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Ralph DeFronzo

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Disorders

Devices

Glucose Clamp Technique

Anatomy

Procedures

Glucose Tolerance Test

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Activities & Behaviors

Fasting

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Co-Publications
Name
42
Mandarino, Lawrence
38
Ferrannini, Ele
29
Cusi, Kenneth
25
Bonadonna, Riccardo
25
Castellino, Pietro
24
Miyazaki, Yoshinori
21
Abdul-Ghani, Muhammad
19
Gastaldelli, Amalia
18
Berria, Rachele
18
Matsuda, Masafumi
18
Sherwin, Robert
17
Jenkinson, Christopher
17
Bajaj, Mandeep
16
Pratipanawatr, Thongchai
15
Cersosimo, Eugenio

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Publications

TOP 3
Monroy A; Kamath S; Chavez A O; Centonze V E; Veerasamy M; Barrentine A; Wewer J J; Coletta D K; Jenkinson C; Jhingan R M; Smokler D; Reyna S; Musi N; Khokka R; Federici M; Tripathy D; DeFronzo R A; Folli F
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Chavez Alberto O; Molina-Carrion Marjorie; Abdul-Ghani Muhammad A; Folli Franco; Defronzo Ralph A; Tripathy Devjit
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.
DeFronzo Ralph A; Abdul-Ghani Muhammad A
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al.

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All Publications

2009: Monroy A; Kamath S; Chavez A O; Centonze V E; Veerasamy M; Barrentine A; Wewer J J; Coletta D K; Jenkinson C; Jhingan R M; Smokler D; Reyna S; Musi N; Khokka R; Federici M; Tripathy D; DeFronzo R A; Folli F
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Diabetologia 2009;52(10):2169-81.
2009: Chavez Alberto O; Molina-Carrion Marjorie; Abdul-Ghani Muhammad A; Folli Franco; Defronzo Ralph A; Tripathy Devjit
Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance.
Diabetes care 2009;32(8):1542-6.
2009: DeFronzo Ralph A; Abdul-Ghani Muhammad A
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels: response to Utzschneider et al.
Diabetes care 2009;32(7):e86; author reply e87.
2009: Abdul-Ghani Muhammad A; DeFronzo Ralph A
Pathophysiology of prediabetes.
Current diabetes reports 2009;9(3):193-9.
2009: Defronzo Ralph A
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
Diabetes 2009;58(4):773-95.
2009: Liang Huiyun; Balas Bogdan; Tantiwong Puntip; Dube John; Goodpaster Bret H; O'Doherty Robert M; DeFronzo Ralph A; Richardson Arlan; Musi Nicolas; Ward Walter F
Whole body overexpression of PGC-1alpha has opposite effects on hepatic and muscle insulin sensitivity.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E945-54.
2009: Chavez Alberto O; Coletta Dawn K; Kamath Subhash; Cromack Douglas T; Monroy Adriana; Folli Franco; DeFronzo Ralph A; Tripathy Devjit
Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E758-64.
2009: Abdul-Ghani M A; Jani R; Chavez A; Molina-Carrion M; Tripathy D; Defronzo R A
Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.
Diabetologia 2009;52(4):574-82.
2009: Coletta D K; Sriwijitkamol A; Wajcberg E; Tantiwong P; Li M; Prentki M; Madiraju M; Jenkinson C P; Cersosimo E; Musi N; Defronzo R A
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
Diabetologia 2009;52(4):723-32.
2009: Abdul-Ghani Muhammad A; Lyssenko Valeriya; Tuomi Tiinamaija; DeFronzo Ralph A; Groop Leif
Fasting versus postload plasma glucose concentration and the risk for future type 2 diabetes: results from the Botnia Study.
Diabetes care 2009;32(2):281-6.
2009: Haus Jacob M; Kashyap Sangeeta R; Kasumov Takhar; Zhang Renliang; Kelly Karen R; Defronzo Ralph A; Kirwan John P
Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance.
Diabetes 2009;58(2):337-43.
2009: Coletta Dawn K; Schneider Jennifer; Hu Shirley L; Dyer Thomas D; Puppala Sobha; Farook Vidya S; Arya Rector; Lehman Donna M; Blangero John; DeFronzo Ralph A; Duggirala Ravindranath; Jenkinson Christopher P
Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study.
Diabetes 2009;58(1):279-84.
2009: Gastaldelli Amalia; Perego Lucia; Paganelli Michele; Sesti Giorgio; Hribal Marta; Chavez Alberto O; Defronzo Ralph A; Pontiroli Antonio; Folli Franco
Elevated concentrations of liver enzymes and ferritin identify a new phenotype of insulin resistance: effect of weight loss after gastric banding.
Obesity surgery 2009;19(1):80-6.
2009: Miyazaki Yoshinori; DeFronzo Ralph A
Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body type.
Cardiovascular diabetology 2009;8():44.
2009: Defronzo Ralph A; Banerji Maryann; Bray George A; Buchanan Thomas A; Clement Stephen; Henry Robert R; Kitabchi Abbas E; Mudaliar Sunder; Musi Nicolas; Ratner Robert; Reaven Peter D; Schwenke Dawn; Stentz Frankie B; Tripathy Devjit
Actos Now for the prevention of diabetes (ACT NOW) study.
BMC endocrine disorders 2009;9():17.
2009: Chavez Alberto O; Gastaldelli Amalia; Guardado-Mendoza Rodolfo; Lopez-Alvarenga Juan C; Leland M Michelle; Tejero M Elizabeth; Sorice GianPio; Casiraghi Francesca; Davalli Alberto; Bastarrachea Raúl A; Comuzzie Anthony G; DeFronzo Ralph A; Folli Franco
Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons.
Cardiovascular diabetology 2009;8():22.
2008: DeFronzo Ralph A; Fleck Penny R; Wilson Craig A; Mekki Qais;
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes and inadequate glycemic control: a randomized, double-blind, placebo-controlled study.
Diabetes care 2008;31(12):2315-7.
2008: Miyazaki Y; DeFronzo R A
Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients.
Diabetes, obesity & metabolism 2008;10(12):1204-11.
2008: Abdul-Ghani M A; Matsuda M; DeFronzo R A
Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(11):1289-94.
2008: Rosenstock Julio; Bergenstal Richard; Defronzo Ralph A; Hirsch Irl B; Klonoff David; Boss Anders H; Kramer David; Petrucci Richard; Yu Wen; Levy Brian;
Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents.
Diabetes care 2008;31(11):2177-82.
2008: DeFronzo Ralph A; Okerson Ted; Viswanathan Prabhakar; Guan Xuesong; Holcombe John H; MacConell Leigh
Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study.
Current medical research and opinion 2008;24(10):2943-52.
2008: Reyna Sara M; Ghosh Sangeeta; Tantiwong Puntip; Meka C S Reddy; Eagan Phyllis; Jenkinson Christopher P; Cersosimo Eugenio; Defronzo Ralph A; Coletta Dawn K; Sriwijitkamol Apiradee; Musi Nicolas
Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.
Diabetes 2008;57(10):2595-602.
2008: Abdul-Ghani Muhammad A; DeFronzo Ralph A
Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2008;14(6):782-90.
2008: Abdul-Ghani Muhammad A; Muller Florian L; Liu Yuhong; Chavez Alberto O; Balas Bogdan; Zuo Pengou; Chang Zhi; Tripathy Devjit; Jani Rucha; Molina-Carrion Marjorie; Monroy Adriana; Folli Franco; Van Remmen Holly; DeFronzo Ralph A
Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E678-85.
2008: Abdul-Ghani Muhammad A; Molina-Carrion Marjorie; Jani Rucha; Jenkinson Christopher; Defronzo Ralph A
Adipocytes in subjects with impaired fasting glucose and impaired glucose tolerance are resistant to the anti-lipolytic effect of insulin.
Acta diabetologica 2008;45(3):147-50.
2008: Positano Vincenzo; Cusi Kenneth; Santarelli Maria Filomena; Sironi Annamaria; Petz Roberta; Defronzo Ralph; Landini Luigi; Gastaldelli Amalia
Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI.
Journal of magnetic resonance imaging : JMRI 2008;28(2):403-10.
2008: Abdul-Ghani Muhammad A; Matsuda Masafumi; Jani Rucha; Jenkinson Christopher P; Coletta Dawn K; Kaku Kohei; DeFronzo Ralph A
The relationship between fasting hyperglycemia and insulin secretion in subjects with normal or impaired glucose tolerance.
American journal of physiology. Endocrinology and metabolism 2008;295(2):E401-6.
2008: Abdul-Ghani Muhammad A; Abdul-Ghani Tamam; Ali Nibal; Defronzo Ralph A
One-hour plasma glucose concentration and the metabolic syndrome identify subjects at high risk for future type 2 diabetes.
Diabetes care 2008;31(8):1650-5.
2008: Miyazaki Yoshinori; Akasaka Hiroshi; Ohnishi Hirofumi; Saitoh Shigeyuki; DeFronzo Ralph A; Shimamoto Kazuaki
Differences in insulin action and secretion, plasma lipids and blood pressure levels between impaired fasting glucose and impaired glucose tolerance in Japanese subjects.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(7):1357-63.
2008: Jenkinson Christopher P; Coletta Dawn K; Flechtner-Mors Marion; Hu Shirley L; Fourcaudot Marcel J; Rodriguez Lenore M; Schneider Jennifer; Arya Rector; Stern Michael P; Blangero John; Duggirala Ravindranath; DeFronzo Ralph A
Association of genetic variation in ENPP1 with obesity-related phenotypes.
Obesity (Silver Spring, Md.) 2008;16(7):1708-13.
2008: Abdul-Ghani Muhammad A; DeFronzo Ralph A
Mitochondrial dysfunction, insulin resistance, and type 2 diabetes mellitus.
Current diabetes reports 2008;8(3):173-8.
2008: Cervera Antonio; Wajcberg Estela; Sriwijitkamol Apiradee; Fernandez Marianella; Zuo Pengou; Triplitt Curtis; Musi Nicolas; DeFronzo Ralph A; Cersosimo Eugenio
Mechanism of action of exenatide to reduce postprandial hyperglycemia in type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E846-52.
2008: Coletta Dawn K; Balas Bogdan; Chavez Alberto O; Baig Muhammad; Abdul-Ghani Muhammad; Kashyap Sangeeta R; Folli Franco; Tripathy Devjit; Mandarino Lawrence J; Cornell John E; Defronzo Ralph A; Jenkinson Christopher P
Effect of acute physiological hyperinsulinemia on gene expression in human skeletal muscle in vivo.
American journal of physiology. Endocrinology and metabolism 2008;294(5):E910-7.
2008: Betteridge D John; DeFronzo Ralph A; Chilton Robert J
PROactive: time for a critical appraisal.
European heart journal 2008;29(8):969-83.
2008: Chavez Alberto O; Lopez-Alvarenga Juan C; Tejero M Elizabeth; Triplitt Curtis; Bastarrachea Raul A; Sriwijitkamol Apiradee; Tantiwong Puntip; Voruganti V Saroja; Musi Nicolas; Comuzzie Anthony G; DeFronzo Ralph A; Folli Franco
Physiological and molecular determinants of insulin action in the baboon.
Diabetes 2008;57(4):899-908.
2008: Jani Rucha; Molina Marjorie; Matsuda Masafumi; Balas Bogdan; Chavez Alberto; DeFronzo Ralph A; Abdul-Ghani Muhammad
Decreased non-insulin-dependent glucose clearance contributes to the rise in fasting plasma glucose in the nondiabetic range.
Diabetes care 2008;31(2):311-5.
2008: Thomaseth Karl; Pavan Alessandra; Berria Rachele; Glass Leonard; DeFronzo Ralph; Gastaldelli Amalia
Model-based assessment of insulin sensitivity of glucose disposal and endogenous glucose production from double-tracer oral glucose tolerance test.
Computer methods and programs in biomedicine 2008;89(2):132-40.
2008: Schneider Christian A; Ferrannini Ele; Defronzo Ralph; Schernthaner Guntram; Yates John; Erdmann Erland
Effect of pioglitazone on cardiovascular outcome in diabetes and chronic kidney disease.
Journal of the American Society of Nephrology : JASN 2008;19(1):182-7.
2008: Kashyap Sangeeta R; Lara Abigail; Zhang Renliang; Park Young Mi; DeFronzo Ralph A
Insulin reduces plasma arginase activity in type 2 diabetic patients.
Diabetes care 2008;31(1):134-9.
