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Dominic Campopiano

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TOP 3
Scott Baxter; Fraser Brown; Ian G Fotheringham; Gideon Grogan; Karen E Holt-Tiffin; Sylvain Royer; Ian N Taylor; Dominic J Campopiano
An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids.
Alexandra J Clipson; Venugopal T Bhat; Dominic J Campopiano; Anne M Caniard; Iain W McNae; Michael F Greaney
Bivalent enzyme inhibitors discovered using dynamic covalent chemistry.
Jonathan Lowther; James H Naismith; Teresa M Dunn; Dominic J Campopiano
Structural, mechanistic and regulatory studies of serine palmitoyltransferase.

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2012: Scott Baxter; Fraser Brown; Ian G Fotheringham; Gideon Grogan; Karen E Holt-Tiffin; Sylvain Royer; Ian N Taylor; Dominic J Campopiano
An improved racemase/acylase biotransformation for the preparation of enantiomerically pure amino acids.
Journal of the American Chemical Society 2012;134(47):19310-3.
2012: Alexandra J Clipson; Venugopal T Bhat; Dominic J Campopiano; Anne M Caniard; Iain W McNae; Michael F Greaney
Bivalent enzyme inhibitors discovered using dynamic covalent chemistry.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(34):10562-70.
2012: Jonathan Lowther; James H Naismith; Teresa M Dunn; Dominic J Campopiano
Structural, mechanistic and regulatory studies of serine palmitoyltransferase.
Biochemical Society transactions 2012;40(3):547-54.
2012: Arindam Mukherjee; Dean Rea; Paul R Bilton; Dominic J Campopiano; Adam Janoschka; Pat R R Langridge-Smith; Logan Mackay; Volker Schünemann; Thomas Teschner; Alfred X Trautwein; Haizhong Zhu; Peter J Sadler
Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2012;17(4):573-88.
2011: Jonathan Lowther; Marine C Raman; Guillaume Charmier; Hideyuki Hayashi; Hiroko Ikushiro; Dominic J Campopiano
Role of a conserved arginine residue during catalysis in serine palmitoyltransferase.
FEBS letters 2011;585(12):1729-34.
2010: Emily S Seo; Bärbel S Blaum; Thomas Vargues; Martin De Cecco; Jon A Deakin; Malcolm Lyon; Perdita E Barran; Dominic J Campopiano; Dusan Uhrín
Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans.
Biochemistry 2010;49(49):10486-95.
2010: Marine C C Raman; Kenneth A Johnson; David J Clarke; James H Naismith; Dominic J Campopiano
The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein.
Biopolymers 2010;93(9):811-22.
2010: Jonathan Lowther; Beverley A Yard; Kenneth A Johnson; Lester G Carter; Venugopal T Bhat; Marine C C Raman; David J Clarke; Britta Ramakers; Stephen McMahon; James H Naismith; Dominic J Campopiano
Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation.
Molecular bioSystems 2010;6(9):1682-93.
2010: Karin Bodewits; Christian R H Raetz; John R Govan; Dominic J Campopiano
Antimicrobial activity of CHIR-090, an inhibitor of lipopolysaccharide biosynthesis, against the Burkholderia cepacia complex.
Antimicrobial agents and chemotherapy 2010;54(8):3531-3.
2010: Venugopal T Bhat; Anne M Caniard; Torsten Luksch; Ruth Brenk; Dominic J Campopiano; Michael F Greaney
Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry.
Nature chemistry 2010;2(6):490-7.
2010: Natalie L Reynolds; Martin De Cecco; Karen Taylor; Chloe Stanton; Fiona M Kilanowski; Jason Kalapothakis; Emily Seo; Dusan Uhrin; Dominic J Campopiano; John R W Govan; Derek Macmillan; Perdita E Barran; Julia R Dorin
Peptide fragments of a beta-defensin derivative with potent bactericidal activity.
Antimicrobial agents and chemotherapy 2010;54(5):1922-9.
