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Hemmo Drexhage

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L van Steensel; Hemmo Drexhage; Herbert Hooijkaas; Robert W A M Kuijpers; Dion Paridaens; W A van den Bosch; P Martin van Hagen; Willem A Dik
PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients.
L van Steensel; Hemmo Drexhage; Herbert Hooijkaas; Robert W A M Kuijpers; Dion Paridaens; W A van den Bosch; P Martin van Hagen; M van Meurs; Willem A Dik
Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy.
Kim van der Weerd; Jacques J M van Dongen; Astrid van Huisstede; Willem A Dik; Hemmo Drexhage; Rosalie M Kiewiet; Anton W Langerak; Benjamin Schrijver; Dave H Schweitzer; Frank J T Staal; Maarten O van Aken; Aart-Jan van der Lelij; P Martin van Hagen
Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.

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2012: L van Steensel; Hemmo Drexhage; Herbert Hooijkaas; Robert W A M Kuijpers; Dion Paridaens; W A van den Bosch; P Martin van Hagen; Willem A Dik
PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients.
The Journal of clinical endocrinology and metabolism 2012;97(6):E944-53.
2012: L van Steensel; Hemmo Drexhage; Herbert Hooijkaas; Robert W A M Kuijpers; Dion Paridaens; W A van den Bosch; P Martin van Hagen; M van Meurs; Willem A Dik
Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves' ophthalmopathy.
The Journal of clinical endocrinology and metabolism 2012;97(3):E400-8.
2012: Kim van der Weerd; Jacques J M van Dongen; Astrid van Huisstede; Willem A Dik; Hemmo Drexhage; Rosalie M Kiewiet; Anton W Langerak; Benjamin Schrijver; Dave H Schweitzer; Frank J T Staal; Maarten O van Aken; Aart-Jan van der Lelij; P Martin van Hagen
Morbidly obese human subjects have increased peripheral blood CD4+ T cells with skewing toward a Treg- and Th2-dominated phenotype.
Diabetes 2012;61(2):401-8.
2012: Jojanneke M C Welzen-Coppens; Cornelia G van Helden-Meeuwsen; Hemmo Drexhage; Marjan A Versnel
Abnormalities of dendritic cell precursors in the pancreas of the NOD mouse model of diabetes.
European journal of immunology 2012;42(1):186-94.
2011: Roosmarijn C Drexhage; Thomas H Hoogenboezem; Willem A Nolen; Marjan A Versnel; Arie Berghout; Hemmo Drexhage
The activation of monocyte and T cell networks in patients with bipolar disorder.
Brain, behavior, and immunity 2011;25(6):1206-13.
2011: Karin Weigelt; Annemarie Wijkhuijs; Harm de Wit; Roos C Drexhage; Nico J M van Beveren; Veerle Bergink; Tom K Birkenhäger; Livia A Carvalho; Hemmo Drexhage
TREM-1 and DAP12 expression in monocytes of patients with severe psychiatric disorders. EGR3, ATF3 and PU.1 as important transcription factors.
Brain, behavior, and immunity 2011;25(6):1162-9.
2011: Roosmarijn C Drexhage; Thomas A Hoogenboezem; Willem A Nolen; Nico J M van Beveren; Marjan A Versnel; Dan Cohen; Hemmo Drexhage
An activated set point of T-cell and monocyte inflammatory networks in recent-onset schizophrenia patients involves both pro- and anti-inflammatory forces.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2011;14(6):746-55.
2011: Leendert van Steensel; P Martin van Hagen; Dion Paridaens; Robert W A M Kuijpers; Willem A van den Bosch; Hemmo Drexhage; Herbert Hooijkaas; Willem A Dik
Whole orbital tissue culture identifies imatinib mesylate and adalimumab as potential therapeutics for Graves' ophthalmopathy.
The British journal of ophthalmology 2011;95(5):735-8.
2011: Veerle Bergink; Roos C Drexhage; Hans Kuijpens; Steven A Kushner; Mijke van den Berg; Willem A Nolen; Victor Pop; Wilmar Wiersinga; Hemmo Drexhage
Prevalence of autoimmune thyroid dysfunction in postpartum psychosis.
The British journal of psychiatry : the journal of mental science 2011;198(4):264-8.
2011: Roosmarijn C Drexhage; Willem A Nolen; Nico J M van Beveren; Marjan A Versnel; Karin Weigelt; Dan Cohen; Hemmo Drexhage
Immune and neuroimmune alterations in mood disorders and schizophrenia.
International review of neurobiology 2011;101():169-201.
2010: Roosmarijn C Drexhage; Leonie van der Heul-Nieuwenhuijsen; Roos C Padmos; Nico van Beveren; Dan Cohen; Marjan A Versnel; Willem A Nolen; Hemmo Drexhage
Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2010;13(10):1369-81.
2010: Huriya Beyan; Roosmarijn C Drexhage; Leonie van der Heul Nieuwenhuijsen; Harm de Wit; Roosmarijn C Padmos; Nanette C Schloot; Hemmo Drexhage; richard leslie
Monocyte gene-expression profiles associated with childhood-onset type 1 diabetes and disease risk: a study of identical twins.
Diabetes 2010;59(7):1751-5.
2010: Leonie van der Heul-Nieuwenhuijsen; Roos C Padmos; Roosmarijn C Drexhage; Harm de Wit; Arie Berghout; Hemmo Drexhage
An inflammatory gene-expression fingerprint in monocytes of autoimmune thyroid disease patients.
The Journal of clinical endocrinology and metabolism 2010;95(4):1962-71.
2010: Leendert van Steensel; Dion Paridaens; Gemma M Dingjan; P L A van Daele; P Martin van Hagen; Robert W A M Kuijpers; Willem A van den Bosch; Hemmo Drexhage; Herbert Hooijkaas; Willem A Dik
Platelet-derived growth factor-BB: a stimulus for cytokine production by orbital fibroblasts in Graves' ophthalmopathy.
Investigative ophthalmology & visual science 2010;51(2):1002-7.
2010: Roosmarijn C Drexhage; Esther M Knijff; Roos C Padmos; Leonie van der Heul-Nieuwenhuijzen; Wouter Beumer; Marjan A Versnel; Hemmo Drexhage
The mononuclear phagocyte system and its cytokine inflammatory networks in schizophrenia and bipolar disorder.
Expert review of neurotherapeutics 2010;10(1):59-76.
2009: Roos C Padmos; G Caroline M van Baal; Ronald Vonk; Annemarie J M Wijkhuijs; René S Kahn; Willem A Nolen; Hemmo Drexhage
Genetic and environmental influences on pro-inflammatory monocytes in bipolar disorder: a twin study.
Archives of general psychiatry 2009;66(9):957-65.
2009: Leendert van Steensel; Dion Paridaens; Benjamin Schrijver; Gemma M Dingjan; Paul L A van Daele; P Martin van Hagen; Willem A van den Bosch; Hemmo Drexhage; Herbert Hooijkaas; Willem A Dik
Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy.
Investigative ophthalmology & visual science 2009;50(7):3091-8.
2009: Cindy Jm Loomans; Rien van Haperen; Jacques M Duijs; Caroline Verseyden; Rini de Crom; Pieter J M Leenen; Hemmo Drexhage; Hetty C de Boer; Eelco Jp de Koning; Ton J Rabelink; Frank Staal; Anton-Jan van Zonneveld
Differentiation of bone marrow-derived endothelial progenitor cells is shifted into a proinflammatory phenotype by hyperglycemia.
Molecular medicine (Cambridge, Mass.) 2009;15(5-6):152-9.
2009: M E Wildenberg; J M C Welzen-Coppens; Cornelia G Van Helden-Meeuwsen; H Bootsma; A Vissink; N van Rooijen; Joop P van de Merwe; Hemmo Drexhage; M A Versnel
Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome.
Annals of the rheumatic diseases 2009;68(3):420-6.
2009: Tatjana Nikolic; Jojanneke M C Welzen-Coppens; Pieter J M Leenen; Hemmo Drexhage; Marjan A Versnel
Plasmacytoid dendritic cells in autoimmune diabetes - potential tools for immunotherapy.
Immunobiology 2009;214(9-10):791-9.
2008: Hui Wan; Cornelia G Van Helden-Meeuwsen; Cecilia Garlanda; Lonneke M E Leijten; virginia maina; Nisar A Khan; Hemmo Drexhage; Alberto Mantovani; Robbert Benner; Marjan A Versnel
Chorionic gonadotropin up-regulates long pentraxin 3 expression in myeloid cells.
Journal of leukocyte biology 2008;84(5):1346-52.
