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Toshiyuki Yoneda

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Masahiro Saito; Eisaku Nishida; Takashi Sasaki; Toshiyuki Yoneda; Nobuyoshi Shimizu
The KK-Periome database for transcripts of periodontal ligament development.
Takuma Matsubara; Kumiko Kida; Akira Yamaguchi; Kenji Hata; Fumitaka Ichida; Hiroko Meguro; Hiroyuki Aburatani; Riko Nishimura; Toshiyuki Yoneda
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.
Katsuhiko Amano; Fumitaka Ichida; Atsushi Sugita; Kenji Hata; Masahiro Wada; Yoko Takigawa; Masako Nakanishi; Mikihiko Kogo; Riko Nishimura; Toshiyuki Yoneda
MSX2 stimulates chondrocyte maturation by controlling Ihh expression.

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All Publications

2009: Masahiro Saito; Eisaku Nishida; Takashi Sasaki; Toshiyuki Yoneda; Nobuyoshi Shimizu
The KK-Periome database for transcripts of periodontal ligament development.
Journal of experimental zoology. Part B, Molecular and developmental evolution 2009;312B(5):495-502.
2008: Takuma Matsubara; Kumiko Kida; Akira Yamaguchi; Kenji Hata; Fumitaka Ichida; Hiroko Meguro; Hiroyuki Aburatani; Riko Nishimura; Toshiyuki Yoneda
BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation.
The Journal of biological chemistry 2008;283(43):29119-25.
2008: Katsuhiko Amano; Fumitaka Ichida; Atsushi Sugita; Kenji Hata; Masahiro Wada; Yoko Takigawa; Masako Nakanishi; Mikihiko Kogo; Riko Nishimura; Toshiyuki Yoneda
MSX2 stimulates chondrocyte maturation by controlling Ihh expression.
The Journal of biological chemistry 2008;283(43):29513-21.
2008: Kenji Hata; Riko Nishimura; Shuji Muramatsu; Akio Matsuda; Takuma Matsubara; Katsuhiko Amano; Fumiyo Ikeda; Vincent R Harley; Toshiyuki Yoneda
Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.
The Journal of clinical investigation 2008;118(9):3098-108.
2008: Guojun Bu; Wenyan Lu; Chia-Chen Liu; Katri Selander; Toshiyuki Yoneda; Christopher L Hall; Evan T Keller; Yonghe Li
Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.
International journal of cancer. Journal international du cancer 2008;123(5):1034-42.
2008: Daisuke Tamura; Toru Hiraga; Akira Myoui; Hideki Yoshikawa; Toshiyuki Yoneda
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone.
International journal of oncology 2008;33(1):17-24.
2008: D Oxmann; Janka Held-Feindt; Andreas M Stark; K Hattermann; Toshiyuki Yoneda; Rolf Mentlein
Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype.
Oncogene 2008;27(25):3567-75.
2008: Fumiyo Ikeda; Takuma Matsubara; Taro Tsurukai; Kenji Hata; Riko Nishimura; Toshiyuki Yoneda
JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(6):907-14.
2008: Hiroaki Nakamura; Toru Hiraga; Tadashi Ninomiya; Akihiro Hosoya; Noboru Fujisaki; Toshiyuki Yoneda; Hidehiro Ozawa
Involvement of cell-cell and cell-matrix interactions in bone destruction induced by metastatic MDA-MB-231 human breast cancer cells in nude mice.
Journal of bone and mineral metabolism 2008;26(6):642-7.
2008: Riko Nishimura; Kenji Hata; Fumiyo Ikeda; Fumitaka Ichida; Atsuko Shimoyama; Takuma Matsubara; Masahiro Wada; Katsuhiko Amano; Toshiyuki Yoneda
Signal transduction and transcriptional regulation during mesenchymal cell differentiation.
Journal of bone and mineral metabolism 2008;26(3):203-12.
2008: J Zhang; J Zhu; Paloma Valverde; L Li; S Pageau; Qisheng Tu; R Nishimura; Toshiyuki Yoneda; P Yang; W Zheng; W Ma; J Chen
Phenotypic analysis of Dlx5 overexpression in post-natal bone.
Journal of dental research 2008;87(1):45-50.
2007: Bernd Schmid; Günther A Rezniczek; Gerhild Fabjani; Toshiyuki Yoneda; Sepp Leodolter; Robert Zeillinger
The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells.
