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Wim Jiskoot

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Grzegorz Kijanka; Huub Schellekens; Wim Jiskoot; Vera Brinks
Effect of treatment regimen on the immunogenicity of human interferon Beta in immune tolerant mice.
A L Silva; M G Carstens; J Oostendorp; F Ossendorp; R A Rosalia; A Sazak; Wim Jiskoot
Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: low-burst release is crucial for efficient CD8(+) T cell activation.
Ville P Heljo; Wim Jiskoot; Vasco Filipe; Stefan G Romeijn; Anne M Juppo
Stability of rituximab in freeze-dried formulations containing trehalose or melibiose under different relative humidity atmospheres.

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All Publications

2013: Grzegorz Kijanka; Huub Schellekens; Wim Jiskoot; Vera Brinks
Effect of treatment regimen on the immunogenicity of human interferon Beta in immune tolerant mice.
Pharmaceutical research 2013;30(6):1553-60.
2013: A L Silva; M G Carstens; J Oostendorp; F Ossendorp; R A Rosalia; A Sazak; Wim Jiskoot
Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: low-burst release is crucial for efficient CD8(+) T cell activation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2013;83(3):338-45.
2013: Ville P Heljo; Wim Jiskoot; Vasco Filipe; Stefan G Romeijn; Anne M Juppo
Stability of rituximab in freeze-dried formulations containing trehalose or melibiose under different relative humidity atmospheres.
Journal of pharmaceutical sciences 2013;102(2):401-14.
2013: Melody Sauerborn; Huub Schellekens; Miranda M C van Beers; Louis Boon; Wim Jiskoot; Grzegorz M Kijanka; Vera Brinks
Antibody response against Betaferon® in immune tolerant mice: involvement of marginal zone B-cells and CD4+ T-cells and apparent lack of immunological memory.
Journal of clinical immunology 2013;33(1):255-63.
2012: Marie Régnier; Wichard Tilstra; Coenraad Hendriksen; Wim Jiskoot; Bernard Metz; Willem Norde; Gideon F A Kersten
Structural perturbation of diphtheria toxoid upon adsorption to aluminium hydroxide adjuvant.
Vaccine 2012;30(48):6783-8.
2012: Andrea Hawe; Vasco Filipe; Stefan G Romeijn; Wim Jiskoot
Asymmetrical flow field-flow fractionation method for the analysis of submicron protein aggregates.
Journal of pharmaceutical sciences 2012;101(11):4129-39.
2012: Richard Johnson; Wim Jiskoot
Models for evaluation of relative immunogenic potential of protein particles in biopharmaceutical protein formulations.
Journal of pharmaceutical sciences 2012;101(10):3586-92.
2012: Mohsen Tafaghodi; Jean-Pierre Amorij; Gideon F A Kersten; Heleen Kraan; Vinay Saluja; Bram Slütter; Wim Jiskoot
Hepatitis B surface antigen nanoparticles coated with chitosan and trimethyl chitosan: Impact of formulation on physicochemical and immunological characteristics.
Vaccine 2012;30(36):5341-8.
2012: Riccardo Torosantucci; Olivier Mozziconacci; Christian Schöneich; Victor Sharov; Wim Jiskoot
Chemical modifications in aggregates of recombinant human insulin induced by metal-catalyzed oxidation: covalent cross-linking via michael addition to tyrosine oxidation products.
Pharmaceutical research 2012;29(8):2276-93.
2012: Vasco Filipe; Olubukayo Oladunjoye; Robert Poole; Kevin Braeckmans; Wim Jiskoot
Detection and characterization of subvisible aggregates of monoclonal IgG in serum.
Pharmaceutical research 2012;29(8):2202-12.
2012: Koen van der Maaden; Wim Jiskoot; Joke Bouwstra
Microneedle technologies for (trans)dermal drug and vaccine delivery.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(2):645-55.
2012: Jean-Pierre Amorij; Suzanne M Bal; Joke A Bouwstra; Wouter L J Hinrichs; Anke Huckriede; Gideon F A Kersten; Vinay Saluja; Bram Slütter; Wouter F Tonnis; Wim Jiskoot
Towards tailored vaccine delivery: needs, challenges and perspectives.
Journal of controlled release : official journal of the Controlled Release Society 2012;161(2):363-76.
2012: Vasco Filipe; Andrea Hawe; Başak Kükrer; Wim Jiskoot
Transient molten globules and metastable aggregates induced by brief exposure of a monoclonal IgG to low pH.
Journal of pharmaceutical sciences 2012;101(7):2327-39.
2012: Christophe Barnier Quer; Abdelrahman Elsharkawy; Alexander Kros; Stefan Romeijn; Wim Jiskoot
Cationic liposomes as adjuvants for influenza hemagglutinin: more than charge alone.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2012;81(2):294-302.
2012: Hoang Hirschberg; Wim Jiskoot; Gideon F A Kersten; Jessica Loch; Sandra van Kuijk; Joke Bouwstra; Jean-Pierre Amorij
A combined approach of vesicle formulations and microneedle arrays for transcutaneous immunization against hepatitis B virus.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;46(1-2):1-7.
2012: Suzanne M Bal; Joke A Bouwstra; Bram Slütter; Rolf Verheul; Wim Jiskoot
Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: adjuvant- and site-dependent immunogenicity in mice.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;45(4):475-81.
2012: Rolf J Verheul; Sven Bruijns; Pascal H J L F de Jong; Harrie L Glansbeek; Niels Hagenaars; Jacco G M Heldens; Wim E Hennink; Enrico Mastrobattista; Ivo Que; Bram Slütter; Han van den Bosch; Thomas van Es; Ethlinn V B van Gaal; Wim Jiskoot
A step-by-step approach to study the influence of N-acetylation on the adjuvanticity of N,N,N-trimethyl chitosan (TMC) in an intranasal nanoparticulate influenza virus vaccine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2012;45(4):467-74.
2012: Christina Avanti; Henderik W Frijlink; Wim Jiskoot; Hjalmar P Permentier; Robert Poole; Annie van Dam; Wouter L J Hinrichs
A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate.
Molecular pharmaceutics 2012;9(3):554-62.
2012: Wim Jiskoot; C Russell Middaugh; Theodore W Randolph; Christian Schöneich; David B Volkin; Gerhard Winter; Daan J A Crommelin; Wolfgang Friess; John F Carpenter
Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.
Journal of pharmaceutical sciences 2012;101(3):946-54.
