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Wouter Koek

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Wouter Koek; Kejun Cheng; Kenner C Rice
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
Lynette C Daws; Wouter Koek; Nathan C Mitchell
Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders.
David R Maguire; Wouter Koek; Jun-Xu Li; Charles France
Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys.

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All Publications

2013: Wouter Koek; Kejun Cheng; Kenner C Rice
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
The Journal of pharmacology and experimental therapeutics 2013;344(3):553-60.
2013: Lynette C Daws; Wouter Koek; Nathan C Mitchell
Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders.
ACS chemical neuroscience 2013;4(1):16-21.
2013: David R Maguire; Wouter Koek; Jun-Xu Li; Charles France
Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys.
Psychopharmacology 2013;225(1):173-85.
2012: Jun-Xu Li; Wouter Koek; Charles France
Interactions between Δ(9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys.
Behavioural pharmacology 2012;23(8):754-61.
2012: Michelle G Baladi; Wouter Koek; Fortino Velasco; Megan Aumann; Charles France
Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats.
Psychopharmacology 2012;222(3):447-57.
2012: Wouter Koek; Kejun Cheng; Charles France; Kenner C Rice
Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.
The Journal of pharmacology and experimental therapeutics 2012;341(2):369-76.
2012: Wouter Koek; Charles France; Martin A Javors
Morphine-induced motor stimulation, motor incoordination, and hypothermia in adolescent and adult mice.
Psychopharmacology 2012;219(4):1027-37.
2012: Julie Hensler; Kenner C Rice; Teresa F Burke; Kejun Cheng; Tushar Advani; Wouter Koek
GABAB receptor-positive modulators: brain region-dependent effects.
The Journal of pharmacology and experimental therapeutics 2012;340(1):19-26.
2011: Jun-Xu Li; Michelle G Baladi; Shutian Ju; Wouter Koek; Charles France
Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction.
Behavioural pharmacology 2011;22(8):751-7.
2011: Wouter Koek
Drug-induced state-dependent learning: review of an operant procedure in rats.
Behavioural pharmacology 2011;22(5-6):430-40.
2011: Jun-Xu Li; Wouter Koek; Kenner C Rice; Charles France
Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011;36(5):940-9.
2011: Jun-Xu Li; Caroline Crocker; Wouter Koek; Kenner C Rice; Charles France
Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies.
Psychopharmacology 2011;213(2-3):489-97.
2010: Marie-Bernadette Assié; Laurent Bardin; Agnès L Auclair; Elisabeth Carilla-Durand; Ronan Depoortère; Wouter Koek; Mark S Kleven; Francis Colpaert; Bernard Vacher; Adrian Newman-Tancredi
F15599, a highly selective post-synaptic 5-HT(1A) receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(10):1285-98.
2010: Wouter Koek; Charles France; Kejun Cheng; Kenner C Rice
GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.
The Journal of pharmacology and experimental therapeutics 2010;335(1):163-71.
2010: Jun-Xu Li; Wouter Koek; Kenner C Rice; Charles France
Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2010;333(1):244-52.
2010: Ginger L Becker; Lisa Gerak; Jun-Xu Li; Wouter Koek; Charles France
Precipitated and conditioned withdrawal in morphine-treated rats.
Psychopharmacology 2010;209(1):85-94.
2009: Jun-Xu Li; Alison Unzeitig; Martin A Javors; Kenner C Rice; Wouter Koek; Charles France
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats.
The Journal of pharmacology and experimental therapeutics 2009;331(2):671-9.
2009: Wouter Koek; Susan L Mercer; Andrew Coop; Charles France
Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348).
The Journal of pharmacology and experimental therapeutics 2009;330(3):876-83.
2009: Charles France; Jun-Xu Li; William A Owens; Wouter Koek; Glenn M Toney; Lynette Daws
Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(6):731-6.
2009: Jun-Xu Li; Wouter Koek; Charles France
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
European journal of pharmacology 2009;613(1-3):60-3.
2009: David A Price; Alex A Martinez; Alexandre Seillier; Wouter Koek; Yolanda Acosta; Elizabeth Fernandez; John Strong; Beat Lutz; Giovanni Marsicano; James Roberts; Andrea Giuffrida
WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
The European journal of neuroscience 2009;29(11):2177-86.
2009: Tushar Advani; Wouter Koek; Julie Hensler
Gender differences in the enhanced vulnerability of BDNF+/- mice to mild stress.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(5):583-8.