Breast cancer research and treatment 2007;106(3):333-42.
2007: Masahiro Wada; Atsuko Shimoyama; Riko Nishimura; Toshiyuki Yoneda
[Role of Gli family members in Indian hedgehog-induced osteoblast differentiation].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 9():75-80.
2007: Shuji Muramatsu; Makoto Wakabayashi; Takeshi Ohno; Katsuhiko Amano; Rika Ooishi; Toshinori Sugahara; Satoshi Shiojiri; Kosuke Tashiro; Yutaka Suzuki; Riko Nishimura; Satoru Kuhara; Sumio Sugano; Toshiyuki Yoneda; Akio Matsuda
Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.
The Journal of biological chemistry 2007;282(44):32158-67.
2007: Tetsuyuki Hayashibara; Toru Hiraga; Atsushi Sugita; Liyang Wang; Kenji Hata; Takashi Ooshima; Toshiyuki Yoneda
Regulation of osteoclast differentiation and function by phosphate: potential role of osteoclasts in the skeletal abnormalities in hypophosphatemic conditions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(11):1743-51.
2007: Atsuko Shimoyama; Masahiro Wada; Fumiyo Ikeda; Kenji Hata; Takuma Matsubara; Akira Nifuji; Masaki Noda; Katsuhiko Amano; Akira Yamaguchi; Riko Nishimura; Toshiyuki Yoneda
Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function.
Molecular biology of the cell 2007;18(7):2411-8.
2007: Diane Palmieri; Julie L Bronder; Jeanne M Herring; Toshiyuki Yoneda; Robert J Weil; Andreas M Stark; Raffael Kurek; Eleazar Vega-Valle; Lionel Feigenbaum; Douglas Halverson; Alexander O Vortmeyer; Seth M Steinberg; Kenneth Aldape; Patricia S Steeg
Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain.
Cancer research 2007;67(9):4190-8.
2007: Toru Hiraga; Shinae Kizaka-Kondoh; Kiichi Hirota; Masahiro Hiraoka; Toshiyuki Yoneda
Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.
Cancer research 2007;67(9):4157-63.
2007: Karen Block; Yves Gorin; Paul Hoover; Paul Williams; Tomasz Chelmicki; Robert Clark; Toshiyuki Yoneda; Hanna Abboud
NAD(P)H oxidases regulate HIF-2alpha protein expression.
The Journal of biological chemistry 2007;282(11):8019-26.
2007: Riko Nishimura; Kenji Hata; Toshiyuki Yoneda
[Relationship between bone metabolism and adipogenesis].
Clinical calcium 2007;17(2):233-40.
2007: Maho Nagae; Toru Hiraga; Toshiyuki Yoneda
Acidic microenvironment created by osteoclasts causes bone pain associated with tumor colonization.
Journal of bone and mineral metabolism 2007;25(2):99-104.
2007: Andreas M Stark; Bartosz Anuszkiewicz; Rolf Mentlein; Toshiyuki Yoneda; H Maximilian Mehdorn; Janka Held-Feindt
Differential expression of matrix metalloproteinases in brain- and bone-seeking clones of metastatic MDA-MB-231 breast cancer cells.
Journal of neuro-oncology 2007;81(1):39-48.
2006: Hiroaki Ohno; Kazuo Kubo; Hideko Murooka; Yoshiko Kobayashi; Tsuyoshi Nishitoba; Masabumi Shibuya; Toshiyuki Yoneda; Toshiyuki Isoe
A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model.
Molecular cancer therapeutics 2006;5(11):2634-43.
2006: Chris Heyn; John A Ronald; Soha S Ramadan; Jonatan A Snir; Andrea M Barry; Lisa T MacKenzie; David J Mikulis; Diane Palmieri; Julie L Bronder; Patricia S Steeg; Toshiyuki Yoneda; Ian C MacDonald; Ann F Chambers; Brian K Rutt; Paula J Foster
In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(5):1001-10.
2006: Maho Nagae; Toru Hiraga; Hiroki Wakabayashi; Liyang Wang; Koichi Iwata; Toshiyuki Yoneda
Osteoclasts play a part in pain due to the inflammation adjacent to bone.
Bone 2006;39(5):1107-15.
2006: Atsushi Sugita; Tetsuyuki Hayashibara; Toshiyuki Yoneda
[Role of the type 3 sodium-dependent phosphate transporter in the calcification of growth plate chondrocytes].
