe Biot; Emmanuel Maes; Bernadette Coddeville; Adeline Burguière; Caroline Tokarski; Eric Buisine; Xavier Trivelli; Laurent Kremer; Yann Guérardel
Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum.
Journal of the American Chemical Society 2010;132(45):16073-84.
2010: Virginie Molle; Jade Leiba; Isabelle Zanella-Cléon; Michel Becchi; Laurent Kremer
An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates.
Proteomics 2010;10(21):3910-5.
2010: Laeticia Alibaud; Anuradha Alahari; Xavier Trivelli; Anil K Ojha; Graham F Hatfull; Yann Guerardel; Laurent Kremer
Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-mycolates.
The Journal of biological chemistry 2010;285(28):21698-707.
2010: Anil K Ojha; Xavier Trivelli; Yann Guerardel; Laurent Kremer; Graham F Hatfull
Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms.
The Journal of biological chemistry 2010;285(23):17380-9.
2010: Romain Veyron-Churlet; Isabelle Zanella-Cléon; Martin Cohen-Gonsaud; Virginie Molle; Laurent Kremer
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis.
The Journal of biological chemistry 2010;285(17):12714-25.
2010: Virginie Molle; Laurent Kremer
Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way.
Molecular microbiology 2010;75(5):1064-77.
2009: Yoann Rombouts; Adeline Burguière; Emmanuel Maes; Bernadette Coddeville; Elisabeth Elass; Yann Guérardel; Laurent Kremer
Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages.
The Journal of biological chemistry 2009;284(31):20975-88.
2009: Martin Cohen-Gonsaud; Philippe Barthe; Marc J Canova; Charlotte Stagier-Simon; Laurent Kremer; Christian Roumestand; Virginie Molle
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation.
The Journal of biological chemistry 2009;284(29):19290-300.
2009: Philippe Barthe; Christian Roumestand; Marc J Canova; Laurent Kremer; Corinne Hurard; Virginie Molle; Martin Cohen-Gonsaud
Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism.
Structure (London, England : 1993) 2009;17(4):568-78.
2009: Virginie Driss; Fanny Legrand; Emmanuel Hermann; Sylvie Loiseau; Yann Guerardel; Laurent Kremer; Estelle Adam; Gaëtane Woerly; David Dombrowicz; Monique Capron
TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins.
Blood 2009;113(14):3235-44.
2009: Marc J Canova; Laurent Kremer; Virginie Molle
The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases.
Journal of bacteriology 2009;191(8):2876-83.
2009: Romain Veyron-Churlet; Virginie Molle; Rebecca C Taylor; Alistair K Brown; Gurdyal S Besra; Isabelle Zanella-Cléon; Klaus Fütterer; Laurent Kremer
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue.
The Journal of biological chemistry 2009;284(10):6414-24.
2009: Anuradha Alahari; Laeticia Alibaud; Xavier Trivelli; Radhika Gupta; Gyanu Lamichhane; Robert C Reynolds; William R Bishai; Yann Guerardel; Laurent Kremer
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis.
Molecular microbiology 2009;71(5):1263-77.
2009: Paul Gratraud; Enlli Huws; Brie Falkard; Sophie Adjalley; Fidock David; Laurence Berry; William R. Jacobs Jr.; Mark S Baird; Henri VIAL; Laurent Kremer
Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target.
PloS one 2009;4(9):e6889.
2008: Min Yu; T R Santha Kumar; Louis J Nkrumah; Alida Coppi; Silke Retzlaff; Celeste D Li; Brendan J Kelly; Pedro A Moura; Viswanathan Lakshmanan; Joel S Freundlich; Juan-Carlos Valderramos; Catherine Vilcheze; Mark Siedner; Jennifer H-C Tsai; Brie Falkard; Amar Bir Singh Sidhu; Lisa A Purcell; Paul Gratraud; Laurent Kremer; Andrew P Waters; Guy Schiehser; David P Jacobus; Chris J Janse; Arba Ager; William R. Jacobs Jr.; James C Sacchettini; Volker Heussler; Photini Sinnis; Fidock David
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell host & microbe 2008;4(6):567-78.
2008: Marc J Canova; Laurent Kremer; Virginie Molle
pETPhos: a customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates.
Plasmid 2008;60(2):149-53.
2008: Anil K Ojha; Anthony D Baughn; Dhinakaran Sambandan; Tsungda Hsu; Xavier Trivelli; Yann Guerardel; Anuradha Alahari; Laurent Kremer; William R. Jacobs Jr.; Graham F Hatfull
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Molecular microbiology 2008;69(1):164-74.