2008: Fernandez Marianella; Triplitt Curtis; Wajcberg Estela; Sriwijilkamol Apiradee A; Musi Nicholas; Cusi Kenneth; DeFronzo Ralph; Cersosimo Eugenio
Addition of pioglitazone and ramipril to intensive insulin therapy in type 2 diabetic patients improves vascular dysfunction by different mechanisms.
Diabetes care 2008;31(1):121-7.
2007: Miyazaki Y; Cersosimo E; Triplitt C; DeFronzo R A
Rosiglitazone decreases albuminuria in type 2 diabetic patients.
Kidney international 2007;72(11):1367-73.
2007: Wang Lixin; Balas Bogdan; Christ-Roberts Christine Y; Kim Ryang Yeo; Ramos Fresnida J; Kikani Chintan K; Li Cuiling; Deng Chuxia; Reyna Sara; Musi Nicolas; Dong Lily Q; DeFronzo Ralph A; Liu Feng
Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo.
Molecular and cellular biology 2007;27(18):6497-505.
2007: Berria R; Glass L; Mahankali A; Miyazaki Y; Monroy A; De Filippis E; Cusi K; Cersosimo E; Defronzo R A; Gastaldelli A
Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus.
Clinical pharmacology and therapeutics 2007;82(3):275-81.
2007: Gastaldelli Amalia; Cusi Kenneth; Pettiti Maura; Hardies Jean; Miyazaki Yoshinori; Berria Rachele; Buzzigoli Emma; Sironi Anna Maria; Cersosimo Eugenio; Ferrannini Ele; Defronzo Ralph A
Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.
Gastroenterology 2007;133(2):496-506.
2007: Bajaj M; Suraamornkul S; Hardies L J; Glass L; Musi N; DeFronzo R A
Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus.
Diabetologia 2007;50(8):1723-31.
2007: Abdul-Ghani Muhammad A; Williams Ken; DeFronzo Ralph A; Stern Michael
What is the best predictor of future type 2 diabetes?
Diabetes care 2007;30(6):1544-8.
2007: Abdul-Ghani Muhammad; DeFronzo Ralph A
Fasting hyperglycemia impairs glucose- but not insulin-mediated suppression of glucagon secretion.
The Journal of clinical endocrinology and metabolism 2007;92(5):1778-84.
2007: Coletta Dawn K; Schneider Jennifer; Stern Michael P; Blangero John; DeFronzo Ralph A; Duggirala Ravindranath; Jenkinson Christopher P
Association of neuropeptide Y receptor Y5 polymorphisms with dyslipidemia in Mexican Americans.
Obesity (Silver Spring, Md.) 2007;15(4):809-15.
2007: Balas Bogdan; Baig Muhammad R; Watson Catherine; Dunning Beth E; Ligueros-Saylan Monica; Wang Yibin; He Yan-Ling; Darland Celia; Holst Jens J; Deacon Carolyn F; Cusi Kenneth; Mari Andrea; Foley James E; DeFronzo Ralph A
The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2007;92(4):1249-55.
2007: Wajcberg Estela; Sriwijitkamol Apiradee; Musi Nicolas; DeFronzo Ralph A; Cersosimo Eugenio
Relationship between vascular reactivity and lipids in Mexican-Americans with type 2 diabetes treated with pioglitazone.
The Journal of clinical endocrinology and metabolism 2007;92(4):1256-62.
2007: Kashyap Sangeeta R; Defronzo Ralph A
The insulin resistance syndrome: physiological considerations.
Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease 2007;4(1):13-9.
2007: Sriwijitkamol Apiradee; Coletta Dawn K; Wajcberg Estela; Balbontin Gabriela B; Reyna Sara M; Barrientes John; Eagan Phyllis A; Jenkinson Christopher P; Cersosimo Eugenio; DeFronzo Ralph A; Sakamoto Kei; Musi Nicolas
Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study.
Diabetes 2007;56(3):836-48.
2007: Bajaj Mandeep; Medina-Navarro Rafael; Suraamornkul Swangjit; Meyer Christian; DeFronzo Ralph A; Mandarino Lawrence J
Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.
Diabetes 2007;56(3):743-52.
2007: Nathan David M; Davidson Mayer B; DeFronzo Ralph A; Heine Robert J; Henry Robert R; Pratley Richard; Zinman Bernard;
Impaired fasting glucose and impaired glucose tolerance: implications for care.
Diabetes care 2007;30(3):753-9.
2007: Gastaldelli Amalia; Ferrannini Ele; Miyazaki Yoshinori; Matsuda Masafumi; Mari Andrea; DeFronzo Ralph A
Thiazolidinediones improve beta-cell function in type 2 diabetic patients.
American journal of physiology. Endocrinology and metabolism 2007;292(3):E871-83.
2007: Hendee William R; Banovac Filip; Carson Paul L; DeFronzo Ralph A; Eckelman William C; Fullerton Gary D; Larson Steven M; McLennan Gordon; Welch Michael J
Biomedical imaging research opportunities workshop IV: a white paper.
Medical physics 2007;34(2):673-9.
2007: Abdul-Ghani Muhammad A; Matsuda Masafumi; Balas Bogdan; DeFronzo Ralph A
Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test.
Diabetes care 2007;30(1):89-94.
2007: Jani Rucha; Triplitt Curtis; Reasner Charles; Defronzo Ralph A
First approved inhaled insulin therapy for diabetes mellitus.
Expert opinion on drug delivery 2007;4(1):63-76.
2007: Pendergrass Merri; Bertoldo Alessandra; Bonadonna Riccardo; Nucci Gianluca; Mandarino Lawrence; Cobelli Claudio; Defronzo Ralph A
Muscle glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed individuals.
American journal of physiology. Endocrinology and metabolism 2007;292(1):E92-100.
2006: Wajcberg Estela; Thoppil Nimmi; Patel Shreya; Fernandez Marianella; Hale Daniel; DeFronzo Ralph; Cersosimo Eugenio
Comprehensive assessment of postischemic vascular reactivity in Hispanic children and adults with and without diabetes mellitus.
Pediatric diabetes 2006;7(6):329-35.
2006: Mari A; Nielsen L L; Nanayakkara N; DeFronzo R A; Ferrannini E; Halseth A
Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(12):838-44.
2006: Belfort Renata; Harrison Stephen A; Brown Kenneth; Darland Celia; Finch Joan; Hardies Jean; Balas Bogdan; Gastaldelli Amalia; Tio Fermin; Pulcini Joseph; Berria Rachele; Ma Jennie Z; Dwivedi Sunil; Havranek Russell; Fincke Chris; DeFronzo Ralph; Bannayan George A; Schenker Steven; Cusi Kenneth
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.
The New England journal of medicine 2006;355(22):2297-307.
2006: Triplitt Curtis; Glass Leonard; Miyazaki Yoshiniro; Wajcberg Estela; Gastaldelli Amalia; De Filippis Elena; Cersosimo Eugenio; DeFronzo Ralph A
Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea.
Diabetes care 2006;29(11):2371-7.
2006: Schimmack Greg; Defronzo Ralph A; Musi Nicolas
AMP-activated protein kinase: Role in metabolism and therapeutic implications.
Diabetes, obesity & metabolism 2006;8(6):591-602.
2006: Cersosimo Eugenio; DeFronzo Ralph A
Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases.
Diabetes/metabolism research and reviews 2006;22(6):423-36.
2006: Gastaldelli Amalia; Miyazaki Yoshinori; Mahankali Archana; Berria Rachele; Pettiti Maura; Buzzigoli Emma; Ferrannini Eleuterio; DeFronzo Ralph A
The effect of pioglitazone on the liver: role of adiponectin.
Diabetes care 2006;29(10):2275-81.
2006: Richardson D K; Schneider J; Fourcaudot M J; Rodriguez L M; Arya R; Dyer T D; Almasy L; Blangero J; Stern M P; Defronzo R A; Duggirala R; Jenkinson C P
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Diabetologia 2006;49(10):2317-28.
2006: Berria Rachele; Gastaldelli Amalia; Lucidi Scott; Belfort Renata; De Filippis Eleanna; Easton Caraan; Brytzki Robert; Cusi Kenneth; Jovanovic Lois; DeFronzo Ralph
Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome.
Clinical pharmacology and therapeutics 2006;80(2):105-14.
2006: Defronzo Ralph A
Is insulin resistance atherogenic? Possible mechanisms.
Atherosclerosis. Supplements 2006;7(4):11-5.
2006: Civitarese Anthony E; Ukropcova Barbara; Carling Stacy; Hulver Matthew; DeFronzo Ralph A; Mandarino Lawrence; Ravussin Eric; Smith Steve R
Role of adiponectin in human skeletal muscle bioenergetics.
Cell metabolism 2006;4(1):75-87.
2006: Abdul-Ghani Muhammad A; Williams Ken; DeFronzo Ralph; Stern Michael
Risk of progression to type 2 diabetes based on relationship between postload plasma glucose and fasting plasma glucose.
Diabetes care 2006;29(7):1613-8.
2006: Abdul-Ghani Muhammad A; Jenkinson Christopher P; Richardson Dawn K; Tripathy Devjit; DeFronzo Ralph A
Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study.
Diabetes 2006;55(5):1430-5.
2006: Abdul-Ghani Muhammad A; Tripathy Devjit; DeFronzo Ralph A
Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose.
Diabetes care 2006;29(5):1130-9.
2006: Kendall David M; Rubin Cindy J; Mohideen Pharis; Ledeine Jean-Marie; Belder Rene; Gross Jorge; Norwood Paul; O'Mahony Michael; Sall Kenneth; Sloan Greg; Roberts Anthony; Fiedorek Fred T; DeFronzo Ralph A
Improvement of glycemic control, triglycerides, and HDL cholesterol levels with muraglitazar, a dual (alpha/gamma) peroxisome proliferator-activated receptor activator, in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A double-blind, randomized, pioglitazone-comparative study.
Diabetes care 2006;29(5):1016-23.
2006: Arya Rector; Demerath Ellen; Jenkinson Christopher P; Göring Harald H H; Puppala Sobha; Farook Vidya; Fowler Sharon; Schneider Jennifer; Granato Richard; Resendez Roy G; Dyer Thomas D; Cole Shelley A; Almasy Laura; Comuzzie Anthony G; Siervogel Roger M; Bradshaw Benjamin; DeFronzo Ralph A; MacCluer Jean; Stern Michael P; Towne Bradford; Blangero John; Duggirala Ravindranath
A quantitative trait locus (QTL) on chromosome 6q influences birth weight in two independent family studies.
Human molecular genetics 2006;15(10):1569-79.
2006: Sriwijitkamol Apiradee; Ivy John L; Christ-Roberts Christine; DeFronzo Ralph A; Mandarino Lawrence J; Musi Nicolas
LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E925-32.
2006: Sriwijitkamol Apiradee; Christ-Roberts Christine; Berria Rachele; Eagan Phyllis; Pratipanawatr Thongchai; DeFronzo Ralph A; Mandarino Lawrence J; Musi Nicolas
Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes: reversal by exercise training.
Diabetes 2006;55(3):760-7.
2006: Gastaldelli Amalia; Miyazaki Yoshinori; Pettiti Maura; Santini Eleonora; Ciociaro Demetrio; Defronzo Ralph A; Ferrannini Ele
The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2006;91(3):806-12.
2005: Bajaj Mandeep; Suraamornkul Swangjit; Romanelli Anthony; Cline Gary W; Mandarino Lawrence J; Shulman Gerald I; DeFronzo Ralph A
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 2005;54(11):3148-53.
2005: Abdul-Ghani M A; DeFronzo R A
To: Godsland IF, Jeffs JA, Johnston DG (2004) loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157-1166.
Diabetologia 2005;48(10):2187-8; author reply 2189-90.
2005: DeFronzo Ralph A; Bergenstal Richard M; Cefalu William T; Pullman John; Lerman Sam; Bode Bruce W; Phillips Lawrence S;
Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial.
Diabetes care 2005;28(8):1922-8.
2005: Belfort Renata; Mandarino Lawrence; Kashyap Sangeeta; Wirfel Kelly; Pratipanawatr Thongchai; Berria Rachele; Defronzo Ralph A; Cusi Kenneth
Dose-response effect of elevated plasma free fatty acid on insulin signaling.
Diabetes 2005;54(6):1640-8.
2005: DeFronzo Ralph A; Ratner Robert E; Han Jenny; Kim Dennis D; Fineman Mark S; Baron Alain D
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes.
Diabetes care 2005;28(5):1092-100.