Clinical calcium 2006;16(10):1723-29.
2006: Fumiyo Ikeda; Riko Nishimura; Takuma Matsubara; Kenji Hata; Sakamuri V Reddy; Toshiyuki Yoneda
Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2384-90.
2006: Riko Nishimura; Toshiyuki Yoneda
[Role of Wnt in bone formation].
Clinical calcium 2006;16(5):817-22.
2006: Emma T Bowden; Ena Onikoyi; Rebecca Slack; Akira Myoui; Toshiyuki Yoneda; Kenneth M Yamada; Susette C Mueller
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells.
Experimental cell research 2006;312(8):1240-53.
2006: Hiroki Wakabayashi; Toru Hiraga; Toshiyuki Yoneda
[Mechanism of cancer-induced bone pain].
Clinical calcium 2006;16(4):605- 11.
2006: Toshiyuki Yoneda
[Pathophysiology of osteolytic bone metastasis associated with solid cancers].
Clinical calcium 2006;16(4):548- 56.
2006: Toru Hiraga; Akira Myoui; Mary E Choi; Hideki Yoshikawa; Toshiyuki Yoneda
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer.
Cancer research 2006;66(4):2067-73.
2006: Takuma Matsubara; Akira Myoui; Fumiyo Ikeda; Kenji Hata; Hideki Yoshikawa; Riko Nishimura; Toshiyuki Yoneda
Critical role of cortactin in actin ring formation and osteoclastic bone resorption.
Journal of bone and mineral metabolism 2006;24(5):368-72.
2005: Toru Hiraga; Kenji Hata; Fumiyo Ikeda; Jirouta Kitagaki; Kaori Fujimoto-Ouchi; Yutaka Tanaka; Toshiyuki Yoneda
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
Oncology reports 2005;14(3):695-9.
2005: Toshiyuki Yoneda
[Mechanism and treatment of cancer metastasis to bone].
Clinical calcium 2005;15(7):29-37.
2005: Toshiyuki Yoneda; Toru Hiraga
Crosstalk between cancer cells and bone microenvironment in bone metastasis.
Biochemical and biophysical research communications 2005;328(3):679-87.
2005: Kenji Hata; Riko Nishimura; Mio Ueda; Fumiyo Ikeda; Takuma Matsubara; Fumitaka Ichida; Kunihiro Hisada; Takashi Nokubi; Akira Yamaguchi; Toshiyuki Yoneda
A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes.
Molecular and cellular biology 2005;25(5):1971-9.
2005: Yasushi Kitagawa; Toru Hiraga; Yoshiaki Yura; Toshiyuki Yoneda
Suppression by incadronate of invasion and growth of A-375 human melanoma in mandible in nude mice.
Oncology reports 2005;13(2):211-6.
2004: Yoshihisa Mori; Nobuaki Shimizu; Mark Dallas; Maryla Niewolna; Beryl Story; Paul J Williams; Gregory R Mundy; Toshiyuki Yoneda
Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis.
Blood 2004;104(7):2149-54.
2004: Fumitaka Ichida; Riko Nishimura; Kenji Hata; Takuma Matsubara; Fumiyo Ikeda; Kunihiro Hisada; Hirofumi Yatani; Xu Cao; Toshihisa Komori; Akira Yamaguchi; Toshiyuki Yoneda
Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation.
The Journal of biological chemistry 2004;279(32):34015-22.
2004: Fumiyo Ikeda; Riko Nishimura; Takuma Matsubara; Sakae Tanaka; Jun-ichiro Inoue; Sakamuri V Reddy; Kenji Hata; Kenji Yamashita; Toru Hiraga; Toshiyuki Watanabe; Toshio Kukita; Katsuji Yoshioka; Anjana Rao; Toshiyuki Yoneda
Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation.
The Journal of clinical investigation 2004;114(4):475-84.
2004: Toru Hiraga; Paul J Williams; Akimi Ueda; Daisuke Tamura; Toshiyuki Yoneda
Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(13):4559-67.
2004: J H Zhang; J Wang; J Tang; B Barnett; J Dickson; N Hahsimoto; P Williams; W Ma; W Zheng; Toshiyuki Yoneda; S Pageau; J Chen
Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells.
Anticancer research 2004;24(3a):1361-8.