2009: Lawrence P Carter; Wouter Koek; Charles France
Behavioral analyses of GHB: receptor mechanisms.
Pharmacology & therapeutics 2009;121(1):100-14.
2008: Nicole L Baganz; Rebecca E Horton; Alfredo S Calderon; W Anthony Owens; Jaclyn L Munn; Lora T Watts; Nina Koldzic-Zivanovic; Nathaniel Jeske; Wouter Koek; Glenn M Toney; Lynette Daws
Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18976-81.
2008: G L Becker; Lisa Gerak; Wouter Koek; Charles France
Antagonist-precipitated and discontinuation-induced withdrawal in morphine-dependent rhesus monkeys.
Psychopharmacology 2008;201(3):373-82.
2008: Rajkumar J Sevak; Wouter Koek; W Anthony Owens; Aurelio Galli; Lynette Daws; Charles France
Feeding conditions differentially affect the neurochemical and behavioral effects of dopaminergic drugs in male rats.
European journal of pharmacology 2008;592(1-3):109-15.
2008: Wouter Koek; Charles France
Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists.
Psychopharmacology 2008;199(2):191-8.
2008: Rajkumar J Sevak; Wouter Koek; Lynette Daws; W Anthony Owens; Aurelio Galli; Charles France
Behavioral effects of amphetamine in streptozotocin-treated rats.
European journal of pharmacology 2008;581(1-2):105-12.
2007: Wouter Koek; Mandar Khanal; Charles France
Synergistic interactions between 'club drugs': gamma-hydroxybutyrate and phencyclidine enhance each other's discriminative stimulus effects.
Behavioural pharmacology 2007;18(8):807-10.
2007: Tushar Advani; Julie Hensler; Wouter Koek
Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2007;10(5):595-607.
2007: Sherin Y Boctor; Joe Martinez; Wouter Koek; Charles France
The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding.
European journal of pharmacology 2007;571(1):39-43.
2007: Lance McMahon; Wouter Koek
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
European journal of pharmacology 2007;569(1-2):70-6.
2007: Francis Colpaert; Wouter Koek; Mark S Kleven; Joel Besnard
Induction by antipsychotics of "win-shift" in the drug discrimination paradigm.
The Journal of pharmacology and experimental therapeutics 2007;322(1):288-98.
2007: Wouter Koek; Susan L Mercer; Andrew Coop
Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348.
Psychopharmacology 2007;192(3):407-14.
2007: Rajkumar J Sevak; W Anthony Owens; Wouter Koek; Aurelio Galli; Lynette Daws; Charles France
Evidence for D2 receptor mediation of amphetamine-induced normalization of locomotion and dopamine transporter function in hypoinsulinemic rats.
Journal of neurochemistry 2007;101(1):151-9.
2007: Laurent Bardin; Agnès Auclair; Mark S Kleven; Eric P M Prinssen; Wouter Koek; Adrian Newman-Tancredi; Ronan Depoortère
Pharmacological profiles in rats of novel antipsychotics with combined dopamine D2/serotonin 5-HT1A activity: comparison with typical and atypical conventional antipsychotics.
Behavioural pharmacology 2007;18(2):103-18.
2007: Rajkumar J Sevak; Wouter Koek; Aurelio Galli; Charles France
Insulin replacement restores the behavioral effects of quinpirole and raclopride in streptozotocin-treated rats.
The Journal of pharmacology and experimental therapeutics 2007;320(3):1216-23.
2006: Lawrence P Carter; Wouter Koek; Charles France
Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats.
The European journal of neuroscience 2006;24(9):2595-600.
2006: Elizabeth Fernandez; Wouter Koek; Qitao Ran; Greg A Gerhardt; Charles France; John Strong
Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice.
Alcoholism, clinical and experimental research 2006;30(10):1650-8.
2006: Charles France; Robert H Weltman; Wouter Koek; Christopher M Cruź; Lance McMahon
Acute and chronic effects of ramelteon in rhesus monkeys (Macaca mulatta): dependence liability studies.
Behavioral neuroscience 2006;120(3):535-41.
2006: Lawrence P Carter; Weibin Chen; Andrew Coop; Wouter Koek; Charles France
Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348.
European journal of pharmacology 2006;538(1-3):85-93.
2006: Wouter Koek; Lawrence P Carter; Huifang Wu; Andrew Coop; Charles France
Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone.
Behavioural pharmacology 2006;17(3):239-47.
