Lieping Chen

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Sun Yonglian; Brown Nicholas K; Ruddy Matthew J; Miller Mendy L; Lee Youjin; Wang Yang; Murphy Kenneth M; Pfeffer Klaus; Chen Lieping; Kaye Jonathan; Fu Yang-Xin
B and T lymphocyte attenuator tempers early infection immunity.
Yao Sheng; Wang Shengdian; Zhu Yuwen; Luo Liqun; Zhu Gefeng; Flies Sarah; Xu Haiying; Ruff William; Broadwater Megan; Choi In-Hak; Tamada Koji; Chen Lieping
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Gao X; Yu Q; Gu Q; Chen Y; Ding K; Zhu J; Chen L
Indoor air pollution from solid biomass fuels combustion in rural agricultural area of Tibet, China.

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2009: Sun Yonglian; Brown Nicholas K; Ruddy Matthew J; Miller Mendy L; Lee Youjin; Wang Yang; Murphy Kenneth M; Pfeffer Klaus; Chen Lieping; Kaye Jonathan; Fu Yang-Xin
B and T lymphocyte attenuator tempers early infection immunity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(3):1946-51.
2009: Yao Sheng; Wang Shengdian; Zhu Yuwen; Luo Liqun; Zhu Gefeng; Flies Sarah; Xu Haiying; Ruff William; Broadwater Megan; Choi In-Hak; Tamada Koji; Chen Lieping
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Blood 2009;113(23):5811-8.
2009: Gao X; Yu Q; Gu Q; Chen Y; Ding K; Zhu J; Chen L
Indoor air pollution from solid biomass fuels combustion in rural agricultural area of Tibet, China.
Indoor air 2009;19(3):198-205.
2009: Yi Kyung H; Chen Lieping
Fine tuning the immune response through B7-H3 and B7-H4.
Immunological reviews 2009;229(1):145-51.
2009: Phares Timothy W; Ramakrishna Chandran; Parra Gabriel I; Epstein Alan; Chen Lieping; Atkinson Roscoe; Stohlman Stephen A; Bergmann Cornelia C
Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(9):5430-8.
2009: Melero Ignacio; Martinez-Forero Ivan; Dubrot Juan; Suarez Natalia; Palazón Asis; Chen Lieping
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(5):1507-9.
2009: Zhu Yuwen; Chen Lieping
Turning the tide of lymphocyte costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(5):2557-8.
2009: Wang Xiaojie; Hao Jianqiang; Metzger Daniel L; Mui Alice; Ao Ziliang; Verchere C Bruce; Chen Lieping; Ou Dawei; Warnock Garth L
Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation 2009;87(4):482-90.
2009: Talay Oezcan; Shen Ching-Hung; Chen Lieping; Chen Jianzhu
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2741-6.
2009: Yamashita Taishi; Tamura Hideto; Satoh Chikako; Shinya Eiji; Takahashi Hidemi; Chen Lieping; Kondo Asaka; Tsuji Takashi; Dan Kazuo; Ogata Kiyoyuki
Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):770-7.
2009: Zhu Gefeng; Augustine Mathew M; Azuma Takeshi; Luo Liqun; Yao Sheng; Anand Sudarshan; Rietz A Cecilia; Huang Jiaqiang; Xu Haiying; Flies Andrew S; Flies Sarah J; Tamada Koji; Colonna Marco; van Deursen Jan M A; Chen Lieping
B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
Blood 2009;113(8):1759-67.
2008: Kryczek Ilona; Wei Shuang; Gong Wenrong; Shu Xiaogong; Szeliga Wojciech; Vatan Linhua; Chen Lieping; Wang Guobin; Zou Weiping
Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):5842-6.
2008: Schreiner Bettina; Bailey Samantha L; Shin Tahiro; Chen Lieping; Miller Stephen D
PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
European journal of immunology 2008;38(10):2706-17.
2008: Wahl Christian; Bochtler Petra; Chen Lieping; Schirmbeck Reinhold; Reimann Jörg
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology 2008;135(3):980-8.
2008: Lin Wei; Voskens Caroline J; Zhang Xiaoyu; Schindler Daniel G; Wood Aaron; Burch Erin; Wei Yadong; Chen Lieping; Tian Guoliang; Tamada Koji; Wang Lai-Xi; Schulze Dan H; Mann Dean; Strome Scott E
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies.
Blood 2008;112(3):699-707.
2008: Wei Shuang; Shreiner Andrew B; Takeshita Nobuhiro; Chen Lieping; Zou Weiping; Chang Alfred E
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Cancer research 2008;68(13):5432-8.
2008: Zou Weiping; Chen Lieping
Inhibitory B7-family molecules in the tumour microenvironment.
Nature reviews. Immunology 2008;8(6):467-77.
2008: Lafon Monique; Mégret Françoise; Meuth Sven G; Simon Ole; Velandia Romero Myriam L; Lafage Mireille; Chen Lieping; Alexopoulou Lena; Flavell Richard A; Prehaud Christophe; Wiendl Heinz
Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7506-15.
2008: Ortler Sonja; Leder Christoph; Mittelbronn Michel; Zozulya Alla L; Knolle Percy A; Chen Lieping; Kroner Antje; Wiendl Heinz
B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.
European journal of immunology 2008;38(6):1734-44.
