FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Holly Van Remmen

Research Profile

Living Beings

Disorders

Chemicals & Drugs

Anatomy

Co-author Network

Publications

TOP 3
Yiqiang Zhang; Hong-Mei Zhang; Alex Bokov; Jonathan Gelfond; Gene Hubbard; Yuji Ikeno; Carlos Jaramillo; Yuhong Liu; Wenbo Qi; Arlan Richardson; Holly Van Remmen
Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.
Sathyaseelan S Deepa; Shauna Hill; Nicolas Musi; Daniel Pulliam; Adam Salmon; Yun Shi; Lauren Sloane; Carlo Viscomi; Michael E Walsh; Massimo Zeviani; Ning Zhang; Holly Van Remmen
Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity.
Yun Shi; Lauren B Sloane; Zoltan Ungvari; Steven Austad; Arunabh Bhattacharya; Rochelle Buffenstein; Asish Chaudhuri; Ryan T Hamilton; Amanda L Jernigan; Yuhong Liu; Daniel A Pulliam; Wenbo Qi; Holly Van Remmen
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Holly Van Remmen (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Yiqiang Zhang; Hong-Mei Zhang; Alex Bokov; Jonathan Gelfond; Gene Hubbard; Yuji Ikeno; Carlos Jaramillo; Yuhong Liu; Wenbo Qi; Arlan Richardson; Holly Van Remmen
Dietary restriction attenuates the accelerated aging phenotype of Sod1(-/-) mice.
Free radical biology & medicine 2013;60():300-6.
2013: Sathyaseelan S Deepa; Shauna Hill; Nicolas Musi; Daniel Pulliam; Adam Salmon; Yun Shi; Lauren Sloane; Carlo Viscomi; Michael E Walsh; Massimo Zeviani; Ning Zhang; Holly Van Remmen
Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(4):1371-80.
2013: Yun Shi; Lauren B Sloane; Zoltan Ungvari; Steven Austad; Arunabh Bhattacharya; Rochelle Buffenstein; Asish Chaudhuri; Ryan T Hamilton; Amanda L Jernigan; Yuhong Liu; Daniel A Pulliam; Wenbo Qi; Holly Van Remmen
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
American journal of physiology. Regulatory, integrative and comparative physiology 2013;304(5):R343-55.
2012: Kavithalakshmi Sataranatarajan; Holly Van Remmen; Hima Bindu Yalamanchili; Jeffrey Barnes; Goutam G Choudhury; Robert T Day; Denis Feliers; Hak Joo Lee; Myung Ja Lee; Meenalakshmi M Mariappan; Arlan G Richardson; Balakuntalam Kasinath
Molecular events in matrix protein metabolism in the aging kidney.
Aging cell 2012;11(6):1065-73.
2012: Young C Jang; Yan Li; Yuhong Liu; Michael S Lustgarten; Florian L Muller; Wenbo Qi; Arlan G Richardson; Arunabh Bhattacharya; Asish Chaudhuri; Christopher R Hayworth; Jing-Yi Huang; Eric Verdin; Holly Van Remmen
Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD.
Aging cell 2012;11(5):770-82.
2012: Delira Robbins; Holly Van Remmen; David B Wang; Stephan N Witt; Jennifer A Wittwer; Tak Yee Aw; Magdalena L Circu; Sarah Codarin; Ting-Ting Huang; Ronald L Klein; Arlan G Richardson; Yunfeng Zhao
Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase.
Cancer science 2012;103(8):1429-33.
2012: Arunabh Bhattacharya; Alex Bokov; Vivian Diaz; Amanda L Jernigan; Keith Maslin; Florian L Muller; Arlan G Richardson; Holly Van Remmen
Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS.
Neurobiology of aging 2012;33(8):1829-32.
2012: Michael S Lustgarten; Florian L Muller; Arlan G Richardson; Takahiko Shimizu; Takuji Shirasawa; Arunabh Bhattacharya; Youngmok C Jang; Holly Van Remmen
Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels.
Biochemical and biophysical research communications 2012;422(3):515-21.
2012: Si-Eun Yoo; Arlan G Richardson; Carmen Rios; Holly Van Remmen; Liuji Chen; Yuhong Liu; Ren Na; Qitao Ran
Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.
Free radical biology & medicine 2012;52(9):1820-7.