2006: Wouter Koek; Weibin Chen; Susan L Mercer; Andrew Coop; Charles France
Discriminative stimulus effects of gamma-hydroxybutyrate: role of training dose.
The Journal of pharmacology and experimental therapeutics 2006;317(1):409-17.
2005: Marie-Bernadette Assié; Nathalie Consul-Denjean; Wouter Koek; Adrian Newman-Tancredi
Differential in vivo inhibition of [3H]nemonapride binding by atypical antipsychotics in rat striatum, olfactory lobes, and frontal cortex.
Pharmacology 2005;75(2):63-8.
2005: Rajkumar J Sevak; Wouter Koek; Charles France
Streptozotocin-induced diabetes differentially modifies haloperidol- and gamma-hydroxybutyric acid (GHB)-induced catalepsy.
European journal of pharmacology 2005;517(1-2):64-7.
2005: Wouter Koek; Lawrence P Carter; Richard J Lamb; Weibin Chen; Huifang Wu; Andrew Coop; Charles France
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam.
The Journal of pharmacology and experimental therapeutics 2005;314(1):170-9.
2005: Brett Ginsburg; Wouter Koek; Martin A Javors; Richard J Lamb
Effects of fluvoxamine on a multiple schedule of ethanol- and food-maintained behavior in two rat strains.
Psychopharmacology 2005;180(2):249-57.
2005: Lawrence P Carter; Huifang Wu; Weibin Chen; Marilyn M Matthews; Ashok K Mehta; R Jason Hernandez; Jennifer A Thomson; Maharaj K Ticku; Andrew Coop; Wouter Koek; Charles France
Novel gamma-hydroxybutyric acid (GHB) analogs share some, but not all, of the behavioral effects of GHB and GABAB receptor agonists.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1314-23.
2005: Lawrence P Carter; Weibin Chen; Huifang Wu; Ashok K Mehta; R Jason Hernandez; Maharaj K Ticku; Andrew Coop; Wouter Koek; Charles France
Comparison of the behavioral effects of gamma-hydroxybutyric acid (GHB) and its 4-methyl-substituted analog, gamma-hydroxyvaleric acid (GHV).
Drug and alcohol dependence 2005;78(1):91-9.
2005: Laurent Bardin; Marie-Bernadette Assié; Martine Pélissou; Isabelle Royer-Urios; Adrian Newman-Tancredi; Jean-Paul Ribet; François Sautel; Wouter Koek; Francis C Colpaert
Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: relationship with 5-HT1A receptor occupancy and kinetic parameters.
The Journal of pharmacology and experimental therapeutics 2005;312(3):1034-42.
2005: Stacy L Sell; Lance McMahon; Wouter Koek; Charles France
Monoaminergic drugs and directly observable signs of LAAM withdrawal in rhesus monkeys.
Behavioural pharmacology 2005;16(1):53-8.
2004: Lawrence P Carter; A W Unzeitig; Huifang Wu; Weibin Chen; Andrew Coop; Wouter Koek; Charles France
The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors.
The Journal of pharmacology and experimental therapeutics 2004;309(2):540-7.
2004: Eric P M Prinssen; Francis C Colpaert; Mark S Kleven; Wouter Koek
Ability of dopamine antagonists to inhibit the locomotor effects of cocaine in sensitized and non-sensitized C57BL/6 mice depends on the challenge dose.
Psychopharmacology 2004;172(4):409-14.
2004: Wouter Koek; Lauren R Flores; Lawrence P Carter; Richard J Lamb; Weibin Chen; Huifang Wu; Andrew Coop; Charles France
Discriminative stimulus effects of gamma-hydroxybutyrate in pigeons: role of diazepam-sensitive and -insensitive GABA(A) and GABA(B) receptors.
The Journal of pharmacology and experimental therapeutics 2004;308(3):904-11.
2004: Kary A Eckermann; Wouter Koek; Charles France
Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen.
European journal of pharmacology 2004;484(2-3):259-62.
2004: Cristina Cosi; Karen Guerin; Marc Marien; Wouter Koek; Karin Rollet
The PARP inhibitor benzamide protects against kainate and NMDA but not AMPA lesioning of the mouse striatum in vivo.
Brain research 2004;996(1):1-8.
2004: Rajkumar J Sevak; Charles France; Wouter Koek
Neuroleptic-like effects of gamma-hydroxybutyrate: interactions with haloperidol and dizocilpine.
European journal of pharmacology 2004;483(2-3):289-93.