2008: Azuma Takeshi; Yao Sheng; Zhu Gefeng; Flies Andrew S; Flies Sarah J; Chen Lieping
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Blood 2008;111(7):3635-43.
2008: Olofsson Peder S; Söderström Leif A; Wågsäter Dick; Sheikine Yuri; Ocaya Pauline; Lang François; Rabu Catherine; Chen Lieping; Rudling Mats; Aukrust Pål; Hedin Ulf; Paulsson-Berne Gabrielle; Sirsjö Allan; Hansson Göran K
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.
Circulation 2008;117(10):1292-301.
2008: Jeong Hye-Young; Lee Youn-Jae; Seo Su-Kil; Lee Soo-Woong; Park Sung-Jae; Lee Jeong-Nyeo; Sohn Hae-Sook; Yao Sheng; Chen Lieping; Choi Inhak
Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection.
Journal of leukocyte biology 2008;83(3):755-64.
2008: McNamara James O; Kolonias Despina; Pastor Fernando; Mittler Robert S; Chen Lieping; Giangrande Paloma H; Sullenger Bruce; Gilboa Eli
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
The Journal of clinical investigation 2008;118(1):376-86.
2008: Diehl Linda; Schurich Anna; Grochtmann Regina; Hegenbarth Silke; Chen Lieping; Knolle Percy A
Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.
Hepatology (Baltimore, Md.) 2008;47(1):296-305.
2008: Seo Su-Kil; Jeong Hye-Young; Park Sae-Gwang; Lee Soo-Woong; Choi Il-Whan; Chen Lieping; Choi Inhak
Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.
Immunology 2008;123(1):90-9.
2008: Hermes Gretchen; Ajioka James W; Kelly Krystyna A; Mui Ernest; Roberts Fiona; Kasza Kristen; Mayr Thomas; Kirisits Michael J; Wollmann Robert; Ferguson David J P; Roberts Craig W; Hwang Jong-Hee; Trendler Toria; Kennan Richard P; Suzuki Yasuhiro; Reardon Catherine; Hickey William F; Chen Lieping; McLeod Rima
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.
Journal of neuroinflammation 2008;5():48.
2007: Pentcheva-Hoang Tsvetelina; Chen Lieping; Pardoll Drew M; Allison James P
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17765-70.
2007: Kryczek Ilona; Wei Shuang; Zhu Gefeng; Myers Leann; Mottram Peter; Cheng Pui; Chen Lieping; Coukos George; Zou Weiping
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Cancer research 2007;67(18):8900-5.
2007: Mohamadzadeh Mansour; Chen Lieping; Schmaljohn Alan L
How Ebola and Marburg viruses battle the immune system.
Nature reviews. Immunology 2007;7(7):556-67.
2007: Goldberg Monica V; Maris Charles H; Hipkiss Edward L; Flies Andrew S; Zhen Lijie; Tuder Rubin M; Grosso Joseph F; Harris Timothy J; Getnet Derese; Whartenby Katharine A; Brockstedt Dirk G; Dubensky Thomas W; Chen Lieping; Pardoll Drew M; Drake Charles G
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Blood 2007;110(1):186-92.
2007: Tsushima Fumihiko; Yao Sheng; Shin Tahiro; Flies Andrew; Flies Sarah; Xu Haiying; Tamada Koji; Pardoll Drew M; Chen Lieping
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
Blood 2007;110(1):180-5.
2007: Zhu Yuwen; Zhu Gefeng; Luo Liqun; Flies Andrew S; Chen Lieping
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.
Blood 2007;109(11):4882-9.
2007: Chen Liangen; Zhang Zheng; Chen Weiwei; Zhang Zhidong; Li Yonggang; Shi Ming; Zhang Jiyuan; Chen Lieping; Wang Shengdian; Wang Fu-Sheng
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6634-41.
2007: Xu Yanhui; Flies Andrew S; Flies Dallas B; Zhu Gefeng; Anand Sudarshan; Flies Sarah J; Xu Haiying; Anders Robert A; Hancock Wayne W; Chen Lieping; Tamada Koji
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.
Blood 2007;109(9):4097-104.
2007: Flies Dallas B; Chen Lieping
The new B7s: playing a pivotal role in tumor immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(3):251-60.
2007: Niu Liguo; Strahotin Simona; Hewes Becker; Zhang Benyue; Zhang Yuanyuan; Archer David; Spencer Trent; Dillehay Dirck; Kwon Byoung; Chen Lieping; Vella Anthony T; Mittler Robert S
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4194-213.
2007: Melero Ignacio; Hervas-Stubbs Sandra; Glennie Martin; Pardoll Drew M; Chen Lieping
Immunostimulatory monoclonal antibodies for cancer therapy.
Nature reviews. Cancer 2007;7(2):95-106.
2007: Piconi Stefania; Trabattoni Daria; Saresella Marina; Iemoli Enrico; Schenal Monica; Fusi Alessandra; Borelli Manuela; Chen Lieping; Mascheri Ambra; Clerici Mario
Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1931-7.
2007: Xu Yanhui; Tamada Koji; Chen Lieping
LIGHT-related molecular network in the regulation of innate and adaptive immunity.
Immunologic research 2007;37(1):17-32.
2006: Zhang Xiaoyu; Dong Haidong; Lin Wei; Voss Stephen; Hinkley Lucinda; Westergren Melissa; Tian Guoliang; Berry Daniel; Lewellen David; Vile Richard G; Chen Lieping; Farber Donna L; Strome Scott E
Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6730-7.
