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Antonio Di Cristofano

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Genes & Molecular Sequences

Genes, Tumor Suppressor

Disorders

Anatomy

Thyroid Gland

Co-author Network

Publications

TOP 3
Caterina Tiozzo; Radka Varimezova; Rehan Virender; David Warburton; Virender Rehan; Denise Al Alam; Sheryl Baptista; Saverio Bellusci; Soula Danopoulos; Stijn P De Langhe; Antonio Di Cristofano; Maria Lavarreda-Pearce; Parviz Minoo
Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.
Valeria G Antico Arciuch; Florence Dasrath; Mariavittoria Dima; Kristy S Kang; Xiao-Hui Liao; Cristina Montagna; Samuel Refetoff; Marika A Russo; Antonio Di Cristofano
Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.
Mariavittoria Dima; Kelly A Miller; Valeria Gabriela Antico-Arciuch; Antonio Di Cristofano
Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research.

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All Publications

2012: Caterina Tiozzo; Radka Varimezova; Rehan Virender; David Warburton; Virender Rehan; Denise Al Alam; Sheryl Baptista; Saverio Bellusci; Soula Danopoulos; Stijn P De Langhe; Antonio Di Cristofano; Maria Lavarreda-Pearce; Parviz Minoo
Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner.
Endocrine-related cancer 2012;19(2):111-22.
2011: Valeria G Antico Arciuch; Florence Dasrath; Mariavittoria Dima; Kristy S Kang; Xiao-Hui Liao; Cristina Montagna; Samuel Refetoff; Marika A Russo; Antonio Di Cristofano
Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.
Oncotarget 2011;2(12):1109-26.
2011: Mariavittoria Dima; Kelly A Miller; Valeria Gabriela Antico-Arciuch; Antonio Di Cristofano
Establishment and characterization of cell lines from a novel mouse model of poorly differentiated thyroid carcinoma: powerful tools for basic and preclinical research.
Thyroid : official journal of the American Thyroid Association 2011;21(9):1001-7.
2011: Sandra Herrero-Gonzalez; Antonio Di Cristofano
New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes.
Cancer discovery 2011;1(2):106-7.
2011: Marika A Russo; Valeria G Antico Arciuch; Antonio Di Cristofano
Mouse models of follicular and papillary thyroid cancer progression.
Frontiers in endocrinology 2011;2():119.
2010: V G Antico-Arciuch; M Dima; X-H Liao; S Refetoff; Antonio Di Cristofano
Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.
Oncogene 2010;29(42):5678-86.
2010: Deborah A Altomare; Lili Zhang; Jing Deng; Antonio Di Cristofano; Andres Klein-Szanto; Rakesh Kumar; Joseph R Testa
GSK690693 delays tumor onset and progression in genetically defined mouse models expressing activated Akt.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):486-96.
2009: Kelly A Miller; Nicole Yeager; Kristen Baker; Xiao-Hui Liao; Samuel Refetoff; Antonio Di Cristofano
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Cancer research 2009;69(8):3689-94.
2009: Qinghua Zeng; Sharbani Phukan; Yanfei Xu; Maureen Sadim; Diana S Rosman; Michael Pennison; Jie Liao; Guang-Yu Yang; Chiang-Ching Huang; Laura Valle; Antonio Di Cristofano; Albert de La Chapelle; Boris Pasche
Tgfbr1 haploinsufficiency is a potent modifier of colorectal cancer development.
Cancer research 2009;69(2):678-86.
2008: Yinfei Tan; Roman A Timakhov; Mamta Rao; Deborah A Altomare; Jinfei Xu; Zemin Liu; Qingshen Gao; Suresh C Jhanwar; Antonio Di Cristofano; David L. Wiest; Janice E Knepper; Joseph R Testa
A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.
Cancer research 2008;68(5):1296-302.
2008: Nicole Yeager; Charlene Brewer; Kathy Qi Cai; Xiangxi Xu; Antonio Di Cristofano
Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.
Cancer research 2008;68(2):444-9.
2007: Charlene Brewer; Nicole Yeager; Antonio Di Cristofano
Thyroid-stimulating hormone initiated proliferative signals converge in vivo on the mTOR kinase without activating AKT.
Cancer research 2007;67(17):8002-6.
2007: Nicole Yeager; Andres Klein-Szanto; Shioko Kimura; Antonio Di Cristofano
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Cancer research 2007;67(3):959-66.
2007: Antonio Di Cristofano; Lora Hedrick Ellenson
Endometrial carcinoma.