2012: Rochelle Wei; Arunabh Bhattacharya; Naveen Chintalaramulu; Amanda L Jernigan; Yuhong Liu; Holly Van Remmen; Asish Chaudhuri
Protein misfolding, mitochondrial dysfunction and muscle loss are not directly dependent on soluble and aggregation state of mSOD1 protein in skeletal muscle of ALS.
Biochemical and biophysical research communications 2012;417(4):1275-9.
2012: Adam B Salmon; Holly Van Remmen; Lisa C Flores; Yan Li; Arlan G Richardson; Yuji Ikeno
Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice.
Pathobiology of aging & age related diseases 2012;2():.
2012: Jean Charchaflieh; Asher Emanuel; Georges I Labaze; Haekyung Lee; Pulsar Li; Arlan Richardson; Helen Stutz; Holly Van Remmen; Ming Zhang
Overexpression of human SOD1 improves survival of mice susceptible to endotoxic shock.
Journal of inflammation research 2012;5():51-8.
2012: Jennalynn Styskal; Holly Van Remmen; Arlan G Richardson; Adam B Salmon
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?
Free radical biology & medicine 2012;52(1):46-58.
2011: Huiyun Liang; Arlan G Richardson; Walter F Ward; Arunabh Bhattacharya; Alex F Bokov; Youngmok C Jang; Amanda Jernigan; Yan Li; Holly Van Remmen
PGC-1α protects neurons and alters disease progression in an amyotrophic lateral sclerosis mouse model.
Muscle & nerve 2011;44(6):947-56.
2011: Viviana I Pérez; Wenbo Qi; Arlan G Richardson; Marisela Rodriguez; Kaoru Tominaga; Holly Van Remmen; Celeste R Webb; Junji Yodoi; Yiqiang Zhang; Alex Bokov; Asish Chaudhuri; Lisa A Cortez; Wilson Fok; Gene B Hubbard; Dean P Jones; Shuko Lee; Christie M Lew; Yuji Ikeno
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 2011;66(12):1286-99.
2011: Giorgos K Sakellariou; James G Tidball; Holly Van Remmen; Aphrodite Vasilaki; Lea Zibrik; Tabitha Kabayo; Anne McArdle; Francis McArdle; Jesus Palomero; Deborah Pye; Arlan G Richardson; Malcolm J Jackson
Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.
Aging cell 2011;10(5):749-60.
2011: Jennifer A Wittwer; Sarah Codarin; Ting-Ting Huang; Christopher G Kevil; Arlan G Richardson; Delira Robbins; xinggui shen; Holly Van Remmen; Fei Wang; Yunfeng Zhao
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells.
Cancer prevention research (Philadelphia, Pa.) 2011;4(9):1476-84.
2011: Sangeeta Ghosh; Joaquin Joya-Galeana; Natalie Lefort; Raweewan Lertwattanarak; Lawrence J. Manderino; Marjorie Molina-Carrion; Muhammad Abdul-Ghani; Benjamin P Bowen; Ralph DeFronzo; Jose de Jesus Garduno-Garcia; Arlan G Richardson; Holly Van Remmen; Nicolas Musi
Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance.
Diabetes 2011;60(8):2051-60.
2011: Michael S Lustgarten; Florian L Muller; Wenbo Qi; Yuejuan Qin; Arlan G Richardson; Yun Shi; Takahiko Shimizu; Takuji Shirasawa; Arunabh Bhattacharya; Patricia Dahia; Youngmok C Jang; Yuhong Liu; Holly Van Remmen
MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging.
Aging cell 2011;10(3):493-505.
2011: Arunabh Bhattacharya; Michael Lustgarten; Yun Shi; Yuhong Liu; Youngmok C Jang; Daniel Pulliam; Amanda L Jernigan; Holly Van Remmen
Increased mitochondrial matrix-directed superoxide production by fatty acid hydroperoxides in skeletal muscle mitochondria.
Free radical biology & medicine 2011;50(5):592-601.
2011: Youngmok C Jang; Holly Van Remmen
Age-associated alterations of the neuromuscular junction.
Experimental gerontology 2011;46(2-3):193-8.
2011: Michael P Siegel; Steven R Smith; Holly Van Remmen; Hui Xie; Richard Beyer; Gary Knowels; Shane E Kruse; Adam Salmon; David J Marcinek
Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.
PloS one 2011;6(11):e26963.