2006: Chen L; Wang T; Zhou P; Ma L; Yin D; Shen J; Molinero L; Nozaki T; Phillips T; Uematsu S; Akira S; Wang C-R; Fairchild R L; Alegre M-L; Chong A
TLR engagement prevents transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(10):2282-91.
2006: Liu Xiaoyun; Martineau Tim; Chen Lieping; Zhan Shaokang; Tang Shenglan
Does decentralisation improve human resource management in the health sector? A case study from China.
Social science & medicine (1982) 2006;63(7):1836-45.
2006: Sun Yonglian; Blink Sarah E; Liu Wenhua; Lee Youjin; Chen Bohao; Solway Julian; Weinstock Joel; Chen Lieping; Fu Yang-Xin
Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):814-21.
2006: Salih Helmut Rainer; Wintterle Sabine; Krusch Matthias; Kroner Antje; Huang Yu-Hwa; Chen Lieping; Wiendl Heinz
The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.
Experimental hematology 2006;34(7):888-94.
2006: Kryczek Ilona; Wei Shuang; Zou Linhua; Zhu Gefeng; Mottram Peter; Xu Huanbin; Chen Lieping; Zou Weiping
Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):40-4.
2006: Yao Sheng; Chen Lieping
Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.
Trends in molecular medicine 2006;12(6):244-6.
2006: Kryczek Ilona; Zou Linhua; Rodriguez Paulo; Zhu Gefeng; Wei Shuang; Mottram Peter; Brumlik Michael; Cheng Pui; Curiel Tyler; Myers Leann; Lackner Andrew; Alvarez Xavier; Ochoa Augusto; Chen Lieping; Zou Weiping
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
The Journal of experimental medicine 2006;203(4):871-81.
2006: Anand Sudarshan; Wang Pu; Yoshimura Kiyoshi; Choi In-Hak; Hilliard Anja; Chen Youhai H; Wang Chyung-Ru; Schulick Richard; Flies Andrew S; Flies Dallas B; Zhu Gefeng; Xu Yanhui; Pardoll Drew M; Chen Lieping; Tamada Koji
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.
The Journal of clinical investigation 2006;116(4):1045-51.
2006: Tamada Koji; Chen Lieping
Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules.
Cancer immunology, immunotherapy : CII 2006;55(4):355-62.
2006: Tirapu Iñigo; Huarte Eduardo; Guiducci Cristiana; Arina Ainhoa; Zaratiegui Mikel; Murillo Oihana; Gonzalez Alvaro; Berasain Carmen; Berraondo Pedro; Fortes Puri; Prieto Jesús; Colombo Mario P; Chen Lieping; Melero Ignacio
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Cancer research 2006;66(4):2442-50.
2006: Lee Seung-Jin; Jang Byeong-Churl; Lee Soo-Woong; Yang Young-Il; Suh Seong-Il; Park Yeong-Min; Oh Sangtaek; Shin Jae-Gook; Yao Sheng; Chen Lieping; Choi In-Hak
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
FEBS letters 2006;580(3):755-62.
2006: Mohamadzadeh Mansour; Chen Lieping; Olinger Gene G; Pratt William D; Schmaljohn Alan L
Filoviruses and the balance of innate, adaptive, and inflammatory responses.
Viral immunology 2006;19(4):602-12.
2006: Ou Dawei; Wang Xiaojie; Metzger Daniel L; Ao Ziliang; Pozzilli Paolo; James Roger F L; Chen Lieping; Warnock Garth L
Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation 2006;15(5):399-410.
2006: Flies Dallas B; Chen Lieping
Modulation of immune response by B7 family molecules in tumor microenvironments.
Immunological investigations 2006;35(3-4):395-418.
2005: Jun Her; Seo Su K; Jeong Hye-Young; Seo Hyoun-Mi; Zhu Gefeng; Chen Lieping; Choi In-Hak
B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).
FEBS letters 2005;579(27):6259-64.
2005: de Haij Simone; Woltman Andrea M; Trouw Leendert A; Bakker Astrid C; Kamerling Sylvia W; van der Kooij Sandra W; Chen Lieping; Kroczek Richard A; Daha Mohamed R; van Kooten Cees
Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.
Kidney international 2005;68(5):2091-102.
2005: Thompson R Houston; Gillett Michael D; Cheville John C; Lohse Christine M; Dong Haidong; Webster W Scott; Chen Lieping; Zincke Horst; Blute Michael L; Leibovich Bradley C; Kwon Eugene D
Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma.
Cancer 2005;104(10):2084-91.
2005: Kim Jean; Myers Allen C; Chen Lieping; Pardoll Drew M; Truong-Tran Quynh-Ai; Lane Andrew P; McDyer John F; Fortuno Lowella; Schleimer Robert P
Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2005;33(3):280-9.
2005: Tamura Hideto; Dan Kazuo; Tamada Koji; Nakamura Kyoko; Shioi Yumiko; Hyodo Hideya; Wang Sheng-Dian; Dong Haidong; Chen Lieping; Ogata Kiyoyuki
Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5708-17.
2005: Vassallo Robert; Tamada Koji; Lau Julie S; Kroening Paula R; Chen Lieping
Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2684-91.
