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Ammar Al-Chalabi

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Disorders

Physiology

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Wouter van Rheenen; Paul van Vught; Jan Veldink; Stefan Waibel; Markus Weber; Anneke J van der Kooi; Perry T C van Doormaal; Michael A van Es; Ammar Al-Chalabi; Peter M Andersen; David Czell; Marianne De Visser; Frank P Diekstra; Orla Hardiman; Kevin Kenna; Albert C Ludolph; Russell McLaughlin; Karen E Morrison; Wim Robberecht; H Jurgen Schelhaas; Meinie Seelen; Aleksey Shatunov; Christopher E Shaw; Pamela J Shaw; Bradley N Smith; Philip van Damme; Leonard H Van den Berg
H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.
Lorna J Taylor; Stella Tsermentseli; P Nigel Leigh; Christopher Shaw; Ammar Al-Chalabi; Richard G Brown; CM Ellis; Laura H Goldstein
Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?
Danielle C Diaper; Christopher J H Elliott; Yoshitsugu Adachi; Ammar Al-Chalabi; Patrick Callaerts; Bart Dermaut; Dickon M Humphrey; Zoe N Ludlow; Iain M Robinson; Christopher E Shaw; Alan Stepto; Ben Sutcliffe; Lies Vanden Broeck; Frank Hirth
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.

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2013: Wouter van Rheenen; Paul van Vught; Jan Veldink; Stefan Waibel; Markus Weber; Anneke J van der Kooi; Perry T C van Doormaal; Michael A van Es; Ammar Al-Chalabi; Peter M Andersen; David Czell; Marianne De Visser; Frank P Diekstra; Orla Hardiman; Kevin Kenna; Albert C Ludolph; Russell McLaughlin; Karen E Morrison; Wim Robberecht; H Jurgen Schelhaas; Meinie Seelen; Aleksey Shatunov; Christopher E Shaw; Pamela J Shaw; Bradley N Smith; Philip van Damme; Leonard H Van den Berg
H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.
Neurobiology of aging 2013;34(5):1517.e5-7.
2013: Lorna J Taylor; Stella Tsermentseli; P Nigel Leigh; Christopher Shaw; Ammar Al-Chalabi; Richard G Brown; CM Ellis; Laura H Goldstein
Is language impairment more common than executive dysfunction in amyotrophic lateral sclerosis?
Journal of neurology, neurosurgery, and psychiatry 2013;84(5):494-8.
2013: Danielle C Diaper; Christopher J H Elliott; Yoshitsugu Adachi; Ammar Al-Chalabi; Patrick Callaerts; Bart Dermaut; Dickon M Humphrey; Zoe N Ludlow; Iain M Robinson; Christopher E Shaw; Alan Stepto; Ben Sutcliffe; Lies Vanden Broeck; Frank Hirth
Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.
Human molecular genetics 2013;22(8):1539-57.
2012: Lauren Johnson; Jack W Miller; Stephen J Newhouse; Ammar Al-Chalabi; Athina Soragia Gkazi; Bradley N Smith; Simon D Topp; Caroline Vance; Christopher E Shaw
Screening for OPTN mutations in a cohort of British amyotrophic lateral sclerosis patients.
Neurobiology of aging 2012;33(12):2948.e15-7.
2012: Jack W Miller; Christopher E Shaw; Bradley N Smith; Simon D Topp; Ammar Al-Chalabi; Caroline Vance
Mutation analysis of VCP in British familial and sporadic amyotrophic lateral sclerosis patients.
Neurobiology of aging 2012;33(11):2721.e1-2.
2012: Julia Johnson; P Nigel Leigh; Christopher E Shaw; Rachel Burman; Cathy Ellis; Ammar Al-Chalabi
Eating-derived pleasure in amyotrophic lateral sclerosis as a predictor of non-oral feeding.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2012;13(6):555-9.
2012: William J Scotton; Chris Shaw; Lokesh C Wijesekera; Leeza Almedom; Anna Janssen; Peter N Leigh; Dan H Moore; Catherine Nigro; Mohammed Sakel; Kirsten M Scott; Ammar Al-Chalabi
Prognostic categories for amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2012;13(6):502-8.
2012: Claire Troakes; Caroline Vance; Lokesh Wijesekera; Ammar Al-Chalabi; Christopher Bell; Tibor Hortobágyi; Lauren Johnson; Andrew King; Nigel Leigh; Satomi Maekawa; Stephen Newhouse; Boris Rogelj; Aleksey Shatunov; Christopher Shaw; László Siklós; Bradley Smith; Safa Al-Sarraj
An MND/ALS phenotype associated with C9orf72 repeat expansion: abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline.
Neuropathology : official journal of the Japanese Society of Neuropathology 2012;32(5):505-14.