2008: Roos C Padmos; Nanette C Schloot; Huriya Beyan; Cindy Ruwhof; Frank Staal; Dick de Ridder; Henk-Jan Aanstoot; Wai-Kwan Lam-Tse; Harm de Wit; Christian de Herder; Roos C Drexhage; Barbara Menart; R David G Leslie; Hemmo Drexhage
Distinct monocyte gene-expression profiles in autoimmune diabetes.
Diabetes 2008;57(10):2768-73.
2008: Manon E Wildenberg; Cornelia G Van Helden-Meeuwsen; Joop P van de Merwe; Hemmo Drexhage; Marjan A Versnel
Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cells.
European journal of immunology 2008;38(7):2024-33.
2008: Manon E Wildenberg; Cornelia G Van Helden-Meeuwsen; Joop P van de Merwe; Christophe Moreno; Hemmo Drexhage; Marjan A Versnel
Lack of CCR5 on dendritic cells promotes a proinflammatory environment in submandibular glands of the NOD mouse.
Journal of leukocyte biology 2008;83(5):1194-200.
2008: Roos C Padmos; Manon H J Hillegers; Esther M Knijff; Ronald Vonk; Anne Bouvy; Frank Staal; Dick de Ridder; Ralph W Kupka; Willem A Nolen; Hemmo Drexhage
A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes.
Archives of general psychiatry 2008;65(4):395-407.
2008: Manon E Wildenberg; Cornelia G Van Helden-Meeuwsen; Hemmo Drexhage; Marjan A Versnel
Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland.
Arthritis research & therapy 2008;10(3):R69.
2007: Esther M Knijff; M Nadine Breunis; Ralph W Kupka; Harm J de Wit; Cindy Ruwhof; Grard W Akkerhuis; Willem A Nolen; Hemmo Drexhage
An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment.
Bipolar disorders 2007;9(7):743-53.
2007: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Low-density cells isolated from the rat thymus resemble branched cortical macrophages and have a reduced capability of rescuing double-positive thymocytes from apoptosis in the BB-DP rat.
Journal of leukocyte biology 2007;82(4):869-76.
2007: Ronald Vonk; Astrid C van der Schot; René S Kahn; Willem A Nolen; Hemmo Drexhage
Is autoimmune thyroiditis part of the genetic vulnerability (or an endophenotype) for bipolar disorder?
Biological psychiatry 2007;62(2):135-40.
2007: Manon H J Hillegers; Catrien G Reichart; Marjolein Wals; Frank C Verhulst; Johan Ormel; Willem A Nolen; Hemmo Drexhage
Signs of a higher prevalence of autoimmune thyroiditis in female offspring of bipolar parents.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2007;17(6-7):394-9.
2007: Esther Korpershoek; Aart M Verwest; Ynske IJzendoorn; Robbert Rottier; Hemmo Drexhage; Ronald R de Krijger
Expression of GAD67 and novel GAD67 splice variants during human fetal pancreas development: GAD67 expression in the fetal pancreas.
Endocrine pathology 2007;18(1):31-6.
2006: Esther M Knijff; M Nadine Breunis; Marielle C van Geest; Ralph W Kupka; Cindy Ruwhof; Harm J de Wit; Willem A Nolen; Hemmo Drexhage
A relative resistance of T cells to dexamethasone in bipolar disorder.
Bipolar disorders 2006;8(6):740-50.
2006: Cindy J M Loomans; H Wan; Rini de Crom; Rien van Haperen; Hetty C de Boer; Pieter J M Leenen; Hemmo Drexhage; ton rabelink; Anton-Jan van Zonneveld; Frank Staal
Angiogenic murine endothelial progenitor cells are derived from a myeloid bone marrow fraction and can be identified by endothelial NO synthase expression.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(8):1760-7.
2006: Frank Jan de Jong; Tom Den Heijer; Theo J Visser; Yolanda B De Rijke; Hemmo Drexhage; Albert Hofman; Monique Breteler
Thyroid hormones, dementia, and atrophy of the medial temporal lobe.
The Journal of clinical endocrinology and metabolism 2006;91(7):2569-73.
2006: Britte C Beaudette-Zlatanova; Barbara J Whalen; Danny Zipris; Hideo Yagita; Jan Rozing; Herman Groen; C D Benjamin; T Hunig; Hemmo Drexhage; Mohammed Javeed I Ansari; Jean Leif; John P Mordes; Dale L Greiner; Mohamed H Sayegh; Aldo A Rossini
Costimulation and autoimmune diabetes in BB rats.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(5 Pt 1):894-902.
2006: Thea G A Strieder; Hemmo Drexhage; Wai-Kwan Lam-Tse; Mark F Prummel; Jan G P Tijssen; Wilmar M Wiersinga
A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?
Autoimmunity 2006;39(2):93-8.
2006: Thjon J Tang; Dragica Vukosavljevic; Harry L A Janssen; Rekha S Binda; Shanta Mancham; Hugo W Tilanus; Jan N M Ijzermans; Hemmo Drexhage; Jaap Kwekkeboom
Aberrant composition of the dendritic cell population in hepatic lymph nodes of patients with hepatocellular carcinoma.
Human pathology 2006;37(3):332-8.
2006: Esther M Knijff; Cindy Ruwhof; Harm J de Wit; Ralph W Kupka; Ronald Vonk; Grard W Akkerhuis; Willem A Nolen; Hemmo Drexhage
Monocyte-derived dendritic cells in bipolar disorder.
Biological psychiatry 2006;59(4):317-26.
2006: Hemmo Drexhage
Are there more than antibodies to the thyroid-stimulating hormone receptor that meet the eye in Graves' disease?
Endocrinology 2006;147(1):9-12.
2005: Sacha Geutskens; Timo Otonkoski; Mari-Anne Pulkkinen; Hemmo Drexhage; Pieter J M Leenen
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro.
Journal of leukocyte biology 2005;78(4):845-52.
2005: Gerben Bouma; Jojanneke M C Coppens; Wai-Kwan Lam-Tse; W Luini; Kees Sintnicolaas; Wilfried H B M Levering; Silvano Sozzani; Hemmo Drexhage; Marjan A Versnel
An increased MRP8/14 expression and adhesion, but a decreased migration towards proinflammatory chemokines of type 1 diabetes monocytes.
Clinical and experimental immunology 2005;141(3):509-17.
2005: Gerben Bouma; Jojanneke M C Coppens; Sabine Mourits; Tatjana Nikolic; Silvano Sozzani; Hemmo Drexhage; Marjan A Versnel
Evidence for an enhanced adhesion of DC to fibronectin and a role of CCL19 and CCL21 in the accumulation of DC around the pre-diabetic islets in NOD mice.
European journal of immunology 2005;35(8):2386-96.
2005: Esther M Knijff; Ralph W Kupka; Cindy Ruwhof; M Nadine Breunis; Errol P Prens; Willem A Nolen; Hemmo Drexhage
Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasis.
Bipolar disorders 2005;7(4):388-9.
2005: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Aberrancies in the differentiation and maturation of dendritic cells from bone-marrow precursors are linked to various genes on chromosome 4 and other chromosomes of the BB-DP rat.
Journal of autoimmunity 2005;25(1):1-12.
2005: Vinod Sommandas; Elizabeth A Rutledge; Brian Van Yserloo; Jessica Fuller; Ake Lernmark; Hemmo Drexhage
Defects in differentiation of bone-marrow derived dendritic cells of the BB rat are partly associated with IDDM2 (the lyp gene) and partly associated with other genes in the BB rat background.
Journal of autoimmunity 2005;25(1):46-56.
2005: P P C Boor; Jan N M Ijzermans; Renate G van der Molen; Rekha S Binda; Shanta Mancham; Herold J Metselaar; Johannes G Kusters; Esther de Jong; Hemmo Drexhage; Jaap Kwekkeboom
Immunomagnetic selection of functional dendritic cells from human lymph nodes.
Immunology letters 2005;99(2):162-8.
2005: Tatjana Nikolic; Gerben Bouma; Hemmo Drexhage; Pieter J M Leenen
Diabetes-prone NOD mice show an expanded subpopulation of mature circulating monocytes, which preferentially develop into macrophage-like cells in vitro.
Journal of leukocyte biology 2005;78(1):70-9.
2005: Tatjana Nikolic; Sacha Geutskens; Nico van Rooijen; Hemmo Drexhage; Pieter J M Leenen
Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study.
Laboratory investigation; a journal of technical methods and pathology 2005;85(4):487-501.