2004: Akio Hiraki; Hiroshi Ueoka; Ichiro Takata; Kenichi Gemba; Akihiro Bessho; Yoshihiko Segawa; Katsuyuki Kiura; Kenji Eguchi; Toshiyuki Yoneda; Mitsune Tanimoto; Mine Harada
Hypercalcemia-leukocytosis syndrome associated with lung cancer.
Lung cancer (Amsterdam, Netherlands) 2004;43(3):301-7.
2004: Tetsuyuki Hayashibara; Toru Hiraga; Bing Yi; Motoyoshi Nomizu; Yoshinari Kumagai; Riko Nishimura; Toshiyuki Yoneda
A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(3):455-62.
2004: Toshiyuki Yoneda; Nobuyuki Hashimoto; Toru Hiraga
Bisphosphonate actions on bone and visceral metastases.
Cancer treatment and research 2004;118():213-29.
2003: Toru Hiraga; Akimi Ueda; Daisuke Tamura; Kenji Hata; Fumiyo Ikeda; Paul J Williams; Toshiyuki Yoneda
Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer.
International journal of cancer. Journal international du cancer 2003;106(6):973-9.
2003: Jian-Hua Zhang; Jean Tang; Jie Wang; Wenli Ma; Wenling Zheng; Toshiyuki Yoneda; Jake Chen
Over-expression of bone sialoprotein enhances bone metastasis of human breast cancer cells in a mouse model.
International journal of oncology 2003;23(4):1043-8.
2003: Toshiyuki Yoneda; N Hashimoto; T Hiraga
Bisphosphonate actions on cancer.
Calcified tissue international 2003;73(4):315-8.
2003: Akira Myoui; Riko Nishimura; Paul J Williams; Toru Hiraga; Daisuke Tamura; Toshimi Michigami; Gregory R Mundy; Toshiyuki Yoneda
C-SRC tyrosine kinase activity is associated with tumor colonization in bone and lung in an animal model of human breast cancer metastasis.
Cancer research 2003;63(16):5028-33.
2003: Shinichiro Mine; Takeshi Fujisaki; Chie Kawahara; Takahiro Tabata; Takeshi Iida; Manabu Yasuda; Toshiyuki Yoneda; Yoshiya Tanaka
Hepatocyte growth factor enhances adhesion of breast cancer cells to endothelial cells in vitro through up-regulation of CD44.
Experimental cell research 2003;288(1):189-97.
2003: Riko Nishimura; Kenji Hata; Fumiyo Ikeda; Takuma Matsubara; Kenji Yamashita; Fumitaka Ichida; Toshiyuki Yoneda
The role of Smads in BMP signaling.
Frontiers in bioscience : a journal and virtual library 2003;8():s275-84.
2003: Kenji Hata; Riko Nishimura; Fumiyo Ikeda; Kenji Yamashita; Takuma Matsubara; Takashi Nokubi; Toshiyuki Yoneda
Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis.
Molecular biology of the cell 2003;14(2):545-55.
2003: J Chen; J A Rodriguez; B Barnett; N Hashimoto; J Tang; Toshiyuki Yoneda
Bone sialoprotein promotes tumor cell migration in both in vitro and in vivo models.
Connective tissue research 2003;44 Suppl 1():279-84.
2002: Motomi Enomoto-Iwamoto; Jirouta Kitagaki; Eiki Koyama; Yoshihiro Tamamura; Changshan Wu; Naoko Kanatani; Tatsuya Koike; Hiroshi Okada; Toshihisa Komori; Toshiyuki Yoneda; Vicki Church; Philippa Francis-West; Kojiro Kurisu; Tsutomu Nohno; Maurizio Pacifici; Masahiro Iwamoto
The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis.
Developmental biology 2002;251(1):142-56.
2002: Akio Hiraki; Hiroshi Ueoka; Akihiro Bessho; Yoshihiko Segawa; Nagio Takigawa; Katsuyuki Kiura; Kenji Eguchi; Toshiyuki Yoneda; Mitsune Tanimoto; Mine Harada
Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia.
Cancer 2002;95(8):1706-13.
2002: Fei Wang; Rhonda K Hansen; Derek Radisky; Toshiyuki Yoneda; Mary Helen Barcellos-Hoff; Ole W Petersen; Eva A Turley; Mina J Bissell
Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts.
Journal of the National Cancer Institute 2002;94(19):1494-503.
