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Karin Pike-Overzet

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Harald Mikkers; Karin Pike-Overzet; Frank Staal
Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?
Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Rudi W Hendriks; Karin Pike-Overzet; Robbert Gm Bredius; Frank Staal
Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.

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All Publications

2012: Harald Mikkers; Karin Pike-Overzet; Frank Staal
Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?
Pediatric research 2012;71(4 Pt 2):427-32.
2011: Karin Pike-Overzet; M Rodijk; A Schambach; Adrian J Thrasher; J J M van Dongen; F Zhang; M R M Baert; Christopher Baum; R G M Bredius; M Cavazzana-Calvo; G J A Driessen; Salima Hacein-Bey-Abina; Rob Hoeben; C Lagresle-Peyrou; Arjan C Lankester; Yuk Yin Ng; Frank Staal
Correction of murine Rag1 deficiency by self-inactivating lentiviral vector-mediated gene transfer.
Leukemia 2011;25(9):1471-83.
2011: Rudi W Hendriks; Karin Pike-Overzet; Robbert Gm Bredius; Frank Staal
Biology and novel treatment options for XLA, the most common monogenetic immunodeficiency in man.
Expert opinion on therapeutic targets 2011;15(8):1003-21.
2011: Irene Homminga; Rob Pieters; Anton W Langerak; Johan J de Rooi; Andrew Stubbs; Monique Verstegen; Maartje Vuerhard; Jessica Buijs-Gladdines; Clarissa Kooi; Petra Klous; Pieter Van Vlierberghe; Adolfo Ferrando; Jean Michel Cayuela; Brenda Verhaaf; Berna Beverloo; Martin Horstmann; Valerie de Haas; Anna-Sophia Wiekmeijer; Karin Pike-Overzet; Frank Staal; Wouter de Laat; Jean Soulier; Francois Sigaux; Jules P P Meijerink
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia.
Cancer cell 2011;19(4):484-97.
2010: Yuk Yin Ng; M R M Baert; Karin Pike-Overzet; M Rodijk; Martijn Brugman; A Schambach; C Baum; Rudolf W Hendriks; J J M van Dongen; Frank Staal
Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.
Leukemia 2010;24(9):1617-30.
2009: Karin Pike-Overzet; Dick de Ridder; Tom Schonewille; Frank Staal
DNA microarray studies of hematopoietic subpopulations.
Methods in molecular biology (Clifton, N.J.) 2009;506():403-21.
2009: Yuk Yin Ng; Miranda Baert; Edwin F E de Haas; Karin Pike-Overzet; Frank Staal
Isolation of human and mouse hematopoietic stem cells.
Methods in molecular biology (Clifton, N.J.) 2009;506():13-21.
2008: Frank Staal; Karin Pike-Overzet; Yuk Yin Ng; Jacques J M van Dongen
Sola dosis facit venenum. Leukemia in gene therapy trials: a question of vectors, inserts and dosage?
Leukemia 2008;22(10):1849-52.
2008: Steven J Howe; Marc R Mansour; Kerstin Schwarzwaelder; Cynthia Bartholomae; Michael Hubank; Helena Kempski; Martijn Brugman; Karin Pike-Overzet; Stephen J Chatters; Dick de Ridder; Kimberly C Gilmour; Stuart Adams; Susannah I Thornhill; Kathryn L Parsley; Frank Staal; Rosemary E Gale; David C Linch; Jinhua Bayford; Lucie Brown; Michelle Quaye; Christine Kinnon; Philip Ancliff; David K Webb; Manfred Schmidt; Christof von Kalle; H Bobby Gaspar; Adrian J Thrasher
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients.
The Journal of clinical investigation 2008;118(9):3143-50.
2007: Karin Pike-Overzet; Mirjam van der Burg; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(11):1910-6.
2007: Kerstin Schwarzwaelder; Steven J Howe; Manfred Schmidt; Martijn Brugman; Annette Deichmann; Hanno Glimm; Sonja Schmidt; Claudia Prinz; Manuela Wissler; Douglas J S King; Fang Zhang; Kathryn L Parsley; Kimberly C Gilmour; Joanna Sinclair; Jinhua Bayford; Rachel Peraj; Karin Pike-Overzet; Frank Staal; Dick de Ridder; Christine Kinnon; Ulrich Abel; Gerard Wagemaker; H Bobby Gaspar; Adrian J Thrasher; Christof von Kalle
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo.
The Journal of clinical investigation 2007;117(8):2241-9.
2007: Annette Deichmann; Salima Hacein-Bey-Abina; Manfred Schmidt; Alexandrine Garrigue; Martijn Brugman; Jingqiong Hu; Hanno Glimm; Gabor Gyapay; Bernard Prum; Christopher C Fraser; Nicolas Fischer; Kerstin Schwarzwaelder; Maria-Luise Siegler; Dick de Ridder; Karin Pike-Overzet; Steven J Howe; Adrian J Thrasher; Gerard Wagemaker; Ulrich Abel; Frank Staal; Eric Delabesse; Jean-Luc Villeval; Bruce Aronow; Christophe Hue; Claudia Prinz; Manuela Wissler; Chuck Klanke; Jean Weissenbach; Ian Alexander; Alain Fischer; Christof von Kalle; Marina Cavazzana-Calvo
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy.
The Journal of clinical investigation 2007;117(8):2225-32.
2007: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; M M A Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.
Leukemia 2007;21(4):754-63.
2007: Olga S Kustikova; Hartmut Geiger; Zhixiong Li; Martijn Brugman; Stuart M Chambers; Chad A Shaw; Karin Pike-Overzet; Dick de Ridder; Frank Staal; Gottfried von Keudell; Kerstin Cornils; Kalpana J Nattamai; Ute Modlich; Gerard Wagemaker; Margaret A Goodell; Boris Fehse; Christopher Baum
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways.
Blood 2007;109(5):1897-907.
2007: Inge Hoebeke; Magda De Smedt; Frank Stolz; Karin Pike-Overzet; Frank Staal; Jean Plum; Georges Leclercq
T-, B- and NK-lymphoid, but not myeloid cells arise from human CD34(+)CD38(-)CD7(+) common lymphoid progenitors expressing lymphoid-specific genes.
Leukemia 2007;21(2):311-9.
2006: Karin Pike-Overzet; Dick de Ridder; Floor Weerkamp; Miranda Baert; Monique M Verstegen; Martijn Brugman; Steven J Howe; Marcel J T Reinders; Adrian J Thrasher; Gerard Wagemaker; Jacques J M van Dongen; Frank Staal
Gene therapy: is IL2RG oncogenic in T-cell development?
Nature 2006;443(7109):E5; discussion E6-7.
2006: Floor Weerkamp; Karin Pike-Overzet; Frank Staal
T-sing progenitors to commit.
Trends in immunology 2006;27(3):125-31.
2005: Willem A Dik; Karin Pike-Overzet; Floor Weerkamp; Dick de Ridder; Edwin F E de Haas; Miranda Baert; Peter van der Spek; Esther E L Koster; Marcel J T Reinders; Jacques J M van Dongen; Anton Langerak; Frank Staal
New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.
The Journal of experimental medicine 2005;201(11):1715-23.
2000: Karin Pike-Overzet; TJ Gensler; S J Kim; M E Geiger; W J van Venrooij; K M Pollard; Paul Anderson; Paul J Utz
Small nucleolar RNP scleroderma autoantigens associate with phosphorylated serine/arginine splicing factors during apoptosis.
Arthritis and rheumatism 2000;43(6):1327-36.