2004: Lawrence P Carter; Huifang Wu; Weibin Chen; Christopher M Cruz; Richard J Lamb; Wouter Koek; Andrew Coop; Charles France
Effects of gamma-hydroxybutyrate (GHB) on schedule-controlled responding in rats: role of GHB and GABAB receptors.
The Journal of pharmacology and experimental therapeutics 2004;308(1):182-8.
2003: Wei-Ping Wu; Jing-Xia Hao; Xiao-Jun Xu; Zsuzsanna Wiesenfeld-Hallin; Wouter Koek; Francis C Colpaert
The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury.
European journal of pharmacology 2003;478(2-3):131-7.
2003: Kristof Deseure; Wouter Koek; Hugo Adriaensen; Francis C Colpaert
Continuous administration of the 5-hydroxytryptamine1A agonist (3-Chloro-4-fluoro-phenyl)-[4-fluoro-4-[[(5-methyl-pyridin-2-ylmethyl) -amino]-methyl]piperidin-1-yl]-methadone (F 13640) attenuates allodynia-like behavior in a rat model of trigeminal neuropathic pain.
The Journal of pharmacology and experimental therapeutics 2003;306(2):505-14.
2003: Richard J Lamb; Jaclyn L Munn; Nicklaus J Duiker; Andrew Coop; Huifang Wu; Wouter Koek; Charles France
Interactions of gamma-hydroxy butyrate with ethanol and NCS 382.
European journal of pharmacology 2003;470(3):157-62.
2003: Liesbeth A Bruins Slot; Wouter Koek; Jean-Pierre Tarayre; Francis C Colpaert
Tolerance and inverse tolerance to the hyperalgesic and analgesic actions, respectively, of the novel analgesic, F 13640.
European journal of pharmacology 2003;466(3):271-9.
2003: Laurent Bardin; Jean-Pierre Tarayre; N Malfetes; Wouter Koek; Francis C Colpaert
Profound, non-opioid analgesia produced by the high-efficacy 5-HT(1A) agonist F 13640 in the formalin model of tonic nociceptive pain.
Pharmacology 2003;67(4):182-94.
2002: Kristof Deseure; Wouter Koek; Francis C Colpaert; Hugo Adriaensen
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.
European journal of pharmacology 2002;456(1-3):51-7.
2002: Francis C Colpaert; Jean-Pierre Tarayre; Wouter Koek; Petrus J Pauwels; Laurent Bardin; X-J Xu; Z Wiesenfeld-Hallin; Cristina Cosi; Elisabeth Carilla-Durand; Marie-Bernadette Assié; Bernard Vacher
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Neuropharmacology 2002;43(6):945-58.
2002: Eric P M Prinssen; Francis C Colpaert; Wouter Koek
5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy.
European journal of pharmacology 2002;453(2-3):217-21.
2002: Liesbeth A Bruins Slot; Jean-Pierre Tarayre; Wouter Koek; Jean-Paul Ribet; Francis C Colpaert
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Pharmacology, biochemistry, and behavior 2002;72(4):943-51.
2002: Eric P M Prinssen; Marie-Bernadette Assié; Wouter Koek; Mark S Kleven
Depletion of 5-HT disrupts prepulse inhibition in rats: dependence on the magnitude of depletion, and reversal by a 5-HT precursor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;26(3):340-7.
2002: Petrus J Pauwels; Wouter Koek
Atypical kinetics for a series of putative dopamine antagonists to reverse the low-magnitude Ca2+ phase in the dopamine-bound D2short receptor state.
Naunyn-Schmiedeberg's archives of pharmacology 2002;365(1):82-5.
2001: Cristina Cosi; Wouter Koek
Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells.
European journal of pharmacology 2001;433(1):55-62.
2001: Francis C Colpaert; Wouter Koek; Liesbeth A Bruins Slot
Evidence that mnesic states govern normal and disordered memory.
Behavioural pharmacology 2001;12(8):575-89.
2001: Laurent Bardin; Jean-Pierre Tarayre; Wouter Koek; Francis C Colpaert
In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
European journal of pharmacology 2001;421(2):109-14.
2001: Wouter Koek; Bernard Vacher; Cristina Cosi; Marie-Bernadette Assié; Jean-François Patoiseau; Petrus J Pauwels; Francis C Colpaert
5-HT1A receptor activation and antidepressant-like effects: F 13714 has high efficacy and marked antidepressant potential.
European journal of pharmacology 2001;420(2-3):103-12.