2005: Jaap Kwekkeboom; P P C Boor; E Sen; Johannes G Kusters; Hemmo Drexhage; Esther C de Jong; Hugo W Tilanus; Jan N M Ijzermans; Herold J Metselaar
Human liver myeloid dendritic cells maturate in vivo into effector DC with a poor allogeneic T-cell stimulatory capacity.
Transplantation proceedings 2005;37(1):15-6.
2005: Gerben Bouma; Tatjana Nikolic; Jojanneke M C Coppens; Cornelia G Van Helden-Meeuwsen; Pieter J M Leenen; Hemmo Drexhage; Silvano Sozzani; Marjan A Versnel
NOD mice have a severely impaired ability to recruit leukocytes into sites of inflammation.
European journal of immunology 2005;35(1):225-35.
2004: Sacha Geutskens; Françoise Homo-Delarche; Jean-Marie Pleau; Sylvie Durant; Hemmo Drexhage; Wilson Savino
Extracellular matrix distribution and islet morphology in the early postnatal pancreas: anomalies in the non-obese diabetic mouse.
Cell and tissue research 2004;318(3):579-89.
2004: Roos C Padmos; Lynn Bekris; Esther M Knijff; Henning Tiemeier; Ralph W Kupka; Dan Cohen; Willem A Nolen; Ake Lernmark; Hemmo Drexhage
A high prevalence of organ-specific autoimmunity in patients with bipolar disorder.
Biological psychiatry 2004;56(7):476-82.
2004: Tatjana Nikolic; Marjolijn Bunk; Hemmo Drexhage; Pieter J M Leenen
Bone marrow precursors of nonobese diabetic mice develop into defective macrophage-like dendritic cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(7):4342-51.
2004: Esther Korpershoek; Pieter J M Leenen; Hemmo Drexhage; Ronald R de Krijger
Cellular composition of pancreas-associated lymphoid tissue during human fetal pancreatic development.
Histopathology 2004;45(3):291-7.
2004: Gerben Bouma; Wai-Kwan Lam-Tse; Annet F Wierenga-Wolf; Hemmo Drexhage; Marjan A Versnel
Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin.
Diabetes 2004;53(8):1979-86.
2004: Françoise Homo-Delarche; Hemmo Drexhage
Immune cells, pancreas development, regeneration and type 1 diabetes.
Trends in immunology 2004;25(5):222-9.
2004: W Tanis; Shanta Mancham; Rekha S Binda; Harry L A Janssen; G Bezemer; Jan N M Ijzermans; Hugo W Tilanus; J D Laman; H de Wit; Hemmo Drexhage; Solko W Schalm; Jaap Kwekkeboom
Human hepatic lymph nodes contain normal numbers of mature myeloid dendritic cells but few plasmacytoid dendritic cells.
Clinical immunology (Orlando, Fla.) 2004;110(1):81-8.
2003: Wai-Kwan Lam-Tse; Manou R Batstra; Bobby P C Koeleman; Bart O Roep; Mu G J Bruining; Henk-Jan Aanstoot; Hemmo Drexhage
The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes.
Pediatric endocrinology reviews : PER 2003;1(1):22-37.
2003: Martha O Canning; Cindy Ruwhof; Hemmo Drexhage
Aberrancies in antigen-presenting cells and T cells in autoimmune thyroid disease. A role in faulty tolerance induction.
Autoimmunity 2003;36(6-7):429-42.
2003: Sylvie Durant; Sacha Geutskens; Saskia C A van Blokland; Josiane Coulaud; Véronique Alves; Jean-Marie Pleau; Marjan A Versnel; Hemmo Drexhage; Françoise Homo-Delarche
Proapoptosis and antiapoptosis-related molecules during postnatal pancreas development in control and nonobese diabetic mice: relationship with innervation.
Laboratory investigation; a journal of technical methods and pathology 2003;83(2):227-39.
2003: M Nadine Breunis; Ralph W Kupka; Willem A Nolen; Trisha Suppes; Kirk D Denicoff; Gabriele S Leverich; Robert M Post; Hemmo Drexhage
High numbers of circulating activated T cells and raised levels of serum IL-2 receptor in bipolar disorder.
Biological psychiatry 2003;53(2):157-65.
2003: Saskia C A van Blokland; Cornelia G Van Helden-Meeuwsen; Annet F Wierenga-Wolf; Dennis Tielemans; Hemmo Drexhage; Joop P van de Merwe; Françoise Homo-Delarche; Marjan A Versnel
Apoptosis and apoptosis-related molecules in the submandibular gland of the nonobese diabetic mouse model for Sjögren's syndrome: limited role for apoptosis in the development of sialoadenitis.
Laboratory investigation; a journal of technical methods and pathology 2003;83(1):3-11.
2002: Wai-Kwan Lam-Tse; A Lernmark; Hemmo Drexhage
Animal models of endocrine/organ-specific autoimmune diseases: do they really help us to understand human autoimmunity?
Springer seminars in immunopathology 2002;24(3):297-321.
2002: judith rosmalen; Pieter J M Leenen; Carme Pelegri; Hemmo Drexhage; Françoise Homo-Delarche
Islet abnormalities in the pathogenesis of autoimmune diabetes.
Trends in endocrinology and metabolism: TEM 2002;13(5):209-14.
2002: Cindy Ruwhof; Martha O Canning; Kristel Grotenhuis; Harm J de Wit; Zenovia Z Florencia; Meeny de Haan-Meulman; Hemmo Drexhage
Accessory cells with a veiled morphology and movement pattern generated from monocytes after avoidance of plastic adherence and of NADPH oxidase activation. A comparison with GM-CSF/IL-4-induced monocyte-derived dendritic cells.
Immunobiology 2002;205(3):247-66.
2002: S Charré; judith rosmalen; Carme Pelegri; Véronique Alves; Pieter J M Leenen; Hemmo Drexhage; Françoise Homo-Delarche
Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period.
Histology and histopathology 2002;17(2):393-401.
2002: Ralph W Kupka; Willem A Nolen; Robert M Post; Susan L McElroy; Lori L Altshuler; Kirk D Denicoff; Mark A Frye; Paul E Keck; Gabriele S Leverich; A John Rush; Trisha Suppes; Chad Pollio; Hemmo Drexhage
High rate of autoimmune thyroiditis in bipolar disorder: lack of association with lithium exposure.
Biological psychiatry 2002;51(4):305-11.
2002: Ralph W Kupka; M Nadine Breunis; Esther M Knijff; Cindy Ruwhof; Willem A Nolen; Hemmo Drexhage
Immune activation, steroid resistancy and bipolar disorder.
Bipolar disorders 2002;4 Suppl 1():73-4.
2002: P M J Kalkman; W J Fokkens; H J de Wit; Joop P van de Merwe; Herbert Hooijkaas; J M W van Haarst; Henk C Hoogsteden; Hemmo Drexhage
A hampered chemoattractant-induced cytoskeletal rearrangement in granulocytes of patients with unexplained severe chronic and relapsing infections of the upper and lower airways. In vitro restoration by G-CSF exposure.
Clinical and experimental immunology 2002;127(1):115-22.
2001: Johannes L P Kuijpens; Huib L Vader; Hemmo Drexhage; WM Wiersinga; Maarten J M Van Son; Victor J Pop
Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(5):579-84.
2001: Alex F Muller; Hemmo Drexhage; Arie Berghout
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care.
Endocrine reviews 2001;22(5):605-30.
2001: Martha O Canning; Kristel Grotenhuis; Harm J de Wit; Cindy Ruwhof; Hemmo Drexhage
1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(3):351-7.
2001: Martha O Canning; Kristel Grotenhuis; Meeny de Haan-Meulman; Harm J de Wit; Arie Berghout; Hemmo Drexhage
An abnormal adherence of monocytes to fibronectin in thyroid autoimmunity has consequences for cell polarization and the development of veiled cells.
Clinical and experimental immunology 2001;125(1):10-8.
2001: Carme Pelegri; judith rosmalen; Sylvie Durant; Mark Throsby; V Alvès; Josiane Coulaud; A Esling; Jean-Marie Pléau; Hemmo Drexhage; Françoise Homo-Delarche
Islet endocrine-cell behavior from birth onward in mice with the nonobese diabetic genetic background.
Molecular medicine (Cambridge, Mass.) 2001;7(5):311-9.
2001: Cindy Ruwhof; Hemmo Drexhage
Iodine and thyroid autoimmune disease in animal models.
Thyroid : official journal of the American Thyroid Association 2001;11(5):427-36.
2001: FG Delemarre; Patricia G Hoogeveen; Meeny de Haan-Meulman; PJ Simons; Hemmo Drexhage
Homotypic cluster formation of dendritic cells, a close correlate of their state of maturation. Defects in the biobreeding diabetes-prone rat.