2010: Martin De Cecco; Emily S Seo; David J Clarke; Bryan J McCullough; Karen Taylor; Derek Macmillan; Julia R Dorin; Dominic J Campopiano; Perdita E Barran
Conformational preferences of linear beta-defensins are revealed by ion mobility-mass spectrometry.
The journal of physical chemistry. B 2010;114(6):2312-8.
2010: David J Clarke; Ximena P Ortega; C Logan Mackay; Miguel A Valvano; John R W Govan; Dominic J Campopiano; Pat Langridge-Smith; Alan Brown
Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity.
Biochemistry 2010;49(6):1319-30.
2010: Felicetta Landi; Conny M Johansson; Dominic J Campopiano; Alison N Hulme
Synthesis and application of a new cleavable linker for "click"-based affinity chromatography.
Organic & biomolecular chemistry 2010;8(1):56-9.
2009: Simon Newstead; Philip W Fowler; Paul Bilton; Elisabeth P Carpenter; Peter J Sadler; Dominic J Campopiano; Mark S P Sansom; So Iwata
Insights into how nucleotide-binding domains power ABC transport.
Structure (London, England : 1993) 2009;17(9):1213-22.
2009: Katherine Miles; David J Clarke; Wuyuan Lu; Zaneta Sibinska; Paula E Beaumont; Donald J Davidson; Tom Barr; Dominic J Campopiano; Mohini Gray
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):2122-32.
2009: Marine C C Raman; Kenneth Alan Johnson; Beverley A Yard; Jonathan Lowther; Lester G Carter; James H Naismith; Dominic J Campopiano
The external aldimine form of serine palmitoyltransferase: structural, kinetic, and spectroscopic analysis of the wild-type enzyme and HSAN1 mutant mimics.
The Journal of biological chemistry 2009;284(25):17328-39.
2009: Slade Loutet; S Josefin Bartholdson; John R W Govan; Dominic J Campopiano; Miguel A Valvano
Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia.
Microbiology (Reading, England) 2009;155(Pt 6):2029-39.
2009: Emily S Seo; Thomas Vargues; David J Clarke; Dusan Uhrín; Dominic J Campopiano
Preparation of isotopically labelled recombinant beta-defensin for NMR studies.
Protein expression and purification 2009;65(2):179-84.
2009: David J Clarke; C Logan Mackay; Dominic J Campopiano; Pat Langridge-Smith; Alan Brown
Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry.
Biochemistry 2009;48(18):3904-14.
2009: Cecile M Tron; Iain W McNae; Margaret Nutley; David J Clarke; Alan Cooper; Malcolm D Walkinshaw; Robert L Baxter; Dominic J Campopiano
Structural and functional studies of the biotin protein ligase from Aquifex aeolicus reveal a critical role for a conserved residue in target specificity.
Journal of molecular biology 2009;387(1):129-46.
2009: Thomas Vargues; Gareth J Morrison; Emily S Seo; David J Clarke; Helen L Fielder; Julien Bennani; Uday Pathania; Fiona Kilanowski; Julia R Dorin; John R W Govan; C Logan Mackay; Dusan Uhrín; Dominic J Campopiano
Efficient production of human beta-defensin 2 (HBD2) in Escherichia coli.
Protein and peptide letters 2009;16(6):668-76.
2009: V Ganesh; Karin Bodewits; S Josefin Bartholdson; Daniela Natale; Dominic J Campopiano; Juan C Mareque-Rivas
Effective binding and sensing of lipopolysaccharide: combining complementary pattern recognition receptors.
Angewandte Chemie (International ed. in English) 2009;48(2):356-60.
2008: Manish Gupta; Anne Caniard; Angeles Touceda-Varela; Dominic J Campopiano; Juan C Mareque-Rivas
Nitrilotriacetic acid-derivatized quantum dots for simple purification and site-selective fluorescent labeling of active proteins in a single step.
Bioconjugate chemistry 2008;19(10):1964-7.
2008: S Josefin Bartholdson; Alan Brown; Ben R Mewburn; David J Clarke; Stephen C Fry; Dominic J Campopiano; John R W Govan
Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex.
Microbiology (Reading, England) 2008;154(Pt 8):2513-21.
