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Ralph DeFronzo

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TOP 3
Itamar Raz; Matthew C Riddle; Julio Rosenstock; John B Buse; Juliana C N Chan; Ralph DeFronzo; Stefano Del Prato; Ele Ferrannini; Philip D Home; Silvio E Inzucchi; Lawrence A Leiter; Derek LeRoith; William T Cefalu
Personalized management of hyperglycemia in type 2 diabetes: reflections from a diabetes care editors' expert forum.
Jingjing Zhang; Ning Zhang; Lijun Zhou; Zhiguang Zhou; John M Cunningham; Ralph DeFronzo; Wei Huang; Xiuling Li; Jing Liu; Meilian Liu; Xin Yun Lu; Nicolas Musi; Zhipeng Xu; Feng Liu
Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis.
Meilian Liu; Nicolas Musi; Philipp E Scherer; Lauren B Sloane; Christi A Walter; Sarah Ann Wilk; Guangda Xiang; Ruihua Xiang; Ning Zhang; Lijun Zhou; Reto Asmis; Steven Austad; Kian Azarnoush; Hongzhi Chen; Ralph DeFronzo; Lily Dong; Feng Liu
Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance.

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2013: Itamar Raz; Matthew C Riddle; Julio Rosenstock; John B Buse; Juliana C N Chan; Ralph DeFronzo; Stefano Del Prato; Ele Ferrannini; Philip D Home; Silvio E Inzucchi; Lawrence A Leiter; Derek LeRoith; William T Cefalu
Personalized management of hyperglycemia in type 2 diabetes: reflections from a diabetes care editors' expert forum.
Diabetes care 2013;36(6):1779-88.
2012: Jingjing Zhang; Ning Zhang; Lijun Zhou; Zhiguang Zhou; John M Cunningham; Ralph DeFronzo; Wei Huang; Xiuling Li; Jing Liu; Meilian Liu; Xin Yun Lu; Nicolas Musi; Zhipeng Xu; Feng Liu
Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis.
Diabetes 2012;61(12):3189-98.
2012: Meilian Liu; Nicolas Musi; Philipp E Scherer; Lauren B Sloane; Christi A Walter; Sarah Ann Wilk; Guangda Xiang; Ruihua Xiang; Ning Zhang; Lijun Zhou; Reto Asmis; Steven Austad; Kian Azarnoush; Hongzhi Chen; Ralph DeFronzo; Lily Dong; Feng Liu
Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance.
Diabetes 2012;61(11):2776-86.
2012: Jiwen Jim Liu; TaeWeon Lee; Ralph DeFronzo
Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans?
Diabetes 2012;61(9):2199-204.
2012: Jørgen Jensen; Marjorie Molina-Carrion; Kei Sakamoto; Jorid T Stuenæs; Puntip Tantiwong; Ralph DeFronzo; Nicolas Musi
Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects.
American journal of physiology. Endocrinology and metabolism 2012;303(1):E82-9.
2012: Muhammad Abdul-Ghani; Luke Norton; Ralph DeFronzo
Efficacy and safety of SGLT2 inhibitors in the treatment of type 2 diabetes mellitus.
Current diabetes reports 2012;12(3):230-8.
2012: Ralph DeFronzo; P Fleck; Qais A Mekki; Charles F Burant; C Wilson; R E Pratley
Efficacy and tolerability of the DPP-4 inhibitor alogliptin combined with pioglitazone, in metformin-treated patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2012;97(5):1615-22.
2012: John Armato; Ralph DeFronzo; Muhammad Abdul-Ghani; Ron Ruby
Successful treatment of prediabetes in clinical practice: targeting insulin resistance and β-cell dysfunction.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2012;18(3):342-50.
2012: B Doiron; W Hu; L Norton; Ralph DeFronzo
Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels.
Diabetologia 2012;55(3):719-28.
2012: Andrea Tura; Giovanni Pacini; Ralph DeFronzo; Ele Ferrannini; Amalia Gastaldelli; Alexandra Kautzky-Willer; Andrea Mari
Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models.
Metabolism: clinical and experimental 2012;61(3):434-43.
2012: Mustafa Kanat; Andrea Mari; Luke Norton; Diedre Winnier; Ralph DeFronzo; Chris Jenkinson; Muhammad Abdul-Ghani
Distinct β-cell defects in impaired fasting glucose and impaired glucose tolerance.
Diabetes 2012;61(2):447-53.
2012: Ralph DeFronzo; J A Davidson; S Del Prato
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia.
Diabetes, obesity & metabolism 2012;14(1):5-14.
2011: L Norton; D Winnier; Muhammad Abdul-Ghani; M Fourcaudot; Christopher Jenkinson; F F Mehta; Ralph DeFronzo
Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.
Diabetologia 2011;54(12):3132-42.
2011: Sathyaseelan S Deepa; Ralph DeFronzo; Cai Li; Feng Liu; Xuming Mao; Nicolas Musi; Jiyoon Ryu; Changhua Wang; Ning Zhang; Lijun Zhou; Lily Dong
APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.
Molecular endocrinology (Baltimore, Md.) 2011;25(10):1773-85.
2011: M Fernandez; Ele Ferrannini; Amalia Gastaldelli; Jean Hardies; Nicolas Musi; R Petz; Puntip Tantiwong; Curtis Triplitt; A Casolaro; Eugenio Cersosimo; Ralph DeFronzo
Metabolic effects of muraglitazar in type 2 diabetic subjects.
Diabetes, obesity & metabolism 2011;13(10):893-902.
2011: Muhammad Abdul-Ghani; Tamam Abdul-Ghani; Insoma Bo; Ralph DeFronzo; Jasmina Karavic; Michael P Stern; Tiinamaija Tuomi; Leif Groop
Two-step approach for the prediction of future type 2 diabetes risk.
Diabetes care 2011;34(9):2108-12.
2011: Mustafa Kanat; Luke Norton; Diedre Winnier; Ralph DeFronzo; Chris Jenkinson; Muhammad Abdul-Ghani
Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose.
Acta diabetologica 2011;48(3):209-17.
2011: Ralph DeFronzo; Muhammad Abdul-Ghani
Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose.
The American journal of cardiology 2011;108(3 Suppl):3B-24B.
2011: Ralph DeFronzo; Muhammad Abdul-Ghani
Preservation of β-cell function: the key to diabetes prevention.
The Journal of clinical endocrinology and metabolism 2011;96(8):2354-66.
2011: Sangeeta Ghosh; Joaquin Joya-Galeana; Natalie Lefort; Raweewan Lertwattanarak; Lawrence J. Manderino; Marjorie Molina-Carrion; Muhammad Abdul-Ghani; Benjamin P Bowen; Ralph DeFronzo; Jose de Jesus Garduno-Garcia; Arlan G Richardson; Holly Van Remmen; Nicolas Musi
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.
Diabetes 2011;60(8):2051-60.
2011: Muhammad Abdul-Ghani; Tamam Abdul-Ghani; Antje Bergmann; Stefan Bornstein; Ralph DeFronzo; Sabine Fischer; Gabriele Müller; Peter Schwarz
Role of glycated hemoglobin in the prediction of future risk of T2DM.
The Journal of clinical endocrinology and metabolism 2011;96(8):2596-600.
2011: Muhammad Abdul-Ghani; Luke Norton; Ralph DeFronzo
Role of sodium-glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes.
Endocrine reviews 2011;32(4):515-31.
2011: Ele Ferrannini; R Spanheimer; R G Wilcox; D J Betteridge; B Charbonnel; Ralph DeFronzo; J A Dormandy; E Erdmann; M Laakso
High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive.
Diabetes, obesity & metabolism 2011;13(8):759-64.
2011: Eugenio Cersosimo; Amalia Gastaldelli; A Cervera; Estela Wajcberg; A Sriwijilkamol; M Fernandez; P Zuo; R Petz; Curtis Triplitt; Nicolas Musi; Ralph DeFronzo
Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism 2011;96(6):1763-70.
2011: Ralph DeFronzo; Muhammad Abdul-Ghani
Type 2 diabetes can be prevented with early pharmacological intervention.
Diabetes care 2011;34 Suppl 2():S202-9.
2011: J Joya-Galeana; M Fernandez; A Cervera; Sara M Reyna; S Ghosh; C Triplitt; Nicolas Musi; Ralph DeFronzo; Eugenio Cersosimo
Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects.
Diabetes/metabolism research and reviews 2011;27(4):373-82.
2011: Ralph DeFronzo
Bromocriptine: a sympatholytic, d2-dopamine agonist for the treatment of type 2 diabetes.
Diabetes care 2011;34(4):789-94.
2011: Mustafa Kanat; Diedre Winnier; Luke Norton; Nazik Arar; Chris Jenkinson; Ralph DeFronzo; Muhammad Abdul-Ghani
The relationship between {beta}-cell function and glycated hemoglobin: results from the veterans administration genetic epidemiology study.
Diabetes care 2011;34(4):1006-10.
2011: Ralph DeFronzo; Devjit Tripathy; Dawn C Schwenke; MaryAnn Banerji; George A Bray; Thomas A Buchanan; Stephen C Clement; Robert R Henry; Howard N Hodis; Abbas E Kitabchi; Wendy J Mack; Sunder Mudaliar; Robert E Ratner; Ken Williams; Frankie B Stentz; Nicolas Musi; Peter D Reaven
Pioglitazone for diabetes prevention in impaired glucose tolerance.
The New England journal of medicine 2011;364(12):1104-15.
2011: Christian Anderwald; Amalia Gastaldelli; Andrea Tura; Michael Krebs; Miriam Promintzer-Schifferl; Alexandra Kautzky-Willer; Marietta Stadler; Ralph DeFronzo; Giovanni Pacini; Martin G Bischof
Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males.
The Journal of clinical endocrinology and metabolism 2011;96(2):515-24.
2011: Alex F Bokov; Ralph DeFronzo; Rebecca C Erickson; Neha Garg; Jonathan Gelfond; Gene B Hubbard; Yuji Ikeno; Nicolas Musi; Sachin Thakur; Ning Zhang; Martin Adamo; Arlan G Richardson
Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?
PloS one 2011;6(11):e26891.
2011: Subhash Kamath; Vicki Mattern; Ana Maria Paez; Andrea Ricotti; IRAM PABLO RODRIGUEZ-SANCHEZ; M Elizabeth Tejero; Devjit Tripathy; Amalia Gastaldelli; Rodolfo Guardado-Mendoza; Glenn A Halff; Paul B Higgins; Lilia M Jimenez-Ceja; Gregory Abrahamian; Raul A Bastarrachea; Francesca Casiraghi; Alberto O Chavez; Gary W Cline; Anthony G Comuzzie; Alberto M Davalli; Ralph DeFronzo; Edward J Dick; Franco Folli
Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates.
PloS one 2011;6(11):e27617.
2011: Giovanna Muscogiuri; Amrita Kamat; Bogdan Balas; Andrea Giaccari; Ralph DeFronzo; Nicolas Musi; Michael S Katz
β-Adrenergic Responsive Induction of Insulin Resistance in Liver of Aging Rats.
Endocrine research 2011;36(2):74-82.
2011: Sobha Puppala; Dawn K Coletta; Jennifer Schneider; Shirley L Hu; Vidya S Farook; Thomas D Dyer; Rector Arya; John C Blangero; Ravindranath Duggirala; Ralph DeFronzo; Christopher Jenkinson
Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and confirmation of a major susceptibility locus on chromosome 6q14.1.
Human heredity 2011;71(1):1-10.
2010: Puntip Tantiwong; Karthigayan Shanmugasundaram; Adriana Monroy; Sangeeta Ghosh; Mengyao Li; Ralph DeFronzo; Eugenio Cersosimo; Apiradee Sriwijitkamol; Sumathy Mohan; Nicolas Musi
NF-κB activity in muscle from obese and type 2 diabetic subjects under basal and exercise-stimulated conditions.
American journal of physiology. Endocrinology and metabolism 2010;299(5):E794-801.
2010: Sangeeta R Kashyap; Linda Roman; Lawrence J. Manderino; Ralph DeFronzo; Mandeep Bajaj
Hypoadiponectinemia is closely associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
Metabolic syndrome and related disorders 2010;8(5):459-63.
2010: Leonard C Glass; Kenneth Cusi; Rachele Berria; Roberta Petz; Eugenio Cersosimo; Ralph DeFronzo; Amalia Gastaldelli
Pioglitazone improvement of fasting and postprandial hyperglycaemia in Mexican-American patients with Type 2 diabetes: a double tracer OGTT study.
Clinical endocrinology 2010;73(3):339-45.
2010: Ralph DeFronzo; Masafumi Matsuda
Reduced time points to calculate the composite index.
Diabetes care 2010;33(7):e93.
2010: Ralph DeFronzo
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
Diabetologia 2010;53(7):1270-87.
2010: Guntram Schernthaner; A H Barnett; D J Betteridge; R Carmena; A Ceriello; B Charbonnel; M Hanefeld; R Lehmann; M T Malecki; R Nesto; V Pirags; A Scheen; J Seufert; A Sjohölm; A Tsatsoulis; Ralph DeFronzo
Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Diabetologia 2010;53(7):1258-69.
2010: Muhammad Abdul-Ghani; Valeriya Lyssenko; Tiinamaija Tuomi; Ralph DeFronzo; Leif Groop
The shape of plasma glucose concentration curve during OGTT predicts future risk of type 2 diabetes.
Diabetes/metabolism research and reviews 2010;26(4):280-6.
2010: Paolo Pozzilli; R David Leslie; Juliana Chan; Ralph DeFronzo; Louis Monnier; Itamar Raz; Stefano Del Prato
The A1C and ABCD of glycaemia management in type 2 diabetes: a physician's personalized approach.
Diabetes/metabolism research and reviews 2010;26(4):239-44.
2010: Bernard Charbonnel; Ralph DeFronzo; Jaime Davidson; Ole Schmitz; Kare Birkeland; Valdis Pirags; André Scheen
Pioglitazone use in combination with insulin in the prospective pioglitazone clinical trial in macrovascular events study (PROactive19).
The Journal of clinical endocrinology and metabolism 2010;95(5):2163-71.