2012: Sarah Zölls; Wolfgang Friess; Wim Jiskoot; Ruedeeporn Tantipolphan; Michael Wiggenhorn; Gerhard Winter; Andrea Hawe
Particles in therapeutic protein formulations, Part 1: overview of analytical methods.
Journal of pharmaceutical sciences 2012;101(3):914-35.
2012: Andrea Hawe; Hanns-Christian Mahler; Marco van de Weert; Michael Wiggenhorn; Joerg H O Garbe; Wim Jiskoot
Forced degradation of therapeutic proteins.
Journal of pharmaceutical sciences 2012;101(3):895-913.
2012: Koen van der Maaden; Wim Jiskoot; Alexander Kros; Karen Sliedregt; Joke Bouwstra
Fluorescent nanoparticle adhesion assay: a novel method for surface pKa determination of self-assembled monolayers on silicon surfaces.
Langmuir : the ACS journal of surfaces and colloids 2012;28(7):3403-11.
2012: Miranda M C Van Beers; Francesca Gilli; Theodore W Randolph; Huub Schellekens; Wim Jiskoot
Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene.
Journal of pharmaceutical sciences 2012;101(1):187-99.
2011: Myrra G Carstens; Joke A Bouwstra; Cornelis J Melief; Ferry Ossendorp; Tom H M Ottenhoff; Koen van der Maaden; Daniel van der Velden; Wim Jiskoot
Evaluation of the high-pressure extrusion technique as a method for sizing plasmid DNA-containing cationic liposomes.
Journal of liposome research 2011;21(4):286-95.
2011: Rolf J Verheul; Suzanne M Bal; Joke A Bouwstra; Wim Jiskoot; Bram Slütter; Wim E Hennink
Covalently stabilized trimethyl chitosan-hyaluronic acid nanoparticles for nasal and intradermal vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2011;156(1):46-52.
2011: Vera Brinks; Wim Jiskoot; Huub Schellekens
Immunogenicity of therapeutic proteins: the use of animal models.
Pharmaceutical research 2011;28(10):2379-85.
2011: Miranda M C van Beers; Vera Brinks; Francesca Gilli; Melody Sauerborn; Huub Schellekens; Wim Jiskoot
Oxidized and aggregated recombinant human interferon beta is immunogenic in human interferon beta transgenic mice.
Pharmaceutical research 2011;28(10):2393-402.
2011: Bram Slütter; Suzanne M Bal; Zhi Ding; Wim Jiskoot; Joke A Bouwstra
Adjuvant effect of cationic liposomes and CpG depends on administration route.
Journal of controlled release : official journal of the Controlled Release Society 2011;154(2):123-30.
2011: Andrea Hawe; Wendy L Hulse; Wim Jiskoot; Robert T Forbes
Taylor dispersion analysis compared to dynamic light scattering for the size analysis of therapeutic peptides and proteins and their aggregates.
Pharmaceutical research 2011;28(9):2302-10.
2011: Robert A Poole; Piotr Tomasz Kasper; Wim Jiskoot
Formation of amide- and imide-linked degradation products between the peptide drug oxytocin and citrate in citrate-buffered formulations.
Journal of pharmaceutical sciences 2011;100(7):3018-22.
2011: Riccardo Torosantucci; Basak Kukrer; Anna Mero; Ruedeeporn Tantipolphan; Margot Van Winsen; Wim Jiskoot
Plain and mono-pegylated recombinant human insulin exhibit similar stress-induced aggregation profiles.
Journal of pharmaceutical sciences 2011;100(7):2574-85.
2011: Myrra G Carstens; Kees L M C Franken; Malou Henriksen-Lacey; Joke A Bouwstra; Marcel G M Camps; Ferry Ossendorp; Tom H M Ottenhoff; Yvonne Perrie; Wim Jiskoot
Effect of vesicle size on tissue localization and immunogenicity of liposomal DNA vaccines.
Vaccine 2011;29(29-30):4761-70.
2011: Christina Avanti; Jean-Pierre Amorij; Dewi Setyaningsih; Andrea Hawe; Wim Jiskoot; Jan Visser; Alexej Kedrov; Arnold J M Driessen; W L J Hinrichs; Henderik W Frijlink
A new strategy to stabilize oxytocin in aqueous solutions: I. The effects of divalent metal ions and citrate buffer.
The AAPS journal 2011;13(2):284-90.
2011: Tue Rasmussen; Marco van de Weert; Wim Jiskoot; Marina R Kasimova
Thermal and acid denaturation of bovine lens α-crystallin.
Proteins 2011;79(6):1747-58.
2011: Sukanda Kittipongwarakarn; Andrea Hawe; Ruedeeporn Tantipolphan; Kornvika Limsuwun; Sumana Khomvilai; Satit Puttipipatkhachorn; Wim Jiskoot
New method to produce equine antirabies immunoglobulin F(ab')₂ fragments from crude plasma in high quality and yield.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;78(2):189-95.
2011: Andreas van Maarschalkerweerd; Gert-Jan Wolbink; Steven O Stapel; Wim Jiskoot; Andrea Hawe
Comparison of analytical methods to detect instability of etanercept during thermal stress testing.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;78(2):213-21.
2011: Suzanne M Bal; Bram Slütter; Wim Jiskoot; Joke A Bouwstra
Small is beautiful: N-trimethyl chitosan-ovalbumin conjugates for microneedle-based transcutaneous immunisation.
Vaccine 2011;29(23):4025-32.
2011: Vasco Filipe; Robert Poole; Marika Kutscher; Katrien Forier; Kevin Braeckmans; Wim Jiskoot
Fluorescence single particle tracking for the characterization of submicron protein aggregates in biological fluids and complex formulations.
Pharmaceutical research 2011;28(5):1112-20.
2011: John den Engelsman; Patrick Garidel; Ronald Smulders; Hans Koll; Bryan Smith; Stefan Bassarab; Andreas Seidl; Otmar Hainzl; Wim Jiskoot
Strategies for the assessment of protein aggregates in pharmaceutical biotech product development.
Pharmaceutical research 2011;28(4):920-33.
2011: Vera Brinks; Andrea Hawe; Abdul H H Basmeleh; Liliana Joachin-Rodriguez; Rob Haselberg; Govert W Somsen; Wim Jiskoot; Huub Schellekens
Quality of original and biosimilar epoetin products.
Pharmaceutical research 2011;28(2):386-93.
