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Antonio Di Cristofano
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Research Profile (preview)
Living Beings
Chemicals & Drugs
Physiology
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Disorders
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Network (preview)
17
Pandolfi, Pier Paolo
9
La Mantia, Girolama
6
Cordon-Cardo, Carlos
4
Parisi, Tiziana
4
Strazzullo, Maria
3
Van Aelst, Linda
3
Zhao, Mingming
3
Lania, Luigi
3
Lian, Zenglin
3
Niki, Masaru
2
Hay, Nissim
2
Majello, Barbara
2
Pengue, G
2
Phukan, Sharbani
2
Clarkson, Bayard
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Geonetwork of Antonio Di Cristofano (preview)
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All Publications
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2009: Miller Kelly A; Yeager Nicole; Baker Kristen; Liao Xiao-Hui; Refetoff Samuel; Di Cristofano Antonio
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Cancer research 2009;69(8):3689-94.
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2009: Zeng Qinghua; Phukan Sharbani; Xu Yanfei; Sadim Maureen; Rosman Diana S; Pennison Michael; Liao Jie; Yang Guang-Yu; Huang Chiang-Ching; Valle Laura; Di Cristofano Antonio; de la Chapelle Albert; Pasche Boris
Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Cancer research 2009;69(2):678-86.
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2008: Tan Yinfei; Timakhov Roman A; Rao Mamta; Altomare Deborah A; Xu Jinfei; Liu Zemin; Gao Qingshen; Jhanwar Suresh C; Di Cristofano Antonio; Wiest David L; Knepper Janice E; Testa Joseph R
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.
Cancer research 2008;68(5):1296-302.
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2008: Yeager Nicole; Brewer Charlene; Cai Kathy Qi; Xu Xiang-Xi; Di Cristofano Antonio
Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.
Cancer research 2008;68(2):444-9.
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2007: Brewer Charlene; Yeager Nicole; Di Cristofano Antonio
Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT.
Cancer research 2007;67(17):8002-6.
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2007: Yeager Nicole; Klein-Szanto Andres; Kimura Shioko; Di Cristofano Antonio
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Cancer research 2007;67(3):959-66.
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2007: Di Cristofano Antonio; Ellenson Lora Hedrick
Endometrial carcinoma.
Annual review of pathology 2007;2():57-85.
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2006: Lian Zenglin; De Luca Pasquale; Di Cristofano Antonio
Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer.
Journal of cellular physiology 2006;208(2):255-66.
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2006: Chen Mei-Ling; Xu Pei-Zhang; Peng Xiao-ding; Chen William S; Guzman Grace; Yang Ximing; Di Cristofano Antonio; Pandolfi Pier Paolo; Hay Nissim
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Genes & development 2006;20(12):1569-74.
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2006: Vilgelm Anna; Lian Zenglin; Wang Hong; Beauparlant Stephen L; Klein-Szanto Andres; Ellenson Lora Hedrick; Di Cristofano Antonio
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Cancer research 2006;66(7):3375-80.
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2005: Lian Zenglin; Di Cristofano Antonio
Class reunion: PTEN joins the nuclear crew.
Oncogene 2005;24(50):7394-400.
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2005: Pasche Boris; Knobloch Thomas J; Bian Yansong; Liu Junjian; Phukan Sharbani; Rosman Diana; Kaklamani Virginia; Baddi Lisa; Siddiqui Farida S; Frankel Wendy; Prior Thomas W; Schuller David E; Agrawal Amit; Lang Jas; Dolan M Eileen; Vokes Everett E; Lane William S; Huang Chiang-Ching; Caldes Trinidad; Di Cristofano Antonio; Hampel Heather; Nilsson IngMarie; von Heijne Gunnar; Fodde Riccardo; Murty V V V S; de la Chapelle Albert; Weghorst Christopher M
Somatic acquisition and signaling of TGFBR1*6A in cancer.
JAMA : the journal of the American Medical Association 2005;294(13):1634-46.
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2005: Xiao Andrew; Yin Chaoying; Yang Chunyu; Di Cristofano Antonio; Pandolfi Pier Paolo; Van Dyke Terry
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.
Cancer research 2005;65(12):5172-80.
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2005: Wang Hui Qin; Altomare Deborah A; Skele Kristine L; Poulikakos Poulikos I; Kuhajda Francis P; Di Cristofano Antonio; Testa Joseph R
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Oncogene 2005;24(22):3574-82.
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2005: Bellacosa Alfonso; Kumar C Chandra; Di Cristofano Antonio; Testa Joseph Robert
Activation of AKT kinases in cancer: implications for therapeutic targeting.
Advances in cancer research 2005;94():29-86.
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2004: Niki Masaru; Di Cristofano Antonio; Zhao Mingming; Honda Hiroaki; Hirai Hisamaru; Van Aelst Linda; Cordon-Cardo Carlos; Pandolfi Pier Paolo
Role of Dok-1 and Dok-2 in leukemia suppression.
The Journal of experimental medicine 2004;200(12):1689-95.
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2004: Beauparlant Stephen L; Read Peter W; Di Cristofano Antonio
In vivo adenovirus-mediated gene transduction into mouse endometrial glands: a novel tool to model endometrial cancer in the mouse.
Gynecologic oncology 2004;94(3):713-8.
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2004: Ferri Anna L M; Cavallaro Maurizio; Braida Daniela; Di Cristofano Antonello; Canta Annalisa; Vezzani Annamaria; Ottolenghi Sergio; Pandolfi Pier Paolo; Sala Mariaelvina; DeBiasi Silvia; Nicolis Silvia K
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.