2012: Annelies Van Hoecke; Paul W van Vught; Jan H Veldink; Ammar Al-Chalabi; Peter M Andersen; Robert H Brown; Bénédicte Dubois; Paloma Gonzalez-Perez; An Goris; Orla Hardiman; Angela S Laird; Robin Lemmens; Elke Peeters; Thomas Philips; Lies Schoonaert; Kim A Staats; Vincent Thijs; Mieke Timmers; Ann M Turnley; Philip Van Damme; Leonard H van den Berg; Ludo Van Den Bosch; Wim Robberecht
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Nature medicine 2012;18(9):1418-22.
2012: Ammar Al-Chalabi; Safa Al-Sarraj; Ashley Jones; Andrew King; Claire Troakes; Leonard H van den Berg
The genetics and neuropathology of amyotrophic lateral sclerosis.
Acta neuropathologica 2012;124(3):339-52.
2012: Olubunmi Abel; Peter M Andersen; John F Powell; Ammar Al-Chalabi
ALSoD: A user-friendly online bioinformatics tool for amyotrophic lateral sclerosis genetics.
Human mutation 2012;33(9):1345-51.
2012: Martin R Turner; Ammar Al-Chalabi; Jessica Barnwell; Andrew Eisen
Young-onset amyotrophic lateral sclerosis: historical and other observations.
Brain : a journal of neurology 2012;135(Pt 9):2883-91.
2012: Inti Pedroso; Marcella Rietschel; Ammar Al-Chalabi; Michael R Barnes; Sven Cichon; Anbarasu Lourdusamy; Peter McGuffin; Markus M Nöthen; Gerome Breen
Common genetic variants and gene-expression changes associated with bipolar disorder are over-represented in brain signaling pathway genes.
Biological psychiatry 2012;72(4):311-7.
2012: Nora S Vyas; Daniel R Stahl; Andrew Ternouth; Kwangmi Ahn; Ammar Al-Chalabi; Yohan Lee; John F Powell; Basant K Puri
Association of a Serotonin Receptor 2A Gene Polymorphism with Visual Sustained Attention in Early-Onset Schizophrenia Patients and their Non-Psychotic Siblings.
Aging and disease 2012;3(4):291-300.
2012: Susan Byrne; Bernie Corr; Marwa Elamin; Ammar Al-Chalabi; Peter Bede; Arun L Bokde; Daniel G Bradley; Mark Heverin; Parameswaran Mahadeva Iyer; Norah Jordan; Kevin Kenna; Catherine Lynch; Russell L McLaughlin; Caoimhe O'Brien; Niall Pender; Julie Phukan; Aleksey Shatunov; Cathal Walsh; Brona Wynne; Orla Hardiman
Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study.
Lancet neurology 2012;11(3):232-40.
2012: Jose C Roche; Ricardo Rojas-Garcia; Kirsten M Scott; William Scotton; Christopher E Shaw; Martin R Turner; Lokesh Wijesekera; Rachel Burman; Catherine E Ellis; P Nigel Leigh; Ammar Al-Chalabi
A proposed staging system for amyotrophic lateral sclerosis.
Brain : a journal of neurology 2012;135(Pt 3):847-52.
2012: Elke Bogaert; Robert H Brown; Peter De Jonghe; Veerle Geelen; Jonathan D Glass; An Goris; John E Landers; Robin Lemmens; Judith Melki; Wim Robberecht; Christopher E Shaw; Kristel Sleegers; Agnieszka Slowik; Vincent Timmerman; Barbara Tomik; Bryan Joseph Traynor; Christine Van Broeckhoven; Philip Van Damme; Leonard H Van den Berg; Ammar Al-Chalabi; Peter M Andersen; Anna Birve; Michael A van Es; Nathalie Verpoorten; Ludo Van Den Bosch
Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis.
Neurobiology of aging 2012;33(2):418-20.
2012: Frank P Diekstra; Karol Estrada; Lude Franke; Ewout J N Groen; Orla Hardiman; Albert Hofman; Steve Horvath; Ritsert C Jansen; John E Landers; P Nigel Leigh; Vincent Meininger; Judith Melki; Roel A Ophoff; Fernando Rivadeneira; Wim Robberecht; Christiaan G J Saris; Aleksey Shatunov; Christopher E Shaw; Andre G Uitterlinden; Leonard H Van den Berg; Michael A van Es; Wouter van Rheenen; Paul van Vught; Ammar Al-Chalabi; Peter M Andersen; Hylke M Blauw; Robert H Brown; Jan Veldink
Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
PloS one 2012;7(4):e35333.
2012: Kin Mok; Gabriele Mora; Huw R Morris; Karen E Morrison; Liisa Myllykangas; Michael A Nalls; Richard W Orrell; Terhi Peuralinna; Stuart Pickering-Brown; Rosa Rademakers; Gabriella Restagno; Pamela Sara Rollinson; Jennifer C Schymick; Aleksey Shatunov; Pamela J Shaw; Javier Simón-Sánchez; Pentti J Tienari; Bryan Joseph Traynor; John C van Swieten; Adrian Waite; Nigel Williams; Ammar Al-Chalabi; Bradley F Boeve; Adam L Boxer; Adriano Chio; Mariely DeJesus-Hernandez; Peter Heutink; Hannu Laaksovirta; Ian R Mackenzie; John Hardy
Chromosome 9 ALS and FTD locus is probably derived from a single founder.