2008: Maria Fiuza; Marc J Canova; Isabelle Zanella-Cléon; Michel Becchi; Alain J Cozzone; Luis Mateos; Laurent Kremer; José A. Gil; Virginie Molle
From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division.
The Journal of biological chemistry 2008;283(26):18099-112.
2008: Luke Alderwick; Lynn Dover; Natacha Veerapen; Sudagar S Gurcha; Laurent Kremer; David L Roper; Ashish K Pathak; Robert C Reynolds; Gurdyal S Besra
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosis.
Protein expression and purification 2008;58(2):332-41.
2008: Paul Gratraud; Namita Surolia; Gurdyal S Besra; Avadhesha Surolia; Laurent Kremer
Antimycobacterial Activity and Mechanism of Action of NAS-91.
Antimicrobial agents and chemotherapy 2008;52(3):1162-6.
2008: Virginie Molle; Robert C Reynolds; Luke Alderwick; Gurdyal S Besra; Alain J Cozzone; Klaus Fütterer; Laurent Kremer
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR.
The Biochemical journal 2008;410(2):309-17.
2008: Elisabeth Elass; Bernadette Coddeville; Laurent Kremer; Marlène Mortuaire; Joel Mazurier; Yann Guérardel
Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages.
FEBS letters 2008;582(3):445-50.
2008: Marc J Canova; Romain Veyron-Churlet; Isabelle Zanella-Cleon; Martin Cohen-Gonsaud; Alain J Cozzone; Michel Becchi; Laurent Kremer; Virginie Molle
The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c.
Proteomics 2008;8(3):521-33.
2008: Kanhu C Mishra; Chantal de Chastellier; Yeddula Narayana; Pablo Bifani; Alistair K Brown; Gurdyal S Besra; Vishwa M Katoch; Beenu Joshi; Kithiganahalli N Balaji; Laurent Kremer
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY.
Infection and immunity 2008;76(1):127-40.
2007: Emmanuel Maes; Bernadette Coddeville; Laurent Kremer; Yann Guérardel
Polysaccharide structural variability in mycobacteria: identification and characterization of phosphorylated mannan and arabinomannan.
Glycoconjugate journal 2007;24(8):439-48.
2007: Hemza Ghadbane; Alistair K Brown; Laurent Kremer; Gurdyal S Besra; Klaus Fütterer
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT).
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 10):831-5.
2007: Anuradha Alahari; Nathalie Saint; Sylvie Campagna; Virginie Molle; Gérard Molle; Laurent Kremer
The N-terminal domain of OmpATb is required for membrane translocation and pore-forming activity in mycobacteria.
Journal of bacteriology 2007;189(17):6351-8.
2007: Apoorva Bhatt; Virginie Molle; Gurdyal S Besra; William R. Jacobs Jr.; Laurent Kremer
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development.
Molecular microbiology 2007;64(6):1442-54.
2007: Elisabeth Elass; Bernadette Coddeville; Yann Guérardel; Laurent Kremer; Emmanuel Maes; Joel Mazurier; Dominique Legrand
Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein.
FEBS letters 2007;581(7):1383-90.
2007: Apoorva Bhatt; Nagatoshi Fujiwara; Kiranmai Bhatt; Sudagar S Gurcha; Laurent Kremer; Bing Chen; John Chan; Steven A Porcelli; Kazuo Kobayashi; Gurdyal S Besra; William R. Jacobs Jr.
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5157-62.
2007: Marie-Pierre Puissegur; Guillaume Lay; Martine GILLERON; Laure Botella; Jerome Nigou; Hedia Marrakchi; Bernard Mari; Jean-Luc Duteyrat; Yann Guerardel; Laurent Kremer; Pascal Barbry; Germain Puzo; Frédéric Altare
Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(5):3161-9.
2007: Lynn Dover; Anuradha Alahari; Paul Gratraud; Jessica M Gomes; Veemal Bhowruth; Robert C Reynolds; Gurdyal S Besra; Laurent Kremer
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.
Antimicrobial agents and chemotherapy 2007;51(3):1055-63.
2007: sudharsan sridharan; Lei Wang; Alistair K Brown; Lynn Dover; Laurent Kremer; Gurdyal S Besra; James C Sacchettini
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB).
Journal of molecular biology 2007;366(2):469-80.
2007: Anuradha Alahari; Xavier Trivelli; Yann Guérardel; Lynn Dover; Gurdyal S Besra; James C Sacchettini; Robert C Reynolds; Geoffrey D Coxon; Laurent Kremer
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria.
PloS one 2007;2(12):e1343.