2002: Toshimi Michigami; Toru Hiraga; Paul J Williams; Maryla Niewolna; Riko Nishimura; Gregory R Mundy; Toshiyuki Yoneda
The effect of the bisphosphonate ibandronate on breast cancer metastasis to visceral organs.
Breast cancer research and treatment 2002;75(3):249-58.
2002: Riko Nishimura; Kenji Hata; Stephen E Harris; Fumiyo Ikeda; Toshiyuki Yoneda
Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5.
Bone 2002;31(2):303-12.
2002: Toshiyuki Yoneda
[Role of cell adhesion molecules in bone metastasis].
Clinical calcium 2002;12(5):620-5.
2002: Teruo Iwasaki; Kunihiro Yamashita; Tohru Tsujimura; Shin-ichiro Kashiwamura; Hiroko Tsutsui; Tsuneyasu Kaisho; Ayako Sugihara; Naoko Yamada; Mutsuko Mukai; Toshiyuki Yoneda; Haruki Okamura; Hitoshi Akedo; Nobuyuki Terada
Interleukin-18 inhibits osteolytic bone metastasis by human lung cancer cells possibly through suppression of osteoclastic bone-resorption in nude mice.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2002;25 Suppl 1():S52-60.
2002: Toshiyuki Yoneda
[Stimulation of bone formation by anti-hyperlipidemic agent statins and its mechanism of action].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 3():688-95.
2002: Bing Yi; Paul J Williams; Maryla Niewolna; Yakun Wang; Toshiyuki Yoneda
Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer.
Cancer research 2002;62(3):917-23.
2001: James G Jackson; X Zhang; Toshiyuki Yoneda; D Yee
Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines.
Oncogene 2001;20(50):7318-25.
2001: Toshiyuki Yoneda; Paul J Williams; Toru Hiraga; Maryla Niewolna; Riko Nishimura
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001;16(8):1486-95.
2001: Toru Hiraga; Paul J Williams; Gregory R Mundy; Toshiyuki Yoneda
The bisphosphonate ibandronate promotes apoptosis in MDA-MB-231 human breast cancer cells in bone metastases.
Cancer research 2001;61(11):4418-24.
2001: Gregory R Mundy; Toshiyuki Yoneda; T Hiraga
Preclinical studies with zoledronic acid and other bisphosphonates: impact on the bone microenvironment.
Seminars in oncology 2001;28(2 Suppl 6):35-44.
2001: J C Cruz; M Alsina; F Craig; Toshiyuki Yoneda; J L Anderson; Mari Hashitate Dallas; David G Roodman
Ibandronate decreases bone disease development and osteoclast stimulatory activity in an in vivo model of human myeloma.
Experimental hematology 2001;29(4):441-7.
2001: Babatunde Oyajobi; D M Anderson; K Traianedes; Paul J Williams; Toshiyuki Yoneda; Gregory R Mundy
Therapeutic efficacy of a soluble receptor activator of nuclear factor kappaB-IgG Fc fusion protein in suppressing bone resorption and hypercalcemia in a model of humoral hypercalcemia of malignancy.
Cancer research 2001;61(6):2572-8.
2001: Toshiyuki Yoneda
[Future directions of molecular bone cell biology].
Clinical calcium 2001;11(1):79-86.
2000: M Marzia; Natalie Sims; S Voit; Silvia Migliaccio; Anna Taranta; Silvia Bernardini; Tullio Faraggiana; Toshiyuki Yoneda; G R Mundy; B F Boyce; R Baron; Anna Teti
Decreased c-Src expression enhances osteoblast differentiation and bone formation.
The Journal of cell biology 2000;151(2):311-20.
2000: Toshimi Michigami; N Shimizu; Paul J Williams; Maryla Niewolna; Sarah L Dallas; Gregory R Mundy; Toshiyuki Yoneda
Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity.
Blood 2000;96(5):1953-60.
2000: Toshiyuki Yoneda; Toshimi Michigami; Bing Yi; Paul J Williams; Maryla Niewolna; Toru Hiraga
Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma.
Cancer 2000;88(12 Suppl):2979-88.
2000: James G Jackson; Toshiyuki Yoneda; Gary M Clark; D Yee
Elevated levels of p66 Shc are found in breast cancer cell lines and primary tumors with high metastatic potential.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1135-9.