2011: Joyce M Velez; Sumitra Miriyala; Ramaneeya Nithipongvanitch; Teresa Noel; Chotiros D Plabplueng; Terry Oberley; Paiboon Jungsuwadee; Holly Van Remmen; Mary Vore; Daret K St Clair
p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury.
PloS one 2011;6(3):e18005.
2010: Aphrodite Vasilaki; Jack H van der Meulen; Lisa M Larkin; Dawn C Harrison; Timothy Pearson; Holly Van Remmen; Arlan G Richardson; Susan Brooks Herzog; Malcolm J Jackson; Anne McArdle
The age-related failure of adaptive responses to contractile activity in skeletal muscle is mimicked in young mice by deletion of Cu,Zn superoxide dismutase.
Aging cell 2010;9(6):979-90.
2010: Yun Shi; Rochelle Buffenstein; Daniel A Pulliam; Holly Van Remmen
Comparative studies of oxidative stress and mitochondrial function in aging.
Integrative and comparative biology 2010;50(5):869-79.
2010: Yiqiang Zhang; Hong-Mei Zhang; Yun Shi; Michael Lustgarten; Yan Li; Wenbo Qi; Bin-Xian Zhang; Holly Van Remmen
Loss of manganese superoxide dismutase leads to abnormal growth and signal transduction in mouse embryonic fibroblasts.
Free radical biology & medicine 2010;49(8):1255-62.
2010: Elaine D O'Neill; John P H Wilding; C Ronald Kahn; Holly Van Remmen; Anne McArdle; Malcolm Jackson; Graeme L Close
Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation.
Age (Dordrecht, Netherlands) 2010;32(2):209-22.
2010: Youngmok C Jang; Michael S Lustgarten; Yuhong Liu; Florian L Muller; Arunabh Bhattacharya; Hanyu Liang; Adam B Salmon; Susan Brooks Herzog; Lisa M Larkin; Christopher R Hayworth; Arlan G Richardson; Holly Van Remmen
Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(5):1376-90.
2010: Joseph M McClung; Keith C DeRuisseau; Melissa A Whidden; Holly Van Remmen; Arlan G Richardson; Wook Song; Ioannis S Vrabas; Scott K Powers
Overexpression of antioxidant enzymes in diaphragm muscle does not alter contraction-induced fatigue or recovery.
Experimental physiology 2010;95(1):222-31.
2009: Michael S Lustgarten; Youngmok C Jang; Yuhong Liu; Florian L Muller; Wenbo Qi; Mark Steinhelper; Susan Brooks Herzog; Lisa M Larkin; Takahiko Shimizu; Takuji Shirasawa; Linda McManus; Arunabh Bhattacharya; Arlan G Richardson; Holly Van Remmen
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
American journal of physiology. Cell physiology 2009;297(6):C1520-32.
2009: Yiqiang Zhang; Yuji Ikeno; Wenbo Qi; Asish Chaudhuri; Yan Li; Alex Bokov; Suzanne R Thorpe; John W Baynes; Charles Epstein; Arlan G Richardson; Holly Van Remmen
Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(12):1212-20.
2009: Youngmok C Jang; Viviana Perez; Wook Song; Michael S Lustgarten; Adam B Salmon; James Mele; Wenbo Qi; Yuhong Liu; Hanyu Liang; Asish Chaudhuri; Yuji Ikeno; Charles J Epstein; Holly Van Remmen; Arlan G Richardson
Overexpression of Mn superoxide dismutase does not increase life span in mice.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(11):1114-25.
2009: Kyle Hoehn; Adam B Salmon; Cordula Hohnen-Behrens; Nigel Turner; Andrew J Hoy; Ghassan J Maghzal; Roland Stocker; Holly Van Remmen; Edward W Kraegen; Greg J Cooney; Arlan G Richardson; David E James
Insulin resistance is a cellular antioxidant defense mechanism.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17787-92.
2009: Viviana Perez; Alex Bokov; Holly Van Remmen; James Mele; Qitao Ran; Yuji Ikeno; Arlan G Richardson
Is the oxidative stress theory of aging dead?
Biochimica et biophysica acta 2009;1790(10):1005-14.
2009: Diane C Cabelof; Hiral V Patel; Qing Chen; Holly Van Remmen; Larry H Matherly; Yubin Ge; Jeffrey W Taub
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome.