2011: Suzanne M Bal; Sander Hortensius; Zhi Ding; Wim Jiskoot; Joke A Bouwstra
Co-encapsulation of antigen and Toll-like receptor ligand in cationic liposomes affects the quality of the immune response in mice after intradermal vaccination.
Vaccine 2011;29(5):1045-52.
2011: Chantal Keijzer; Bram Slütter; Ruurd van der Zee; Willem van Eden; Wim Jiskoot; Femke Broere
PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity.
PloS one 2011;6(11):e26684.
2011: Zhi Ding; Suzanne M Bal; Stefan G Romeijn; Gideon F A Kersten; Wim Jiskoot; Joke A Bouwstra
Transcutaneous immunization studies in mice using diphtheria toxoid-loaded vesicle formulations and a microneedle array.
Pharmaceutical research 2011;28(1):145-58.
2010: Suzanne M Bal; Zhi Ding; Elly van Riet; Wim Jiskoot; Joke A Bouwstra
Advances in transcutaneous vaccine delivery: do all ways lead to Rome?
Journal of controlled release : official journal of the Controlled Release Society 2010;148(3):266-82.
2010: Bram Slütter; Suzanne M Bal; Ivo Que; Eric Kaijzel; Clemens Löwik; Joke Bouwstra; Wim Jiskoot
Antigen-adjuvant nanoconjugates for nasal vaccination: an improvement over the use of nanoparticles?
Molecular pharmaceutics 2010;7(6):2207-15.
2010: A H Ghassemi; Mies J van Steenbergen; Herre Talsma; Cornelus F van Nostrum; Wim Jiskoot; D J A Crommelin; Wim E Hennink
Microspheres of hydrophilic PLGA highly attractive for protein delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e39-40.
2010: Hana Robson Marsden; Christophe Barnier Quer; Wim Jiskoot; Alexander Kros
Supramolecular triblock copolymers controlled by the coiled-coil motif: a new tool for drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e110-1.
2010: Bram Slütter; Wim Jiskoot
Dual role of CpG as immune modulator and physical crosslinker in ovalbumin loaded N-trimethyl chitosan (TMC) nanoparticles for nasal vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):117-21.
2010: Deepa Mohanan; Bram Slütter; Malou Henriksen-Lacey; Wim Jiskoot; Joke A Bouwstra; Yvonne Perrie; Thomas M Kündig; Bruno Gander; Pål Johansen
Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems.
Journal of controlled release : official journal of the Controlled Release Society 2010;147(3):342-9.
2010: Miranda M C van Beers; Wim Jiskoot; Huub Schellekens
On the role of aggregates in the immunogenicity of recombinant human interferon beta in patients with multiple sclerosis.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010;30(10):767-75.
2010: Başak Kükrer; Vasco Filipe; Esther van Duijn; Piotr T Kasper; Rob Vreeken; Albert J R Heck; Wim Jiskoot
Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.
Pharmaceutical research 2010;27(10):2197-204.
2010: Albert J van Hell; Andrey Klymchenko; Pepijn P Burgers; Ed E. Moret; Wim Jiskoot; Wim E Hennink; Daan J A Crommelin; Enrico Mastrobattista
Conformation and intermolecular interactions of SA2 peptides self-assembled into vesicles.
The journal of physical chemistry. B 2010;114(34):11046-52.
2010: Suzanne M Bal; Zhi Ding; Gideon F A Kersten; Wim Jiskoot; Joke A Bouwstra
Microneedle-based transcutaneous immunisation in mice with N-trimethyl chitosan adjuvanted diphtheria toxoid formulations.
Pharmaceutical research 2010;27(9):1837-47.
2010: Miranda M C van Beers; Melody Sauerborn; Francesca Gilli; Vera Brinks; Huub Schellekens; Wim Jiskoot
Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice.
Pharmaceutical research 2010;27(9):1812-24.
2010: Bram Slütter; Suzanne Bal; Chantal Keijzer; Roel Mallants; Niels Hagenaars; Ivo Que; Eric Kaijzel; Willem van Eden; Patrick Augustijns; Clemens W G M Löwik; Joke Bouwstra; Femke Broere; Wim Jiskoot
Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen.
Vaccine 2010;28(38):6282-91.
2010: Tue Rasmussen; Ruedeeporn Tantipolphan; Marco van de Weert; Wim Jiskoot
The molecular chaperone alpha-crystallin as an excipient in an insulin formulation.
Pharmaceutical research 2010;27(7):1337-47.
2010: Ruedeeporn Tantipolphan; Stefan Romeijn; John den Engelsman; Riccardo Torosantucci; Tue Rasmussen; Wim Jiskoot
Elution behavior of insulin on high-performance size exclusion chromatography at neutral pH.
Journal of pharmaceutical and biomedical analysis 2010;52(2):195-202.
2010: Andrea Hawe; Robert Poole; Wim Jiskoot
Misconceptions over Förster resonance energy transfer between proteins and ANS/bis-ANS: Direct excitation dominates dye fluorescence.
Analytical biochemistry 2010;401(1):99-106.
2010: Niels Hagenaars; Marta Mania; Pascal de Jong; Ivo Que; Rob Nieuwland; Bram Slütter; Harrie L Glansbeek; Jacco Heldens; H van den Bosch; Clemens Löwik; Eric Kaijzel; Enrico Mastrobattista; Wim Jiskoot
Role of trimethylated chitosan (TMC) in nasal residence time, local distribution and toxicity of an intranasal influenza vaccine.
Journal of controlled release : official journal of the Controlled Release Society 2010;144(1):17-24.
2010: Vasco Filipe; Andrea Hawe; Wim Jiskoot
Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates.
Pharmaceutical research 2010;27(5):796-810.
2010: John F Carpenter; Theodore W Randolph; Wim Jiskoot; Daan J A Crommelin; C Russell Middaugh; Gerhard Winter
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products.
Journal of pharmaceutical sciences 2010;99(5):2200-8.
2010: Bram Slütter; Peter Christiaan Soema; Zhi Ding; Rolf Verheul; Wim Hennink; Wim Jiskoot
Conjugation of ovalbumin to trimethyl chitosan improves immunogenicity of the antigen.
Journal of controlled release : official journal of the Controlled Release Society 2010;143(2):207-14.
2010: Hana Robson Marsden; Christophe Barnier Quer; Eduardo Y Sanchez; Luca Gabrielli; Wim Jiskoot; Alexander Kros
Detergent-aided polymersome preparation.
