Nicholas Dean

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Sisco Mark; Kryger Zol B; O'Shaughnessy Kristina D; Kim Peter S; Schultz Greg S; Ding Xian-Zhong; Roy Nakshatra K; Dean Nicholas M; Mustoe Thomas A
Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo.
Graff Jeremy R; Konicek Bruce W; Vincent Thomas M; Lynch Rebecca L; Monteith David; Weir Spring N; Schwier Phil; Capen Andrew; Goode Robin L; Dowless Michele S; Chen Yuefeng; Zhang Hong; Sissons Sean; Cox Karen; McNulty Ann M; Parsons Stephen H; Wang Tao; Sams Lillian; Geeganage Sandaruwan; Douglass Larry E; Neubauer Blake Lee; Dean Nicholas M; Blanchard Kerry; Shou Jianyong; Stancato Louis F; Carter Julia H; Marcusson Eric G
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
Kim Youngsoo; Yoon Joon Won; Xiao Xiaokun; Dean Nicholas M; Monia Brett P; Marcusson Eric G
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.

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All Publications

2008: Sisco Mark; Kryger Zol B; O'Shaughnessy Kristina D; Kim Peter S; Schultz Greg S; Ding Xian-Zhong; Roy Nakshatra K; Dean Nicholas M; Mustoe Thomas A
Antisense inhibition of connective tissue growth factor (CTGF/CCN2) mRNA limits hypertrophic scarring without affecting wound healing in vivo.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2008;16(5):661-73.
2007: Graff Jeremy R; Konicek Bruce W; Vincent Thomas M; Lynch Rebecca L; Monteith David; Weir Spring N; Schwier Phil; Capen Andrew; Goode Robin L; Dowless Michele S; Chen Yuefeng; Zhang Hong; Sissons Sean; Cox Karen; McNulty Ann M; Parsons Stephen H; Wang Tao; Sams Lillian; Geeganage Sandaruwan; Douglass Larry E; Neubauer Blake Lee; Dean Nicholas M; Blanchard Kerry; Shou Jianyong; Stancato Louis F; Carter Julia H; Marcusson Eric G
Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity.
The Journal of clinical investigation 2007;117(9):2638-48.
2007: Kim Youngsoo; Yoon Joon Won; Xiao Xiaokun; Dean Nicholas M; Monia Brett P; Marcusson Eric G
Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells.
Cancer research 2007;67(8):3583-93.
2006: Bonness Kathy; Aragon Ileana V; Rutland Beth; Ofori-Acquah Solomon; Dean Nicholas M; Honkanen Richard E
Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha.
Molecular cancer therapeutics 2006;5(11):2727-36.
2006: Carter Bing Z; Mak Duncan H; Shi Yuexi; Schober Wendy D; Wang Rui-Yu; Konopleva Marina; Koller Erich; Dean Nicholas M; Andreeff Michael
Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance.
Cell cycle (Georgetown, Tex.) 2006;5(19):2223-9.
2006: Perera Ranjan J; Koo Seongjoon; Bennett C Frank; Dean Nicholas M; Gupta Nitin; Qin Jian-Zhong; Nickoloff Brian J
Defining the transcriptome of accelerated and replicatively senescent keratinocytes reveals links to differentiation, interferon signaling, and Notch related pathways.
Journal of cellular biochemistry 2006;98(2):394-408.
2006: Vickers Timothy A; Zhang Hong; Graham Mark J; Lemonidis Kristina M; Zhao Chenguang; Dean Nicholas M
Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(6):3652-61.
2006: Perera Ranjan J; Marcusson Eric G; Koo Seongjoon; Kang Xiaolin; Kim Youngsoo; White Neill; Dean Nicholas M
Identification of novel PPARgamma target genes in primary human adipocytes.
Gene 2006;369():90-9.
2006: Koller Erich; Propp Stephanie; Zhang Hong; Zhao Chenguang; Xiao Xiaokun; Chang MingYi; Hirsch Scott A; Shepard Peter J; Koo Seongjoon; Murphy Cain; Glazer Robert I; Dean Nicholas M
Use of a chemically modified antisense oligonucleotide library to identify and validate Eg5 (kinesin-like 1) as a target for antineoplastic drug development.