2006: Virginie Molle; Alistair K Brown; Gurdyal S Besra; Alain J Cozzone; Laurent Kremer
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
The Journal of biological chemistry 2006;281(40):30094-103.
2006: Catherine Vilchèze; Feng Wang; Masayoshi Arai; Manzour Hernando Hazbón; Roberto Colangeli; Laurent Kremer; Torin R Weisbrod; David Alland; James C Sacchettini; William R. Jacobs Jr.
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid.
Nature medicine 2006;12(9):1027-9.
2006: Virginie Molle; Nathalie Saint; Sylvie Campagna; Laurent Kremer; Edward J A Lea; Philip Draper; Gérard Molle
pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection.
Molecular microbiology 2006;61(3):826-37.
2006: HECTOR MORBIDONI; Catherine Vilchèze; Laurent Kremer; Robert Bittman; James C Sacchettini; William R. Jacobs Jr.
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids.
Chemistry & biology 2006;13(3):297-307.
2006: Luke Alderwick; Virginie Molle; Laurent Kremer; Alain J Cozzone; Timothy R Dafforn; Gurdyal S Besra; Klaus Fütterer
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2558-63.
2005: Adeline Burguière; Paul G Hitchen; Lynn Dover; Laurent Kremer; Malin Ridell; David C Alexander; Jun Liu; Howard R Morris; David E Minnikin; Anne Dell; Gurdyal S Besra
LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.
The Journal of biological chemistry 2005;280(51):42124-33.
2005: Anil Ojha; Mridula Anand; Apoorva Bhatt; Laurent Kremer; William R. Jacobs Jr.; Graham F Hatfull
GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria.
Cell 2005;123(5):861-73.
2005: Apoorva Bhatt; Laurent Kremer; Annie Z Dai; James C Sacchettini; William R. Jacobs Jr.
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.
Journal of bacteriology 2005;187(22):7596-606.
2005: Elisabeth Elass; Laëtitia Aubry; Maryse Masson; Agnès Denys; Yann Guérardel; Emmanuel Maes; Dominique Legrand; Joel Mazurier; Laurent Kremer
Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism.
Infection and immunity 2005;73(10):7064-8.
2005: Alistair K Brown; sudharsan sridharan; Laurent Kremer; Sandra Lindenberg; Lynn Dover; James C Sacchettini; Gurdyal S Besra
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
The Journal of biological chemistry 2005;280(37):32539-47.
2005: Laurent Kremer; Chantal de Chastellier; Gary Dobson; Kevin J C Gibson; Pablo Bifani; Stéphanie Balor; Jean-Pierre Gorvel; Camille Locht; David E Minnikin; Gurdyal S Besra
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.
Molecular microbiology 2005;57(4):1113-26.
2005: Franck Biet; Catherine Duez; Laurent Kremer; Philippe Marquillies; L Amniai; André-Bernard Tonnel; Camille Locht; Joël PESTEL
Recombinant Mycobacterium bovis BCG producing IL-18 reduces IL-5 production and bronchoalveolar eosinophilia induced by an allergic reaction.
Allergy 2005;60(8):1065-72.
2005: Catherine Vilchèze; Torin R Weisbrod; Bing Chen; Laurent Kremer; Manzour Hernando Hazbón; Feng Wang; David Alland; James C Sacchettini; William R. Jacobs Jr.
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.
Antimicrobial agents and chemotherapy 2005;49(2):708-20.
2004: Volker Briken; Steven A Porcelli; Gurdyal S Besra; Laurent Kremer
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
Molecular microbiology 2004;53(2):391-403.
2004: D N Dao; Laurent Kremer; Yann Guérardel; A Molano; William R. Jacobs Jr.; Steven A Porcelli; Volker Briken
Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages.
Infection and immunity 2004;72(4):2067-74.
2004: Valerie QUESNIAUX; Delphine M Nicolle; David Torres; Laurent Kremer; Yann Guérardel; Jerome Nigou; Germain Puzo; François Erard; Bernhard RYFFEL
Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4425-34.
2004: Rosalind A Wilson; William N Maughan; Laurent Kremer; Gurdyal S Besra; Klaus Fütterer
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases.
Journal of molecular biology 2004;335(2):519-30.
2004: Simon J Waddell; Richard A Stabler; Kenneth Laing; Laurent Kremer; Robert C Reynolds; Gurdyal S Besra
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds.
Tuberculosis (Edinburgh, Scotland) 2004;84(3-4):263-74.
2003: Virginie Molle; Laurent Kremer; Christine Girard-Blanc; Gurdyal S Besra; Alain J Cozzone; Jean-François Prost
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis.