2005: Richardson Dawn K; Kashyap Sangeeta; Bajaj Mandeep; Cusi Kenneth; Mandarino Steven J; Finlayson Jean; DeFronzo Ralph A; Jenkinson Christopher P; Mandarino Lawrence J
Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle.
The Journal of biological chemistry 2005;280(11):10290-7.
2005: Stern Steven E; Williams Ken; Ferrannini Eleuterio; DeFronzo Ralph A; Bogardus Clifton; Stern Michael P
Identification of individuals with insulin resistance using routine clinical measurements.
Diabetes 2005;54(2):333-9.
2005: Kashyap Sangeeta R; Roman Linda J; Lamont Jennifer; Masters Bettie Sue S; Bajaj Mandeep; Suraamornkul Swangjit; Belfort Renata; Berria Rachele; Kellogg Dean L; Liu Yanjuan; DeFronzo Ralph A
Insulin resistance is associated with impaired nitric oxide synthase activity in skeletal muscle of type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism 2005;90(2):1100-5.
2005: Miranda Phillippa J; DeFronzo Ralph A; Califf Robert M; Guyton John R
Metabolic syndrome: definition, pathophysiology, and mechanisms.
American heart journal 2005;149(1):33-45.
2005: Miranda Phillippa J; DeFronzo Ralph A; Califf Robert M; Guyton John R
Metabolic syndrome: evaluation of pathological and therapeutic outcomes.
American heart journal 2005;149(1):20-32.
2005: Ferrannini Ele; Gastaldelli Amalia; Miyazaki Yoshinori; Matsuda Masafumi; Mari Andrea; DeFronzo Ralph A
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis.
The Journal of clinical endocrinology and metabolism 2005;90(1):493-500.
2004: Wajcberg Estela; Miyazaki Yoshinori; Triplitt Curtis; Cersosimo Eugenio; DeFronzo Ralph A
Dose-response effect of a single administration of oral hexyl-insulin monoconjugate 2 in healthy nondiabetic subjects.
Diabetes care 2004;27(12):2868-73.
2004: DeFronzo R A
Dysfunctional fat cells, lipotoxicity and type 2 diabetes.
International journal of clinical practice. Supplement 2004;(143):9-21.
2004: Chiquette Elaine; Ramirez Gilbert; Defronzo Ralph
A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors.
Archives of internal medicine 2004;164(19):2097-104.
2004: Bajaj Mandeep; Suraamornkul Swangjit; Kashyap Sangeeta; Cusi Kenneth; Mandarino Lawrence; DeFronzo Ralph A
Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2004;89(9):4649-55.
2004: Miyazaki Yoshinori; Mahankali Archana; Wajcberg Estela; Bajaj Mandeep; Mandarino Lawrence J; DeFronzo Ralph A
Effect of pioglitazone on circulating adipocytokine levels and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2004;89(9):4312-9.
2004: Kashyap Sangeeta R; Belfort Renata; Berria Rachele; Suraamornkul Swangjit; Pratipranawatr Thongchai; Finlayson Jean; Barrentine Andrea; Bajaj Mandeep; Mandarino Lawrence; DeFronzo Ralph; Cusi Kenneth
Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.
American journal of physiology. Endocrinology and metabolism 2004;287(3):E537-46.
2004: Gastaldelli Amalia; Miyazaki Yoshinori; Pettiti Maura; Buzzigoli Emma; Mahankali Srikanth; Ferrannini Ele; DeFronzo Ralph A
Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis.
The Journal of clinical endocrinology and metabolism 2004;89(8):3914-21.
2004: DeFronzo Ralph A
Pathogenesis of type 2 diabetes mellitus.
The Medical clinics of North America 2004;88(4):787-835, ix.
2004: Fanning Etta L; Selwyn Beatrice J; Larme Anne C; DeFronzo Ralph A
Improving efficacy of diabetes management using treatment algorithms in a mainly Hispanic population.
Diabetes care 2004;27(7):1638-46.
2004: Bajaj M; Suraamornkul S; Hardies L J; Pratipanawatr T; DeFronzo R A
Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2004;28(6):783-9.
2004: Civitarese A E; Jenkinson C P; Richardson D; Bajaj M; Cusi K; Kashyap S; Berria R; Belfort R; DeFronzo R A; Mandarino L J; Ravussin E
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.
Diabetologia 2004;47(5):816-20.
2004: Bays Harold; Mandarino Lawrence; DeFronzo Ralph A
Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.
The Journal of clinical endocrinology and metabolism 2004;89(2):463-78.
2004: Bajaj Mandeep; Suraamornkul Swangjit; Piper Paul; Hardies Lou J; Glass Leonard; Cersosimo Eugenio; Pratipanawatr Thongchai; Miyazaki Yoshinori; DeFronzo Ralph A
Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2004;89(1):200-6.
2004: Molitch Mark E; DeFronzo Ralph A; Franz Marion J; Keane William F; Mogensen Carl Erik; Parving Hans-Henrik; Steffes Michael W;
Nephropathy in diabetes.
Diabetes care 2004;27 Suppl 1():S79-83.
2004: Adams John M; Pratipanawatr Thongchai; Berria Rachele; Wang Elaine; DeFronzo Ralph A; Sullards M Cameron; Mandarino Lawrence J
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans.
Diabetes 2004;53(1):25-31.
2004: Gastaldelli A; Ferrannini E; Miyazaki Y; Matsuda M; DeFronzo R A;
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study.
Diabetologia 2004;47(1):31-9.
2003: Genuth Saul; Alberti K G M M; Bennett Peter; Buse John; Defronzo Ralph; Kahn Richard; Kitzmiller John; Knowler William C; Lebovitz Harold; Lernmark Ake; Nathan David; Palmer Jerry; Rizza Robert; Saudek Christopher; Shaw Jonathan; Steffes Michael; Stern Michael; Tuomilehto Jaako; Zimmet Paul;
Follow-up report on the diagnosis of diabetes mellitus.
Diabetes care 2003;26(11):3160-7.
2003: Kashyap Sangeeta; Belfort Renata; Gastaldelli Amalia; Pratipanawatr Thongchai; Berria Rachele; Pratipanawatr Wilailak; Bajaj Mandeep; Mandarino Lawrence; DeFronzo Ralph; Cusi Kenneth
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes.
Diabetes 2003;52(10):2461-74.
2003: Ferrannini E; Gastaldelli A; Miyazaki Y; Matsuda M; Pettiti M; Natali A; Mari A; DeFronzo R A
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance.
Diabetologia 2003;46(9):1211-9.
2003: Miyazaki Yoshinori; He Helen; Mandarino Lawrence J; DeFronzo Ralph A
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients.
Diabetes 2003;52(8):1943-50.
2003: Ferrannini Ele; Gastaldelli Amalia; Matsuda Masafumi; Miyazaki Yoshinori; Pettiti Maura; Glass Leonard; DeFronzo Ralph A
Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis.
The Journal of clinical endocrinology and metabolism 2003;88(7):3251-7.
2003: Patti Mary Elizabeth; Butte Atul J; Crunkhorn Sarah; Cusi Kenneth; Berria Rachele; Kashyap Sangeeta; Miyazaki Yoshinori; Kohane Isaac; Costello Maura; Saccone Robert; Landaker Edwin J; Goldfine Allison B; Mun Edward; DeFronzo Ralph; Finlayson Jean; Kahn C Ronald; Mandarino Lawrence J
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8466-71.
2003: Bajaj Mandeep; Suraamornkul Swangjit; Pratipanawatr Thongchai; Hardies Lou J; Pratipanawatr Wilailak; Glass Leonard; Cersosimo Eugenio; Miyazaki Yoshinori; DeFronzo Ralph A
Pioglitazone reduces hepatic fat content and augments splanchnic glucose uptake in patients with type 2 diabetes.
Diabetes 2003;52(6):1364-70.
2003: Bajaj Mandeep; Defronzo Ralph A
Metabolic and molecular basis of insulin resistance.
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2003;10(3):311-23.
2003: Appel Gerald B; Radhakrishnan Jai; Avram Morrell M; DeFronzo Ralph A; Escobar-Jimenez Fernando; Campos M M; Burgess Ellen; Hille Darcy A; Dickson Tania Z; Shahinfar Shahnaz; Brenner Barry M;
Analysis of metabolic parameters as predictors of risk in the RENAAL study.
Diabetes care 2003;26(5):1402-7.
2003: Duggirala Ravindranath; Almasy Laura; Blangero John; Jenkinson Christopher P; Arya Rector; DeFronzo Ralph A; Stern Michael P; O'Connell Peter;
Further evidence for a type 2 diabetes susceptibility locus on chromosome 11q.
Genetic epidemiology 2003;24(3):240-2.
2003: Miyazaki Y; Pipek R; Mandarino L J; DeFronzo Ralph A
Tumor necrosis factor alpha and insulin resistance in obese type 2 diabetic patients.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2003;27(1):88-94.
2003: Molitch Mark E; DeFronzo Ralph A; Franz Marion J; Keane William F; Mogensen Carl Erik; Parving Hans-Henrik;
Diabetic nephropathy.
Diabetes care 2003;26 Suppl 1():S94-8.
2002: Miyazaki Yoshinori; Glass Leonard; Triplitt Curtis; Wajcberg Estela; Mandarino Lawrence J; DeFronzo Ralph A
Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1135-43.
2002: Gastaldelli Amalia; Miyazaki Yoshinori; Pettiti Maura; Matsuda Masafumi; Mahankali Srihanth; Santini Eleonora; DeFronzo Ralph A; Ferrannini Ele
Metabolic effects of visceral fat accumulation in type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2002;87(11):5098-103.
2002: Bajaj Mandeep; Pratipanawatr Thongchai; Berria Rachele; Pratipanawatr Wilailak; Kashyap Sangeeta; Cusi Kenneth; Mandarino Lawrence; DeFronzo Ralph A
Free fatty acids reduce splanchnic and peripheral glucose uptake in patients with type 2 diabetes.
Diabetes 2002;51(10):3043-8.
2002: Matsuda Masafumi; Defronzo Ralph A; Glass Leonard; Consoli Agostino; Giordano Mauro; Bressler Peter; Delprato Stefano
Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.
Metabolism: clinical and experimental 2002;51(9):1111-9.
2002: Bajaj Mandeep; Berria Rachele; Pratipanawatr Thongchai; Kashyap Sangeeta; Pratipanawatr Wilailak; Belfort Renata; Cusi Kenneth; Mandarino Lawrence; DeFronzo Ralph A
Free fatty acid-induced peripheral insulin resistance augments splanchnic glucose uptake in healthy humans.
American journal of physiology. Endocrinology and metabolism 2002;283(2):E346-52.
2002: Miyazaki Yoshinori; Mahankali Archana; Matsuda Masafumi; Mahankali Srikanth; Hardies Jean; Cusi Kenneth; Mandarino Lawrence J; DeFronzo Ralph A
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients.
The Journal of clinical endocrinology and metabolism 2002;87(6):2784-91.
2002: Pratipanawatr Thongchai; Pratipanawatr Wilailak; Rosen Clifford; Berria Rachele; Bajaj Mandeep; Cusi Kenneth; Mandarino Lawrence; Kashyap Sangeta; Belfort Renata; DeFronzo Ralph A
Effect of IGF-I on FFA and glucose metabolism in control and type 2 diabetic subjects.
American journal of physiology. Endocrinology and metabolism 2002;282(6):E1360-8.
2002: Lee N A; Matsuda M; Bressler P; Pratipanawatr T; Glass L; Mandarino L J; DeFronzo R A
Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.
Diabetes, obesity & metabolism 2002;4(3):195-200.
2002: Miyazaki Yoshinori; Matsuda Masafumi; DeFronzo Ralph A
Dose-response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes.
Diabetes care 2002;25(3):517-23.
2002: Pratipanawatr Thongchai; Cusi Kenneth; Ngo Peter; Pratipanawatr Wilailak; Mandarino Lawrence J; DeFronzo Ralph A
Normalization of plasma glucose concentration by insulin therapy improves insulin-stimulated glycogen synthesis in type 2 diabetes.
Diabetes 2002;51(2):462-8.
2001: Miyazaki Y; Glass L; Triplitt C; Matsuda M; Cusi K; Mahankali A; Mahankali S; Mandarino L J; DeFronzo R A
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.
Diabetologia 2001;44(12):2210-9.
2001: Pratipanawatr W; Pratipanawatr T; Cusi K; Berria R; Adams J M; Jenkinson C P; Maezono K; DeFronzo R A; Mandarino L J
Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation.
Diabetes 2001;50(11):2572-8.