Neurobiology of aging 2012;33(1):209.e3-8.
2011: Safa Al-Sarraj; Istvan Bodi; Tibor Hortobágyi; Andrew King; Satomi Maekawa; Boris Rogelj; Bradley Smith; Claire Troakes; Ammar Al-Chalabi; Christopher Shaw
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS.
Acta neuropathologica 2011;122(6):691-702.
2011: Peter M Andersen; Ammar Al-Chalabi
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
Nature reviews. Neurology 2011;7(11):603-15.
2011: Martin R Turner; Paul Wicks; C A Brownstein; Michael Peter Massagli; Kevin Talbot; M Toronjo; Ammar Al-Chalabi
Concordance between site of onset and limb dominance in amyotrophic lateral sclerosis.
Journal of neurology, neurosurgery, and psychiatry 2011;82(8):853-4.
2011: Christina M Lill; Lars Bertram; Olubunmi Abel; Ammar Al-Chalabi
Keeping up with genetic discoveries in amyotrophic lateral sclerosis: the ALSoD and ALSGene databases.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011;12(4):238-49.
2011: Umesh Vivekananda; Zita-Rose Manjalay; Jeban Ganesalingam; Jacqueline Simms; Christopher Shaw; P Nigel Leigh; Martin R Turner; Ammar Al-Chalabi
Low index-to-ring finger length ratio in sporadic ALS supports prenatally defined motor neuronal vulnerability.
Journal of neurology, neurosurgery, and psychiatry 2011;82(6):635-7.
2011: Isabella Fogh; Sandra D'Alfonso; Cinzia Gellera; Antonia Ratti; Cristina Cereda; Silvana Penco; Lucia Corrado; Gianni Soraru; Barbara Castellotti; Cinzia Tiloca; Stella Gagliardi; Lorena Cozzi; Michelle K Lupton; Nicola Ticozzi; Letizia Mazzini; Chris E Shaw; Ammar Al-Chalabi; John Powell; Vincenzo Silani
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
Neurobiology of aging 2011;32(5):966-7.
2011: Ammar Al-Chalabi; Joanna Kelly; P Nigel Leigh; Karen E Morrison; Caroline Murphy; Pamela J Shaw; I Nicholas Steen; Marie Thornhill; Carolyn A Young
Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic lateral sclerosis (LiCALS) [Eudract number: 2008-006891-31].
BMC neurology 2011;11():111.
2011: Ammar Al-Chalabi; Cathryn M Lewis
Modelling the effects of penetrance and family size on rates of sporadic and familial disease.
Human heredity 2011;71(4):281-8.
2010: Kirsten M Scott; Kumar Abhinav; Lokesh Wijesekera; Jeban Ganesalingam; Laura H Goldstein; Anna Janssen; Andrew Dougherty; Emma Willey; Biba R Stanton; Martin R Turner; Mary-Ann Ampong; Mohammed Sakel; Richard W Orrell; Robin Howard; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
The association between ALS and population density: A population based study.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2010;11(5):435-8.
2010: Zita R Manjaly; Kirsten M Scott; Kumar Abhinav; Lokesh Wijesekera; Jeban Ganesalingam; Laura H Goldstein; Anna Janssen; Andrew Dougherty; Emma Willey; Biba R Stanton; Martin R Turner; Mary-Ann Ampong; Mohammed Sakel; Richard W Orrell; Robin Howard; Chris E Shaw; P Nigel Leigh; Ammar Al-Chalabi
The sex ratio in amyotrophic lateral sclerosis: A population based study.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2010;11(5):439-42.
2010: Alan Rio; C Ellis; C Shaw; E Willey; Mary-Ann Ampong; L Wijesekera; T Rittman; P Nigel Leigh; Paul S Sidhu; Ammar Al-Chalabi
Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone disease.
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association 2010;23(4):408-15.
2010: Robin Lemmens; Melissa J Moore; Ammar Al-Chalabi; Robert H Brown; Wim Robberecht
RNA metabolism and the pathogenesis of motor neuron diseases.
Trends in neurosciences 2010;33(5):249-58.
2009: Ammar Al-Chalabi
Genome-wide association studies.
Cold Spring Harbor protocols 2009;2009(12):pdb.top66.