2001: Francis C Colpaert; Jean-Pierre Tarayre; M Alliaga; Liesbeth A Bruins Slot; N Attal; Wouter Koek
Opiate self-administration as a measure of chronic nociceptive pain in arthritic rats.
Pain 2001;91(1-2):33-45.
2000: Francis C Colpaert; Liesbeth A Bruins Slot; Wouter Koek; DS Dupuis
Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent models.
Behavioural brain research 2000;117(1-2):41-51.
2000: Marie-Bernadette Assié; Wouter Koek
Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats.
European journal of pharmacology 2000;409(2):173-7.
2000: J Bergman; Charles France; S G Holtzman; J L Katz; Wouter Koek; Dai stephens
Agonist efficacy, drug dependence, and medications development: preclinical evaluation of opioid, dopaminergic, and GABAA-ergic ligands.
Psychopharmacology 2000;153(1):67-84.
2000: Cristina Cosi; Wouter Koek
The putative <> 5-HT(1A) receptor antagonist, WAY 100635, has inverse agonist properties at cloned human 5-HT(1A) receptors.
European journal of pharmacology 2000;401(1):9-15.
2000: Marie-Bernadette Assié; Wouter Koek
[(3)H]-8-OH-DPAT binding in the rat brain raphe area: involvement of 5-HT(1A) and non-5-HT(1A) receptors.
British journal of pharmacology 2000;130(6):1348-52.
2000: Eric P M Prinssen; Wouter Koek; Francis C Colpaert; Mark S Kleven
Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy.
Behavioural pharmacology 2000;11(3-4):299-305.
2000: Wouter Koek; Marie-Bernadette Assié; G Zernig; Charles France
In vivo estimates of efficacy at 5-HT1A receptors: effects of EEDQ on the ability of agonists to produce lower-lip retraction in rats.
Psychopharmacology 2000;149(4):377-87.
2000: Eric P M Prinssen; Wouter Koek; Mark S Kleven
Effects of WAY 100635 on antipsychotic-induced catalepsy in 5-HT depleted animals: a role for tonic activation of 5-HT(1A) receptors.
European journal of pharmacology 2000;395(2):143-7.
2000: Eric P M Prinssen; Wouter Koek; Mark S Kleven
The effects of antipsychotics with 5-HT(2C) receptor affinity in behavioral assays selective for 5-HT(2C) receptor antagonist properties of compounds.
European journal of pharmacology 2000;388(1):57-67.
1999: Marie-Bernadette Assié; Cristina Cosi; Wouter Koek
Correlation between low/high affinity ratios for 5-HT(1A) receptors and intrinsic activity.
European journal of pharmacology 1999;386(1):97-103.
1999: Wouter Koek
N-methyl-D-aspartate antagonists and drug discrimination.
Pharmacology, biochemistry, and behavior 1999;64(2):275-81.
1999: Mark S Kleven; Jean-Marc Kamenka; Jacques Vignon; Wouter Koek
Pharmacological characterization of the discriminative stimulus properties of the phencyclidine analog, N-[1-(2-benzo(b)thiophenyl)-cyclohexyl]piperidine.
Psychopharmacology 1999;145(4):370-7.
1999: Gareth W John; Petrus J Pauwels; Michel Perez; Serge Halazy; Bruno Le Grand; Yvan Verscheure; JP Valentin; Christiane Palmier; Thierry Wurch; Philippe Chopin; Marc Marien; Mark S Kleven; Wouter Koek; M B Assie; Elisabeth Carilla-Durand; Jean-Pierre Tarayre; Francis C Colpaert
F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine.
The Journal of pharmacology and experimental therapeutics 1999;290(1):83-95.
1999: Mark S Kleven; Wouter Koek
Effects of different classes of partial benzodiazepine agonists on punished and unpunished responding in pigeons.
Psychopharmacology 1999;144(4):405-10.
1999: Bernard Vacher; B Bonnaud; Philippe Funes; N Jubault; Wouter Koek; Marie-Bernadette Assié; Cristina Cosi; Mark S Kleven
Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors.
Journal of medicinal chemistry 1999;42(9):1648-60.
1999: Eric P M Prinssen; Mark S Kleven; Wouter Koek
Interactions between neuroleptics and 5-HT(1A) ligands in preclinical behavioral models for antipsychotic and extrapyramidal effects.
Psychopharmacology 1999;144(1):20-9.
1999: Liesbeth A Bruins Slot; Wouter Koek; Francis C Colpaert
Ethanol state dependence involving a lever press response requirement in rats.