Journal of leukocyte biology 2001;69(3):373-80.
2001: judith rosmalen; M J Pigmans; R Kersseboom; Hemmo Drexhage; Pieter J M Leenen; Françoise Homo-Delarche
Sex steroids influence pancreatic islet hypertrophy and subsequent autoimmune infiltration in nonobese diabetic (NOD) and NODscid mice.
Laboratory investigation; a journal of technical methods and pathology 2001;81(2):231-9.
2001: V H van der Velden; P J Leenen; Hemmo Drexhage
CD13/aminopeptidase N involvement in dendritic cell maturation.
Leukemia 2001;15(1):190-1.
2000: Sandra Kalmijn; Kala M Mehta; H A Pols; Albert Hofman; Hemmo Drexhage; Monique Breteler
Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study.
Clinical endocrinology 2000;53(6):733-7.
2000: Saskia C A van Blokland; Annet F Wierenga-Wolf; Cornelia G Van Helden-Meeuwsen; Hemmo Drexhage; Herbert Hooijkaas; Joop P van de Merwe; Marjan A Versnel
Professional antigen presenting cells in minor salivary glands in Sjögren's syndrome: potential contribution to the histopathological diagnosis?
Laboratory investigation; a journal of technical methods and pathology 2000;80(12):1935-41.
2000: PJ Simons; FG Delemarre; Hemmo Drexhage
A functional and phenotypic study on immune accessory cells isolated from the thyroids of Wistar and autoimmune-prone BB-DP rats.
Journal of autoimmunity 2000;15(4):417-24.
2000: G T Verhoeven; J M Van Haarst; H J De Wit; P J Simons; H C Hoogsteden; Hemmo Drexhage
Glucocorticoids hamper the ex vivo maturation of lung dendritic cells from their low autofluorescent precursors in the human bronchoalveolar lavage: decreases in allostimulatory capacity and expression of CD80 and CD86.
Clinical and experimental immunology 2000;122(2):232-40.
2000: Martha O Canning; Kristel Grotenhuis; Harm J de Wit; Hemmo Drexhage
Opposing effects of dehydroepiandrosterone and dexamethasone on the generation of monocyte-derived dendritic cells.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(5):687-95.
2000: judith rosmalen; Françoise Homo-Delarche; Sylvie Durant; Marcel Kap; Pieter J M Leenen; Hemmo Drexhage
Islet abnormalities associated with an early influx of dendritic cells and macrophages in NOD and NODscid mice.
Laboratory investigation; a journal of technical methods and pathology 2000;80(5):769-77.
2000: Saskia C A van Blokland; Cornelia G Van Helden-Meeuwsen; Annet F Wierenga-Wolf; Hemmo Drexhage; Herbert Hooijkaas; Joop P van de Merwe; Marjan A Versnel
Two different types of sialoadenitis in the NOD- and MRL/lpr mouse models for Sjögren's syndrome: a differential role for dendritic cells in the initiation of sialoadenitis?
Laboratory investigation; a journal of technical methods and pathology 2000;80(4):575-85.
2000: Erik J Giltay; Johanna C M Fonk; B M von Blomberg; Hemmo Drexhage; Casper G Schalkwijk; Louis J G Gooren
In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans.
The Journal of clinical endocrinology and metabolism 2000;85(4):1648-57.
2000: A Elisabeth Hak; Huibert A P Pols; Theo J Visser; Hemmo Drexhage; Albert Hofman; Jacqueline C M Witteman
Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study.
Annals of internal medicine 2000;132(4):270-8.
2000: judith rosmalen; T Martin; Cathleen Dobbs; Jane S A Voerman; Hemmo Drexhage; Kathryn Haskins; Pieter J M Leenen
Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes.
Laboratory investigation; a journal of technical methods and pathology 2000;80(1):23-30.
1999: Katarina Radosevic; K M Casteels; C Mathieu; Willem van Ewijk; Hemmo Drexhage; Pieter J M Leenen
Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?
Journal of autoimmunity 1999;13(4):373-82.
1999: JD Kerrebijn; A J Balm; jeremy freeman; H-Michael Dosch; Hemmo Drexhage
Who is in control of the immune system in head and neck cancer?
Critical reviews in oncology/hematology 1999;31(1):31-53.
1999: Hemmo Drexhage
[Immunology in medical practice. XX. Organ specific autoimmune diseases].
Nederlands tijdschrift voor geneeskunde 1999;143(19):978-84.
1999: Victor J Pop; Johannes L P Kuijpens; Anneloes L van Baar; Gerda J M Verkerk; M M van Son; Jan J M de Vijlder; Thomas Vulsma; WM Wiersinga; Hemmo Drexhage; Huib L Vader
Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy.
Clinical endocrinology 1999;50(2):149-55.
1999: FG Delemarre; PJ Simons; H J de Heer; Hemmo Drexhage
Signs of immaturity of splenic dendritic cells from the autoimmune prone biobreeding rat: consequences for the in vitro expansion of regulator and effector T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1795-801.
1998: Johannes L P Kuijpens; Victor J Pop; Huib L Vader; Hemmo Drexhage; WM Wiersinga
Prediction of post partum thyroid dysfunction: can it be improved?
European journal of endocrinology / European Federation of Endocrine Societies 1998;139(1):36-43.
1998: PJ Simons; FG Delemarre; Hemmo Drexhage
Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6.
Endocrinology 1998;139(7):3148-56.
1998: Johannes L P Kuijpens; M De Hann-Meulman; Huib L Vader; Victor J Pop; WM Wiersinga; Hemmo Drexhage
Cell-mediated immunity and postpartum thyroid dysfunction: a possibility for the prediction of disease?
The Journal of clinical endocrinology and metabolism 1998;83(6):1959-66.
1998: PJ Simons; FG Delemarre; PH Jeucken; Hemmo Drexhage
Pre-autoimmune thyroid abnormalities in the biobreeding diabetes-prone (BB-DP) rat: a possible relation with the intrathyroid accumulation of dendritic cells and the initiation of the thyroid autoimmune response.
The Journal of endocrinology 1998;157(1):43-51.
1997: W Allaerts; B Salomon; Pieter J M Leenen; S van Wijngaardt; PH Jeucken; S Ruuls; D Klatzmann; Hemmo Drexhage
A population of interstitial cells in the anterior pituitary with a hematopoietic origin and a rapid turnover: a relationship with folliculo-stellate cells?
Journal of neuroimmunology 1997;78(1-2):184-97.
1997: A Hoek; Joop Schoemaker; Hemmo Drexhage
Premature ovarian failure and ovarian autoimmunity.
Endocrine reviews 1997;18(1):107-34.
1997: judith rosmalen; Pieter J M Leenen; J D Katz; Jane S A Voerman; Hemmo Drexhage
Dendritic cells in the autoimmune insulitis in NOD mouse models of diabetes.
Advances in experimental medicine and biology 1997;417():291-4.
1997: A Hoek; W Allaerts; Pieter J M Leenen; Joop Schoemaker; Hemmo Drexhage
Dendritic cells and macrophages in the pituitary and the gonads. Evidence for their role in the fine regulation of the reproductive endocrine response.
European journal of endocrinology / European Federation of Endocrine Societies 1997;136(1):8-24.
1997: W Allaerts; PH Jeucken; R Debets; S Hoefakker; E Claassen; Hemmo Drexhage
Heterogeneity of pituitary folliculo-stellate cells: implications for interleukin-6 production and accessory function in vitro.
Journal of neuroendocrinology 1997;9(1):43-53.
1996: J M van Haarst; G T Verhoeven; H J de Wit; Henk C Hoogsteden; R Debets; Hemmo Drexhage
CD1a+ and CD1a- accessory cells from human bronchoalveolar lavage differ in allostimulatory potential and cytokine production.
American journal of respiratory cell and molecular biology 1996;15(6):752-9.
1996: JD Kerrebijn; P J Simons; M Tas; Paul P Knegt; M W Van de Brekel; P Delaere; I B Tan; Hemmo Drexhage; A J Balm
The effects of thymostimulin on immunological function in patients with head and neck cancer.
Clinical otolaryngology and allied sciences 1996;21(5):455-62.
1996: H A Oomen; A J Schipperijn; Hemmo Drexhage
The prevalence of affective disorder and in particular of a rapid cycling of bipolar disorder in patients with abnormal thyroid function tests.
Clinical endocrinology 1996;45(2):215-23.