2001: Reasner C A; Defronzo R A
Treatment of type 2 diabetes mellitus: a rational approach based on its pathophysiology.
American family physician 2001;63(9):1687-8, 1691-2, 1694.
2001: Cusi K J; Pratipanawatr T; Koval J; Printz R; Ardehali H; Granner D K; Defronzo R A; Mandarino L J
Exercise increases hexokinase II mRNA, but not activity in obesity and type 2 diabetes.
Metabolism: clinical and experimental 2001;50(5):602-6.
2001: Iozzo P; Pratipanawatr T; Pijl H; Vogt C; Kumar V; Pipek R; Matsuda M; Mandarino L J; Cusi K J; DeFronzo R A
Physiological hyperinsulinemia impairs insulin-stimulated glycogen synthase activity and glycogen synthesis.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E712-9.
2001: Miyazaki Y; Mahankali A; Matsuda M; Glass L; Mahankali S; Ferrannini E; Cusi K; Mandarino L J; DeFronzo R A
Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone.
Diabetes care 2001;24(4):710-9.
2001: Cusi K; Cukier S; DeFronzo R A; Torres M; Puchulu F M; Redondo J C
Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.
The Journal of clinical endocrinology and metabolism 2001;86(3):1410-7.
2000: Cusi K; DeFronzo R
Recombinant human insulin-like growth factor I treatment for 1 week improves metabolic control in type 2 diabetes by ameliorating hepatic and muscle insulin resistance.
The Journal of clinical endocrinology and metabolism 2000;85(9):3077-84.
2000: Pijl H; Ohashi S; Matsuda M; Miyazaki Y; Mahankali A; Kumar V; Pipek R; Iozzo P; Lancaster J L; Cincotta A H; DeFronzo R A
Bromocriptine: a novel approach to the treatment of type 2 diabetes.
Diabetes care 2000;23(8):1154-61.
2000: Utriainen T; Lovisatti S; Mäkimattila S; Bertoldo A; Weintraub S; DeFronzo R; Cobelli C; Yki-Järvinen H
Direct measurement of the lumped constant for 2-deoxy-[1-(14)C]glucose in vivo in human skeletal muscle.
American journal of physiology. Endocrinology and metabolism 2000;279(1):E228-33.
2000: DeFronzo R A
Pharmacologic therapy for type 2 diabetes mellitus.
Annals of internal medicine 2000;133(1):73-4.
2000: Vogt C; Ardehali H; Iozzo P; Yki-Järvinen H; Koval J; Maezono K; Pendergrass M; Printz R; Granner D; DeFronzo R; Mandarino L
Regulation of hexokinase II expression in human skeletal muscle in vivo.
Metabolism: clinical and experimental 2000;49(6):814-8.
2000: Cusi K; Maezono K; Osman A; Pendergrass M; Patti M E; Pratipanawatr T; DeFronzo R A; Kahn C R; Mandarino L J
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
The Journal of clinical investigation 2000;105(3):311-20.
2000: Giordano M; Castellino P; Ohno A; Defronzo R A
Differential effects of amino acid and ketoacid on protein metabolism in humans.
Nutrition (Burbank, Los Angeles County, Calif.) 2000;16(1):15-21.
1999: Matsuda M; Liu Y; Mahankali S; Pu Y; Mahankali A; Wang J; DeFronzo R A; Fox P T; Gao J H
Altered hypothalamic function in response to glucose ingestion in obese humans.
Diabetes 1999;48(9):1801-6.
1999: Matsuda M; DeFronzo R A
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.
Diabetes care 1999;22(9):1462-70.
1999: DeFronzo R A
Pharmacologic therapy for type 2 diabetes mellitus.
Annals of internal medicine 1999;131(4):281-303.
1999: Koval J A; Maezono K; Patti M E; Pendergrass M; DeFronzo R A; Mandarino L J
Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle.
Medicine and science in sports and exercise 1999;31(7):998-1004.
1999: Matsuda M; Mandarino L; DeFronzo R A
Synergistic interaction of magnesium and vanadate on glucose metabolism in diabetic rats.
Metabolism: clinical and experimental 1999;48(6):725-31.
1999: Kudolo G B; DeFronzo R A
Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus.
Prostaglandins & other lipid mediators 1999;57(2-3):87-98.
1999: Castellino P; Luzi L; Giordano M; Defronzo R A
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
Journal of the American Society of Nephrology : JASN 1999;10(5):1050-8.
1999: Koopmans S J; Kushwaha R S; DeFronzo R A
Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.
Metabolism: clinical and experimental 1999;48(3):330-7.
1999: DeFronzo R A
Pathogenesis of type 2 diabetes: implications for metformin.
Drugs 1999;58 Suppl 1():29-30; discussion 75-82.
1998: Diamond M P; Grainger D; Diamond M C; Sherwin R S; Defronzo R A
Effects of methyltestosterone on insulin secretion and sensitivity in women.
The Journal of clinical endocrinology and metabolism 1998;83(12):4420-5.
1998: Pendergrass M; Fazioni E; Collins D; DeFronzo R A
IGF-I increases forearm blood flow without increasing forearm glucose uptake.
The American journal of physiology 1998;275(2 Pt 1):E345-50.
1998: Bonadonna R C; Saccomani M P; Del Prato S; Bonora E; DeFronzo R A; Cobelli C
Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle.
Circulation 1998;98(3):234-41.
1998: Koopmans S J; Leighton B; DeFronzo R A
Neonatal de-afferentation of capsaicin-sensitive sensory nerves increases in vivo insulin sensitivity in conscious adult rats.
Diabetologia 1998;41(7):813-20.
1998: Koopmans S J; Frolich M; Gribnau E H; Westendorp R G; DeFronzo R A
Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats.
The American journal of physiology 1998;274(6 Pt 1):E998-E1001.
1998: Koopmans S J; Mandarino L; DeFronzo R A
Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats.
The American journal of physiology 1998;274(4 Pt 1):E642-50.
1998: Pendergrass M; Koval J; Vogt C; Yki-Jarvinen H; Iozzo P; Pipek R; Ardehali H; Printz R; Granner D; DeFronzo R A; Mandarino L J
Insulin-induced hexokinase II expression is reduced in obesity and NIDDM.
Diabetes 1998;47(3):387-94.
1998: Koval J A; DeFronzo R A; O'Doherty R M; Printz R; Ardehali H; Granner D K; Mandarino L J
Regulation of hexokinase II activity and expression in human muscle by moderate exercise.
The American journal of physiology 1998;274(2 Pt 1):E304-8.
1998: Vogt C; Yki-Jarvinen H; Iozzo P; Pipek R; Pendergrass M; Koval J; Ardehali H; Printz R; Granner D; Defronzo R; Mandarino L
Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo.
The Journal of clinical endocrinology and metabolism 1998;83(1):230-4.
1997: Kudolo G B; Bressler P; DeFronzo R A
Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment.
Journal of lipid mediators and cell signalling 1997;17(2):97-113.
1997: Giordano M; Castellino P; Solini A; Canessa M L; DeFronzo R A
Na+/Li+ and Na+/H+ countertransport activity in hypertensive non-insulin-dependent diabetic patients: role of insulin resistance and antihypertensive treatment.
Metabolism: clinical and experimental 1997;46(11):1316-23.
1997: Gulli G; Rossetti L; DeFronzo R A
Hyperamylinemia is associated with hyperinsulinemia in the glucose-tolerant, insulin-resistant offspring of two Mexican-American non-insulin-dependent diabetic parents.
Metabolism: clinical and experimental 1997;46(10):1157-61.
1997: Koopmans S J; Ohman L; Haywood J R; Mandarino L J; DeFronzo R A
Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats.
Diabetes 1997;46(10):1572-8.
1997: Solini A; Bonora E; Bonadonna R; Castellino P; DeFronzo R A
Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.
The Journal of clinical endocrinology and metabolism 1997;82(8):2552-8.
1997: Del Prato S; Matsuda M; Simonson D C; Groop L C; Sheehan P; Leonetti F; Bonadonna R C; DeFronzo R A
Studies on the mass action effect of glucose in NIDDM and IDDM: evidence for glucose resistance.
Diabetologia 1997;40(6):687-97.
1997: DeFronzo R A
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosis.
The Netherlands journal of medicine 1997;50(5):191-7.
1997: Kudolo G B; Koopmans S J; Haywood J R; DeFronzo R A
Chronic hyperinsulinemia inhibits platelet-activating factor (PAF) biosynthesis in the rat kidney.
Journal of lipid mediators and cell signalling 1997;16(1):23-37.
1997: Yki-Järvinen H; Vogt C; Iozzo P; Pipek R; Daniels M C; Virkamäki A; Mäkimattila S; Mandarino L; DeFronzo R A; McClain D; Gottschalk W K
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetologia 1997;40(1):76-81.
1997: Bahl J J; Matsuda M; DeFronzo R A; Bressler R
In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase.
Biochemical pharmacology 1997;53(1):67-74.
1996: Bressler P; Bailey S R; Matsuda M; DeFronzo R A
Insulin resistance and coronary artery disease.
Diabetologia 1996;39(11):1345-50.
1996: Cusi K; Consoli A; DeFronzo R A
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1996;81(11):4059-67.
1996: DeFronzo R A; Prato S D
Insulin resistance and diabetes mellitus.
Journal of diabetes and its complications 1996;10(5):243-5.
1996: Raffel L J; Robbins D C; Norris J M; Boerwinkle E; DeFronzo R A; Elbein S C; Fujimoto W; Hanis C L; Kahn S E; Permutt M A; Chiu K C; Cruz J; Ehrmann D A; Robertson R P; Rotter J I; Buse J
The GENNID Study. A resource for mapping the genes that cause NIDDM.
Diabetes care 1996;19(8):864-72.
1996: Bonadonna R C; Del Prato S; Bonora E; Saccomani M P; Gulli G; Natali A; Frascerra S; Pecori N; Ferrannini E; Bier D; Cobelli C; DeFronzo R A
Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM.
Diabetes 1996;45(7):915-25.
1996: Reasner C A; DeFronzo R A
Diabetic nephropathy--can it be prevented?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 1996;2(3):205-8.
1996: Giordano M; Castellino P; DeFronzo R A
Differential responsiveness of protein synthesis and degradation to amino acid availability in humans.
Diabetes 1996;45(4):393-9.
1996: Yki-Järvinen H; Daniels M C; Virkamäki A; Mäkimattila S; DeFronzo R A; McClain D
Increased glutamine:fructose-6-phosphate amidotransferase activity in skeletal muscle of patients with NIDDM.
Diabetes 1996;45(3):302-7.
1996: Luzi L; Castellino P; DeFronzo R A
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
The American journal of physiology 1996;270(2 Pt 1):E273-81.
1996: Saccomani M P; Bonadonna R C; Bier D M; DeFronzo R A; Cobelli C
A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study.
The American journal of physiology 1996;270(1 Pt 1):E170-85.
1996: Giordano M; Sanders L R; Castellino P; Canessa M L; DeFronzo R A
Effect of alpha-adrenergic blockers, ACE inhibitors, and calcium channel antagonists on renal function in hypertensive non-insulin-dependent diabetic patients.
Nephron 1996;72(3):447-53.
1995: Bonora E; Micciolo R; Ghiatas A A; Lancaster J L; Alyassin A; Muggeo M; DeFronzo R A
Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements?
Metabolism: clinical and experimental 1995;44(12):1617-25.
1995: Barzilai N; Groop P H; Groop L; DeFronzo R A
A novel mechanism of glipizide sulfonylurea action: decreased metabolic clearance rate of insulin.
Acta diabetologica 1995;32(4):273-8.
1995: Mandarino L J; Printz R L; Cusi K A; Kinchington P; O'Doherty R M; Osawa H; Sewell C; Consoli A; Granner D K; DeFronzo R A
Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle.
The American journal of physiology 1995;269(4 Pt 1):E701-8.
1995: Diamond M P; Thornton K; Connolly-Diamond M; Sherwin R S; DeFronzo R A
Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance.
Journal of the Society for Gynecologic Investigation 1995;2(5):708-15.
1995: DeFronzo R A; Goodman A M
Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. The Multicenter Metformin Study Group.
The New England journal of medicine 1995;333(9):541-9.
1995: Thornton K L; DeFronzo R A; Sherwin R S; Diamond M P
Micronized estradiol and progesterone: effects on carbohydrate metabolism in reproductive-age women.
Journal of the Society for Gynecologic Investigation 1995;2(4):643-52.