Blood 2009;114(13):2753-63.
2009: Kirk Simon; Anju Mukundan; Samantha Dewundara; Holly Van Remmen; Alan Anthony Dombkowski; Diane C Cabelof
Transcriptional profiling of the age-related response to genotoxic stress points to differential DNA damage response with age.
Mechanisms of ageing and development 2009;130(9):637-47.
2009: Warren Ladiges; Holly Van Remmen; John Strong; Yuji Ikeno; piper meigs treuting; Peter Rabinovitch; Arlan G Richardson
Lifespan extension in genetically modified mice.
Aging cell 2009;8(4):346-52.
2009: Hanyu Liang; Qitao Ran; Youngmok Charles Jang; Deborah Holstein; James D Lechleiter; Tiffany McDonald-Marsh; Andrej Musatov; Wook Song; Holly Van Remmen; Arlan G Richardson
Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria.
Free radical biology & medicine 2009;47(3):312-20.
2009: Jaya Dasgupta; Supriya Kar; Holly Van Remmen; J Andres Melendez
Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.
Experimental gerontology 2009;44(8):503-10.
2009: Sukkyoo Lee; Holly Van Remmen; Marie Csete
Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging.
Aging cell 2009;8(3):296-310.
2009: Xianling Liu; Meilian Liu; Jingjing Zhang; Xiang Bai; Fresnida Ramos; Holly Van Remmen; Arlan G Richardson; Fu-You Liu; Lily Dong; Feng Liu
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
American journal of physiology. Endocrinology and metabolism 2009;296(5):E1067-75.
2009: Holly Van Remmen; Dean P Jones
Current thoughts on the role of mitochondria and free radicals in the biology of aging.
The journals of gerontology. Series A, Biological sciences and medical sciences 2009;64(2):171-4.
2009: Viviana Perez; Holly Van Remmen; Alex Bokov; Charles J Epstein; Jan Vijg; Arlan G Richardson
The overexpression of major antioxidant enzymes does not extend the lifespan of mice.
Aging cell 2009;8(1):73-5.
2009: Isabelle Larosche; Amal Choumar; Bernard Fromenty; Philippe Lettéron; Adjé Abbey-Toby; Holly Van Remmen; Charles J Epstein; Arlan G Richardson; Gérard Feldmann; Dominique Pessayre; Abdellah Mansouri
Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.
Toxicology and applied pharmacology 2009;234(3):326-38.
2009: Arunabh Bhattacharya; Florian Muller; Yuhong Liu; Marian Sabia; Hanyu Liang; Wook Song; Youngmok C Jang; Qitao Ran; Holly Van Remmen
Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria.
The Journal of biological chemistry 2009;284(1):46-55.
2008: Liuji Chen; Ren Na; Mingjun Gu; Adam B Salmon; Yuhong Liu; Hanyu Liang; Wenbo Qi; Holly Van Remmen; Arlan G Richardson; Qitao Ran
Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice.
Aging cell 2008;7(6):866-78.
2008: Anson Pierce; Hamid Mirzaei; Florian Muller; Eric De Waal; Alexander B Taylor; Shanique Leonard; Holly Van Remmen; Fred Regnier; Arlan G Richardson; Asish Chaudhuri
GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis.
Journal of molecular biology 2008;382(5):1195-210.
2008: Florian Muller; Yuhong Liu; Amanda Jernigan; David R Borchelt; Arlan G Richardson; Holly Van Remmen
MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models.
Muscle & nerve 2008;38(3):1173-83.
2008: Muhammad Abdul-Ghani; Florian Muller; Yuhong Liu; Alberto O Chavez; Bogdan Balas; Pengou Zuo; Zhi Chang; Devjit Tripathy; Rucha Jani; Marjorie Molina-Carrion; Adriana Monroy; Franco Folli; Holly Van Remmen; Ralph DeFronzo
Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E678-85.
2008: Eun-Soo Han; Florian Muller; Viviana Perez; Wenbo Qi; Huiyun Liang; Liang Xi; Chunxiao Fu; Erin Doyle; Morgen Hickey; John Cornell; Charles J Epstein; L Jackson Roberts; Holly Van Remmen; Arlan G Richardson
The in vivo gene expression signature of oxidative stress.
Physiological genomics 2008;34(1):112-26.