Behavioural pharmacology 1999;10(2):229-33.
1999: Eric P M Prinssen; Wouter Koek; Jacques Vignon; Jean-Marc Kamenka; Mark S Kleven
Does crossing over repeated treatment with the dopamine reuptake inhibitors cocaine and BTCP modify their effects on cocaine-induced locomotion?
Psychopharmacology 1999;143(1):8-14.
1999: Mark S Kleven; Wouter Koek
Effects of benzodiazepine agonists on punished responding in pigeons and their relationship with clinical doses in humans.
Psychopharmacology 1999;141(2):206-12.
1998: Bernard Vacher; B Bonnaud; Philippe Funes; N Jubault; Wouter Koek; Marie-Bernadette Assié; Cristina Cosi
Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors.
Journal of medicinal chemistry 1998;41(25):5070-83.
1998: Wouter Koek; Jean-François Patoiseau; Marie-Bernadette Assié; Cristina Cosi; Mark S Kleven; Elisabeth Dupont-Passelaigue; Elisabeth Carilla-Durand; Christiane Palmier; JP Valentin; G John; Petrus J Pauwels; Jean-Pierre Tarayre; Francis C Colpaert
F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.
The Journal of pharmacology and experimental therapeutics 1998;287(1):266-83.
1998: Eric P M Prinssen; Mark S Kleven; Wouter Koek
The cataleptogenic effects of the neuroleptic nemonapride are attenuated by its 5-HT1A receptor agonist properties.
European journal of pharmacology 1998;356(2-3):189-92.
1998: Eric P M Prinssen; Wouter Koek; Mark S Kleven
Cocaine sensitization prevents the hypolocomotor effects of high but not low doses of PD 128,907.
European journal of pharmacology 1998;355(1):19-22.
1998: Mark S Kleven; Wouter Koek
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
The Journal of pharmacology and experimental therapeutics 1998;284(3):1015-25.
1998: Mark S Kleven; Wouter Koek
Discriminative stimulus effects of 8-hydroxy-2-(di-n-propylamino)tetralin in pigeons and rats: species similarities and differences.
The Journal of pharmacology and experimental therapeutics 1998;284(1):238-49.
1997: Cristina Cosi; H Suzuki; Stephen Skaper; D Milani; Laura Facci; M Menegazzi; G Vantini; Y Kanai; A Degryse; Francis Colpaert; Wouter Koek; Marc Marien
Poly(ADP-ribose) polymerase (PARP) revisited. A new role for an old enzyme: PARP involvement in neurodegeneration and PARP inhibitors as possible neuroprotective agents.
Annals of the New York Academy of Sciences 1997;825():366-79.
1997: Marie-Bernadette Assié; Cristina Cosi; Wouter Koek
5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine.
European journal of pharmacology 1997;334(2-3):141-7.
1997: Mark S Kleven; Marie-Bernadette Assié; Wouter Koek
Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats.
The Journal of pharmacology and experimental therapeutics 1997;282(2):747-59.
1997: Mark S Kleven; Wouter Koek
Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists.
Psychopharmacology 1997;131(3):307-12.
1997: Mark S Kleven; Wouter Koek
Dopamine D2 receptors play a role in the (-)-apomorphine-like discriminative stimulus effects of (+)-PD 128907.
European journal of pharmacology 1997;321(1):1-4.
1996: Mark S Kleven; Wouter Koek
Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys.
The Journal of pharmacology and experimental therapeutics 1996;279(3):1211-9.
1996: Eric P M Prinssen; Mark S Kleven; Wouter Koek
Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin.
Psychopharmacology 1996;128(2):191-7.
1996: Marie-Bernadette Assié; Wouter Koek
Possible in vivo 5-HT reuptake blocking properties of 8-OH-DPAT assessed by measuring hippocampal extracellular 5-HT using microdialysis in rats.
British journal of pharmacology 1996;119(5):845-50.
1996: Mark S Kleven; Eric P M Prinssen; Wouter Koek
Role of 5-HT1A receptors in the ability of mixed 5-HT1A receptor agonist/dopamine D2 receptor antagonists to inhibit methylphenidate-induced behaviors in rats.
European journal of pharmacology 1996;313(1-2):25-34.
1996: Cristina Cosi; F Colpaert; Wouter Koek; A Degryse; Marc Marien
Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice.
Brain research 1996;729(2):264-9.
1996: Marie-Bernadette Assié; Wouter Koek
Effects of 5-HT1A receptor antagonists on hippocampal 5-hydroxytryptamine levels: (S)-WAY100135, but not WAY100635, has partial agonist properties.