2005: Shin Tahiro; Yoshimura Kiyoshi; Shin Takako; Crafton Emily B; Tsuchiya Haruo; Housseau Franck; Koseki Haruhiko; Schulick Richard D; Chen Lieping; Pardoll Drew M
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2005;201(10):1531-41.
2005: Arribillaga Laura; Sarobe Pablo; Arina Ainhoa; Gorraiz Marta; Borrás-Cuesta Francisco; Ruiz Juan; Prieto Jesús; Chen Lieping; Melero Ignacio; Lasarte Juan José
Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.
Vaccine 2005;23(27):3493-9.
2005: Magnus Tim; Schreiner Bettina; Korn Thomas; Jack Carolyn; Guo Hong; Antel Jack; Ifergan Igal; Chen Lieping; Bischof Felix; Bar-Or Amit; Wiendl Heinz
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(10):2537-46.
2005: Hirano Fumiya; Kaneko Katsumi; Tamura Hideto; Dong Haidong; Wang Shengdian; Ichikawa Masao; Rietz Cecilia; Flies Dallas B; Lau Julie S; Zhu Gefeng; Tamada Koji; Chen Lieping
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Cancer research 2005;65(3):1089-96.
2005: Wang Liqing; Fraser Christopher C; Kikly Kristine; Wells Andrew D; Han Rongxiang; Coyle Anthony J; Chen Lieping; Hancock Wayne W
B7-H3 promotes acute and chronic allograft rejection.
European journal of immunology 2005;35(2):428-38.
2005: Shao Hui; Fu Yangxin; Liao Tianjiang; Peng Young; Chen Lieping; Kaplan Henry J; Sun Deming
Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells.
Investigative ophthalmology & visual science 2005;46(2):596-603.
2005: Melero Ignacio; Arina Ainhoa; Chen Lieping
The many sounds of T lymphocyte silence.
Immunologic research 2005;33(2):135-47.
2005: Ichikawa Masao; Chen Lieping
Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms.
Frontiers in bioscience : a journal and virtual library 2005;10():2856-60.
2004: Li Dongdong; Gál István; Vermes Csaba; Alegre Maria-Luisa; Chong Anita S F; Chen Lieping; Shao Qing; Adarichev Vyacheslava; Xu Xuemei; Koreny Tamas; Mikecz Katalin; Finnegan Alison; Glant Tibor T; Zhang Jian
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(12):7135-9.
2004: Thompson R Houston; Gillett Michael D; Cheville John C; Lohse Christine M; Dong Haidong; Webster W Scott; Krejci Kent G; Lobo John R; Sengupta Shomik; Chen Lieping; Zincke Horst; Blute Michael L; Strome Scott E; Leibovich Bradley C; Kwon Eugene D
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(49):17174-9.
2004: Luo Liqun; Chapoval Andrei I; Flies Dallas B; Zhu Gefeng; Hirano Fumiya; Wang Shengdian; Lau Julie S; Dong Haidong; Tamada Koji; Flies Andrew S; Liu Yang; Chen Lieping
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5445-50.
2004: Schreiner Bettina; Mitsdoerffer Meike; Kieseier Bernd C; Chen Lieping; Hartung Hans-Peter; Weller Michael; Wiendl Heinz
Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis.
Journal of neuroimmunology 2004;155(1-2):172-82.
2004: Curiel Tyler J; Coukos George; Zou Linhua; Alvarez Xavier; Cheng Pui; Mottram Peter; Evdemon-Hogan Melina; Conejo-Garcia Jose R; Zhang Lin; Burow Matthew; Zhu Yun; Wei Shuang; Kryczek Ilona; Daniel Ben; Gordon Alan; Myers Leann; Lackner Andrew; Disis Mary L; Knutson Keith L; Chen Lieping; Zou Weiping
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Nature medicine 2004;10(9):942-9.
2004: Radhakrishnan Suresh; Nguyen Loc Tan; Ciric Bogoljub; Flies Dallas; Van Keulen Virginia P; Tamada Koji; Chen Lieping; Rodriguez Moses; Pease Larry R
Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research 2004;64(14):4965-72.
2004: Wang Shengdian; Chen Lieping
Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.
Microbes and infection / Institut Pasteur 2004;6(8):759-66.
2004: Guo J H; Saiyin H; Wei Y H; Chen S; Chen L; Bi G; Ma L J; Zhou G J; Huang C Q; Yu L; Dai L
Expression of testis specific ankyrin repeat and SOCS box-containing 17 gene.
Archives of andrology 2004;50(3):155-61.
2004: Ward Irene M; Reina-San-Martin Bernardo; Olaru Alexandru; Minn Kay; Tamada Koji; Lau Julie S; Cascalho Marilia; Chen Lieping; Nussenzweig Andre; Livak Ferenc; Nussenzweig Michel C; Chen Junjie
53BP1 is required for class switch recombination.
The Journal of cell biology 2004;165(4):459-64.
2004: Vassallo Robert; Chen Lieping
Selective suppression of dendritic cell functions by cigarette smoke extract.
Chest 2004;125(5 Suppl):107S.
2004: Chen Lieping
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Nature reviews. Immunology 2004;4(5):336-47.
2004: Schreiber Karin; Cannon Ronald E; Karrison Theodore; Beck-Engeser Gabriele; Huo Dezheng; Tennant Raymond W; Jensen Heather; Kast W Martin; Krausz Thomas; Meredith Stephen C; Chen Lieping; Schreiber Hans
Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
Oncogene 2004;23(22):3972-9.