2000: X Ji; D Chen; C Xu; Stephen E Harris; G R Mundy; Toshiyuki Yoneda
Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A.
Journal of bone and mineral metabolism 2000;18(3):132-9.
2000: Toshiyuki Yoneda
Cellular and molecular basis of preferential metastasis of breast cancer to bone.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2000;5(1):75-81.
1999: Toshiyuki Yoneda; Toshimi Michigami; Bing Yi; Paul J Williams; Maryla Niewolna; Toru Hiraga
Use of bisphosphonates for the treatment of bone metastasis in experimental animal models.
Cancer treatment reviews 1999;25(5):293-9.
1999: BF Boyce; Toshiyuki Yoneda; Theresa A Guise
Factors regulating the growth of metastatic cancer in bone.
Endocrine-related cancer 1999;6(3):333-47.
1998: Sakamuri V Reddy; R Devlin; Cheikh Menaa; R Nishimura; S J Choi; Mark Dallas; Toshiyuki Yoneda; David G Roodman
Isolation and characterization of a cDNA clone encoding a novel peptide (OSF) that enhances osteoclast formation and bone resorption.
Journal of cellular physiology 1998;177(4):636-45.
1998: Toshimi Michigami; M Nomizu; Y Yamada; C Dunstan; Paul J Williams; G R Munday; Toshiyuki Yoneda
Growth and dissemination of a newly-established murine B-cell lymphoma cell line is inhibited by multimeric YIGSR peptide.
Clinical & experimental metastasis 1998;16(7):645-54.
1998: G R Mundy; Toshiyuki Yoneda
Bisphosphonates as anticancer drugs.
The New England journal of medicine 1998;339(6):398-400.
1998: G Mbalaviele; Riko Nishimura; A Myoi; Maryla Niewolna; Sakamuri V Reddy; Di Chen; J Feng; D Roodman; Gregory R Mundy; Toshiyuki Yoneda
Cadherin-6 mediates the heterotypic interactions between the hemopoietic osteoclast cell lineage and stromal cells in a murine model of osteoclast differentiation.
The Journal of cell biology 1998;141(6):1467-76.
1998: Akira Sasaki; Toshiyuki Yoneda; N Terakado; Rafael Alcalde; A Suzuki; Tomohiro Matsumura
Experimental bone metastasis model of the oral and maxillofacial region.
Anticancer research 1998;18(3A):1579-84.
1998: Riko Nishimura; K Moriyama; K Yasukawa; Gregory R Mundy; Toshiyuki Yoneda
Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(5):777-85.
1998: Toshiyuki Yoneda
Cellular and molecular mechanisms of breast and prostate cancer metastasis to bone.
European journal of cancer (Oxford, England : 1990) 1998;34(2):240-5.
1998: Riko Nishimura; Y Kato; Di Chen; Stephen E Harris; Gregory R Mundy; Toshiyuki Yoneda
Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12.
The Journal of biological chemistry 1998;273(4):1872-9.
1997: Toshiyuki Yoneda
Arterial microvascularization and breast cancer colonization in bone.
Histology and histopathology 1997;12(4):1145-9.
1997: Toshiyuki Yoneda; Akira Sasaki; C Dunstan; Paul J Williams; F Bauss; Y A De Clerck; Gregory R Mundy
Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2.
The Journal of clinical investigation 1997;99(10):2509-17.
1996: Theresa A Guise; Juan Juan Yin; S D Taylor; Y Kumagai; Mark Dallas; B F Boyce; Toshiyuki Yoneda; Gregory R Mundy
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.
The Journal of clinical investigation 1996;98(7):1544-9.
1996: Elzbieta Izbicka; Toshiyuki Yoneda; Y Takaoka; D Horn; P Williams; Gregory R Mundy
Identification of a novel bone/calcium metabolism-regulating factor in porcine pancreas.
The Journal of biological chemistry 1996;271(38):23230-4.
1996: G Mbalaviele; C R Dunstan; Akira Sasaki; Paul J Williams; Gregory R Mundy; Toshiyuki Yoneda
E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model.
Cancer research 1996;56(17):4063-70.
1996: K Moriyama; Paul J Williams; M Niewolna; Mark Dallas; Y Uehara; Gregory R Mundy; Toshiyuki Yoneda
Herbimycin A, a tyrosine kinase inhibitor, impairs hypercalcemia associated with a human squamous cancer producing interleukin-6 in nude mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996;11(7):905-11.