European journal of pharmacology 1996;304(1-3):15-21.
1996: Eric P M Prinssen; Mark S Kleven; Wouter Koek
Repeated administration of cocaethylene induces context-dependent sensitization to its locomotor effects.
Psychopharmacology 1996;124(4):300-5.
1996: Eric P M Prinssen; Mark S Kleven; Jacques Vignon; Jean-Marc Kamenka; Wouter Koek
Effects of repeated administration of N-[1-(2-benzo(b)-thiophenyl)cyclohexy]piperidine and cocaine on locomotor activity in C57BL/6 mice.
The Journal of pharmacology and experimental therapeutics 1996;276(3):904-11.
1996: M B Assie; Wouter Koek
(-)-pindolol and (+/-)-tertatolol affect rat hippocampal 5-HT levels through mechanisms involving not only 5-HT1A, but also 5-HT1B receptors.
Neuropharmacology 1996;35(2):213-22.
1996: Mark S Kleven; Wouter Koek
Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon.
The Journal of pharmacology and experimental therapeutics 1996;276(2):388-97.
1995: I Nevo; X Langlois; AM Laporte; M Kleven; Wouter Koek; L Lima; C Maudhuit; M P Martres; Michel Hamon
Chronic alcoholization alters the expression of 5-HT1A and 5-HT1B receptor subtypes in rat brain.
European journal of pharmacology 1995;281(3):229-39.
1995: Mark S Kleven; C Ybema; E Carilla; M Hamon; Wouter Koek
Modification of behavioral effects of 8-hydroxy-2-(di-n-propylamino)tetralin following chronic ethanol consumption in the rat: evidence for the involvement of 5-HT1A receptors in ethanol dependence.
European journal of pharmacology 1995;281(3):219-28.
1995: F C Colpaert; Wouter Koek
Empirical evidence that the state dependence and drug discrimination paradigms can generate different outcomes.
Psychopharmacology 1995;120(3):272-9.
1995: A Jackson; Wouter Koek; F C Colpaert
Can the DRL 72s schedule selectively reveal antidepressant drug activity?
Psychopharmacology 1995;117(2):154-61.
1993: Wouter Koek; F C Colpaert
Inhibition of methylphenidate-induced behaviors in rats: differences among neuroleptics.
The Journal of pharmacology and experimental therapeutics 1993;267(1):181-91.
1993: A J Sleight; Wouter Koek; D C Bigg
Binding of antipsychotic drugs at alpha 1A- and alpha 1B-adrenoceptors: risperidone is selective for the alpha 1B-adrenoceptors.
European journal of pharmacology 1993;238(2-3):407-10.
1993: Marie-Bernadette Assié; A J Sleight; Wouter Koek
Biphasic displacement of [3H]YM-09151-2 binding in the rat brain by thioridazine, risperidone and clozapine, but not by other antipsychotics.
European journal of pharmacology 1993;237(2-3):183-9.
1993: Wouter Koek; F C Colpaert; Jacques Vignon
Effects of phencyclidine-type drugs in rats discriminating fentanyl from saline: pharmacological and behavioral characterization of intermediate levels of drug lever selection.
The Journal of pharmacology and experimental therapeutics 1993;264(2):746-56.
1992: Wouter Koek; A Jackson; F C Colpaert
Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors.
Neuroscience and biobehavioral reviews 1992;16(1):95-105.
1991: Wouter Koek; F C Colpaert
Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: evaluation of N-methyl-D-aspartate antagonists.
Life sciences 1991;49(9):PL37-42.
1990: Wouter Koek; James H Woods; F C Colpaert
N-methyl-D-aspartate antagonism and phencyclidine-like activity: a drug discrimination analysis.
The Journal of pharmacology and experimental therapeutics 1990;253(3):1017-25.
1990: Wouter Koek; F C Colpaert
Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: relationship with phencyclidine-like behavioral effects.
The Journal of pharmacology and experimental therapeutics 1990;252(1):349-57.
1989: F C Colpaert; Wouter Koek; A Lategan
1-5-Hydroxytryptophan-induced flat body posture in the rat: antagonism by ritanserin and potentiation after 5,7-dihydroxytryptamine.
European journal of pharmacology 1989;169(1):175-8.
1989: Wouter Koek; F C Colpaert; James H Woods; Jean-Marc Kamenka
The phencyclidine (PCP) analog N-[1-(2-benzo(B)thiophenyl) cyclohexyl]piperidine shares cocaine-like but not other characteristic behavioral effects with PCP, ketamine and MK-801.