2004: Tirapu Iñigo; Arina Ainhoa; Mazzolini Guillermo; Duarte Marina; Alfaro Carlos; Feijoo Esperanza; Qian Cheng; Chen Lieping; Prieto Jesus; Melero Ignacio
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.
International journal of cancer. Journal international du cancer 2004;110(1):51-60.
2004: Zhang Xuewu; Schwartz Jean-Claude D; Guo Xiaoling; Bhatia Sumeena; Cao Erhu; Lorenz Michael; Cammer Michael; Chen Lieping; Zhang Zhong-Yin; Edidin Michael A; Nathenson Stanley G; Almo Steven C
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity 2004;20(3):337-47.
2004: Dong Haidong; Zhu Gefeng; Tamada Koji; Flies Dallas B; van Deursen Jan M A; Chen Lieping
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.
Immunity 2004;20(3):327-36.
2004: Subudhi Sumit K; Zhou Ping; Yerian Lisa M; Chin Robert K; Lo James C; Anders Robert A; Sun Yonglian; Chen Lieping; Wang Yang; Alegre Maria-Luisa; Fu Yang-Xin
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
The Journal of clinical investigation 2004;113(5):694-700.
2004: Wang Shengdian; Chen Lieping
T lymphocyte co-signaling pathways of the B7-CD28 family.
Cellular & molecular immunology 2004;1(1):37-42.
2004: Strome Scott E; Chen Lieping
Costimulation-based immunotherapy for head and neck cancer.
Current treatment options in oncology 2004;5(1):27-33.
2004: Rietz Cecilia; Chen Lieping
New B7 family members with positive and negative costimulatory function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):8-14.
2004: Wilcox Ryan A; Tamada Koji; Flies Dallas B; Zhu Gefeng; Chapoval Andrei I; Blazar Bruce R; Kast W Martin; Chen Lieping
Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.
Blood 2004;103(1):177-84.
2004: Mukherjee Pinku; Tinder Teresa L; Basu Gargi D; Pathangey Latha B; Chen Lieping; Gendler Sandra J
Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model.
Breast disease 2004;20():53-63.
2004: Anand Sudarshan; Chen Lieping
Control of autoimmune diseases by the B7-CD28 family molecules.
Current pharmaceutical design 2004;10(2):121-8.
2003: Lee Iris; Wang Liqing; Wells Andrew D; Ye Qunrui; Han Rongxiang; Dorf Martin E; Kuziel William A; Rollins Barrett J; Chen Lieping; Hancock Wayne W
Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(12):6929-35.
2003: Morris Gerald P; Chen Lieping; Kong Yi-chi M
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis.
Cellular immunology 2003;226(1):20-9.
2003: Tamura Hideto; Ogata Kiyoyuki; Dong Haidong; Chen Lieping
Immunology of B7-H1 and its roles in human diseases.
International journal of hematology 2003;78(4):321-8.
2003: Wintterle Sabine; Schreiner Bettina; Mitsdoerffer Meike; Schneider Dagmar; Chen Lieping; Meyermann Richard; Weller Michael; Wiendl Heinz
Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.
Cancer research 2003;63(21):7462-7.
2003: Choi In-Hak; Zhu Gefeng; Sica Gabriel L; Strome Scott E; Cheville John C; Lau Julie S; Zhu Yuwen; Flies Dallas B; Tamada Koji; Chen Lieping
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(9):4650-4.
2003: Strome Scott E; Dong Haidong; Tamura Hideto; Voss Stephen G; Flies Dallas B; Tamada Koji; Salomao Diva; Cheville John; Hirano Fumiya; Lin Wei; Kasperbauer Jan L; Ballman Karla V; Chen Lieping
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
Cancer research 2003;63(19):6501-5.
2003: Kanai Takanori; Totsuka Teruji; Uraushihara Koji; Makita Shin; Nakamura Tetsuya; Koganei Kazutaka; Fukushima Tsuneo; Akiba Hisaya; Yagita Hideo; Okumura Ko; Machida Utako; Iwai Hideyuki; Azuma Miyuki; Chen Lieping; Watanabe Mamoru
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(8):4156-63.
2003: Wiendl Heinz; Mitsdoerffer Meike; Schneider Dagmar; Chen Lieping; Lochmüller Hanns; Melms Arthur; Weller Michael
Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(13):1892-4.
2003: Rajagopalan Govindarajan; Kudva Yogish C; Chen Lieping; Wen Li; David Chella S
Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.
International immunology 2003;15(9):1035-44.
2003: Youngnak Pornpan; Kozono Yuko; Kozono Haruo; Iwai Hideyuki; Otsuki Noriko; Jin Hisayo; Omura Ken; Yagita Hideo; Pardoll Drew M; Chen Lieping; Azuma Miyuki
Differential binding properties of B7-H1 and B7-DC to programmed death-1.
Biochemical and biophysical research communications 2003;307(3):672-7.
2003: Shin Tahiro; Kennedy Gene; Gorski Kevin; Tsuchiya Haruo; Koseki Haruhiko; Azuma Miyuki; Yagita Hideo; Chen Lieping; Powell Jonathan; Pardoll Drew; Housseau Franck
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
The Journal of experimental medicine 2003;198(1):31-8.