Cancer research 2006;66(4):2059-66.
2006: Koller Erich; Propp Stephanie; Murray Heather; Lima Walter; Bhat Balkrishen; Prakash Thaza P; Allerson Charles R; Swayze Eric E; Marcusson Eric G; Dean Nicholas M
Competition for RISC binding predicts in vitro potency of siRNA.
Nucleic acids research 2006;34(16):4467-76.
2005: Zhang Ji; Bao Shideng; Furumai Ryohei; Kucera Katerina S; Ali Ambereen; Dean Nicolas M; Wang Xiao-Fan
Protein phosphatase 5 is required for ATR-mediated checkpoint activation.
Molecular and cellular biology 2005;25(22):9910-9.
2005: Gysin Stephan; Lee Sang-Hyun; Dean Nicholas M; McMahon Martin
Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1.
Cancer research 2005;65(11):4870-80.
2004: Esau Christine; Kang Xiaolin; Peralta Eigen; Hanson Elaine; Marcusson Eric G; Ravichandran Lingamanaidu V; Sun Yingqing; Koo Seongjoon; Perera Ranjan J; Jain Ravi; Dean Nicholas M; Freier Susan M; Bennett C Frank; Lollo Bridget; Griffey Richard
MicroRNA-143 regulates adipocyte differentiation.
The Journal of biological chemistry 2004;279(50):52361-5.
2004: Golden Teresa; Aragon Ileana V; Zhou Guofei; Cooper Scott R; Dean Nicholas M; Honkanen Richard E
Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice.
Cancer letters 2004;215(1):95-100.
2004: Henry Scott P; Marcusson Eric G; Vincent Thomas M; Dean Nicholas M
Setting sights on the treatment of ocular angiogenesis using antisense oligonucleotides.
Trends in pharmacological sciences 2004;25(10):523-7.
2004: Gray Phillip J; Bearss David J; Han Haiyong; Nagle Raymond; Tsao Ming-Sound; Dean Nicholas; Von Hoff Daniel D
Identification of human polo-like kinase 1 as a potential therapeutic target in pancreatic cancer.
Molecular cancer therapeutics 2004;3(5):641-6.
2004: Ali Ambereen; Zhang Ji; Bao Shideng; Liu Irene; Otterness Diane; Dean Nicholas M; Abraham Robert T; Wang Xiao-Fan
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
Genes & development 2004;18(3):249-54.
2004: Uchio Kozue; Graham Mark; Dean Nicholas M; Rosenbaum Jean; Desmoulière Alexis
Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2004;12(1):60-6.
2004: Sun Yingqing; Koo Seongjoon; White Neill; Peralta Eigen; Esau Christine; Dean Nicholas M; Perera Ranjan J
Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs.
Nucleic acids research 2004;32(22):e188.
2004: Ravichandran Lingamanaidu V; Dean Nicholas M; Marcusson Eric G
Use of antisense oligonucleotides in functional genomics and target validation.
Oligonucleotides 2004;14(1):49-64.
2003: Dean Nicholas M; Bennett C Frank
Antisense oligonucleotide-based therapeutics for cancer.
Oncogene 2003;22(56):9087-96.
2003: Daniels Julie T; Schultz Gregory S; Blalock Timothy D; Garrett Qian; Grotendorst Gary R; Dean Nicholas M; Khaw Peng T
Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring.
The American journal of pathology 2003;163(5):2043-52.
2003: Carter B Z; Milella M; Tsao T; McQueen T; Schober W D; Hu W; Dean N M; Steelman L; McCubrey J A; Andreeff M
Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(11):2081-9.
2003: Zhang Hong; Taylor Jennifer; Luther Doreen; Johnston Joe; Murray Susan; Wyatt Jacqueline R; Watt Andrew T; Koo Seongjoon; York-DeFalco Cathie; Stecker Kimberly; Dean Nicholas M
Antisense oligonucleotide inhibition of Bcl-xL and Bid expression in liver regulates responses in a mouse model of Fas-induced fulminant hepatitis.