The Journal of pharmacology and experimental therapeutics 1989;250(3):1019-27.
1988: Wouter Koek; James H Woods
2-Amino-6-trifluoromethoxy benzothiazole (PK 26124), a proposed antagonist of excitatory amino acid neurotransmission, does not produce phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
Neuropharmacology 1988;27(7):771-5.
1988: Wouter Koek; James H Woods; Gail Winger
MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1988;245(3):969-74.
1987: Edward Domino; D Gole; Wouter Koek
Metaphit, a proposed phencyclidine receptor acylator: disruption of mouse motor behavior and absence of PCP antagonist activity.
The Journal of pharmacology and experimental therapeutics 1987;243(1):95-100.
1987: Wouter Koek; James H Woods; M V Mattson; A E Jacobson; P J Mudar
Excitatory amino acid antagonists induce a phencyclidine-like catalepsy in pigeons: structure-activity studies.
Neuropharmacology 1987;26(9):1261-5.
1987: Wouter Koek; James H Woods; A E Jacobson; K C Rice
Phencyclidine (PCP)-like discriminative stimulus effects of metaphit and of 2-amino-5-phosphonovalerate in pigeons: generality across different training doses of PCP.
Psychopharmacology 1987;93(4):437-42.
1987: Wouter Koek; James H Woods; Paul Ornstein
A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats.
Psychopharmacology 1987;91(3):297-304.
1986: Wouter Koek; James H Woods; Paul Ornstein
Phencyclidine-like behavioral effects in pigeons induced by systemic administration of the excitatory amino acid antagonist, 2-amino-5-phosphonovalerate.
Life sciences 1986;39(11):973-8.
1986: Wouter Koek; James H Woods; Arthur E Jacobson; Kenner C Rice; R A Lessor
Metaphit, a proposed phencyclidine receptor acylator: phencyclidine-like behavioral effects and evidence of absence of antagonist activity in pigeons and in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 1986;237(2):386-92.
1986: Wouter Koek; E Kleer; P J Mudar; James H Woods
Phencyclidine-like catalepsy induced by the excitatory amino acid antagonist DL-2-amino-5-phosphonovalerate.
Behavioural brain research 1986;19(3):257-9.
1986: Wouter Koek; James H Woods
Response repetition in pigeons: pharmacological and behavioral specificity.
Psychopharmacology 1986;90(4):475-81.
1985: Wouter Koek; R Head; Elzbieta Holsztynska; James H Woods; Edward Domino; Arthur E Jacobson; M F Rafferty; Kenner C Rice; R A Lessor
Effects of metaphit, a proposed phencyclidine receptor acylator, on catalepsy in pigeons.
The Journal of pharmacology and experimental therapeutics 1985;234(3):648-53.
1984: Wouter Koek; James H Woods; K C Rice; A E Jacobson; P N Huguenin; T R Burke
Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
European journal of pharmacology 1984;106(3):635-8.
1984: Wouter Koek; J L Slangen
Acute effects of naloxone and naltrexone, but lack of delayed effects, on exploratory behavior in the rat.
Psychopharmacology 1984;84(3):383-7.
1984: Wouter Koek; J L Slangen
Effects of d-amphetamine and morphine on delayed discrimination: signal detection analysis and assessment of response repetition in the performance deficits.
Psychopharmacology 1984;83(4):346-50.
1984: J De Vry; Wouter Koek; J L Slangen
Effects of drug-induced differences in reinforcement frequency on discriminative stimulus properties of fentanyl.
Psychopharmacology 1984;83(3):257-61.
1984: Wouter Koek; J L Slangen
External stimulus control in a "drug-discrimination" procedure: drug effects and inter-animal variation.
Psychopharmacology 1984;82(3):168-73.
1983: Wouter Koek; J L Slangen
Effects of d-amphetamine and morphine on discrimination: signal detection analysis and assessment of response repetition in the performance deficits.
Psychopharmacology 1983;80(2):125-8.
1982: Wouter Koek; J L Slangen
The role of fentanyl training dose and of the alternative stimulus condition in drug generalization.
Psychopharmacology 1982;76(2):149-56.
1981: Wouter Koek; J L Slangen
Habituation of the head-poke response: effects of an amphetamine-barbiturate mixture, PLG and fenfluramine.
Psychopharmacology 1981;72(3):251-6.