Biomacromolecules 2010;11(4):833-8.
2010: Suzanne M Bal; Bram Slütter; Elly van Riet; Annelieke C Kruithof; Zhi Ding; Gideon F A Kersten; Wim Jiskoot; Joke A Bouwstra
Efficient induction of immune responses through intradermal vaccination with N-trimethyl chitosan containing antigen formulations.
Journal of controlled release : official journal of the Controlled Release Society 2010;142(3):374-83.
2010: Andrea Hawe; Vasco Filipe; Wim Jiskoot
Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations.
Pharmaceutical research 2010;27(2):314-26.
2010: Melody Sauerborn; Vera Brinks; Wim Jiskoot; Huub Schellekens
Immunological mechanism underlying the immune response to recombinant human protein therapeutics.
Trends in pharmacological sciences 2010;31(2):53-9.
2010: Maryam Amidi; Enrico Mastrobattista; Wim Jiskoot; Wim E Hennink
Chitosan-based delivery systems for protein therapeutics and antigens.
Advanced drug delivery reviews 2010;62(1):59-82.
2010: Miranda M C van Beers; Melody Sauerborn; Francesca Gilli; Suzanne Hermeling; Vera Brinks; Huub Schellekens; Wim Jiskoot
Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta.
Journal of immunological methods 2010;352(1-2):32-7.
2009: Niels Hagenaars; Rolf J Verheul; Imke Mooren; Pascal H J L F de Jong; Enrico Mastrobattista; Harrie L Glansbeek; Jacco G M Heldens; H van den Bosch; Wim E Hennink; Wim Jiskoot
Relationship between structure and adjuvanticity of N,N,N-trimethyl chitosan (TMC) structural variants in a nasal influenza vaccine.
Journal of controlled release : official journal of the Controlled Release Society 2009;140(2):126-33.
2009: Tue Rasmussen; Marina R Kasimova; Wim Jiskoot; Marco van de Weert
The chaperone-like protein alpha-crystallin dissociates insulin dimers and hexamers.
Biochemistry 2009;48(39):9313-20.
2009: Andrea Hawe; Julia Kasper; Wolfgang Friess; Wim Jiskoot
Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;38(2):79-87.
2009: Bram Slütter; Laurence Plapied; Virgine Fievez; Maria Alonso Sande; Anne des Rieux; Yves-Jacques Schneider; Elly Van Riet; Wim Jiskoot; Véronique Préat
Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2009;138(2):113-21.
2009: A H Ghassemi; Mies J van Steenbergen; Herre Talsma; Cornelus F van Nostrum; Wim Jiskoot; D J A Crommelin; Wim E Hennink
Preparation and characterization of protein loaded microspheres based on a hydroxylated aliphatic polyester, poly(lactic-co-hydroxymethyl glycolic acid).
Journal of controlled release : official journal of the Controlled Release Society 2009;138(1):57-63.
2009: Andrea Hawe; Robert Poole; Stefan G Romeijn; Piotr Kasper; Rob van der Heijden; Wim Jiskoot
Towards heat-stable oxytocin formulations: analysis of degradation kinetics and identification of degradation products.
Pharmaceutical research 2009;26(7):1679-88.
2009: Zhi Ding; E Van Riet; Stefan G Romeijn; Gideon F A Kersten; Wim Jiskoot; Joke A Bouwstra
Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB/c mice after microneedle array pretreatment.
Pharmaceutical research 2009;26(7):1635-43.
2009: Rolf J Verheul; Maryam Amidi; Mies J van Steenbergen; Elly van Riet; Wim Jiskoot; Wim E Hennink
Influence of the degree of acetylation on the enzymatic degradation and in vitro biological properties of trimethylated chitosans.
Biomaterials 2009;30(18):3129-35.
2009: Wim Jiskoot; Rianne M F van Schie; Myrra G Carstens; Huub Schellekens
Immunological risk of injectable drug delivery systems.
Pharmaceutical research 2009;26(6):1303-14.
2009: Niels Hagenaars; Enrico Mastrobattista; Rolf J Verheul; Imke Mooren; Harrie L Glansbeek; Jacco G M Heldens; H van den Bosch; Wim Jiskoot
Physicochemical and immunological characterization of N,N,N-trimethyl chitosan-coated whole inactivated influenza virus vaccine for intranasal administration.
Pharmaceutical research 2009;26(6):1353-64.
2009: John F Carpenter; Theodore W Randolph; Wim Jiskoot; Daan J A Crommelin; C Russell Middaugh; Gerhard Winter; Ying-Xin Fan; Susan Kirshner; Daniela Verthelyi; Steven Kozlowski; Kathleen A Clouse; Patrick G Swann; Amy Rosenberg; Barry Cherney
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.
Journal of pharmaceutical sciences 2009;98(4):1201-5.
2008: Niels Hagenaars; Enrico Mastrobattista; Harrie Glansbeek; Jacco Heldens; H van den Bosch; Virgil E J C Schijns; Didier Betbeder; Herman Vromans; Wim Jiskoot
Head-to-head comparison of four nonadjuvanted inactivated cell culture-derived influenza vaccines: effect of composition, spatial organization and immunization route on the immunogenicity in a murine challenge model.
Vaccine 2008;26(51):6555-63.
2008: Rolf J Verheul; Maryam Amidi; Steffen van der Wal; Elly van Riet; Wim Jiskoot; Wim E Hennink
Synthesis, characterization and in vitro biological properties of O-methyl free N,N,N-trimethylated chitosan.
Biomaterials 2008;29(27):3642-9.
2008: Andréanne Bouchard; Natasa Jovanović; Anne H de Boer; Angel Martín; Wim Jiskoot; Daan J A Crommelin; Gerard W Hofland; Geert-Jan Witkamp
Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;70(1):389-401.
2008: Zhi Ding; Maytal Bivas-Benita; Hoang Hirschberg; Gideon F A Kersten; Wim Jiskoot; Joke A Bouwstra
Preparation and characterization of diphtheria toxoid-loaded elastic vesicles for transcutaneous immunization.
Journal of drug targeting 2008;16(7):555-63.
2008: Francesca Gilli; Miranda van Beers; Fabiana Marnetto; Wim Jiskoot; Antonio Bertolotto; Huub Schellekens
Development of a bioassay for quantification of neutralising antibodies against human interferon-beta in mouse sera.
Journal of immunological methods 2008;336(2):119-26.