2009: Mario Sabatelli; Fabrizio Eusebi; Ammar Al-Chalabi; Amelia Conte; Francesca Madia; Marco Luigetti; Irene Mancuso; Cristina Limatola; Flavia Trettel; Fabrizia Sobrero; Silvia Di Angelantonio; Francesca Grassi; Maria Amalia Di Castro; Claudia Moriconi; Sergio Fucile; Serena Lattante; Giuseppe Marangi; Marina Murdolo; Daniela Orteschi; Alessandra Del Grande; Pietro Tonali; Giovanni Neri; Marcella Zollino
Rare missense variants of neuronal nicotinic acetylcholine receptor altering receptor function are associated with sporadic amyotrophic lateral sclerosis.
Human molecular genetics 2009;18(20):3997-4006.
2009: A-M Wills; Simon Cronin; A Slowik; D Kasperaviciute; M A Van Es; J M Morahan; P N Valdmanis; V Meininger; J Melki; Christopher Shaw; G A Rouleau; E M C Fisher; P J Shaw; K E Morrison; R Pamphlett; L H Van den Berg; Denise A Figlewicz; Peter M Andersen; Ammar Al-Chalabi; O Hardiman; Shaun Purcell; J E Landers; Robert H Brown
A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS.
Neurology 2009;73(1):16-24.
2009: Amy W Butler; Mandy Y M Ng; Marian Hamshere; Paola Forabosco; Richard Wroe; Ammar Al-Chalabi; Cathryn M Lewis; John F Powell
Meta-analysis of linkage studies for Alzheimer's disease--a web resource.
Neurobiology of aging 2009;30(7):1037-47.
2009: Dylan Lewis; Mary-Ann Ampong; Alan Rio; Emma Willey; Julia Johnson; Christopher Shaw; CM Ellis; Ammar Al-Chalabi; P Nigel Leigh; Paul S Sidhu
Mushroom-cage gastrostomy tube placement in patients with amyotrophic lateral sclerosis: a 5-year experience in 104 patients in a single institution.
European radiology 2009;19(7):1763-71.
2009: Neeti Hindocha; Rima Nabbout; Frances Elmslie; Andrew Makoff; Ammar Al-Chalabi; Lina Nashef
A case report of a family with overlapping features of autosomal dominant febrile seizures and GEFS+.
Epilepsia 2009;50(4):937-42.
2009: L C Wijesekera; S Mathers; P Talman; C Galtrey; M H Parkinson; J Ganesalingam; E Willey; M A Ampong; C M Ellis; Christopher Shaw; Ammar Al-Chalabi; P Nigel Leigh
Natural history and clinical features of the flail arm and flail leg ALS variants.
Neurology 2009;72(12):1087-94.
2009: Caroline Vance; Boris Rogelj; Tibor Hortobágyi; Kurt J De Vos; Agnes Lumi Nishimura; Jemeen Sreedharan; Xun Hu; Bradley Smith; Deborah Ruddy; Paul Wright; Jeban Ganesalingam; Kelly L Williams; Vineeta Tripathi; Safa Al-Saraj; Ammar Al-Chalabi; P Nigel Leigh; Ian P Blair; Garth Nicholson; Jackie de Belleroche; Jean-Marc Gallo; Christopher C J Miller; Christopher Shaw
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
Science (New York, N.Y.) 2009;323(5918):1208-11.
2009: Paul Wicks; Sharon Abrahams; B Papps; Ammar Al-Chalabi; Christopher Shaw; P Nigel Leigh; Laura H Goldstein
SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis.
Journal of neurology 2009;256(2):234-41.
2009: Ana Beleza-Meireles; Ammar Al-Chalabi
Genetic studies of amyotrophic lateral sclerosis: controversies and perspectives.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2009;10(1):1-14.
2009: Claire L Simpson; Robin Lemmens; Katarzyna Miskiewicz; Wendy J Broom; Valerie K Hansen; Paul W J van Vught; John E Landers; Peter Sapp; Ludo Van Den Bosch; Joanne Knight; Benjamin M Neale; Martin R Turner; Jan Veldink; Roel A Ophoff; Vineeta B Tripathi; Ana Beleza; Meera N Shah; Petroula Proitsi; Annelies Van Hoecke; Peter Carmeliet; H Robert Horvitz; P Nigel Leigh; Christopher Shaw; Leonard H van den Berg; Pak C Sham; John F Powell; Patrik Verstreken; Robert H Brown; Wim Robberecht; Ammar Al-Chalabi
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
Human molecular genetics 2009;18(3):472-81.
2009: Frank P Diekstra; Ana Beleza-Meireles; Nigel P Leigh; Christopher Shaw; Ammar Al-Chalabi
Interaction between PON1 and population density in amyotrophic lateral sclerosis.
Neuroreport 2009;20(2):186-90.
2009: Louise V Wain; Inti Pedroso; John E Landers; Gerome Breen; Christopher E Shaw; P Nigel Leigh; Robert H Brown; Martin D Tobin; Ammar Al-Chalabi
The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.
PloS one 2009;4(12):e8175.