Biochemistry 2003;42(51):15300-9.
2003: Rosalind A Wilson; Sonia Rai; William N Maughan; Laurent Kremer; Benson M Kariuki; Kenneth D M Harris; Trixie Wagner; Gurdyal S Besra; Klaus Fütterer
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2303-5.
2003: Yann Guérardel; Emmanuel Maes; Volker Briken; Frédéric Chirat; Yves Leroy; Camille Locht; Gérard Strecker; Laurent Kremer
Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties.
The Journal of biological chemistry 2003;278(38):36637-51.
2003: Virginie Molle; Christine Girard-Blanc; Laurent Kremer; Patricia Doublet; Alain J Cozzone; Jean-François Prost
Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis.
Biochemical and biophysical research communications 2003;308(4):820-5.
2003: Cécile Vignal; Yann Guérardel; Laurent Kremer; Maryse Masson; Dominique Legrand; Joel Mazurier; Elisabeth Elass
Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):2014-23.
2003: Laurent Kremer; Lynn Dover; HECTOR MORBIDONI; Catherine Vilchèze; William N Maughan; Alain Baulard; Shiao-Chun Tu; Nadine Honoré; Vojo Deretic; James C Sacchettini; Camille Locht; William R. Jacobs Jr.; Gurdyal S Besra
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.
The Journal of biological chemistry 2003;278(23):20547-54.
2003: Franck Biet; Laurent Kremer; Isabelle Wolowczuk; Myriam Delacre; Camille Locht
Immune response induced by recombinant Mycobacterium bovis BCG producing the cholera toxin B subunit.
Infection and immunity 2003;71(5):2933-7.
2002: Franck Biet; Laurent Kremer; Isabelle Wolowczuk; Myriam Delacre; Camille Locht
Mycobacterium bovis BCG producing interleukin-18 increases antigen-specific gamma interferon production in mice.
Infection and immunity 2002;70(12):6549-57.
2002: Michelle H. Larsen; Catherine Vilchèze; Laurent Kremer; Gurdyal S Besra; Linda Parsons; Max Salfinger; Leonid Heifets; Manzour H Hazbon; David Alland; James C Sacchettini; William R. Jacobs Jr.
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.
Molecular microbiology 2002;46(2):453-66.
2002: Laurent Kremer; Yann Guérardel; Sudagar S Gurcha; Camille Locht; Gurdyal S Besra
Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile.
Microbiology (Reading, England) 2002;148(Pt 10):3145-54.
2002: Yann Guerardel; Emmanuel Maes; Elisabeth Elass; Yves Leroy; Philippe Timmerman; Gurdyal S Besra; Camille Locht; Gérard Strecker; Laurent Kremer
Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.
The Journal of biological chemistry 2002;277(34):30635-48.
2002: Laurent Kremer; Gurdyal S Besra
Current status and future development of antitubercular chemotherapy.
Expert opinion on investigational drugs 2002;11(8):1033-49.
2002: Sudagar S Gurcha; Alain Baulard; Laurent Kremer; Camille Locht; D Branch Moody; Walter Muhlecker; Catherine E Costello; Dean Crick; Patrick J Brennan; Gurdyal S Besra
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis.
The Biochemical journal 2002;365(Pt 2):441-50.
2002: Laurent Kremer; Lynn Dover; Séverine Carrère; K Madhavan Nampoothiri; Sarah Lesjean; Alistair K Brown; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.
The Biochemical journal 2002;364(Pt 2):423-30.
2002: David E Minnikin; Laurent Kremer; Lynn Dover; Gurdyal S Besra
The methyl-branched fortifications of Mycobacterium tuberculosis.
Chemistry & biology 2002;9(5):545-53.
2002: Laurent Kremer; Sudagar S Gurcha; Pablo Bifani; Paul G Hitchen; Alain Baulard; Howard R Morris; Anne Dell; Patrick J Brennan; Gurdyal S Besra
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis.
The Biochemical journal 2002;363(Pt 3):437-47.
2002: Franck Biet; Camille Locht; Laurent Kremer
Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens.
Journal of molecular medicine (Berlin, Germany) 2002;80(3):147-62.
2002: Laurent Kremer; Gurdyal S Besra
Re-emergence of tuberculosis: strategies and treatment.
Expert opinion on investigational drugs 2002;11(2):153-7.
2002: Laurent Kremer; William N Maughan; Rosalind A Wilson; Lynn Dover; Gurdyal S Besra
The M. tuberculosis antigen 85 complex and mycolyltransferase activity.
Letters in applied microbiology 2002;34(4):233-7.