2008: Andrea Hawe; Wolfgang Friess; Marc Sutter; Wim Jiskoot
Online fluorescent dye detection method for the characterization of immunoglobulin G aggregation by size exclusion chromatography and asymmetrical flow field flow fractionation.
Analytical biochemistry 2008;378(2):115-22.
2008: Andrea Hawe; Marc Sutter; Wim Jiskoot
Extrinsic fluorescent dyes as tools for protein characterization.
Pharmaceutical research 2008;25(7):1487-99.
2008: Maryam Amidi; Kevin M Krudys; Cor J Snel; Daan J A Crommelin; Oscar Della-Pasqua; Wim E Hennink; Wim Jiskoot
Efficacy of pulmonary insulin delivery in diabetic rats: use of a model-based approach in the evaluation of insulin powder formulations.
Journal of controlled release : official journal of the Controlled Release Society 2008;127(3):257-66.
2008: Andréanne Bouchard; Natasa Jovanović; Gerard W Hofland; Wim Jiskoot; Eduardo Mendes; Daan J A Crommelin; Geert-Jan Witkamp
Supercritical fluid drying of carbohydrates: selection of suitable excipients and process conditions.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(3):781-94.
2008: Maryam Amidi; Hubert C Pellikaan; Anne H de Boer; Daan J A Crommelin; Wim E Hennink; Wim Jiskoot
Preparation and physicochemical characterization of supercritically dried insulin-loaded microparticles for pulmonary delivery.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):191-200.
2008: Natasa Jovanović; Andréanne Bouchard; Gerard W Hofland; Geert-Jan Witkamp; Daan J A Crommelin; Wim Jiskoot
Stabilization of IgG by supercritical fluid drying: optimization of formulation and process parameters.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(2):183-90.
2008: Natasa Jovanović; Andréanne Bouchard; Marc Sutter; Michiel Van Speybroeck; Gerard W Hofland; Geert-Jan Witkamp; Daan J A Crommelin; Wim Jiskoot
Stable sugar-based protein formulations by supercritical fluid drying.
International journal of pharmaceutics 2008;346(1-2):102-8.
2008: Bram Slütter; Niels Hagenaars; Wim Jiskoot
Rational design of nasal vaccines.
Journal of drug targeting 2008;16(1):1-17.
2007: Marjan M Fretz; Anders Høgset; Gerben A Koning; Wim Jiskoot; Gert Storm
Cytosolic delivery of liposomally targeted proteins induced by photochemical internalization.
Pharmaceutical research 2007;24(11):2040-7.
2007: K D F Vlugt-Wensink; Y J Meijer; Mies J van Steenbergen; Ruud Verrijk; Wim Jiskoot; Daan J A Crommelin; Wim E Hennink
Effect of excipients on the encapsulation efficiency and release of human growth hormone from dextran microspheres.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2007;67(3):589-96.
2007: Bernard Metz; Wim Jiskoot; Dirk Mekkes; Robert Kingma; Wim E Hennink; Daan J A Crommelin; Gideon F A Kersten
Quality control of routine, experimental and real-time aged diphtheria toxoids by in vitro analytical techniques.
Vaccine 2007;25(39-40):6863-71.
2007: Maryam Amidi; Hubert C Pellikaan; Hoang Hirschberg; Anne H de Boer; Daan J A Crommelin; Wim E Hennink; Gideon F A Kersten; Wim Jiskoot
Diphtheria toxoid-containing microparticulate powder formulations for pulmonary vaccination: preparation, characterization and evaluation in guinea pigs.
Vaccine 2007;25(37-38):6818-29.
2007: Albert J van Hell; Cristina I C A Costa; Frits M Flesch; Marc Sutter; Wim Jiskoot; Daan J A Crommelin; Wim E Hennink; Enrico Mastrobattista
Self-assembly of recombinant amphiphilic oligopeptides into vesicles.
Biomacromolecules 2007;8(9):2753-61.
2007: Marien I de Jonge; Gérard Pehau-Arnaudet; Marjan M Fretz; Felix Romain; Daria Bottai; Priscille Brodin; Nadine Honoré; Gilles Marchal; Wim Jiskoot; Patrick England; Stewart T Cole; Roland Brosch
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity.
Journal of bacteriology 2007;189(16):6028-34.
2007: Marc Sutter; Juergen Siepmann; Wim E Hennink; Wim Jiskoot
Recombinant gelatin hydrogels for the sustained release of proteins.
Journal of controlled release : official journal of the Controlled Release Society 2007;119(3):301-12.
2007: Bernard Metz; Florence Brunel; Catherine Chamberlin; Johan van der Gun; Marlies Halder; Wim Jiskoot; Gideon F A Kersten; Omer van Opstal; Jesper W Petersen; Satish D Ravetkar; Keith Redhead; Michael Schwanig; Ellen Sloth Wilhelmsen; Willie F Vann; Coenraad F M Hendriksen
The potential of physicochemical and immunochemical assays to replace animal tests in the quality control of toxoid vaccines. The report and recommendations of ECVAM workshop 61.
Alternatives to laboratory animals : ATLA 2007;35(3):323-31.
2007: Marc Sutter; Sabrina Oliveira; Niek N Sanders; Bart Lucas; Arie van Hoek; Mark A Hink; Antonie J W G Visser; Stefaan C De Smedt; Wim E Hennink; Wim Jiskoot
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red.
Journal of fluorescence 2007;17(2):181-92.
2007: Coen Maas; Suzanne Hermeling; Barend Bouma; Wim Jiskoot; Martijn F B G Gebbink
A role for protein misfolding in immunogenicity of biopharmaceuticals.
The Journal of biological chemistry 2007;282(4):2229-36.
2007: Maryam Amidi; Stefan G Romeijn; Jan Verhoef; Hans E Junginger; Laura Bungener; Anke Huckriede; Daan J A Crommelin; Wim Jiskoot
N-trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model.
Vaccine 2007;25(1):144-53.
2007: Gerrit S Zijlstra; Michiel Rijkeboer; Dirk Jan van Drooge; Marc Sutter; Wim Jiskoot; Marco van de Weert; W L J Hinrichs; Henderik W Frijlink
Characterization of a cyclosporine solid dispersion for inhalation.
The AAPS journal 2007;9(2):E190-9.