1996: FG Delemarre; PJ Simons; Hemmo Drexhage
Histomorphological aspects of the development of thyroid autoimmune diseases: consequences for our understanding of endocrine ophthalmopathy.
Thyroid : official journal of the American Thyroid Association 1996;6(4):369-77.
1996: JD Kerrebijn; P J Simons; A J Balm; M Tas; Paul P Knegt; N de Vries; I B Tan; Hemmo Drexhage
Thymostimulin enhancement of T-cell infiltration into head and neck squamous cell carcinoma.
Head & neck 1996;18(4):335-42.
1996: Hemmo Drexhage
Autoimmunity and thyroid growth. Where do we stand?
European journal of endocrinology / European Federation of Endocrine Societies 1996;135(1):39-45.
1996: A Jansen; judith rosmalen; Françoise Homo-Delarche; M Dardenne; Hemmo Drexhage
Effect of prophylactic insulin treatment on the number of ER-MP23+ macrophages in the pancreas of NOD mice. Is the prevention of diabetes based on beta-cell rest?
Journal of autoimmunity 1996;9(3):341-8.
1996: FG Delemarre; PJ Simons; Hemmo Drexhage
The BB rat as a model for autoimmune thyroiditis: relevance for the pathogenesis of human disease.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104 Suppl 3():10-2.
1996: W Allaerts; Donna M Fluitsma; Elisabeth Hoefsmit; P H Jeucken; Hans Morreau; F T Bosman; Hemmo Drexhage
Immunohistochemical, morphological and ultrastructural resemblance between dendritic cells and folliculo-stellate cells in normal human and rat anterior pituitaries.
Journal of neuroendocrinology 1996;8(1):17-29.
1996: FG Delemarre; Hemmo Drexhage
Leucocyte migration into autoimmune diseased endocrine tissues.
European journal of endocrinology / European Federation of Endocrine Societies 1996;134(1):9-11.
1995: M C Many; S Maniratunga; I Varis; M Dardenne; Hemmo Drexhage; J F Denef
Two-step development of Hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis.
The Journal of endocrinology 1995;147(2):311-20.
1995: A Hoek; Y van Kasteren; M de Haan-Meulman; H Hooijkaas; Joop Schoemaker; Hemmo Drexhage
Analysis of peripheral blood lymphocyte subsets, NK cells, and delayed type hypersensitivity skin test in patients with premature ovarian failure.
American journal of reproductive immunology (New York, N.Y. : 1989) 1995;33(6):495-502.
1995: R de Groot; J J van Dongen; H J Neijens; H Hooijkaas; Hemmo Drexhage
Familial disseminated atypical mycobacterial infection in childhood.
Lancet 1995;345(8955):993.
1995: M Itoh; Dirk G de Rooij; A Jansen; Hemmo Drexhage
Phenotypical heterogeneity of testicular macrophages/dendritic cells in normal adult mice: an immunohistochemical study.
Journal of reproductive immunology 1995;28(3):217-32.
1995: A Jansen; M van Hagen; Hemmo Drexhage
Defective maturation and function of antigen-presenting cells in type 1 diabetes.
Lancet 1995;345(8948):491-2.
1995: JD Kerrebijn; P J Simons; M Tas; A J Balm; Hemmo Drexhage
In vivo effects of thymostimulin treatment on monocyte polarization, dendritic cell clustering and serum p15E-like trans-membrane factors in operable head and neck squamous cell carcinoma patients.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 1995;252(7):409-16.
1995: FG Delemarre; P Mooij; M de Haan-Meulman; PJ Simons; H J de Wit; Hemmo Drexhage
Transition of T3-induced monocyte-derived veiled/dendritic cells into macrophage-like cells by lipopolysaccharide.
Advances in experimental medicine and biology 1995;378():57-9.
1994: Hemmo Drexhage; N M Wulffraat
Endocrine autoimmune diseases.
The Netherlands journal of medicine 1994;45(6):285-93.
1994: J M van Haarst; Henk C Hoogsteden; H J de Wit; G T Verhoeven; Carin E G Havenith; Hemmo Drexhage
Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties.
American journal of respiratory cell and molecular biology 1994;11(3):344-50.
1994: W Allaerts; A M Tijssen; P H Jeucken; Hemmo Drexhage; J de Koning
Influence of folliculo-stellate cells on biphasic luteinizing hormone secretion response to gonadotropin-releasing hormone in rat pituitary cell aggregates.
European journal of endocrinology / European Federation of Endocrine Societies 1994;130(5):530-9.
1994: J M van Haarst; H J de Wit; Hemmo Drexhage; Henk C Hoogsteden
Distribution and immunophenotype of mononuclear phagocytes and dendritic cells in the human lung.
American journal of respiratory cell and molecular biology 1994;10(5):487-92.
1994: A Jansen; Françoise Homo-Delarche; H Hooijkaas; Pieter J M Leenen; M Dardenne; Hemmo Drexhage
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD mice.
Diabetes 1994;43(5):667-75.
1994: P Mooij; PJ Simons; M de Haan-Meulman; H J de Wit; Hemmo Drexhage
Effect of thyroid hormones and other iodinated compounds on the transition of monocytes into veiled/dendritic cells: role of granulocyte-macrophage colony-stimulating factor, tumour-necrosis factor-alpha and interleukin-6.
The Journal of endocrinology 1994;140(3):503-12.
1994: P J Simons; Robert Oostendorp; M P Tas; Hemmo Drexhage
Comparison of retroviral p15E-related factors and interferon alpha in head and neck cancer.
Cancer immunology, immunotherapy : CII 1994;38(3):178-84.
1994: P Mooij; H J de Wit; Hemmo Drexhage
A high iodine intake in Wistar rats results in the development of a thyroid-associated ectopic thymic tissue and is accompanied by a low thyroid autoimmune reactivity.
Immunology 1994;81(2):309-16.
1994: JD Kerrebijn; A J Balm; Paul P Knegt; Cees A Meeuwis; Hemmo Drexhage
Macrophage and dendritic cell infiltration in head and neck squamous-cell carcinoma; an immunohistochemical study.
Cancer immunology, immunotherapy : CII 1994;38(1):31-7.
1993: A Hoek; Y van Kasteren; M de Haan-Meulman; Joop Schoemaker; Hemmo Drexhage
Dysfunction of monocytes and dendritic cells in patients with premature ovarian failure.
American journal of reproductive immunology (New York, N.Y. : 1989) 1993;30(4):207-17.
1993: P Mooij; H J de Wit; Hemmo Drexhage
An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats.
Clinical immunology and immunopathology 1993;69(2):189-98.
1993: Hemmo Drexhage; A O Brinkmann; J Antonie Maassen
[Cell and disease. IX. Receptor pathology].
Nederlands tijdschrift voor geneeskunde 1993;137(44):2243-9.
1993: M C Many; Hemmo Drexhage; J F Denef
High frequency of thymic ectopy in thyroids from autoimmune prone nonobese diabetic female mice.
Laboratory investigation; a journal of technical methods and pathology 1993;69(3):364-7.
1993: Herbert Stöger; MM Wilders-Truschnig; Hellmut Samonigg; M Schmid; Thomas Bauernhofer; Andreas Tiran; M Tas; Hemmo Drexhage
The presence of immunosuppressive 'p15E-like' factors in the serum and urine of patients suffering from malign and benign breast tumours.
Clinical and experimental immunology 1993;93(3):437-41.
1993: P Mooij; Hemmo Drexhage
Autoimmune thyroid disease.
Clinics in laboratory medicine 1993;13(3):683-97.
1993: P Mooij; H J de Wit; A M Bloot; MM Wilders-Truschnig; Hemmo Drexhage
Iodine deficiency induces thyroid autoimmune reactivity in Wistar rats.
Endocrinology 1993;133(3):1197-204.
1993: MM Wilders-Truschnig; H Warnkross; Georg Leb; W Langsteger; O Eber; Andreas Tiran; Harald Dobnig; A Passath; Gerhard Lanzer; Hemmo Drexhage
The effect of treatment with levothyroxine or iodine on thyroid size and thyroid growth stimulating immunoglobulins in endemic goitre patients.
Clinical endocrinology 1993;39(3):281-6.
1993: M P Tas; D Laarman; M D Haan-Meulman; A J Balm; Gordon B Snow; Hemmo Drexhage
Retroviral p15E-related serum factors and recurrence of head and neck cancer.
Clinical otolaryngology and allied sciences 1993;18(4):324-8.
1993: M M van Weissenbruch; H C Schoemaker; Hemmo Drexhage; J Schoemaker
Pharmaco-dynamics of human menopausal gonadotrophin (HMG) and follicle-stimulating hormone (FSH). The importance of the FSH concentration in initiating follicular growth in polycystic ovary-like disease.