2010: Cynthia Blanco; Hanyu Liang; Joaquin Joya-Galeana; Ralph DeFronzo; Donald McCurnin; Nicolas Musi
The ontogeny of insulin signaling in the preterm baboon model.
Endocrinology 2010;151(5):1990-7.
2010: Ralph DeFronzo; Curtis Triplitt; Yongming Qu; Michelle S Lewis; David Maggs; Leonard C Glass
Effects of exenatide plus rosiglitazone on beta-cell function and insulin sensitivity in subjects with type 2 diabetes on metformin.
Diabetes care 2010;33(5):951-7.
2010: Mandeep Bajaj; Rais Baig; Swangjit Suraamornkul; L Jean Hardies; Dawn K Coletta; Gary W Cline; Adriana Monroy; Shailja Koul; Apiradee Sriwijitkamol; Nicolas Musi; Gerald I Shulman; Ralph DeFronzo
Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2010;95(4):1916-23.
2010: Ralph DeFronzo; A H Stonehouse; J Han; Matthew Wintle
Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials.
Diabetic medicine : a journal of the British Diabetic Association 2010;27(3):309-17.
2010: Ralph DeFronzo
Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going.
The American journal of medicine 2010;123(3 Suppl):S38-48.
2010: Ralph DeFronzo
Current issues in the treatment of type 2 diabetes. Introduction.
The American journal of medicine 2010;123(3 Suppl):S1-2.
2010: Ralph DeFronzo; M A Banerji; G A Bray; Thomas A Buchanan; S Clement; R R Henry; A E Kitabchi; S Mudaliar; Nicolas Musi; R Ratner; P Reaven; D C Schwenke; F D Stentz; Devjit Tripathy
Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study.
Diabetologia 2010;53(3):435-45.
2010: Muhammad Abdul-Ghani; Michael P Stern; Valeriya Lyssenko; Tiinamaija Tuomi; Leif Groop; Ralph DeFronzo
Minimal contribution of fasting hyperglycemia to the incidence of type 2 diabetes in subjects with normal 2-h plasma glucose.
Diabetes care 2010;33(3):557-61.
2010: Curtis Triplitt; Eugenio Cersosimo; Ralph DeFronzo
Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment.
Vascular health and risk management 2010;6():671-90.
2010: Muhammad Abdul-Ghani; Ralph DeFronzo
Pathogenesis of insulin resistance in skeletal muscle.
Journal of biomedicine & biotechnology 2010;2010():476279.
2010: K G Parhofer; K I Birkeland; Ralph DeFronzo; Stefano Del Prato; A Bhaumik; A Ptaszynska
Irbesartan has no short-term effect on insulin resistance in hypertensive patients with additional cardiometabolic risk factors (i-RESPOND).
International journal of clinical practice 2010;64(2):160-8.
2010: Alberto O Chavez; Subhash Kamath; Rucha Jani; Lokendra K Sharma; Adriana Monroy; Muhammad Abdul-Ghani; Victoria E Centonze; Padma Sathyanarayana; Dawn K Coletta; Christopher Jenkinson; Yidong Bai; Franco Folli; Ralph DeFronzo; Devjit Tripathy
Effect of short-term free Fatty acids elevation on mitochondrial function in skeletal muscle of healthy individuals.
The Journal of clinical endocrinology and metabolism 2010;95(1):422-9.
2009: Muhammad Abdul-Ghani; Ralph DeFronzo
Plasma glucose concentration and prediction of future risk of type 2 diabetes.
Diabetes care 2009;32 Suppl 2():S194-8.
2009: Ralph DeFronzo; Devjit Tripathy
Skeletal muscle insulin resistance is the primary defect in type 2 diabetes.
Diabetes care 2009;32 Suppl 2():S157-63.
2009: A Monroy; S Kamath; A O Chavez; Victoria Frohlich; M Veerasamy; A Barrentine; J J Wewer; Dawn K Coletta; Christopher Jenkinson; R M Jhingan; D Smokler; Sara M Reyna; Nicolas Musi; R Khokka; M Federici; Devjit Tripathy; Ralph DeFronzo; Franco Folli
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Diabetologia 2009;52(10):2169-81.
2009: Ralph DeFronzo; Miguel N Hissa; Alan J Garber; Jorge Luiz Gross; Raina Yuyan Duan; Shoba Ravichandran; Roland S Chen
The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone.
Diabetes care 2009;32(9):1649-55.
2009: Rodolfo Guardado-Mendoza; Alberto M Davalli; Alberto O Chavez; Gene B Hubbard; Edward J Dick; Abraham Majluf-Cruz; Carlos E Tene-Perez; Lukasz Goldschmidt; John Hart; Carla Perego; Anthony G Comuzzie; Maria Elizabeth Tejero; Giovanna Finzi; Claudia Placidi; Stefano La Rosa; Carlo Capella; Glenn A Halff; Amalia Gastaldelli; Ralph DeFronzo; Franco Folli
Pancreatic islet amyloidosis, beta-cell apoptosis, and alpha-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13992-7.
2009: Alberto O Chavez; Marjorie Molina-Carrion; Muhammad Abdul-Ghani; Franco Folli; Ralph DeFronzo; Devjit Tripathy
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.
Diabetes care 2009;32(8):1542-6.
2009: Ralph DeFronzo; Muhammad Abdul-Ghani
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al.
Diabetes care 2009;32(7):e86; author reply e87.
2009: Muhammad Abdul-Ghani; Ralph DeFronzo
Pathophysiology of prediabetes.
Current diabetes reports 2009;9(3):193-9.
2009: Ralph DeFronzo
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
Diabetes 2009;58(4):773-95.
2009: Huiyun Liang; Bogdan Balas; Puntip Tantiwong; John Dube; Bret H Goodpaster; Robert M O'Doherty; Ralph DeFronzo; Arlan G Richardson; Nicolas Musi; Walter F Ward
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E945-54.
2009: Alberto O Chavez; Dawn K Coletta; Subhash Kamath; Douglas T Cromack; Adriana Monroy; Franco Folli; Ralph DeFronzo; Devjit Tripathy
Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E758-64.
2009: Muhammad Abdul-Ghani; R Jani; A Chavez; M Molina-Carrion; Devjit Tripathy; Ralph DeFronzo
Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.
Diabetologia 2009;52(4):574-82.
2009: D K Coletta; A Sriwijitkamol; E Wajcberg; P Tantiwong; M Li; M Prentki; M Madiraju; Christopher Jenkinson; Eugenio Cersosimo; Nicolas Musi; Ralph DeFronzo
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
Diabetologia 2009;52(4):723-32.
2009: Muhammad Abdul-Ghani; Valeriya Lyssenko; Tiinamaija Tuomi; Ralph DeFronzo; Leif Groop
Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study.
Diabetes care 2009;32(2):281-6.
2009: Jacob Haus; Sangeeta R Kashyap; Takhar Kasumov; Renliang Zhang; Karen R Kelly; Ralph DeFronzo; John P Kirwan
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.
Diabetes 2009;58(2):337-43.
2009: Yoshinori Miyazaki; Ralph DeFronzo
Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type.
Cardiovascular diabetology 2009;8():44.
2009: Ralph DeFronzo; Maryann Banerji; George A Bray; Thomas A Buchanan; Stephen Clement; Robert R Henry; Abbas E Kitabchi; Sunder Mudaliar; Nicolas Musi; Robert Ratner; Peter D Reaven; Dawn Schwenke; Frankie B Stentz; Devjit Tripathy
Actos Now for the prevention of diabetes (ACT NOW) study.
BMC endocrine disorders 2009;9():17.
2009: Alberto O Chavez; Amalia Gastaldelli; Rodolfo Guardado-Mendoza; Juan C Lopez-Alvarenga; M Michelle Leland; M Elizabeth Tejero; GianPio Sorice; Francesca Casiraghi; Alberto Davalli; Raul A Bastarrachea; Anthony G Comuzzie; Ralph DeFronzo; Franco Folli
Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons.
Cardiovascular diabetology 2009;8():22.
2009: Dawn K Coletta; Jennifer Schneider; Shirley L Hu; Thomas D Dyer; Sobha Puppala; Vidya S Farook; Rector Arya; Donna Lehman; John C Blangero; Ralph DeFronzo; Ravindranath Duggirala; Christopher Jenkinson
Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study.
Diabetes 2009;58(1):279-84.
2009: Amalia Gastaldelli; Lucia Perego; Michele Paganelli; Giorgio Sesti; Marta Hribal; Alberto O Chavez; Ralph DeFronzo; Antonio Pontiroli; Franco Folli
Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: effect of weight loss after gastric banding.
Obesity surgery 2009;19(1):80-6.
2008: Ralph DeFronzo; Penny R Fleck; Craig A Wilson; Qais Mekki
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.
Diabetes care 2008;31(12):2315-7.
2008: Yoshinori Miyazaki; Ralph DeFronzo
Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients.
Diabetes, obesity & metabolism 2008;10(12):1204-11.
2008: Muhammad Abdul-Ghani; Masafumi Matsuda; Ralph DeFronzo
Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(11):1289-94.
2008: Julio Rosenstock; Richard Bergenstal; Ralph DeFronzo; Irl B Hirsch; David Klonoff; Anders H Boss; David Kramer; Richard Petrucci; Wen Yu; Brian Levy
Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents.
Diabetes care 2008;31(11):2177-82.
2008: Ralph DeFronzo; Ted Okerson; prabhakar viswanathan; Xuesong Guan; John H Holcombe; Leigh MacConell
Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study.
Current medical research and opinion 2008;24(10):2943-52.
2008: Sara M Reyna; Sangeeta Ghosh; Puntip Tantiwong; C S Reddy Meka; Phyllis A Eagan; Christopher Jenkinson; Eugenio Cersosimo; Ralph DeFronzo; Dawn K Coletta; Apiradee Sriwijitkamol; Nicolas Musi
Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.
Diabetes 2008;57(10):2595-602.
2008: Muhammad Abdul-Ghani; Ralph DeFronzo
Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2008;14(6):782-90.
2008: Muhammad Abdul-Ghani; Florian Muller; Yuhong Liu; Alberto O Chavez; Bogdan Balas; Pengou Zuo; Zhi Chang; Devjit Tripathy; Rucha Jani; Marjorie Molina-Carrion; Adriana Monroy; Franco Folli; Holly Van Remmen; Ralph DeFronzo
Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E678-85.
2008: Muhammad Abdul-Ghani; Marjorie Molina-Carrion; Rucha Jani; Christopher Jenkinson; Ralph DeFronzo
Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin.
Acta diabetologica 2008;45(3):147-50.
2008: Positano Vincenzo; Kenneth Cusi; Maria Filomena Santarelli; Anna Maria Sironi; Roberta Petz; Ralph DeFronzo; Luigi Landini; Amalia Gastaldelli
Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.
Journal of magnetic resonance imaging : JMRI 2008;28(2):403-10.
2008: Muhammad Abdul-Ghani; Masafumi Matsuda; Rucha Jani; Christopher Jenkinson; Dawn K Coletta; Kohei Kaku; Ralph DeFronzo
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance.
American journal of physiology. Endocrinology and metabolism 2008;295(2):E401-6.
2008: Muhammad Abdul-Ghani; Tamam Abdul-Ghani; Nibal Ali; Ralph DeFronzo
One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes.
Diabetes care 2008;31(8):1650-5.
2008: Yoshinori Miyazaki; Hiroshi Akasaka; Hirofumi Ohnishi; Shigeyuki Saitoh; Ralph DeFronzo; Kazuaki Shimamoto
Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(7):1357-63.
2008: Christopher Jenkinson; Dawn K Coletta; Marion Flechtner-Mors; Shirley L Hu; Marcel J Fourcaudot; Lenore M Rodriguez; Jennifer Schneider; Rector Arya; Michael P Stern; John C Blangero; Ravindranath Duggirala; Ralph DeFronzo
Association of genetic variation in ENPP1 with obesity-related phenotypes.
Obesity (Silver Spring, Md.) 2008;16(7):1708-13.
2008: Muhammad Abdul-Ghani; Ralph DeFronzo
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus.
Current diabetes reports 2008;8(3):173-8.
2008: Antonio Cervera; Estela Wajcberg; Apiradee Sriwijitkamol; Marianella Fernandez; Pengou Zuo; Curtis Triplitt; Nicolas Musi; Ralph DeFronzo; Eugenio Cersosimo
Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E846-52.
2008: Dawn K Coletta; Bogdan Balas; Alberto O Chavez; Muhammad Baig; Muhammad Abdul-Ghani; Sangeeta Kashyap; Franco Folli; Devjit Tripathy; Lawrence J. Manderino; John Cornell; Ralph DeFronzo; Christopher Jenkinson
Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E910-7.
2008: D John Betteridge; Ralph DeFronzo; Robert J Chilton
PROactive: time for a critical appraisal.
European heart journal 2008;29(8):969-83.
2008: Alberto O Chavez; Juan C Lopez-Alvarenga; M Elizabeth Tejero; Curtis Triplitt; Raul A Bastarrachea; Apiradee Sriwijitkamol; Puntip Tantiwong; Venkata Saroja Voruganti; Nicolas Musi; Anthony G Comuzzie; Ralph DeFronzo; Franco Folli
Physiological and molecular determinants of insulin action in the baboon.
Diabetes 2008;57(4):899-908.
2008: Rucha Jani; Marjorie Molina; Masafumi Matsuda; Bogdan Balas; Alberto Chavez; Ralph DeFronzo; Muhammad Abdul-Ghani
Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range.
Diabetes care 2008;31(2):311-5.
2008: Karl Thomaseth; Alessandra Pavan; Rachele Berria; Leonard Glass; Ralph DeFronzo; Amalia Gastaldelli
Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test.
Computer methods and programs in biomedicine 2008;89(2):132-40.
2008: Christian A Schneider; Ele Ferrannini; Ralph DeFronzo; Guntram Schernthaner; John Yates; Erland Erdmann
Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney disease.
Journal of the American Society of Nephrology : JASN 2008;19(1):182-7.
2008: Sangeeta R Kashyap; Abigail Lara; Renliang Zhang; Young Mi Park; Ralph DeFronzo
Insulin reduces plasma arginase activity in type 2 diabetic patients.
Diabetes care 2008;31(1):134-9.