1995: Saccomani M P; Bonadonna R C; Caveggion E; DeFronzo R A; Cobelli C
Bicarbonate kinetics in humans: identification and validation of a three-compartment model.
The American journal of physiology 1995;269(1 Pt 1):E183-92.
1995: Giordano M; Matsuda M; Sanders L; Canessa M L; DeFronzo R A
Effects of angiotensin-converting enzyme inhibitors, Ca2+ channel antagonists, and alpha-adrenergic blockers on glucose and lipid metabolism in NIDDM patients with hypertension.
Diabetes 1995;44(6):665-71.
1995: Giordano M; Castellino P; Carroll C A; DeFronzo R A
Comparison of the effects of human recombinant insulin-like growth factor I and insulin on plasma amino acid concentrations and leucine kinetics in humans.
Diabetologia 1995;38(6):732-8.
1995: Del Prato S; Riccio A; Vigili de Kreutzenberg S; Dorella M; Tiengo A; DeFronzo R A
Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake.
The American journal of physiology 1995;268(6 Pt 1):E1089-95.
1995: Bonora E; Gulli G; Bonadonna R; Del Prato S; Solini A; DeFronzo R A
Insulin sensitivity is not impaired in Mexican-American women without a family history of diabetes.
Diabetes care 1995;18(6):825-33.
1995: Shank M L; Del Prato S; DeFronzo R A
Bedtime insulin/daytime glipizide. Effective therapy for sulfonylurea failures in NIDDM.
Diabetes 1995;44(2):165-72.
1995: Giordano M; DeFronzo R A
Acute effect of human recombinant insulin-like growth factor I on renal function in humans.
Nephron 1995;71(1):10-5.
1994: Giordano M; Castellino P; McConnell E L; DeFronzo R A
Effect of amino acid infusion on renal hemodynamics in humans: a dose-response study.
The American journal of physiology 1994;267(5 Pt 2):F703-8.
1994: Mari A; Wahren J; DeFronzo R A; Ferrannini E
Glucose absorption and production following oral glucose: comparison of compartmental and arteriovenous-difference methods.
Metabolism: clinical and experimental 1994;43(11):1419-25.
1994: DeFronzo R A; Reasner C
The Diabetes Control and Complications Trial Study: implications for the diabetic foot.
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons 1994;33(6):551-6.
1994: Reasner C A; DeFronzo R
Diabetic nephropathy: pathogenetic basis for treatment.
Contemporary internal medicine 1994;6(10):30-2, 35-40.
1994: Del Prato S; Leonetti F; Simonson D C; Sheehan P; Matsuda M; DeFronzo R A
Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man.
Diabetologia 1994;37(10):1025-35.
1994: Petrides A S; Luzi L; DeFronzo R A
Time-dependent regulation by insulin of leucine metabolism in young healthy adults.
The American journal of physiology 1994;267(3 Pt 1):E361-8.
1994: Bonadonna R C; Groop L C; Simonson D C; DeFronzo R A
Free fatty acid and glucose metabolism in human aging: evidence for operation of the Randle cycle.
The American journal of physiology 1994;266(3 Pt 1):E501-9.
1994: Barrett E J; Bevilacqua S; DeFronzo R A; Ferrannini E
Glycogen turnover during refeeding in the postabsorptive dog: implications for the estimation of glycogen formation using tracer methods.
Metabolism: clinical and experimental 1994;43(3):285-92.
1994: Castellino P; Tuttle K R; DeFronzo R A
Diabetic nephropathy.
Current therapy in endocrinology and metabolism 1994;5():426-36.
1993: Bonadonna R C; del Prato S; Bonora E; Gulli G; Solini A; DeFronzo R A
Effects of physiological hyperinsulinemia on the intracellular metabolic partition of plasma glucose.
The American journal of physiology 1993;265(6 Pt 1):E943-53.
1993: Bonadonna R C; Del Prato S; Saccomani M P; Bonora E; Gulli G; Ferrannini E; Bier D; Cobelli C; DeFronzo R A
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.
The Journal of clinical investigation 1993;92(1):486-94.
1993: Diamond M P; Jacob R; Connolly-Diamond M; DeFronzo R A
Glucose metabolism during the menstrual cycle. Assessment with the euglycemic, hyperinsulinemic clamp.
The Journal of reproductive medicine 1993;38(6):417-21.
1993: Bonora E; Bonadonna R C; Del Prato S; Gulli G; Solini A; Matsuda M; DeFronzo R A
In vivo glucose metabolism in obese and type II diabetic subjects with or without hypertension.
Diabetes 1993;42(5):764-72.
1993: Saloranta C; Koivisto V; Widén E; Falholt K; DeFronzo R A; Härkönen M; Groop L
Contribution of muscle and liver to glucose-fatty acid cycle in humans.
The American journal of physiology 1993;264(4 Pt 1):E599-605.
1993: Bonadonna R C; Saccomani M P; Cobelli C; DeFronzo R A
Effect of insulin on system A amino acid transport in human skeletal muscle.
The Journal of clinical investigation 1993;91(2):514-21.
1993: Del Prato S; Bonadonna R C; Bonora E; Gulli G; Solini A; Shank M; DeFronzo R A
Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.
The Journal of clinical investigation 1993;91(2):484-94.
1993: Bonadonna R C; Saccomani M P; Seely L; Zych K S; Ferrannini E; Cobelli C; DeFronzo R A
Glucose transport in human skeletal muscle. The in vivo response to insulin.
Diabetes 1993;42(1):191-8.
1992: Grainger D; Thornton K; Rossi G; Connoly-Diamond M; DeFronzo R; Sherwin R; Diamond M P
Influence of basal androgen levels in euandrogenic women on glucose homeostasis.
Fertility and sterility 1992;58(6):1113-8.
1992: Gulli G; Ferrannini E; Stern M; Haffner S; DeFronzo R A
The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents.
Diabetes 1992;41(12):1575-86.
1992: Groop L C; Bonadonna R C; Simonson D C; Petrides A S; Shank M; DeFronzo R A
Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity.
The American journal of physiology 1992;263(1 Pt 1):E79-84.
1992: DeFronzo R A
Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview.
Diabetologia 1992;35(4):389-97.
1992: DeFronzo R A; Bonadonna R C; Ferrannini E
Pathogenesis of NIDDM. A balanced overview.
Diabetes care 1992;15(3):318-68.
1992: Castellino P; Solini A; Luzi L; Barr J G; Smith D J; Petrides A; Giordano M; Carroll C; DeFronzo R A
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
The American journal of physiology 1992;262(2 Pt 2):F168-76.
1992: Frontoni S; Ohman L; Haywood J R; DeFronzo R A; Rossetti L
In vivo insulin action in genetic models of hypertension.
The American journal of physiology 1992;262(2 Pt 1):E191-6.
1992: Mak R H; DeFronzo R A
Glucose and insulin metabolism in uremia.
Nephron 1992;61(4):377-82.
1992: Petrides A S; Strohmeyer G; DeFronzo R A
Insulin resistance in liver disease and portal hypertension.
Progress in liver diseases 1992;10():311-28.
1992: DeFronzo R A
Insulin resistance, hyperinsulinemia, and coronary artery disease: a complex metabolic web.
Journal of cardiovascular pharmacology 1992;20 Suppl 11():S1-16.
1991: DeFronzo R A; Barzilai N; Simonson D C
Mechanism of metformin action in obese and lean noninsulin-dependent diabetic subjects.
The Journal of clinical endocrinology and metabolism 1991;73(6):1294-301.
1991: Petrides A S; Luzi L; Reuben A; Riely C; DeFronzo R A
Effect of insulin and plasma amino acid concentration on leucine metabolism in cirrhosis.
Hepatology (Baltimore, Md.) 1991;14(3):432-41.
1991: Groop L C; Barzilai N; Ratheiser K; Luzi L; Wåhlin-Boll E; Melander A; DeFronzo R A
Dose-dependent effects of glyburide on insulin secretion and glucose uptake in humans.
Diabetes care 1991;14(8):724-7.
1991: Petrides A S; Groop L C; Riely C A; DeFronzo R A
Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis.
The Journal of clinical investigation 1991;88(2):561-70.
1991: Tuttle K R; Bruton J L; Perusek M C; Lancaster J L; Kopp D T; DeFronzo R A
Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus.
The New England journal of medicine 1991;324(23):1626-32.
1991: Shulman G I; DeFronzo R A; Rossetti L
Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion.
The American journal of physiology 1991;260(5 Pt 1):E731-5.
1991: Lancaster J L; Ghiatas A A; Alyassin A; Kilcoyne R F; Bonora E; DeFronzo R A
Measurement of abdominal fat with T1-weighted MR images.
Journal of magnetic resonance imaging : JMRI 1991;1(3):363-9.
1991: Rossetti L; Frontoni S; Dimarchi R; DeFronzo R A; Giaccari A
Metabolic effects of IGF-I in diabetic rats.
Diabetes 1991;40(4):444-8.
1991: Diamond M P; Grainger D A; Laudano A J; Starick-Zych K; DeFronzo R A
Effect of acute physiological elevations of insulin on circulating androgen levels in nonobese women.
The Journal of clinical endocrinology and metabolism 1991;72(4):883-7.
1991: DeFronzo R A; Ferrannini E
Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.
Diabetes care 1991;14(3):173-94.
1991: Tuttle K R; DeFronzo R A; Stein J H
Treatment of diabetic nephropathy: a rational approach based on its pathophysiology.
Seminars in nephrology 1991;11(2):220-35.
1991: Kahn B B; Shulman G I; DeFronzo R A; Cushman S W; Rossetti L
Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.
The Journal of clinical investigation 1991;87(2):561-70.
1991: Groop L C; Saloranta C; Shank M; Bonadonna R C; Ferrannini E; DeFronzo R A
The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1991;72(1):96-107.
1991: Groop L C; Bonadonna R C; Shank M; Petrides A S; DeFronzo R A
Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man.
The Journal of clinical investigation 1991;87(1):83-9.
1991: Petrides A S; Riely C A; DeFronzo R A
Insulin resistance in noncirrhotic idiopathic portal hypertension.
Gastroenterology 1991;100(1):245-51.
1991: Groop L C; Ratheiser K; Luzi L; Melander A; Simonson D C; Petrides A; Bonadonna R C; Widén E; DeFronzo R A
Effect of sulphonylurea on glucose-stimulated insulin secretion in healthy and non-insulin dependent diabetic subjects: a dose-response study.
Acta diabetologica 1991;28(2):162-8.
1990: Bonadonna R C; Groop L C; Zych K; Shank M; DeFronzo R A
Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans.
The American journal of physiology 1990;259(5 Pt 1):E736-50.
1990: Ferrannini E; Katz L D; Glickman M G; Defronzo R A
Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man.
Clinical physiology (Oxford, England) 1990;10(6):527-38.
1990: Castellino P; DeFronzo R A
Glucose metabolism and the kidney.
Seminars in nephrology 1990;10(5):458-63.
1990: Groop L C; Bonadonna R; DelPrato S; Ratheiser K; DeFronzo R A
Effect of prolonged overnight fasting on energy metabolism in non-insulin-dependent diabetic and non-diabetic subjects.
Acta endocrinologica 1990;123(1):30-6.
1990: Rossetti L; Giaccari A; DeFronzo R A
Glucose toxicity.
Diabetes care 1990;13(6):610-30.
1990: Castellino P; Shohat J; DeFronzo R A
Hyperfiltration and diabetic nephropathy: is it the beginning? Or is it the end?
Seminars in nephrology 1990;10(3):228-41.
1990: Tuttle K R; Stein J H; DeFronzo R A
The natural history of diabetic nephropathy.
Seminars in nephrology 1990;10(3):184-93.
1990: Bonadonna R C; Groop L; Kraemer N; Ferrannini E; Del Prato S; DeFronzo R A
Obesity and insulin resistance in humans: a dose-response study.
Metabolism: clinical and experimental 1990;39(5):452-9.
1990: Del Prato S; DeFronzo R A; Castellino P; Wahren J; Alvestrand A
Regulation of amino acid metabolism by epinephrine.
The American journal of physiology 1990;258(5 Pt 1):E878-87.
1990: Castellino P; Levin R; Shohat J; DeFronzo R A
Effect of specific amino acid groups on renal hemodynamics in humans.
The American journal of physiology 1990;258(4 Pt 2):F992-7.
1990: Kurtzman N A; Gonzalez J; DeFronzo R; Giebisch G
A patient with hyperkalemia and metabolic acidosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1990;15(4):333-56.