2008: Karen Taylor; David J Clarke; Bryan McCullough; Wutharath Chin; Emily Seo; De Yang; Joost Oppenheim; Dusan Uhrin; John R W Govan; Dominic J Campopiano; Derek MacMillan; Perdita E Barran; Julia R Dorin
Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3.
The Journal of biological chemistry 2008;283(11):6631-9.
2007: David J Clarke; Dominic J Campopiano
Maturation of McjA precursor peptide into active microcin MccJ25.
Organic & biomolecular chemistry 2007;5(16):2564-6.
2007: Beverley A Yard; Lester G Carter; Kenneth Alan Johnson; Ian M Overton; Mark Dorward; Huanting Liu; Stephen McMahon; Muse Oke; Daphné Puech; Geoffrey J Barton; James H Naismith; Dominic J Campopiano
The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis.
Journal of molecular biology 2007;370(5):870-86.
2007: Xiangyang Liang; Dominic J Campopiano; Peter J Sadler
Metals in membranes.
Chemical Society reviews 2007;36(6):968-92.
2007: Karen Taylor; Bryan McCullough; David J Clarke; Ross J Langley; Tali Pechenick; Adrian Hill; Dominic J Campopiano; Perdita E Barran; Julia R Dorin; John R W Govan
Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens.
Antimicrobial agents and chemotherapy 2007;51(5):1719-24.
2007: Ximena P Ortega; Silvia T Cardona; Alan Brown; Slade Loutet; Ronald S Flannagan; Dominic J Campopiano; John R W Govan; Miguel A Valvano
A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.
Journal of bacteriology 2007;189(9):3639-44.
2007: Claudia A Blindauer; M Tahir Razi; Dominic J Campopiano; Peter J Sadler
Histidine ligands in bacterial metallothionein enhance cluster stability.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(3):393-405.
2006: Baolu Shi; Ross Stevenson; Dominic J Campopiano; Michael F Greaney
Discovery of glutathione S-transferase inhibitors using dynamic combinatorial chemistry.
Journal of the American Chemical Society 2006;128(26):8459-67.
2006: Maolin Guo; Ian Harvey; Dominic J Campopiano; Peter J Sadler
Short oxo-titanium(IV) bond in bacterial transferrin: a protein target for metalloantibiotics.
Angewandte Chemie (International ed. in English) 2006;45(17):2758-61.
2006: Dmitriy Alexeev; Robert L Baxter; Dominic J Campopiano; Olivier Kerbarh; Lindsay Sawyer; Nicholas Tomczyk; Rory Munro Watt; Scott P Webster
Suicide inhibition of alpha-oxamine synthases: structures of the covalent adducts of 8-amino-7-oxononanoate synthase with trifluoroalanine.
Organic & biomolecular chemistry 2006;4(7):1209-12.
2006: D J Clarke; Dominic J Campopiano
Structural and functional studies of defensin-inspired peptides.
Biochemical Society transactions 2006;34(Pt 2):251-6.
2006: Olivier Kerbarh; Dominic J Campopiano; Robert L Baxter
Mechanism of alpha-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction.
Chemical communications (Cambridge, England) 2006;(1):60-2.
2005: Ross J Langley; Dervla T Kenna; Josefin Bartholdson; Dominic J Campopiano; John R W Govan
Temperate bacteriophages DK4 and BcepMu from Burkholderia cenocepacia J2315 are identical.
FEMS immunology and medical microbiology 2005;45(2):349-50.
2004: Dominic J Campopiano; David J Clarke; Nick C Polfer; Perdita E Barran; Ross J Langley; John R W Govan; Alison Maxwell; Julia R Dorin
Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity.
The Journal of biological chemistry 2004;279(47):48671-9.
2004: Weiqing Zhong; Dmitriy Alexeev; Ian Harvey; Maolin Guo; Dominic J B Hunter; Haizhong Zhu; Dominic J Campopiano; Peter J Sadler
Assembly of an oxo-zirconium(IV) cluster in a protein cleft.
Angewandte Chemie (International ed. in English) 2004;43(44):5914-8.