Development (Cambridge, England) 2004;131(15):3805-19.
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2003: Trotman Lloyd C; Niki Masaru; Dotan Zohar A; Koutcher Jason A; Di Cristofano Antonio; Xiao Andrew; Khoo Alan S; Roy-Burman Pradip; Greenberg Norman M; Van Dyke Terry; Cordon-Cardo Carlos; Pandolfi Pier Paolo
Pten dose dictates cancer progression in the prostate.
PLoS biology 2003;1(3):E59.
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2002: Kandel Eugene S; Skeen Jennifer; Majewski Nathan; Di Cristofano Antonio; Pandolfi Pier Paolo; Feliciano Claudine S; Gartel Andrei; Hay Nissim
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Molecular and cellular biology 2002;22(22):7831-41.
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2002: Lacorazza H Daniel; Miyazaki Yasushi; Di Cristofano Antonio; Deblasio Anthony; Hedvat Cyrus; Zhang Jin; Cordon-Cardo Carlos; Mao Shifeng; Pandolfi Pier Paolo; Nimer Stephen D
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells.
Immunity 2002;17(4):437-49.
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2002: Kim Sunghoon; Domon-Dell Claire; Wang Qingding; Chung Dai H; Di Cristofano Antonio; Pandolfi Pier Paolo; Freund Jean-Noel; Evers B Mark
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
Gastroenterology 2002;123(4):1163-78.
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2002: Li Li; Liu Fenghua; Salmonsen Rebecca A; Turner Tod K; Litofsky N Scott; Di Cristofano Antonio; Pandolfi Pier Paolo; Jones Stephen N; Recht Larry D; Ross Alonzo H
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Molecular and cellular neurosciences 2002;20(1):21-9.
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2002: Parisi Tiziana; Pollice Alessandra; Di Cristofano Antonio; Calabrò Viola; La Mantia Girolama
Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.
Biochemical and biophysical research communications 2002;291(5):1138-45.
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2001: Di Cristofano A; Niki M; Zhao M; Karnell F G; Clarkson B; Pear W S; Van Aelst L; Pandolfi P P
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
The Journal of experimental medicine 2001;194(3):275-84.
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2001: Zhao M; Schmitz A A; Qin Y; Di Cristofano A; Pandolfi P P; Van Aelst L
Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.
The Journal of experimental medicine 2001;194(3):265-74.
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2001: Di Cristofano A; De Acetis M; Koff A; Cordon-Cardo C; Pandolfi P P
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Nature genetics 2001;27(2):222-4.
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2001: Svensson A C; Raudsepp T; Larsson C; Di Cristofano A; Chowdhary B; La Mantia G; Rask L; Andersson G
Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9.
Cytogenetics and cell genetics 2001;92(1-2):89-96.
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2000: Arpaia E; Benveniste P; Di Cristofano A; Gu Y; Dalal I; Kelly S; Hershfield M; Pandolfi P P; Roifman C M; Cohen A
Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.
The Journal of experimental medicine 2000;191(12):2197-208.
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2000: Di Cristofano A; Pandolfi P P
The multiple roles of PTEN in tumor suppression.
Cell 2000;100(4):387-90.
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1999: Lee J O; Yang H; Georgescu M M; Di Cristofano A; Maehama T; Shi Y; Dixon J E; Pandolfi P; Pavletich N P
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Cell 1999;99(3):323-34.
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1999: Di Cristofano A; Kotsi P; Peng Y F; Cordon-Cardo C; Elkon K B; Pandolfi P P
Impaired Fas response and autoimmunity in Pten+/- mice.
Science (New York, N.Y.) 1999;285(5436):2122-5.
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1999: Calabrò V; Parisi T; Di Cristofano A; La Mantia G
Suppression of Ras-mediated NIH3T3 transformation by p19ARF does not involve alterations of cell growth properties.
Oncogene 1999;18(12):2157-62.
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1998: Di Cristofano A; Pesce B; Cordon-Cardo C; Pandolfi P P
Pten is essential for embryonic development and tumour suppression.
Nature genetics 1998;19(4):348-55.
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1998: Di Cristofano A; Carpino N; Dunant N; Friedland G; Kobayashi R; Strife A; Wisniewski D; Clarkson B; Pandolfi P P; Resh M D
Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.
The Journal of biological chemistry 1998;273(9):4827-30.
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1998: Strazzullo M; Parisi T; Di Cristofano A; Rocchi M; La Mantia G
Characterization and genomic mapping of chimeric ERV9 endogenous retroviruses-host gene transcripts.
Gene 1998;206(1):77-83.
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1995: Di Cristofano A; Strazzullo M; Parisi T; La Mantia G
Mobilization of an ERV9 human endogenous retroviral element during primate evolution.
Virology 1995;213(1):271-5.
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1995: Di Cristofano A; Strazzullo M; Longo L; La Mantia G
Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.
Nucleic acids research 1995;23(15):2823-30.
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1992: Lania L; Di Cristofano A; Strazzullo M; Pengue G; Majello B; La Mantia G
Structural and functional organization of the human endogenous retroviral ERV9 sequences.
Virology 1992;191(1):464-8.
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1992: La Mantia G; Majello B; Di Cristofano A; Strazzullo M; Minchiotti G; Lania L
Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: accurate transcription initiation is controlled by an Inr-like element.
Nucleic acids research 1992;20(16):4129-36.
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1991: La Mantia G; Maglione D; Pengue G; Di Cristofano A; Simeone A; Lanfrancone L; Lania L
Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.
Nucleic acids research 1991;19(7):1513-20.
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