1990: Rossetti L; DeFronzo R A; Gherzi R; Stein P; Andraghetti G; Falzetti G; Shulman G I; Klein-Robbenhaar E; Cordera R
Effect of metformin treatment on insulin action in diabetic rats: in vivo and in vitro correlations.
Metabolism: clinical and experimental 1990;39(4):425-35.
1990: Cordera R; Andraghetti G; DeFronzo R A; Rossetti L
Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats.
Endocrinology 1990;126(4):2177-83.
1990: Groop L; Mäkipernaa A; Stenman S; DeFronzo R A; Teppo A M
Urinary excretion of kappa light chains in patients with diabetes mellitus.
Kidney international 1990;37(4):1120-5.
1990: Koivisto V A; Yki-Järvinen H; Puhakainen I; Virkamäki A; Kolaczynski J; DeFronzo R
No evidence for isotope discrimination of tritiated glucose tracers in measurements of glucose turnover rates in man.
Diabetologia 1990;33(3):168-73.
1990: Simonson D C; DeFronzo R A
Indirect calorimetry: methodological and interpretative problems.
The American journal of physiology 1990;258(3 Pt 1):E399-412.
1990: Castellino P; Bia M J; DeFronzo R A
Adrenergic modulation of potassium metabolism in uremia.
Kidney international 1990;37(2):793-8.
1990: Shulman G I; Rothman D L; Jue T; Stein P; DeFronzo R A; Shulman R G
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
The New England journal of medicine 1990;322(4):223-8.
1990: Luzi L; Castellino P; Simonson D C; Petrides A S; DeFronzo R A
Leucine metabolism in IDDM. Role of insulin and substrate availability.
Diabetes 1990;39(1):38-48.
1990: Castellino P; Luzi L; Del Prato S; DeFronzo R A
Dissociation of the effects of epinephrine and insulin on glucose and protein metabolism.
The American journal of physiology 1990;258(1 Pt 1):E117-25.
1989: Petrides A S; DeFronzo R A
Glucose metabolism in cirrhosis: a review with some perspectives for the future.
Diabetes/metabolism reviews 1989;5(8):691-709.
1989: Cobelli C; Saccomani M P; Ferrannini E; Defronzo R A; Gelfand R; Bonadonna R
A compartmental model to quantitate in vivo glucose transport in the human forearm.
The American journal of physiology 1989;257(6 Pt 1):E943-58.
1989: Luzi L; DeFronzo R A
Effect of loss of first-phase insulin secretion on hepatic glucose production and tissue glucose disposal in humans.
The American journal of physiology 1989;257(2 Pt 1):E241-6.
1989: Rossetti L; Rothman D L; DeFronzo R A; Shulman G I
Effect of dietary protein on in vivo insulin action and liver glycogen repletion.
The American journal of physiology 1989;257(2 Pt 1):E212-9.
1989: Diamond M P; Simonson D C; DeFronzo R A
Menstrual cyclicity has a profound effect on glucose homeostasis.
Fertility and sterility 1989;52(2):204-8.
1989: Bonadonna R C; Zych K; Boni C; Ferrannini E; DeFronzo R A
Time dependence of the interaction between lipid and glucose in humans.
The American journal of physiology 1989;257(1 Pt 1):E49-56.
1989: Groop L C; Bonadonna R C; DelPrato S; Ratheiser K; Zyck K; Ferrannini E; DeFronzo R A
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.
The Journal of clinical investigation 1989;84(1):205-13.
1989: Groop L C; Luzi L; DeFronzo R A; Melander A
Hyperglycaemia and absorption of sulphonylurea drugs.
Lancet 1989;2(8655):129-30.
1989: Jue T; Rothman D L; Shulman G I; Tavitian B A; DeFronzo R A; Shulman R G
Direct observation of glycogen synthesis in human muscle with 13C NMR.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4489-91.
1989: Stein P P; Hunt W A; Johnson C M; DeFronzo R A; Smith J D
Insulin resistance in uremia: an in vivo and in vitro study.
Metabolism: clinical and experimental 1989;38(6):562-7.
1989: DeFronzo R A; Ferrannini E; Simonson D C
Fasting hyperglycemia in non-insulin-dependent diabetes mellitus: contributions of excessive hepatic glucose production and impaired tissue glucose uptake.
Metabolism: clinical and experimental 1989;38(4):387-95.
1989: Petrides A S; DeFronzo R A
Glucose and insulin metabolism in cirrhosis.
Journal of hepatology 1989;8(1):107-14.
1988: Golay A; Felber J P; Jequier E; DeFronzo R A; Ferrannini E
Metabolic basis of obesity and noninsulin-dependent diabetes mellitus.
Diabetes/metabolism reviews 1988;4(8):727-47.
1988: Luzi L; Barrett E J; Groop L C; Ferrannini E; DeFronzo R A
Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis.
Diabetes 1988;37(11):1470-7.
1988: Gelfand R A; Glickman M G; Castellino P; Louard R J; DeFronzo R A
Measurement of L-[1-14C]leucine kinetics in splanchnic and leg tissues in humans. Effect of amino acid infusion.
Diabetes 1988;37(10):1365-72.
1988: Castellino P; Giordano C; Perna A; DeFronzo R A
Effects of plasma amino acid and hormone levels on renal hemodynamics in humans.
The American journal of physiology 1988;255(3 Pt 2):F444-9.
1988: Golay A; DeFronzo R A; Ferrannini E; Simonson D C; Thorin D; Acheson K; Thiébaud D; Curchod B; Jéquier E; Felber J P
Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients.
Diabetologia 1988;31(8):585-91.
1988: Golay A; Defronzo R A; Thorin D; Jequier E; Felber J P
Glucose disposal in obese non-diabetic and diabetic type II patients. A study by indirect calorimetry and euglycemic insulin clamp.
Diabète & métabolisme 1988;14(4):443-51.
1988: DeFronzo R A
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.
Diabetes 1988;37(6):667-87.
1988: Ferrannini E; DeFronzo R A; Gusberg R; Tepler J; Jacob R; Aaron M; Smith D; Barrett E J
Splanchnic amino acid and glucose metabolism during amino acid infusion in dogs.
Diabetes 1988;37(2):237-45.
1988: Simonson D C; Tappy L; Jequier E; Felber J P; DeFronzo R A
Normalization of carbohydrate-induced thermogenesis by fructose in insulin-resistant states.
The American journal of physiology 1988;254(2 Pt 1):E201-7.
1988: DeFronzo R A
Obesity is associated with impaired insulin-mediated potassium uptake.
Metabolism: clinical and experimental 1988;37(2):105-8.
1988: Alvestrand A; Defronzo R A; Smith D; Wahren J
Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia.
Clinical science (London, England : 1979) 1988;74(2):155-63.
1988: Ferrannini E; Simonson D C; Katz L D; Reichard G; Bevilacqua S; Barrett E J; Olsson M; DeFronzo R A
The disposal of an oral glucose load in patients with non-insulin-dependent diabetes.
Metabolism: clinical and experimental 1988;37(1):79-85.
1988: Felber J P; Golay A; Jéquier E; Curchod B; Temler E; DeFronzo R A; Ferrannini E
The metabolic consequences of long-term human obesity.
International journal of obesity 1988;12(5):377-89.
1988: Castellino P; DeFronzo R A
Effect of plasma amino acid and hormone concentrations on renal plasma flow and glomerular filtration rate.
Blood purification 1988;6(4):240-9.
1987: Castellino P; Bia M; DeFronzo R A
Metabolic response to exercise in dialysis patients.
Kidney international 1987;32(6):877-83.
1987: Smith D; Rossetti L; Ferrannini E; Johnson C M; Cobelli C; Toffolo G; Katz L D; DeFronzo R A
In vivo glucose metabolism in the awake rat: tracer and insulin clamp studies.
Metabolism: clinical and experimental 1987;36(12):1167-74.
1987: Castellino P; Luzi L; Simonson D C; Haymond M; DeFronzo R A
Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis.
The Journal of clinical investigation 1987;80(6):1784-93.
1987: DeFronzo R A; Sherwin R S; Kraemer N
Effect of physical training on insulin action in obesity.
Diabetes 1987;36(12):1379-85.
1987: DeFronzo R A
Use of the splanchnic/hepatic balance technique in the study of glucose metabolism.
Baillière's clinical endocrinology and metabolism 1987;1(4):837-62.
1987: Felber J P; Ferrannini E; Golay A; Meyer H U; Theibaud D; Curchod B; Maeder E; Jequier E; DeFronzo R A
Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes.
Diabetes 1987;36(11):1341-50.
1987: Groop L; Luzi L; Melander A; Groop P H; Ratheiser K; Simonson D C; DeFronzo R A
Different effects of glyburide and glipizide on insulin secretion and hepatic glucose production in normal and NIDDM subjects.
Diabetes 1987;36(11):1320-8.
1987: Castellino P; Hunt W; DeFronzo R A
Regulation of renal hemodynamics by plasma amino acid and hormone concentrations.
Kidney international. Supplement 1987;22():S15-20.
1987: Rossetti L; Shulman G I; Zawalich W; DeFronzo R A
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
The Journal of clinical investigation 1987;80(4):1037-44.
1987: Rossetti L; Smith D; Shulman G I; Papachristou D; DeFronzo R A
Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats.
The Journal of clinical investigation 1987;79(5):1510-5.
1987: Amiel S A; Simonson D C; Tamborlane W V; DeFronzo R A; Sherwin R S
Rate of glucose fall does not affect counterregulatory hormone responses to hypoglycemia in normal and diabetic humans.
Diabetes 1987;36(4):518-22.
1987: DeFronzo R A; Ferrannini E
Regulation of hepatic glucose metabolism in humans.
Diabetes/metabolism reviews 1987;3(2):415-59.
1987: Del Prato S; Castellino P; Simonson D C; DeFronzo R A
Hyperglucagonemia and insulin-mediated glucose metabolism.
The Journal of clinical investigation 1987;79(2):547-56.
1987: Simonson D C; Delprato S; Castellino P; Groop L; DeFronzo R A
Effect of glyburide on glycemic control, insulin requirement, and glucose metabolism in insulin-treated diabetic patients.
Diabetes 1987;36(2):136-46.
1987: Rossetti L; Klein-Robbenhaar G; Giebisch G; Smith D; DeFronzo R
Effect of insulin on renal potassium metabolism.
The American journal of physiology 1987;252(1 Pt 2):F60-4.
1987: Castellino P; Simonson D C; DeFronzo R A
Adrenergic modulation of potassium metabolism during exercise in normal and diabetic humans.
The American journal of physiology 1987;252(1 Pt 1):E68-76.
1987: Sager P T; DeFronzo R A
Dopaminergic regulation of extrarenal potassium metabolism.
Mineral and electrolyte metabolism 1987;13(6):385-92.
1986: DeFronzo R
Conversation with ... Ralph DeFronzo, MD: dealing with the older diabetic. Interview by Richard L. Peck.
Geriatrics 1986;41(12):89-92.
1986: Desir G; Bratusch-Marrain P; DeFronzo R A
Effect of hyperketonemia on renal ammonia excretion in man.
Metabolism: clinical and experimental 1986;35(8):736-43.
1986: Barrett E J; Gusberg R; Ferrannini E; Tepler J; Felig P; Jacob R; Smith D; DeFronzo R A
Amino acid and glucose metabolism in the postabsorptive state and following amino acid ingestion in the dog.
Metabolism: clinical and experimental 1986;35(8):709-17.
1986: Castellino P; Coda B; DeFronzo R A
Effect of amino acid infusion on renal hemodynamics in humans.
The American journal of physiology 1986;251(1 Pt 2):F132-40.
1986: Tappy L; Randin J P; Felber J P; Chiolero R; Simonson D C; Jequier E; DeFronzo R A
Comparison of thermogenic effect of fructose and glucose in normal humans.
The American journal of physiology 1986;250(6 Pt 1):E718-24.
1986: Ferrannini E; Barrett E J; Bevilacqua S; Jacob R; Walesky M; Sherwin R S; DeFronzo R A
Effect of free fatty acids on blood amino acid levels in human.
The American journal of physiology 1986;250(6 Pt 1):E686-94.
1986: Thorin D; Golay A; Simonson D C; Jéquier E; Felber J P; DeFronzo R A
The effect of selective beta adrenergic blockade on glucose-induced thermogenesis in man.
Metabolism: clinical and experimental 1986;35(6):524-8.
1986: Gelfand R A; Glickman M G; Jacob R; Sherwin R S; DeFronzo R A
Removal of infused amino acids by splanchnic and leg tissues in humans.