Human reproduction (Oxford, England) 1993;8(6):813-21.
1993: M P Tas; P J Simons; F J Balm; Hemmo Drexhage
Depressed monocyte polarization and clustering of dendritic cells in patients with head and neck cancer: in vitro restoration of this immunosuppression by thymic hormones.
Cancer immunology, immunotherapy : CII 1993;36(2):108-14.
1993: Hemmo Drexhage; P Mooy; A Jansen; J Kerrebijn; W Allaerts; M P Tas
Dendritic cells in tumor growth and endocrine diseases.
Advances in experimental medicine and biology 1993;329():643-50.
1993: W Allaerts; P H Jeucken; F T Bosman; Hemmo Drexhage
Relationship between dendritic cells and folliculo-stellate cells in the pituitary: immunohistochemical comparison between mouse, rat and human pituitaries.
Advances in experimental medicine and biology 1993;329():637-42.
1993: P Mooij; M de Haan-Meulman; H J de Wit; Hemmo Drexhage
Thyroid hormones and their iodinated breakdown products enhance the capability of monocytes to mature into veiled cells. Blocking effects of alpha-GM-CSF.
Advances in experimental medicine and biology 1993;329():633-6.
1993: A Hoek; Y van Kasteren; M de Haan-Meulman; Joop Schoemaker; Hemmo Drexhage
A proportion of patients with premature ovarian failure show lowered percentages of blood monocyte derived dendritic cells capable of forming clusters with lymphocytes.
Advances in experimental medicine and biology 1993;329():629-32.
1993: J M van Haarst; H J de Wit; Hemmo Drexhage; Henk C Hoogsteden
Histology and immunophenotype of dendritic cells in the human lung.
Advances in experimental medicine and biology 1993;329():577-80.
1993: A Jansen; H A Voorbij; P H Jeucken; G J Bruining; H Hooijkaas; Hemmo Drexhage
An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreases. A comparison with similar infiltrates found in the pancreas of a diabetic infant.
Autoimmunity 1993;15(1):31-8.
1992: P Mooij; Hemmo Drexhage
Interactions between the immune system and the thyroid. Regulatory networks in health and disease.
Thyroidology / A.P.R.I.M 1992;4(1):45-8.
1991: K Hoekman; B M von Blomberg-van der Flier; John Wagstaff; Hemmo Drexhage; HERBERT PINEDO
Reversible thyroid dysfunction during treatment with GM-CSF.
Lancet 1991;338(8766):541-2.
1991: M Tas; M de Haan-Meulman; P J Kabel; Hemmo Drexhage
Defects in monocyte polarization and dendritic cell clustering in patients with Graves' disease. A putative role for a non-specific immunoregulatory factor related to retroviral p15E.
Clinical endocrinology 1991;34(6):441-8.
1991: W Allaerts; P H Jeucken; Leo Hofland; Hemmo Drexhage
Morphological, immunohistochemical and functional homologies between pituitary folliculo-stellate cells and lymphoid dendritic cells.
Acta endocrinologica 1991;125 Suppl 1():92-7.
1990: H A Voorby; P H Jeucken; Hemmo Drexhage
A delayed-type hypersensitivity skin-test system using the insulinoma cell line RINm5F to monitor beta cell-specific cellular autoimmune reactivity in the spontaneously diabetic BB/O rat.
Clinical and experimental immunology 1990;82(3):542-7.
1990: Hemmo Drexhage; P Mooij; MM Wilders-Truschnig
Thyroid growth stimulating immunoglobulins in sporadic and endemic colloid goitre.
Thyroidology / A.P.R.I.M 1990;2(3):99-105.
1990: A Berghout; Wilmar M Wiersinga; Hemmo Drexhage; NJ Smits; J L Touber
Comparison of placebo with L-thyroxine alone or with carbimazole for treatment of sporadic non-toxic goitre.
Lancet 1990;336(8709):193-7.
1990: M Tas; J A Leezenberg; Hemmo Drexhage
Beneficial effects of the thymic hormone preparation thymostimulin in patients with defects in cell-mediated immunity and chronic purulent rhinosinusitis. A double-blind cross-over trial on improvements in monocyte polarization and clinical effects.
Clinical and experimental immunology 1990;80(3):304-13.
1990: W H Stokvis-Brantsma; M M van Weissenbruch; J M Wit; J Schoemaker; Hemmo Drexhage
Sexual precocity induced by ovarian follicular cysts. Is autoimmunity involved?
Clinical endocrinology 1990;32(5):603-12.
1990: C A Seldenrijk; Hemmo Drexhage; S G Meuwissen; Chris J L M Meijer
T-cellular immune reactions (in macrophage inhibition factor assay) against Mycobacterium paratuberculosis, Mycobacterium kansasii, Mycobacterium tuberculosis, Mycobacterium avium in patients with chronic inflammatory bowel disease.
Gut 1990;31(5):529-35.
1990: H A Voorby; P J Kabel; M de Haan; P H Jeucken; R D van der Gaag; marc de baets; Hemmo Drexhage
Dendritic cells and class II MHC expression on thyrocytes during the autoimmune thyroid disease of the BB rat.
Clinical immunology and immunopathology 1990;55(1):9-22.
1990: MM Wilders-Truschnig; Hemmo Drexhage; Georg Leb; O Eber; Hans-Peter Brezinschek; Gottfried Dohr; Gerhard Lanzer; Günter J Krejs
Chromatographically purified immunoglobulin G of endemic and sporadic goiter patients stimulates FRTL5 cell growth in a mitotic arrest assay.
The Journal of clinical endocrinology and metabolism 1990;70(2):444-52.
1990: I B Tan; Alfons J M Balm; Gordon B Snow; Hemmo Drexhage
Immunosuppressive retroviral-related factors in sera of patients with head and neck cancer.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 1990;247(6):387-90.
1990: M M van Weissenbruch; Hemmo Drexhage; I van Vliet-Bleeker; Joop Schoemaker
Deoxyribonucleic acid cytophometry on rat ovarian follicles kept in organ culture: the effects of gonadotropins and plasma from normal, hypergonadotropic menopausal, and hypogonadotropic women.
The Journal of clinical endocrinology and metabolism 1990;70(1):238-45.
1990: P J Kabel; A van Dinther; M De Haan-Meulman; A Berghout; H A Voorbij; Hemmo Drexhage
A diminished adherence of blood lymphocytes of patients with thyroid autoimmune disease to high endothelial venules in the thyroid and the thyroid-draining lymph nodes.
Autoimmunity 1990;5(4):247-56.
1989: W F Young; J A Carney; B U Musa; N M Wulffraat; J W Lens; Hemmo Drexhage
Familial Cushing's syndrome due to primary pigmented nodular adrenocortical disease. Reinvestigation 50 years later.
The New England journal of medicine 1989;321(24):1659-64.
1989: H A Voorbij; P H Jeucken; P J Kabel; M De Haan; Hemmo Drexhage
Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB rats.
Diabetes 1989;38(12):1623-9.
1989: P van Trotsenburg; Thomas Vulsma; A M Bloot; R D Van der Gaag; J W Lens; Hemmo Drexhage; Jan J M de Vijlder
Antibodies to 'second colloid antigen.' A study on the prevalence in sporadic forms of congenital hypothyroidism.
Acta endocrinologica 1989;121(5):659-65.
1989: H Carstensen; S Krabbe; N M Wulffraat; M D Nielsen; Elisabeth Ralfkiaer; Hemmo Drexhage
Autoimmune involvement in Cushing syndrome due to primary adrenocortical nodular dysplasia.
European journal of pediatrics 1989;149(2):84-7.
1989: P J Kabel; M de Haan-Meulman; H A Voorbij; M Kleingeld; E F Knol; Hemmo Drexhage
Accessory cells with a morphology and marker pattern of dendritic cells can be obtained from elutriator-purified blood monocyte fractions. An enhancing effect of metrizamide in this differentiation.
Immunobiology 1989;179(4-5):395-41.
1989: Steven Boyages; A M Bloot; Glen F Maberly; Creswell Eastman; M Li; Q D Qian; D R Liu; R D van der Gaag; Hemmo Drexhage
Thyroid autoimmunity in endemic goitre caused by excessive iodine intake.
Clinical endocrinology 1989;31(4):453-65.
1989: Steven Boyages; J P Halpern; Glen F Maberly; Creswell Eastman; J Chen; Z H Wang; R D van der Gaag; Hemmo Drexhage
Endemic cretinism: possible role for thyroid autoimmunity.