2001: Laurent Kremer; K Madhavan Nampoothiri; Sarah Lesjean; Lynn Dover; S Graham; J Betts; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.
The Journal of biological chemistry 2001;276(30):27967-74.
2001: Laurent Kremer; Lynn Dover; Caroline Morehouse; P Hitchin; M Everett; Howard R Morris; Anne Dell; Patrick J Brennan; M R McNeil; C Flaherty; K Duncan; Gurdyal S Besra
Galactan biosynthesis in Mycobacterium tuberculosis. Identification of a bifunctional UDP-galactofuranosyltransferase.
The Journal of biological chemistry 2001;276(28):26430-40.
2001: L Dupré; Laurent Kremer; Isabelle Wolowczuk; Gilles Riveau; André Capron; Camille Locht
Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection.
Vaccine 2001;19(11-12):1373-80.
2000: K H Choi; Laurent Kremer; G S Besra; Charles O Rock
Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(36):28201-7.
2000: O Billaut-Mulot; T Idziorek; Elisabeth Ban; Laurent Kremer; L Dupré; M Loyens; Gilles Riveau; Camille Locht; André Capron; George M Bahr
Interleukin-18 modulates immune responses induced by HIV-1 Nef DNA prime/protein boost vaccine.
Vaccine 2000;19(1):95-102.
2000: Laurent Kremer; J Estaquier; Isabelle Wolowczuk; Franck Biet; J C Ameisen; Camille Locht
Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice.
Infection and immunity 2000;68(7):4264-73.
2000: Laurent Kremer; James D Douglas; Alain Baulard; Caroline Morehouse; M R Guy; DAvid Alland; Lynn Dover; Jeremy H Lakey; William R. Jacobs Jr.; Patrick J Brennan; David E Minnikin; Gurdyal S Besra
Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.
The Journal of biological chemistry 2000;275(22):16857-64.
1999: B Abomoelak; K Huygen; Laurent Kremer; M Turneer; Camille Locht
Humoral and cellular immune responses in mice immunized with recombinant Mycobacterium bovis Bacillus Calmette-Guérin producing a pertussis toxin-tetanus toxin hybrid protein.
Infection and immunity 1999;67(10):5100-5.
1999: Laurent Kremer; L Dupré; Isabelle Wolowczuk; Camille Locht
In vivo immunomodulation following intradermal injection with DNA encoding IL-18.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3226-31.
1998: Laurent Kremer; L Dupré; Gilles Riveau; André Capron; Camille Locht
Systemic and mucosal immune responses after intranasal administration of recombinant Mycobacterium bovis bacillus Calmette-Guérin expressing glutathione S-transferase from Schistosoma haematobium.
Infection and immunity 1998;66(12):5669-76.
1997: Laurent Kremer; Jérôme Estaquier; E Brandt; Jean-Claude Ameisen; Camille Locht
Mycobacterium bovis Bacillus Calmette Guérin infection prevents apoptosis of resting human monocytes.
European journal of immunology 1997;27(9):2450-6.
1996: Alain Baulard; Laurent Kremer; P Supply; D Vidaud; J M Bidart; D Bellet; Camille Locht
A new series of mycobacterial expression vectors for the development of live recombinant vaccines.
Gene 1996;176(1-2):149-54.
1996: Laurent Kremer; Gilles Riveau; Alain Baulard; André Capron; Camille Locht
Neutralizing antibody responses elicited in mice immunized with recombinant bacillus Calmette-Guérin producing the Schistosoma mansoni glutathione S-transferase.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(11):4309-17.
1996: Alain Baulard; Laurent Kremer; Camille Locht
Efficient homologous recombination in fast-growing and slow-growing mycobacteria.
Journal of bacteriology 1996;178(11):3091-8.
1995: Laurent Kremer; Alain Baulard; Jérôme Estaquier; POULAIN-GODEFROY Odile; Camille Locht
Green fluorescent protein as a new expression marker in mycobacteria.
Molecular microbiology 1995;17(5):913-22.
1995: Alain Baulard; V Escuyer; N Haddad; Laurent Kremer; Camille Locht; P Berche
Mercury resistance as a selective marker for recombinant mycobacteria.
Microbiology (Reading, England) 1995;141 ( Pt 4)():1045-50.
1995: Laurent Kremer; Alain Baulard; Jérôme Estaquier; J Content; André Capron; Camille Locht
Analysis of the Mycobacterium tuberculosis 85A antigen promoter region.
Journal of bacteriology 1995;177(3):642-53.
1992: A Scheirle; B Takacs; Laurent Kremer; F Marin; F Sinigaglia
Peptide binding to soluble HLA-DR4 molecules produced by insect cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):1994-9.