The American journal of physiology 1986;250(4 Pt 1):E407-13.
1986: Bratusch-Marrain P R; DeFronzo R A
Failure of hyperketonemia to alter basal and insulin-mediated glucose metabolism in man.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1986;18(3):185-9.
1986: Koivisto V A; Yki-Järvinen H; DeFronzo R A
Physical training and insulin sensitivity.
Diabetes/metabolism reviews 1986;1(4):445-81.
1985: DeFronzo R A; Smith J D
Is glucose intolerance harmful for the uremic patient?
Kidney international. Supplement 1985;17():S88-97.
1985: Shulman G I; Rothman D L; Smith D; Johnson C M; Blair J B; Shulman R G; DeFronzo R A
Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy.
The Journal of clinical investigation 1985;76(3):1229-36.
1985: Rodin J; Wack J; Ferrannini E; DeFronzo R A
Effect of insulin and glucose on feeding behavior.
Metabolism: clinical and experimental 1985;34(9):826-31.
1985: Bevilacqua S; Barrett E J; Smith D; Simonson D C; Olsson M; Bratusch-Marrain P; Ferrannini E; DeFronzo R A
Hepatic and peripheral insulin resistance following streptozotocin-induced insulin deficiency in the dog.
Metabolism: clinical and experimental 1985;34(9):817-25.
1985: Simonson D C; Tamborlane W V; Sherwin R S; Smith J D; DeFronzo R A
Improved insulin sensitivity in patients with type I diabetes mellitus after CSII.
Diabetes 1985;34 Suppl 3():80-6.
1985: Simonson D C; Tamborlane W V; DeFronzo R A; Sherwin R S
Intensive insulin therapy reduces counterregulatory hormone responses to hypoglycemia in patients with type I diabetes.
Annals of internal medicine 1985;103(2):184-90.
1985: Ferrannini E; Smith J D; Cobelli C; Toffolo G; Pilo A; DeFronzo R A
Effect of insulin on the distribution and disposition of glucose in man.
The Journal of clinical investigation 1985;76(1):357-64.
1985: DeFronzo R A; Gunnarsson R; Björkman O; Olsson M; Wahren J
Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.
The Journal of clinical investigation 1985;76(1):149-55.
1985: Ferrannini E; Bjorkman O; Reichard G A; Pilo A; Olsson M; Wahren J; DeFronzo R A
The disposal of an oral glucose load in healthy subjects. A quantitative study.
Diabetes 1985;34(6):580-8.
1985: Barrett E J; Ferrannini E; Gusberg R; Bevilacqua S; DeFronzo R A
Hepatic and extrahepatic splanchnic glucose metabolism in the postabsorptive and glucose fed dog.
Metabolism: clinical and experimental 1985;34(5):410-20.
1985: Stanton B; Giebisch G; Klein-Robbenhaar G; Wade J; DeFronzo R A
Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney.
The Journal of clinical investigation 1985;75(4):1317-26.
1985: Stanton B; Janzen A; Klein-Robbenhaar G; DeFronzo R; Giebisch G; Wade J
Ultrastructure of rat initial collecting tubule. Effect of adrenal corticosteroid treatment.
The Journal of clinical investigation 1985;75(4):1327-34.
1985: Akmal M; Massry S G; Goldstein D A; Fanti P; Weisz A; DeFronzo R A
Role of parathyroid hormone in the glucose intolerance of chronic renal failure.
The Journal of clinical investigation 1985;75(3):1037-44.
1985: Koivisto V A; Härkönen M; Karonen S L; Groop P H; Elovainio R; Ferrannini E; Sacca L; Defronzo R A
Glycogen depletion during prolonged exercise: influence of glucose, fructose, or placebo.
Journal of applied physiology (Bethesda, Md. : 1985) 1985;58(3):731-7.
1984: Yki-Järvinen H; DeFronzo R A; Koivisto V A
Normalization of insulin sensitivity in type I diabetic subjects by physical training during insulin pump therapy.
Diabetes care 1984;7(6):520-7.
1984: Simonson D C; Ferrannini E; Bevilacqua S; Smith D; Barrett E; Carlson R; DeFronzo R A
Mechanism of improvement in glucose metabolism after chronic glyburide therapy.
Diabetes 1984;33(9):838-45.
1984: Katz L D; D'Avella J; DeFronzo R A
Effect of epinephrine on renal potassium excretion in the isolated perfused rat kidney.
The American journal of physiology 1984;247(2 Pt 2):F331-8.
1984: Simonson D C; Koivisto V; Sherwin R S; Ferrannini E; Hendler R; Juhlin-Dannfelt A; DeFronzo R A
Adrenergic blockade alters glucose kinetics during exercise in insulin-dependent diabetics.
The Journal of clinical investigation 1984;73(6):1648-58.
1984: DeFronzo R A; Simonson D
Diabetes in the elderly: not just "normal aging".
Geriatrics 1984;39(5):16, 19.
1984: DeFronzo R A; Simonson D C
Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals.
Diabetes care 1984;7 Suppl 1():72-80.
1984: Barrett E J; DeFronzo R A
Diabetic ketoacidosis: diagnosis and treatment.
Hospital practice (Office ed.) 1984;19(4):89-95, 99-104.
1984: DeFronzo R A; Thorin D; Felber J P; Simonson D C; Thiebaud D; Jequier E; Golay A
Effect of beta and alpha adrenergic blockade on glucose-induced thermogenesis in man.
The Journal of clinical investigation 1984;73(3):633-9.
1984: Alvestrand A; Wahren J; Smith D; DeFronzo R A
Insulin-mediated potassium uptake is normal in uremic and healthy subjects.
The American journal of physiology 1984;246(2 Pt 1):E174-80.
1984: Gelfand R A; DeFronzo R A
Hypoglycemic counterregulation in normal and diabetic man.
Annals of clinical research 1984;16(2):84-93.
1983: DeFronzo R A; Smith D; Alvestrand A
Insulin action in uremia.
Kidney international. Supplement 1983;16():S102-14.
1983: Bia M J; Tyler K; DeFronzo R
The effect of dexamethasone on renal potassium excretion and acute potassium tolerance.
Endocrinology 1983;113(5):1690-6.
1983: Bratusch-Marrain P R; DeFronzo R A
Impairment of insulin-mediated glucose metabolism by hyperosmolality in man.
Diabetes 1983;32(11):1028-34.
1983: Ferrannini E; Barrett E J; Bevilacqua S; DeFronzo R A
Effect of fatty acids on glucose production and utilization in man.
The Journal of clinical investigation 1983;72(5):1737-47.
1983: Felber J P; Thiébaud D; Maeder E; Jéquier E; Hendler R; DeFronzo R A
Effect of somatostatin-induced insulinopenia on glucose oxidation in man.
Diabetologia 1983;25(4):325-30.
1983: DeFronzo R A; Stanton B; Klein-Robbenhaar G; Giebisch G
Inhibitory effect of epinephrine on renal potassium secretion: a micropuncture study.
The American journal of physiology 1983;245(3):F303-11.
1983: Schutz Y; Thiébaud D; Acheson K J; Felber J P; Defronzo R A; Jéquier E
Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men.
Clinical nutrition (Edinburgh, Scotland) 1983;2(2):93-6.
1983: Simonson D C; DeFronzo R A
Glucagon physiology and aging: evidence for enhanced hepatic sensitivity.
Diabetologia 1983;25(1):1-7.
1983: Katz L D; Glickman M G; Rapoport S; Ferrannini E; DeFronzo R A
Splanchnic and peripheral disposal of oral glucose in man.
Diabetes 1983;32(7):675-9.
1983: Ferrannini E; Wahren J; Faber O K; Felig P; Binder C; DeFronzo R A
Splanchnic and renal metabolism of insulin in human subjects: a dose-response study.
The American journal of physiology 1983;244(6):E517-27.
1983: Thiebaud D; Acheson K; Schutz Y; Felber J P; Golay A; Defronzo R A; Jéquier E
Stimulation of thermogenesis in men after combined glucose-long-chain triglyceride infusion.
The American journal of clinical nutrition 1983;37(4):603-11.
1983: Thiebaud D; Schutz Y; Acheson K; Jacot E; DeFronzo R A; Felber J P; Jequier E
Energy cost of glucose storage in human subjects during glucose-insulin infusions.
The American journal of physiology 1983;244(3):E216-21.
1983: DeFronzo R A; Ferrannini E; Koivisto V
New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus.
The American journal of medicine 1983;74(1A):52-81.
1983: DeFronzo R A; Ferrannini E; Hendler R; Felig P; Wahren J
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man.
Diabetes 1983;32(1):35-45.
1982: Wallberg-Henriksson H; Gunnarsson R; Henriksson J; DeFronzo R; Felig P; Ostman J; Wahren J
Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training.
Diabetes 1982;31(12):1044-50.
1982: Thiebaud D; Jacot E; DeFronzo R A; Maeder E; Jequier E; Felber J P
The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man.
Diabetes 1982;31(11):957-63.
1982: Thiébaud D; DeFronzo R A; Jacot E; Golay A; Acheson K; Maeder E; Jéquier E; Felber J P
Effect of long chain triglyceride infusion on glucose metabolism in man.
Metabolism: clinical and experimental 1982;31(11):1128-36.
1982: Bratusch-Marrain P R; Smith D; DeFronzo R A
The effect of growth hormone on glucose metabolism and insulin secretion in man.
The Journal of clinical endocrinology and metabolism 1982;55(5):973-82.
1982: Barrett E J; DeFronzo R A; Bevilacqua S; Ferrannini E
Insulin resistance in diabetic ketoacidosis.
Diabetes 1982;31(10):923-8.
1982: DeFronzo R A; Simonson D; Ferrannini E
Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus.
Diabetologia 1982;23(4):313-9.
1982: Bia J M; Tyler K; DeFronzo R A
The effect of dexamethasone on renal electrolyte excretion in the adrenalectomized rat.
Endocrinology 1982;111(3):882-8.
1982: DeFronzo R A; Hendler R; Simonson D
Insulin resistance is a prominent feature of insulin-dependent diabetes.
Diabetes 1982;31(9):795-801.
1982: Jacot E; Defronzo R A; Jéquier E; Maeder E; Felber J P
The effect of hyperglycemia, hyperinsulinemia, and route of glucose administration on glucose oxidation and glucose storage.
Metabolism: clinical and experimental 1982;31(9):922-30.
1982: DeFronzo R A; Ferrannini E
Influence of plasma glucose and insulin concentration on plasma glucose clearance in man.
Diabetes 1982;31(8 Pt 1):683-8.
1982: Wahren J; Juhlin-Dannfelt A; Björkman O; DeFronzo R; Felig P
Influence of fibre ingestion on carbohydrate utilization and absorption.
Clinical physiology (Oxford, England) 1982;2(4):315-21.
1982: Smith D; DeFronzo R A
Insulin resistance in uremia mediated by postbinding defects.
Kidney international 1982;22(1):54-62.
1982: Bia M J; Tyler K A; DeFronzo R A
Regulation of extrarenal potassium homeostasis by adrenal hormones in rats.
The American journal of physiology 1982;242(6):F641-4.
1982: DeFronzo R A; Ferrannini E
The pathogenesis of non-insulin-dependent diabetes: an update.
Medicine 1982;61(3):125-40.
1982: Ferrannini E; DeFronzo R A; Sherwin R S
Transient hepatic response to glucagon in man: role of insulin and hyperglycemia.
The American journal of physiology 1982;242(2):E73-81.
1982: Ferrannini E; Barrett E; Bevilacqua S; Dupre J; Defronzo R A
Sodium elevates the plasma glucose response to glucose ingestion in man.
The Journal of clinical endocrinology and metabolism 1982;54(2):455-8.
1982: DeFronzo R A; Thier S O
Inherited tubule disorders.
Hospital practice (Office ed.) 1982;17(2):111-7, 121-8.
1982: Koivisto V A; DeFronzo R; Hendler R; Felig P
The difference in insulin sensitivity and metabolic response to acute exercise in trained and sedentary subjects.
Current problems in clinical biochemistry 1982;11():122-32.
1982: DeFronzo R A; Bia M; Smith D
Clinical disorders of hyperkalemia.
Annual review of medicine 1982;33():521-54.
1982: Simonson D; DeFronzo R A
Hypophosphatemia and glucose intolerance.
Advances in experimental medicine and biology 1982;151():217-28.
1982: DeFronzo R A
Insulin secretion, insulin resistance, and obesity.
International journal of obesity 1982;6 Suppl 1():73-82.