Lancet 1989;2(8662):529-32.
1989: F Teding van Berkhout; R J Croughs; N M Wulffraat; Hemmo Drexhage
Familial Cushing's syndrome due to nodular adrenocortical dysplasia is an inherited disease of immunological origin.
Clinical endocrinology 1989;31(2):185-91.
1989: A Berghout; Wilmar M Wiersinga; Hemmo Drexhage; P van Trotsenburg; NJ Smits; Ruth van der Gaag; J L Touber
The long-term outcome of thyroidectomy for sporadic non-toxic goitre.
Clinical endocrinology 1989;31(2):193-9.
1989: N M Wulffraat; Hemmo Drexhage; G F Bottazzo; W M Wiersinga; P Jeucken; R Van der Gaag
Immunoglobulins of patients with idiopathic Addison's disease block the in vitro action of adrenocorticotropin.
The Journal of clinical endocrinology and metabolism 1989;69(2):231-8.
1989: MM Wilders-Truschnig; P J Kabel; Hemmo Drexhage; Alfred Beham; Georg Leb; O Eber; J Hebenstreit; D Loidolt; Gottfried Dohr; Gerhard Lanzer
Intrathyroidal dendritic cells, epitheloid cells, and giant cells in iodine deficient goiter.
The American journal of pathology 1989;135(1):219-25.
1989: H A Voorby; R D Van der Gaag; P H Jeucken; A M Bloot; Hemmo Drexhage
The goitre of the BB/O rat: an animal-model for studying the role of immunoglobulins stimulating growth of thyroid cells.
Clinical and experimental immunology 1989;76(2):290-5.
1989: C A Seldenrijk; Hemmo Drexhage; S G Meuwissen; Steven T Pals; Chris J L M Meijer
Dendritic cells and scavenger macrophages in chronic inflammatory bowel disease.
Gut 1989;30(4):484-91.
1989: P J Kabel; H A Voorbij; M de Haan-Meulman; Steven T Pals; Hemmo Drexhage
High endothelial venules present in lymphoid cell accumulations in thyroids affected by autoimmune disease: a study in men and BB rats of functional activity and development.
The Journal of clinical endocrinology and metabolism 1989;68(4):744-51.
1989: M H Mignot; Hemmo Drexhage; M Kleingeld; E M Van de Plassche-Boers; B R Rao; Joop Schoemaker
Premature ovarian failure. II: Considerations of cellular immunity defects.
European journal of obstetrics, gynecology, and reproductive biology 1989;30(1):67-72.
1989: M H Mignot; Joop Schoemaker; M Kleingeld; B R Rao; Hemmo Drexhage
Premature ovarian failure. I: The association with autoimmunity.
European journal of obstetrics, gynecology, and reproductive biology 1989;30(1):59-66.
1988: S van der Baan; C A Seldenrijk; S C Henzen-Logmans; Hemmo Drexhage
Serous otitis media and immunological reactions in the middle ear mucosa.
Acta oto-laryngologica 1988;106(5-6):428-34.
1988: E M van de Plassche-Boers; M Tas; M de Haan-Meulman; M Kleingeld; Hemmo Drexhage
Abnormal monocyte chemotaxis in patients with chronic purulent rhinosinusitis: an effect of retroviral p15E-related factors in serum.
Clinical and experimental immunology 1988;73(3):348-54.
1988: N M Wulffraat; Hemmo Drexhage; W M Wiersinga; R D van der Gaag; P Jeucken; J A Mol
Immunoglobulins of patients with Cushing's syndrome due to pigmented adrenocortical micronodular dysplasia stimulate in vitro steroidogenesis.
The Journal of clinical endocrinology and metabolism 1988;66(2):301-7.
1988: P J Kabel; H A Voorbij; M De Haan; R D van der Gaag; Hemmo Drexhage
Intrathyroidal dendritic cells.
The Journal of clinical endocrinology and metabolism 1988;66(1):199-207.
1988: M Tas; Hemmo Drexhage; J Goudsmit
A monocyte chemotaxis inhibiting factor in serum of HIV infected men shares epitopes with the HIV transmembrane protein gp41.
Clinical and experimental immunology 1988;71(1):13-8.
1987: N M Wulffraat; Hemmo Drexhage; P Jeucken; R D van der Gaag; W M Wiersinga
Effects of ACTH and ACTH fragments on DNA synthesis in guinea-pig adrenal segments kept in organ culture.
The Journal of endocrinology 1987;115(3):505-10.
1987: N de Vries; Hemmo Drexhage; L P de Waal; G de Lange; G B Snow
Human leukocyte antigens and immunoglobulin allotypes in head and neck cancer patients with and without multiple primary tumors.
Cancer 1987;60(5):957-61.
1987: N de Vries; G de Lange; Hemmo Drexhage; G B Snow
Immunoglobulin allotypes in head and neck cancer patients with multiple primary cancers.
Acta oto-laryngologica 1987;104(1-2):187-91.
1987: H Bliddal; L Hegedüs; J M Hansen; K Bech; R van der Gaag; Hemmo Drexhage
The relationships between serum T3 index, thyroid volume, and thyroid stimulating, TSH receptor binding and thyroid growth stimulating antibodies in untreated Graves' disease.
Clinical endocrinology 1987;27(1):75-84.
1987: I B Tan; Hemmo Drexhage; R J Scheper; B M von Blomberg-van de Flier; M dP6Haan-Meulman; G B Snow; F J Balm
Effect of P15E related retroviral material isolated from head and neck carcinomas on delayed type hypersensitivity skin reactions in mice.
The Laryngoscope 1987;97(6):710-2.
1987: I B Tan; Hemmo Drexhage; R Mullink; S Hensen-Logmans; M De Haan-Meulman; G B Snow; A J Balm
Immunohistochemical detection of retroviral-P15E-related material in carcinomas of the head and neck.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 1987;96(3):251-5.
1987: P J Kabel; H A Voorbij; R D van der Gaag; W M Wiersinga; M de Haan; Hemmo Drexhage
Dendritic cells in autoimmune thyroid disease.
Acta endocrinologica. Supplementum 1987;281():42-8.
1986: E M van de Plassche-Boers; Hemmo Drexhage; M Kokjé-Kleingeld; H A Leezenberg
Parameters of T cell mediated immunity to commensal micro-organisms in patients with chronic purulent rhinosinusitis: a comparison between delayed type hypersensitivity skin test, lymphocyte transformation test and macrophage migration inhibition factor assay.
Clinical and experimental immunology 1986;66(3):516-24.
1986: I B Tan; Hemmo Drexhage; R J Scheper; B M von Blomberg-van de Flier; M de Haan-Meulman; G B Snow; F J Balm
Immunosuppressive retroviral P15E-related factors in head and neck carcinomas.
Archives of otolaryngology--head & neck surgery 1986;112(9):942-5.
1986: I B Tan; Hemmo Drexhage; R J Scheper; B M von Blomberg-van der Flier; M de Haan-Meulman; G B Snow; A J Balm
Defective monocyte chemotaxis in patients with head and neck cancer. Restoration after treatment.
Archives of otolaryngology--head & neck surgery 1986;112(5):541-4.
1986: R D van der Gaag; M von Blomberg-van der Flier; E van de Plassche-Boers; M Kokjé-Kleingeld; Hemmo Drexhage
T-suppressor cell defects in euthyroid nonendemic goitre.
Acta endocrinologica 1986;112(1):83-8.
1986: F Teding van Berkhout; R J Croughs; L Kater; H J Schuurman; F J Gmelig Meyling; C D Kooyman; R D van der Gaag; D Jolink; Hemmo Drexhage
Familial Cushing's syndrome due to nodular adrenocortical dysplasia. A putative receptor-antibody disease?
Clinical endocrinology 1986;24(3):299-310.
1986: R D van der Gaag; H Frisch; M Weissel; G Wick; Hemmo Drexhage
Congenital hypothyroidism in a Turkish family: the role of immunoglobulins blocking the trophic effects of TSH and maternal-foetal relationship.
Acta endocrinologica 1986;111(1):44-53.
1985: E M Van de Plassche-Boers; Hemmo Drexhage; M Kokjé-Kleingeld
The use of somatic antigen of Haemophilus influenzae for the monitoring of T cell-mediated skin test reactivity in man.
Journal of immunological methods 1985;83(2):353-61.
1985: R D van der Gaag; Hemmo Drexhage; W M Wiersinga; R S Brown; R Docter; G F Bottazzo; D Doniach
Further studies on thyroid growth-stimulating immunoglobulins in euthyroid nonendemic goiter.