2008: Marianella Fernandez; Curtis Triplitt; Estela Wajcberg; Apiradee A Sriwijilkamol; Nicolas Musi; Kenneth Cusi; Ralph DeFronzo; Eugenio Cersosimo
Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms.
Diabetes care 2008;31(1):121-7.
2007: Y Miyazaki; Eugenio Cersosimo; Curtis Triplitt; Ralph DeFronzo
Rosiglitazone decreases albuminuria in type 2 diabetic patients.
Kidney international 2007;72(11):1367-73.
2007: Lixin Wang; Bogdan Balas; Christine Y Christ-Roberts; Ryang Yeo Kim; Fresnida J Ramos; Chintan K Kikani; Cuiling Li; Chuxia Deng; Sara M Reyna; Nicolas Musi; Lily Dong; Ralph DeFronzo; Feng Liu
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Molecular and cellular biology 2007;27(18):6497-505.
2007: Rachele Berria; L Glass; Archana Mahankali; Yoshinori Miyazaki; A Monroy; Elena A De Filippis; Kenneth Cusi; Eugenio Cersosimo; Ralph DeFronzo; Amalia Gastaldelli
Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.
Clinical pharmacology and therapeutics 2007;82(3):275-81.
2007: Amalia Gastaldelli; Kenneth Cusi; Maura Pettiti; Jean Hardies; Yoshinori Miyazaki; Rachele Berria; Emma Buzzigoli; Anna Maria Sironi; Eugenio Cersosimo; Ele Ferrannini; Ralph DeFronzo
Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.
Gastroenterology 2007;133(2):496-506.
2007: Mandeep Bajaj; Swangjit Suraamornkul; L Jean Hardies; Leonard Glass; Nicolas Musi; Ralph DeFronzo
Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus.
Diabetologia 2007;50(8):1723-31.
2007: Muhammad Abdul-Ghani; Ken Williams; Ralph DeFronzo; Michael P Stern
What is the best predictor of future type 2 diabetes?
Diabetes care 2007;30(6):1544-8.
2007: Muhammad Abdul-Ghani; Ralph DeFronzo
Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion.
The Journal of clinical endocrinology and metabolism 2007;92(5):1778-84.
2007: Dawn K Coletta; Jennifer Schneider; Michael P Stern; John C Blangero; Ralph DeFronzo; Ravindranath Duggirala; Christopher Jenkinson
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.
Obesity (Silver Spring, Md.) 2007;15(4):809-15.
2007: Bogdan Balas; Muhammad R Baig; Catherine Watson; Beth E Dunning; Monica Ligueros-Saylan; Yibin Wang; Yan-Ling He; Celia Darland; Jens J Holst; Carolyn F Deacon; Kenneth Cusi; Andrea Mari; James Foley; Ralph DeFronzo
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2007;92(4):1249-55.
2007: Estela Wajcberg; Apiradee Sriwijitkamol; Nicolas Musi; Ralph DeFronzo; Eugenio Cersosimo
Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone.
The Journal of clinical endocrinology and metabolism 2007;92(4):1256-62.
2007: Sangeeta R Kashyap; Ralph DeFronzo
The insulin resistance syndrome: physiological considerations.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(1):13-9.
2007: Apiradee Sriwijitkamol; Dawn K Coletta; Estela Wajcberg; Gabriela B Balbontin; Sara M Reyna; John Barrientes; Phyllis A Eagan; Christopher Jenkinson; Eugenio Cersosimo; Ralph DeFronzo; Kei Sakamoto; Nicolas Musi
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study.
Diabetes 2007;56(3):836-48.
2007: Mandeep Bajaj; Rafael Medina-Navarro; Swangjit Suraamornkul; Christian Meyer; Ralph DeFronzo; Lawrence J. Manderino
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.
Diabetes 2007;56(3):743-52.
2007: David M Nathan; Mayer B Davidson; Ralph DeFronzo; Robert J Heine; Robert R Henry; Richard E Pratley; Bernard Zinman
Impaired fasting glucose and impaired glucose tolerance: implications for care.
Diabetes care 2007;30(3):753-9.
2007: Amalia Gastaldelli; Ele Ferrannini; Yoshinori Miyazaki; Masafumi Matsuda; Andrea Mari; Ralph DeFronzo
Thiazolidinediones improve beta-cell function in type 2 diabetic patients.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E871-83.
2007: William R Hendee; Filip Banovac; Paul Langford Carson; Ralph DeFronzo; William Eckelman; Gary D Fullerton; Steven M Larson; Gordon McLennan; Michael J Welch
Biomedical imaging research opportunities workshop IV: a white paper.
Medical physics 2007;34(2):673-9.
2007: Muhammad Abdul-Ghani; Masafumi Matsuda; Bogdan Balas; Ralph DeFronzo
Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test.
Diabetes care 2007;30(1):89-94.
2007: Rucha Jani; Curtis Triplitt; Charles Reasner; Ralph DeFronzo
First approved inhaled insulin therapy for diabetes mellitus.
Expert opinion on drug delivery 2007;4(1):63-76.
2007: Merri L Pendergrass; Alessandra Bertoldo; Riccardo Bonadonna; Gianluca Nucci; Lawrence J. Manderino; Claudio Cobelli; Ralph DeFronzo
Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E92-100.
2006: Estela Wajcberg; Nimmi Thoppil; Shreya Patel; Marianella Fernandez; Daniel Hale; Ralph DeFronzo; Eugenio Cersosimo
Comprehensive assessment of postischemic vascular reactivity in Hispanic children and adults with and without diabetes mellitus.
Pediatric diabetes 2006;7(6):329-35.
2006: A Mari; Loretta L Nielsen; Nuwan Nanayakkara; Ralph DeFronzo; E Ferrannini; Amy E Halseth
Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(12):838-44.
2006: Renata Belfort; Stephen A Harrison; Kenneth Brown; Celia Darland; Joan Finch; Jean Hardies; Bogdan Balas; Amalia Gastaldelli; Fermin Tio; Joseph P Pulcini; Rachele Berria; Jennie Z Ma; Sunil Dwivedi; Russell Havranek; Chris Fincke; Ralph DeFronzo; George A Bannayan; Steven Schenker; Kenneth Cusi
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.
The New England journal of medicine 2006;355(22):2297-307.
2006: Curtis Triplitt; Leonard Glass; Yoshiniro Miyazaki; Estela Wajcberg; Amalia Gastaldelli; Elena A De Filippis; Eugenio Cersosimo; Ralph DeFronzo
Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.
Diabetes care 2006;29(11):2371-7.
2006: Greg Schimmack; Ralph DeFronzo; Nicolas Musi
AMP-activated protein kinase: Role in metabolism and therapeutic implications.
Diabetes, obesity & metabolism 2006;8(6):591-602.
2006: Eugenio Cersosimo; Ralph DeFronzo
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases.
Diabetes/metabolism research and reviews 2006;22(6):423-36.
2006: Amalia Gastaldelli; Yoshinori Miyazaki; Archana Mahankali; Rachele Berria; Maura Pettiti; Emma Buzzigoli; Ele Ferrannini; Ralph DeFronzo
The effect of pioglitazone on the liver: role of adiponectin.
Diabetes care 2006;29(10):2275-81.
2006: Dawn K Richardson; Jennifer Schneider; M J Fourcaudot; L M Rodriguez; Rector Arya; Thomas D Dyer; Laura A Almasy; John C Blangero; Michael P Stern; Ralph DeFronzo; Ravindranath Duggirala; Christopher Jenkinson
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Diabetologia 2006;49(10):2317-28.
2006: Rachele Berria; Amalia Gastaldelli; Scott Lucidi; Renata Belfort; Elena A De Filippis; Caraan Easton; Robert Brytzki; Kenneth Cusi; Lois Jovanovic; Ralph DeFronzo
Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.
Clinical pharmacology and therapeutics 2006;80(2):105-14.
2006: Ralph DeFronzo
Is insulin resistance atherogenic? Possible mechanisms.
Atherosclerosis. Supplements 2006;7(4):11-5.
2006: Anthony E Civitarese; Barbara Ukropcova; Stacy Carling; Matthew W Hulver; Ralph DeFronzo; Lawrence J. Manderino; Eric Ravussin; Steven R Smith
Role of adiponectin in human skeletal muscle bioenergetics.
Cell metabolism 2006;4(1):75-87.
2006: Muhammad Abdul-Ghani; Ken Williams; Ralph DeFronzo; Michael P Stern
Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose.
Diabetes care 2006;29(7):1613-8.
2006: Rector Arya; Ellen W Demerath; Christopher Jenkinson; Harald HH Goring; Sobha Puppala; Vidya S Farook; Sharon Fowler; Jennifer Schneider; Richard Granato; Roy G Resendez; Thomas D Dyer; Shelley A Cole; Laura A Almasy; Anthony G Comuzzie; Roger M Siervogel; Benjamin Bradshaw; Ralph DeFronzo; Jean W MacCluer; Michael P Stern; Bradford Towne; John C Blangero; Ravindranath Duggirala
A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies.
Human molecular genetics 2006;15(10):1569-79.
2006: Muhammad Abdul-Ghani; Christopher Jenkinson; Dawn K Richardson; Devjit Tripathy; Ralph DeFronzo
Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study.
Diabetes 2006;55(5):1430-5.
2006: Muhammad Abdul-Ghani; Devjit Tripathy; Ralph DeFronzo
Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.
Diabetes care 2006;29(5):1130-9.
2006: David M Kendall; Cindy J Rubin; Pharis Mohideen; Jean-Marie Ledeine; Rene Belder; Jorge Gross; Paul Norwood; Michael O'Mahony; Kenneth Sall; Greg Sloan; Anthony Roberts; Fred T Fiedorek; Ralph DeFronzo
Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.
Diabetes care 2006;29(5):1016-23.
2006: Apiradee Sriwijitkamol; John L Ivy; Christine Y Christ-Roberts; Ralph DeFronzo; Lawrence J. Manderino; Nicolas Musi
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E925-32.
2006: Apiradee Sriwijitkamol; Christine Y Christ-Roberts; Rachele Berria; Phyllis A Eagan; Thongchai Pratipanawatr; Ralph DeFronzo; Lawrence J. Manderino; Nicolas Musi
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.
Diabetes 2006;55(3):760-7.
2006: Amalia Gastaldelli; Yoshinori Miyazaki; Maura Pettiti; Eleonora Santini; Demetrio Ciociaro; Ralph DeFronzo; Ele Ferrannini
The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(3):806-12.
2005: Mandeep Bajaj; Swangjit Suraamornkul; Anthony Romanelli; Gary W Cline; Lawrence J. Manderino; Gerald I Shulman; Ralph DeFronzo
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 2005;54(11):3148-53.
2005: Muhammad Abdul-Ghani; Ralph DeFronzo
To: Godsland IF, Jeffs JA, Johnston DG (2004) loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166.
Diabetologia 2005;48(10):2187-8; author reply 2189-90.
2005: Ralph DeFronzo; Richard M Bergenstal; William T Cefalu; John Pullman; Sam Lerman; Bruce W Bode; Lawrence S Phillips
Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial.
Diabetes care 2005;28(8):1922-8.
2005: Renata Belfort; Lawrence J. Manderino; Sangeeta Kashyap; Kelly Wirfel; Thongchai Pratipanawatr; Rachele Berria; Ralph DeFronzo; Kenneth Cusi
Dose-response effect of elevated plasma free fatty acid on insulin signaling.
Diabetes 2005;54(6):1640-8.
2005: Ralph DeFronzo; Robert E Ratner; Jenny Han; Dennis D Kim; Mark S Fineman; Alain D Baron
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.
Diabetes care 2005;28(5):1092-100.
2005: Dawn K Richardson; Sangeeta Kashyap; Mandeep Bajaj; Kenneth Cusi; Steven J Mandarino; Jean Finlayson; Ralph DeFronzo; Christopher Jenkinson; Lawrence J. Manderino
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
The Journal of biological chemistry 2005;280(11):10290-7.
2005: Steven E Stern; Ken Williams; Ele Ferrannini; Ralph DeFronzo; Clifton Bogardus; Michael P Stern
Identification of individuals with insulin resistance using routine clinical measurements.
Diabetes 2005;54(2):333-9.
2005: Sangeeta Kashyap; Linda Roman; Jennifer Lamont; Bettie Sue Masters; Mandeep Bajaj; Swangjit Suraamornkul; Renata Belfort; Rachele Berria; Dean Kellogg; Yanjuan Liu; Ralph DeFronzo
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism 2005;90(2):1100-5.
2005: Phillippa J Miranda; Ralph DeFronzo; Robert M Califf; John R Guyton
Metabolic syndrome: definition, pathophysiology, and mechanisms.
American heart journal 2005;149(1):33-45.
2005: Phillippa J Miranda; Ralph DeFronzo; Robert M Califf; John R Guyton
Metabolic syndrome: evaluation of pathological and therapeutic outcomes.
American heart journal 2005;149(1):20-32.
2005: Ele Ferrannini; Amalia Gastaldelli; Yoshinori Miyazaki; Masafumi Matsuda; Andrea Mari; Ralph DeFronzo
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
The Journal of clinical endocrinology and metabolism 2005;90(1):493-500.
2004: Estela Wajcberg; Yoshinori Miyazaki; Curtis Triplitt; Eugenio Cersosimo; Ralph DeFronzo
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects.
Diabetes care 2004;27(12):2868-73.
2004: Elaine Chiquette; Gilbert Ramirez; Ralph DeFronzo
A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors.
Archives of internal medicine 2004;164(19):2097-104.
2004: Ralph DeFronzo
Dysfunctional fat cells, lipotoxicity and type 2 diabetes.
International journal of clinical practice. Supplement 2004;(143):9-21.
2004: Mandeep Bajaj; Swangjit Suraamornkul; Sangeeta Kashyap; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(9):4649-55.
2004: Yoshinori Miyazaki; Archana Mahankali; Estela Wajcberg; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo
Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2004;89(9):4312-9.
2004: Sangeeta Kashyap; Renata Belfort; Rachele Berria; Swangjit Suraamornkul; Thongchai Pratipranawatr; Jean Finlayson; Andrea Barrentine; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo; Kenneth Cusi
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2004;287(3):E537-46.
2004: Amalia Gastaldelli; Yoshinori Miyazaki; Maura Pettiti; Emma Buzzigoli; Srikanth Mahankali; Ele Ferrannini; Ralph DeFronzo
Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis.