2009: Ammar Al-Chalabi; Alexandra Dürr; Nicholas W Wood; Michael H Parkinson; Agnes Camuzat; Jean-Sébastien Hulot; Karen E Morrison; Adrian Renton; Sigurd D Sussmuth; Bernhard G Landwehrmeyer; Albert Ludolph; Yves Agid; Alexis Brice; P Nigel Leigh; Gilbert Bensimon
Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.
PloS one 2009;4(9):e7114.
2009: Jeban Ganesalingam; Daniel Stahl; Lokesh Wijesekera; Clare Galtrey; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Latent cluster analysis of ALS phenotypes identifies prognostically differing groups.
PloS one 2009;4(9):e7107.
2009: Kirsten M Scott; Kumar Abhinav; Biba R Stanton; Clare Johnston; Martin R Turner; Mary-Ann Ampong; Mohamed Sakel; Richard W Orrell; Robin Howard; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Geographical clustering of amyotrophic lateral sclerosis in South-East England: a population study.
Neuroepidemiology 2009;32(2):81-8.
2008: John E Landers; Lijia Shi; Ting-Jan Cho; Jonathan D Glass; Christopher Shaw; P Nigel Leigh; Frank Diekstra; Meraida Polak; Ildefonso Rodriguez-Leyva; Stephan Niemann; Bryan Joseph Traynor; Diane McKenna-Yasek; Peter C Sapp; Ammar Al-Chalabi; Anne-Marie A Wills; Robert H Brown
A common haplotype within the PON1 promoter region is associated with sporadic ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2008;9(5):306-14.
2008: Richard Wroe; Amy Wai-Ling Butler; Peter M Andersen; John F Powell; Ammar Al-Chalabi
ALSOD: the Amyotrophic Lateral Sclerosis Online Database.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2008;9(4):249-50.
2008: Elsmarieke van de Giessen; Isabella Fogh; Sumana Gopinath; Bradley Smith; Xun Hu; John Powell; Peter Andersen; Garth Nicholson; Ammar Al-Chalabi; Christopher Shaw
Association study on glutathione S-transferase omega 1 and 2 and familial ALS.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2008;9(2):81-4.
2008: Jemeen Sreedharan; Ian P Blair; Vineeta B Tripathi; Xun Hu; Caroline Vance; Boris Rogelj; Steven Ackerley; Jennifer C Durnall; Kelly L Williams; Emanuele Buratti; Francisco Baralle; Jackie de Belleroche; Douglas Mitchell; P Nigel Leigh; Ammar Al-Chalabi; Christopher C J Miller; Garth Nicholson; Christopher Shaw
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
Science (New York, N.Y.) 2008;319(5870):1668-72.
2008: Vineeta B Tripathi; Ammar Al-Chalabi
Molecular insights and therapeutic targets in amyotrophic lateral sclerosis.
CNS & neurological disorders drug targets 2008;7(1):11-9.
2008: Neeti Hindocha; Lina Nashef; Frances Elmslie; Rachael Birch; Sameer Zuberi; Ammar Al-Chalabi; Lia Crotti; Peter J Schwartz; Andrew Makoff
Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation.
Epilepsia 2008;49(2):360-5.
2008: A L McCormick; Robert H Brown; Merit E Cudkowicz; Ammar Al-Chalabi; Jeremy A Garson
Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate.
Neurology 2008;70(4):278-83.
2008: Umesh Vivekananda; Clare Johnston; Diane McKenna-Yasek; Christopher Shaw; P Nigel Leigh; Robert H Brown; Ammar Al-Chalabi
Birth order and the genetics of amyotrophic lateral sclerosis.
Journal of neurology 2008;255(1):99-102.
2007: Martin R Turner; Alexander Hammers; Joanna Allsop; Ammar Al-Chalabi; Christopher Shaw; David J Brooks; P Nigel Leigh; Peter M Andersen
Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2007;8(6):343-7.
2007: Dalia Kasperaviciute; Mike E Weale; Kevin V Shianna; Gareth T Banks; Claire L Simpson; Valerie K Hansen; Martin R Turner; Christopher Shaw; Ammar Al-Chalabi; Hardev S Pall; Emily F Goodall; Karen E Morrison; Richard W Orrell; Marcus Beck; Sibylle Jablonka; Michael Sendtner; Alice Brockington; Paul Geoffrey Ince; Judith Hartley; Hannah Nixon; Pamela J Shaw; Giampietro Schiavo; Nicholas W Wood; David B Goldstein; Elizabeth M C Fisher
Large-scale pathways-based association study in amyotrophic lateral sclerosis.
Brain : a journal of neurology 2007;130(Pt 9):2292-301.
2007: Ammar Al-Chalabi
The multidisciplinary clinic, quality of life and survival in motor neuron disease.
Journal of neurology 2007;254(8):1118.