The Journal of pharmacology and experimental therapeutics 2003;307(1):24-33.
2003: Urban Gudrun; Golden Teresa; Aragon Ileana V; Cowsert Lex; Cooper Scott R; Dean Nicholas M; Honkanen Richard E
Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression.
The Journal of biological chemistry 2003;278(11):9747-53.
2003: Vickers Timothy A; Koo Seongjoon; Bennett C Frank; Crooke Stanley T; Dean Nicholas M; Baker Brenda F
Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis.
The Journal of biological chemistry 2003;278(9):7108-18.
2003: Yang Yong-Min; Bost Frédéric; Charbono Wilfried; Dean Nicholas; McKay Robert; Rhim Johng S; Depatie Chantal; Mercola Dan
C-Jun NH(2)-terminal kinase mediates proliferation and tumor growth of human prostate carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):391-401.
2003: Cordeiro M F; Mead A; Ali R R; Alexander R A; Murray S; Chen C; York-Defalco C; Dean N M; Schultz G S; Khaw P T
Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome.
Gene therapy 2003;10(1):59-71.
2003: Patel Niketa A; Eichler Duane C; Chappell David S; Illingworth Philip A; Chalfant Charles E; Yamamoto Mayumi; Dean Nicholas M; Wyatt Jacqueline R; Mebert Konrad; Watson James E; Cooper Denise R
The protein kinase C beta II exon confers mRNA instability in the presence of high glucose concentrations.
The Journal of biological chemistry 2003;278(2):1149-57.
2003: Chen Zongyou; Lu Lina; Zhang Hong; Dean Nicholas M; Fung John J; Qian Shiguang
Administration of antisense oligodeoxyribonucleotides targeting NF-kappaB prolongs allograft survival via suppression of cytotoxicity.
Microsurgery 2003;23(5):494-7.
2002: Ranganathan Gouri; Song Wei; Dean Nicholas; Monia Brett; Barger Steven W; Kern Philip A
Regulation of lipoprotein lipase by protein kinase C alpha in 3T3-F442A adipocytes.
The Journal of biological chemistry 2002;277(41):38669-75.
2002: Derenne Sophie; Monia Brett; Dean Nicholas M; Taylor Jennifer K; Rapp Marie-Josée; Harousseau Jean-Luc; Bataille Régis; Amiot Martine
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.
Blood 2002;100(1):194-9.
2002: Lee Yoon-Jin; Soh Jae-Won; Dean Nicholas M; Cho Chul-Koo; Kim Tae-Hwan; Lee Su-Jae; Lee Yun-Sil
Protein kinase Cdelta overexpression enhances radiation sensitivity via extracellular regulated protein kinase 1/2 activation, abolishing the radiation-induced G(2)-M arrest.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2002;13(5):237-46.
2002: Pan Bin; Yao Kang Shen; Monia Brett P; Dean Nicholas M; McKay Robert A; Hamilton Thomas C; O'Dwyer Peter J
Reversal of cisplatin resistance in human ovarian cancer cell lines by a c-jun antisense oligodeoxynucleotide (ISIS 10582): evidence for the role of transcription factor overexpression in determining resistant phenotype.
Biochemical pharmacology 2002;63(9):1699-707.
2002: Butler Madeline; McKay Robert A; Popoff Ian J; Gaarde William A; Witchell Donna; Murray Susan F; Dean Nicholas M; Bhanot Sanjay; Monia Brett P
Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice.
Diabetes 2002;51(4):1028-34.
2002: Kuss Bryone J; Corbo Margherita; Lau Wen Min; Fennell Dean A; Dean Nicholas M; Cotter Finbarr E
In vitro and in vivo downregulation of MRP1 by antisense oligonucleotides: a potential role in neuroblastoma therapy.
International journal of cancer. Journal international du cancer 2002;98(1):128-33.
2002: Broome H Elizabeth; Yu Alice L; Diccianni Mitch; Camitta Bruce M; Monia Brett P; Dean Nicholas M
Inhibition of Bcl-xL expression sensitizes T-cell acute lymphoblastic leukemia cells to chemotherapeutic drugs.