Annual review of pathology 2007;2():57-85.
2006: Zenglin Lian; Pasquale De Luca; Antonio Di Cristofano
Gene expression analysis reveals a signature of estrogen receptor activation upon loss of Pten in a mouse model of endometrial cancer.
Journal of cellular physiology 2006;208(2):255-66.
2006: Mei-Ling Chen; Pei-Zhang Xu; Xiao-ding Peng; William S Chen; Grace Guzman-Hartman; Ximing Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Nissim Hay
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Genes & development 2006;20(12):1569-74.
2006: Anna Vilgelm; Zenglin Lian; Hong Wang; Stephen L Beauparlant; Andres Klein-Szanto; Lora Hedrick Ellenson; Antonio Di Cristofano
Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice.
Cancer research 2006;66(7):3375-80.
2005: Zenglin Lian; Antonio Di Cristofano
Class reunion: PTEN joins the nuclear crew.
Oncogene 2005;24(50):7394-400.
2005: Boris Pasche; Thomas J Knobloch; Yansong Bian; Junjian Liu; Sharbani Phukan; Diana Rosman; Virginia G Kaklamani; Lisa Baddi; Farida S Siddiqui; Wendy Frankel; Thomas W Prior; David E Schuller; Amit Agrawal; Jas Lang; M Eileen Dolan; Everett E Vokes; William Stratton Lane; Chiang-Ching Huang; Trinidad Caldes; Antonio Di Cristofano; Heather Hampel; IngMarie Nilsson; Gunnar von Heijne; Riccardo Fodde; Vundavalli Murty; Albert de La Chapelle; Christopher M Weghorst
Somatic acquisition and signaling of TGFBR1*6A in cancer.
JAMA : the journal of the American Medical Association 2005;294(13):1634-46.
2005: Andrew Xiao; Chaoying Yin; Chunyu Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Terry Van Dyke
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.
Cancer research 2005;65(12):5172-80.
2005: Hui Qin Wang; Deborah A Altomare; Kristine L Skele; Poulikos I Poulikakos; Francis P Kuhajda; Antonio Di Cristofano; Joseph R Testa
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells.
Oncogene 2005;24(22):3574-82.
2005: Alfonso Bellacosa; C Chandra Kumar; Antonio Di Cristofano; Joseph Robert Testa
Activation of AKT kinases in cancer: implications for therapeutic targeting.
Advances in cancer research 2005;94():29-86.
2004: Masaru Niki; Antonio Di Cristofano; Mingming Zhao; Hiroaki Honda; Hisamaru Hirai; Linda Van Aelst; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Role of Dok-1 and Dok-2 in leukemia suppression.
The Journal of experimental medicine 2004;200(12):1689-95.
2004: Stephen L Beauparlant; Peter W Read; Antonio Di Cristofano
In vivo adenovirus-mediated gene transduction into mouse endometrial glands: a novel tool to model endometrial cancer in the mouse.
Gynecologic oncology 2004;94(3):713-8.
2004: Anna L M Ferri; Maurizio Cavallaro; Daniela Braida; Antonio Di Cristofano; Annalisa Canta; Annamaria Vezzani; Sergio Ottolenghi; Pier Paolo Pandolfi; Mariaelvina Sala; Silvia DeBiasi; Silvia K Nicolis
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.
Development (Cambridge, England) 2004;131(15):3805-19.
2003: Lloyd C Trotman; Masaru Niki; Zohar A Dotan; Jason A Koutcher; Antonio Di Cristofano; Andrew Xiao; Alan S Khoo; Pradip Roy-Burman; Norman M Greenberg; Terry Van Dyke; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten dose dictates cancer progression in the prostate.
PLoS biology 2003;1(3):E59.
2002: Eugene S Kandel; Jennifer E Skeen; Nathan Majewski; Antonio Di Cristofano; Pier Paolo Pandolfi; Claudine S Feliciano; Andrei L Gartel; Nissim Hay
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Molecular and cellular biology 2002;22(22):7831-41.
2002: H Daniel Lacorazza; Yasushi Miyazaki; Antonio Di Cristofano; Anthony Deblasio; Cyrus V Hedvat; Jin Zhang; Carlos Cordon-Cardo; Shifeng Mao; Pier Paolo Pandolfi; Stephen D Nimer
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells.
Immunity 2002;17(4):437-49.
2002: Sunghoon Kim; Claire Domon-Dell; Qingding Wang; Dai H Chung; Antonio Di Cristofano; Pier Paolo Pandolfi; Jean-Noel Freund; B Mark Evers
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
Gastroenterology 2002;123(4):1163-78.
2002: Li Li; Fenghua Liu; Rebecca A Salmonsen; Tod K Turner; N Scott Litofsky; Antonio Di Cristofano; Pier Paolo Pandolfi; Stephen N Jones; Lawrence D Recht; Alonzo H Ross