2004: David J Clarke; Christopher G Northey; Lynsey A Mack; Iain W McNae; Dmitriy Alexeev; Lindsay Sawyer; Dominic J Campopiano
Cloning, expression, purification, crystallization and preliminary X-ray characterization of the full-length single-stranded DNA-binding protein from the hyperthermophilic bacterium Aquifex aeolicus.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 11):2009-12.
2003: Haizhong Zhu; Dmitriy Alexeev; Dominic J B Hunter; Dominic J Campopiano; Peter J Sadler
Oxo-iron clusters in a bacterial iron-trafficking protein: new roles for a conserved motif.
The Biochemical journal 2003;376(Pt 1):35-41.
2003: Rachel S Breen; Dominic J Campopiano; Scott Webster; Mhairi Brunton; Rory Munro Watt; Robert L Baxter
The mechanism of 7,8-diaminopelargonate synthase; the role of S-adenosylmethionine as the amino donor.
Organic & biomolecular chemistry 2003;1(20):3498-9.
2003: Dmitriy Alexeev; Haizhong Zhu; Maolin Guo; Weiqing Zhong; Dominic J B Hunter; Weiping Yang; Dominic J Campopiano; Peter J Sadler
A novel protein-mineral interface.
Nature structural biology 2003;10(4):297-302.
2003: David J Clarke; Joseph Coulson; Ranald Baillie; Dominic J Campopiano
Biotinylation in the hyperthermophile Aquifex aeolicus.
European journal of biochemistry / FEBS 2003;270(6):1277-87.
2003: Maolin Guo; Ian Harvey; Weiping Yang; Lorraine S Coghill; Dominic J Campopiano; John A Parkinson; Ross T A MacGillivray; Wesley R Harris; Peter J Sadler
Synergistic anion and metal binding to the ferric ion-binding protein from Neisseria gonorrhoeae.
The Journal of biological chemistry 2003;278(4):2490-502.
2002: Nicholas H Tomczyk; Joanne E Nettleship; Robert L Baxter; Hilary J Crichton; Scott P Webster; Dominic J Campopiano
Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway.
FEBS letters 2002;513(2-3):299-304.
2000: C Leadbeater; Lisa McIver; Dominic J Campopiano; Scott P Webster; Robert L Baxter; Sharon M Kelly; Nicholas C Price; Dominikus Lysek; Michael A Noble; Stephen K Chapman; Andrew W Munro
Probing the NADPH-binding site of Escherichia coli flavodoxin oxidoreductase.
The Biochemical journal 2000;352 Pt 2():257-66.
2000: Lisa McIver; Robert L Baxter; Dominic J Campopiano
Identification of the [Fe-S] cluster-binding residues of Escherichia coli biotin synthase.
The Journal of biological chemistry 2000;275(18):13888-94.
2000: Scott P Webster; Dmitriy Alexeev; Dominic J Campopiano; Rory Munro Watt; Marina Alexeeva; Lindsay Sawyer; Robert L Baxter
Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies.
Biochemistry 2000;39(3):516-28.
1998: Dmitriy Alexeev; Marina Alexeeva; Robert L Baxter; Dominic J Campopiano; Scott P Webster; Lindsay Sawyer
The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.
Journal of molecular biology 1998;284(2):401-19.
1998: Lisa McIver; C Leadbeater; Dominic J Campopiano; Robert L Baxter; Simon Daff; Stephen K Chapman; Andrew W Munro
Characterisation of flavodoxin NADP+ oxidoreductase and flavodoxin; key components of electron transfer in Escherichia coli.
European journal of biochemistry / FEBS 1998;257(3):577-85.
1998: Lisa McIver; C Leadbeater; Dominic J Campopiano; Dmitriy Alexeev; Robert L Baxter
An investigation of flavoprotein redox partners.
Biochemical Society transactions 1998;26(3):S271.
1998: Scott P Webster; Dominic J Campopiano; Dmitriy Alexeev; Marina Alexeeva; Rory Munro Watt; Lindsay Sawyer; Robert L Baxter
Characterisation of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl CoA condensing enzyme.
Biochemical Society transactions 1998;26(3):S268.