2003: Zhu Yuwen; Chen Lieping
Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways.
Current opinion in investigational drugs (London, England : 2000) 2003;4(6):691-5.
2003: Sica Gabriel L; Choi In Hak; Zhu Gefeng; Tamada Koji; Wang Sheng Dian; Tamura Hideto; Chapoval Andrei I; Flies Dallas B; Bajorath Jürgen; Chen Lieping
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Immunity 2003;18(6):849-61.
2003: Flies Dallas B; Chen Lieping
A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.
Journal of immunological methods 2003;276(1-2):239-42.
2003: Dong Haidong; Chen Lieping
B7-H1 pathway and its role in the evasion of tumor immunity.
Journal of molecular medicine (Berlin, Germany) 2003;81(5):281-7.
2003: Wang Shengdian; Bajorath Jürgen; Flies Dallas B; Dong Haidong; Honjo Tasuku; Chen Lieping
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
The Journal of experimental medicine 2003;197(9):1083-91.
2003: Weinman Eric C; Roche Patrick C; Kasperbauer Jan L; Cha Steve S; Sargent Dan J; Cheville John; Murphy Linda M; Chen Lieping; Wettstein Peter J; Gostout Bobbie; Ferrone Soldano; Strome Scott E
Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma.
Cancer 2003;97(9):2203-11.
2003: Kurosawa Shin; Myers Allen C; Chen Lieping; Wang Shengdian; Ni Jian; Plitt James R; Heller Nicola M; Bochner Bruce S; Schleimer Robert P
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2003;28(5):563-73.
2003: Curiel Tyler J; Wei Shuang; Dong Haidong; Alvarez Xavier; Cheng Pui; Mottram Peter; Krzysiek Roman; Knutson Keith L; Daniel Ben; Zimmermann Maria Carla; David Odile; Burow Matthew; Gordon Alan; Dhurandhar Nina; Myers Leann; Berggren Ruth; Hemminki Akseli; Alvarez Ronald D; Emilie Dominique; Curiel David T; Chen Lieping; Zou Weiping
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Nature medicine 2003;9(5):562-7.
2003: Petroff Margaret G; Chen Lieping; Phillips Teresa A; Azzola Dagmar; Sedlmayr Peter; Hunt Joan S
B7 family molecules are favorably positioned at the human maternal-fetal interface.
Biology of reproduction 2003;68(5):1496-504.
2003: Trabattoni Daria; Saresella Marina; Biasin Mara; Boasso Adriano; Piacentini Luca; Ferrante Pasquale; Dong Haidong; Maserati Renato; Shearer Gene M; Chen Lieping; Clerici Mario
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.
Blood 2003;101(7):2514-20.
2003: Radhakrishnan Suresh; Nguyen Loc T; Ciric Bogoljub; Ure Daren R; Zhou Bin; Tamada Koji; Dong Haidong; Tseng Su-Yi; Shin Tahiro; Pardoll Drew M; Chen Lieping; Kyle Robert A; Rodriguez Moses; Pease Larry R
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1830-8.
2003: Dong Haidong; Strome Scott E; Matteson Eric L; Moder Kevin G; Flies Dallas B; Zhu Gefeng; Tamura Hideto; Driscoll Colin L W; Chen Lieping
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
The Journal of clinical investigation 2003;111(3):363-70.
2002: Li Xiaohong; Li Xiaodong; Huang Jianyong; Wei Lixin; Chen Lieping; Wu Mengchao; Guo Yajun
[Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo]
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2002;10(6):409-12.
2002: Sun Yonglian; Chen Helen M; Subudhi Sumit K; Chen Jonathan; Koka Rima; Chen Lieping; Fu Yang-Xin
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.
Nature medicine 2002;8(12):1405-13.
2002: Nguyen Loc T; Radhakrishnan Suresh; Ciric Bogoljub; Tamada Koji; Shin Tahiro; Pardoll Drew M; Chen Lieping; Rodriguez Moses; Pease Larry R
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.
The Journal of experimental medicine 2002;196(10):1393-8.
2002: Wilcox Ryan A; Tamada Koji; Strome Scott E; Chen Lieping
Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(8):4230-6.
2002: Wilcox Ryan A; Flies Dallas B; Wang Hao; Tamada Koji; Johnson Aaron J; Pease Larry R; Rodriguez Moses; Guo Yajun; Chen Lieping
Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.
Cancer research 2002;62(15):4413-8.
2002: Dong Haidong; Strome Scott E; Salomao Diva R; Tamura Hideto; Hirano Fumiya; Flies Dallas B; Roche Patrick C; Lu Jun; Zhu Gefeng; Tamada Koji; Lennon Vanda A; Celis Esteban; Chen Lieping
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Nature medicine 2002;8(8):793-800.
2002: Chapoval Andrei I; Zhu Gefeng; Chen Lieping
Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.
Molecular biotechnology 2002;21(3):259-64.
2002: May Kenneth F; Chen Lieping; Zheng Pan; Liu Yang
Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.
Cancer research 2002;62(12):3459-65.
2002: Hsu Tsui-Ling; Chang Yung-Chi; Chen Siu-Ju; Liu Yong-Jun; Chiu Allen W; Chio Chung-Ching; Chen Lieping; Hsieh Shie-Liang
Modulation of dendritic cell differentiation and maturation by decoy receptor 3.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4846-53.