The Journal of clinical endocrinology and metabolism 2004;89(8):3914-21.
2004: Ralph DeFronzo
Pathogenesis of type 2 diabetes mellitus.
The Medical clinics of North America 2004;88(4):787-835, ix.
2004: Etta L Fanning; Beatrice J Selwyn; Anne C Larme; Ralph DeFronzo
Improving efficacy of diabetes management using treatment algorithms in a mainly Hispanic population.
Diabetes care 2004;27(7):1638-46.
2004: Mandeep Bajaj; Swangjit Suraamornkul; L Jean Hardies; Thongchai Pratipanawatr; Ralph DeFronzo
Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(6):783-9.
2004: Anthony E Civitarese; Christopher Jenkinson; D Richardson; Mandeep Bajaj; Kenneth Cusi; Sangeeta Kashyap; Rachele Berria; R Belfort; Ralph DeFronzo; Lawrence J. Manderino; Eric Ravussin
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia 2004;47(5):816-20.
2004: Harold Bays; Lawrence J. Manderino; Ralph DeFronzo
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.
The Journal of clinical endocrinology and metabolism 2004;89(2):463-78.
2004: Mandeep Bajaj; Swangjit Suraamornkul; Paul Piper; L Jean Hardies; Leonard Glass; Eugenio Cersosimo; Thongchai Pratipanawatr; Yoshinori Miyazaki; Ralph DeFronzo
Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2004;89(1):200-6.
2004: Mark E Molitch; Ralph DeFronzo; Marion J Franz; William F Keane; Carl Erik Mogensen; Hans-Henrik Parving; Michael W Steffes
Nephropathy in diabetes.
Diabetes care 2004;27 Suppl 1():S79-83.
2004: John M Adams; Thongchai Pratipanawatr; Rachele Berria; Elaine Wang; Ralph DeFronzo; M Cameron Sullards; Lawrence J. Manderino
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Diabetes 2004;53(1):25-31.
2004: Amalia Gastaldelli; Ele Ferrannini; Yoshinori Miyazaki; Masafumi Matsuda; Ralph DeFronzo
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study.
Diabetologia 2004;47(1):31-9.
2003: Saul Genuth; K G M M Alberti; Peter Bennett; John B Buse; Ralph DeFronzo; Richard Kahn; John Kitzmiller; William C Knowler; Harold E Lebovitz; Ake Lernmark; David Nathan; Jerry Palmer; Robert A Rizza; Christopher D Saudek; Jonathan Shaw; Michael Steffes; Michael P Stern; Jaako Tuomilehto; Paul Zimmet
Follow-up report on the diagnosis of diabetes mellitus.
Diabetes care 2003;26(11):3160-7.
2003: Sangeeta Kashyap; Renata Belfort; Amalia Gastaldelli; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Mandeep Bajaj; Lawrence J. Manderino; Ralph DeFronzo; Kenneth Cusi
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.
Diabetes 2003;52(10):2461-74.
2003: Ele Ferrannini; Amalia Gastaldelli; Yoshinori Miyazaki; Masafumi Matsuda; Maura Pettiti; Andrea Natali; Andrea Mari; Ralph DeFronzo
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance.
Diabetologia 2003;46(9):1211-9.
2003: Yoshinori Miyazaki; Helen He; Lawrence J. Manderino; Ralph DeFronzo
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
Diabetes 2003;52(8):1943-50.
2003: Mary-Elizabeth Patti; Atul Butte; Sarah Crunkhorn; Kenneth Cusi; Rachele Berria; Sangeeta Kashyap; Yoshinori Miyazaki; Isaac Kohane; Maura Costello; Robert Saccone; Edwin J Landaker; Allison B Goldfine; Edward C Mun; Ralph DeFronzo; Jean Finlayson; C Ronald Kahn; Lawrence J. Manderino
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8466-71.
2003: Ele Ferrannini; Amalia Gastaldelli; Masafumi Matsuda; Yoshinori Miyazaki; Maura Pettiti; Leonard Glass; Ralph DeFronzo
Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis.
The Journal of clinical endocrinology and metabolism 2003;88(7):3251-7.
2003: Mandeep Bajaj; Swangjit Suraamornkul; Thongchai Pratipanawatr; L Jean Hardies; Wilailak Pratipanawatr; Leonard Glass; Eugenio Cersosimo; Yoshinori Miyazaki; Ralph DeFronzo
Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes.
Diabetes 2003;52(6):1364-70.
2003: Mandeep Bajaj; Ralph DeFronzo
Metabolic and molecular basis of insulin resistance.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003;10(3):311-23.
2003: Gerald B Appel; Jai Radhakrishnan; Morrell M Avram; Ralph DeFronzo; Fernando Escobar-Jimenez; M M Campos; Ellen Burgess; Darcy A Hille; Tania Z Dickson; Shahnaz Shahinfar; Barry M Brenner
Analysis of metabolic parameters as predictors of risk in the RENAAL study.
Diabetes care 2003;26(5):1402-7.
2003: Ravindranath Duggirala; Laura A Almasy; John C Blangero; Christopher Jenkinson; Rector Arya; Ralph DeFronzo; Michael P Stern; Peter O'Connell
Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q.
Genetic epidemiology 2003;24(3):240-2.
2003: Yoshinori Miyazaki; R Pipek; Lawrence J. Manderino; Ralph DeFronzo
Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(1):88-94.
2003: Mark E Molitch; Ralph DeFronzo; Marion J Franz; William F Keane; Carl Erik Mogensen; Hans-Henrik Parving
Diabetic nephropathy.
Diabetes care 2003;26 Suppl 1():S94-8.
2002: Yoshinori Miyazaki; Leonard Glass; Curtis Triplitt; Estela Wajcberg; Lawrence J. Manderino; Ralph DeFronzo
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1135-43.
2002: Amalia Gastaldelli; Yoshinori Miyazaki; Maura Pettiti; Masafumi Matsuda; Srikanth Mahankali; Eleonora Santini; Ralph DeFronzo; Ele Ferrannini
Metabolic effects of visceral fat accumulation in type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2002;87(11):5098-103.
2002: Mandeep Bajaj; Thongchai Pratipanawatr; Rachele Berria; Wilailak Pratipanawatr; Sangeeta Kashyap; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.
Diabetes 2002;51(10):3043-8.
2002: Masafumi Matsuda; Ralph DeFronzo; Leonard Glass; agostino consoli; Mauro Giordano; Peter Bressler; Stefano Delprato
Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.
Metabolism: clinical and experimental 2002;51(9):1111-9.
2002: Mandeep Bajaj; Rachele Berria; Thongchai Pratipanawatr; Sangeeta Kashyap; Wilailak Pratipanawatr; Renata Belfort; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E346-52.
2002: Yoshinori Miyazaki; Archana Mahankali; Masafumi Matsuda; Srikanth Mahankali; Jean Hardies; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2002;87(6):2784-91.
2002: Thongchai Pratipanawatr; Wilailak Pratipanawatr; Clifford Rosen; Rachele Berria; Mandeep Bajaj; Kenneth Cusi; Lawrence J. Manderino; Sangeeta Kashyap; Renata Belfort; Ralph DeFronzo
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1360-8.
2002: N A Lee; Masafumi Matsuda; Peter Bressler; Thongchai Pratipanawatr; Leonard Glass; Lawrence J. Manderino; Ralph DeFronzo
Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.
Diabetes, obesity & metabolism 2002;4(3):195-200.
2002: Yoshinori Miyazaki; Masafumi Matsuda; Ralph DeFronzo
Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes.
Diabetes care 2002;25(3):517-23.
2002: Thongchai Pratipanawatr; Kenneth Cusi; Peter Ngo; Wilailak Pratipanawatr; Lawrence J. Manderino; Ralph DeFronzo
Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.
Diabetes 2002;51(2):462-8.
2001: Yoshinori Miyazaki; Leonard Glass; Curtis Triplitt; Masafumi Matsuda; Kenneth Cusi; Archana Mahankali; Srikanth Mahankali; Lawrence J. Manderino; Ralph DeFronzo
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.
Diabetologia 2001;44(12):2210-9.
2001: Wilailak Pratipanawatr; Thongchai Pratipanawatr; Kenneth Cusi; Rachele Berria; J M Adams; Christopher Jenkinson; K Maezono; Ralph DeFronzo; Lawrence J. Manderino
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes 2001;50(11):2572-8.
2001: C A Reasner; Ralph DeFronzo
Treatment of type 2 diabetes mellitus: a rational approach based on its pathophysiology.
American family physician 2001;63(9):1687-8, 1691-2, 1694.
2001: Kenneth Cusi; Thongchai Pratipanawatr; JA Koval; Richard L Printz; Hossein Ardehali; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Metabolism: clinical and experimental 2001;50(5):602-6.
2001: Patricia Iozzo; Thongchai Pratipanawatr; H Pijl; C Vogt; V Kumar; R Pipek; Masafumi Matsuda; Lawrence J. Manderino; Kenneth Cusi; Ralph DeFronzo
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E712-9.
2001: Yoshinori Miyazaki; Archana Mahankali; Masafumi Matsuda; Leonard Glass; Srikanth Mahankali; Ele Ferrannini; Kenneth Cusi; Lawrence J. Manderino; Ralph DeFronzo
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.
Diabetes care 2001;24(4):710-9.
2001: Kenneth Cusi; S Cukier; Ralph DeFronzo; M Torres; F M Puchulu; J C Redondo
Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(3):1410-7.
2000: Kenneth Cusi; Ralph DeFronzo
Recombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance.
The Journal of clinical endocrinology and metabolism 2000;85(9):3077-84.
2000: H Pijl; S Ohashi; Masafumi Matsuda; Yoshinori Miyazaki; Archana Mahankali; V Kumar; R Pipek; Patricia Iozzo; Jack Lancaster; A H Cincotta; Ralph DeFronzo
Bromocriptine: a novel approach to the treatment of type 2 diabetes.
Diabetes care 2000;23(8):1154-61.
2000: Ralph DeFronzo
Pharmacologic therapy for type 2 diabetes mellitus.
Annals of internal medicine 2000;133(1):73-4.
2000: Tapio Utriainen; S Lovisatti; Sari Mäkimattila; A Bertoldo; S Weintraub; Ralph DeFronzo; Claudio Cobelli; Hannele Yki-Järvinen
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E228-33.
2000: C Vogt; Hossein Ardehali; Patricia Iozzo; Hannele Yki-Järvinen; JA Koval; K Maezono; Merri L Pendergrass; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Regulation of hexokinase II expression in human skeletal muscle in vivo.
Metabolism: clinical and experimental 2000;49(6):814-8.
2000: Kenneth Cusi; K Maezono; A Osman; Merri L Pendergrass; Mary-Elizabeth Patti; Thongchai Pratipanawatr; Ralph DeFronzo; C R Kahn; Lawrence J. Manderino
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
The Journal of clinical investigation 2000;105(3):311-20.
2000: Mauro Giordano; Pietro Castellino; A Ohno; Ralph DeFronzo
Differential effects of amino acid and ketoacid on protein metabolism in humans.
Nutrition (Burbank, Los Angeles County, Calif.) 2000;16(1):15-21.
1999: Masafumi Matsuda; Y Liu; Srikanth Mahankali; Y Pu; Archana Mahankali; J Wang; Ralph DeFronzo; Peter Fox; J H Gao
Altered hypothalamic function in response to glucose ingestion in obese humans.
Diabetes 1999;48(9):1801-6.
1999: Masafumi Matsuda; Ralph DeFronzo
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
Diabetes care 1999;22(9):1462-70.
1999: Ralph DeFronzo
Pharmacologic therapy for type 2 diabetes mellitus.
Annals of internal medicine 1999;131(4):281-303.
1999: JA Koval; K Maezono; Mary-Elizabeth Patti; Merri L Pendergrass; Ralph DeFronzo; Lawrence J. Manderino
Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.
Medicine and science in sports and exercise 1999;31(7):998-1004.
1999: Masafumi Matsuda; Lawrence J. Manderino; Ralph DeFronzo
Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats.
Metabolism: clinical and experimental 1999;48(6):725-31.
1999: George B Kudolo; Ralph DeFronzo
Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus.
Prostaglandins & other lipid mediators 1999;57(2-3):87-98.
1999: Pietro Castellino; Livio Luzi; Mauro Giordano; Ralph DeFronzo
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
Journal of the American Society of Nephrology : JASN 1999;10(5):1050-8.
1999: Sietse Jan Koopmans; R S Kushwaha; Ralph DeFronzo
Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.
Metabolism: clinical and experimental 1999;48(3):330-7.
1999: Ralph DeFronzo
Pathogenesis of type 2 diabetes: implications for metformin.
Drugs 1999;58 Suppl 1():29-30; discussion 75-82.
1998: Michael Diamond; D Grainger; M C Diamond; Robert S Sherwin; Ralph DeFronzo
Effects of methyltestosterone on insulin secretion and sensitivity in women.
The Journal of clinical endocrinology and metabolism 1998;83(12):4420-5.
1998: M Pendergrass; E Fazioni; D Collins; Ralph DeFronzo
IGF-I increases forearm blood flow without increasing forearm glucose uptake.
The American journal of physiology 1998;275(2 Pt 1):E345-50.
1998: Riccardo C Bonadonna; M P Saccomani; Stefano Del Prato; Enzo Bonora; Ralph DeFronzo; C Cobelli
Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle.
Circulation 1998;98(3):234-41.
1998: Sietse Jan Koopmans; Brendan Leighton; Ralph DeFronzo
Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats.
Diabetologia 1998;41(7):813-20.
1998: Sietse Jan Koopmans; Marijke Frolich; E H Gribnau; R G Westendorp; Ralph DeFronzo
Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats.
The American journal of physiology 1998;274(6 Pt 1):E998-E1001.
1998: Sietse Jan Koopmans; Lawrence J. Manderino; Ralph DeFronzo
Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.
The American journal of physiology 1998;274(4 Pt 1):E642-50.
1998: Merri L Pendergrass; JA Koval; C Vogt; H Yki-Jarvinen; Patricia Iozzo; R Pipek; Hossein Ardehali; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Diabetes 1998;47(3):387-94.