2006: K D F Vlugt-Wensink; Xulin Jiang; Geert Schotman; Govert Kruijtzer; Arjen Vredenberg; Jin T Chung; Zhibing Zhang; Cees Versluis; Delphine Ramos; Ruud Verrijk; Wim Jiskoot; Daan J A Crommelin; Wim E Hennink
In vitro degradation behavior of microspheres based on cross-linked dextran.
Biomacromolecules 2006;7(11):2983-90.
2006: Huub Schellekens; Wim Jiskoot
Erythropoietin-Associated PRCA: Still an Unsolved Mystery.
Journal of immunotoxicology 2006;3(3):123-30.
2006: Natasa Jovanović; Ad Gerich; Andréanne Bouchard; Wim Jiskoot
Near-infrared imaging for studying homogeneity of protein-sugar mixtures.
Pharmaceutical research 2006;23(9):2002-13.
2006: Aissa Ramzi; Marc Sutter; Wim E Hennink; Wim Jiskoot
Static light scattering and small-angle neutron scattering study on aggregated recombinant gelatin in aqueous solution.
Journal of pharmaceutical sciences 2006;95(8):1703-11.
2006: Huub Schellekens; Wim Jiskoot
Eprex-associated pure red cell aplasia and leachates.
Nature biotechnology 2006;24(6):613-4.
2006: Bernard Metz; Gideon F A Kersten; Gino J E Baart; Annemieke de Jong; Hugo D Meiring; Jan ten Hove; Mies J van Steenbergen; Wim E Hennink; Daan J A Crommelin; Wim Jiskoot
Identification of formaldehyde-induced modifications in proteins: reactions with insulin.
Bioconjugate chemistry 2006;17(3):815-22.
2006: Suzanne Hermeling; Huub Schellekens; Coen Maas; Martijn F B G Gebbink; Daan J A Crommelin; Wim Jiskoot
Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation.
Journal of pharmaceutical sciences 2006;95(5):1084-96.
2006: K D F Vlugt-Wensink; Thijs J H Vlugt; Wim Jiskoot; Daan J A Crommelin; Ruud Verrijk; Wim E Hennink
Modeling the release of proteins from degrading crosslinked dextran microspheres using kinetic Monte Carlo simulations.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):117-27.
2006: Maryam Amidi; Stefan G Romeijn; Gerrit Borchard; Hans E Junginger; Wim E Hennink; Wim Jiskoot
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(1-2):107-16.
2006: Suzanne Hermeling; Wim Jiskoot; Daan J A Crommelin; Huub Schellekens
Reaction to the paper: interaction of polysorbate 80 with erythropoietin: a case study in protein-surfactant interactions.
Pharmaceutical research 2006;23(3):641-2; author reply 643-4.
2006: Natasa Jovanović; Andréanne Bouchard; Gerard W Hofland; Geert-Jan Witkamp; Daan J A Crommelin; Wim Jiskoot
Distinct effects of sucrose and trehalose on protein stability during supercritical fluid drying and freeze-drying.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;27(4):336-45.
2005: Suzanne Hermeling; Liliana Aranha; J Mirjam A Damen; Monique Slijper; Huub Schellekens; Daan J A Crommelin; Wim Jiskoot
Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b.
Pharmaceutical research 2005;22(12):1997-2006.
2005: Yixian Zhao; Yair Benita; Martin C Lok; Betsy Kuipers; Peter van der Ley; Wim Jiskoot; Wim E Hennink; Daan J A Crommelin; Ronald S Oosting
Multi-antigen immunization using IgG binding domain ZZ as carrier.
Vaccine 2005;23(43):5082-90.
2005: Carmen Arigita; Thomas Luijkx; Wim Jiskoot; Martien C M Poelen; Wim E Hennink; Daan J A Crommelin; Peter van der Ley; Cecile Van Els; Gideon F A Kersten
Well-defined and potent liposomal meningococcal B vaccines adjuvated with LPS derivatives.
Vaccine 2005;23(43):5091-8.
2005: Marjan M Fretz; Enrico Mastrobattista; Gerben A Koning; Wim Jiskoot; Gert Storm
Strategies for cytosolic delivery of liposomal macromolecules.
International journal of pharmaceutics 2005;298(2):305-9.
2005: Dion M A M Luykx; S S Goerdayal; P J Dingemanse; Wim Jiskoot; Peter M J M Jongen
HPLC and tandem detection to monitor conformational properties of biopharmaceuticals.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;821(1):45-52.
2005: Suzanne Hermeling; Wim Jiskoot; Daan J A Crommelin; Claus Bornaes; Huub Schellekens
Development of a transgenic mouse model immune tolerant for human interferon Beta.
Pharmaceutical research 2005;22(6):847-51.
2004: Wim Jiskoot; Patrizia Santi
Innovative therapeutics: from molecules to medicines. 27 June-7 July 2004, Parma, Italy.
Expert opinion on drug delivery 2004;1(1):185-90.
2004: Natasa Jovanović; Andréanne Bouchard; Gerard W Hofland; Geert-Jan Witkamp; Daan J A Crommelin; Wim Jiskoot
Stabilization of proteins in dry powder formulations using supercritical fluid technology.
Pharmaceutical research 2004;21(11):1955-69.
2004: Marjan M Fretz; Gerben A Koning; Enrico Mastrobattista; Wim Jiskoot; Gert Storm
OVCAR-3 cells internalize TAT-peptide modified liposomes by endocytosis.
Biochimica et biophysica acta 2004;1665(1-2):48-56.
2004: Marien I de Jonge; Hendrik-Jan Hamstra; Wim Jiskoot; Paul Roholl; Neil A Williams; Jacob Dankert; Loek van Alphen; Peter van der Ley
Intranasal immunisation of mice with liposomes containing recombinant meningococcal OpaB and OpaJ proteins.
Vaccine 2004;22(29-30):4021-8.
2004: Dion M A M Luykx; Marco G Casteleijn; Wim Jiskoot; Janny Westdijk; Peter M J M Jongen
Physicochemical studies on the stability of influenza haemagglutinin in vaccine bulk material.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;23(1):65-75.
2004: Atthachai Homhuan; Sompol Prakongpan; Prachak Poomvises; Riks A Maas; Daan J A Crommelin; Gideon F A Kersten; Wim Jiskoot
Virosome and ISCOM vaccines against Newcastle disease: preparation, characterization and immunogenicity.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;22(5):459-68.
2004: Suzanne Hermeling; Daan J A Crommelin; Huub Schellekens; Wim Jiskoot
Structure-immunogenicity relationships of therapeutic proteins.