2007: Isabella Fogh; Frühling Rijsdijk; Peter M Andersen; Pak C Sham; Joanne Knight; Benjamin Neale; Diane McKenna-Yasek; Vincenzo Silani; Robert H Brown; John F Powell; Ammar Al-Chalabi
Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality.
Neurogenetics 2007;8(3):235-6.
2007: Martin R Turner; Alexander Hammers; Ammar Al-Chalabi; Christopher Shaw; Peter M Andersen; David J Brooks; P Nigel Leigh
Cortical involvement in four cases of primary lateral sclerosis using [(11)C]-flumazenil PET.
Journal of neurology 2007;254(8):1033-6.
2007: Jeremy D Isaacs; Andrew F Dean; Christopher Shaw; Ammar Al-Chalabi; Kerry R Mills; P Nigel Leigh
Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):750-3.
2007: Paul Wicks; Jeban Ganesalingham; Christine Collin; Martin Prevett; Nigel P Leigh; Ammar Al-Chalabi
Three soccer playing friends with simultaneous amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2007;8(3):177-9.
2007: Kumar Abhinav; Ammar Al-Chalabi; Tibor Hortobagyi; P Nigel Leigh
Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature.
Journal of neurology, neurosurgery, and psychiatry 2007;78(5):450-3.
2007: Martin R Turner; Eugenii A Rabiner; Ammar Al-Chalabi; Christopher Shaw; David J Brooks; P Nigel Leigh; Peter M Andersen
Cortical 5-HT1A receptor binding in patients with homozygous D90A SOD1 vs sporadic ALS.
Neurology 2007;68(15):1233-5.
2007: Christopher Shaw; Virginia Arechavala-Gomeza; Ammar Al-Chalabi
Chapter 14 Familial amyotrophic lateral sclerosis.
Handbook of clinical neurology 2007;82():279-300.
2007: Ettore Beghi; Tiziana Mennini; Caterina Bendotti; Paolo Bigini; Giancarlo Logroscino; Adriano Chio; Orla Hardiman; Douglas Mitchell; Robert Swingler; Bryan Joseph Traynor; Ammar Al-Chalabi
The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure.
Current medicinal chemistry 2007;14(30):3185-200.
2007: K Abhinav; B Stanton; C Johnston; J Hardstaff; Richard W Orrell; R Howard; J Clarke; M Sakel; Mary-Ann Ampong; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry).
Neuroepidemiology 2007;29(1-2):44-8.
2006: Clare A Johnston; Biba R Stanton; Martin R Turner; Rebecca Gray; Ashley Hay-Ming Blunt; David Butt; Mary-Ann Ampong; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London.
Journal of neurology 2006;253(12):1642-3.
2006: Claire L Simpson; Ammar Al-Chalabi
Amyotrophic lateral sclerosis as a complex genetic disease.
Biochimica et biophysica acta 2006;1762(11-12):973-85.
2006: Christopher Shaw; Ammar Al-Chalabi
Susceptibility genes in sporadic ALS: separating the wheat from the chaff by international collaboration.
Neurology 2006;67(5):738-9.
2006: Caroline Vance; Ammar Al-Chalabi; Deborah Ruddy; Bradley N Smith; Xun Hu; Jemeen Sreedharan; Teepu Siddique; H Jurgen Schelhaas; Benno Kusters; Dirk Troost; Frank Baas; Vianney de Jong; Christopher Shaw
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3.
Brain : a journal of neurology 2006;129(Pt 4):868-76.
2006: M Morita; Ammar Al-Chalabi; Peter M Andersen; Betsy A Hosler; Peter C Sapp; E Englund; J E Mitchell; James Habgood; Jackie de Belleroche; J Xi; W Jongjaroenprasert; H Robert Horvitz; L-G Gunnarsson; Robert H Brown
A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia.
Neurology 2006;66(6):839-44.
2006: Ashley S Shaw; Mary-Ann Ampong; Alan Rio; Ammar Al-Chalabi; Maria E K Sellars; Catherine Ellis; Christopher Shaw; Nigel P Leigh; Paul S Sidhu
Survival of patients with ALS following institution of enteral feeding is related to pre-procedure oximetry: a retrospective review of 98 patients in a single centre.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2006;7(1):16-21.
2005: Agnes L Nishimura; Ammar Al-Chalabi; Mayana Zatz
A common founder for amyotrophic lateral sclerosis type 8 (ALS8) in the Brazilian population.
Human genetics 2005;118(3-4):499-500.
2005: Alan Rio; Mary-Ann Ampong; Martin R Turner; Ashley S Shaw; Ammar Al-Chalabi; Christopher Shaw; P Nigel Leigh; Paul S Sidhu
Comparison of two percutaneous radiological gastrostomy tubes in the nutritional management of ALS patients.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2005;6(3):177-81.
2005: Martin R Turner; Abena D Osei-Lah; Alexander Hammers; Ammar Al-Chalabi; Christopher Shaw; Peter M Andersen; David J Brooks; P Nigel Leigh; Kerry R Mills
Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.