2002: Tamada Koji; Ni Jian; Zhu Gefeng; Fiscella Michele; Teng Baiqin; van Deursen Jan M A; Chen Lieping
Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):4832-5.
2002: Wilcox Ryan A; Chapoval Andrei I; Gorski Kevin S; Otsuji Mizuto; Shin Tahiro; Flies Dallas B; Tamada Koji; Mittler Robert S; Tsuchiya Haruo; Pardoll Drew M; Chen Lieping
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4262-7.
2002: Petroff M G; Chen L; Phillips T A; Hunt J S
B7 family molecules: novel immunomodulators at the maternal-fetal interface.
Placenta 2002;23 Suppl A():S95-101.
2002: Wang Shengdian; Zhu Gefeng; Tamada Koji; Chen Lieping; Bajorath Jürgen
Ligand binding sites of inducible costimulator and high avidity mutants with improved function.
The Journal of experimental medicine 2002;195(8):1033-41.
2002: Chen Lieping
Antibody gene therapy: old wine in a new bottle.
Nature medicine 2002;8(4):333-4.
2002: Wilcox Ryan A; Chen Lieping
Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.
Frontiers in bioscience : a journal and virtual library 2002;7():d853-71.
2002: Strome Scott E; Voss Stephen; Wilcox Ryan; Wakefield Tamekia L; Tamada Koji; Flies Dallas; Chapoval Andrei; Lu Jun; Kasperbauer Jan L; Padley Douglas; Vile Richard; Gastineau Dennis; Wettstein Peter; Chen Lieping
Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.
Cancer research 2002;62(6):1884-9.
2002: Wilcox Ryan A; Flies Dallas B; Zhu Gefeng; Johnson Aaron J; Tamada Koji; Chapoval Andrei I; Strome Scott E; Pease Larry R; Chen Lieping
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.
The Journal of clinical investigation 2002;109(5):651-9.
2002: Strome Scott E; Martin Elizabeth; Flies Dallas; Khurana Dianne; Salomao Diva; Tamada Koji; Chapoval Andrei I; Kasperbauer Jan L; Olsen Kerry D; Chen Lieping
Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2002;126(2):180-7.
2002: Tamada Koji; Tamura Hideto; Flies Dallas; Fu Yang-Xin; Celis Esteban; Pease Larry R; Blazar Bruce R; Chen Lieping
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.
The Journal of clinical investigation 2002;109(4):549-57.
2002: Sun Yonglian; Lin Xiaoqi; Chen Helen M; Wu Qiang; Subudhi Sumit K; Chen Lieping; Fu Yang-Xin
Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1457-65.
2002: Strome Scott E; Kawakami Koji; Alejandro Danielle; Voss Stephen; Kasperbauer Jan L; Salomao Diva; Chen Lieping; Maki Richard A; Puri Raj K
Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):281-6.
2001: Wang J; Lo J C; Foster A; Yu P; Chen H M; Wang Y; Tamada K; Chen L; Fu Y X
The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT.
The Journal of clinical investigation 2001;108(12):1771-80.
2001: Wang J; Chun T; Lo J C; Wu Q; Wang Y; Foster A; Roca K; Chen M; Tamada K; Chen L; Wang C R; Fu Y X
The critical role of LIGHT, a TNF family member, in T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(9):5099-105.
2001: Khurana D; Martin E A; Kasperbauer J L; O'Malley B W; Salomao D R; Chen L; Strome S E
Characterization of a spontaneously arising murine squamous cell carcinoma (SCC VII) as a prerequisite for head and neck cancer immunotherapy.
Head & neck 2001;23(10):899-906.
2001: Zhu G; Flies D B; Tamada K; Sun Y; Rodriguez M; Fu Y X; Chen L
Progressive depletion of peripheral B lymphocytes in 4-1BB (CD137) ligand/I-Ealpha)-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2671-6.
2001: Chen L; Ong B; Bennett V
LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling.
The Journal of cell biology 2001;154(4):841-55.
2001: Pakala S V; Ilic A; Chen L; Sarvetnick N
TNF-alpha receptor 1 (p55) on islets is necessary for the expression of LIGHT on diabetogenic T cells.
Clinical immunology (Orlando, Fla.) 2001;100(2):198-207.
2001: Straight S W; Chen L; Karnak D; Margolis B
Interaction with mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.
Molecular biology of the cell 2001;12(5):1329-40.
2001: Sica G L; Zhu G; Tamada K; Liu D; Ni J; Chen L
RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB.
Blood 2001;97(9):2702-7.
2001: Melero I; Mazzolini G; Narvaiza I; Qian C; Chen L; Prieto J
IL-12 gene therapy for cancer: in synergy with other immunotherapies.
Trends in immunology 2001;22(3):113-5.
2001: Tamura H; Dong H; Zhu G; Sica G L; Flies D B; Tamada K; Chen L
B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function.
Blood 2001;97(6):1809-16.
2001: Chapoval A I; Ni J; Lau J S; Wilcox R A; Flies D B; Liu D; Dong H; Sica G L; Zhu G; Tamada K; Chen L
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
Nature immunology 2001;2(3):269-74.
2001: Bennett V; Chen L
Ankyrins and cellular targeting of diverse membrane proteins to physiological sites.
Current opinion in cell biology 2001;13(1):61-7.
2000: Chen L; Davis N G
Recycling of the yeast a-factor receptor.