Pharmaceutical research 2004;21(6):897-903.
2004: Camilla Foged; Carmen Arigita; Anne Sundblad; Wim Jiskoot; Gert Storm; Sven Frokjaer
Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition.
Vaccine 2004;22(15-16):1903-13.
2004: Ewald T J van den Bremer; Anthony H Keeble; Wim Jiskoot; Robin E J Spelbrink; Claudia S Maier; Arie van Hoek; Antonie J W G Visser; Richard James; Geoffrey R Moore; Colin Kleanthous; albert heck
Distinct conformational stability and functional activity of four highly homologous endonuclease colicins.
Protein science : a publication of the Protein Society 2004;13(5):1391-401.
2004: Ewald T J van den Bremer; Anthony H Keeble; Antonie J W G Visser; Arie van Hoek; Colin Kleanthous; albert heck; Wim Jiskoot
Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease.
Biochemistry 2004;43(14):4347-55.
2004: Bernard Metz; Gideon F A Kersten; Peter Hoogerhout; Humphrey F Brugghe; hans timmermans; Annemieke de Jong; Hugo D Meiring; Jan ten Hove; Wim E Hennink; Daan J A Crommelin; Wim Jiskoot
Identification of formaldehyde-induced modifications in proteins: reactions with model peptides.
The Journal of biological chemistry 2004;279(8):6235-43.
2004: Carmen Arigita; Joost van den Berg; Karin Wensink; Mies J van Steenbergen; Wim E Hennink; Daan J A Crommelin; Gideon F A Kersten; Wim Jiskoot
Immunogenicity of meningococcal PorA formulations encapsulated in biodegradable microspheres.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2004;21(2-3):131-41.
2004: Carmen Arigita; Wim Jiskoot; Janny Westdijk; Cor van Ingen; Wim E Hennink; Daan J A Crommelin; Gideon F A Kersten
Stability of mono- and trivalent meningococcal outer membrane vesicle vaccines.
Vaccine 2004;22(5-6):629-42.
2003: Bernard Metz; Wim Jiskoot; Wim E Hennink; Daan J A Crommelin; Gideon F A Kersten
Physicochemical and immunochemical techniques predict the quality of diphtheria toxoid vaccines.
Vaccine 2003;22(2):156-67.
2003: Suzanne Hermeling; Huub Schellekens; Daan J A Crommelin; Wim Jiskoot
Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity?
Pharmaceutical research 2003;20(12):1903-7.
2003: Daan J A Crommelin; Gert Storm; Ruud Verrijk; Leo de Leede; Wim Jiskoot; Wim E Hennink
Shifting paradigms: biopharmaceuticals versus low molecular weight drugs.
International journal of pharmaceutics 2003;266(1-2):3-16.
2003: Carmen Arigita; Lisette Bevaart; Linda A Everse; Gerben A Koning; Wim E Hennink; Daan J A Crommelin; Jan G J van de Winkel; Martine J van Vugt; Gideon F A Kersten; Wim Jiskoot
Liposomal meningococcal B vaccination: role of dendritic cell targeting in the development of a protective immune response.
Infection and immunity 2003;71(9):5210-8.
2003: Daan J A Crommelin; Gert Storm; Wim Jiskoot; Robert Stenekes; Enrico Mastrobattista; Wim E Hennink
Nanotechnological approaches for the delivery of macromolecules.
Journal of controlled release : official journal of the Controlled Release Society 2003;87(1-3):81-8.
2003: Carmen Arigita; Gideon F A Kersten; Ton Hazendonk; Wim E Hennink; Daan J A Crommelin; Wim Jiskoot
Restored functional immunogenicity of purified meningococcal PorA by incorporation into liposomes.
Vaccine 2003;21(9-10):950-60.
2002: Marien I de Jonge; Martine P Bos; Hendrik-Jan Hamstra; Wim Jiskoot; Peter van Ulsen; Jan Tommassen; Loek van Alphen; Peter van der Ley
Conformational analysis of opacity proteins from Neisseria meningitidis.
European journal of biochemistry / FEBS 2002;269(21):5215-23.
2002: Enrico Mastrobattista; Gerben A Koning; Louis van Bloois; Ana C S Filipe; Wim Jiskoot; Gert Storm
Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins.
The Journal of biological chemistry 2002;277(30):27135-43.
2002: Ewald T J van den Bremer; Wim Jiskoot; Richard James; Geoffrey R Moore; Colin Kleanthous; albert heck; Claudia S Maier
Probing metal ion binding and conformational properties of the colicin E9 endonuclease by electrospray ionization time-of-flight mass spectrometry.
Protein science : a publication of the Protein Society 2002;11(7):1738-52.
2002: Bernard Metz; Coenraad F M Hendriksen; Wim Jiskoot; Gideon F A Kersten
Reduction of animal use in human vaccine quality control: opportunities and problems.
Vaccine 2002;20(19-20):2411-30.
2002: Jenny A Cadée; Cornelis J De Groot; Wim Jiskoot; Willem Den Otter; Wim E Hennink
Release of recombinant human interleukin-2 from dextran-based hydrogels.
Journal of controlled release : official journal of the Controlled Release Society 2002;78(1-3):1-13.
2001: Jenny A Cadée; Mies J van Steenbergen; Cees Versluis; albert heck; Willy J M Underberg; Willem Den Otter; Wim Jiskoot; Wim E Hennink
Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate.
Pharmaceutical research 2001;18(10):1461-7.
2001: Carmen Arigita; Wim Jiskoot; M R Graaf; Gideon F A Kersten
Outer membrane protein purification.
Methods in molecular medicine 2001;66():61-79.
2000: Gert Bos; A Trullas-Jimeno; Wim Jiskoot; Daan J A Crommelin; Wim E Hennink
Sterilization of poly(dimethylamino) ethyl methacrylate-based gene transfer complexes.
International journal of pharmaceutics 2000;211(1-2):79-88.
2000: ML van Slooten; Antonie J W G Visser; A van Hoek; Gert Storm; Daan J A Crommelin; Wim Jiskoot
Conformational stability of human interferon-gamma on association with and dissociation from liposomes.
Journal of pharmaceutical sciences 2000;89(12):1605-19.
2000: Marco van de Weert; Wim E Hennink; Wim Jiskoot
Protein instability in poly(lactic-co-glycolic acid) microparticles.
Pharmaceutical research 2000;17(10):1159-67.