1995: David Hughes; Kenneth Wright; H L Uy; Akira Sasaki; Toshiyuki Yoneda; David G Roodman; Gregory R Mundy; B F Boyce
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1995;10(10):1478-87.
1995: Akira Sasaki; B F Boyce; Beryl Story; Kenneth Wright; M Chapman; R Boyce; Gregory R Mundy; Toshiyuki Yoneda
Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice.
Cancer research 1995;55(16):3551-7.
1995: G Mbalaviele; H Chen; B F Boyce; Gregory R Mundy; Toshiyuki Yoneda
The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow.
The Journal of clinical investigation 1995;95(6):2757-65.
1995: Toshiyuki Yoneda; P Williams; C Rhine; B F Boyce; C Dunstan; Gregory R Mundy
Suramin suppresses hypercalcemia and osteoclastic bone resorption in nude mice bearing a human squamous cancer.
Cancer research 1995;55(9):1989-93.
1995: Gregory R Mundy; Toshiyuki Yoneda
Facilitation and suppression of bone metastasis.
Clinical orthopaedics and related research 1995;(312):34-44.
1995: H Kato; R Matsuo; O Komiyama; T Tanaka; M Inazu; H Kitagawa; Toshiyuki Yoneda
Decreased mitogenic and osteogenic responsiveness of calvarial osteoblasts isolated from aged rats to basic fibroblast growth factor.
Gerontology 1995;41 Suppl 1():20-7.
1994: Toshiyuki Yoneda; Y Takaoka; B F Boyce; L Scott; Gregory R Mundy
Extracts of porcine pancreas prevent progression of hypercalcemia and cachexia and prolong survival in nude mice bearing a human squamous carcinoma.
Cancer research 1994;54(9):2509-13.
1994: Toshiyuki Yoneda; A Sasaki; G R Mundy
Osteolytic bone metastasis in breast cancer.
Breast cancer research and treatment 1994;32(1):73-84.
1994: Elzbieta Izbicka; M Niewolna; Toshiyuki Yoneda; C Lowe; B Boyce; Gregory R Mundy
pp60 c-src expression and activity in MG-63 osteoblastic cells modulated by PTH but not required for PTH-mediated adenylate cyclase response.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994;9(1):127-32.
1993: José A Riancho; María T Zarrabeitia; G R Mundy; Toshiyuki Yoneda; Jesús González-Macías
Effects of interleukin-4 on the formation of macrophages and osteoclast-like cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1993;8(11):1337-44.
1993: Toshiyuki Yoneda; I Kato; L F Bonewald; W H Burgess; Gregory R Mundy
A novel cytokine with osteoclastopoietic activity.
Journal of periodontal research 1993;28(6 Pt 2):521-2.
1993: Toshiyuki Yoneda; M Niewolna; C Lowe; Elzbieta Izbicka; Gregory R Mundy
Hormonal regulation of pp60c-src expression during osteoclast formation in vitro.
Molecular endocrinology (Baltimore, Md.) 1993;7(10):1313-8.
1993: J Mihara; Toshiyuki Yoneda; S C Holt
Role of Porphyromonas gingivalis-derived fibroblast-activating factor in bone resorption.
Infection and immunity 1993;61(8):3562-4.
1993: Theresa A Guise; Toshiyuki Yoneda; A J Yates; Gregory R Mundy
The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro.
The Journal of clinical endocrinology and metabolism 1993;77(1):40-5.
1993: Toshiyuki Yoneda; C Lowe; C H Lee; G Gutierrez; M Niewolna; Paul J Williams; Elzbieta Izbicka; Y Uehara; Gregory R Mundy
Herbimycin A, a pp60c-src tyrosine kinase inhibitor, inhibits osteoclastic bone resorption in vitro and hypercalcemia in vivo.
The Journal of clinical investigation 1993;91(6):2791-5.
1993: C Lowe; Toshiyuki Yoneda; B F Boyce; H Chen; Gregory R Mundy; P Soriano
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(10):4485-9.
1993: Toshiyuki Yoneda; M Nakai; K Moriyama; L Scott; N Ida; T Kunitomo; Gregory R Mundy
Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma.
Cancer research 1993;53(4):737-40.
1992: M Nakai; Gregory R Mundy; Paul J Williams; B Boyce; Toshiyuki Yoneda
A synthetic antagonist to laminin inhibits the formation of osteolytic metastases by human melanoma cells in nude mice.