The Journal of cell biology 2000;151(3):731-8.
2000: Wang S; Zhu G; Chapoval A I; Dong H; Tamada K; Ni J; Chen L
Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.
Blood 2000;96(8):2808-13.
2000: Tamada K; Chen L
T lymphocyte costimulatory molecules in host defense and immunologic diseases.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2000;85(3):164-75; quiz 175-7.
2000: Strome S E; Martin B; Flies D; Tamada K; Chapoval A I; Sargent D J; Shu S; Chen L
Enhanced therapeutic potential of adoptive immunotherapy by in vitro CD28/4-1BB costimulation of tumor-reactive T cells against a poorly immunogenic, major histocompatibility complex class I-negative A9P melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):430-7.
2000: Moorthy S; Chen L; Bennett V
Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function.
The Journal of cell biology 2000;149(4):915-30.
2000: Tamada K; Shimozaki K; Chapoval A I; Zhai Y; Su J; Chen S F; Hsieh S L; Nagata S; Ni J; Chen L
LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(8):4105-10.
2000: Chapoval A I; Tamada K; Chen L
In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells.
Blood 2000;95(7):2346-51.
2000: Tamada K; Shimozaki K; Chapoval A I; Zhu G; Sica G; Flies D; Boone T; Hsu H; Fu Y X; Nagata S; Ni J; Chen L
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway.
Nature medicine 2000;6(3):283-9.
2000: Sica G; Chen L
Modulation of the immune response through 4-1BB.
Advances in experimental medicine and biology 2000;465():355-62.
1999: Dong H; Zhu G; Tamada K; Chen L
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
Nature medicine 1999;5(12):1365-9.
1999: Hu S; Tamada K; Ni J; Vincenz C; Chen L
Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily.
Genomics 1999;62(1):103-7.
1999: Johnson A J; Njenga M K; Hansen M J; Kuhns S T; Chen L; Rodriguez M; Pease L R
Prevalent class I-restricted T-cell response to the Theiler's virus epitope Db:VP2121-130 in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28.
Journal of virology 1999;73(5):3702-8.
1999: Chen L
Mimotopes of cytolytic T lymphocytes in cancer immunotherapy.
Current opinion in immunology 1999;11(2):219-22.
1999: Chen L; Boomershine C; Wang T; Lafuse W P; Zwilling B S
Synergistic interaction of catecholamine hormones and Mycobacterium avium results in the induction of interleukin-10 mRNA expression by murine peritoneal macrophages.
Journal of neuroimmunology 1999;93(1-2):149-55.
1999: Hsieh J J; Zhou S; Chen L; Young D B; Hayward S D
CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):23-8.
1999: Sica G; Chen L
Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy.
Archivum immunologiae et therapiae experimentalis 1999;47(5):275-9.
1998: Semmes O J; Chen L; Sarisky R T; Gao Z; Zhong L; Hayward S D
Mta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA.
Journal of virology 1998;72(12):9526-34.
1998: Chen L
Immunological ignorance of silent antigens as an explanation of tumor evasion.
Immunology today 1998;19(1):27-30.
1998: Chen L
Overcoming T cell ignorance by providing costimulation. Implications for the immune response against cancer.
Advances in experimental medicine and biology 1998;451():159-65.
1997: Wick M; Dubey P; Koeppen H; Siegel C T; Fields P E; Chen L; Bluestone J A; Schreiber H
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
The Journal of experimental medicine 1997;186(2):229-38.
1997: Yang G; Hellström K E; Chen L
The role of B7-2 (CD86) in tumour immunity.
Expert opinion on investigational drugs 1997;6(6):677-84.
1997: Stine O C; McMahon F J; Chen L; Xu J; Meyers D A; MacKinnon D F; Simpson S; McInnis M G; Rice J P; Goate A; Reich T; Edenberg H J; Foroud T; Nurnberger J I; Detera-Wadleigh S D; Goldin L R; Guroff J; Gershon E S; Blehar M C; DePaulo J R
Initial genome screen for bipolar disorder in the NIMH genetics initiative pedigrees: chromosomes 2, 11, 13, 14, and X.
American journal of medical genetics 1997;74(3):263-9.
1997: Melero I; Singhal M C; McGowan P; Haugen H S; Blake J; Hellstrom K E; Yang G; Clegg C H; Chen L
Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.
Journal of virology 1997;71(5):3998-4004.
1997: Chen L
Manipulation of T cell response to tumors by targeting on costimulatory pathway.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1997;11 Suppl 3():567-9.
1996: Weih F; Ryseck R P; Chen L; Bravo R
Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5533-8.
1996: Hellström K E; Chen L; Hellström I
Costimulation of T-cell-mediated tumor immunity.
Cancer chemotherapy and pharmacology 1996;38 Suppl():S40-1.
1995: Hellström K E; Hellström I; Chen L
Can co-stimulated tumor immunity be therapeutically efficacious?
Immunological reviews 1995;145():123-45.
1994: Zhang L; Hellström K E; Chen L
Luciferase activity as a marker of tumor burden and as an indicator of tumor response to antineoplastic therapy in vivo.
Clinical & experimental metastasis 1994;12(2):87-92.
1993: Hellström K E; Hellström I; Linsley P; Chen L
On the role of costimulation in tumor immunity.
Annals of the New York Academy of Sciences 1993;690():225-30.

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