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Molecular and cellular neurosciences 2002;20(1):21-9.
2002: Tiziana Parisi; Alessandra Pollice; Antonio Di Cristofano; Viola Calabrò; Girolama La Mantia
Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors.
Biochemical and biophysical research communications 2002;291(5):1138-45.
2001: Antonio Di Cristofano; Masaru Niki; Mingming Zhao; Fredrick G Karnell; Bayard Clarkson; Warren S Pear; Linda Van Aelst; Pier Paolo Pandolfi
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
The Journal of experimental medicine 2001;194(3):275-84.
2001: Mingming Zhao; A A Schmitz; Y Qin; Antonio Di Cristofano; Pier Paolo Pandolfi; Linda Van Aelst
Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.
The Journal of experimental medicine 2001;194(3):265-74.
2001: Antonio Di Cristofano; M De Acetis; Andrew Koff; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Nature genetics 2001;27(2):222-4.
2001: AC Svensson; Terje Raudsepp; C Larsson; Antonio Di Cristofano; Bhanu P Chowdhary; Girolama La Mantia; Lars Rask; Göran Andersson
Chromosomal distribution, localization and expression of the human endogenous retrovirus ERV9.
Cytogenetics and cell genetics 2001;92(1-2):89-96.
2000: Enrico Arpaia; P Benveniste; Antonio Di Cristofano; Y Gu; Ilan Dalal; S Kelly; M Hershfield; P P Pandolfi; Chaim M Roifman; Amos Cohen
Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.
The Journal of experimental medicine 2000;191(12):2197-208.
2000: Antonio Di Cristofano; Pier Paolo Pandolfi
The multiple roles of PTEN in tumor suppression.
Cell 2000;100(4):387-90.
1999: JO Lee; Haijuan Yang; Maria-Magdalena Georgescu; Antonio Di Cristofano; T Maehama; Y Shi; J E Dixon; Pier Paolo Pandolfi; Nikola P Pavletich
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Cell 1999;99(3):323-34.
1999: Antonio Di Cristofano; P Kotsi; Y F Peng; Carlos Cordon-Cardo; K B Elkon; Pier Paolo Pandolfi
Impaired Fas response and autoimmunity in Pten+/- mice.
Science (New York, N.Y.) 1999;285(5436):2122-5.
1999: Viola Calabrò; Tiziana Parisi; Antonio Di Cristofano; Girolama La Mantia
Suppression of Ras-mediated NIH3T3 transformation by p19ARF does not involve alterations of cell growth properties.
Oncogene 1999;18(12):2157-62.
1998: Antonio Di Cristofano; B Pesce; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten is essential for embryonic development and tumour suppression.
Nature genetics 1998;19(4):348-55.
1998: Antonio Di Cristofano; N Carpino; N Dunant; G Friedland; Ryuji Kobayashi; Annabel Strife; David Wisniewski; Bayard Clarkson; Pier Paolo Pandolfi; Marilyn D Resh
Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.
The Journal of biological chemistry 1998;273(9):4827-30.
1998: Maria Strazzullo; Tiziana Parisi; Antonio Di Cristofano; Mariano Rocchi; Girolama La Mantia
Characterization and genomic mapping of chimeric ERV9 endogenous retroviruses-host gene transcripts.
Gene 1998;206(1):77-83.
1995: Antonio Di Cristofano; Maria Strazzullo; Tiziana Parisi; Girolama La Mantia
Mobilization of an ERV9 human endogenous retroviral element during primate evolution.
Virology 1995;213(1):271-5.
1995: Antonio Di Cristofano; M Strazzullo; L Longo; Girolama La Mantia
Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family.
Nucleic acids research 1995;23(15):2823-30.
1992: Luigi Lania; Antonio Di Cristofano; Maria Strazzullo; G Pengue; Barbara Majello; Girolama La Mantia
Structural and functional organization of the human endogenous retroviral ERV9 sequences.
Virology 1992;191(1):464-8.
1992: Girolama La Mantia; Barbara Majello; Antonio Di Cristofano; Maria Strazzullo; G Minchiotti; Luigi Lania
Identification of regulatory elements within the minimal promoter region of the human endogenous ERV9 proviruses: accurate transcription initiation is controlled by an Inr-like element.
Nucleic acids research 1992;20(16):4129-36.
1991: Girolama La Mantia; Domenico Maglione; G Pengue; Antonio Di Cristofano; A Simeone; Luisa Lanfrancone; Luigi Lania
Identification and characterization of novel human endogenous retroviral sequences prefentially expressed in undifferentiated embryonal carcinoma cells.
Nucleic acids research 1991;19(7):1513-20.