Leukemia research 2002;26(3):311-6.
2002: Golden Teresa; Dean Nicholas M; Honkanen Richard E
Use of antisense oligonucleotides: advantages, controls, and cardiovascular tissue.
Microcirculation (New York, N.Y. : 1994) 2002;9(1):51-64.
2002: Hua X-Y; Moore A; Malkmus S; Murray S F; Dean N; Yaksh T L; Butler M
Inhibition of spinal protein kinase Calpha expression by an antisense oligonucleotide attenuates morphine infusion-induced tolerance.
Neuroscience 2002;113(1):99-107.
2001: Dean N M
Functional genomics and target validation approaches using antisense oligonucleotide technology.
Current opinion in biotechnology 2001;12(6):622-5.
2001: Higuchi H; Miyoshi H; Bronk S F; Zhang H; Dean N; Gores G J
Bid antisense attenuates bile acid-induced apoptosis and cholestatic liver injury.
The Journal of pharmacology and experimental therapeutics 2001;299(3):866-73.
2001: Zhang H; Dean N M
Oligonucleotide inhibition of Fas as a potential treatment strategy in human liver disease.
Drug news & perspectives 2001;14(8):453-9.
2001: Brough G H; Wu S; Cioffi D; Moore T M; Li M; Dean N; Stevens T
Contribution of endogenously expressed Trp1 to a Ca2+-selective, store-operated Ca2+ entry pathway.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(10):1727-38.
2001: Urban G; Golden T; Aragon I V; Scammell J G; Dean N M; Honkanen R E
Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively.
The Journal of biological chemistry 2001;276(29):27638-46.
2001: Patel N A; Chalfant C E; Watson J E; Wyatt J R; Dean N M; Eichler D C; Cooper D R
Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinase-dependent pathway involving the nuclear serine/arginine-rich splicing factor, SRp40, in skeletal muscle cells.
The Journal of biological chemistry 2001;276(25):22648-54.
2001: Gottschalk A R; Basila D; Wong M; Dean N M; Brandts C H; Stokoe D; Haas-Kogan D A
p27Kip1 is required for PTEN-induced G1 growth arrest.
Cancer research 2001;61(5):2105-11.
2001: Fennell D A; Corbo M V; Dean N M; Monia B P; Cotter F E
In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model.
British journal of haematology 2001;112(3):706-13.
2001: Yu R Z; Zhang H; Geary R S; Graham M; Masarjian L; Lemonidis K; Crooke R; Dean N M; Levin A A
Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.
The Journal of pharmacology and experimental therapeutics 2001;296(2):388-95.
2001: Dean D A; Urban G; Aragon I V; Swingle M; Miller B; Rusconi S; Bueno M; Dean N M; Honkanen R E
Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling.
BMC cell biology 2001;2():6.
2000: Flynn P; Wongdagger M; Zavar M; Dean N M; Stokoe D
Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival.
Current biology : CB 2000;10(22):1439-42.
2000: Karras J G; McKay R A; Lu T; Dean N M; Monia B P
Antisense inhibition of membrane-bound human interleukin-5 receptor-alpha chain does not affect soluble receptor expression and induces apoptosis in TF-1 cells.
Antisense & nucleic acid drug development 2000;10(5):347-57.
2000: Taylor V; Wong M; Brandts C; Reilly L; Dean N M; Cowsert L M; Moodie S; Stokoe D
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Molecular and cellular biology 2000;20(18):6860-71.
2000: Zhang H; Cook J; Nickel J; Yu R; Stecker K; Myers K; Dean N M
Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis.
Nature biotechnology 2000;18(8):862-7.
2000: Karras J G; McKay R A; Dean N M; Monia B P
Deletion of individual exons and induction of soluble murine interleukin-5 receptor-alpha chain expression through antisense oligonucleotide-mediated redirection of pre-mRNA splicing.
Molecular pharmacology 2000;58(2):380-7.