Journal of neurology, neurosurgery, and psychiatry 2005;76(9):1279-85.
2005: Martin R Turner; Alexander Gerhard; Ammar Al-Chalabi; Christopher Shaw; Richard AC Hughes; Richard B Banati; David J Brooks; P Nigel Leigh
Mills' and other isolated upper motor neurone syndromes: in vivo study with 11C-(R)-PK11195 PET.
Journal of neurology, neurosurgery, and psychiatry 2005;76(6):871-4.
2005: Martin R Turner; Alexander Hammers; Ammar Al-Chalabi; Christopher Shaw; Peter M Andersen; David J Brooks; P Nigel Leigh
Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.
Brain : a journal of neurology 2005;128(Pt 6):1323-9.
2005: Martin R Turner; Eugenii A Rabiner; Alexander Hammers; Ammar Al-Chalabi; Paul M Grasby; Christopher Shaw; David J Brooks; P Nigel Leigh
[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.
Brain : a journal of neurology 2005;128(Pt 4):896-905.
2005: Ammar Al-Chalabi; P Nigel Leigh
Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?
Brain : a journal of neurology 2005;128(Pt 3):451-3.
2005: A J Steele; Ammar Al-Chalabi; Kimberly L Ferrante; Merit E Cudkowicz; Robert H Brown; Jeremy A Garson
Detection of serum reverse transcriptase activity in patients with ALS and unaffected blood relatives.
Neurology 2005;64(3):454-8.
2005: Emma Meaburn; Lee M Butcher; Lin Liu; Cathy Fernandes; Valerie K Hansen; Ammar Al-Chalabi; Robert Plomin; Ian W Craig; Leonard C Schalkwyk
Genotyping DNA pools on microarrays: tackling the QTL problem of large samples and large numbers of SNPs.
BMC genomics 2005;6():52.
2005: Claire L Simpson; Joanne Knight; Lee M Butcher; Valerie K Hansen; Emma Meaburn; Leonard C Schalkwyk; Ian W Craig; John F Powell; Pak C Sham; Ammar Al-Chalabi
A central resource for accurate allele frequency estimation from pooled DNA genotyped on DNA microarrays.
Nucleic acids research 2005;33(3):e25.
2004: Wendy Broom; Matthew J Parton; Caroline Vance; Carsten Russ; Peter M Andersen; Valerie K Hansen; P Nigel Leigh; John F Powell; Ammar Al-Chalabi; Christopher Shaw
No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALS.
Neurology 2004;63(12):2419-22.
2004: Claire L Simpson; Valerie K Hansen; Pak C Sham; ANDREW COLLINS; John F Powell; Ammar Al-Chalabi
MaGIC: a program to generate targeted marker sets for genome-wide association studies.
BioTechniques 2004;37(6):996-9.
2004: Lee M Butcher; Emma Meaburn; Lin Liu; Cathy Fernandes; Linzy Hill; Ammar Al-Chalabi; Robert Plomin; Leonard C Schalkwyk; Ian W Craig
Genotyping pooled DNA on microarrays: a systematic genome screen of thousands of SNPs in large samples to detect QTLs for complex traits.
Behavior genetics 2004;34(5):549-55.
2003: P Nigel Leigh; Sharon Abrahams; Ammar Al-Chalabi; Mary-Ann Ampong; Laura H Goldstein; J Johnson; RA Lyall; John Moxham; Naveed Mustfa; Alan Rio; C Shaw; E Willey
The management of motor neurone disease.
Journal of neurology, neurosurgery, and psychiatry 2003;74 Suppl 4():iv32-iv47.
2003: Deborah M Ruddy; Matthew J Parton; Ammar Al-Chalabi; Cathryn M Lewis; Caroline Vance; Bradley N Smith; P Nigel Leigh; John F Powell; Teepu Siddique; Eelco Postumus Meyjes; Frank Baas; Vianney de Jong; Christopher Shaw
Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q.
American journal of human genetics 2003;73(2):390-6.
2003: Ammar Al-Chalabi; Valerie K Hansen; Claire L Simpson; Jing Xi; Betsy A Hosler; John F Powell; Diane McKenna-Yasek; Christopher Shaw; P Nigel Leigh; Robert H Brown
Variants in the ALS2 gene are not associated with sporadic amyotrophic lateral sclerosis.
Neurogenetics 2003;4(4):221-2.
2003: Ammar Al-Chalabi; Margaret D Scheffler; Bradley N Smith; Matthew J Parton; Merit E Cudkowicz; Peter M Andersen; Douglas L Hayden; Valerie K Hansen; Martin R Turner; Christopher Shaw; P Nigel Leigh; Robert H Brown
Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis.
Annals of neurology 2003;54(1):130-4.
2003: Martin R Turner; Matthew J Parton; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Prolonged survival in motor neuron disease: a descriptive study of the King's database 1990-2002.