2008: Jing Lin; Elizabeth F Lopez; Yufang Jin; Holly Van Remmen; Terry Bauch; Hai-Chao Han; Merry Lindsey
Age-related cardiac muscle sarcopenia: Combining experimental and mathematical modeling to identify mechanisms.
Experimental gerontology 2008;43(4):296-306.
2008: Viviana Perez; Christie M Lew; Lisa A Cortez; Celeste R Webb; Marisela Rodriguez; Yuhong Liu; Wenbo Qi; Yan Li; Asish Chaudhuri; Holly Van Remmen; Arlan G Richardson; Yuji Ikeno
Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress.
Free radical biology & medicine 2008;44(5):882-92.
2008: Florian Muller; Yuhong Liu; Muhammad Abdul-Ghani; Michael S Lustgarten; Arunabh Bhattacharya; Youngmok C Jang; Holly Van Remmen
High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates.
The Biochemical journal 2008;409(2):491-9.
2007: Qitao Ran; Hanyu Liang; Yuji Ikeno; Wenbo Qi; Tomas A Prolla; L Jackson Roberts; Norman Wolf; Holly Van Remmen; Holly VanRemmen; Arlan G Richardson
Reduction in glutathione peroxidase 4 increases life span through increased sensitivity to apoptosis.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(9):932-42.
2007: Florian Muller; Wook Song; Youngmok C Jang; Yuhong Liu; Marian Sabia; Arlan G Richardson; Holly Van Remmen
Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(3):R1159-68.
2007: Florian Muller; Michael S Lustgarten; Youngmok Jang; Arlan G Richardson; Holly Van Remmen
Trends in oxidative aging theories.
Free radical biology & medicine 2007;43(4):477-503.
2007: Hanyu Liang; Holly Van Remmen; Victoria Frohlich; James D Lechleiter; Arlan G Richardson; Qitao Ran
Gpx4 protects mitochondrial ATP generation against oxidative damage.
Biochemical and biophysical research communications 2007;356(4):893-8.
2007: Aphrodite Vasilaki; Deborah Simpson; Francis McArdle; Lynne McLean; Robert J Beynon; Holly Van Remmen; Arlan G Richardson; Anne McArdle; John A Faulkner; Malcolm J Jackson
Formation of 3-nitrotyrosines in carbonic anhydrase III is a sensitive marker of oxidative stress in skeletal muscle.
Proteomics. Clinical applications 2007;1(4):362-72.
2007: Jinsook Chang; John Cornell; Holly Van Remmen; Kevin Hakala; Walter F Ward; Arlan G Richardson
Effect of aging and caloric restriction on the mitochondrial proteome.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(3):223-34.
2007: Tatiana Y Kostrominova; Krystyna A Pasyk; Holly Van Remmen; Arlan G Richardson; John A Faulkner
Adaptive changes in structure of skeletal muscles from adult Sod1 homozygous knockout mice.
Cell and tissue research 2007;327(3):595-605.
2006: Aphrodite Vasilaki; Marie Csete; Deborah Pye; S Lee; Jesus Palomero; Francis McArdle; Holly Van Remmen; Arlan G Richardson; Anne McArdle; John A Faulkner; Malcolm Jackson
Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells.
Free radical biology & medicine 2006;41(11):1719-25.
2006: Blazej Andziak; Timothy P O'Connor; Wenbo Qi; Eric M DeWaal; Anson Pierce; Asish Chaudhuri; Holly Van Remmen; Rochelle Buffenstein
High oxidative damage levels in the longest-living rodent, the naked mole-rat.
Aging cell 2006;5(6):463-71.
2006: Asish Chaudhuri; Eric M de Waal; Anson Pierce; Holly Van Remmen; Walter F Ward; Arlan G Richardson
Detection of protein carbonyls in aging liver tissue: A fluorescence-based proteomic approach.
Mechanisms of ageing and development 2006;127(11):849-61.
2006: Sukkyoo Lee; H Stella Shin; Paula Shireman; Aphrodite Vasilaki; Holly Van Remmen; Marie Csete
Glutathione-peroxidase-1 null muscle progenitor cells are globally defective.
Free radical biology & medicine 2006;41(7):1174-84.
2006: Deborah A Ferrington; Tina N Tran; Kathleen L Lew; Holly Van Remmen; Dale S Gregerson
Different death stimuli evoke apoptosis via multiple pathways in retinal pigment epithelial cells.