2000: Potapova O; Gorospe M; Bost F; Dean N M; Gaarde W A; Mercola D; Holbrook N J
c-Jun N-terminal kinase is essential for growth of human T98G glioblastoma cells.
The Journal of biological chemistry 2000;275(32):24767-75.
2000: Karras J G; McGraw K; McKay R A; Cooper S R; Lerner D; Lu T; Walker C; Dean N M; Monia B P
Inhibition of antigen-induced eosinophilia and late phase airway hyperresponsiveness by an IL-5 antisense oligonucleotide in mouse models of asthma.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5409-15.
2000: Rosen K; Rak J; Leung T; Dean N M; Kerbel R S; Filmus J
Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells.
The Journal of cell biology 2000;149(2):447-56.
2000: Potapova O; Gorospe M; Dougherty R H; Dean N M; Gaarde W A; Holbrook N J
Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner.
Molecular and cellular biology 2000;20(5):1713-22.
2000: Myers K J; Dean N M
Sensible use of antisense: how to use oligonucleotides as research tools.
Trends in pharmacological sciences 2000;21(1):19-23.
2000: Cheng A; Dean N M; Honkanen R E
Serine/threonine protein phosphatase type 1gamma1 is required for the completion of cytokinesis in human A549 lung carcinoma cells.
The Journal of biological chemistry 2000;275(3):1846-54.
2000: Bost F; McKay R; Dean N M; Potapova O; Mercola D
Antisense methods for discrimination of phenotypic properties of closely related gene products: Jun kinase family.
Methods in enzymology 2000;314():342-62.
1999: Taylor J K; Zhang Q Q; Wyatt J R; Dean N M
Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides.
Nature biotechnology 1999;17(11):1097-100.
1999: Marcusson E G; Yacyshyn B R; Shanahan W R; Dean N M
Preclinical and clinical pharmacology of antisense oligonucleotides.
Molecular biotechnology 1999;12(1):1-11.
1999: Ferguson P J; Collins O; Dean N M; DeMoor J; Li C S; Vincent M D; Koropatnick J
Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.
British journal of pharmacology 1999;127(8):1777-86.
1999: Taylor J K; Zhang Q Q; Monia B P; Marcusson E G; Dean N M
Inhibition of Bcl-xL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli.
Oncogene 1999;18(31):4495-504.
1999: Zuo Z; Urban G; Scammell J G; Dean N M; McLean T K; Aragon I; Honkanen R E
Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest.
Biochemistry 1999;38(28):8849-57.
1999: Cooper S R; Taylor J K; Miraglia L J; Dean N M
Pharmacology of antisense oligonucleotide inhibitors of protein expression.
Pharmacology & therapeutics 1999;82(2-3):427-35.
1999: Taylor J K; Dean N M
Regulation of pre-mRNA splicing by antisense oligonucleotides.
Current opinion in drug discovery & development 1999;2(2):147-51.
1999: Jobbagy Z; Olah Z; Petrovics G; Eiden M V; Leverett B D; Dean N M; Anderson W B
Up-regulation of the Pit-2 phosphate transporter/retrovirus receptor by protein kinase C epsilon.
The Journal of biological chemistry 1999;274(11):7067-71.
1999: Bost F; McKay R; Bost M; Potapova O; Dean N M; Mercola D
The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells.
Molecular and cellular biology 1999;19(3):1938-49.
1999: Shen L; Dean N M; Glazer R I
Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide.
Molecular pharmacology 1999;55(2):396-402.
1999: McKay R A; Miraglia L J; Cummins L L; Owens S R; Sasmor H; Dean N M
Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression.
The Journal of biological chemistry 1999;274(3):1715-22.
1998: Alahari S K; DeLong R; Fisher M H; Dean N M; Viliet P; Juliano R L
Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression.
The Journal of pharmacology and experimental therapeutics 1998;286(1):419-28.
1998: Dennis J U; Dean N M; Bennett C F; Griffith J W; Lang C M; Welch D R
Human melanoma metastasis is inhibited following ex vivo treatment with an antisense oligonucleotide to protein kinase C-alpha.