Journal of neurology, neurosurgery, and psychiatry 2003;74(7):995-7.
2003: Ammar Al-Chalabi; Christopher C J Miller
Neurofilaments and neurological disease.
BioEssays : news and reviews in molecular, cellular and developmental biology 2003;25(4):346-55.
2002: Martin Turner; Ammar Al-Chalabi
Early symptom progression rate is related to ALS outcome: a prospective population-based study.
Neurology 2002;59(12):2012-3; author reply 2013.
2002: Matthew J Parton; Wendy Broom; Peter M Andersen; Ammar Al-Chalabi; P Nigel Leigh; John F Powell; Christopher Shaw
D90A-SOD1 mediated amyotrophic lateral sclerosis: a single founder for all cases with evidence for a Cis-acting disease modifier in the recessive haplotype.
Human mutation 2002;20(6):473.
2002: Martin R Turner; M Bakker; P Sham; Christopher Shaw; P Nigel Leigh; Ammar Al-Chalabi
Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases 2002;3(1):15-21.
2001: Christopher Shaw; Ammar Al-Chalabi; Nigel P Leigh
Progress in the pathogenesis of amyotrophic lateral sclerosis.
Current neurology and neuroscience reports 2001;1(1):69-76.
2000: C M Lloyd; M P Richardson; David J Brooks; Ammar Al-Chalabi; P Nigel Leigh
Extramotor involvement in ALS: PET studies with the GABA(A) ligand [(11)C]flumazenil.
Brain : a journal of neurology 2000;123 ( Pt 11)():2289-96.
2000: William D Andrews; Philip W Tuke; Ammar Al-Chalabi; philippe gaudin; Samreen Ijaz; Matthew J Parton; Jeremy A Garson
Detection of reverse transcriptase activity in the serum of patients with motor neurone disease.
Journal of medical virology 2000;61(4):527-32.
1999: Ammar Al-Chalabi; Peter M Andersen; P Nilsson; BA Chioza; J L Andersson; Carsten Russ; Christopher Shaw; John F Powell; P Nigel Leigh
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.
Human molecular genetics 1999;8(2):157-64.
1998: Michele T M Hu; CM Ellis; Ammar Al-Chalabi; P Nigel Leigh; Christopher Shaw
Flail arm syndrome: a distinctive variant of amyotrophic lateral sclerosis.
Journal of neurology, neurosurgery, and psychiatry 1998;65(6):950-1.
1998: Ammar Al-Chalabi; Peter M Andersen; BA Chioza; C Shaw; P C Sham; Wim Robberecht; G Matthijs; William Camu; S L Marklund; Lars Forsgren; G Rouleau; N G Laing; P V Hurse; Teepu Siddique; P Nigel Leigh; John F Powell
Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor.
Human molecular genetics 1998;7(13):2045-50.
1998: Christopher Shaw; ZE Enayat; BA Chioza; Ammar Al-Chalabi; Aleksandar Radunovic; John F Powell; P Nigel Leigh
Mutations in all five exons of SOD-1 may cause ALS.
Annals of neurology 1998;43(3):390-4.
1997: William D Andrews; Ammar Al-Chalabi; Jeremy A Garson
Lack of evidence for HTLV tax-rex DNA in motor neurone disease.
Journal of the neurological sciences 1997;153(1):86-90.
1997: M Jackson; Ammar Al-Chalabi; ZE Enayat; BA Chioza; P Nigel Leigh; Karen E Morrison
Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation.
Annals of neurology 1997;42(5):803-7.
1997: Sharon Abrahams; Laura H Goldstein; Ammar Al-Chalabi; Alan D Pickering; Robin G Morris; R E Passingham; David J Brooks; P Nigel Leigh
Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis.
Journal of neurology, neurosurgery, and psychiatry 1997;62(5):464-72.
1996: F Hoda; D Nicholl; P Bennett; Maria J Arranz; KJ Aitchison; Ammar Al-Chalabi; Hiroshi Kunugi; Homero Vallada; P Nigel Leigh; K Ray Chaudhuri; D A Collier
No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase.
Biochemical and biophysical research communications 1996;228(3):780-4.
1996: M Jackson; Karen E Morrison; Ammar Al-Chalabi; M Bakker; P Nigel Leigh
Analysis of chromosome 5q13 genes in amyotrophic lateral sclerosis: homozygous NAIP deletion in a sporadic case.
Annals of neurology 1996;39(6):796-800.
1996: Ammar Al-Chalabi; ZE Enayat; M C Bakker; P C Sham; D M Ball; Christopher Shaw; C M Lloyd; John F Powell; P Nigel Leigh
Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease.
Lancet 1996;347(8995):159-60.
1995: Ammar Al-Chalabi; John F Powell; P Nigel Leigh
Neurofilaments, free radicals, excitotoxins, and amyotrophic lateral sclerosis.
Muscle & nerve 1995;18(5):540-5.