1998: JA Koval; Ralph DeFronzo; RM O'Doherty; Richard L Printz; Hossein Ardehali; Daryl K Granner; Lawrence J. Manderino
Regulation of hexokinase II activity and expression in human muscle by moderate exercise.
The American journal of physiology 1998;274(2 Pt 1):E304-8.
1998: C Vogt; H Yki-Jarvinen; Patricia Iozzo; R Pipek; Merri L Pendergrass; JA Koval; Hossein Ardehali; Richard L Printz; Daryl K Granner; Ralph DeFronzo; Lawrence J. Manderino
Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo.
The Journal of clinical endocrinology and metabolism 1998;83(1):230-4.
1997: George B Kudolo; Peter Bressler; Ralph DeFronzo
Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment.
Journal of lipid mediators and cell signalling 1997;17(2):97-113.
1997: Mauro Giordano; Pietro Castellino; Anna Solini; M L Canessa; Ralph DeFronzo
Na+/Li+ and Na+/H+ countertransport activity in hypertensive non-insulin-dependent diabetic patients: role of insulin resistance and antihypertensive treatment.
Metabolism: clinical and experimental 1997;46(11):1316-23.
1997: G Gulli; L Rossetti; Ralph DeFronzo
Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non-insulin-dependent diabetic parents.
Metabolism: clinical and experimental 1997;46(10):1157-61.
1997: Sietse Jan Koopmans; L Ohman; Joseph Roscoe Haywood; Lawrence J. Manderino; Ralph DeFronzo
Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats.
Diabetes 1997;46(10):1572-8.
1997: Anna Solini; Enzo Bonora; Riccardo C Bonadonna; Pietro Castellino; Ralph DeFronzo
Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.
The Journal of clinical endocrinology and metabolism 1997;82(8):2552-8.
1997: Stefano Del Prato; M Matsuda; D C Simonson; Leif C Groop; P Sheehan; F Leonetti; Riccardo C Bonadonna; Ralph DeFronzo
Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance.
Diabetologia 1997;40(6):687-97.
1997: Ralph DeFronzo
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis.
The Netherlands journal of medicine 1997;50(5):191-7.
1997: George B Kudolo; Sietse Jan Koopmans; Joseph Roscoe Haywood; Ralph DeFronzo
Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney.
Journal of lipid mediators and cell signalling 1997;16(1):23-37.
1997: Joseph J Bahl; M Matsuda; Ralph DeFronzo; Rubin Bressler
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase.
Biochemical pharmacology 1997;53(1):67-74.
1997: Hannele Yki-Järvinen; C Vogt; Patricia Iozzo; R Pipek; MC Daniels; Antti Virkamäki; Sari Mäkimattila; Lawrence J. Manderino; Ralph DeFronzo; Donald A McClain; W K Gottschalk
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia 1997;40(1):76-81.
1996: P Bressler; Steven Bailey; M Matsuda; Ralph DeFronzo
Insulin resistance and coronary artery disease.
Diabetologia 1996;39(11):1345-50.
1996: Kenneth Cusi; agostino consoli; Ralph DeFronzo
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(11):4059-67.
1996: Ralph DeFronzo; S Del Prato
Insulin resistance and diabetes mellitus.
Journal of diabetes and its complications 1996;10(5):243-5.
1996: L J Raffel; D C Robbins; J M Norris; E Boerwinkle; Ralph DeFronzo; Steven C Elbein; W Fujimoto; C L Hanis; S E Kahn; M A Permutt; K C Chiu; J Cruz; D A Ehrmann; R P Robertson; J I Rotter; John B Buse
The GENNID Study. A resource for mapping the genes that cause NIDDM.
Diabetes care 1996;19(8):864-72.
1996: Riccardo C Bonadonna; Stefano Del Prato; Enzo Bonora; M P Saccomani; G Gulli; Andrea Natali; Silvia Frascerra; N Pecori; Ele Ferrannini; D Bier; C Cobelli; Ralph DeFronzo
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.
Diabetes 1996;45(7):915-25.
1996: C A Reasner; Ralph DeFronzo
Diabetic nephropathy--can it be prevented?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 1996;2(3):205-8.
1996: M Giordano; Pietro Castellino; Ralph DeFronzo
Differential responsiveness of protein synthesis and degradation to amino acid availability in humans.
Diabetes 1996;45(4):393-9.
1996: Hannele Yki-Järvinen; MC Daniels; Antti Virkamäki; Sari Mäkimattila; Ralph DeFronzo; Donald A McClain
Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.
Diabetes 1996;45(3):302-7.
1996: Livio Luzi; Pietro Castellino; Ralph DeFronzo
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
The American journal of physiology 1996;270(2 Pt 1):E273-81.
1996: M Giordano; L R Sanders; Pietro Castellino; M L Canessa; Ralph DeFronzo
Effect of alpha-adrenergic blockers, ACE inhibitors, and calcium channel antagonists on renal function in hypertensive non-insulin-dependent diabetic patients.
Nephron 1996;72(3):447-53.
1996: M P Saccomani; Riccardo C Bonadonna; D M Bier; Ralph DeFronzo; C Cobelli
A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study.
The American journal of physiology 1996;270(1 Pt 1):E170-85.
1995: Enzo Bonora; Rocco Micciolo; AA Ghiatas; Jack Lancaster; A Alyassin; Michele Muggeo; Ralph DeFronzo
Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements?
Metabolism: clinical and experimental 1995;44(12):1617-25.
1995: Nir Barzilai; P H Groop; L Groop; Ralph DeFronzo
A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin.
Acta diabetologica 1995;32(4):273-8.
1995: Lawrence J. Manderino; Richard L Printz; Kenneth Cusi; P Kinchington; R M O'Doherty; H Osawa; C Sewell; agostino consoli; Daryl K Granner; Ralph DeFronzo
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
The American journal of physiology 1995;269(4 Pt 1):E701-8.
1995: Michael Diamond; K Thornton; M Connolly-Diamond; Robert S Sherwin; Ralph DeFronzo
Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance.
Journal of the Society for Gynecologic Investigation 1995;2(5):708-15.
1995: Ralph DeFronzo; A M Goodman
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.
The New England journal of medicine 1995;333(9):541-9.
1995: K L Thornton; Ralph DeFronzo; Robert S Sherwin; Michael Diamond
Micronized estradiol and progesterone: effects on carbohydrate metabolism in reproductive-age women.
Journal of the Society for Gynecologic Investigation 1995;2(4):643-52.
1995: M P Saccomani; Riccardo C Bonadonna; E Caveggion; Ralph DeFronzo; C Cobelli
Bicarbonate kinetics in humans: identification and validation of a three-compartment model.
The American journal of physiology 1995;269(1 Pt 1):E183-92.
1995: M Giordano; M Matsuda; L Sanders; M L Canessa; Ralph DeFronzo
Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension.
Diabetes 1995;44(6):665-71.
1995: M Giordano; P Castellino; C A Carroll; Ralph DeFronzo
Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans.
Diabetologia 1995;38(6):732-8.
1995: Stefano Del Prato; A Riccio; S Vigili de Kreutzenberg; M Dorella; Antonio Tiengo; Ralph DeFronzo
Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake.
The American journal of physiology 1995;268(6 Pt 1):E1089-95.
1995: Enzo Bonora; G Gulli; Riccardo C Bonadonna; Stefano Del Prato; Anna Solini; Ralph DeFronzo
Insulin sensitivity is not impaired in Mexican-American women without a family history of diabetes.
Diabetes care 1995;18(6):825-33.
1995: M L Shank; Stefano Del Prato; Ralph DeFronzo
Bedtime insulin/daytime glipizide. Effective therapy for sulfonylurea failures in NIDDM.
Diabetes 1995;44(2):165-72.
1995: M Giordano; Ralph DeFronzo
Acute effect of human recombinant insulin-like growth factor I on renal function in humans.
Nephron 1995;71(1):10-5.
1994: M Giordano; Pietro Castellino; E L McConnell; Ralph DeFronzo
Effect of amino acid infusion on renal hemodynamics in humans: a dose-response study.
The American journal of physiology 1994;267(5 Pt 2):F703-8.
1994: A Mari; J Wahren; Ralph DeFronzo; E Ferrannini
Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods.
Metabolism: clinical and experimental 1994;43(11):1419-25.
1994: Ralph DeFronzo; C Reasner
The Diabetes Control and Complications Trial Study: implications for the diabetic foot.
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 1994;33(6):551-6.
1994: C A Reasner; Ralph DeFronzo
Diabetic nephropathy: pathogenetic basis for treatment.
Contemporary internal medicine 1994;6(10):30-2, 35-40.
1994: Stefano Del Prato; Frida Leonetti; D C Simonson; P Sheehan; M Matsuda; Ralph DeFronzo
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.
Diabetologia 1994;37(10):1025-35.
1994: A S Petrides; Livio Luzi; Ralph DeFronzo
Time-dependent regulation by insulin of leucine metabolism in young healthy adults.
The American journal of physiology 1994;267(3 Pt 1):E361-8.
1994: Riccardo C Bonadonna; Leif C Groop; D C Simonson; Ralph DeFronzo
Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle.
The American journal of physiology 1994;266(3 Pt 1):E501-9.
1994: Eugene J Barrett; S Bevilacqua; Ralph DeFronzo; Ele Ferrannini
Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods.
Metabolism: clinical and experimental 1994;43(3):285-92.
1994: A S Petrides; Ralph DeFronzo
Failure of glucagon to stimulate hepatic glycogenolysis in well-nourished patients with mild cirrhosis.
Metabolism: clinical and experimental 1994;43(1):85-9.
1994: P Castellino; K R Tuttle; Ralph DeFronzo
Diabetic nephropathy.
Current therapy in endocrinology and metabolism 1994;5():426-36.
1993: Riccardo C Bonadonna; Stefano Del Prato; Enzo Bonora; G Gulli; Anna Solini; Ralph DeFronzo
Effects of physiological hyperinsulinemia on the intracellular metabolic partition of plasma glucose.
The American journal of physiology 1993;265(6 Pt 1):E943-53.
1993: Livio Luzi; A S Petrides; Ralph DeFronzo
Different sensitivity of glucose and amino acid metabolism to insulin in NIDDM.
Diabetes 1993;42(12):1868-77.
1993: Riccardo C Bonadonna; Stefano Del Prato; M P Saccomani; Enzo Bonora; G Gulli; Ele Ferrannini; D Bier; C Cobelli; Ralph DeFronzo
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.
The Journal of clinical investigation 1993;92(1):486-94.
1993: Michael Diamond; Ralph Jacob; M Connolly-Diamond; Ralph DeFronzo
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp.
The Journal of reproductive medicine 1993;38(6):417-21.
1993: Enzo Bonora; Riccardo C Bonadonna; Stefano Del Prato; G Gulli; Anna Solini; M Matsuda; Ralph DeFronzo
In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension.
Diabetes 1993;42(5):764-72.
1993: Carola Saloranta; V Koivisto; Elisabeth Widén; K Falholt; Ralph DeFronzo; M Härkönen; Leif Groop
Contribution of muscle and liver to glucose-fatty acid cycle in humans.
The American journal of physiology 1993;264(4 Pt 1):E599-605.
1993: Riccardo C Bonadonna; M P Saccomani; C Cobelli; Ralph DeFronzo
Effect of insulin on system A amino acid transport in human skeletal muscle.
The Journal of clinical investigation 1993;91(2):514-21.
1993: Stefano Del Prato; Riccardo C Bonadonna; Enzo Bonora; G Gulli; Anna Solini; M Shank; Ralph DeFronzo
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.
The Journal of clinical investigation 1993;91(2):484-94.
1993: Riccardo C Bonadonna; M P Saccomani; L Seely; K S Zych; Ele Ferrannini; C Cobelli; Ralph DeFronzo
Glucose transport in human skeletal muscle. The in vivo response to insulin.
Diabetes 1993;42(1):191-8.
1992: David A Grainger; K Thornton; G Rossi; M Connoly-Diamond; Ralph DeFronzo; Robert S Sherwin; Michael Diamond
Influence of basal androgen levels in euandrogenic women on glucose homeostasis.
Fertility and sterility 1992;58(6):1113-8.
1992: G Gulli; E Ferrannini; Michael P Stern; Steven M Haffner; Ralph DeFronzo
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents.
Diabetes 1992;41(12):1575-86.
1992: Leif C Groop; Riccardo C Bonadonna; D C Simonson; A S Petrides; M Shank; Ralph DeFronzo
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.
The American journal of physiology 1992;263(1 Pt 1):E79-84.
1992: Ralph DeFronzo
Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview.
Diabetologia 1992;35(4):389-97.
1992: Ralph DeFronzo; Riccardo C Bonadonna; E Ferrannini
Pathogenesis of NIDDM. A balanced overview.
Diabetes care 1992;15(3):318-68.
1992: Pietro Castellino; Anna Solini; Livio Luzi; J G Barr; D J Smith; A Petrides; M Giordano; C Carroll; Ralph DeFronzo
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
The American journal of physiology 1992;262(2 Pt 2):F168-76.
1992: S Frontoni; L Ohman; Joseph Roscoe Haywood; Ralph DeFronzo; Luciano Rossetti
In vivo insulin action in genetic models of hypertension.
The American journal of physiology 1992;262(2 Pt 1):E191-6.
1992: Robert H Mak; Ralph DeFronzo
Glucose and insulin metabolism in uremia.
Nephron 1992;61(4):377-82.
1992: A S Petrides; Georg Strohmeyer; Ralph DeFronzo
Insulin resistance in liver disease and portal hypertension.
Progress in liver diseases 1992;10():311-28.
1992: Ralph DeFronzo
Insulin resistance, hyperinsulinemia, and coronary artery disease: a complex metabolic web.
Journal of cardiovascular pharmacology 1992;20 Suppl 11():S1-16.
1991: Ralph DeFronzo; Nir Barzilai; D C Simonson
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.
The Journal of clinical endocrinology and metabolism 1991;73(6):1294-301.
1991: A S Petrides; Livio Luzi; Adrian Reuben; C Riely; Ralph DeFronzo
Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis.
Hepatology (Baltimore, Md.) 1991;14(3):432-41.
1991: Leif C Groop; Nir Barzilai; K Ratheiser; Livio Luzi; E Wåhlin-Boll; A Melander; Ralph DeFronzo
Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans.