Cancer letters 1998;128(1):65-70.
1998: Zuo Z; Dean N M; Honkanen R E
Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest.
The Journal of biological chemistry 1998;273(20):12250-8.
1998: Dean N M; McKay R A; Holmlund J
Antisense oligonucleotides as inhibitors of genes that regulate AP-1: pharmacology and clinical development.
Antisense & nucleic acid drug development 1998;8(2):147-51.
1998: Marcusson E G; Bhat B; Manoharan M; Bennett C F; Dean N M
Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus.
Nucleic acids research 1998;26(8):2016-23.
1998: Geiger T; Müller M; Dean N M; Fabbro D
Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard chemotherapeutic agents against various human tumors transplanted into nude mice.
Anti-cancer drug design 1998;13(1):35-45.
1997: Bost F; McKay R; Dean N; Mercola D
The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.
The Journal of biological chemistry 1997;272(52):33422-9.
1997: Traub O; Monia B P; Dean N M; Berk B C
PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells.
The Journal of biological chemistry 1997;272(50):31251-7.
1997: McGraw K; McKay R; Miraglia L; Boggs R T; Pribble J P; Muller M; Geiger T; Fabbro D; Dean N M
Antisense oligonucleotide inhibitors of isozymes of protein kinase C: in vitro and in vivo activity, and clinical development as anti-cancer therapeutics.
Anti-cancer drug design 1997;12(5):315-26.
1997: Dean N M; Griffey R H
Identification and characterization of second-generation antisense oligonucleotides.
Antisense & nucleic acid drug development 1997;7(3):229-33.
1997: Liao D F; Monia B; Dean N; Berk B C
Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(10):6146-50.
1997: Levesque L; Dean N M; Sasmor H; Crooke S T
Antisense oligonucleotides targeting human protein kinase C-alpha inhibit phorbol ester-induced reduction of bradykinin-evoked calcium mobilization in A549 cells.
Molecular pharmacology 1997;51(2):209-16.
1997: Lee Y S; Dlugosz A A; McKay R; Dean N M; Yuspa S H
Definition by specific antisense oligonucleotides of a role for protein kinase C alpha in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes.
Molecular carcinogenesis 1997;18(1):44-53.
1996: Alahari S K; Dean N M; Fisher M H; Delong R; Manoharan M; Tivel K L; Juliano R L
Inhibition of expression of the multidrug resistance-associated P-glycoprotein of by phosphorothioate and 5' cholesterol-conjugated phosphorothioate antisense oligonucleotides.
Molecular pharmacology 1996;50(4):808-19.
1996: Altmann K H; Fabbro D; Dean N M; Geiger T; Monia B P; Müller M; Nicklin P
Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors.
Biochemical Society transactions 1996;24(3):630-7.
1996: Dean N M; McKay R; Miraglia L; Geiger T; Müller M; Fabbro D; Bennett C F
Antisense oligonucleotides as inhibitors of signal transduction: development from research tools to therapeutic agents.
Biochemical Society transactions 1996;24(3):623-9.
1996: Dean N; McKay R; Miraglia L; Howard R; Cooper S; Giddings J; Nicklin P; Meister L; Ziel R; Geiger T; Muller M; Fabbro D
Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression.
Cancer research 1996;56(15):3499-507.
1996: Yazaki T; Ahmad S; Chahlavi A; Zylber-Katz E; Dean N M; Rabkin S D; Martuza R L; Glazer R I
Treatment of glioblastoma U-87 by systemic administration of an antisense protein kinase C-alpha phosphorothioate oligodeoxynucleotide.
Molecular pharmacology 1996;50(2):236-42.
1996: Miraglia L; Geiger T; Bennett C F; Dean N M
Inhibition of interleukin-1 type I receptor expression in human cell-lines by an antisense phosphorothioate oligodeoxynucleotide.
International journal of immunopharmacology 1996;18(4):227-40.
1996: Stewart A J; Canitrot Y; Baracchini E; Dean N M; Deeley R G; Cole S P
Reduction of expression of the multidrug resistance protein (MRP) in human tumor cells by antisense phosphorothioate oligonucleotides.