1981: DeFronzo R A; Ferrannini E; Sato Y; Felig P; Wahren J
Synergistic interaction between exercise and insulin on peripheral glucose uptake.
The Journal of clinical investigation 1981;68(6):1468-74.
1981: DeFronzo R A; Jacot E; Jequier E; Maeder E; Wahren J; Felber J P
The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization.
Diabetes 1981;30(12):1000-7.
1981: DeFronzo R A
The effect of insulin on renal sodium metabolism. A review with clinical implications.
Diabetologia 1981;21(3):165-71.
1981: DeFronzo R A; Binder C; Wahren J; Felig P; Ferrannini E; Faber O K
Sensitivity of insulin secretion to feedback inhibition by hyperinsulinaemia.
Acta endocrinologica 1981;98(1):81-6.
1981: DeFronzo R A; Bia M; Birkhead G
Epinephrine and potassium homeostasis.
Kidney international 1981;20(1):83-91.
1981: DeFronzo R A
Glucose intolerance and aging.
Diabetes care 1981;4(4):493-501.
1981: Bevilacqua S; Barrett E; Ferrannini E; Gusberg R; Stewart A; Richardson L; Smith D; DeFronzo R
Lack of effect of parathyroid hormone on hepatic glucose metabolism in the dog.
Metabolism: clinical and experimental 1981;30(5):469-75.
1981: Bia M J; DeFronzo R A
Extrarenal potassium homeostasis.
The American journal of physiology 1981;240(4):F257-68.
1981: DeFronzo R A; Alvestrand A; Smith D; Hendler R; Hendler E; Wahren J
Insulin resistance in uremia.
The Journal of clinical investigation 1981;67(2):563-8.
1981: DeFronzo R A
Insulin and renal sodium handling: clinical implications.
International journal of obesity 1981;5 suppl 1():93-104.
1981: Defronzo R A; Simonson D; Ferrannini E; Barrett E
Insulin resistance: a universal finding in diabetic states.
Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften 1981;():223-38.
1980: DeFronzo R A; Lang R
Hypophosphatemia and glucose intolerance: evidence for tissue insensitivity to insulin.
The New England journal of medicine 1980;303(22):1259-63.
1980: Rasmussen H; Baron R; Broadus A; DeFronzo R; Lang R; Horst R
1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia.
The American journal of medicine 1980;69(3):360-8.
1980: Defronzo R
Retraction. Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man.
Diabetes 1980;29(8):672.
1980: DeFronzo R A; Thier S O
Pathophysiologic approach to hyponatremia.
Archives of internal medicine 1980;140(7):897-902.
1980: DeFronzo R A; Alvestrand A
Glucose intolerance in uremia: site and mechanism.
The American journal of clinical nutrition 1980;33(7):1438-45.
1980: DeFronzo R A; Felig P
Amino acid metabolism in uremia: insights gained from normal and diabetic man.
The American journal of clinical nutrition 1980;33(7):1378-86.
1980: DeFronzo R A; Felig P; Ferrannini E; Wahren J
Effect of graded doses of insulin on splanchnic and peripheral potassium metabolism in man.
The American journal of physiology 1980;238(5):E421-7.
1980: DeFronzo R A; Lee R; Jones A; Bia M
Effect of insulinopenia and adrenal hormone deficiency on acute potassium tolerance.
Kidney international 1980;17(5):586-94.
1980: Deibert D C; DeFronzo R A
Epinephrine-induced insulin resistance in man.
The Journal of clinical investigation 1980;65(3):717-21.
1980: Mandell I N; DeFronzo R A; Robertson G L; Forrest J N
Role of plasma arginine vasopressin in the impaired water diuresis of isolated glucocorticoid deficiency in the rat.
Kidney international 1980;17(2):186-95.
1980: Soman V R; DeFronzo R A
Direct evidence for downregulation of insulin receptors by physiologic hyperinsulinemia in man.
Diabetes 1980;29(2):159-63.
1980: DeFronzo R A; Hendler R; Christensen N
Stimulation of counterregulatory hormonal responses in diabetic man by a fall in glucose concentration.
Diabetes 1980;29(2):125-31.
1980: Ferrannini E; Wahren J; Felig P; DeFronzo R A
The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man.
Metabolism: clinical and experimental 1980;29(1):28-35.
1980: DeFronzo R A
Hyperkalemia and hyporeninemic hypoaldosteronism.
Kidney international 1980;17(1):118-34.
1980: Koivisto V A; Soman V R; Defronzo R; Felig P
Effects of acute exercise and training on insulin binding to monocytes and insulin sensitivity in vivo.
Acta paediatrica Scandinavica. Supplement 1980;283():70-8.
1980: DeFronzo R A; Sherwin R S; Felig P
Synergistic interactions of counterregulatory hormones: a mechanism for stress hyperglycemia.
Acta chirurgica Scandinavica. Supplementum 1980;498():33-42.
1979: Defronzo R A
Glucose intolerance and aging: evidence for tissue insensitivity to insulin.
Diabetes 1979;28(12):1095-101.
1979: Soman V R; Koivisto V A; Deibert D; Felig P; DeFronzo R A
Increased insulin sensitivity and insulin binding to monocytes after physical training.
The New England journal of medicine 1979;301(22):1200-4.
1979: DeFronzo R A; Tobin J; Boden G; Andres R
The role of growth hormone in the glucose intolerance of uremia.
Acta diabetologica latina 1979;16(4):279-86.
1979: DeFronzo R A; Tobin J D; Andres R
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
The American journal of physiology 1979;237(3):E214-23.
1979: Mahnensmith R; Thier S O; Cooke C R; Broadus A; DeFronzo R A
Effect of acute metabolic acidemia on renal electrolyte transport in man.
Metabolism: clinical and experimental 1979;28(8):831-42.
1979: DeFronzo R; Deibert D; Hendler R; Felig P; Soman V
Insulin sensitivity and insulin binding to monocytes in maturity-onset diabetes.
The Journal of clinical investigation 1979;63(5):939-46.
1979: DeFronzo R A; Beckles A D
Glucose intolerance following chronic metabolic acidosis in man.
The American journal of physiology 1979;236(4):E328-34.
1979: DeFronzo R A; Taufield P A; Black H; McPhedran P; Cooke C R
Impaired renal tubular potassium secretion in sickle cell disease.
Annals of internal medicine 1979;90(3):310-16.
1979: Gusberg R J; Barrett E; Felig P; DeFronzo R A
Hepatic response to enteral and parenteral glucose in the dog.
Surgical forum 1979;30():74-5.
1978: DeFronzo R A
Pathogenesis of glucose intolerance in uremia.
Metabolism: clinical and experimental 1978;27(12 Suppl 2):1866-80.
1978: Soman V; Tamborlane W; DeFronzo R; Genel M; Felig P
Insulin binding and insulin sensitivity in isolated growth hormone deficiency.
The New England journal of medicine 1978;299(19):1025-30.
1978: DeFronzo R A; Ferrannini E; Hendler R; Wahren J; Felig P
Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange.
Proceedings of the National Academy of Sciences of the United States of America 1978;75(10):5173-7.
1978: DeFronzo R A; Tobin J D; Rowe J W; Andres R
Glucose intolerance in uremia. Quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin.
The Journal of clinical investigation 1978;62(2):425-35.
1978: DeFronzo R A; Soman V; Sherwin R S; Hendler R; Felig P
Insulin binding to monocytes and insulin action in human obesity, starvation, and refeeding.
The Journal of clinical investigation 1978;62(1):204-13.
1978: DeFronzo R A; Cooke C R; Wright J R; Humphrey R L
Renal function in patients with multiple myeloma.
Medicine 1978;57(2):151-66.
1978: DeFronzo R A; Sherwin R S; Dillingham M; Hendler R; Tamborlane W V; Felig P
Influence of basal insulin and glucagon secretion on potassium and sodium metabolism. Studies with somatostatin in normal dogs and in normal and diabetic human beings.
The Journal of clinical investigation 1978;61(2):472-9.
1977: Sherwin R S; Tamborlane W; Hendler R; Saccá L; DeFronzo R A; Felig P
Influence of glucagon replacement on the hyperglycemic and hyperketonemic response to prolonged somatostatin infusion in normal man.
The Journal of clinical endocrinology and metabolism 1977;45(5):1104-7.
1977: DeFronzo R A; Sherwin R S; Felig P; Bia M
Nonuremic diabetic hyperkalemia. Possible role of insulin deficiency.
Archives of internal medicine 1977;137(7):842-3.
1977: DeFronzo R A; Andres R; Bedsoe T A; Boden G; Faloona G A; Tobin J D
A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man.
Diabetes 1977;26(5):445-52.
1977: DeFronzo R A; Goldberg M; Cooke C R; Barker C; Grossman R A; Agus Z S
Investigations into the mechanisms of hyperkalemia following renal transplantation.
Kidney international 1977;11(5):357-65.
1977: DeFronzo R A; Cooke C R; Goldberg M; Cox M; Myers A R; Agus Z S
Impaired renal tubular potassium secretion in systemic lupus erythematosus.
Annals of internal medicine 1977;86(3):268-71.
1977: Sherwin R S; Hendler R; DeFronzo R; Wahren J; Felic P
Glucose homeostasis during prolonged suppression of glucagon and insulin secretion by somatostatin.
Proceedings of the National Academy of Sciences of the United States of America 1977;74(1):348-52.
1976: DeFronzo R A; Siegel N J; Pearson H A
More on the pathogenesis and management of hyponatremia in the crisis of sickle cell disease.
The Journal of pediatrics 1976;89(6):1038-40.
1976: Lau K; DeFronzo R; Morrison G; Rascoff J; Goldberg M; Agus Z S
Effectiveness of bumetanide in nephrotic syndrome: a double-blind crossover study with furosemide.
Journal of clinical pharmacology 1976;16(10 Pt 1):489-97.
1976: DeFronzo R A; Goldberg M; Agus Z S
The effects of glucose and insulin on renal electrolyte transport.
The Journal of clinical investigation 1976;58(1):83-90.
1976: DeFronzo R A; Goldberg M; Agus Z S
Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
Annals of internal medicine 1976;84(5):538-42.
1976: Rowe J W; Shock N W; DeFronzo R A
The influence of age on the renal response to water deprivation in man.
Nephron 1976;17(4):270-8.
1976: Defronzo R A; Thier S O
Functional abnormalities in renal cystic diseases.
Perspectives in nephrology and hypertension 1976;4():65-81.
1975: Humphrey R L; Wright J R; Zachary J B; Sterioff S; DeFronzo R A
Renal transplantation in multiple myeloma. A case report.
Annals of internal medicine 1975;83(5):651-3.
1975: Defronzo R A; Humphrey R L; Wright J R; Cooke C R
Acute renal failure in multiple myeloma.
Medicine 1975;54(3):209-23.
1975: DeFronzo R A; Cooke C R; Andres R; Faloona G R; Davis P J
The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.
The Journal of clinical investigation 1975;55(4):845-55.
1974: DeFronzo R A; Abeloff M; Braine H; Humphrey R L; Davis P J
Renal dysfunction after treatment with isophosphamide (NSC-109724).
Cancer chemotherapy reports. Part 1 1974;58(3):375-82.
1974: DeFronzo R A; Colvin O M; Braine H; Robertson G L; Davis P J
Proceedings: Cyclophosphamide and the kidney.
Cancer 1974;33(2):483-91.
1973: Steel T H; Serpick A A; Block J B; DeFronzo R A; Davis P J; Colvin O M; Braine H
Letter: Water intoxication and cyclophosphamide.
Annals of internal medicine 1973;79(5):763-4.
1973: DeFronzo R A; Andres R; Edgar P; Walker W G
Carbohydrate metabolism in uremia: a review.
Medicine 1973;52(5):469-81.
1973: DeFronzo R A; Braine H; Colvin M; Davis P J
Water intoxication in man after cyclophosphamide therapy. Time course and relation to drug activation.
Annals of internal medicine 1973;78(6):861-9.
1973: DeFronzo R A; Murray G F; Maddrey W C
Aeromonas septicemia from hepatobiliary disease.
The American journal of digestive diseases 1973;18(4):323-31.
1972: DeFronzo R A; Roth W D
Evidence for the existence of a pineal-adrenal and a pineal-thyroid axis.
Acta endocrinologica 1972;70(1):35-42.
1971: DeFronzo R A; Roth W D; Greep R O
Lack of effect of pinealectomy on ovarian function: evidence for a time-dependent action.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1971;138(3):1058-61.

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