Diabetes care 1991;14(8):724-7.
1991: A S Petrides; Leif C Groop; C A Riely; Ralph DeFronzo
Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis.
The Journal of clinical investigation 1991;88(2):561-70.
1991: K R Tuttle; J L Bruton; M C Perusek; Jack Lancaster; D T Kopp; Ralph DeFronzo
Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus.
The New England journal of medicine 1991;324(23):1626-32.
1991: Gerald I Shulman; Ralph DeFronzo; L Rossetti
Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion.
The American journal of physiology 1991;260(5 Pt 1):E731-5.
1991: R C Bonadonna; Ralph DeFronzo
Glucose metabolism in obesity and type 2 diabetes.
Diabète & métabolisme 1991;17(1 Pt 2):112-35.
1991: Jack Lancaster; AA Ghiatas; A Alyassin; R F Kilcoyne; E Bonora; Ralph DeFronzo
Measurement of abdominal fat with T1-weighted MR images.
Journal of magnetic resonance imaging : JMRI 1991;1(3):363-9.
1991: Luciano Rossetti; S Frontoni; R Dimarchi; Ralph DeFronzo; Andrea Giaccari
Metabolic effects of IGF-I in diabetic rats.
Diabetes 1991;40(4):444-8.
1991: Michael Diamond; David A Grainger; A J Laudano; K Starick-Zych; Ralph DeFronzo
Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women.
The Journal of clinical endocrinology and metabolism 1991;72(4):883-7.
1991: Ralph DeFronzo; E Ferrannini
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.
Diabetes care 1991;14(3):173-94.
1991: K R Tuttle; Ralph DeFronzo; J H Stein
Treatment of diabetic nephropathy: a rational approach based on its pathophysiology.
Seminars in nephrology 1991;11(2):220-35.
1991: Barbara B Kahn; G I Shulman; Ralph DeFronzo; S W Cushman; L Rossetti
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
The Journal of clinical investigation 1991;87(2):561-70.
1991: Leif C Groop; Carola Saloranta; M Shank; Riccardo C Bonadonna; Ele Ferrannini; Ralph DeFronzo
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1991;72(1):96-107.
1991: Leif C Groop; Riccardo C Bonadonna; M Shank; A S Petrides; Ralph DeFronzo
Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man.
The Journal of clinical investigation 1991;87(1):83-9.
1991: A S Petrides; C A Riely; Ralph DeFronzo
Insulin resistance in noncirrhotic idiopathic portal hypertension.
Gastroenterology 1991;100(1):245-51.
1991: Leif C Groop; K Ratheiser; Livio Luzi; A Melander; D C Simonson; A Petrides; Riccardo C Bonadonna; Elisabeth Widén; Ralph DeFronzo
Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study.
Acta diabetologica 1991;28(2):162-8.
1990: Riccardo C Bonadonna; Leif C Groop; K Zych; M Shank; Ralph DeFronzo
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans.
The American journal of physiology 1990;259(5 Pt 1):E736-50.
1990: Ele Ferrannini; L D Katz; M G Glickman; Ralph DeFronzo
Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man.
Clinical physiology (Oxford, England) 1990;10(6):527-38.
1990: Pietro Castellino; Ralph DeFronzo
Glucose metabolism and the kidney.
Seminars in nephrology 1990;10(5):458-63.
1990: Leif C Groop; Riccardo C Bonadonna; S DelPrato; K Ratheiser; Ralph DeFronzo
Effect of prolonged overnight fasting on energy metabolism in non-insulin-dependent diabetic and non-diabetic subjects.
Acta endocrinologica 1990;123(1):30-6.
1990: Luciano Rossetti; Andrea Giaccari; Ralph DeFronzo
Glucose toxicity.
Diabetes care 1990;13(6):610-30.
1990: Pietro Castellino; J Shohat; Ralph DeFronzo
Hyperfiltration and diabetic nephropathy: is it the beginning? Or is it the end?
Seminars in nephrology 1990;10(3):228-41.
1990: K R Tuttle; J H Stein; Ralph DeFronzo
The natural history of diabetic nephropathy.
Seminars in nephrology 1990;10(3):184-93.
1990: Riccardo C Bonadonna; L Groop; N Kraemer; E Ferrannini; Stefano Del Prato; Ralph DeFronzo
Obesity and insulin resistance in humans: a dose-response study.
Metabolism: clinical and experimental 1990;39(5):452-9.
1990: Stefano Del Prato; Ralph DeFronzo; Pietro Castellino; J Wahren; A Alvestrand
Regulation of amino acid metabolism by epinephrine.
The American journal of physiology 1990;258(5 Pt 1):E878-87.
1990: Pietro Castellino; R Levin; J Shohat; Ralph DeFronzo
Effect of specific amino acid groups on renal hemodynamics in humans.
The American journal of physiology 1990;258(4 Pt 2):F992-7.
1990: N A Kurtzman; J Gonzalez; Ralph DeFronzo; G Giebisch
A patient with hyperkalemia and metabolic acidosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1990;15(4):333-56.
1990: L Rossetti; Ralph DeFronzo; Roberto Gherzi; P Stein; G Andraghetti; G Falzetti; G I Shulman; E Klein-Robbenhaar; Renzo Cordera
Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.
Metabolism: clinical and experimental 1990;39(4):425-35.
1990: Renzo Cordera; G Andraghetti; Ralph DeFronzo; L Rossetti
Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats.
Endocrinology 1990;126(4):2177-83.
1990: Leif Groop; A Mäkipernaa; S Stenman; Ralph DeFronzo; Anna-Maija Teppo
Urinary excretion of kappa light chains in patients with diabetes mellitus.
Kidney international 1990;37(4):1120-5.
1990: Veikko Koivisto; Hannele Yki-Järvinen; I Puhakainen; A Virkamäki; J Kolaczynski; Ralph DeFronzo
No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man.
Diabetologia 1990;33(3):168-73.
1990: DC Simonson; Ralph DeFronzo
Indirect calorimetry: methodological and interpretative problems.
The American journal of physiology 1990;258(3 Pt 1):E399-412.
1990: Pietro Castellino; M J Bia; Ralph DeFronzo
Adrenergic modulation of potassium metabolism in uremia.
Kidney international 1990;37(2):793-8.
1990: Gerald I Shulman; Douglas L Rothman; Thomas Jue; P Stein; Ralph DeFronzo; R G Shulman
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
The New England journal of medicine 1990;322(4):223-8.
1990: Livio Luzi; Pietro Castellino; D C Simonson; A S Petrides; Ralph DeFronzo
Leucine metabolism in IDDM. Role of insulin and substrate availability.
Diabetes 1990;39(1):38-48.
1990: Pietro Castellino; Livio Luzi; Stefano Del Prato; Ralph DeFronzo
Dissociation of the effects of epinephrine and insulin on glucose and protein metabolism.
The American journal of physiology 1990;258(1 Pt 1):E117-25.
1989: A S Petrides; Ralph DeFronzo
Glucose metabolism in cirrhosis: a review with some perspectives for the future.
Diabetes/metabolism reviews 1989;5(8):691-709.
1989: C Cobelli; M P Saccomani; Ele Ferrannini; Ralph DeFronzo; R Gelfand; Riccardo C Bonadonna
A compartmental model to quantitate in vivo glucose transport in the human forearm.
The American journal of physiology 1989;257(6 Pt 1):E943-58.
1989: Livio Luzi; Ralph DeFronzo
Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans.
The American journal of physiology 1989;257(2 Pt 1):E241-6.
1989: L Rossetti; Douglas L Rothman; Ralph DeFronzo; Gerald I Shulman
Effect of dietary protein on in vivo insulin action and liver glycogen repletion.
The American journal of physiology 1989;257(2 Pt 1):E212-9.
1989: Michael Diamond; D C Simonson; Ralph DeFronzo
Menstrual cyclicity has a profound effect on glucose homeostasis.
Fertility and sterility 1989;52(2):204-8.
1989: Leif C Groop; Livio Luzi; Ralph DeFronzo; A Melander
Hyperglycaemia and absorption of sulphonylurea drugs.
Lancet 1989;2(8655):129-30.
1989: Riccardo C Bonadonna; K Zych; C Boni; Ele Ferrannini; Ralph DeFronzo
Time dependence of the interaction between lipid and glucose in humans.
The American journal of physiology 1989;257(1 Pt 1):E49-56.
1989: Leif C Groop; Riccardo C Bonadonna; S DelPrato; K Ratheiser; K Zyck; Ele Ferrannini; Ralph DeFronzo
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.
The Journal of clinical investigation 1989;84(1):205-13.
1989: Thomas Jue; Douglas L Rothman; Gerald I Shulman; B A Tavitian; Ralph DeFronzo; Robert G Shulman
Direct observation of glycogen synthesis in human muscle with 13C NMR.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4489-91.
1989: P P Stein; W A Hunt; C M Johnson; Ralph DeFronzo; J D Smith
Insulin resistance in uremia: an in vivo and in vitro study.
Metabolism: clinical and experimental 1989;38(6):562-7.
1989: Ralph DeFronzo; Ele Ferrannini; D C Simonson
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.
Metabolism: clinical and experimental 1989;38(4):387-95.
1989: A S Petrides; Ralph DeFronzo
Glucose and insulin metabolism in cirrhosis.
Journal of hepatology 1989;8(1):107-14.
1988: A Golay; J P Felber; E Jequier; Ralph DeFronzo; E Ferrannini
Metabolic basis of obesity and noninsulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1988;4(8):727-47.
1988: Livio Luzi; Eugene J Barrett; L C Groop; Ele Ferrannini; Ralph DeFronzo
Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis.
Diabetes 1988;37(11):1470-7.
1988: R A Gelfand; M G Glickman; Pietro Castellino; Rita Louard; Ralph DeFronzo
Measurement of L-[1-14C]leucine kinetics in splanchnic and leg tissues in humans. Effect of amino acid infusion.
Diabetes 1988;37(10):1365-72.
1988: Pietro Castellino; C Giordano; A Perna; Ralph DeFronzo
Effects of plasma amino acid and hormone levels on renal hemodynamics in humans.
The American journal of physiology 1988;255(3 Pt 2):F444-9.
1988: Alain Golay; Ralph DeFronzo; Ele Ferrannini; D C Simonson; D Thorin; K Acheson; D Thiébaud; B Curchod; Eric Jéquier; J P Felber
Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1988;31(8):585-91.
1988: Alain Golay; Ralph DeFronzo; D Thorin; E Jequier; J P Felber
Glucose disposal in obese non-diabetic and diabetic type II patients. A study by indirect calorimetry and euglycemic insulin clamp.
Diabète & métabolisme 1988;14(4):443-51.
1988: Ralph DeFronzo
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.
Diabetes 1988;37(6):667-87.
1988: Ele Ferrannini; Ralph DeFronzo; Richard J Gusberg; J Tepler; Ralph Jacob; M Aaron; D Smith; Eugene J Barrett
Splanchnic amino acid and glucose metabolism during amino acid infusion in dogs.
Diabetes 1988;37(2):237-45.
1988: D C Simonson; L Tappy; E Jequier; J P Felber; Ralph DeFronzo
Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states.
The American journal of physiology 1988;254(2 Pt 1):E201-7.
1988: Ralph DeFronzo
Obesity is associated with impaired insulin-mediated potassium uptake.
Metabolism: clinical and experimental 1988;37(2):105-8.
1988: Anders Alvestrand; Ralph DeFronzo; D Smith; J Wahren
Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia.
Clinical science (London, England : 1979) 1988;74(2):155-63.
1988: Ele Ferrannini; D C Simonson; Lee D Katz; G Reichard; S Bevilacqua; Eugene J Barrett; M Olsson; Ralph DeFronzo
The disposal of an oral glucose load in patients with non-insulin-dependent diabetes.
Metabolism: clinical and experimental 1988;37(1):79-85.
1988: J P Felber; Alain Golay; Eric Jéquier; B Curchod; E Temler; Ralph DeFronzo; Ele Ferrannini
The metabolic consequences of long-term human obesity.
International journal of obesity 1988;12(5):377-89.
1988: Pietro Castellino; Ralph DeFronzo
Effect of plasma amino acid and hormone concentrations on renal plasma flow and glomerular filtration rate.
Blood purification 1988;6(4):240-9.
1987: Pietro Castellino; M Bia; Ralph DeFronzo
Metabolic response to exercise in dialysis patients.
Kidney international 1987;32(6):877-83.
1987: D Smith; L Rossetti; Ele Ferrannini; C M Johnson; C Cobelli; G Toffolo; Lee D Katz; Ralph DeFronzo
In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies.
Metabolism: clinical and experimental 1987;36(12):1167-74.
1987: Pietro Castellino; Livio Luzi; D C Simonson; M Haymond; Ralph DeFronzo
Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis.
The Journal of clinical investigation 1987;80(6):1784-93.
1987: Ralph DeFronzo; Robert S Sherwin; N Kraemer
Effect of physical training on insulin action in obesity.
Diabetes 1987;36(12):1379-85.
1987: Ralph DeFronzo
Use of the splanchnic/hepatic balance technique in the study of glucose metabolism.
Baillière's clinical endocrinology and metabolism 1987;1(4):837-62.
1987: J P Felber; Ele Ferrannini; A Golay; H U Meyer; D Theibaud; B Curchod; E Maeder; E Jequier; Ralph DeFronzo
Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes.
Diabetes 1987;36(11):1341-50.
1987: L Groop; Livio Luzi; A Melander; P H Groop; K Ratheiser; D C Simonson; Ralph DeFronzo
Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects.
Diabetes 1987;36(11):1320-8.
1987: Pietro Castellino; W Hunt; Ralph DeFronzo
Regulation of renal hemodynamics by plasma amino acid and hormone concentrations.
Kidney international. Supplement 1987;22():S15-20.
1987: L Rossetti; Gerald I Shulman; W Zawalich; Ralph DeFronzo
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
The Journal of clinical investigation 1987;80(4):1037-44.
1987: L Rossetti; D Smith; G I Shulman; D Papachristou; Ralph DeFronzo
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
The Journal of clinical investigation 1987;79(5):1510-5.