Experimental eye research 2006;83(3):638-50.
2006: Erik P Rader; Wook Song; Holly Van Remmen; Arlan G Richardson; John A Faulkner
Raising the antioxidant levels within mouse muscle fibres does not affect contraction-induced injury.
Experimental physiology 2006;91(4):781-9.
2006: Qitao Ran; Mingjun Gu; Holly Van Remmen; John Strong; James Roberts; Arlan G Richardson
Glutathione peroxidase 4 protects cortical neurons from oxidative injury and amyloid toxicity.
Journal of neuroscience research 2006;84(1):202-8.
2006: Florian Muller; Wook Song; Yuhong Liu; Asish Chaudhuri; Sandra Pieke-Dahl; John Strong; Ting-Ting Huang; Charles J Epstein; L Jackson Roberts; Marie Csete; John A Faulkner; Holly Van Remmen
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy.
Free radical biology & medicine 2006;40(11):1993-2004.
2006: Diane C Cabelof; Julian J Raffoul; Yubin Ge; Holly Van Remmen; Larry H Matherly; Ahmad R Heydari
Age-related loss of the DNA repair response following exposure to oxidative stress.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(5):427-34.
2006: Anson Pierce; Eric deWaal; Holly Van Remmen; Holly VanRemmen; Arlan G Richardson; Asish Chaudhuri
A novel approach for screening the proteome for changes in protein conformation.
Biochemistry 2006;45(9):3077-85.
2006: James Mele; Holly Van Remmen; Jan Vijg; Arlan G Richardson
Characterization of transgenic mice that overexpress both copper zinc superoxide dismutase and catalase.
Antioxidants & redox signaling 2006;8(3-4):628-38.
2006: Abdellah Mansouri; Florian Muller; Yuhong Liu; Rainer Ng; John A Faulkner; Michelle Hamilton; Arlan G Richardson; Ting-Ting Huang; Charles J Epstein; Holly Van Remmen
Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging.
Mechanisms of ageing and development 2006;127(3):298-306.
2005: Norman Wolf; Philip Penn; William R Pendergrass; Holly Van Remmen; Andrzej Bartke; Peter S Rabinovitch; George M Martin
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence.
Experimental eye research 2005;81(3):276-85.
2005: G C Kujoth; Asimina Hiona; Thomas D Pugh; Shinichi Someya; K Panzer; Stephanie E Wohlgemuth; Tim Hofer; Arnold Y Seo; R Sullivan; Wendy A Jobling; J D Morrow; Holly Van Remmen; John M Sedivy; Tatsuya Yamasoba; Masaru Tanokura; Richard Weindruch; Christiaan Leeuwenburgh; Tomas A Prolla
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
Science (New York, N.Y.) 2005;309(5733):481-4.
2005: Walter F Ward; Wenbo Qi; Holly Van Remmen; William E Zackert; L Jackson Roberts; Arlan G Richardson
Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels.
The journals of gerontology. Series A, Biological sciences and medical sciences 2005;60(7):847-51.
2005: Samuel E Schriner; Nancy J Linford; George M Martin; piper meigs treuting; Charles E Ogburn; Mary J Emond; Pinar E Coskun; Warren C Ladiges; Norman Wolf; Holly Van Remmen; Douglas C Wallace; Peter S Rabinovitch
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Science (New York, N.Y.) 2005;308(5730):1909-11.
2005: Earl R Stadtman; Holly Van Remmen; Arlan G Richardson; Nancy B Wehr; Rodney L Levine
Methionine oxidation and aging.
Biochimica et biophysica acta 2005;1703(2):135-40.
2005: Sailaja Elchuri; Terry D Oberley; Wenbo Qi; Richard S Eisenstein; L Jackson Roberts; Holly Van Remmen; Charles J Epstein; Ting-Ting Huang
CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.
Oncogene 2005;24(3):367-80.
2004: Qitao Ran; Hanyu Liang; Minjun Gu; Wenbo Qi; Christi A Walter; L Jackson Roberts; Brian Herman; Arlan G Richardson; Holly Van Remmen
Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis.
The Journal of biological chemistry 2004;279(53):55137-46.
2004: Florian Muller; Yuhong Liu; Holly Van Remmen
Complex III releases superoxide to both sides of the inner mitochondrial membrane.
The Journal of biological chemistry 2004;279(47):49064-73.