Cancer research 1992;52(19):5395-9.
1992: B F Boyce; Toshiyuki Yoneda; C Lowe; P Soriano; Gregory R Mundy
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice.
The Journal of clinical investigation 1992;90(4):1622-7.
1992: Kaladhar B Reddy; G L Mangold; A K Tandon; Toshiyuki Yoneda; Gregory R Mundy; Asher Zilberstein; C Kent Osborne
Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor.
Cancer research 1992;52(13):3636-41.
1992: Gregory R Mundy; David G Roodman; Lynda F Bonewald; Toshiyuki Yoneda; M Sabatini
Effects of TNF and lymphotoxin on bone cells.
Immunology series 1992;56():483-98.
1991: Toshiyuki Yoneda; R M Lyall; M M Alsina; P E Persons; A P Spada; A Levitzki; Asher Zilberstein; Gregory R Mundy
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.
Cancer research 1991;51(16):4430-5.
1991: Toshiyuki Yoneda; R Nishimura; I Kato; M Ohmae; M Takita; Masayoshi Sakuda
Frequency of the hypercalcemia-leukocytosis syndrome in oral malignancies.
Cancer 1991;68(3):617-22.
1991: Toshiyuki Yoneda; M M Alsina; J L Garcia; Gregory R Mundy
Differentiation of HL-60 cells into cells with the osteoclast phenotype.
Endocrinology 1991;129(2):683-9.
1991: Toshiyuki Yoneda; M M Alsina; K Watatani; F Bellot; J Schlessinger; Gregory R Mundy
Dependence of a human squamous carcinoma and associated paraneoplastic syndromes on the epidermal growth factor receptor pathway in nude mice.
Cancer research 1991;51(9):2438-43.
1991: Toshiyuki Yoneda; T B Aufdemorte; R Nishimura; N Nishikawa; M Sakuda; M M Alsina; J B Chavez; G R Mundy
Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice: a novel experimental model of three concomitant paraneoplastic syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1991;9(3):468-77.
1991: Toshiyuki Yoneda; M A Alsina; J B Chavez; Lynda F Bonewald; R Nishimura; Gregory R Mundy
Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice.
The Journal of clinical investigation 1991;87(3):977-85.
1991: Toshiyuki Yoneda; Y Takaoka; M M Alsina; J Garcia; Gregory R Mundy
Porcine pancreas extract decreases blood-ionized calcium in mice and inhibits osteoclast formation and bone resorption in culture.
FEBS letters 1991;278(2):171-4.
1986: Toshiyuki Yoneda; M Urade; M Sakuda; T Miyazaki
Altered growth, differentiation, and responsiveness to epidermal growth factor of human embryonic mesenchymal cells of palate by persistent rubella virus infection.
The Journal of clinical investigation 1986;77(5):1613-21.
1985: Toshiyuki Yoneda; M Kitamura; T Ogawa; S Aya; M Sakuda
Control of VX2 carcinoma cell growth in culture by calcium, calmodulin, and prostaglandins.
Cancer research 1985;45(1):398-405.
1984: Toshiyuki Yoneda; S Aya; M Sakuda
Sodium butyrate (SB) augments the effects of 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) on neoplastic and osteoblastic phenotype in clonal rat osteosarcoma cells.
Biochemical and biophysical research communications 1984;121(3):796-801.
1982: Toshiyuki Yoneda; R M Pratt
Vitamin B6 reduces cortisone-induced cleft palate in the mouse.
Teratology 1982;26(3):255-8.
1982: Toshiyuki Yoneda; G R Mundy
Release of the lymphokine osteoclast activating factor requires cyclic AMP accumulation.
Calcified tissue international 1982;34(2):204-8.
1981: Toshiyuki Yoneda
[Process and mechanism of absorption and destruction of alveolar bones].
Shikai tenbo = Dental outlook 1981;57(1):91-101.
1979: Toshiyuki Yoneda; G R Mundy
Monocytes regulate osteoclast-activating factor production by releasing prostaglandins.
The Journal of experimental medicine 1979;150(2):338-50.
1979: Toshiyuki Yoneda; G R Mundy
Prostaglandins are necessary for osteoclast-activating factor production by activated peripheral blood leukocytes.
The Journal of experimental medicine 1979;149(1):279-83.

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