1987: S A Amiel; D C Simonson; W V Tamborlane; Ralph DeFronzo; Robert S Sherwin
Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans.
Diabetes 1987;36(4):518-22.
1987: Ralph DeFronzo; E Ferrannini
Regulation of hepatic glucose metabolism in humans.
Diabetes/metabolism reviews 1987;3(2):415-59.
1987: Stefano Del Prato; Pietro Castellino; D C Simonson; Ralph DeFronzo
Hyperglucagonemia and insulin-mediated glucose metabolism.
The Journal of clinical investigation 1987;79(2):547-56.
1987: D C Simonson; S Delprato; Pietro Castellino; L Groop; Ralph DeFronzo
Effect of glyburide on glycemic control, insulin requirement, and glucose metabolism in insulin-treated diabetic patients.
Diabetes 1987;36(2):136-46.
1987: L Rossetti; G Klein-Robbenhaar; G Giebisch; D Smith; Ralph DeFronzo
Effect of insulin on renal potassium metabolism.
The American journal of physiology 1987;252(1 Pt 2):F60-4.
1987: Pietro Castellino; D C Simonson; Ralph DeFronzo
Adrenergic modulation of potassium metabolism during exercise in normal and diabetic humans.
The American journal of physiology 1987;252(1 Pt 1):E68-76.
1987: P T Sager; Ralph DeFronzo
Dopaminergic regulation of extrarenal potassium metabolism.
Mineral and electrolyte metabolism 1987;13(6):385-92.
1986: Ralph DeFronzo
Conversation with ... Ralph DeFronzo, MD: dealing with the older diabetic. Interview by Richard L. Peck.
Geriatrics 1986;41(12):89-92.
1986: G Desir; P Bratusch-Marrain; Ralph DeFronzo
Effect of hyperketonemia on renal ammonia excretion in man.
Metabolism: clinical and experimental 1986;35(8):736-43.
1986: Eugene J Barrett; Richard J Gusberg; E Ferrannini; J Tepler; P Felig; R Jacob; D Smith; Ralph DeFronzo
Amino acid and glucose metabolism in the postabsorptive state and following amino acid ingestion in the dog.
Metabolism: clinical and experimental 1986;35(8):709-17.
1986: P Castellino; B Coda; Ralph DeFronzo
Effect of amino acid infusion on renal hemodynamics in humans.
The American journal of physiology 1986;251(1 Pt 2):F132-40.
1986: L Tappy; J P Randin; J P Felber; René L Chiolero; D C Simonson; E Jequier; Ralph DeFronzo
Comparison of thermogenic effect of fructose and glucose in normal humans.
The American journal of physiology 1986;250(6 Pt 1):E718-24.
1986: Ele Ferrannini; Eugene J Barrett; S Bevilacqua; R Jacob; M Walesky; Robert S Sherwin; Ralph DeFronzo
Effect of free fatty acids on blood amino acid levels in human.
The American journal of physiology 1986;250(6 Pt 1):E686-94.
1986: D Thorin; Alain Golay; D C Simonson; Eric Jéquier; J P Felber; Ralph DeFronzo
The effect of selective beta adrenergic blockade on glucose-induced thermogenesis in man.
Metabolism: clinical and experimental 1986;35(6):524-8.
1986: R A Gelfand; M G Glickman; R Jacob; Robert S Sherwin; Ralph DeFronzo
Removal of infused amino acids by splanchnic and leg tissues in humans.
The American journal of physiology 1986;250(4 Pt 1):E407-13.
1986: P R Bratusch-Marrain; Ralph DeFronzo
Failure of hyperketonemia to alter basal and insulin-mediated glucose metabolism in man.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1986;18(3):185-9.
1986: A Golay; Y Schutz; J P Felber; Ralph DeFronzo; E Jéquier
Lack of thermogenic response to glucose/insulin infusion in diabetic obese subjects.
International journal of obesity 1986;10(2):107-16.
1986: V A Koivisto; Hannele Yki-Järvinen; Ralph DeFronzo
Physical training and insulin sensitivity.
Diabetes/metabolism reviews 1986;1(4):445-81.
1986: M J Bia; D Lu; K Tyler; Ralph DeFronzo
Beta adrenergic control of extrarenal potassium disposal. A beta-2 mediated phenomenon.
Nephron 1986;43(2):117-22.
1985: Ralph DeFronzo; J D Smith
Is glucose intolerance harmful for the uremic patient?
Kidney international. Supplement 1985;17():S88-97.
1985: G I Shulman; D L Rothman; D Smith; C M Johnson; J B Blair; R G Shulman; Ralph DeFronzo
Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy.
The Journal of clinical investigation 1985;76(3):1229-36.
1985: J Rodin; J Wack; E Ferrannini; Ralph DeFronzo
Effect of insulin and glucose on feeding behavior.
Metabolism: clinical and experimental 1985;34(9):826-31.
1985: S Bevilacqua; Eugene J Barrett; D Smith; D C Simonson; M Olsson; P Bratusch-Marrain; Ele Ferrannini; Ralph DeFronzo
Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog.
Metabolism: clinical and experimental 1985;34(9):817-25.
1985: D C Simonson; W V Tamborlane; Robert S Sherwin; J D Smith; Ralph DeFronzo
Improved insulin sensitivity in patients with type I diabetes mellitus after CSII.
Diabetes 1985;34 Suppl 3():80-6.
1985: D C Simonson; W V Tamborlane; Ralph DeFronzo; Robert S Sherwin
Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes.
Annals of internal medicine 1985;103(2):184-90.
1985: E Ferrannini; J D Smith; C Cobelli; G Toffolo; A Pilo; Ralph DeFronzo
Effect of insulin on the distribution and disposition of glucose in man.
The Journal of clinical investigation 1985;76(1):357-64.
1985: Ralph DeFronzo; R Gunnarsson; O Björkman; M Olsson; J Wahren
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
The Journal of clinical investigation 1985;76(1):149-55.
1985: E Ferrannini; O Bjorkman; G A Reichard; A Pilo; M Olsson; J Wahren; Ralph DeFronzo
The disposal of an oral glucose load in healthy subjects. A quantitative study.
Diabetes 1985;34(6):580-8.
1985: Eugene J Barrett; Ele Ferrannini; R Gusberg; S Bevilacqua; Ralph DeFronzo
Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog.
Metabolism: clinical and experimental 1985;34(5):410-20.
1985: B Stanton; G Giebisch; G Klein-Robbenhaar; James B Wade; Ralph DeFronzo
Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney.
The Journal of clinical investigation 1985;75(4):1317-26.
1985: B Stanton; A Janzen; G Klein-Robbenhaar; Ralph DeFronzo; G Giebisch; James B Wade
Ultrastructure of rat initial collecting tubule. Effect of adrenal corticosteroid treatment.
The Journal of clinical investigation 1985;75(4):1327-34.
1985: M Akmal; Shaul G Massry; D A Goldstein; Paolo Fanti; A Weisz; Ralph DeFronzo
Role of parathyroid hormone in the glucose intolerance of chronic renal failure.
The Journal of clinical investigation 1985;75(3):1037-44.
1985: V A Koivisto; M Härkönen; S L Karonen; P H Groop; R Elovainio; E Ferrannini; L Sacca; Ralph DeFronzo
Glycogen depletion during prolonged exercise: influence of glucose, fructose, or placebo.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;58(3):731-7.
1984: Hannele Yki-Järvinen; Ralph DeFronzo; V A Koivisto
Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy.
Diabetes care 1984;7(6):520-7.
1984: D C Simonson; Ele Ferrannini; S Bevilacqua; D Smith; E Barrett; R Carlson; Ralph DeFronzo
Mechanism of improvement in glucose metabolism after chronic glyburide therapy.
Diabetes 1984;33(9):838-45.
1984: L D Katz; J D'Avella; Ralph DeFronzo
Effect of epinephrine on renal potassium excretion in the isolated perfused rat kidney.
The American journal of physiology 1984;247(2 Pt 2):F331-8.
1984: D C Simonson; V Koivisto; Robert S Sherwin; E Ferrannini; R Hendler; A Juhlin-Dannfelt; Ralph DeFronzo
Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.
The Journal of clinical investigation 1984;73(6):1648-58.
1984: Ralph DeFronzo; D Simonson
Diabetes in the elderly: not just "normal aging".
Geriatrics 1984;39(5):16, 19.
1984: Ralph DeFronzo; D C Simonson
Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals.
Diabetes care 1984;7 Suppl 1():72-80.
1984: E J Barrett; Ralph DeFronzo
Diabetic ketoacidosis: diagnosis and treatment.
Hospital practice (Office ed.) 1984;19(4):89-95, 99-104.
1984: Ralph DeFronzo; D Thorin; J P Felber; D C Simonson; D Thiebaud; E Jequier; Alain Golay
Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man.
The Journal of clinical investigation 1984;73(3):633-9.
1984: A Alvestrand; J Wahren; D Smith; Ralph DeFronzo
Insulin-mediated potassium uptake is normal in uremic and healthy subjects.
The American journal of physiology 1984;246(2 Pt 1):E174-80.
1984: E Ferrannini; Ralph DeFronzo
Renal handling of insulin in man.
Contributions to nephrology 1984;42():49-53.
1984: R A Gelfand; Ralph DeFronzo
Hypoglycemic counterregulation in normal and diabetic man.
Annals of clinical research 1984;16(2):84-93.
1983: Ralph DeFronzo; D Smith; A Alvestrand
Insulin action in uremia.
Kidney international. Supplement 1983;16():S102-14.
1983: M J Bia; K Tyler; Ralph DeFronzo
The effect of dexamethasone on renal potassium excretion and acute potassium tolerance.
Endocrinology 1983;113(5):1690-6.
1983: P R Bratusch-Marrain; Ralph DeFronzo
Impairment of insulin-mediated glucose metabolism by hyperosmolality in man.
Diabetes 1983;32(11):1028-34.
1983: Ele Ferrannini; Eugene J Barrett; S Bevilacqua; Ralph DeFronzo
Effect of fatty acids on glucose production and utilization in man.
The Journal of clinical investigation 1983;72(5):1737-47.
1983: J P Felber; D Thiébaud; E Maeder; Eric Jéquier; R Hendler; Ralph DeFronzo
Effect of somatostatin-induced insulinopenia on glucose oxidation in man.
Diabetologia 1983;25(4):325-30.
1983: Ralph DeFronzo; B Stanton; G Klein-Robbenhaar; G Giebisch
Inhibitory effect of epinephrine on renal potassium secretion: a micropuncture study.
The American journal of physiology 1983;245(3):F303-11.
1983: Y Schutz; D Thiébaud; K J Acheson; J P Felber; Ralph DeFronzo; E Jéquier
Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men.
Clinical nutrition (Edinburgh, Scotland) 1983;2(2):93-6.
1983: D C Simonson; Ralph DeFronzo
Glucagon physiology and aging: evidence for enhanced hepatic sensitivity.
Diabetologia 1983;25(1):1-7.
1983: L D Katz; M G Glickman; S Rapoport; E Ferrannini; Ralph DeFronzo
Splanchnic and peripheral disposal of oral glucose in man.
Diabetes 1983;32(7):675-9.
1983: E Ferrannini; J Wahren; O K Faber; P Felig; C Binder; Ralph DeFronzo
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study.
The American journal of physiology 1983;244(6):E517-27.
1983: D Thiebaud; K Acheson; Y Schutz; J P Felber; Alain Golay; Ralph DeFronzo; E Jéquier
Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion.
The American journal of clinical nutrition 1983;37(4):603-11.
1983: D Thiebaud; Y Schutz; K Acheson; E Jacot; Ralph DeFronzo; J P Felber; E Jequier
Energy cost of glucose storage in human subjects during glucose-insulin infusions.
The American journal of physiology 1983;244(3):E216-21.
1983: Ralph DeFronzo; E Ferrannini; V Koivisto
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus.
The American journal of medicine 1983;74(1A):52-81.
1983: Ralph DeFronzo; E Ferrannini; R Hendler; P Felig; J Wahren
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man.
Diabetes 1983;32(1):35-45.
1982: H Wallberg-Henriksson; R Gunnarsson; J Henriksson; Ralph DeFronzo; P Felig; J Ostman; J Wahren
Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training.
Diabetes 1982;31(12):1044-50.
1982: D Thiebaud; E Jacot; Ralph DeFronzo; E Maeder; E Jequier; J P Felber
The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man.
Diabetes 1982;31(11):957-63.
1982: D Thiébaud; Ralph DeFronzo; E Jacot; Alain Golay; K Acheson; E Maeder; Eric Jéquier; J P Felber
Effect of long chain triglyceride infusion on glucose metabolism in man.
Metabolism: clinical and experimental 1982;31(11):1128-36.
1982: P R Bratusch-Marrain; D Smith; Ralph DeFronzo
The effect of growth hormone on glucose metabolism and insulin secretion in man.
The Journal of clinical endocrinology and metabolism 1982;55(5):973-82.
1982: Eugene J Barrett; Ralph DeFronzo; S Bevilacqua; Ele Ferrannini
Insulin resistance in diabetic ketoacidosis.
Diabetes 1982;31(10):923-8.
1982: Ralph DeFronzo; D Simonson; E Ferrannini
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1982;23(4):313-9.
1982: J M Bia; K Tyler; Ralph DeFronzo
The effect of dexamethasone on renal electrolyte excretion in the adrenalectomized rat.
Endocrinology 1982;111(3):882-8.
1982: Ralph DeFronzo; R Hendler; D Simonson
Insulin resistance is a prominent feature of insulin-dependent diabetes.
Diabetes 1982;31(9):795-801.
1982: E Jacot; Ralph DeFronzo; Eric Jéquier; E Maeder; J P Felber
The effect of hyperglycemia, hyperinsulinemia, and route of glucose administration on glucose oxidation and glucose storage.
Metabolism: clinical and experimental 1982;31(9):922-30.
1982: Ralph DeFronzo; E Ferrannini
Influence of plasma glucose and insulin concentration on plasma glucose clearance in man.
Diabetes 1982;31(8 Pt 1):683-8.
1982: J Wahren; A Juhlin-Dannfelt; O Björkman; Ralph DeFronzo; P Felig
Influence of fibre ingestion on carbohydrate utilization and absorption.
Clinical physiology (Oxford, England) 1982;2(4):315-21.