2004: Jinsook Chang; Holly Van Remmen; Walter F Ward; Fred E Regnier; Arlan G Richardson; John Cornell
Processing of data generated by 2-dimensional gel electrophoresis for statistical analysis: missing data, normalization, and statistics.
Journal of proteome research 2004;3(6):1210-8.
2004: Samantha A Tavener; Eizabeth Long; Stephen M Robbins; Krista M McRae; Holly Van Remmen; Paul Kubes
Immune cell Toll-like receptor 4 is required for cardiac myocyte impairment during endotoxemia.
Circulation research 2004;95(7):700-7.
2004: Arlan G Richardson; Feng Liu; Martin Adamo; Holly Van Remmen; James Nelson
The role of insulin and insulin-like growth factor-I in mammalian ageing.
Best practice & research. Clinical endocrinology & metabolism 2004;18(3):393-406.
2004: Holly Van Remmen; Wenbo Qi; Marian Sabia; Gregory Freeman; Larry Estlack; Hong Yang; Zhong Mao Guo; Ting-Ting Huang; John Strong; Shuko Lee; Charles J Epstein; Arlan G Richardson
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.
Free radical biology & medicine 2004;36(12):1625-34.
2004: Anne McArdle; J van der Meulen; Graeme L Close; David M Pattwell; Holly Van Remmen; T T Huang; Arlan G Richardson; C J Epstein; John A Faulkner; Malcolm Jackson
Role of mitochondrial superoxide dismutase in contraction-induced generation of reactive oxygen species in skeletal muscle extracellular space.
American journal of physiology. Cell physiology 2004;286(5):C1152-8.
2004: Xinlian Chen; Hanyu Liang; Holly Van Remmen; Jan Vijg; Arlan G Richardson
Catalase transgenic mice: characterization and sensitivity to oxidative stress.
Archives of biochemistry and biophysics 2004;422(2):197-210.
2003: Holly Van Remmen; Yuji Ikeno; Michelle Hamilton; Mohammad Pahlavani; Norman Wolf; Suzanne R Thorpe; Nathan L Alderson; John W Baynes; Charles J Epstein; Ting-Ting Huang; James Nelson; John Strong; Arlan G Richardson
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging.
Physiological genomics 2003;16(1):29-37.
2003: Qitao Ran; Holly Van Remmen; Mingjun Gu; Wenbo Qi; L Jackson Roberts; Tomas A Prolla; Arlan G Richardson
Embryonic fibroblasts from Gpx4+/- mice: a novel model for studying the role of membrane peroxidation in biological processes.
Free radical biology & medicine 2003;35(9):1101-9.
2003: Holly Van Remmen; Michelle L Hamilton; Arlan G Richardson
Oxidative damage to DNA and aging.
Exercise and sport sciences reviews 2003;31(3):149-53.
2003: Levi J Yant; Qitao Ran; Lin Rao; Holly Van Remmen; Toru Shibatani; Jason G Belter; Lucia Motta; Arlan G Richardson; Tomas A Prolla
The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults.
Free radical biology & medicine 2003;34(4):496-502.
2003: Xinlian Chen; James Mele; Heidi Giese; Holly Van Remmen; Martijn E T Dollé; Mark Steinhelper; Arlan G Richardson; Jan Vijg
A strategy for the ubiquitous overexpression of human catalase and CuZn superoxide dismutase genes in transgenic mice.
Mechanisms of ageing and development 2003;124(2):219-27.
2003: Jinsook Chang; Holly Van Remmen; John Cornell; Arlan G Richardson; Walter F Ward
Comparative proteomics: characterization of a two-dimensional gel electrophoresis system to study the effect of aging on mitochondrial proteins.
Mechanisms of ageing and development 2003;124(1):33-41.
2003: Hong Yang; MingJian Shi; Holly Van Remmen; XinLian Chen; Jan Vijg; Arlan G Richardson; ZhongMao Guo
Reduction of pressor response to vasoconstrictor agents by overexpression of catalase in mice.
American journal of hypertension 2003;16(1):1-5.
2002: Daniela A Bota; Holly Van Remmen; Kelvin J A Davies
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.
FEBS letters 2002;532(1-2):103-6.
2001: ZhongMao Guo; Hong Yang; Michelle L Hamilton; Holly Van Remmen; Arlan G Richardson
Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta.