Biochemical pharmacology 1996;51(4):461-9.
1996: McKay R A; Cummins L L; Graham M J; Lesnik E A; Owens S R; Winniman M; Dean N M
Enhanced activity of an antisense oligonucleotide targeting murine protein kinase C-alpha by the incorporation of 2'-O-propyl modifications.
Nucleic acids research 1996;24(3):411-7.
1995: Dean N M; Boynton A L
EGF-induced increase in diacylglycerol, choline release, and DNA synthesis is extracellular calcium dependent.
Journal of cellular physiology 1995;164(3):449-58.
1994: Dean N M; McKay R
Inhibition of protein kinase C-alpha expression in mice after systemic administration of phosphorothioate antisense oligodeoxynucleotides.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11762-6.
1994: Dean N M; McKay R; Condon T P; Bennett C F
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.
The Journal of biological chemistry 1994;269(23):16416-24.
1991: Dean N M; Mordan L J; Tse K; Mooberry S L; Boynton A L
Okadaic acid inhibits PDGF-induced proliferation and decreases PDGF receptor number in C3H/10T1/2 mouse fibroblasts.
Carcinogenesis 1991;12(4):665-70.
1990: Boynton A L; Dean N M; Hill T D
Inositol 1,3,4,5-tetrakisphosphate and regulation of intracellular calcium.
Biochemical pharmacology 1990;40(9):1933-9.
1990: Hill T D; Boynton A L; Dean N M; Mordan L J
Retinyl acetate inhibits platelet-derived growth factor-induced Ca2+ signals in C3H 10T1/2 fibroblasts.
Journal of cellular physiology 1990;144(2):229-36.
1990: Dean N M; Boynton A L
Angiotensin II causes phosphatidylinositol turnover and increases 1,2-diacylglycerol mass but is not mitogenic in rat liver T51B cells.
The Biochemical journal 1990;269(2):347-52.
1990: Hill T D; Dean N M; Mordan L J; Lau A F; Kanemitsu M Y; Boynton A L
PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis.
Science (New York, N.Y.) 1990;248(4963):1660-3.
1990: Mordan L J; Dean N M; Honkanen R E; Boynton A L
Okadaic acid: a reversible inhibitor of neoplastic transformation of mouse fibroblasts.
Cancer communications 1990;2(7):237-41.
1989: Dean N M; Beaven M A
Methods for the analysis of inositol phosphates.
Analytical biochemistry 1989;183(2):199-209.
1989: Dean N M; Kanemitsu M; Boynton A L
Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells.
Biochemical and biophysical research communications 1989;165(2):795-801.
1988: Hill T D; Dean N M; Boynton A L
Inositol 1,3,4,5-tetrakisphosphate induces Ca2+ sequestration in rat liver cells.
Science (New York, N.Y.) 1988;242(4882):1176-8.
1988: Cunha-Melo J R; Dean N M; Ali H; Beaven M A
Formation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate from inositol 1,3,4,5-tetrakisphosphate and their pathways of degradation in RBL-2H3 cells.
The Journal of biological chemistry 1988;263(28):14245-50.
1988: Dean N M; Moyer J D
Metabolism of inositol bis-, tris-, tetrakis- and pentakis-phosphates in GH3 cells.
The Biochemical journal 1988;250(2):493-500.
1987: Cunha-Melo J R; Dean N M; Moyer J D; Maeyama K; Beaven M A
The kinetics of phosphoinositide hydrolysis in rat basophilic leukemia (RBL-2H3) cells varies with the type of IgE receptor cross-linking agent used.
The Journal of biological chemistry 1987;262(24):11455-63.
1987: Moyer J D; Reizes O; Dean N M; Malinowski N
D-myo-inositol (1,4)-bisphosphate 1-phosphate. Partial purification from rat liver and characterization.
Biochemical and biophysical research communications 1987;146(3):1018-26.
1987: Dean N M; Moyer J D
Separation of multiple isomers of inositol phosphates formed in GH3 cells.
The Biochemical journal 1987;242(2):361-6.

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