The Journal of clinical endocrinology and metabolism 1985;60(5):972-9.
1985: P M Bell; D G Sinnamon; P P Smyth; Hemmo Drexhage; M Haire; G F Bottazzo; A B Atkinson
Hyperthyroidism following primary hypothyroidism in association with polyendocrine autoimmunity.
Acta endocrinologica 1985;108(4):491-7.
1985: R D van der Gaag; Hemmo Drexhage; J H Dussault
Role of maternal immunoglobulins blocking TSH-induced thyroid growth in sporadic forms of congenital hypothyroidism.
Lancet 1985;1(8423):246-50.
1985: M M Wilders; Hemmo Drexhage; T Sminia; H Mullink; E F Weltevreden; B E Plesh; S G Meuwissen
Veiled cells in the gastrointestinal tract.
Acta chirurgica Scandinavica. Supplementum 1985;525():93-111.
1985: M H Mignot; J W Lens; H Mullink; J G Stolk; J Oort; Hemmo Drexhage
The involvement of dendritic cells in the handling of the immune stimulant C. parvum. A morphological investigation using immunoperoxidase techniques.
Virchows Archiv. B, Cell pathology including molecular pathology 1985;48(4):317-24.
1984: A A Bom-van Noorloos; J J Visser; Hemmo Drexhage; S Meijer; H F Hoitsma
Liver allograft rejection in pigs: histology of the graft and role of swine leukocyte antigen-D.
The Journal of surgical research 1984;37(4):269-76.
1984: D Jolink; Hemmo Drexhage; R D van der Gaag
In vitro trophic effects of synthetic ACTH1-24.
Cell biochemistry and function 1984;2(4):221-4.
1984: F A Balm; Hemmo Drexhage; M von Blomberg; E F Weltevreden; R W Veldhuizen; R Mullink; G B Snow
Mononuclear phagocyte function in head and neck cancer. Chemotactic responsiveness of blood monocytes in correlation between histologic grade of the tumor and infiltration of these cells into the tumor area.
Cancer 1984;54(6):1010-5.
1984: H J Moens; W M Wiersinga; Hemmo Drexhage
Association between autoimmune thyroid disease, atopy, and urticaria?
Lancet 1984;2(8402):582-3.
1984: M M Wilders; Hemmo Drexhage; M Kokjé; Hein Verspaget; S G Meuwissen
Peripolesis followed by cytotoxicity in chronic idiopathic inflammatory bowel disease.
Clinical and experimental immunology 1984;57(3):614-20.
1984: F J Balm; B M von Blomberg-van deFlier; Hemmo Drexhage; M de Haan-Meulman; G B Snow
Mononuclear phagocyte function in head and neck cancer: depression of murine macrophage accumulation by low molecular weight factors derived from head and neck carcinomas.
The Laryngoscope 1984;94(2 Pt 1):223-7.
1984: M M Wilders; Hemmo Drexhage; M Kokjé; Hein Verspaget; S G Meuwissen
Veiled cells in chronic idiopathic inflammatory bowel disease.
Clinical and experimental immunology 1984;55(2):377-87.
1984: A A Bom-van Noorloos; J J Visser; Hemmo Drexhage; S Meijer; H F Hoitsma
Cyclosporin A in orthotopic porcine liver transplantation. Long-term survival after short-term treatment.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 1984;16(6):329-35.
1983: Hemmo Drexhage; E M van de Plassche; M Kokjé; H A Leezenberg
Abnormalities in cell-mediated immune functions to Haemophilus influenzae chronic purulent infections of the upper respiratory tract.
Clinical immunology and immunopathology 1983;28(2):218-28.
1983: J W Lens; Hemmo Drexhage; W Benson; B M Balfour
A study of cells present in lymph draining from a contact allergic reaction in pigs sensitized to DNFB.
Immunology 1983;49(3):415-22.
1983: M M Wilders; Hemmo Drexhage; E F Weltevreden; H Mullink; A Duijvestijn; S G Meuwissen
Large mononuclear Ia-positive veiled cells in Peyer's patches. I. Isolation and characterization in rat, guinea-pig and pig.
Immunology 1983;48(3):453-60.
1983: M M Wilders; T Sminia; B E Plesch; Hemmo Drexhage; E F Weltevreden; S G Meuwissen
Large mononuclear Ia-positive veiled cells in Peyer's patches. II. Localization in rat Peyer's patches.
Immunology 1983;48(3):461-7.
1982: W M Wiersinga; Hemmo Drexhage
[Recurrent struma in a patient with normal thyroid function].
Nederlands tijdschrift voor geneeskunde 1982;126(48):2177-9.
1982: M H Mignot; J W Lens; J G Stolk; J Oort; R W Veldhuizen; G H Dijkhuizen; Hemmo Drexhage
Morphology of draining lymph nodes after local immune stimulation with C. parvum: comparison of pelvic nodes in carcinoma of cervix and popliteal and inguinal nodes of guinea-pig.
British journal of cancer 1982;46(2):198-207.
1982: F J Balm; Hemmo Drexhage; M E von Blomberg; G B Snow
Mononuclear phagocyte function in head and neck cancer: NBT-dye reduction, maturation and migration of peripheral blood monocytes.
The Laryngoscope 1982;92(7 Pt 1):810-4.
1982: Hemmo Drexhage; L J Hammond; L Bitensky; J Chayen; G F Bottazzo; D Doniach
The involvement of the pentose shunt in thyroid metabolism after stimulation with TSH or with immunoglobulins from patients with thyroid disease. II. The reoxidation of NADPH and stimulation of hormone synthesis.
Clinical endocrinology 1982;16(1):57-63.
1982: Hemmo Drexhage; L J Hammond; L Bitensky; J Chayen; G F Bottazzo; D Doniach
The involvement of the pentose shunt in thyroid metabolism after stimulation with TSH or with immunoglobulins from patients with thyroid disease. 1. The generation of NADPH in relation to stimulation of thyroid growth.
Clinical endocrinology 1982;16(1):49-56.
1982: G F Bottazzo; Hemmo Drexhage; E L Khoury
Thyroid antibodies in thyroid diseases.
Ciba Foundation symposium 1982;(90):153-77.
1981: M H Mignot; J W Lens; Hemmo Drexhage; B M von Blomberg; V D Flier; J Oort; J G Stolk
Lower relapse rates after neighbourhood injection of Corynebacterium parvum in operable cervix carcinoma.
British journal of cancer 1981;44(6):856-62.
1981: Hemmo Drexhage; G F Bottazzo; L Bitensky; J Chayen; D Doniach
Thyroid growth-blocking antibodies in primary myxoedema.
Nature 1981;289(5798):594-6.
1981: B M Balfour; Hemmo Drexhage; E W A Kamperdijk; Elisabeth Hoefsmit
Antigen-presenting cells, including Langerhans cells, veiled cells and interdigitating cells.
Ciba Foundation symposium 1981;84():281-301.
1980: B M von Blomberg; J Glerum; J J Croles; J Stam; Hemmo Drexhage
Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus.
British journal of cancer 1980;41(4):609-17.
1980: Hemmo Drexhage; B M Blomberg-vd Flier; W B vd Berg
Studies on the effect of mycobacterial antibodies on skin-test reactivity to M. tuberculosis.
British journal of experimental pathology 1980;61(2):186-94.
1979: Hemmo Drexhage; H Mullink; J de Groot; J Clarke; B M Balfour
A study of cells present in peripheral lymph of pigs with special reference to a type of cell resembling the Langerhans cell.
Cell and tissue research 1979;202(3):407-30.
1979: H Mullink; M Von Blomberg; M M Wilders; Hemmo Drexhage; C L Alons
A simple cytochemical method for distinguishing EAC rosettes formed by lymphocytes and monocytes.
Journal of immunological methods 1979;29(2):133-7.
1978: Hemmo Drexhage; R J Scheper; J Oort
Type-III allergic reactivity to Diplococcus pneumoniae and encapsulated Haemophilus influenzae in passively sensitized mice and rats.
Medical microbiology and immunology 1978;165(1):57-65.
1978: Hemmo Drexhage; R D van der Gaag; F Namavar
Nitroblue tetrazolium-dye reduction by rat peritoneal macrophages during the uptake of Diplococcus pneumoniae, type VI.
Antonie van Leeuwenhoek 1978;44(3-4):377-89.
1977: Hemmo Drexhage; J Oort
Skin test reactivity to H. influenzae antigens as an outcome of the antigen structure and the balance between humoral and cell-mediated immunity in rats.
Clinical and experimental immunology 1977;28(2):280-8.