1999: Peter Hoogerhout; Koert J Stittelaar; Humphrey F Brugghe; hans timmermans; G J ten Hove; Wim Jiskoot; Jan H G Hoekman; Paul Roholl
Solid-phase synthesis and application of double-fluorescent-labeled lipopeptides, containing a CTL-epitope from the measles fusion protein.
The journal of peptide research : official journal of the American Peptide Society 1999;54(5):436-43.
1999: Marcel Thalen; Jan van den IJssel; Wim Jiskoot; Bert Zomer; Paul Roholl; CD de Gooijer; Coen Beuvery; Johannes Tramper
Rational medium design for Bordetella pertussis: basic metabolism.
Journal of biotechnology 1999;75(2-3):147-59.
1999: JY Cherng; Nancy M E Schuurmans-Nieuwenbroek; Wim Jiskoot; Herre Talsma; NJ Zuidam; Wim E Hennink; Daan J A Crommelin
Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(2-3):343-53.
1998: Gideon F A Kersten; Wim Jiskoot; Ton Hazendonk; E C Beuvery
In vitro determination of antigen quality: biosensor analysis and fluorescence spectroscopy.
Developments in biological standardization 1998;92():295-300.
1997: Jean van den Elsen; L M van Unen; Louis van Bloois; M A Busquets; Wim Jiskoot; Peter Hoogerhout; J Wilting; JN Herron; Daan J A Crommelin
Thermodynamic analysis of the interaction between a bactericidal antibody and a PorA epitope of Neisseria meningitidis.
Biochemistry 1997;36(41):12583-91.
1997: Janny Westdijk; Jan van den IJssel; Marcel Thalen; Coen Beuvery; Wim Jiskoot
Quantification of cell-associated and free antigens in Bordetella pertussis suspensions by antigen binding ELISA.
Journal of immunoassay 1997;18(3):267-84.
1996: K Yoneto; S Kevin Li; William I Higuchi; Wim Jiskoot; J N Herron
Fluorescent probe studies of the interactions of 1-alkyl-2-pyrrolidones with stratum corneum lipid liposomes.
Journal of pharmaceutical sciences 1996;85(5):511-7.
1996: Wim Jiskoot; J Westdijk; C H Reubsaet; E C Beuvery
Analysis of Bordetella pertussis suspensions by ELISA and flow cytometry.
Advances in experimental medicine and biology 1996;397():153-7.
1995: Wim Jiskoot; Vladimir Hlady; J J Naleway; J N Herron
Application of fluorescence spectroscopy for determining the structure and function of proteins.
Pharmaceutical biotechnology 1995;7():1-63.
1993: V Omelyanenko; Wim Jiskoot; J N Herron
Role of electrostatic interactions in the binding of fluorescein by anti-fluorescein antibody 4-4-20.
Biochemistry 1993;32(39):10423-9.
1992: Wim Jiskoot; G van de Werken; J M Martin; B N Green; E C Beuvery; Daan J A Crommelin
Application of electrospray mass spectrometry (ES-MS) for the analysis of monoclonal antibody Fc subunits.
Pharmaceutical research 1992;9(7):945-51.
1992: B van Haeringen; Wim Jiskoot; Rienk van Grondelle; M Bloemendal
Acid-induced structural changes of a mouse IgG2a monoclonal antibody (MN12) studied by transient electric birefringence measurement.
Journal of biomolecular structure & dynamics 1992;9(5):991-1011.
1992: M E Ressing; Wim Jiskoot; Herre Talsma; C W van Ingen; E C Beuvery; Daan J A Crommelin
The influence of sucrose, dextran, and hydroxypropyl-beta-cyclodextrin as lyoprotectants for a freeze-dried mouse IgG2a monoclonal antibody (MN12).
Pharmaceutical research 1992;9(2):266-70.
1991: Wim Jiskoot; M Bloemendal; B van Haeringen; Rienk van Grondelle; E C Beuvery; J N Herron; Daan J A Crommelin
Non-random conformation of a mouse IgG2a monoclonal antibody at low pH.
European journal of biochemistry / FEBS 1991;201(1):223-32.
1991: Wim Jiskoot; Peter Hoogerhout; E C Beuvery; J N Herron; Daan J A Crommelin
Preparation and application of a fluorescein-labeled peptide for determining the affinity constant of a monoclonal antibody-hapten complex by fluorescence polarization.
Analytical biochemistry 1991;196(2):421-6.
1991: Wim Jiskoot; J J Van Hertrooij; A M Hoven; J W Klein Gebbinck; T Van der Velden-de Groot; Daan J A Crommelin; E C Beuvery
Preparation of clinical grade monoclonal antibodies from serum-containing cell culture supernatants.
Journal of immunological methods 1991;138(2):273-83.
1991: Wim Jiskoot; A M Hoven; A A De Koning; M F Leerling; C H Reubsaet; Daan J A Crommelin; E C Beuvery
Purification and stabilisation of a poorly soluble mouse IgG3 monoclonal antibody.
Journal of immunological methods 1991;138(2):181-9.
1990: Wim Jiskoot; E C Beuvery; A A de Koning; J N Herron; Daan J A Crommelin
Analytical approaches to the study of monoclonal antibody stability.
Pharmaceutical research 1990;7(12):1234-41.
1990: Wim Jiskoot; J W Gebbinck; J J van Hertrooij; T van der Velden-de Groot; Daan J A Crommelin; E C Beuvery
A purification strategy for the production of clinical grade monoclonal antibodies.
Developments in biological standardization 1990;71():73-8.
1989: Wim Jiskoot; J J Van Hertrooij; J W Klein Gebbinck; T Van der Velden-de Groot; Daan J A Crommelin; E C Beuvery
Two-step purification of a murine monoclonal antibody intended for therapeutic application in man. Optimisation of purification conditions and scaling up.
Journal of immunological methods 1989;124(1):143-56.
1986: Wim Jiskoot; T Teerlink; M M Van Hoof; K Bartels; V Kanhai; Daan J A Crommelin; E C Beuvery
Immunogenic activity of gonococcal protein I in mice with three different lipoidal adjuvants delivered in liposomes and in complexes.
Infection and immunity 1986;54(2):333-8.
1986: Wim Jiskoot; T Teerlink; E C Beuvery; Daniel Crommelin
Preparation of liposomes via detergent removal from mixed micelles by dilution. The effect of bilayer composition and process parameters on liposome characteristics.
Pharmaceutisch weekblad. Scientific edition 1986;8(5):259-65.