Mechanisms of ageing and development 2001;122(15):1771-86.
2001: Holly Van Remmen; M D Williams; Z Guo; L Estlack; Hong Yang; E J Carlson; C J Epstein; T T Huang; Arlan G Richardson
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis.
American journal of physiology. Heart and circulatory physiology 2001;281(3):H1422-32.
2001: Michelle L Hamilton; Holly Van Remmen; J A Drake; Hong Yang; ZhongMao Guo; Kristen Kewitt; Christi A Walter; Arlan G Richardson
Does oxidative damage to DNA increase with age?
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10469-74.
2001: Z Guo; Holly Van Remmen; Hong Yang; Xinlian Chen; James Mele; Jan Vijg; C J Epstein; Ye-Shih Ho; Arlan G Richardson
Changes in expression of antioxidant enzymes affect cell-mediated LDL oxidation and oxidized LDL-induced apoptosis in mouse aortic cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(7):1131-8.
2001: Holly Van Remmen; Arlan G Richardson
Oxidative damage to mitochondria and aging.
Experimental gerontology 2001;36(7):957-68.
2001: Michelle L Hamilton; Z Guo; Clifton David Fuller; Holly Van Remmen; Walter F Ward; Steven Austad; Dean A Troyer; Ian M Thompson; Arlan G Richardson
A reliable assessment of 8-oxo-2-deoxyguanosine levels in nuclear and mitochondrial DNA using the sodium iodide method to isolate DNA.
Nucleic acids research 2001;29(10):2117-26.
2001: Holly Van Remmen; Z Guo; Arlan G Richardson
The anti-ageing action of dietary restriction.
Novartis Foundation symposium 2001;235():221-30; discussion 230-3.
1999: Holly Van Remmen; C Salvador; Hong Yang; T T Huang; C J Epstein; Arlan G Richardson
Characterization of the antioxidant status of the heterozygous manganese superoxide dismutase knockout mouse.
Archives of biochemistry and biophysics 1999;363(1):91-7.
1998: M D Williams; Holly Van Remmen; C C Conrad; T T Huang; C J Epstein; Arlan G Richardson
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice.
The Journal of biological chemistry 1998;273(43):28510-5.
1998: ZhongMao Guo; Holly Van Remmen; W T Wu; Arlan G Richardson
Effect of cAMP-induced transcription on the repair of the phosphoenolpyruvate carboxykinase gene by hepatocytes isolated from young and old rats.
Mutation research 1998;409(1):37-48.
1998: Holly Van Remmen; Walter F Ward
Effect of dietary restriction on hepatic and renal phosphoenolpyruvate carboxykinase induction in young and old Fischer 344 rats.
Mechanisms of ageing and development 1998;104(3):263-75.
1998: Holly Van Remmen; M D Williams; Hong Yang; Christi A Walter; Arlan G Richardson
Analysis of the transcriptional activity of the 5'-flanking region of the rat catalase gene in transiently transfected cells and in transgenic mice.
Journal of cellular physiology 1998;174(1):18-26.
1997: H Mann; Michael T McCoy; J Subramaniam; Holly Van Remmen; Jean Lud Cadet
Overexpression of superoxide dismutase and catalase in immortalized neural cells: toxic effects of hydrogen peroxide.
Brain research 1997;770(1-2):163-8.
1997: Holly Van Remmen; Walter F Ward
Effect of age on the activity of phosphoenolpyruvate carboxykinase in the kidney following fasting and refeeding.
Mechanisms of ageing and development 1997;97(3):237-48.
1996: Holly Van Remmen; M D Williams; Ahmad R Heydari; R Takahashi; H Y Chung; B P Yu; Arlan G Richardson
Expression of genes coding for antioxidant enzymes and heat shock proteins is altered in primary cultures of rat hepatocytes.
Journal of cellular physiology 1996;166(2):453-60.
1995: E Xia; G Rao; Holly Van Remmen; Ahmad R Heydari; Arlan G Richardson
Activities of antioxidant enzymes in various tissues of male Fischer 344 rats are altered by food restriction.
The Journal of nutrition 1995;125(2):195-201.
1994: Holly Van Remmen; Walter F Ward
Effect of age on induction of hepatic phosphoenolpyruvate carboxykinase by fasting.
The American journal of physiology 1994;267(2 Pt 1):G195-200.