1982: D Smith; Ralph DeFronzo
Insulin resistance in uremia mediated by postbinding defects.
Kidney international 1982;22(1):54-62.
1982: M J Bia; K A Tyler; Ralph DeFronzo
Regulation of extrarenal potassium homeostasis by adrenal hormones in rats.
The American journal of physiology 1982;242(6):F641-4.
1982: Ralph DeFronzo; E Ferrannini
The pathogenesis of non-insulin-dependent diabetes: an update.
Medicine 1982;61(3):125-40.
1982: E Ferrannini; Ralph DeFronzo; Robert S Sherwin
Transient hepatic response to glucagon in man: role of insulin and hyperglycemia.
The American journal of physiology 1982;242(2):E73-81.
1982: Ele Ferrannini; E Barrett; S Bevilacqua; J Dupre; Ralph DeFronzo
Sodium elevates the plasma glucose response to glucose ingestion in man.
The Journal of clinical endocrinology and metabolism 1982;54(2):455-8.
1982: Ralph DeFronzo; S O Thier
Inherited tubule disorders.
Hospital practice (Office ed.) 1982;17(2):111-7, 121-8.
1982: V A Koivisto; Ralph DeFronzo; R Hendler; P Felig
The difference in insulin sensitivity and metabolic response to acute exercise in trained and sedentary subjects.
Current problems in clinical biochemistry 1982;11():122-32.
1982: Ralph DeFronzo; M Bia; D Smith
Clinical disorders of hyperkalemia.
Annual review of medicine 1982;33():521-54.
1982: D Simonson; Ralph DeFronzo
Hypophosphatemia and glucose intolerance.
Advances in experimental medicine and biology 1982;151():217-28.
1982: Ralph DeFronzo
Insulin secretion, insulin resistance, and obesity.
International journal of obesity 1982;6 Suppl 1():73-82.
1981: Ralph DeFronzo; E Ferrannini; Y Sato; P Felig; J Wahren
Synergistic interaction between exercise and insulin on peripheral glucose uptake.
The Journal of clinical investigation 1981;68(6):1468-74.
1981: Ralph DeFronzo; E Jacot; E Jequier; E Maeder; J Wahren; J P Felber
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization.
Diabetes 1981;30(12):1000-7.
1981: Ralph DeFronzo
The effect of insulin on renal sodium metabolism. A review with clinical implications.
Diabetologia 1981;21(3):165-71.
1981: Ralph DeFronzo; C Binder; J Wahren; P Felig; E Ferrannini; O K Faber
Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia.
Acta endocrinologica 1981;98(1):81-6.
1981: Ralph DeFronzo; M Bia; G Birkhead
Epinephrine and potassium homeostasis.
Kidney international 1981;20(1):83-91.
1981: Ralph DeFronzo
Glucose intolerance and aging.
Diabetes care 1981;4(4):493-501.
1981: S Bevilacqua; E Barrett; Ele Ferrannini; R Gusberg; A Stewart; L Richardson; D Smith; Ralph DeFronzo
Lack of effect of parathyroid hormone on hepatic glucose metabolism in the dog.
Metabolism: clinical and experimental 1981;30(5):469-75.
1981: M J Bia; Ralph DeFronzo
Extrarenal potassium homeostasis.
The American journal of physiology 1981;240(4):F257-68.
1981: Ralph DeFronzo; A Alvestrand; D Smith; R Hendler; E Hendler; J Wahren
Insulin resistance in uremia.
The Journal of clinical investigation 1981;67(2):563-8.
1981: Ralph DeFronzo
Insulin and renal sodium handling: clinical implications.
International journal of obesity 1981;5 suppl 1():93-104.
1981: Ralph DeFronzo; D Simonson; E Ferrannini; E Barrett
Insulin resistance: a universal finding in diabetic states.
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften 1981;():223-38.
1980: Ralph DeFronzo; R Lang
Hypophosphatemia and glucose intolerance: evidence for tissue insensitivity to insulin.
The New England journal of medicine 1980;303(22):1259-63.
1980: Howard Rasmussen; R Baron; A Broadus; Ralph DeFronzo; R Lang; R Horst
1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia.
The American journal of medicine 1980;69(3):360-8.
1980: Ralph DeFronzo
Retraction. Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man.
Diabetes 1980;29(8):672.
1980: Ralph DeFronzo; S O Thier
Pathophysiologic approach to hyponatremia.
Archives of internal medicine 1980;140(7):897-902.
1980: Ralph DeFronzo; A Alvestrand
Glucose intolerance in uremia: site and mechanism.
The American journal of clinical nutrition 1980;33(7):1438-45.
1980: Ralph DeFronzo; P Felig
Amino acid metabolism in uremia: insights gained from normal and diabetic man.
The American journal of clinical nutrition 1980;33(7):1378-86.
1980: Ralph DeFronzo; P Felig; E Ferrannini; J Wahren
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man.
The American journal of physiology 1980;238(5):E421-7.
1980: Ralph DeFronzo; R Lee; A Jones; M Bia
Effect of insulinopenia and adrenal hormone deficiency on acute potassium tolerance.
Kidney international 1980;17(5):586-94.
1980: D C Deibert; Ralph DeFronzo
Epinephrine-induced insulin resistance in man.
The Journal of clinical investigation 1980;65(3):717-21.
1980: IRA MANDELL; Ralph DeFronzo; Gray L Robertson; J N Forrest
Role of plasma arginine vasopressin in the impaired water diuresis of isolated glucocorticoid deficiency in the rat.
Kidney international 1980;17(2):186-95.
1980: V R Soman; Ralph DeFronzo
Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man.
Diabetes 1980;29(2):159-63.
1980: Ralph DeFronzo; R Hendler; N Christensen
Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration.
Diabetes 1980;29(2):125-31.
1980: E Ferrannini; J Wahren; P Felig; Ralph DeFronzo
The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man.
Metabolism: clinical and experimental 1980;29(1):28-35.
1980: V A Koivisto; V R Soman; Ralph DeFronzo; P Felig
Effects of acute exercise and training on insulin binding to monocytes and insulin sensitivity in vivo.
Acta paediatrica Scandinavica. Supplement 1980;283():70-8.
1980: Ralph DeFronzo
Hyperkalemia and hyporeninemic hypoaldosteronism.
Kidney international 1980;17(1):118-34.
1980: Ralph DeFronzo; Robert S Sherwin; P Felig
Synergistic interactions of counterregulatory hormones: a mechanism for stress hyperglycemia.
Acta chirurgica Scandinavica. Supplementum 1980;498():33-42.
1979: Ralph DeFronzo
Glucose intolerance and aging: evidence for tissue insensitivity to insulin.
Diabetes 1979;28(12):1095-101.
1979: V R Soman; V A Koivisto; D Deibert; P Felig; Ralph DeFronzo
Increased insulin sensitivity and insulin binding to monocytes after physical training.
The New England journal of medicine 1979;301(22):1200-4.
1979: Ralph DeFronzo; Jordan Tobin; G Boden; Reubin Andres
The role of growth hormone in the glucose intolerance of uremia.
Acta diabetologica latina 1979;16(4):279-86.
1979: Ralph DeFronzo; Jordan Tobin; Reubin Andres
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
The American journal of physiology 1979;237(3):E214-23.
1979: R Mahnensmith; S O Thier; C R Cooke; A Broadus; Ralph DeFronzo
Effect of acute metabolic acidemia on renal electrolyte transport in man.
Metabolism: clinical and experimental 1979;28(8):831-42.
1979: Ralph DeFronzo; D Deibert; R Hendler; P Felig; V Soman
Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes.
The Journal of clinical investigation 1979;63(5):939-46.
1979: Ralph DeFronzo; A D Beckles
Glucose intolerance following chronic metabolic acidosis in man.
The American journal of physiology 1979;236(4):E328-34.
1979: Ralph DeFronzo; P A Taufield; H Black; P McPhedran; C R Cooke
Impaired renal tubular potassium secretion in sickle cell disease.
Annals of internal medicine 1979;90(3):310-16.
1979: R J Gusberg; E Barrett; P Felig; Ralph DeFronzo
Hepatic response to enteral and parenteral glucose in the dog.
Surgical forum 1979;30():74-5.
1978: Ralph DeFronzo
Pathogenesis of glucose intolerance in uremia.
Metabolism: clinical and experimental 1978;27(12 Suppl 2):1866-80.
1978: V Soman; W Tamborlane; Ralph DeFronzo; M Genel; P Felig
Insulin binding and insulin sensitivity in isolated growth hormone deficiency.
The New England journal of medicine 1978;299(19):1025-30.
1978: Ralph DeFronzo; E Ferrannini; R Hendler; J Wahren; P Felig
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(10):5173-7.
1978: Ralph DeFronzo; Jordan Tobin; J W Rowe; Reubin Andres
Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin.
The Journal of clinical investigation 1978;62(2):425-35.
1978: Ralph DeFronzo; V Soman; Robert S Sherwin; R Hendler; P Felig
Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding.
The Journal of clinical investigation 1978;62(1):204-13.
1978: Ralph DeFronzo; C R Cooke; J R Wright; RICHARD HUMPHREY
Renal function in patients with multiple myeloma.
Medicine 1978;57(2):151-66.
1978: Ralph DeFronzo; Robert S Sherwin; M Dillingham; R Hendler; W V Tamborlane; P Felig
Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings.
The Journal of clinical investigation 1978;61(2):472-9.
1977: Robert S Sherwin; W Tamborlane; R Hendler; L Saccá; Ralph DeFronzo; P Felig
Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man.
The Journal of clinical endocrinology and metabolism 1977;45(5):1104-7.
1977: Ralph DeFronzo; Robert S Sherwin; P Felig; M Bia
Nonuremic diabetic hyperkalemia. Possible role of insulin deficiency.
Archives of internal medicine 1977;137(7):842-3.
1977: Ralph DeFronzo; Reubin Andres; T A Bedsoe; G Boden; G A Faloona; Jordan Tobin
A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man.
Diabetes 1977;26(5):445-52.
1977: Ralph DeFronzo; M Goldberg; C R Cooke; C Barker; R A Grossman; Z S Agus
Investigations into the mechanisms of hyperkalemia following renal transplantation.
Kidney international 1977;11(5):357-65.
1977: Ralph DeFronzo; C R Cooke; M Goldberg; M Cox; A R Myers; Z S Agus
Impaired renal tubular potassium secretion in systemic lupus erythematosus.
Annals of internal medicine 1977;86(3):268-71.
1977: Robert S Sherwin; R Hendler; Ralph DeFronzo; J Wahren; P Felic
Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(1):348-52.
1976: Ralph DeFronzo; N J Siegel; H A Pearson
More on the pathogenesis and management of hyponatremia in the crisis of sickle cell disease.
The Journal of pediatrics 1976;89(6):1038-40.
1976: K Lau; Ralph DeFronzo; G Morrison; J Rascoff; M Goldberg; Z S Agus
Effectiveness of bumetanide in nephrotic syndrome: a double-blind crossover study with furosemide.
Journal of clinical pharmacology 1976;16(10 Pt 1):489-97.
1976: Ralph DeFronzo; M Goldberg; Z S Agus
The effects of glucose and insulin on renal electrolyte transport.
The Journal of clinical investigation 1976;58(1):83-90.
1976: Ralph DeFronzo; M Goldberg; Z S Agus
Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
Annals of internal medicine 1976;84(5):538-42.
1976: J W Rowe; N W Shock; Ralph DeFronzo
The influence of age on the renal response to water deprivation in man.
Nephron 1976;17(4):270-8.
1976: Ralph DeFronzo; S O Thier
Functional abnormalities in renal cystic diseases.
Perspectives in nephrology and hypertension 1976;4():65-81.
1975: RICHARD HUMPHREY; J R Wright; J B Zachary; S Sterioff; Ralph DeFronzo
Renal transplantation in multiple myeloma. A case report.
Annals of internal medicine 1975;83(5):651-3.
1975: Ralph DeFronzo; RICHARD HUMPHREY; J R Wright; C R Cooke
Acute renal failure in multiple myeloma.
Medicine 1975;54(3):209-23.
1975: Ralph DeFronzo; C R Cooke; Reubin Andres; G R Faloona; P J Davis
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
The Journal of clinical investigation 1975;55(4):845-55.
1974: P G Fishbein; D K McCurdy; Ralph DeFronzo; J J Murphy
Irreversible bilateral ureteral obstruction from intravesical formaldehyde solution.
JAMA : the journal of the American Medical Association 1974;228(7):872.
1974: Ralph DeFronzo; M Abeloff; H Braine; RICHARD HUMPHREY; P J Davis
Renal dysfunction after treatment with isophosphamide (NSC-109724).
Cancer chemotherapy reports. Part 1 1974;58(3):375-82.
1974: Ralph DeFronzo; O M Colvin; H Braine; Gray L Robertson; P J Davis
Proceedings: Cyclophosphamide and the kidney.
Cancer 1974;33(2):483-91.
1973: T H Steel; A A Serpick; J B Block; Ralph DeFronzo; P J Davis; O M Colvin; H Braine
Letter: Water intoxication and cyclophosphamide.
Annals of internal medicine 1973;79(5):763-4.
1973: Ralph DeFronzo; Reubin Andres; P Edgar; W G Walker
Carbohydrate metabolism in uremia: a review.
Medicine 1973;52(5):469-81.
1973: Ralph DeFronzo; H Braine; M Colvin; P J Davis
Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation.
Annals of internal medicine 1973;78(6):861-9.
1973: Ralph DeFronzo; G F Murray; W C Maddrey
Aeromonas septicemia from hepatobiliary disease.
The American journal of digestive diseases 1973;18(4):323-31.
1972: Ralph DeFronzo; W D Roth
Evidence for the existence of a pineal-adrenal and a pineal-thyroid axis.
Acta endocrinologica 1972;70(1):35-42.
1971: Ralph DeFronzo; W D Roth; R O Greep
Lack of effect of pinealectomy on ovarian function: evidence for a time-dependent action.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1971;138(3):1058-61.
1967: Ralph DeFronzo; E Miki; J Steinke
[Diabetic syndrome in sand rats. 3. Observations on adipose tissue and liver in the non-diabetic stage].
Diabetologia 1967;3(2):140-2.